Behavioural assessment of drug reinforcement and addictive features in rodents: An overview

Addiction Biology

Volumn 11, Issue 1, 2006, Pages 2-38

  Sanchis Segura, Carles ^a,b   Spanagel, Rainer ^a  

^a Central Institute of Mental Health   (Germany)

^b CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

Addictive behaviour; Drug seeking; Drug taking; Loss of control; Methods; Reinforcement; Relapse

Indexed keywords

ADDICTION; COMPULSION; CONDITIONING; DAILY LIFE ACTIVITY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DRUG SELF ADMINISTRATION; ELECTROSTIMULATION; IMPULSIVENESS; INSTRUMENTAL CONDITIONING; LEARNING; MEMORY; MOTIVATION; NONHUMAN; PLACE PREFERENCE; PRIORITY JOURNAL; RAT; REINFORCEMENT; RELAPSE; REVIEW; SENSITIZATION; SOCIAL BEHAVIOR; STIMULUS RESPONSE; ALCOHOLISM; ANIMAL; ANIMAL BEHAVIOR; DISEASE MODEL; DRUG EFFECT; HUMOR; PSYCHOLOGICAL ASPECT; PSYCHOLOGICAL MODEL; REWARD; RODENT; SELF STIMULATION; WITHDRAWAL SYNDROME;

ALCOHOLISM; ANIMALS; ASSOCIATION LEARNING; BEHAVIOR, ANIMAL; CONDITIONING (PSYCHOLOGY); DISEASE MODELS, ANIMAL; MODELS, PSYCHOLOGICAL; MOTIVATION; REINFORCEMENT SCHEDULE; REWARD; RODENTIA; SELF STIMULATION; SUBSTANCE WITHDRAWAL SYNDROME; SUBSTANCE-RELATED DISORDERS; WIT AND HUMOR;

EID: 33750686609     PISSN: 13556215     EISSN: 13691600     Source Type: Journal    
DOI: 10.1111/j.1369-1600.2006.00012.x     Document Type: Review

References (199)

1. Ackroff K, Rozental D, Sclafani A (2004) Ethanol-conditioned place preferences compared with sugar- and fat-conditioned preferences in rats. Physiol Behav 81 : 699 713.
2. Ahmed SH (2005) Imbalance between drug and non-drug reward availability: a major risk factor for addiction. Eur J Pharmacol 526 : 9 20.
3. Ahmed SH, Kenny PJ, Koob GF, Markou A (2002) Neurobiological evidence for hedonic allostasis associated with escalating cocaine use. Nat Neurosci 5 : 625 628.
4. Ahmed SH, Koob GF (2005) Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function. Psychopharmacology 180 : 473 490.
5. Bachteler D, Economidou D, Daynsz W, Ciccocioppo R, Spanagel R (2005) The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behaviour in rat. Neuropsychopharmacology 30 : 1104 1110.
6. Badiani A, Oates MM, Robinson TE (2000) Modulation of morphine sensitization in the rat by contextual stimuli. Psychopharmacology 151 : 273 282.
7. Baldwin HA, Wall TL, Schuckit MA, Koob GF (1991) Differential effects of ethanol on punished responding in the P and NO rats. Alcohol Clin Exp Res 15 : 700 704.
8. Bardo MT, Bevins RA (2000) Conditioned place preference: what does it add to our understanding of preclinical reward. Psychopharmacology 153 : 31 43.
9. Bardo MT, Rowlett JK, Harris MJ (1995) Conditioned place preference using opiate an stimulant drugs: a meta-analysis. Neurosci Biobehav Rev 19 : 39 51.
10. Bechara A (2003) Risky business: emotion, decision-making and addiction. J Gambl Stud 19 : 23 51. Review.
11. Bechara A (2005) Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Nat Neurosci 8 : 1458 1463.
12. Bickel WK, Marsch LA (2001) Toward a behavioural economic understanding of drug dependence: delay discounting processes. Addiction 96 : 73 86.
13. Bickel WK, Marsch LA, Caroll ME (2000) Deconstructing relative efficacy and situationf the measures of pharmacological reinforcement with behavioural economics: a theoretical proposal. Psychopharmacology 253 : 44 56.
14. Bolla KI, Eldreth DA, London ED, Kiehl KA, Mouratidis M, Contoreggi C, Matochik JA, Kurian V, Cadet JL, Kimes AS, Funderburk FR, Ernst M (2003) Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task. Neuroimage 19 : 1085 1094.
15. Boyle AE, Smith BR, Spivak K, Amit Z (1994) Voluntary ethanol consumption in rats: the importance of the exposure paradigm in determining the final intake outcome. Behav Pharmacol 5 : 502 512.
