-
1
-
-
44849141696
-
Enzymatic pathways that regulate endocannabinoid signaling in the nervous system
-
Ahn K, McKinney MK, and Cravatt BF (2008) Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. Chem Rev 108:1687-1707.
-
(2008)
Chem Rev
, vol.108
, pp. 1687-1707
-
-
Ahn, K.1
McKinney, M.K.2
Cravatt, B.F.3
-
2
-
-
37149013708
-
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol
-
Blankman JL, Simon GM, and Cravatt BF (2007) A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem Biol 14:1347-1356.
-
(2007)
Chem Biol
, vol.14
, pp. 1347-1356
-
-
Blankman, J.L.1
Simon, G.M.2
Cravatt, B.F.3
-
3
-
-
0035979244
-
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
-
Cravatt BF, Demarest K, Patricelli MP, Bracey MH, Giang DK, Martin BR, and Lichtman AH (2001) Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase. Proc Natl Acad Sci USA 98:9371-9376.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 9371-9376
-
-
Cravatt, B.F.1
Demarest, K.2
Patricelli, M.P.3
Bracey, M.H.4
Giang, D.K.5
Martin, B.R.6
Lichtman, A.H.7
-
4
-
-
0029904838
-
Molecular characterization of an enzyme that degrades neuromodulatory fattyacid amides
-
Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA, and Gilula NB (1996) Molecular characterization of an enzyme that degrades neuromodulatory fattyacid amides. Nature 384:83-87.
-
(1996)
Nature
, vol.384
, pp. 83-87
-
-
Cravatt, B.F.1
Giang, D.K.2
Mayfield, S.P.3
Boger, D.L.4
Lerner, R.A.5
Gilula, N.B.6
-
5
-
-
55849117700
-
CB(1) receptor antagonism: Biological basis for metabolic effects
-
Di Marzo V (2008) CB(1) receptor antagonism: biological basis for metabolic effects. Drug Discov Today 13:1026-1041.
-
(2008)
Drug Discov Today
, vol.13
, pp. 1026-1041
-
-
Di Marzo, V.1
-
6
-
-
61749097208
-
The endocannabinoid system in metabolic control: A preface
-
Di Marzo V (2009) The endocannabinoid system in metabolic control: a preface. Best Pract Res Clin Endocrinol Metab 23:vii-ix.
-
(2009)
Best Pract Res Clin Endocrinol Metab
, vol.23
-
-
Di Marzo, V.1
-
7
-
-
0035848818
-
Leptin-regulated endocannabinoids are involved in maintaining food intake
-
Di Marzo V, Goparaju SK, Wang L, Liu J, Bátkai S, Járai Z, Fezza F, Miura GI, Palmiter RD, Sugiura T, et al. (2001) Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 410:822-825.
-
(2001)
Nature
, vol.410
, pp. 822-825
-
-
Di Marzo, V.1
Goparaju, S.K.2
Wang, L.3
Liu, J.4
Bátkai, S.5
Járai, Z.6
Fezza, F.7
Miura, G.I.8
Palmiter, R.D.9
Sugiura, T.10
-
8
-
-
0036678094
-
Brain monoglyceride lipase participating in endocannabinoid inactivation
-
Dinh TP, Carpenter D, Leslie FM, Freund TF, Katona I, Sensi SL, Kathuria S, and Piomelli D (2002) Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc Natl Acad Sci USA 99:10819-10824.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 10819-10824
-
-
Dinh, T.P.1
Carpenter, D.2
Leslie, F.M.3
Freund, T.F.4
Katona, I.5
Sensi, S.L.6
Kathuria, S.7
Piomelli, D.8
-
9
-
-
0029118444
-
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors
-
Felder CC, Joyce KE, Briley EM, Mansouri J, Mackie K, Blond O, Lai Y, Ma AL, and Mitchell RL (1995) Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol Pharmacol 48:443-450.
-
(1995)
Mol Pharmacol
, vol.48
, pp. 443-450
-
-
Felder, C.C.1
Joyce, K.E.2
Briley, E.M.3
Mansouri, J.4
Mackie, K.5
Blond, O.6
Lai, Y.7
Ma, A.L.8
Mitchell, R.L.9
-
10
-
-
0034613209
-
2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-alpha production in murine macrophages, and in mice
-
Gallily R, Breuer A, and Mechoulam R (2000) 2-Arachidonylglycerol, an endogenous cannabinoid, inhibits tumor necrosis factor-alpha production in murine macrophages, and in mice. Eur J Pharmacol 406:R5-7.
-
(2000)
Eur J Pharmacol
, vol.406
-
-
Gallily, R.1
Breuer, A.2
Mechoulam, R.3
-
11
-
-
47749088572
-
A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner
-
Goncalves MB, Suetterlin P, Yip P, Molina-Holgado F, Walker DJ, Oudin MJ, Zentar MP, Pollard S, Yáñez-Muñoz RJ, Williams G, et al. (2008) A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner. Mol Cell Neurosci 38:526-536.
