메뉴 건너뛰기




Volumn 181, Issue , 2011, Pages 1-17

Neurochemical basis of cannabis addiction

Author keywords

CB1 receptor; Dopamine; Opioid; Reward; THC; Tolerance

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCHOLINE; ADENOSINE; ADRENALIN; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABIS; CORTICOTROPIN RELEASING FACTOR; DOPAMINE; GLUTAMIC ACID; NORADRENALIN; OPIATE; OXYTOCIN; SEX HORMONE;

EID: 79953675661     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2011.02.035     Document Type: Review
Times cited : (91)

References (213)
  • 2
    • 0035937453 scopus 로고    scopus 로고
    • Spontaneous and precipitated withdrawal with a synthetic cannabinoid, WIN 55,212-2
    • Aceto M.D., Scates S.M., Lowe J.A., Martin B.P. Spontaneous and precipitated withdrawal with a synthetic cannabinoid, WIN 55,212-2. Eur J Pharmacol 2001, 416:75-81.
    • (2001) Eur J Pharmacol , vol.416 , pp. 75-81
    • Aceto, M.D.1    Scates, S.M.2    Lowe, J.A.3    Martin, B.P.4
  • 3
    • 0017068782 scopus 로고
    • Tolerance to the cardiovascular effects of delta9-tetrahydrocannabinol in the rat
    • Adams M.D., Chait L.D., Earnhardt J.T. Tolerance to the cardiovascular effects of delta9-tetrahydrocannabinol in the rat. Br J Pharmacol 1976, 56:43-48.
    • (1976) Br J Pharmacol , vol.56 , pp. 43-48
    • Adams, M.D.1    Chait, L.D.2    Earnhardt, J.T.3
  • 5
    • 0003790105 scopus 로고    scopus 로고
    • AIHW, Australian Institute of Health and Welfare, AIHW cat. no. PHE 57, AIHW, Canberra, (Drug Statistics Series No. 13)
    • 2004 National Drug Strategy Household Survey: First Results 2005, AIHW, Australian Institute of Health and Welfare, AIHW cat. no. PHE 57, AIHW, Canberra, (Drug Statistics Series No. 13).
    • (2005) 2004 National Drug Strategy Household Survey: First Results
  • 6
    • 0036867665 scopus 로고    scopus 로고
    • Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids
    • Alger B.E. Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids. Prog Neurobiol 2002, 68:247-286.
    • (2002) Prog Neurobiol , vol.68 , pp. 247-286
    • Alger, B.E.1
  • 8
    • 77952623444 scopus 로고    scopus 로고
    • CB2: a cannabinoid receptor with an identity crisis
    • Atwood B.K., Mackie K. CB2: a cannabinoid receptor with an identity crisis. Br J Pharmacol 2010, 160:467-479.
    • (2010) Br J Pharmacol , vol.160 , pp. 467-479
    • Atwood, B.K.1    Mackie, K.2
  • 9
  • 10
    • 33645074703 scopus 로고    scopus 로고
    • AATn repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population
    • Ballon N., Leroy S., Roy C., Bourdel M.C., Charles-Nicolas A., Krebs M.O., Poirier M.F. AATn repeat in the cannabinoid receptor gene (CNR1): association with cocaine addiction in an African-Caribbean population. Pharmacogenomics J 2006, 6:126-130.
    • (2006) Pharmacogenomics J , vol.6 , pp. 126-130
    • Ballon, N.1    Leroy, S.2    Roy, C.3    Bourdel, M.C.4    Charles-Nicolas, A.5    Krebs, M.O.6    Poirier, M.F.7
  • 11
    • 0000688590 scopus 로고
    • Perception of drug effects
    • John Wiley and Sons, New York, M.A. Berkley, W.C. Stebbins (Eds.)
    • Balster R.L. Perception of drug effects. Comparative perception vol. I. Basics mechanims 1990, 127-154. John Wiley and Sons, New York. M.A. Berkley, W.C. Stebbins (Eds.).
    • (1990) Comparative perception vol. I. Basics mechanims , pp. 127-154
    • Balster, R.L.1
  • 12
    • 0028958518 scopus 로고
    • Pharmacological specificity of delta 9-tetrahydrocannabinol discrimination in rats
    • Barrett R.L., Wiley J.L., Balster R.L., Martin B.R. Pharmacological specificity of delta 9-tetrahydrocannabinol discrimination in rats. Psychopharmacology (Berl) 1995, 118:419-424.
    • (1995) Psychopharmacology (Berl) , vol.118 , pp. 419-424
    • Barrett, R.L.1    Wiley, J.L.2    Balster, R.L.3    Martin, B.R.4
  • 14
    • 45549086741 scopus 로고    scopus 로고
    • High impulsivity predicts the switch to compulsive cocaine-taking
    • Belin D., Mar A.C., Dalley J.W., Robbins T.W., Everitt B.J. High impulsivity predicts the switch to compulsive cocaine-taking. Science 2008, 320:1352-1355.
    • (2008) Science , vol.320 , pp. 1352-1355
    • Belin, D.1    Mar, A.C.2    Dalley, J.W.3    Robbins, T.W.4    Everitt, B.J.5
  • 15
    • 78649976095 scopus 로고    scopus 로고
    • CNR1 gene polymorphisms in addictive disorders: a systematic review and a meta-analysis
    • Benyamina A., Kebir O., Blecha L., Reynaud M., Krebs M.O. CNR1 gene polymorphisms in addictive disorders: a systematic review and a meta-analysis. Addict Biol 2011, 16(1):1-6.
    • (2011) Addict Biol , vol.16 , Issue.1 , pp. 1-6
    • Benyamina, A.1    Kebir, O.2    Blecha, L.3    Reynaud, M.4    Krebs, M.O.5
  • 16
    • 42349088314 scopus 로고    scopus 로고
    • Endogenous cannabinoids: structure and metabolism
    • Bisogno T. Endogenous cannabinoids: structure and metabolism. J Neuroendocrinol 2008, 20(Suppl 1):1-9.
    • (2008) J Neuroendocrinol , vol.20 , Issue.SUPPL 1 , pp. 1-9
    • Bisogno, T.1
  • 17
    • 0035800002 scopus 로고    scopus 로고
    • Conditioned place preference induced by the cannabinoid agonist CP 55,940: interaction with the opioid system
    • Braida D., Pozzi M., Cavallini R., Sala M. Conditioned place preference induced by the cannabinoid agonist CP 55,940: interaction with the opioid system. Neuroscience 2001, 104:923-926.
    • (2001) Neuroscience , vol.104 , pp. 923-926
    • Braida, D.1    Pozzi, M.2    Cavallini, R.3    Sala, M.4
  • 18
    • 0035895535 scopus 로고    scopus 로고
    • Intracerebral self-administration of the cannabinoid receptor agonist CP 55,940 in the rat: interaction with the opioid system
    • Braida D., Pozzi M., Parolaro D., Sala M. Intracerebral self-administration of the cannabinoid receptor agonist CP 55,940 in the rat: interaction with the opioid system. Eur J Pharmacol 2001, 413:227-234.
    • (2001) Eur J Pharmacol , vol.413 , pp. 227-234
    • Braida, D.1    Pozzi, M.2    Parolaro, D.3    Sala, M.4
  • 19
    • 9644255633 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol-induced conditioned place preference and intracerebroventricular self-administration in rats
    • Braida D., Iosuè S., Pegorini S., Sala M. Delta9-tetrahydrocannabinol-induced conditioned place preference and intracerebroventricular self-administration in rats. Eur J Pharmacol 2004, 506:63-69.
    • (2004) Eur J Pharmacol , vol.506 , pp. 63-69
    • Braida, D.1    Iosuè, S.2    Pegorini, S.3    Sala, M.4
  • 21
    • 33645421778 scopus 로고    scopus 로고
    • Chronic exposure to Delta9-tetrahydrocannabinol downregulates oxytocin and oxytocin-associated neurophysin in specific brain areas
    • Butovsky E., Juknat A., Elbaz J., Shabat-Simon M., Eilam R., Zangen A., Altstein M., Vogel Z. Chronic exposure to Delta9-tetrahydrocannabinol downregulates oxytocin and oxytocin-associated neurophysin in specific brain areas. Mol Cell Neurosci 2006, 31:795-804.
    • (2006) Mol Cell Neurosci , vol.31 , pp. 795-804
    • Butovsky, E.1    Juknat, A.2    Elbaz, J.3    Shabat-Simon, M.4    Eilam, R.5    Zangen, A.6    Altstein, M.7    Vogel, Z.8
  • 22
    • 33645034385 scopus 로고    scopus 로고
    • Cannabinoid modulation of opiate reinforcement through the ventral striatopallidal pathway
    • Caillé S., Parsons L.H. Cannabinoid modulation of opiate reinforcement through the ventral striatopallidal pathway. Neuropsychopharmacology 2006, 31:804-813.