16. Brown PL, Jenkins HM (1968) Auto-shaping of the pigeon's key-peck. J Exp Anal Behav 11 : 1 8.
17. Bruce KR, Pihl RO (1997) Forget 'drinking to forget': enhanced consolidation of emotionally charged memory by alcohol. Exp Clin Psychopharmacol 5 : 242 250.
18. Brunner D, Hen R (1997) Insight of the neurobiology of impulsive behaviour from serotonin receptor knockout mice. Ann NY Acad Sci 836 : 81 105.
19. Bures J, Bermudez-Rattoni F, Yamamoto T (1998) Conditioned Taste Aversion, Memory of a Special Kind. Oxford Psychology Series. Oxford : Oxford University Press.
20. Burns M, Domjan M (2000) Sign tracking in domesticated quail with one trial a day: generality across CS and US parameters. Anim Learn Behav 28 : 109 119.
21. Caine SB, Lintz R, Koob GF (1993) Intravenous drug self-administration techniques in animals. In : Sahgal A, ed. Behavioural Neuroscience: A Practical Approach, pp. 117 143. New York : Oxford University Press.
22. Campbell UC, Carroll ME (2000) Acquisition of drug self administration: environmental and pharmacological interventions. Exp Clin Psychopharmacol 8 : 312 325.
23. Cardinal RN, Everitt BJ (2004) Neural and psychological mechanisms underlying learning links to drug addiction. Curr Opin Neurobiol 14 : 156 162.
24. Cardinal RN, Winstanley CA, Robbins TW, Everitt BJ (2004) Limbic corticostriatal systems and delayed reinforcement. Ann NY Acad Sci 1021 : 33 50.
25. Carroll ME, Lac ST (1997) Acquisition of i.v. amphetamine and cocaine self-administration in rats as a function of dose. Psychopharmacology 129 : 206 211.
26. Chaudhri N, Caggiula AR, Donny EC, Palmatier MI, Liu X, Sved AF (2006) Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement. Psychopharmacology 184 : 353 366.
27. Ciccocioppo R, Panocka I, Froldi R, Quitadamo E, Massi M (1999) Ethanol induces conditioned place preference in genetically selected alcohol-preferring rats. Psychopharmacology 141 : 235 241.
28. Cloninger CR (1987) A systematic method for clinical description and classification of personality variants. Arch Gen Psychiatry 44 : 573 558.
29. Conklin CA, Tiffany ST (2002) Applying extinction research and theory to cue-exposure addiction treatments. Addiction 97 : 155 167.
30. Critchfield TS, Kollins SH (2001) Temporal discounting: basic research and the analysis of socially important behaviour. J Appl Behav Anal 34 : 101 122.
31. Cryan JF, Hoyer D, Markou A (2003) Withdrawal from chronic amphetamine induces depressive-like behavioural effects in rodents. Biol Psychiatry 54 : 49 58.
32. Cunningham CL, Ferree NK, Howard MA (2003) Apparatus bias and place conditioning with ethanol in mice. Psychopharmacology 170 : 409 422.
33. Cunningham CL, Niehus JS, Noble D (1993) Species difference in sensitivity to ethanol's hedonic effects. Alcohol 10 : 97 102.
34. Cunningham CL, Niehus JS (1997) Flavor preference conditioning by oral self-administration of ethanol. Psychopharmacology 134 : 293 302.
35. Cunningham CL, Okorn DM, Howard CE (1997) Interstimulus interval determines whether ethanol produces conditioned place preference or aversion. Anim Learn Behav 25 : 31 42.
36. Danel T, Toitou Y (2004) Chronobiology of alcohol: from chronokinetics to alcohol-related alterations of the circadian system. Chronobiol Int 21 : 923 935.
37. Davis JD (1996) Deterministic and probabilistic control of the behaviour of rats including liquid diets. Am J Physiol 270 : R793 R800.
38. Davis JD, Levine MW (1977) A model of control of ingestion. Psychol Rev 84 : 379 412.
39. De Wit H, Stewart J (1981) Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology 75 : 134 143.
40. Deroche-Gamonet V, Belin D, Piazza PV (2004) Evidence for addiction-like behaviour in the rat. Science 305 : 1014 1017.
41. Dickinson N, Wood J, Smith JW (2000) Alcohol seeking by rats: action or habit? Q J Exp Psychol 55B : 331 338.
42. Domjan MP (2004) The Essentials of Conditioning and Learning, 3rd edn. Belmont : Wadsworth Publishing.
43. Domjan MP (2005) Pavlovian conditioning: a functional perspective. Annu Rev Psychol 56 : 179 206.
44. Donny EC, Chaudhri N, Caggiula AR, Evans-Martin FF, Booth S, Gharib MA, Clements LA, Sved AF (2003) Operant responding for a visual reinforcer in rats is enhanced by noncontingent nicotine: implications for nicotine self-administration and reinforcement. Psychopharmacology 169 : 68 76.