-
(2008)
Mol Cell Neurosci
, vol.38
, pp. 526-536
-
-
Goncalves, M.B.1
Suetterlin, P.2
Yip, P.3
Molina-Holgado, F.4
Walker, D.J.5
Oudin, M.J.6
Zentar, M.P.7
Pollard, S.8
Yáñez-Muñoz, R.J.9
Williams, G.10
-
12
-
-
21344444379
-
An endocannabinoid mechanism for stress-induced analgesia
-
Hohmann AG, Suplita RL, Bolton NM, Neely MH, Fegley D, Mangieri R, Krey JF, Walker JM, Holmes PV, Crystal JD, et al. (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature 435:1108-1112.
-
(2005)
Nature
, vol.435
, pp. 1108-1112
-
-
Hohmann, A.G.1
Suplita, R.L.2
Bolton, N.M.3
Neely, M.H.4
Fegley, D.5
Mangieri, R.6
Krey, J.F.7
Walker, J.M.8
Holmes, P.V.9
Crystal, J.D.10
-
13
-
-
0027103851
-
Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation
-
Kaminski NE, Abood ME, Kessler FK, Martin BR, and Schatz AR (1992) Identification of a functionally relevant cannabinoid receptor on mouse spleen cells that is involved in cannabinoid-mediated immune modulation. Mol Pharmacol 42:736-742.
-
(1992)
Mol Pharmacol
, vol.42
, pp. 736-742
-
-
Kaminski, N.E.1
Abood, M.E.2
Kessler, F.K.3
Martin, B.R.4
Schatz, A.R.5
-
14
-
-
0037234363
-
Modulation of anxiety through blockade of anandamide hydrolysis
-
Kathuria S, Gaetani S, Fegley D, Valiño F, Duranti A, Tontini A, Mor M, Tarzia G, La Rana G, Calignano A, et al. (2003) Modulation of anxiety through blockade of anandamide hydrolysis. Nat Med 9:76-81.
-
(2003)
Nat Med
, vol.9
, pp. 76-81
-
-
Kathuria, S.1
Gaetani, S.2
Fegley, D.3
Valiño, F.4
Duranti, A.5
Tontini, A.6
Mor, M.7
Tarzia, G.8
La Rana, G.9
Calignano, A.10
-
15
-
-
70349110145
-
Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain
-
Kinsey SG, Long JZ, O'Neal ST, Abdullah RA, Poklis JL, Boger DL, Cravatt BF, and Lichtman AH (2009) Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. J Pharmacol Exp Ther 330:902-910.
-
(2009)
J Pharmacol Exp Ther
, vol.330
, pp. 902-910
-
-
Kinsey, S.G.1
Long, J.Z.2
O'Neal, S.T.3
Abdullah, R.A.4
Poklis, J.L.5
Boger, D.L.6
Cravatt, B.F.7
Lichtman, A.H.8
-
16
-
-
33747373548
-
Cannabinoid-induced immune suppression and modulation of antigen-presenting cells
-
DOI 10.1007/s11481-005-9007-x
-
Klein TW and Cabral GA (2006) Cannabinoid-induced immune suppression and modulation of antigen-presenting cells. J Neuroimmune Pharmacol 1:50-64. (Pubitemid 44257500)
-
(2006)
Journal of Neuroimmune Pharmacology
, vol.1
, Issue.1
, pp. 50-64
-
-
Klein, T.W.1
Cabral, G.A.2
-
17
-
-
0034660138
-
Delta 9-tetrahydrocannabinol treatment suppresses immunity and early IFN-gamma, IL-12, and IL-12 receptor beta 2 responses to Legionella pneumophila infection
-
Klein TW, Newton CA, Nakachi N, and Friedman H (2000) Delta 9-tetrahydrocannabinol treatment suppresses immunity and early IFN-gamma, IL-12, and IL-12 receptor beta 2 responses to Legionella pneumophila infection. J Immunol 164:6461-6466.
-
(2000)
J Immunol
, vol.164
, pp. 6461-6466
-
-
Klein, T.W.1
Newton, C.A.2
Nakachi, N.3
Friedman, H.4
-
19
-
-
23444432920
-
The endocannabinoid system: Drug targets, lead compounds, and potential therapeutic applications
-
Lambert DM and Fowler CJ (2005) The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. J Med Chem 48:5059-5087.
-
(2005)
J Med Chem
, vol.48
, pp. 5059-5087
-
-
Lambert, D.M.1
Fowler, C.J.2
-
20
-
-
0029561788
-
Effects of putative cannabinoid receptor ligands, anandamide and 2-arachidonyl-glycerol, on immune function in B6C3F1 mouse splenocytes
-
Lee M, Yang KH, and Kaminski NE (1995) Effects of putative cannabinoid receptor ligands, anandamide and 2-arachidonyl-glycerol, on immune function in B6C3F1 mouse splenocytes. J Pharmacol Exp Ther 275:529-536.