    • (2006) Neuropsychopharmacology , vol.31 , pp. 804-813
    • Caillé, S.1    Parsons, L.H.2
  • 23
    • 0037232392 scopus 로고    scopus 로고
    • Cannabinoid withdrawal syndrome is reduced in double mu and delta opioid receptor knockout mice
    • Castañé A., Robledo P., Matifas A., Kieffer B.L., Maldonado R. Cannabinoid withdrawal syndrome is reduced in double mu and delta opioid receptor knockout mice. Eur J Neurosci 2003, 17:155-159.
    • (2003) Eur J Neurosci , vol.17 , pp. 155-159
    • Castañé, A.1    Robledo, P.2    Matifas, A.3    Kieffer, B.L.4    Maldonado, R.5
  • 25
    • 0031780582 scopus 로고    scopus 로고
    • Involvement of central cannabinoid (CB1) receptors in the establishment of place conditioning in rats
    • Chaperon F., Soubrie P., Puech A.J., Thiebot M.H. Involvement of central cannabinoid (CB1) receptors in the establishment of place conditioning in rats. Psychopharmacology 1998, 135:324-332.
    • (1998) Psychopharmacology , vol.135 , pp. 324-332
    • Chaperon, F.1    Soubrie, P.2    Puech, A.J.3    Thiebot, M.H.4
  • 26
    • 0034706069 scopus 로고    scopus 로고
    • Lack of response suppression follows repeated ventral tegmental cannabinoid administration: an in vitro electrophysiological study
    • Cheer J.F., Marsden C.A., Kendall D.A., Mason R. Lack of response suppression follows repeated ventral tegmental cannabinoid administration: an in vitro electrophysiological study. Neuroscience 2000, 99:661-667.
    • (2000) Neuroscience , vol.99 , pp. 661-667
    • Cheer, J.F.1    Marsden, C.A.2    Kendall, D.A.3    Mason, R.4
  • 27
    • 0025161255 scopus 로고
    • Delta9-tetrahydrocannabinol produces naloxone-blockable enhancement of presynaptic basal dopamine efflux in nucleus accumbens of conscious, freely-moving rats as measured by intracerebral microdialysis
    • Chen J., Paredes W., Li J., Smith D., Lowinson J., Gardner E.L. Delta9-tetrahydrocannabinol produces naloxone-blockable enhancement of presynaptic basal dopamine efflux in nucleus accumbens of conscious, freely-moving rats as measured by intracerebral microdialysis. Psychopharmacology 1990, 102:156-162.
    • (1990) Psychopharmacology , vol.102 , pp. 156-162
    • Chen, J.1    Paredes, W.2    Li, J.3    Smith, D.4    Lowinson, J.5    Gardner, E.L.6
  • 28
    • 3042651241 scopus 로고    scopus 로고
    • DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine
    • Cheng H.Y., Laviolette S.R., van der Kooy D., Penninger J.M. DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine. Eur J Neurosci 2004, 19:3033-3041.
    • (2004) Eur J Neurosci , vol.19 , pp. 3033-3041
    • Cheng, H.Y.1    Laviolette, S.R.2    van der Kooy, D.3    Penninger, J.M.4
  • 30
    • 67651028422 scopus 로고    scopus 로고
    • Cannabis use disorder: epidemiology and management
    • Copeland J., Swift W. Cannabis use disorder: epidemiology and management. Int Rev Psychiatry 2009, 21:96-103.
    • (2009) Int Rev Psychiatry , vol.21 , pp. 96-103
    • Copeland, J.1    Swift, W.2
  • 31
    • 0034838977 scopus 로고    scopus 로고
    • A randomized controlled trial of brief cognitive-behavioral interventions for cannabis use disorder
    • Copeland J., Swift W., Roffman R., Stephens R. A randomized controlled trial of brief cognitive-behavioral interventions for cannabis use disorder. J Subst Abuse Treat 2001, 21:55-64.
    • (2001) J Subst Abuse Treat , vol.21 , pp. 55-64
    • Copeland, J.1    Swift, W.2    Roffman, R.3    Stephens, R.4
  • 32
    • 0034881260 scopus 로고    scopus 로고
    • Association study of cannabinoid receptor gene (CNR1) alleles and drug dependence
    • Covault J., Gelernter J., Kranzler H. Association study of cannabinoid receptor gene (CNR1) alleles and drug dependence. Mol Psychiatry 2001, 6:501-502.
    • (2001) Mol Psychiatry , vol.6 , pp. 501-502
    • Covault, J.1    Gelernter, J.2    Kranzler, H.3
  • 33
    • 0029904838 scopus 로고    scopus 로고
    • Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
    • Cravatt B.F., Giang D.K., Mayfield S.P., Boger D.L., Lerner R.A., Gilula N.B. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 1996, 384:83-87.
    • (1996) Nature , vol.384 , pp. 83-87
    • Cravatt, B.F.1    Giang, D.K.2    Mayfield, S.P.3    Boger, D.L.4    Lerner, R.A.5    Gilula, N.B.6
  • 34
    • 0035894872 scopus 로고    scopus 로고
    • Prevention of cannabinoid withdrawal syndrome by lithium: involvement of oxytocinergic neuronal activation
    • Cui S.S., Bowen R.C., Gu G.B., Hannesson D.K., Yu P.H., Zhang X. Prevention of cannabinoid withdrawal syndrome by lithium: involvement of oxytocinergic neuronal activation. J Neurosci 2001, 21:9867-9876.
    • (2001) J Neurosci , vol.21 , pp. 9867-9876
    • Cui, S.S.1    Bowen, R.C.2    Gu, G.B.3    Hannesson, D.K.4    Yu, P.H.5    Zhang, X.6
  • 36
    • 1242272173 scopus 로고    scopus 로고
    • Behavioral effects of cannabinoids show differential sensitivity to cannabinoid receptor blockade and tolerance development
    • De Vry J., Jentzch K.R., Kuhl E., Eckel G. Behavioral effects of cannabinoids show differential sensitivity to cannabinoid receptor blockade and tolerance development. Behav Pharmacol 2004, 15:1-12.
    • (2004) Behav Pharmacol , vol.15 , pp. 1-12
    • De Vry, J.1    Jentzch, K.R.2    Kuhl, E.3    Eckel, G.4
  • 37
    • 4043060858 scopus 로고    scopus 로고
    • Evidence for addiction-like behavior in the rat
    • Deroche-Gamonet V., Belin D., Piazza P.V. Evidence for addiction-like behavior in the rat. Science 2004, 305:951-953.
    • (2004) Science , vol.305 , pp. 951-953
    • Deroche-Gamonet, V.1    Belin, D.2    Piazza, P.V.3
  • 40
    • 77950660113 scopus 로고    scopus 로고
    • Endocannabinoids as regulators of transient receptor potential (TRP) channels: a further opportunity to develop new endocannabinoid-based therapeutic drugs
    • Di Marzo V., De Petrocellis L. Endocannabinoids as regulators of transient receptor potential (TRP) channels: a further opportunity to develop new endocannabinoid-based therapeutic drugs. Curr Med Chem 2010, 17:1430-1449.
    • (2010) Curr Med Chem , vol.17 , pp. 1430-1449
    • Di Marzo, V.1    De Petrocellis, L.2
  • 41
  • 42
    • 27844525479 scopus 로고    scopus 로고
    • Chemical constituents of marijuana: the complex mixture of natural cannabinoids
    • Elsohly M.A., Slade D. Chemical constituents of marijuana: the complex mixture of natural cannabinoids. Life Sci 2005, 78:539-548.
    • (2005) Life Sci , vol.78 , pp. 539-548
    • Elsohly, M.A.1    Slade, D.2
  • 44
    • 33749004496 scopus 로고    scopus 로고
    • Cannabinoid self-administration increases dopamine release in the nucleus accumbens
    • Fadda P., Scherma M., Spano M.S., Salis P., Melis V., Fattore L., Fratta W. Cannabinoid self-administration increases dopamine release in the nucleus accumbens. Neuroreport 2006, 17:1629-1632.
    • (2006) Neuroreport , vol.17 , pp. 1629-1632
    • Fadda, P.1    Scherma, M.2    Spano, M.S.3    Salis, P.4    Melis, V.5    Fattore, L.6    Fratta, W.7
  • 45
    • 0034941981 scopus 로고    scopus 로고
    • Intravenous self-administration of the cannabinoid CB1 receptor agonist WIN 55,212-2 in rats
    • Fattore L., Cossu G., Martellotta C.M., Fratta W. Intravenous self-administration of the cannabinoid CB1 receptor agonist WIN 55,212-2 in rats. Psychopharmacology (Berl) 2001, 156:410-416.
    • (2001) Psychopharmacology (Berl) , vol.156 , pp. 410-416
    • Fattore, L.1    Cossu, G.2    Martellotta, C.M.3    Fratta, W.4
  • 48
    • 35649027947 scopus 로고    scopus 로고
    • Cannabinoid self-administration in rats: sex differences and the influence of ovarian function
    • Fattore L., Spano M.S., Altea S., Angius F., Fadda P., Fratta W. Cannabinoid self-administration in rats: sex differences and the influence of ovarian function. Br J Pharmacol 2007, 152:795-804.