45. Epping-Jordan MP, Watkins SS, Koob GF, Markou A (1998) Dramatic decreases in brain reward function during nicotine withdrawal. Nature 393 : 76 79.
46. Epstein DH, Preston KL (2003) The reinstatement model and relapse prevention: a clinical perspective. Psychopharmacology 168 : 31 41.
47. Esposito RU, Porrino LJ, Seeger TF, Crane AM, Everist HD, Pert A (1984) Changes in local cerebral glucose utilization during rewarding brain stimulation. Proc Natl Acad Sci USA 81 : 635 639.
48. Ettenberg A (2004) Opponent process properties of self-administered cocaine. Neurosci Biobehav Rev 27 : 721 728.
49. Evangelista AM, Izquierdo I (1971) The effect of pre- and post-trial amphetamine injections on avoidance responses in rats. Psychopharmacology 20 : 40 47.
50. Evenden JL (1999) Varieties of impulsivity. Psychopharmacology 146 : 348 361.
51. Everitt BJ, Dickinson A, Robbins TW (2001) The neuropsychological basis of addictive behaviour. Brain Res Rev 36 : 129 138.
52. Everitt BJ, Robbins TW (2000) Second-order schedules of drug reinforcement in rats and monkeys: measurement of reinforcing efficacy and drug-seeking behaviour. Psychopharmacology (Berl) 153 : 17 30. Review.
53. Everitt BJ, Robbins TW (2005) Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 8 : 1481 1489.
54. Eysenck SGB (1993) The I7: development of a measure of impulsivity and its relationship to the superfactors of personality. In : McCown WG, Johnson JL, Shure MB, eds. The Impulsive Client: Theory, Research and Treatment. Washington DC : American Psychological Association.
55. Fachin-Scheit DJ, Frozino Ribeiro A, Pigatto G, Oliveira Goeldner F, Boerngen de Lacerda R (2006) Development of a mouse model of ethanol addiction: naltrexone efficacy in reducing consumption but not craving. J Neural Transm. Published online [DOI: 10.1007/s00702-005-0416-z].
56. Falk JL, Lau CE (1997) Establishing preference for oral cocaine without an associative history with a reinforcer. Drug Alcohol Depend 46 : 159 166.
57. Files FJ, Lewis RS, Samson HH (1994) Effects of continuous versus limited access to ethanol on ethanol self-administration. Alcohol 11 : 523 531.
58. Flaherty CF, Checke S (1982) Anticipation of incentive gain. Anim Learn Behav 10 : 177 182.
59. Font L, Miquel M, Aragon CMG (2006) Ethanol-induced conditioned place preference, but not aversion, is blocked by treatment with d-penicillamine, an inactivation agent for acetaldehyde. Psychopharmacology 184 : 56 64.
60. Fudala PJ, Iwamoto ET (1990) Conditioned aversion after delay place conditioning with amphetamine. Pharmacol Biochem Behav 35 : 89 92.
61. Gallistel CR, Fairhurst S, Balsam P (2004) The learning curve: implications of a quantitative analysis. Proc Natl Scad Sci USA 36 : 13124 13131.
62. Garcia J, Hankins WG, Rusiniak KW (1974) Behavioural regulation of milieu interne in man and rat. Science 185 : 824 831.
63. Gill K, Amit Z, Smith BR (1996) The regulation of alcohol consumption in rats: the role of alcohol-metabolizing enzymes-catalase and aldehyde dehydrogenase. Alcohol 13 : 347 353.
64. Glasner R, Overmier JB, Balleine BW (2005) The role of Pavlovian cues in alcohol seeking in dependent and non-dependent rats. J Stud Alcohol 42 : 53 61.
65. Grant S, Contoreggi C, London ED (2000) Drug abusers show impaired performance in a laboratory test of decision making. Neuropsychologia 38 : 1180 1187.
66. Griffiths RR, Brady JV, Bradford LD (1979) Predicting the abuse liability of drugs and animal drug self-administration procedures: psychomotor stimulants and hallucinogens. In : Thompson T, Dews PB, eds. Advances in Behavioural Pharmacolog, Vol. 2, pp. 163 208. New York : Academic Press.
67. Heather N, Vuchinich RE (2003) Choice, Behavioural Economics and Addiction. Oxford : PERGAMON.
68. Herrnstein RJ (1970) On the law of the effect. J Exp Anal Behav 13 : 243 266.
69. Herzig V, Schmidt WJ (2005) Anti-craving drugs acamprosate and naloxone do not reduce expression of morphine conditioned place preference in isolated and group-housed rats. Neurosci Lett 347 : 19 23.
