Endocannabinoid signaling system and brain reward: Emphasis on dopamine

Pharmacology Biochemistry and Behavior

Volumn 81, Issue 2 SPEC. ISS., 2005, Pages 263-284

  Gardner, Eliot L ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Addiction; Cannabinoids; Dopamine; Endocannabinoids; Medial forebrain bundle; Nucleus accumbens; Reinforcement; Reward; Self administration; Self stimulation; Ventral tegmental area

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; DEXANABINOL; DOPAMINE; DRONABINOL; ENDOCANNABINOID; NALOXONE; OPIATE ANTAGONIST; RIMONABANT;

ADDICTION; ANIMAL BEHAVIOR; BRAIN DEPTH STIMULATION; BRAIN DYSFUNCTION; CONFERENCE PAPER; DOPAMINERGIC NERVE CELL; DRUG DEPENDENCE; DRUG SELF ADMINISTRATION; MEDIAL FOREBRAIN BUNDLE; MOTIVATION; NERVE CELL MEMBRANE POTENTIAL; NERVE CELL PLASTICITY; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; NUCLEUS ACCUMBENS; PLACE PREFERENCE; PRIORITY JOURNAL; REWARD; SIGNAL TRANSDUCTION; SYNAPSE; SYNAPTIC MEMBRANE; VENTRAL TEGMENTUM;

ANIMALIA;

EID: 20444398090     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2005.01.032     Document Type: Conference Paper

References (279)

1. M.D. Aceto, S.M. Scates, J.A. Lowe, and B.R. Martin Dependence on delta 9-tetrahydrocannabinol: studies on precipitated and abrupt withdrawal J Pharmacol Exp Ther 278 1996 1290 1295
2. M.D. Aceto, S.M. Scates, J.A. Lowe, and B.R. Martin Spontaneous and precipitated withdrawal from a synthetic cannabinoid, WIN 55,212-2 Eur J Pharmacol 416 2001 75 81
3. B.E. Alger Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids Prog Neurobiol 68 2002 247 286
4. Z. Amit, B.R. Smith, and E.A. Sutherland Oral self-administration of alcohol: a valid approach to the study of drug self-administration and human alcoholism M.A. Bozarth Methods of assessing the reinforcing properties of abused drugs 1987 Springer-Verlag New York 161 171
5. J.C. Anthony, L.A. Warner, and R.C. Kessler Comparative epidemiology of dependence on tobacco, alcohol, controlled substances and inhalants: basic findings from National Comorbidity Study Exp Clin Psychopharmacol 2 1994 244 268
6. B receptor in gamma vinyl-GABA's inhibition of cocaine-induced increases in nucleus accumbens dopamine Synapse 31 1999 151 153
7. S.P. Banerjee, S.H. Snyder, and R. Mechoulam Cannabinoids: influence on neurotransmitter uptake in rat brain synaptosomes J Pharmacol Exp Ther 194 1975 74 81
8. M.T. Bardo Neuropharmacological mechanisms of drug reward: beyond dopamine in the nucleus accumbens Crit Rev Neurobiol 12 1998 37 67
9. D. Beitner-Johnson, X. Guitart, and E.J. Nestler Dopaminergic brain reward regions of Lewis and Fischer rats display different levels of tyrosine hydroxylase and other morphine- and cocaine-regulated phosphoproteins Brain Res 561 1991 147 150
10. K.C. Berridge, and T.E. Robinson What is the role of dopamine in reward: hedonic impact, reward learning or incentive salience? Brain Res Rev 28 1998 309 369
11. M. Bidaut-Russell, W.A. Devane, and A.C. Howlett Cannabinoid receptors and activation of cyclic AMP accumulation in the brain J Neurochem 55 1990 21 26
12. D. Bindra Neuropsychological interpretation of the effects of drive and incentive-motivation on general activity and instrumental behavior Psychol Rev 75 1968 1 22
13. 9-tetrahydrocannabinol on the synthesis of dopamine and norepinephrine in mouse brain synaptosomes J Pharmacol Exp Ther 221 1982 97 103
14. 9-tetrahydrocannabinol in the mouse Psychopharmacology 57 1978 243 248
15. A.S. Bloom, W.L. Dewey, L.S. Harris, and K.K. Brosius 9-Nor-9beta-hydroxyhexahydrocannabinol, a cannabinoid with potent antinociceptive activity: comparisons with morphine J Pharmacol Exp Ther 200 1977 263 270