-
(1995)
J Pharmacol Exp Ther
, vol.275
, pp. 529-536
-
-
Lee, M.1
Yang, K.H.2
Kaminski, N.E.3
-
21
-
-
4644354869
-
Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: Evidence for an unprecedented combination of potency and selectivity
-
Lichtman AH, Leung D, Shelton CC, Saghatelian A, Hardouin C, Boger DL, and Cravatt BF (2004) Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. J Pharmacol Exp Ther 311:441-448.
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 441-448
-
-
Lichtman, A.H.1
Leung, D.2
Shelton, C.C.3
Saghatelian, A.4
Hardouin, C.5
Boger, D.L.6
Cravatt, B.F.7
-
22
-
-
57749087828
-
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
-
Long JZ, Li W, Booker L, Burston JJ, Kinsey SG, Schlosburg JE, Pavón FJ, Serrano AM, Selley DE, Parsons LH, et al. (2009) Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol 5:37-44.
-
(2009)
Nat Chem Biol
, vol.5
, pp. 37-44
-
-
Long, J.Z.1
Li, W.2
Booker, L.3
Burston, J.J.4
Kinsey, S.G.5
Schlosburg, J.E.6
Pavón, F.J.7
Serrano, A.M.8
Selley, D.E.9
Parsons, L.H.10
-
23
-
-
0036682222
-
The endogenous cannabinoid system controls extinction of aversive memories
-
Marsicano G, Wotjak CT, Azad SC, Bisogno T, Rammes G, Cascio MG, Hermann H, Tang J, Hofmann C, Zieglgänsberger W, et al. (2002) The endogenous cannabinoid system controls extinction of aversive memories. Nature 418:530-534.
-
(2002)
Nature
, vol.418
, pp. 530-534
-
-
Marsicano, G.1
Wotjak, C.T.2
Azad, S.C.3
Bisogno, T.4
Rammes, G.5
Cascio, M.G.6
Hermann, H.7
Tang, J.8
Hofmann, C.9
Zieglgänsberger, W.10
-
24
-
-
0036019386
-
Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance
-
Sugiura T, Kobayashi Y, Oka S, and Waku K (2002) Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. Prostaglandins Leukot Essent Fatty Acids 66:173-192.
-
(2002)
Prostaglandins Leukot Essent Fatty Acids
, vol.66
, pp. 173-192
-
-
Sugiura, T.1
Kobayashi, Y.2
Oka, S.3
Waku, K.4
-
26
-
-
0036015096
-
Evaluation of CB1 receptor knockout mice in the Morris water maze
-
Varvel SA and Lichtman AH (2002) Evaluation of CB1 receptor knockout mice in the Morris water maze. J Pharmacol Exp Ther 301:915-924.
-
(2002)
J Pharmacol Exp Ther
, vol.301
, pp. 915-924
-
-
Varvel, S.A.1
Lichtman, A.H.2
-
27
-
-
51149090640
-
A fluorescence-based assay for monoacylglycerol lipase compatible with inhibitor screening
-
Wang Y, Chanda P, Jones PG, and Kennedy JD (2008) A fluorescence-based assay for monoacylglycerol lipase compatible with inhibitor screening. Assay Drug Dev Technol 6:387-393.
-
(2008)
Assay Drug Dev Technol
, vol.6
, pp. 387-393
-
-
Wang, Y.1
Chanda, P.2
Jones, P.G.3
Kennedy, J.D.4
-
28
-
-
28844447455
-
A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833
-
Whiteside GT, Gottshall SL, Boulet JM, Chaffer SM, Harrison JE, Pearson MS, Turchin PI, Mark L, Garrison AE, and Valenzano KJ (2005) A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833. Eur J Pharmacol 528:65-72.
-
(2005)
Eur J Pharmacol
, vol.528
, pp. 65-72
-
-
Whiteside, G.T.1
Gottshall, S.L.2
Boulet, J.M.3
Chaffer, S.M.4
Harrison, J.E.5
Pearson, M.S.6
Turchin, P.I.7
Mark, L.8
Garrison, A.E.9
Valenzano, K.J.10
-
29
-
-
76249109553
-
Simultaneous determination of 2-arachidonoylglycerol, 1-arachidonoylglycerol and arachidonic acid in mouse brain tissue using liquid chromatography/tandem mass spectrometry
-
Zhang MY, Gao Y, Btesh J, Kagan N, Kerns E, Samad TA, and Chanda PK (2010) Simultaneous determination of 2-arachidonoylglycerol, 1-arachidonoylglycerol and arachidonic acid in mouse brain tissue using liquid chromatography/tandem mass spectrometry. J Mass Spectrom 45:167-177.
-
(2010)
J Mass Spectrom
, vol.45
, pp. 167-177
-
-
Zhang, M.Y.1
Gao, Y.2
Btesh, J.3
Kagan, N.4
Kerns, E.5
Samad, T.A.6
Chanda, P.K.7
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