Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 24, 1999, Pages 14136-14141

  Járai, Zoltán ^a   Wagner, Jens A ^a,b   Varga, Károly ^a   Lake, Kristy D ^a   Compton, David R ^a   Martin, Billy R ^a   Zimmer, Anne M ^c   Bonner, Tom I ^c   Buckley, Nancy E ^c   Mezey, Eva ^c   Razdan, Raj K ^d   Zimmer, Andreas ^c   Kunos, George ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^d ORGANIX INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ANANDAMIDE; APAMIN; CANNABIDIOL; CANNABINOID; CANNABINOID RECEPTOR; CAPSAICIN; CHARYBDOTOXIN; DEXANABINOL; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; PROSTAGLANDIN SYNTHASE INHIBITOR; RIMONABANT; VANILLOID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; ENDOTHELIUM; HYPOTENSION; LIGAND BINDING; LOCOMOTION; MESENTERY BLOOD FLOW; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RECEPTOR BINDING; VASODILATATION;

ANIMALS; ARACHIDONIC ACIDS; CANNABIDIOL; CANNABINOIDS; ENDOTHELIUM, VASCULAR; MESENTERIC ARTERIES; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; MICE, KNOCKOUT; NITRIC OXIDE; PIPERIDINES; POLYUNSATURATED ALKAMIDES; POTASSIUM CHANNELS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; RECEPTOR, CANNABINOID, CB2; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; TETRAHYDROCANNABINOL; VASODILATION; VASODILATOR AGENTS;

ANIMALIA;

EID: 0038845604     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.24.14136     Document Type: Article

References (44)