16. K. Blum, J.G. Cull, E.R. Braverman, and D.E. Comings Reward deficiency syndrome Am Sci 84 1996 132 145
17. K. Blum, P.J. Sheridan, R.C. Wood, E.R. Braverman, T.J. Chen, and J.G. Cull The D2 dopamine receptor gene as a determinant of reward deficiency syndrome J R Soc Med 89 1996 396 400
18. M.A. Bozarth, and R.A. Wise Anatomically distinct opiate receptor fields mediate reward and physical dependence Science 244 1984 516 517
19. J.V. Brady, and S.E. Lucas Testing drugs for physical dependence potential and abuse liability NIDA Res Monogr vol. 52 1984 U.S. Government Printing Office Washington, DC
20. J.V. Brady, R.R. Griffiths, R.D. Hienz, N.A. Ator, S.E. Lukas, and R.J. Lamb Assessing drugs for abuse liability and dependence potential in laboratory primates M.A. Bozarth Methods of assessing the reinforcing properties of abused drugs 1987 Springer-Verlag New York 45 85
21. D. Braida, M. Pozzi, R. Cavallini, and M. Sala Conditioned place preference induced by the cannabinoid agonist CP 55,940: interaction with the opioid system Neuroscience 104 2001 923 926
22. D. Braida, M. Pozzi, D. Parolaro, and M. Sala Intracerebral self-administration of the cannabinoid receptor agonist CP 55,940 in the rat: interaction with the opioid system Eur J Pharmacol 413 2001 227 234
23. C.S. Breivogel, G. Griffin, V. Di Marzo, and B.R. Martin Evidence for a new G protein-coupled cannabinoid receptor in mouse brain Mol Pharmacol 60 2001 155 163
24. A.K. Cadogan, S.P. Alexander, E.A. Boyd, and D.A. Kendall Influence of cannabinoids on electrically evoked dopamine release and cyclic AMP generation in the rat striatum J Neurochem 69 1997 1131 1137
25. M. Cador, T.W. Robbins, and B.J. Everitt Involvement of the amygdala in stimulus-reward associations: interaction with the ventral striatum Neuroscience 30 1989 77 86
26. P. Calabresi, R. Maj, A. Pisani, N.B. Mercuri, and G. Bernardi Long-term synaptic depression in the striatum: physiological and pharmacological characterization J Neurosci 12 1992 4224 4233
27. D.S. Cannon, and L.E. Carrell Rat strain differences in ethanol self-administration and taste aversion Pharmacol Biochem Behav 28 1987 57 63
28. W.A. Carlezon Jr., and R.A. Wise Rewarding actions of phencyclidine and related drugs in nucleus accumbens shell and frontal cortex J Neurosci 16 1996 3112 3122
29. W.A. Carlezon Jr., and R.A. Wise Microinjections of phencyclidine (PCP) and related drugs into nucleus accumbens shell potentiate medial forebrain bundle brain stimulation reward Psychopharmacology 128 1996 413 420
30. J.M. Carney, I.M. Uwaydah, and R.L. Balster Evaluation of a suspension system for intravenous self-administration of water insoluble substances in the rhesus monkey Pharmacol Biochem Behav 7 1977 357 364
31. E. Castañeda, D.E. Moss, S.D. Oddie, and I.Q. Whishaw THC does not affect striatal dopamine release: microdialysis in freely moving rats Pharmacol Biochem Behav 40 1991 587 591
32. 1) receptors in the establishment of place conditioning in rats Psychopharmacology 135 1998 324 332
33. J.F. Cheer, D.A. Kendall, and C.A. Marsden Cannabinoid receptors and reward in the rat: a conditioned place preference study Psychopharmacology 151 2000 25 30
34. J.F. Cheer, C.A. Marsden, D.A. Kendall, and R. Mason Lack of response suppression follows repeated ventral tegmental cannabinoid administration: an in vitro electrophysiological study Neuroscience 99 2000 661 667
35. 9-tetrahydrocannabinol on presynaptic dopamine efflux in nucleus accumbens of the Lewis rat Soc Neurosci Abstr 15 1989 1096
36. 9- Tetrahydrocannabinol enhances presynaptic dopamine efflux in medial prefrontal cortex Eur J Pharmacol 190 1990 259 262