70. Heyman GM (2003) Consumption dependent changes in reward value: a framework for understanding addiction. In : Heather N, Vuchinich RE, eds. Choice, Behavioural Economics and Addiction, pp. 95 122. Oxford : Elsevier.
71. Heyne A (1996) The development of opiate addiction in the rat. Pharm Biochem Behav 53 : 11 25.
72. Heyne A, May T, Goll P, Wolffgramm J (2000) Persisting consequences of drug intake: towards a memory of addiction. J Neural Transm 107 : 613 618.
73. Heyne A, Wolffgramm J (1998) The development of addiction to d-amphetamine in an animal model: the same principles as for alcohol and opiate. Psychopharmacology 140 : 510 518.
74. Ho MY, Mobini S, Chiang TJ, Bradshaw C, Szabadi E (1999) Theory and method in the quantitative analysis of 'impulsive choice behaviour': implications for psychopharmacology. Psychopharmacology 146 : 362 372.
75. Holland PC (2004) Relations between pavlovian-instrumental transfer and reinforcer devaluation. J Exp Psychol 30 : 104 117.
76. Hölter SM, Engelmann M, Kirschke C, Liebsch G, Landgraf R, Spanagel R (1998) Long-term ethanol self-administration with repeated ethanol deprivation episodes changes ethanol drinking pattern and increases anxiety-related behaviour during ethanol deprivation in rats. Behav Pharmacol 9 : 41 48.
77. Hunt T, Amit Z (1987) Conditioned taste aversion induced by self-administered drugs: paradox revisited. Neurosci Biobehav Rev 11 : 107 130.
78. Hyman SE (2005) Addiction: a disease of learning and memory. Am J Psychiatry 162 : 1414 1422.
79. Hyman SE, Malenka RC (2001) Addiction and the brain: the neurobiology of compulsion and its persistence. Nat Rev Neurosci 2 : 695 703.
80. Itzhak Y, Martin JL (2002) Cocaine-induced conditioned place preference in mice: induction, extinction and reinstatement by related psychostimulants. Neuropsychopharmacology 26 : 130 134.
81. Jackson HC, Nutt DJ (1993) A single preexposure produces sensitization to the locomotor effects of cocaine in mice. Pharmacol Biochem Behav 45 : 733 735.
82. Jenkins HM, Moore BR (1973) The form of the autoshaped response with food or water reinforcers. J Exp Anal Behav 20 : 163 181.
83. Kalivas PW (2005) How we do determine which drug-induced neuroplastic changes are important? Nat Neurosci 8 : 1440 1441.
84. Kampov-Polevoy AB, Matthews DB, Gause L, Morrow AL, Overstreet DH (2000) P rats develop physical dependence on alcohol via voluntary drinking: changes in seizure thresholds, anxiety, and patterns of alcohol drinking. Alcohol Clin Exp Res 24 : 278 824.
85. Katner SN, Magalong JG, Weiss F (1999) Reinstatement of alcohol-seeking behaviour by drug-associated discriminative stimuli after prolonged extinction in the rat. Neuropsychopharmacology 20 : 471 479.
86. Kearns DN, Weiss SJ (2004) Sign-tracking (autoshaping) in rats: a comparison of cocaine and food as unconditioned stimuli. Learn Behav 32 : 463 476.
87. Kelley AE, Schochet T, Landry CF (2004) Risk taking and novelty seeking in adolescence: introduction to part I. Ann NY Acad Sci 1021 : 27 32.
88. Kiefer F, Wiedemann W (2004) Neuroendocrine pathways of addictive behaviour. Addict Biol 9 : 205 212.
89. Kirby KN, Petry NM (2004) Heroin addicts and cocaine abusers have higher discount rates for delayed rewards than alcoholics or non-drug-using controls. Addiction 99 : 467 471.
90. Koob GF (2000) Animal models of craving for ethanol. Addiction 95 : S73 S81. Review.
91. Koob GF, Ahmed SH, Boutrel B, Chen SA, Kenny PJ, Markou A, O'Dell LE, Parsons LH, Sanna PP (2004) Neurobiological mechanisms in the transition from drug use to drug dependence. Neurosci Biobehav Rev 27 : 739 749.
92. Koob GF, Le Moal M (2005) Plasticity of reward neurocircuitry and the 'dark side of drug addiction. Nat Neurosci 8 : 1442 1444.
93. Kopf SR, Melani A, Pedata F, Pepeu G (1999) Adenosine and memory storage. Psychopharmacology 102 : 117 125.
94. Kornetsky C, Bain G (1992) Brain-stimulation reward: a model for the study of the rewarding effects of abused drugs. Nida Res Monogr 124 : 72 93.
95. Krank MD (2003) Pavlovian conditioning with ethanol: sign-tracking (autoshaping), conditioned incentive, and ethanol self-administration. Alcohol Clin Exp Res 27 : 1592 1598.