    • (2007) Br J Pharmacol , vol.152 , pp. 795-804
    • Fattore, L.1    Spano, M.S.2    Altea, S.3    Angius, F.4    Fadda, P.5    Fratta, W.6
  • 49
    • 77952601643 scopus 로고    scopus 로고
    • Drug- and cue-induced reinstatement of cannabinoid-seeking behaviour in male and female rats: influence of ovarian hormones
    • Fattore L., Spano M.S., Altea S., Fadda P., Fratta W. Drug- and cue-induced reinstatement of cannabinoid-seeking behaviour in male and female rats: influence of ovarian hormones. Br J Pharmacol 2010, 160:724-735.
    • (2010) Br J Pharmacol , vol.160 , pp. 724-735
    • Fattore, L.1    Spano, M.S.2    Altea, S.3    Fadda, P.4    Fratta, W.5
  • 50
    • 34147210041 scopus 로고    scopus 로고
    • Bidirectional regulation of mu-opioid and CB1-cannabinoid receptor in rats self-administering heroin or WIN 55,212-2
    • Fattore L., Vigano D., Fadda P., Rubino T., Fratta W., Parolaro D. Bidirectional regulation of mu-opioid and CB1-cannabinoid receptor in rats self-administering heroin or WIN 55,212-2. Eur J Neurosci 2007, 25:2191-2200.
    • (2007) Eur J Neurosci , vol.25 , pp. 2191-2200
    • Fattore, L.1    Vigano, D.2    Fadda, P.3    Rubino, T.4    Fratta, W.5    Parolaro, D.6
  • 51
    • 15744385109 scopus 로고    scopus 로고
    • Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation
    • Fegley D., Gaetani S., Duranti A., Tontini A., Mor M., Tarzia G., Piomelli D. Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. J Pharmacol Exp Ther 2005, 313:352-358.
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 352-358
    • Fegley, D.1    Gaetani, S.2    Duranti, A.3    Tontini, A.4    Mor, M.5    Tarzia, G.6    Piomelli, D.7
  • 53
    • 0034894593 scopus 로고    scopus 로고
    • The cannabinoid receptor agonist WIN 55,212-2 regulates glutamate transmission in rat cerebral cortex: an in vivo and in vitro study
    • Ferraro L., Tomasini M.C., Gessa G.L., Bebe B.W., Tanganelli S., Antonelli T. The cannabinoid receptor agonist WIN 55,212-2 regulates glutamate transmission in rat cerebral cortex: an in vivo and in vitro study. Cereb Cortex 2001, 11:728-733.
    • (2001) Cereb Cortex , vol.11 , pp. 728-733
    • Ferraro, L.1    Tomasini, M.C.2    Gessa, G.L.3    Bebe, B.W.4    Tanganelli, S.5    Antonelli, T.6
  • 54
    • 0035080215 scopus 로고    scopus 로고
    • Violent behavior as related to use of marijuana and other drugs
    • Friedman A.S., Glassman K., Terras B.A. Violent behavior as related to use of marijuana and other drugs. J Addict Dis 2001, 20:49-72.
    • (2001) J Addict Dis , vol.20 , pp. 49-72
    • Friedman, A.S.1    Glassman, K.2    Terras, B.A.3
  • 55
    • 33947489961 scopus 로고
    • Isolation, structure and partial synthesis of an active constituent of hashish
    • Gaoni Y., Mechoulam R. Isolation, structure and partial synthesis of an active constituent of hashish. J Am Chem Soc 1964, 86:1646-1647.
    • (1964) J Am Chem Soc , vol.86 , pp. 1646-1647
    • Gaoni, Y.1    Mechoulam, R.2
  • 56
    • 77952163415 scopus 로고    scopus 로고
    • Overexpression of CB2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice
    • García-Gutiérrez M.A., Manzanares J. Overexpression of CB2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice. J Psychopharmacol 2010, 24:757-765.
    • (2010) J Psychopharmacol , vol.24 , pp. 757-765
    • García-Gutiérrez, M.A.1    Manzanares, J.2
  • 59
    • 0030568611 scopus 로고    scopus 로고
    • 123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors
    • Gatley S.J., Gifford A.N., Volkow N.D., Lan R., Makriyannis A. 123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors. Eur J Pharmacol 1996, 307:331-338.
    • (1996) Eur J Pharmacol , vol.307 , pp. 331-338
    • Gatley, S.J.1    Gifford, A.N.2    Volkow, N.D.3    Lan, R.4    Makriyannis, A.5
  • 60
    • 0032472382 scopus 로고    scopus 로고
    • Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors
    • Gessa G.L., Melis M., Muntoni A.L., Diana M. Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors. Eur J Pharmacol 1998, 341:39-44.
    • (1998) Eur J Pharmacol , vol.341 , pp. 39-44
    • Gessa, G.L.1    Melis, M.2    Muntoni, A.L.3    Diana, M.4
  • 61
    • 0036470141 scopus 로고    scopus 로고
    • Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors
    • Ghozland S., Matthes H.W., Simonin F., Filliol D., Kieffer B.L., Maldonado R. Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors. J Neurosci 2002, 22:1146-1154.
    • (2002) J Neurosci , vol.22 , pp. 1146-1154
    • Ghozland, S.1    Matthes, H.W.2    Simonin, F.3    Filliol, D.4    Kieffer, B.L.5    Maldonado, R.6
  • 62
    • 0030857066 scopus 로고    scopus 로고
    • Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor
    • Glass M., Felder C.C. Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: evidence for a Gs linkage to the CB1 receptor. J Neurosci 1997, 17:5327-5333.
    • (1997) J Neurosci , vol.17 , pp. 5327-5333
    • Glass, M.1    Felder, C.C.2
  • 63
    • 77953512336 scopus 로고    scopus 로고
    • Afferent-specific AMPA receptor subunit composition and regulation of synaptic plasticity in midbrain dopamine neurons by abused drugs
    • Good C.H., Lupica C.R. Afferent-specific AMPA receptor subunit composition and regulation of synaptic plasticity in midbrain dopamine neurons by abused drugs. J Neurosci 2010, 30:7900-7909.
    • (2010) J Neurosci , vol.30 , pp. 7900-7909
    • Good, C.H.1    Lupica, C.R.2
  • 64
    • 0016135877 scopus 로고
    • The effect of delta1-tetrahydrocannabinol on the release of 3H-(-)-noradrenaline from the isolated vas deferens of the rat
    • Graham J.D., Lewis M.J., Li D.M. The effect of delta1-tetrahydrocannabinol on the release of 3H-(-)-noradrenaline from the isolated vas deferens of the rat. Br J Pharmacol 1974, 52:233-236.
    • (1974) Br J Pharmacol , vol.52 , pp. 233-236
    • Graham, J.D.1    Lewis, M.J.2    Li, D.M.3
  • 65
    • 0344685410 scopus 로고    scopus 로고
    • Being stoned: a review of self-reported cannabis effects
    • Green B., Kavanagh D., Young R. Being stoned: a review of self-reported cannabis effects. Drug Alcohol Rev 2003, 22:453-460.
    • (2003) Drug Alcohol Rev , vol.22 , pp. 453-460
    • Green, B.1    Kavanagh, D.2    Young, R.3
  • 66
    • 33644859608 scopus 로고    scopus 로고
    • Dissecting the causal anatomy of the link between cannabis and other illicit drugs
    • Hall W. Dissecting the causal anatomy of the link between cannabis and other illicit drugs. Addiction 2006, 101:472-473.
    • (2006) Addiction , vol.101 , pp. 472-473
    • Hall, W.1
  • 67
    • 70349859637 scopus 로고    scopus 로고
    • Adverse health effects of non-medical cannabis use
    • Hall W., Degenhardt L. Adverse health effects of non-medical cannabis use. Lancet 2009, 374:1383-1391.
    • (2009) Lancet , vol.374 , pp. 1383-1391
    • Hall, W.1    Degenhardt, L.2
  • 70
    • 26444480254 scopus 로고    scopus 로고
    • Increasing treatment options for cannabis dependence: a review of potential pharmacotherapies
    • Hart C.L. Increasing treatment options for cannabis dependence: a review of potential pharmacotherapies. Drug Alcohol Depend 2005, 80:147-159.
    • (2005) Drug Alcohol Depend , vol.80 , pp. 147-159
    • Hart, C.L.1
  • 72
    • 17744374252 scopus 로고    scopus 로고
    • The cannabinoid receptor gene (CNR1) is not affected in German i.v. drug users
    • Heller D., Schneider U., Seifert J., Cimander K.F., Stuhrmann M. The cannabinoid receptor gene (CNR1) is not affected in German i.v. drug users. Addict Biol 2001, 6:183-187.
    • (2001) Addict Biol , vol.6 , pp. 183-187
    • Heller, D.1    Schneider, U.2    Seifert, J.3    Cimander, K.F.4    Stuhrmann, M.5
  • 73
    • 11244260452 scopus 로고    scopus 로고
    • Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people
    • Henquet C., Krabbendam L., Spauwen J., Kaplan C., Lieb R., Wittchen H.U., van Os J. Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people. BMJ 2005, 330:11-16.