37. 9-Tetrahydrocannabinol produces naloxone-blockable enhancement of presynaptic basal dopamine efflux in nucleus accumbens of conscious, freely-moving rats as measured by intracerebral microdialysis Psychopharmacology 102 1990 156 162
38. 9-tetrahydrocannabinol in the nucleus accumbens of rat: an in vivo microdialysis study Neurosci Lett 129 1991 136 140
39. 9-tetrahydrocannabinol enhances ventral tegmental somatodendritic dopamine levels but not forebrain dopamine levels: evidence for local neural action by marijuana's psychoactive ingredient Brain Res 621 1993 65 70
40. 9- Tetrahydrocannabinol's enhancement of nucleus accumbens dopamine resembles that of reuptake blockers rather than releasers-evidence from in vivo microdialysis experiments with 3-methoxytyramine NIDA Res Monogr 141 1994 312
41. B. Chieng, and J.T. Williams Increased opioid inhibition of GABA release in nucleus accumbens during morphine withdrawal J Neurosci 18 1998 7033 7039
42. S.R. Childers, L. Fleming, C. Konkoy, D. Marckel, M. Pacheco, and T. Sexton Opioid and cannabinoid receptor inhibition of adenylyl cyclase in brain Ann N Y Acad Sci 654 1992 33 51
43. S. Choi, and D.M. Lovinger Decreased probability of neurotransmitter release underlies striatal long-term depression and postnatal development of corticostriatal synapses Proc Natl Acad Sci U S A 94 1997 2665 2670
44. 9- tetrahydrocannabinol J Pharmacol Exp Ther 285 1998 1150 1156
45. M.E. Corcoran, and Z. Amit Reluctance of rats to drink hashish suspensions: free-choice and forced consumption, and the effects of hypothalamic stimulation Psychopharmacologia 35 1974 129 147
46. T.J. Crowley, M.J. Macdonald, E.A. Whitmore, and S.K. Mikulich Cannabis dependence, withdrawal, and reinforcing effects among adolescents with conduct symptoms and substance use disorders Drug Alcohol Depend 50 1998 27 37
47. 9-tetrahydrocannabinol (THC) in rhesus monkeys Pharmacologist 13 1971 246
48. T.J. De Vries, Y. Shaham, J.R. Homberg, H. Crombag, K. Schuurman, and J. Dieben A cannabinoid mechanism in relapse to cocaine seeking Nat Med 7 2001 1151 1154
49. S.L. Dewey, A.E. Morgan, C.R. Ashby Jr., B. Horan, S.A. Kushner, and J. Logan A novel strategy for the treatment of cocaine addiction Synapse 30 1998 119 129
50. S.L. Dewey, J.D. Brodie, M. Gerasimov, B. Horan, E.L. Gardner, and C.R. Ashby Jr. A pharmacologic strategy for the treatment of nicotine addiction Synapse 31 1999 76 86
51. H. de Wit, and J. Stewart Reinstatement of cocaine-reinforced responding in the rat Psychopharmacology 75 1981 134 143
52. H. de Wit, and J. Stewart Drug reinstatement of heroin-reinforced responding in the rat Psychopharmacology 79 1983 29 31
53. M. Diana, M. Melis, and G.L. Gessa Increase in meso-prefrontal dopaminergic activity after stimulation of CB1 receptors by cannabinoids Eur J Neurosci 10 1998 2825 2830
54. M. Diana, M. Melis, A.L. Muntoni, and G.L. Gessa Mesolimbic dopaminergic decline after cannabinoid withdrawal Proc Natl Acad Sci U S A 95 1998 10269 10273
55. G. Di Chiara The role of dopamine in drug abuse viewed from the perspective of its role in motivation Drug Alcohol Depend 38 1995 95 137
56. G. Di Chiara Drug addiction as dopamine-dependent associative learning disorder Eur J Pharmacol 375 1999 13 30
57. G. Di Chiara, and A. Imperato Preferential stimulation of dopamine release in the nucleus accumbens by opiates, alcohol, and barbiturates: studies with transcerebral dialysis in freely moving rats Ann N Y Acad Sci 473 1986 367 381
58. V. Di Marzo, D. Melck, T. Bisogno, and L. De Petrocellis Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action Trends Neurosci 21 1998 521 528