96. Kreek MJ, Nielsen DA, Butelman ER, LaForge KS (2005) Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nat Neurosci 8 : 1450 1457.
97. Kuzmin A, Sandin J, Terenius L, Ogren SO (2003) Acquisition, expression, and reinstatement of ethanol-induced conditioned place preference in mice: effects of opioid receptor-like 1 receptor agonists and naloxone. J Pharmacol Exp Ther 304 : 310 318.
98. Larimer ME, Palmer RS, Marlatt GA 1999) Relapse prevention: an overview of Marlatt's cognitive-behavioural model. Alcohol Res Health 23 : 151 160.
99. Le A, Shaham Y (2002) Neurobiology of relapse to alcohol in rats. Pharmacol Ther 94 : 137 156.
100. Le Magnen J (1960) Etude de quelques facteurs associes à des modifications de la consommation spontanée d'alcohol éthylique par le rat. J Physiol Paris 52 : 873 884.
101. LeFoll B, Goldberg SR (2006) Nicotine as a typical drug of abuse in experimental animals and humans. Psychopharmacology. Published online [DOI 10.1007/s00213-005-0155-8].
102. Lett BT, Grant VL (1989) Conditioned taste preference produced by pairing a taste with a low dose of morphine or sufentanil. Psychopharmacology 98 : 236 239.
103. Levin ED, Simon BB (1998) Nicotinic acetylcholine involvement in cognitive function in animals. Psychopharmacology 138 : 217 230.
104. Li TK, Volkow N (2005) The neuroscience of addiction. Nat Neurosci 8 : 1429 1430.
105. Liu X, Weiss F (2002) Additive effect of stress and drug cues on reinstatement of ethanol seeking: exacerbation by history of dependence and role of concurrent activation of corticotropin-releasing factor and opioid mechanisms. J Neurosci 22 : 7856 7861.
106. Manrique HM, Miquel M, Aragon CMG (2005) Brain catalase mediates potentiation of social recognition memory produced by ethanol in mice. Drug Alcohol Depend 79 : 343 350.
107. Marcucella H, Munro I (1986) Patterns of ethanol and water consumption as a function of ethanol restricted access and feeding condition. Psychopharmacology 89 : 145 149.
108. Marcucella H, Munro I, MacDonall JS (1984) Patterns of ethanol consumption as a function of the schedule of ethanol access. J Pharmacol Exp Ther 230 : 658 664.
109. Markou A, Koob GF (1993) Intracraneal self-stimulation thresholds as a measure of reward. In : Sahgal A, ed. Behavioural Neuroscience: A Practical Approach, pp. 93 115. Oxford, New York : University Press.
110. Markou A, Weiss F, Gold LH, Caine SB, Schulteis G, Koob GF (1993) Animal models of drug craving. Psychopharmacology 112 : 163 182. Review.
111. Martinetti MP, Andrzejewski ME, Hineline PN, Lewis MJ (2000) Ethanol consumption and the matching law: a choice analysis using a limited-access paradigm. Exp Clin Psychopharmacol 8 : 395 403.
112. Mazur JE (1986) Choice between single and multiple delayed reinforcers. J Exp Anal Behav 46 : 67 77.
113. Mazur JE (2001) Hyperbolic value addition and general models of animal choice. Psychol Rev 108 : 96 112.
114. McBride WJ, Li TK (1998) Animal models of alcoholism: neurobiology of high alcohol-drinking behaviour in rodents. Crit Rev Neurobiol 12 : 339 369.
115. McFarland K, Ettenberg A (1997) Reinstatement of drug-seeking behaviour produced by heroin-predictive environmental stimuli. Psychopharmacology 131 : 86 92.
116. McGaugh JL (1989) Dissociating learning and performance: drug and hormone enhancement of memory storage. Brain Res Bull 23 : 339 345.
117. McGeehan AJ, Olive MF (2003) The anti-relapse compound acamprosate inhibits the development of a conditioned place preference to ethanol and cocaine but not morphine. Br J Pharmacol 138 : 9 12.
118. McGregor IS, Saharov T, Hunt GE, Topple AN (1999) Beer consumption in rats: the influence of ethanol content, food deprivation, and cocaine. Alcohol 17 : 47 56.
119. Mead AN, Brown G, Le Merrer J, Stephens DN (2005) Effects of deletion of Gria1 or Gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in mice. Psychopharmacology 179 : 164 171.
120. Meisch RA (2001) Oral drug self-administration: an overview of laboratory animal studies. Alcohol 24 : 117 128.
121. Meliska CJ, Bartke A, McGlacken G, Jensen RA (1995) Ethanol, nicotine, amphetamine, and aspartame consumption and preferences in C57BL/6 and DBA/2 mice. Pharmacol Biochem Behav 50 : 619 626.