1. Dewey, W. L. (1986) Pharmacol. Rev. 38, 151-178.
2. Devane, W. A., Hanus, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A. & Mechoulam, R. (1992) Science 258, 1946-1949.
3. Wagner, J. A., Varga, K. & Kunos, G. (1998) J. Mol. Med. 76, 824-836.
4. Vollmer, R. R., Cavero, I., Ertel, R. J., Solomon, T. A. & Buckley, J. P. (1974) J. Pharm. Pharmacol. 26, 186-192.
5. Varga, K., Lake, K., Martin, B. R. & Kunos, G. (1995) Eur. J. Pharmacol. 278, 279-283.
6. Varga, K., Lake, K. D., Huangfu, D., Guyenet, P. G. & Kunos, G. (1996) Hypertension 28, 682-686.
7. Ishac, E. J. N., Jiang, L., Lake, K. D., Varga, K., Abood, M. & Kunos, G. (1996) Br. J. Pharmacol. 118, 2023-2028.
8. Malinowska, B., Godlewski, G., Bucher, B. & Schlicker, E. (1997) Naunyn-Schmiedebergs Arch. Pharmacol. 356, 197-202.
9. Niederhoffer, N. & Szabo, B. (1999) Br. J. Pharmacol. 126, 457-466.
10. Lake, K. D., Compton, D. R., Varga, K., Martin, B. R. & Kunos, G. (1997) J. Pharmacol. Exp. Ther. 281, 1030-1037.
11. Vidrio, H., Sanchez-Salvatori, M. A. & Medina, M. (1996) J. Cardiovasc. Pharmacol. 28, 332-336.
12. Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C. & Bonner, T. I. (1990) Nature (London) 346, 561-564.
13. Shire, D., Carillon, C., Kaghad, M., Calandra, B., Rinaldi-Carmona, M., Le Fur, G. & Ferrara, P. (1995) J. Biol. Chem. 270, 3726-3731.
14. Munro, S., Thomas, K. L. & Abu-Shaar, M. (1993) Nature (London) 365, 61-65.
15. Ledent, C., Valverde, O., Cossu, G., Petitet, F., Aubert, J.-F., Beslot, F., Böhme, G. A., Imperato, A., Pedrazzini, T., Roques, B. P., et al. (1999) Science 283, 401-404.
16. Wagner, J. A., Varga, K., Járai, Z. & Kunos, G. (1999) Hypertension 33 (Part II), 429-434.
17. Howlett, A. C., Champion, T. M., Wilken, G. H. & Mechoulam, R. (1990) Neuropharmacology 29, 161-165.
18. Felder, C. C., Joyce, K. E., Briley, E. M., Mansouri, J., Mackie, K., Blond, O., Lai, Y., Ma, A. L. & Mitchell, R. L. (1995) Mol. Pharmacol. 48, 443-450.
19. Zimmer, A., Zimmer, A. M., Hohmann, A. G., Herkenham, M. & Bonner, T. I. (1999) Proc. Natl. Acad. Sci. USA 96, 5780-5785.
20. Lake, K. D., Martin, B. R., Kunos, G. & Varga, K. (1997) Hypertension 29, 1204-1210.
21. Smith, P. B., Compton, D. R., Welch, S. P., Razdan, R. K., Mechoulam, R. & Martin, B. R. (1994) J. Pharmacol. Exp. Ther. 270, 219-227.
22. Compton, D. R., Rice, K. C., de Costa, B. R., Razdan, R. K., Melvin, L. S., Johnson, M. R. & Martin, B. R. (1993) J. Pharmacol. Exp. Ther. 265, 218-226.
23. Razdan, R. K., Dalzell, H. C. & Handrick, G. R. (1974) J. Am. Chem. Soc. 96, 5860-5865.
24. Di Marzo, V., Fontana, A., Cadas, H., Schinelli, S., Cimino, G., Schwartz, J.-C. & Piomelli, D. (1994) Nature (London) 372, 686-691.
25. Abadji, V., Lin, S., Taha, G., Griffin, G., Stevenson, L. A., Pertwee, R. G. & Makriyannis, A. (1994) J. Med. Chem. 37, 1889-1893.
26. Rinaldi-Carmona, M., Earth, F., Heaulme, M., Shire, D., Calandra, B., Congy, C., Martinez, S., Maruani, J., Neliat, G., Caput, D., et al. (1994) FEBS Lett. 350, 240-244.
27. White, R. & Hiley, C. R. (1998) Br. J. Pharmacol. 125, 689-696.
28. Adams, M. D., Earnhardt, J. T., Martin, B. R., Harris, L. S., Dewey, W. L. & Razdan, R. K. (1977) Experientia 33, 1204-1205.
29. Mansbach, R. S., Rovetti, C. C., Winston, E. N. & Lowe, J. A. (1996) Psychopharmacology 124, 315-322.
30. Randall, M. D. & Kendall, D. A. (1998) Trends Pharmacol. Sci. 19, 55-58.
31. Di Marzo, V., Bisogno, T., Melck, D., Ross, R., Brockie, H., Stevenson, L., Pertwee, R. & De Petrocellis, L. (1998) FEBS Lett. 436, 449-454.
32. White, R. & Hiley, R. (1997) Br. J. Pharmacol. 122, 1573-1584.
33. Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H., Sørgård, M., Di Marzo, V., Julius, D. & Högestätt, E. D. (1999) Nature (London) 400, 452-457.
34. Gebremedhin, D., Lange, A. R., Campbell, W. B., Hillard, C. J. & Harder, D. R. (1999) Am. J. Physiol. 276, H2085-H2093.
35. Mombouli, J.-V., Schaeffer, G., Holzmann, S., Kostner, G. M. & Graier, W. F. (1999) Br. J. Pharmacol. 126, 1593-1600.
36. Hampson, A. J., Grimaldi, M., Axelrod, J. & Wink, D. (1998) Proc. Natl. Acad. Sci. USA 95, 8268-8273.
37. McCulloch, A. I., Bottrill, F. E., Randall, D. M. & Hiley, C. R. (1997) Br. J. Pharmacol. 120, 1431-1438.
38. Zygmunt, P. M. & Högestätt, E. D. (1996) Br. J. Pharmacol. 117, 1600-1606.
39. Edwards, G., Dora, K. A., Gardener, M. J., Garland, C. J. & Weston, A. H. (1998) Nature (London) 396, 269-272.
40. Campbell, W. B., Gebremedhin, D., Pratt, P. F. & Harder, D. R. (1996) Circ. Res. 78, 415-423.
41. Newby, A. C. & Henderson, A. H. (1990) Annu. Rev. Physiol. 52, 661-674.
42. Fimiani, C., Mattocks, D., Cavani, F., Salzet, M., Deutsch, D. G., Pryor, S., Bilfinger, T. V. & Stefano, B. G. (1999) Cell. Signal. 11, 189-193.
43. Deutsch, D. G., Goligorsky, M. S., Schmid, P. C., Krebsbach, R. J., Schmid, H. H., Das, S. K., Dey, S. K., Arreza, G., Thorup, C., Stefano, G. & Moore, L. C. (1997) J. Clin. Invest. 100, 1538-1546.
44. Sugiura, T., Kodaka, T., Nakane, S., Kishimoto, S., Kondo, S. & Waku, K. (1998) Biochem. Biophys. Res. Commun. 243, 838-843.