    • (2005) BMJ , vol.330 , pp. 11-16
    • Henquet, C.1    Krabbendam, L.2    Spauwen, J.3    Kaplan, C.4    Lieb, R.5    Wittchen, H.U.6    van Os, J.7
  • 74
    • 0025954862 scopus 로고
    • Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study
    • Herkenham M., Lynn A.B., Johnson M.R., Melvin L.S., de Costa B.R., Rice K.C. Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J Neurosci 1991, 11:563-583.
    • (1991) J Neurosci , vol.11 , pp. 563-583
    • Herkenham, M.1    Lynn, A.B.2    Johnson, M.R.3    Melvin, L.S.4    de Costa, B.R.5    Rice, K.C.6
  • 76
    • 0242583841 scopus 로고    scopus 로고
    • Serotonin and drug reward: focus on 5-HT2C receptors
    • Higgins G.A., Fletcher P.J. Serotonin and drug reward: focus on 5-HT2C receptors. Eur J Pharmacol 2003, 480:151-162.
    • (2003) Eur J Pharmacol , vol.480 , pp. 151-162
    • Higgins, G.A.1    Fletcher, P.J.2
  • 77
    • 0020059703 scopus 로고
    • Delta 9-tetrahydrocannabinol-induced changes in beta-adrenergic receptor binding in mouse cerebral cortex
    • Hillard C.J., Bloom A.S. Delta 9-tetrahydrocannabinol-induced changes in beta-adrenergic receptor binding in mouse cerebral cortex. Brain Res 1982, 235:370-377.
    • (1982) Brain Res , vol.235 , pp. 370-377
    • Hillard, C.J.1    Bloom, A.S.2
  • 78
    • 3343009510 scopus 로고    scopus 로고
    • A chemotaxonomic analysis of cannabinoid variation in Cannabis (Cannabaceae)
    • Hillig K.W., Mahlberg P.G. A chemotaxonomic analysis of cannabinoid variation in Cannabis (Cannabaceae). Am J Bot 2004, 91:966-975.
    • (2004) Am J Bot , vol.91 , pp. 966-975
    • Hillig, K.W.1    Mahlberg, P.G.2
  • 80
    • 33645796477 scopus 로고    scopus 로고
    • Cannabinoid receptor signaling
    • Howlett A.C. Cannabinoid receptor signaling. Handb Exp Pharmacol 2005, 168:53-79.
    • (2005) Handb Exp Pharmacol , vol.168 , pp. 53-79
    • Howlett, A.C.1
  • 82
    • 0031793070 scopus 로고    scopus 로고
    • Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with delta-9-tetrahydrocannabinol
    • Hutcheson D.M., Tzavara E.T., Smadja C., Valjent E., Roques B.P., Hanoune J., Maldonado R. Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with delta-9-tetrahydrocannabinol. Br J Pharmacol 1998, 125:1567-1577.
    • (1998) Br J Pharmacol , vol.125 , pp. 1567-1577
    • Hutcheson, D.M.1    Tzavara, E.T.2    Smadja, C.3    Valjent, E.4    Roques, B.P.5    Hanoune, J.6    Maldonado, R.7
  • 84
    • 33644817011 scopus 로고    scopus 로고
    • Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse
    • Ji S.P., Zhang Y., Van Cleemput J., Jiang W., Liao M., Li L., Wan Q., Backstrom J.R., Zhang X. Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse. Nat Med 2006, 12:324-329.
    • (2006) Nat Med , vol.12 , pp. 324-329
    • Ji, S.P.1    Zhang, Y.2    Van Cleemput, J.3    Jiang, W.4    Liao, M.5    Li, L.6    Wan, Q.7    Backstrom, J.R.8    Zhang, X.9
  • 88
    • 2342593865 scopus 로고    scopus 로고
    • The opioid antagonist naltrexone reduces the reinforcing effects of Delta 9 tetrahydrocannabinol (THC) in squirrel monkeys
    • Justinová Z., Tanda G., Munzar P., Goldberg S.R. The opioid antagonist naltrexone reduces the reinforcing effects of Delta 9 tetrahydrocannabinol (THC) in squirrel monkeys. Psychopharmacology (Berl) 2004, 173:186-194.
    • (2004) Psychopharmacology (Berl) , vol.173 , pp. 186-194
    • Justinová, Z.1    Tanda, G.2    Munzar, P.3    Goldberg, S.R.4
  • 89
    • 0141451976 scopus 로고    scopus 로고
    • Self-administration of delta9-tetrahydrocannabinol (THC) by drug naive squirrel monkeys
    • Justinová Z., Tanda G., Redhi G.H., Goldberg S.R. Self-administration of delta9-tetrahydrocannabinol (THC) by drug naive squirrel monkeys. Psychopharmacology 2003, 169:135-140.
    • (2003) Psychopharmacology , vol.169 , pp. 135-140
    • Justinová, Z.1    Tanda, G.2    Redhi, G.H.3    Goldberg, S.R.4
  • 93
    • 0017689682 scopus 로고
    • Naloxone-induced or postwithdrawal abstinence signs in delta9-tetrahydrocannabinol-tolerant rats
    • Kaymakcalan S., Ayhan I.H., Tulunay F.C. Naloxone-induced or postwithdrawal abstinence signs in delta9-tetrahydrocannabinol-tolerant rats. Psychopharmacology (Berl) 1977, 55:243-249.
    • (1977) Psychopharmacology (Berl) , vol.55 , pp. 243-249
    • Kaymakcalan, S.1    Ayhan, I.H.2    Tulunay, F.C.3
  • 94
    • 78650619344 scopus 로고    scopus 로고
    • Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay
    • Kinsey S.G., O'Neal S.T., Long J.Z., Cravatt B.F., Lichtman A.H. Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay. Pharmacol Biochem Behav 2011, 98:21-27.
    • (2011) Pharmacol Biochem Behav , vol.98 , pp. 21-27
    • Kinsey, S.G.1    O'Neal, S.T.2    Long, J.Z.3    Cravatt, B.F.4    Lichtman, A.H.5
  • 96
    • 33747608360 scopus 로고    scopus 로고
    • Monitoring extracellular dopamine in the rat nucleus accumbens shell and core during acquisition and maintenance of intravenous WIN 55,212-2 self-administration
    • Lecca D., Cacciapaglia F., Valentini V., Di Chiara G. Monitoring extracellular dopamine in the rat nucleus accumbens shell and core during acquisition and maintenance of intravenous WIN 55,212-2 self-administration. Psychopharmacology (Berl) 2006, 188:63-74.
    • (2006) Psychopharmacology (Berl) , vol.188 , pp. 63-74
    • Lecca, D.1    Cacciapaglia, F.2    Valentini, V.3    Di Chiara, G.4
  • 97
    • 0029997038 scopus 로고    scopus 로고
    • Genetic differences in delta9-tetrahydrocannabinol-induced facilitation of brain stimulation reward as measured by a rate-frequency curve-shift electrical brain stimulation paradigm in three different rat strains
    • Lepore M., Liu X., Savage V., Matalon D., Gardner E.L. Genetic differences in delta9-tetrahydrocannabinol-induced facilitation of brain stimulation reward as measured by a rate-frequency curve-shift electrical brain stimulation paradigm in three different rat strains. Life Sci 1996, 58:PL3654-PL3725.
    • (1996) Life Sci , vol.58
    • Lepore, M.1    Liu, X.2    Savage, V.3    Matalon, D.4    Gardner, E.L.5
  • 98
    • 0029036137 scopus 로고
    • Conditioned place preference induced by delta9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward
    • Lepore M., Vorel S.R., Lowinson J., Gardner E.L. Conditioned place preference induced by delta9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward. Life Sci 1995, 56:2073-2080.
    • (1995) Life Sci , vol.56 , pp. 2073-2080
    • Lepore, M.1    Vorel, S.R.2    Lowinson, J.3    Gardner, E.L.4
  • 99
    • 0034012612 scopus 로고    scopus 로고
    • No association between (AAT)n repeats in the cannabinoid receptor gene (CNR1) and heroin abuse in a Chinese population
    • Li T., Liu X., Zhu Z.H., Zhao J., Hu X., Ball D.M., Sham P.C., Collier D.A. No association between (AAT)n repeats in the cannabinoid receptor gene (CNR1) and heroin abuse in a Chinese population. Mol Psychiatry 2000, 5:128-130.
    • (2000) Mol Psychiatry , vol.5 , pp. 128-130
    • Li, T.1    Liu, X.2    Zhu, Z.H.3    Zhao, J.4    Hu, X.5    Ball, D.M.6    Sham, P.C.7    Collier, D.A.8
  • 100
    • 46649097590 scopus 로고    scopus 로고
    • Interactions between delta(9)-tetrahydrocannabinol and mu opioid receptor agonists in rhesus monkeys: discrimination and antinociception
    • Li J.X., McMahon L.R., Gerak L.R., Becker G.L., France C.P. Interactions between delta(9)-tetrahydrocannabinol and mu opioid receptor agonists in rhesus monkeys: discrimination and antinociception. Psychopharmacology (Berl) 2008, 199:199-208.