122. Michel A, Tirelli E (2002) Conditioned hyperkinesia induced by cocaine in mice is dose-dependent but not correlated with the unconditioned response or the contextually-sensitized response. Behav Pharmacol 13 : 59 63.
123. Miles BJ, Everitt BJ, Dickinson A (2003) Oral cocaine seeking by rats: action or habit? Behav Neurosci 117 : 927 938.
124. Millan MJ, Brocco M (2003) The vogel conflict test: procedural aspects, gamma-aminobutyric acid, glutamate and monoamines. Eur J Pharmacol 463 : 67 96.
125. Montague PR, Hyman SE, Cohen JD (2004) Computational roles for dopamine in behavioural control. Nature 431 : 760 766.
126. Monterosso J, Ainslie G (1999) Beyond discounting: possible experimental models of impulse control. Psychopharmacology 146 : 339 347.
127. Morgan D, Brebner K, Lynch WJ, Roberts DC (2002) Increases in the reinforcing efficacy of cocaine after particular histories of reinforcement. Behav Pharmacol 13 : 389 396.
128. Nestler EJ (2005) Is there a common molecular pathway for addiction? Nat Neurosci 8 : 1445 1449.
129. Newlin DB (1992) A comparison of drug conditioning and craving for alcohol and cocaine. Recent Dev Alcohol 10 : 147 164.
130. Olds J, Milner P (1954) Positive reinforcement produced by electrical stimulation of septal area and other regions of the rat brain. J Comp Physiol Psychol 47 : 419 427.
131. Palmatier MI, Evans-Martin FF, Hoffman A, Caggiula AR, Chaudhri N, Donny EC, Liu X, Booth S, Gharib M, Sved AF (2006) Dissociating the primary reinforcing and reinforcement-enhancing effects of nicotine using a rat self-administration paradigm with concurrently available drug and environmental reinforcers. Psychopharmacology 184 : 391 400.
132. Parker LA (1993) Rewarding drugs produce taste avoidance, but not taste aversion. Neurosci Biobehav Rev 19 : 143 157.
133. Parker LA (2003) Taste avoidance and taste aversion: evidence for two different processes. Learn Behav 31 : 165 172.
134. Patton JH, Standford MS, Barratt ES (1995) Factor structure of the Barratt impulsiveness scale. J Clin Psychol 51 : 768 774.
135. Porrino LJ, Esposito RU, Seeger TF, Crane AM, Pert A, Sokoloff L (1984) Metabolic mapping of the brain during rewarding self-stimulation. Science 224 : 306 309.
136. Prediger RD, Takahashi RN (2003) Ethanol improves short-term social memory in rats. Involvement of the opioid and muscarinic receptors. Eur J Pharmacol 462 : 115 123.
137. Richardson NJ, Rogers PJ, Elliman NA (1996) Conditioned flavor preferences reinforced by caffeine consumed after lunch. Physiol Behav 60 : 257 263.
138. Robinson TE, Berridge KC (1998) What is the role of dopamine in reward: hedonic impact, reward learning or incentive salience. Brain Res Brain Res Rev 28 : 309 369.
139. Robinson TE, Berridge KC (2003) Addiction. Annu Rev Psychol 54 : 25 53.
140. Rowlett JK (2000) A labor-supply analysis of cocaine self-administration under progressive-ratio schedules: antecedents, methodologies, and perspectives. Psychopharmacology (Berl) 153 : 1 16.
141. Salamone JD, Correa M (2002) Motivational views of reinforcement: implications for understanding the behavioural functions of nucleus accumbens dopamine. Behav Brain Res 137 : 3 25.
142. Salamone JD, Correa M, Mingote S, Weber SM (2003) Nucleus accumbens dopamine and the regulation of effort in food-seeking behaviour: implications for studies of natural motivation, psychiatry, and drug abuse. J Pharmacol Exp Ther 305 : 1 8.
143. Salamone JD, Correa M, Mingote S, Weber S (2005) Beyond the reward hypothesis: alternative functions of nucleus Accumbens dopamine. Curr Opin Pharmacol 5 : 34 41.
144. Samaha AN, Robinson TE (2005) Why does the rapid delivery of drugs to the brain promote addiction? Trends Pharmacol Sci 26 : 82 87.
145. Samson HH, Czachowski CL, Slawecki CJ (2000) A new assessment of the ability of oral ethanol to function as a reinforcing stimulus. Alcohol Clin Exp Res 24 : 766 773.
146. Sanchis-Segura C, Cline BH, Marsicano G, Lutz B, Spanagel R (2004) Sensitivity to reward in CB1 knockout mice. Psychopharmacology (Berl) 176 : 223 232.