59. F. Dos Santos Villar, and J.P. Walsh Modulation of long-term synaptic plasticity at excitatory striatal synapses Neuroscience 90 1999 1031 1041
60. S. Erb, Y. Shaham, and J. Stewart Stress reinstates cocaine-seeking behavior after prolonged extinction and drug-free periods Psychopharmacology 128 1996 408 412
61. B.J. Everitt, M. Cador, and T.W. Robbins Interactions between the amygdala and ventral striatum in stimulus-reward associations: studies using a second-order schedule of sexual reinforcement Neuroscience 30 1989 63 75
62. B.J. Everitt, J.A. Parkinson, M.C. Olmstead, M. Arroyo, P. Robledo, and T.W. Robbins Associative processes in addiction and reward: the role of amygdala-ventral striatal subsystems Ann N Y Acad Sci 877 1999 412 438
63. B.J. Everitt, A. Dickinson, and T.W. Robbins The neuropsychological basis of addictive behaviour Brain Res Rev 36 2001 129 138
64. C.C. Felder, and M. Glass Cannabinoid receptors and their endogenous agonists Annu Rev Pharmacol Toxicol 38 1998 179 200
65. R.A. Frank, S. Martz, and T. Pommering The effect of chronic cocaine on self-stimulation train-duration thresholds Pharmacol Biochem Behav 29 1988 755 758
66. W. Fratta, M.C. Martellotta, G. Cossu, and L. Fattore WIN 55,212-2 induces intravenous self-administration in drug-naive mice Soc Neurosci Abstr 23 1997 1869
67. 9-Tetrahydrocannabinol excites rat VTA dopamine neurons through activation of cannabinoid CB1 but not opioid receptors Neurosci Lett 226 1997 159 162
68. E.D. French, K. Dillon, and X. Wu Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra Neuroreport 8 1997 649 652
69. T.F. Freund, I. Katona, and D. Piomelli Role of endogenous cannabinoids in synaptic signaling Physiol Rev 83 2003 1017 1066
70. P.J. Fudala, and E.T. Iwamoto Conditioned aversion after delay place conditioning with amphetamine Pharmacol Biochem Behav 35 1990 89 92
71. P.J. Fudala, K.W. Teoh, and E.T. Iwamoto Pharmacologic characterization of nicotine-induced conditioned place preference Pharmacol Biochem Behav 22 1985 237 241
72. D. Gaffan Amygdala and the memory of reward J.P. Aggleton The amygdala: neurobiological aspects of emotion 1992 Wiley New York 471 483
73. C.R. Gallistel, P. Shizgal, and J.S. Yeomans A portrait of the substrate for self-stimulation Psychol Rev 88 1981 228 273
74. Y. Gaoni, and R. Mechoulam Isolation, structure, and partial synthesis of an active constituent of hashish J Am Chem Soc 86 1964 1646
75. E.L. Gardner Cannabinoid interaction with brain reward systems-the neurobiological basis of cannabinoid abuse L.L. Murphy A. Bartke Marijuana/cannabinoids: neurobiology and neurophysiology 1992 CRC New York 275 335
76. E.L. Gardner Brain reward mechanisms J.H. Lowinson P. Ruiz R.B. Millman J.G. Langrod Substance abuse: a comprehensive textbook 3rd edn. 1997 Williams & Wilkins Baltimore 51 85
77. E.L. Gardner The neurobiology and genetics of addiction: implications of the "reward deficiency syndrome" for therapeutic strategies in chemical dependency J. Elster Addiction: entries and exits 1999 Russell Sage New York 57 119
78. E.L. Gardner What we have learned about addiction from animal models of drug self-administration Am J Addict 9 2000 285 313
79. E.L. Gardner, and J.H. Lowinson Marijuana's interaction with brain reward systems: update 1991 Pharmacol Biochem Behav 40 1991 571 580
80. E.L. Gardner, and J.H. Lowinson Drug craving and positive/negative hedonic brain substrates activated by addicting drugs Semin Neurosci 5 1993 359 368
81. E.L. Gardner, and S.R. Vorel Cannabinoid transmission and reward-related events Neurobiol Dis 5 1998 502 533
82. 9- tetrahydrocannabinol Psychopharmacology 96 1988 142 144
83. 9-tetrahydrocannabinol in laboratory rats Psychopharmacology 96 1988 365 [suppl.]