    • (2008) Psychopharmacology (Berl) , vol.199 , pp. 199-208
    • Li, J.X.1    McMahon, L.R.2    Gerak, L.R.3    Becker, G.L.4    France, C.P.5
  • 101
    • 0034979468 scopus 로고    scopus 로고
    • Precipitated cannabinoid withdrawal is reversed by delta(9)-tetrahydrocannabinol or clonidine
    • Lichtman A.H., Fisher J., Martin B.R. Precipitated cannabinoid withdrawal is reversed by delta(9)-tetrahydrocannabinol or clonidine. Pharmacol Biochem Behav 2001, 69:181-188.
    • (2001) Pharmacol Biochem Behav , vol.69 , pp. 181-188
    • Lichtman, A.H.1    Fisher, J.2    Martin, B.R.3
  • 102
    • 0034893982 scopus 로고    scopus 로고
    • Opioid and cannabinoid modulation of precipitated withdrawal in delta(9)-tetrahydrocannabinol and morphine-dependent mice
    • Lichtman A.H., Sheikh S.M., Loh H.H., Martin B.R. Opioid and cannabinoid modulation of precipitated withdrawal in delta(9)-tetrahydrocannabinol and morphine-dependent mice. J Pharmacol Exp Ther 2001, 298:1007-1014.
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 1007-1014
    • Lichtman, A.H.1    Sheikh, S.M.2    Loh, H.H.3    Martin, B.R.4
  • 103
    • 33645794039 scopus 로고    scopus 로고
    • Cannabinoid tolerance and dependence
    • Lichtman A.H., Martin B.R. Cannabinoid tolerance and dependence. Handb Exp Pharmacol 2005, 168:691-717.
    • (2005) Handb Exp Pharmacol , vol.168 , pp. 691-717
    • Lichtman, A.H.1    Martin, B.R.2
  • 104
    • 62449291740 scopus 로고    scopus 로고
    • Substitution profile of delta9-tetrahydrocannabinol, triazolam, hydromorphone, and methylphenidate in humans discriminating delta9-tetrahydrocannabinol
    • Lile J.A., Kelly T.H., Pinsky D.J., Hays L.R. Substitution profile of delta9-tetrahydrocannabinol, triazolam, hydromorphone, and methylphenidate in humans discriminating delta9-tetrahydrocannabinol. Psychopharmacology (Berl) 2009, 203:241-250.
    • (2009) Psychopharmacology (Berl) , vol.203 , pp. 241-250
    • Lile, J.A.1    Kelly, T.H.2    Pinsky, D.J.3    Hays, L.R.4
  • 106
    • 43749125007 scopus 로고    scopus 로고
    • The pharmacology of the endocannabinoid system: functional and structural interactions with other neurotransmitter systems and their repercussions in behavioral addiction
    • López-Moreno J.A., González-Cuevas G., Moreno G., Navarro M. The pharmacology of the endocannabinoid system: functional and structural interactions with other neurotransmitter systems and their repercussions in behavioral addiction. Addict Biol 2008, 13:160-187.
    • (2008) Addict Biol , vol.13 , pp. 160-187
    • López-Moreno, J.A.1    González-Cuevas, G.2    Moreno, G.3    Navarro, M.4
  • 107
    • 0038441717 scopus 로고    scopus 로고
    • A longitudinal study of the effects of adolescent cannabis use on high school completion
    • Lynskey M.T., Coffey C., Degenhardt L., Carlin J.B., Patton G. A longitudinal study of the effects of adolescent cannabis use on high school completion. Addiction 2003, 98:685-692.
    • (2003) Addiction , vol.98 , pp. 685-692
    • Lynskey, M.T.1    Coffey, C.2    Degenhardt, L.3    Carlin, J.B.4    Patton, G.5
  • 108
    • 2342443151 scopus 로고    scopus 로고
    • Psychological and social sequelae of cannabis and other illicit drug use by young people: a systematic review of longitudinal, general population studies
    • Macleod J., Oakes R., Copello A., Crome I., Egger M., Hickman M., Oppenkowski T., Stokes-Lampard H., Davey Smith G. Psychological and social sequelae of cannabis and other illicit drug use by young people: a systematic review of longitudinal, general population studies. Lancet 2004, 363:1579-1588.
    • (2004) Lancet , vol.363 , pp. 1579-1588
    • Macleod, J.1    Oakes, R.2    Copello, A.3    Crome, I.4    Egger, M.5    Hickman, M.6    Oppenkowski, T.7    Stokes-Lampard, H.8    Davey Smith, G.9
  • 109
    • 0036669501 scopus 로고    scopus 로고
    • Study of cannabinoid dependence in animals
    • Maldonado R. Study of cannabinoid dependence in animals. Pharmacol Ther 2002, 95:153-164.
    • (2002) Pharmacol Ther , vol.95 , pp. 153-164
    • Maldonado, R.1
  • 110
    • 33645982868 scopus 로고    scopus 로고
    • Involvement of the endocannabinoid system in drug addiction
    • Maldonado R., Valverde O., Berrendero F. Involvement of the endocannabinoid system in drug addiction. Trends Neurosci 2006, 29:225-232.
    • (2006) Trends Neurosci , vol.29 , pp. 225-232
    • Maldonado, R.1    Valverde, O.2    Berrendero, F.3
  • 111
    • 0031593783 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by delta 9-tetrahydrocannabinol or anandamide
    • Mallet P.E., Beninger R.J. The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by delta 9-tetrahydrocannabinol or anandamide. Psychopharmacology 1998, 140:11-19.
    • (1998) Psychopharmacology , vol.140 , pp. 11-19
    • Mallet, P.E.1    Beninger, R.J.2
  • 112
    • 2542499733 scopus 로고    scopus 로고
    • Brief treatments for cannabis dependence: findings from a randomized multisite trial
    • Marijuana Treatment Project Research Group
    • Brief treatments for cannabis dependence: findings from a randomized multisite trial. J Consult Clin Psychol 2004, 72:455-466. Marijuana Treatment Project Research Group.
    • (2004) J Consult Clin Psychol , vol.72 , pp. 455-466
  • 114
    • 0032495834 scopus 로고    scopus 로고
    • Self-administration of the cannabinoid receptor agonist WIN 55,212-2 in drug-naive mice
    • Martellotta M.C., Cossu G., Fattore L., Gessa G.L., Fratta W. Self-administration of the cannabinoid receptor agonist WIN 55,212-2 in drug-naive mice. Neuroscience 1998, 85:327-330.
    • (1998) Neuroscience , vol.85 , pp. 327-330
    • Martellotta, M.C.1    Cossu, G.2    Fattore, L.3    Gessa, G.L.4    Fratta, W.5
  • 115
    • 0027492734 scopus 로고
    • Localization of cannabinoid receptor mRNA in rat brain
    • Matsuda L.A., Bonner T.I., Lolait S.J. Localization of cannabinoid receptor mRNA in rat brain. J Comp Neurol 1993, 327:535-550.
    • (1993) J Comp Neurol , vol.327 , pp. 535-550
    • Matsuda, L.A.1    Bonner, T.I.2    Lolait, S.J.3
  • 116
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda L.A., Lolait S.J., Brownstein M.J., Young A.C., Bonner T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 1990, 346:561-564.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 117
    • 0030005172 scopus 로고    scopus 로고
    • Aversive effects of the synthetic cannabinoid CP 55,940 in rats
    • McGregor I.S., Issackidis C., Prior G. Aversive effects of the synthetic cannabinoid CP 55,940 in rats. Pharmacol Biochem Behav 1996, 53:657-664.
    • (1996) Pharmacol Biochem Behav , vol.53 , pp. 657-664
    • McGregor, I.S.1    Issackidis, C.2    Prior, G.3
  • 118
    • 45149112738 scopus 로고    scopus 로고
    • Cannabis potency and contamination: a review of the literature
    • McLaren J., Swift W., Dillon P., Allsop S. Cannabis potency and contamination: a review of the literature. Addiction 2008, 103:1100-1109.
    • (2008) Addiction , vol.103 , pp. 1100-1109
    • McLaren, J.1    Swift, W.2    Dillon, P.3    Allsop, S.4
  • 121
    • 33747333091 scopus 로고    scopus 로고
    • Involvement of kappa/dynorphin system in WIN 55,212-2 self-administration in mice
    • Mendizabal V., Zimmer A., Maldonado R. Involvement of kappa/dynorphin system in WIN 55,212-2 self-administration in mice. Neuropsychopharmacology 2006, 31:1957-1966.
    • (2006) Neuropsychopharmacology , vol.31 , pp. 1957-1966
    • Mendizabal, V.1    Zimmer, A.2    Maldonado, R.3
  • 122
    • 0022530231 scopus 로고
    • The role of benzodiazepine receptors in the discriminative stimulus properties of delta-9-tetrahydrocannabinol
    • Mokler D.J., Nelson B.D., Harris L.S., Rosecrans J.A. The role of benzodiazepine receptors in the discriminative stimulus properties of delta-9-tetrahydrocannabinol. Life Sci 1986, 38:1581-1589.