147. Sanchis-Segura C, Spanagel R, Henn FA, Vollmayr B (2005) Sensitivity to sucrose in rats bred for helplessness: a study using the matching law. Behav Pharmacol 16 : 267 270.
148. Sax KW, Strakowski SM (2001) Behavioural sensitization in humans. J Addict Dis 20 : 55 65.
149. Schindler CW, Panlilio LV, Goldberg SR (2002) Second-order schedules of drug self-administration in animals. Psychopharmacology 163 : 327 344.
150. Schulteis G, Markou A, Cole M, Koob GF (1995) Decreased brain reward produced by ethanol withdrawal. Proc Natl Acad Sci USA 92 : 5880 5884.
151. Schuster CR, Smith BB, Jaffe JH (1971) Drug abuse in heroin users. An experimental study of self-administration of methadone, codeine, and pentazocine. Arch Gen Psychiatry 24 : 359 362.
152. Seligman MEP (1970) On the generality of the laws of learning. Psychol Rev 77 : 406 418.
153. Shaham Y, Hope BT (2005) The role of neuroadaptations in relapse to drug-seeking. Nat Neurosci 8 : 1437 1439.
154. Shaham Y, Miczek KA (2003) Reinstatement: towards a model of relapse. Psychopharmacology (Berl) 168 : 1 2.
155. Shaham Y, Shalev U, Lu L, De Wit H, Stewart J (2003) The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology (Berl) 168 : 3 20.
156. Shalev U, Yap J, Shaham Y (2001) Leptin attenuates acute food deprivation-induced relapse to heroin seeking. J Neurosci 21 : RC129.
157. Sinclair JD, Senter RJ (1968) Development of an alcohol deprivation effect in rats. Q J Stud Alcohol 29 : 863 867.
158. Sinclair JD, Sheaff B (1973) A negative alcohol-deprivation effect in hamsters. Q J Stud Alcohol 34 : 71 77.
159. Slifer BL (1983) Schedule-induction of nicotine self-administration. Pharmacol Biochem Behav 19 : 1005 1009.
160. Sorge RE, Fudge MA, Parker LA (2002) Effect of sodium deprivation on morphine- and lithium-induced conditioned salt-avoidance and taste reactivity. Psychopharmacology 160 : 84 91.
161. Spanagel R (2000) Recent animal models of alcoholism. Alcohol Res Health 24 : 124 131.
162. Spanagel R, Hölter S (1999) Long-term alcohol self-administration with repeated alcohol deprivation phases: an animal model of alcoholism? Alcohol Alcohol 34 : 231 243.
163. Spanagel R, Holter SM (2000) Pharmacological validation of a new animal model of alcoholism. J Neural Transm 107 : 669 680.
164. Spanagel R, Hölter SM, Allingham K, Landgraf R, Zieglgänsberger W (1996) Acamprosate and alcohol: I. Effects on alcohol intake following alcohol deprivation in the rat. Eur J Pharmacol 305 : 39 44.
165. Spanagel R, Pendyala G, Abarca C, Zghoul T, Sanchis-Segura C, Magnone MC, Lascorz J, Depner M, Holzberg D, Soyka M, Schreiber S, Matsuda F, Lathrop M, Schumann G, Albrecht U (2005) The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nat Med 11 : 35 42.
166. Spanagel R, Sanchis-Segura C (2003) The use of transgenic mice to study addictive behaviour. Clin Neurosci Res 3 : 325 331.
167. Spanagel R, Weiss F (1999) The dopamine hypothesis of reward: past and current status. Trends Neurosci 22 : 521 527.
168. Spanagel R, Zieglgänsberger W (1997) Anti-craving compounds for ethanol: new pharmacological tools to study addictive processes. Trends Pharmacol Sci 18 : 54 59.
169. Stellar JR, Stellar E (1985) Neurobiology of Reward and Motivation. New York : Springer-Verlag.
170. Stewart RB, Grupp LA (1986) Conditioned place aversion mediated by orally self-administered ethanol in the rat. Pharmacol Biochem Behav 24 : 1369 1375.
171. Strecht R, Gerber GJ, Wood SM (1971) Factors affecting behaviour maintained by response contingent intravenous infusions of amphetamine in Squirrel monkeys. Can J Physiol Pharmacol 49 : 581 589.
172. Sugrue LP, Corrado GS, Newsome WT (2005) Choosing the greater of two goods: neural currencies for valuation and decision making. Nat Rev Neurosci 6 : 363 375.
173. Sutton MA, Schmidt EF, Choi KH, Schad CA, Whisler K, Simmons D, Karanian DA, Monteggia LM, Neve RL, Self DW (2003) Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. Nature 421 : 70 85.