84. 9- tetrahydrocannabinol in laboratory rats is mirrored by strain-specific facilitation of presynaptic dopamine efflux in nucleus accumbens Soc Neurosci Abstr 15 1989 638
85. 9-tetrahydrocannabinol is mediated by an endogenous opioid mechanism Adv Biosci 75 1989 671 674
86. 9- tetrahydrocannabinol is mediated by an endogenous opioid mechanism J.M. van Ree A.H. Mulder V.M. Wiegant T.B. van Wimersma Greidanus New leads in opioid research 1990 Elsevier Amsterdam 243 245
87. 9-tetrahydrocannabinol as a dopamine reuptake blocker: brain microdialysis studies Soc Neurosci Abstr 16 1990 1100
88. E.L. Gardner, J. Chen, and W. Paredes Overview of chemical sampling techniques J Neurosci Methods 48 1993 173 197
89. F.R. George Genetic and environmental factors in ethanol self-administration Pharmacol Biochem Behav 27 1987 379 384
90. F.R. George, and S.R. Goldberg Genetic approaches to the analysis of addiction processes Trends Pharmacol Sci 10 1989 78 83
91. F.R. George, and R.A. Meisch Oral narcotic intake as a reinforcer: genotype × environment interaction Behav Genet 14 1984 603
92. G.L. Gerdeman, J. Ronesi, and D.M. Lovinger Post-synaptic endocannabinoid release is critical to long-term depression in the striatum Nat Neurosci 5 2002 446 451
93. G.L. Gerdeman, J.G. Partridge, C.R. Lupica, and D.M. Lovinger It could be habit forming: drugs of abuse and striatal synaptic plasticity Trends Neurosci 26 2003 184 192
94. G.L. Gessa, and M. Diana Different mechanisms for dopaminergic excitation induced by opiates and cannabinoids in the rat midbrain Prog Neuropsychopharmacol Biol Psychiatry 24 2000 993 1006
95. 1 receptors Eur J Pharmacol 341 1998 39 44
96. 9-tetrahydrocannabinol on the activity of A10 dopamine neurons recorded in vivo in anesthetized rats Neuropsychobiology 36 1997 96 99
97. A. Giuffrida, L.H. Parsons, T.M. Kerr, F. Rodríguez de Fonseca, M. Navarro, and D. Piomelli Dopamine activation of endogenous cannabinoid signaling in dorsal striatum Nat Neurosci 2 1999 358 363
98. A. Goldstein Addiction: from biology to drug policy 2nd ed. 2001 Oxford University Press New York
99. A. Goldstein, and H. Kalant Drug policy: striking the right balance Science 249 1990 1513 1521
100. F.G. Gonon Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry Neuroscience 24 1988 19 28
101. J. Grenhoff, G. Aston-Jones, and T.H. Svensson Nicotinic effects on the firing pattern of midbrain dopamine neurons Acta Physiol Scand 128 1986 351 358
102. R.R. Griffiths, C.E. Bigelow, and I. Liebson Experimental drug self-administration: generality across species and type of drug NIDA Res Monogr 20 1978 24 43
103. J.W. Grimm, and R.E. See Dissociation of primary and secondary reward-relevant limbic nuclei in an animal model of relapse Neuropsychopharmacology 22 2000 473 479
104. X. Guitart, D. Beitner-Johnson, D.W. Marby, T.A. Kosten, and E.J. Nestler Fischer and Lewis rat strains differ in basal levels of neurofilament proteins and in their regulation by chronic morphine in the mesolimbic dopamine system Synapse 12 1992 242 253