    • (1986) Life Sci , vol.38 , pp. 1581-1589
    • Mokler, D.J.1    Nelson, B.D.2    Harris, L.S.3    Rosecrans, J.A.4
  • 125
    • 59449084379 scopus 로고    scopus 로고
    • Chronic treatment and withdrawal of the cannabinoid agonist WIN 55,212-2 modulate the sensitivity of presynaptic receptors involved in the regulation of monoamine syntheses in rat brain
    • Moranta D., Esteban S., García-Sevilla J.A. Chronic treatment and withdrawal of the cannabinoid agonist WIN 55,212-2 modulate the sensitivity of presynaptic receptors involved in the regulation of monoamine syntheses in rat brain. Naunyn Schmiedebergs Arch Pharmacol 2009, 379:61-72.
    • (2009) Naunyn Schmiedebergs Arch Pharmacol , vol.379 , pp. 61-72
    • Moranta, D.1    Esteban, S.2    García-Sevilla, J.A.3
  • 127
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro S., Thomas K.L., Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993, 365:61-65.
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 131
    • 34548512479 scopus 로고    scopus 로고
    • Biosynthetic pathways of the endocannabinoid anandamide
    • Okamoto Y., Wang J., Morishita J., Ueda N. Biosynthetic pathways of the endocannabinoid anandamide. Chem Biodivers 2007, 4:1842-1857.
    • (2007) Chem Biodivers , vol.4 , pp. 1842-1857
    • Okamoto, Y.1    Wang, J.2    Morishita, J.3    Ueda, N.4
  • 132
    • 33645367848 scopus 로고
    • Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain
    • Olds J., Milner P. Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. J Comp Physiol Psychol 1954, 47:419-427.
    • (1954) J Comp Physiol Psychol , vol.47 , pp. 419-427
    • Olds, J.1    Milner, P.2
  • 133
    • 38049026711 scopus 로고    scopus 로고
    • Local administration of a cannabinoid agonist alters norepinephrine efflux in the rat frontal cortex
    • Page M.E., Oropeza V.C., Van Bockstaele E.J. Local administration of a cannabinoid agonist alters norepinephrine efflux in the rat frontal cortex. Neurosci Lett 2008, 431:1-5.
    • (2008) Neurosci Lett , vol.431 , pp. 1-5
    • Page, M.E.1    Oropeza, V.C.2    Van Bockstaele, E.J.3
  • 135
    • 0028874194 scopus 로고
    • THC-induced place and taste aversions in Lewis and Sprague-Dawley rats
    • Parker L.A., Gillies T. THC-induced place and taste aversions in Lewis and Sprague-Dawley rats. Behav Neurosci 1995, 109:71-78.
    • (1995) Behav Neurosci , vol.109 , pp. 71-78
    • Parker, L.A.1    Gillies, T.2
  • 137
    • 84884474728 scopus 로고    scopus 로고
    • Pharmacological actions of cannabinoids
    • Pertwee R.G. Pharmacological actions of cannabinoids. Handb Exp Pharmacol 2005, 168:1-51.
    • (2005) Handb Exp Pharmacol , vol.168 , pp. 1-51
    • Pertwee, R.G.1
  • 139
    • 22144447474 scopus 로고    scopus 로고
    • Strong increase in total delta-THC in cannabis preparations sold in Dutch coffee shops
    • Pijlman F.T., Rigter S.M., Hoek J., Goldschmidt H.M., Niesink R.J. Strong increase in total delta-THC in cannabis preparations sold in Dutch coffee shops. Addict Biol 2005, 10:171-180.
    • (2005) Addict Biol , vol.10 , pp. 171-180
    • Pijlman, F.T.1    Rigter, S.M.2    Hoek, J.3    Goldschmidt, H.M.4    Niesink, R.J.5
  • 148
    • 33947528392 scopus 로고    scopus 로고
    • An NMDA antagonist (LY 235959) attenuates abstinence-induced withdrawal of planarians following acute exposure to a cannabinoid agonist (WIN 55212-2)
    • Rawls S.M., Gomez T., Raffa R.B. An NMDA antagonist (LY 235959) attenuates abstinence-induced withdrawal of planarians following acute exposure to a cannabinoid agonist (WIN 55212-2). Pharmacol Biochem Behav 2007, 86:499-504.
    • (2007) Pharmacol Biochem Behav , vol.86 , pp. 499-504
    • Rawls, S.M.1    Gomez, T.2    Raffa, R.B.3
  • 151
    • 33745085564 scopus 로고    scopus 로고
    • Mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis
    • Rios C., Gomes I., Devi L.A. mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis. Br J Pharmacol 2006, 148:387-395.
    • (2006) Br J Pharmacol , vol.148 , pp. 387-395
    • Rios, C.1    Gomes, I.2    Devi, L.A.3
  • 152
    • 0027954332 scopus 로고
    • Cannabinoid receptors in rat brain areas: sexual differences, fluctuations during estrous cycle and changes after gonadectomy and sex steroid replacement
    • Rodríguez de Fonseca F., Cebeira M., Ramos J.A., Martín M., Fernández-Ruiz J.J. Cannabinoid receptors in rat brain areas: sexual differences, fluctuations during estrous cycle and changes after gonadectomy and sex steroid replacement. Life Sci 1994, 54:159-170.
    • (1994) Life Sci , vol.54 , pp. 159-170
    • Rodríguez de Fonseca, F.1    Cebeira, M.2    Ramos, J.A.3    Martín, M.4    Fernández-Ruiz, J.J.5
  • 153
    • 0039534405 scopus 로고    scopus 로고
    • Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal
    • Rodríguez de Fonseca F., Carrera M.R., Navarro M., Koob G.F., Weiss F. Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal. Science 1997, 276:2050-2054.
    • (1997) Science , vol.276 , pp. 2050-2054
    • Rodríguez de Fonseca, F.1    Carrera, M.R.2    Navarro, M.3    Koob, G.F.4    Weiss, F.5
  • 154
    • 0035112869 scopus 로고    scopus 로고
    • Ultrastructural localization of the CB1 cannabinoid receptor in mu opioid receptor patches of the rat caudate putamen nucleus
    • Rodríguez J.J., Mackie K., Pickel V.M. Ultrastructural localization of the CB1 cannabinoid receptor in mu opioid receptor patches of the rat caudate putamen nucleus. J Neurosci 2001, 21:823-833.
    • (2001) J Neurosci , vol.21 , pp. 823-833
    • Rodríguez, J.J.1    Mackie, K.2    Pickel, V.M.3
  • 155
  • 156
    • 0031987342 scopus 로고    scopus 로고
    • Antisense oligodeoxynucleotides to the kappa1 receptor enhance delta9-THC-induced antinociceptive tolerance
    • Rowen D.W., Embrey J.P., Moore C.H., Welch S.P. Antisense oligodeoxynucleotides to the kappa1 receptor enhance delta9-THC-induced antinociceptive tolerance. Pharmacol Biochem Behav 1998, 59:399-404.
    • (1998) Pharmacol Biochem Behav , vol.59 , pp. 399-404
    • Rowen, D.W.1    Embrey, J.P.2    Moore, C.H.3    Welch, S.P.4
  • 158
    • 0035807990 scopus 로고    scopus 로고
    • CB1-cannabinoid and mu opioid receptor co-localization on postsynaptic target in the rat dorsal horn
    • Salio C., Fischer J., Franzoni M.F., Mackie K., Kaneko T., Conrath M. CB1-cannabinoid and mu opioid receptor co-localization on postsynaptic target in the rat dorsal horn. Neuroreport 2001, 12:3689-3692.
    • (2001) Neuroreport , vol.12 , pp. 3689-3692
    • Salio, C.1    Fischer, J.2    Franzoni, M.F.3    Mackie, K.4    Kaneko, T.5    Conrath, M.6
  • 159
    • 70449406726 scopus 로고    scopus 로고
    • SAMHSA, Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, Substance Abuse and Mental Health Services Administration, Office of Applied Studies, North Carolina
    • Results from the 2008 National Survey on Drug Use and Health: National Findings 2008, SAMHSA, Substance Abuse and Mental Health Services Administration, U.S. Department of Health and Human Services, Substance Abuse and Mental Health Services Administration, Office of Applied Studies, North Carolina.
    • (2008) Results from the 2008 National Survey on Drug Use and Health: National Findings
  • 160
    • 77957904093 scopus 로고    scopus 로고
    • SAMHSA, Substance Abuse and Mental Health Services Administration, (Office of Applied Studies, NSDUH Series H-38A, HHS Publication No. SMA 10-4856Findings), Rockville, MD
    • Results from the 2009 National Survey on Drug Use and Health: Volume I. Summary of National Findings 2010, SAMHSA, Substance Abuse and Mental Health Services Administration, (Office of Applied Studies, NSDUH Series H-38A, HHS Publication No. SMA 10-4856Findings), Rockville, MD.