174. Swank MW, Schafe GE, Bernstein IL (1995) C-fos induction in response to taste stimuli previously paired with amphetamine or LiCl during taste aversion learning. Brain Res 67 : 257 261.
175. Szumlinski KK, Price KL, Frys KA, Middaugh LD (2002) Unconditioned and conditioned factors contribute to the 'reinstatement' of cocaine place conditioning following extinction in C57BL/6 mice. Behav Brain Res 136 : 151 160.
176. Thorndike EL (1911) Animal Intelligence. New York : MacMillan.
177. Tiffany ST (1999) Cognitive concepts of craving. Alcohol Res Health 23 : 215 224.
178. Tiffany ST, Conklin CA (2000) A cognitive processing model of alcohol craving and compulsive alcohol use. Addiction 95 (Suppl) 2 : S145 153.
179. Todtenkopf MS, Marcus JS, Portoghese PS, Carlezon WA Jr (2004) Effects of kappa-opioid receptor ligands on intracranial self-stimulation in rats. Psychopharmacology 172 : 463 470.
180. Tomie A (2001) Autoshaping and drug-taking. In : Mowrer RR, Klein SB, eds. Handbook of Contemporary Learning Theories, pp. 409 439. Hillsdale, NJ : Erlbaum.
181. Tomie A, Di Poce J, Derenzo CC, Pohorecky LA (2002) Autoshaping of ethanol-drinking: an animal model of binge drinking. Alcohol Alcohol 37 : 138 146.
182. Tordoff MG, Bachmanov AA (2003) Influence of the number of alcohol and water bottles on murine alcohol intake. Alcohol Clin Exp Res 27 : 600 606.
183. Turenne SD, Miles C, Parker LA, Siegel S (1996) Individual differences in reactivity to the rewarding/aversive properties of drugs: assessment by taste and place conditioning. Pharmacol Biochem Behav 53 : 511 516.
184. Tzschentke TM (1998) Reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues. Prog Neurobiol 56 : 613 672.
185. Uzum G, Diler AS, Bahcekapili N, Tasyurekli M, Ziylan YZ (2004) Nicotine improves learning and memory in rats: morphological evidence for acetylcholine involvement. Int J Neurosci 114 : 1163 1179.
186. Van der Boss R, Lasthuis W, Spruijt B (2005) Towards a rodent model of the Iowa Gambling Task. Short paper presented in Measuring Behaviour 2005. Wageningen (The Netherlands).
187. Vanderschuren LJ, De Vries TJ, Wardeh G, Hogenboom FA, Schoffelmeer AN (2001) A single exposure to morphine induces longlasting behavioural and neurochemical sensitization in rats. Eur J Neurosci 14 : 1533 1538.
188. Vanderschuren JMJL, Everitt BJ (2004) Drug seeking becomes compulsive after prolonged cocaine self-administration. Science 305 : 1017 1020.
189. Vanderschuren LJ, Everitt BJ (2005) Behavioural and neural mechanism of compulsive drug seeking. Eur J Pharmacol 526 : 77 88.
190. Vezina P (2004) Sensitization of midbrain dopamine neuron reactivity and the self-administration of psychomotor stimulant drugs. Neurosci Biobehav Rev 27 : 827 839.
191. Waelti P, Dickinson A, Schultz W (2001) Dopamine responses comply with basic assumptions of formal learning theory. Nature 412 : 43 48.
192. White NM (1996) Addictive drugs as reinforcers: multiple partial actions on memory systems. Addiction 91 : 921 949.
193. White NM, Milner PM (1992) The psychobiology of reinforcers. Annu Rev Psychol 43 : 433 471.
194. Winstanley CA, Dalley KW, Theobald DEH, Robbins TW (2004) Fractionating impulsivity: contrasting effects of central 5-HT depletion on different measures of impulsive behaviour. Neuropsychopharmacology 29 : 1331 1343.
195. Wise RA (1996) Addictive drugs and brain stimulation reward. Annu Rev Neurosci 19 : 319 340.
196. Wolffgramm J, Heyne A (1995) From controlled drug intake to loss of control: the irreversible development of drug addiction in the rat. Behav Brain Res 70 : 77 94.
197. Wyvel CL, Berridge KC (2000) Intra-accumbens amphetamine increase the conditioned salience of sucrose reward: enhancement of reward 'wanting' without enhanced 'liking' or response reinforcement. J Neurosci 20 : 8122 8130.
198. Wyvel CL, Berridge KC (2001) Incentive sensitization by previous amphetamine exposure: increased cue-triggered 'wanting' for sucrose reward. J Neurosci 21 : 7831 7840.
199. Yeomans MR, Jackson A, Lee MD, Durlach PJ (2000) Expression of flavour preferences conditioned by caffeine is dependent on caffeine deprivation state. Psychopharmacology 150 : 208 215.