    • (2010) Results from the 2009 National Survey on Drug Use and Health: Volume I. Summary of National Findings
  • 161
    • 33750686609 scopus 로고    scopus 로고
    • Behavioural assessment of drug reinforcement and addictive features in rodents: an overview
    • Sanchis-Segura C., Spanagel R. Behavioural assessment of drug reinforcement and addictive features in rodents: an overview. Addict Biol 2006, 11:2-38.
    • (2006) Addict Biol , vol.11 , pp. 2-38
    • Sanchis-Segura, C.1    Spanagel, R.2
  • 166
    • 33748160553 scopus 로고    scopus 로고
    • Interactions between CB1 cannabinoid and mu opioid receptors mediating inhibition of neurotransmitter release in rat nucleus accumbens core
    • Schoffelmeer A.N., Hogenboom F., Wardeh G., De Vries T.J. Interactions between CB1 cannabinoid and mu opioid receptors mediating inhibition of neurotransmitter release in rat nucleus accumbens core. Neuropharmacology 2006, 51:773-781.
    • (2006) Neuropharmacology , vol.51 , pp. 773-781
    • Schoffelmeer, A.N.1    Hogenboom, F.2    Wardeh, G.3    De Vries, T.J.4
  • 167
    • 0028261433 scopus 로고
    • Interactions between delta 9-tetrahydrocannabinol and kappa opioids in mice
    • Smith P.B., Welch S.P., Martin B.R. Interactions between delta 9-tetrahydrocannabinol and kappa opioids in mice. J Pharmacol Exp Ther 1994, 268:1381-1387.
    • (1994) J Pharmacol Exp Ther , vol.268 , pp. 1381-1387
    • Smith, P.B.1    Welch, S.P.2    Martin, B.R.3
  • 168
    • 20044396210 scopus 로고    scopus 로고
    • Involvement of mu-, delta- and kappa-opioid receptor subtypes in the discriminative-stimulus effects of delta-9-tetrahydrocannabinol (THC) in rats
    • Solinas M., Goldberg S.R. Involvement of mu-, delta- and kappa-opioid receptor subtypes in the discriminative-stimulus effects of delta-9-tetrahydrocannabinol (THC) in rats. Psychopharmacol (Berl) 2005, 179:804-812.
    • (2005) Psychopharmacol (Berl) , vol.179 , pp. 804-812
    • Solinas, M.1    Goldberg, S.R.2
  • 169
    • 33746541662 scopus 로고    scopus 로고
    • Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats
    • Solinas M., Justinová Z., Goldberg S.R., Tanda G. Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats. J Neurochem 2006, 98:408-419.
    • (2006) J Neurochem , vol.98 , pp. 408-419
    • Solinas, M.1    Justinová, Z.2    Goldberg, S.R.3    Tanda, G.4
  • 171
    • 34248572522 scopus 로고    scopus 로고
    • Nicotinic facilitation of delta9-tetrahydrocannabinol discrimination involves endogenous anandamide
    • Solinas M., Scherma M., Tanda G., Wertheim C.E., Fratta W., Goldberg S.R. Nicotinic facilitation of delta9-tetrahydrocannabinol discrimination involves endogenous anandamide. J Pharmacol Exp Ther 2007, 321:1127-1134.
    • (2007) J Pharmacol Exp Ther , vol.321 , pp. 1127-1134
    • Solinas, M.1    Scherma, M.2    Tanda, G.3    Wertheim, C.E.4    Fratta, W.5    Goldberg, S.R.6
  • 172
    • 77952767966 scopus 로고    scopus 로고
    • Dopaminergic augmentation of delta-9-tetrahydrocannabinol (THC) discrimination: possible involvement of d(2)-induced formation of anandamide
    • Solinas M., Tanda G., Wertheim C.E., Goldberg S.R. Dopaminergic augmentation of delta-9-tetrahydrocannabinol (THC) discrimination: possible involvement of d(2)-induced formation of anandamide. Psychopharmacology (Berl) 2010, 209:191-202.
    • (2010) Psychopharmacology (Berl) , vol.209 , pp. 191-202
    • Solinas, M.1    Tanda, G.2    Wertheim, C.E.3    Goldberg, S.R.4
  • 173
    • 3042709603 scopus 로고    scopus 로고
    • Beta-endorphin elevations in the ventral tegmental area regulate the discriminative effects of delta-9-tetrahydrocannabinol
    • Solinas M., Zangen A., Thiriet N., Goldberg S.R. Beta-endorphin elevations in the ventral tegmental area regulate the discriminative effects of delta-9-tetrahydrocannabinol. Eur J Neurosci 2004, 19:3183-3192.
    • (2004) Eur J Neurosci , vol.19 , pp. 3183-3192
    • Solinas, M.1    Zangen, A.2    Thiriet, N.3    Goldberg, S.R.4
  • 175
    • 7044234515 scopus 로고    scopus 로고
    • CB1 receptor agonist and heroin, but not cocaine, reinstate cannabinoid-seeking behaviour in the rat
    • Spano M.S., Fattore L., Cossu G., Deiana S., Fadda P., Fratta W. CB1 receptor agonist and heroin, but not cocaine, reinstate cannabinoid-seeking behaviour in the rat. Br J Pharmacol 2004, 143:343-350.
    • (2004) Br J Pharmacol , vol.143 , pp. 343-350
    • Spano, M.S.1    Fattore, L.2    Cossu, G.3    Deiana, S.4    Fadda, P.5    Fratta, W.6
  • 176
    • 77953216492 scopus 로고    scopus 로고
    • Altered architecture and functional consequences of the mesolimbic dopamine system in cannabis dependence
    • Spiga S., Lintas A., Migliore M., Diana M. Altered architecture and functional consequences of the mesolimbic dopamine system in cannabis dependence. Addict Biol 2010, 15:266-276.
    • (2010) Addict Biol , vol.15 , pp. 266-276
    • Spiga, S.1    Lintas, A.2    Migliore, M.3    Diana, M.4
  • 177
    • 77954406421 scopus 로고    scopus 로고
    • Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas
    • Stella N. Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas. Glia 2010, 58:1017-1030.
    • (2010) Glia , vol.58 , pp. 1017-1030
    • Stella, N.1
  • 178
    • 77953772802 scopus 로고    scopus 로고
    • Rimonabant-induced delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs
    • Stewart J.L., McMahon L.R. Rimonabant-induced delta9-tetrahydrocannabinol withdrawal in rhesus monkeys: discriminative stimulus effects and other withdrawal signs. J Pharmacol Exp Ther 2010, 334:347-356.
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 347-356
    • Stewart, J.L.1    McMahon, L.R.2
  • 179
    • 73149104901 scopus 로고    scopus 로고
    • Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons
    • Straiker A., Hu S.S., Long J.Z., Arnold A., Wager-Miller J., Cravatt B.F., Mackie K. Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons. Mol Pharmacol 2009, 76:1220-1227.
    • (2009) Mol Pharmacol , vol.76 , pp. 1220-1227
    • Straiker, A.1    Hu, S.S.2    Long, J.Z.3    Arnold, A.4    Wager-Miller, J.5    Cravatt, B.F.6    Mackie, K.7
  • 180
    • 33745195042 scopus 로고    scopus 로고
    • Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand
    • Sugiura T., Kishimoto S., Oka S., Gokoh M. Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand. Prog Lipid Res 2006, 45:405-446.
    • (2006) Prog Lipid Res , vol.45 , pp. 405-446
    • Sugiura, T.1    Kishimoto, S.2    Oka, S.3    Gokoh, M.4
  • 181
    • 0036019386 scopus 로고    scopus 로고
    • Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance
    • Sugiura T., Kobayashi Y., Oka S., Waku K. Biosynthesis and degradation of anandamide and 2-arachidonoylglycerol and their possible physiological significance. Prostaglandins Leukot Essent Fatty Acids 2002, 66:173-192.
    • (2002) Prostaglandins Leukot Essent Fatty Acids , vol.66 , pp. 173-192
    • Sugiura, T.1    Kobayashi, Y.2    Oka, S.3    Waku, K.4
  • 183
    • 18844419446 scopus 로고    scopus 로고
    • Effects of cannabinoids on neurotransmission
    • Szabo B., Schlicker E. Effects of cannabinoids on neurotransmission. Handb Exp Pharmacol 2005, 168:327-365.
    • (2005) Handb Exp Pharmacol , vol.168 , pp. 327-365
    • Szabo, B.1    Schlicker, E.2
  • 184
    • 0032988722 scopus 로고    scopus 로고
    • Dependence of mesolimbic dopamine transmission on delta9-tetrahydrocannabinol
    • Tanda G., Loddo P., Di Chiara G. Dependence of mesolimbic dopamine transmission on delta9-tetrahydrocannabinol. Eur J Pharmacol 1999, 376:23-26.
    • (1999) Eur J Pharmacol , vol.376 , pp. 23-26
    • Tanda, G.1    Loddo, P.2    Di Chiara, G.3
  • 185
    • 0033773866 scopus 로고    scopus 로고
    • Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys
    • Tanda G., Munzar P., Goldberg S.R. Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys. Nat Neurosci 2000, 3:1073-1074.
    • (2000) Nat Neurosci , vol.3 , pp. 1073-1074
    • Tanda, G.1    Munzar, P.2    Goldberg, S.R.3
  • 186
    • 0030761521 scopus 로고    scopus 로고
    • Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism
    • Tanda G., Pontieri F.E., Di Chiara G. Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism. Science 1997, 276:2048-2050.
    • (1997) Science , vol.276 , pp. 2048-2050
    • Tanda, G.1    Pontieri, F.E.2    Di Chiara, G.3
  • 188
    • 0028278083 scopus 로고
    • Evidence for a bidirectional cross-tolerance between morphine and delta 9-tetrahydrocannabinol in mice
    • Thorat S.N., Bhargava H.N. Evidence for a bidirectional cross-tolerance between morphine and delta 9-tetrahydrocannabinol in mice. Eur J Pharmacol 1994, 260:5-13.
    • (1994) Eur J Pharmacol , vol.260 , pp. 5-13
    • Thorat, S.N.1    Bhargava, H.N.2
  • 189
    • 67651175892 scopus 로고    scopus 로고
    • Anandamide and the vanilloid receptor (TRPV1)
    • Tóth A., Blumberg P.M., Boczán J. Anandamide and the vanilloid receptor (TRPV1). Vitam Horm 2009, 81:389-419.
    • (2009) Vitam Horm , vol.81 , pp. 389-419
    • Tóth, A.1    Blumberg, P.M.2    Boczán, J.3
  • 191
    • 0019308268 scopus 로고
    • Constituents of Cannabis sativa L. XVII. A review of the natural constituents
    • Turner C.E., Elsohly M.A., Boeren E.G. Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod 1980, 43:169-234.
    • (1980) J Nat Prod , vol.43 , pp. 169-234
    • Turner, C.E.1    Elsohly, M.A.2    Boeren, E.G.3
  • 192
    • 0033972058 scopus 로고    scopus 로고
    • A behavioural model to reveal place preference to delta 9-tetrahydrocannabinol in mice
    • Valjent E., Maldonado R. A behavioural model to reveal place preference to delta 9-tetrahydrocannabinol in mice. Psychopharmacology 2000, 147:436-438.
    • (2000) Psychopharmacology , vol.147 , pp. 436-438
    • Valjent, E.1    Maldonado, R.2
  • 193
    • 0034671190 scopus 로고    scopus 로고
    • Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice
    • Valverde O., Maldonado R., Valjent E., Zimmer A.M., Zimmer A. Cannabinoid withdrawal syndrome is reduced in pre-proenkephalin knock-out mice. J Neurosci 2000, 20:9284-9289.
    • (2000) J Neurosci , vol.20 , pp. 9284-9289
    • Valverde, O.1    Maldonado, R.2    Valjent, E.3    Zimmer, A.M.4    Zimmer, A.5
  • 195
    • 32244443056 scopus 로고    scopus 로고
    • Drug seeking becomes compulsive after prolonged cocaine self-administration
    • Vanderschuren L.J., Everitt B.J. Drug seeking becomes compulsive after prolonged cocaine self-administration. Science 2004, 13:951-953.
    • (2004) Science , vol.13 , pp. 951-953
    • Vanderschuren, L.J.1    Everitt, B.J.2
  • 196
    • 33645795765 scopus 로고    scopus 로고
    • Retrograde signalling by endocannabinoids
    • Vaughan C.W., Christie M.J. Retrograde signalling by endocannabinoids. Handb Exp Pharmacol 2005, 168:367-383.
    • (2005) Handb Exp Pharmacol , vol.168 , pp. 367-383
    • Vaughan, C.W.1    Christie, M.J.2
  • 199
    • 33745025055 scopus 로고    scopus 로고
    • Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis
    • Wade D.T., Makela P.M., House H., Bateman C., Robson P. Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis. Mult Scler 2006, 12:639-645.
    • (2006) Mult Scler , vol.12 , pp. 639-645
    • Wade, D.T.1    Makela, P.M.2    House, H.3    Bateman, C.4    Robson, P.5
  • 200
    • 77953796878 scopus 로고    scopus 로고
    • Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis
    • Wade D.T., Collin C., Scott C., Duncombe P. Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis. Mult Scler 2010, 16:707-714.
    • (2010) Mult Scler , vol.16 , pp. 707-714
    • Wade, D.T.1    Collin, C.2    Scott, C.3    Duncombe, P.4
  • 201
    • 0036199639 scopus 로고    scopus 로고
    • From first drug use to drug dependence; developmental periods of risk for dependence upon marijuana, cocaine, and alcohol
    • Wagner F.A., Anthony J.C. From first drug use to drug dependence; developmental periods of risk for dependence upon marijuana, cocaine, and alcohol. Neuropsychopharmacology 2002, 26:479-488.
    • (2002) Neuropsychopharmacology , vol.26 , pp. 479-488
    • Wagner, F.A.1    Anthony, J.C.2
  • 202
    • 76249132039 scopus 로고    scopus 로고
    • The abuse potential of the synthetic cannabinoid nabilone
    • Ware M.A., St.Arnaud-Trempe E. The abuse potential of the synthetic cannabinoid nabilone. Addiction 2010, 105:494-503.
    • (2010) Addiction , vol.105 , pp. 494-503
    • Ware, M.A.1    St.Arnaud-Trempe, E.2
  • 203
    • 0030975023 scopus 로고    scopus 로고
    • Characterization of anandamide-induced tolerance: comparison to delta 9-THC-induced interactions with dynorphinergic systems
    • Welch S.P. Characterization of anandamide-induced tolerance: comparison to delta 9-THC-induced interactions with dynorphinergic systems. Drug Alcohol Depend 1997, 45:39-45.
    • (1997) Drug Alcohol Depend , vol.45 , pp. 39-45
    • Welch, S.P.1
  • 204
    • 0032847529 scopus 로고    scopus 로고
    • Effects of SR141716A on diazepam substitution for delta9-tetrahydrocannabinol in rat drug discrimination
    • Wiley J.L., Martin B.R. Effects of SR141716A on diazepam substitution for delta9-tetrahydrocannabinol in rat drug discrimination. Pharmacol Biochem Behav 1999, 64:519-522.
    • (1999) Pharmacol Biochem Behav , vol.64 , pp. 519-522
    • Wiley, J.L.1    Martin, B.R.2
  • 205
    • 53949126141 scopus 로고    scopus 로고
    • Repeated cannabinoid injections into the rat periaqueductal gray enhance subsequent morphine antinociception
    • Wilson A.R., Maher L., Morgan M.M. Repeated cannabinoid injections into the rat periaqueductal gray enhance subsequent morphine antinociception. Neuropharmacology 2008, 55:1219-1225.
    • (2008) Neuropharmacology , vol.55 , pp. 1219-1225
    • Wilson, A.R.1    Maher, L.2    Morgan, M.M.3
  • 206
    • 0035967145 scopus 로고    scopus 로고
    • Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
    • Wilson R.I., Nicoll R.A. Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. Nature 2001, 410:588-592.
    • (2001) Nature , vol.410 , pp. 588-592
    • Wilson, R.I.1    Nicoll, R.A.2
  • 207
    • 0037177601 scopus 로고    scopus 로고
    • Endocannabinoid signaling in the brain
    • Wilson R.I., Nicoll R.A. Endocannabinoid signaling in the brain. Science 2002, 296:678-682.
    • (2002) Science , vol.296 , pp. 678-682
    • Wilson, R.I.1    Nicoll, R.A.2
  • 208
    • 43449130829 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor antagonists attenuate concaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats
    • Xi Z.X., Spiller K., Pak A.C., Gilbert J., Dillon C., Li X., et al. Cannabinoid CB1 receptor antagonists attenuate concaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. Neuropsychopharmacology 2007, 33:1735-1745.
    • (2007) Neuropsychopharmacology , vol.33 , pp. 1735-1745
    • Xi, Z.X.1    Spiller, K.2    Pak, A.C.3    Gilbert, J.4    Dillon, C.5    Li, X.6
  • 209
    • 0019604854 scopus 로고
    • Behavioral effects of levonantradol and nantradol in the rhesus monkey
    • Young A.M., Katz J.L., Woods J.H. Behavioral effects of levonantradol and nantradol in the rhesus monkey. J Clin Pharmacol 1981, 21:348S-360S.
    • (1981) J Clin Pharmacol , vol.21
    • Young, A.M.1    Katz, J.L.2    Woods, J.H.3
  • 211
    • 6044253601 scopus 로고    scopus 로고
    • Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse
    • Zhang P.W., Ishiguro H., Ohtsuki T., Hess J., Carillo F., Walther D., Onaivi E.S., Arinami T., Uhl G.R. Human cannabinoid receptor 1: 5' exons, candidate regulatory regions, polymorphisms, haplotypes and association with polysubstance abuse. Mol Psychiatry 2004, 9:916-931.
    • (2004) Mol Psychiatry , vol.9 , pp. 916-931
    • Zhang, P.W.1    Ishiguro, H.2    Ohtsuki, T.3    Hess, J.4    Carillo, F.5    Walther, D.6    Onaivi, E.S.7    Arinami, T.8    Uhl, G.R.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.