105. X. Guitart, J.H. Kogan, M. Berhow, R.Z. Terwilliger, G.K. Aghajanian, and E.J. Nestler Lewis and Fischer rat strains display differences in biochemical, electrophysiological and behavioral parameters: studies in the nucleus accumbens and locus coeruleus of drug naive and morphine-treated animals Brain Res 611 1993 7 17
106. K. Gysling, and R.Y. Wang Morphine-induced activation of A10 dopamine neurons in the rat Brain Res 277 1983 119 127
107. N. Hajos, and T.F. Freund Pharmacological separation of cannabinoid sensitive receptors on hippocampal excitatory and inhibitory fibers Neuropharmacology 43 2002 503 510
108. N. Hajos, C. Ledent, and T.F. Freund Novel cannabinoid sensitive receptor mediates inhibition of glutamatergic synaptic transmission in this hippocampus Neuroscience 106 2001 1 4
109. W. Hall, N. Solowij, and J. Lemon The health and psychological consequences of cannabis use National Drug Strategy Monograph Series vol. 25 1994 Australian Government Publishing Service Canberra
110. 9-tetrahydrocannabinol in monkeys Psychopharmacologia 37 1974 23 29
111. 1 and NMDA receptors promotes presynaptic inhibition in the rat nucleus accumbens via adenosine release J Neurosci 17 1997 5271 5280
112. R.J. Hayes, S.R. Vorel, J. Spector, X. Liu, and E.L. Gardner Electrical and chemical stimulation of the basolateral complex of the amygdala reinstates cocaine-seeking behavior Psychopharmacology 168 2003 75 83
113. D.J. Heal, A.T.J. Frankland, and W.R. Buckett A new and highly sensitive method for measuring 3-methoxytyramine using HPLC with electrochemical detection: studies with drugs which alter dopamine metabolism in the brain Neuropharmacology 29 1990 1141 1150
114. L. Heimer, D.S. Zahm, L. Churchill, P.W. Kalivas, and C. Wohltmann Specificity of the projection patterns of accumbal core and shell in the rat Neuroscience 41 1991 89 125
115. D.J. Henry, and C. Chavkin Activation of inwardly rectifying potassium channels (GIRK1) by co-expressed rat brain cannabinoid receptors in Xenopus oocytes Neurosci Lett 186 1995 91 94
116. M. Herkenham, A.B. Lynn, M.D. Little, M.R. Johnson, L.S. Melvin, and B.R. de Costa Cannabinoid receptor localization in brain Proc Natl Acad Sci U S A 87 1990 1932 1936
117. M. Herkenham, A.B. Lynn, M.R. Johnson, L.S. Melvin, B.R. de Costa, and K.C. Rice Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study J Neurosci 11 1991 563 583
118. 1- tetrahydrocannabinol and psychoactive drugs: effects on uptake of biogenic amines and on behavior Eur J Pharmacol 59 1979 267 276
119. M. Hershkowitz, R. Goldman, and A. Raz Effect of cannabinoids on neurotransmitter uptake, ATPase activity and morphology of mouse brain synaptosomes Biochem Pharmacol 26 1977 1327 1331
120. N. Hiroi, and N.M. White The lateral nucleus of the amygdala mediates expression of the amphetamine conditioned place preference J Neurosci 11 1991 2107 2116
121. A synaptic transmission in the hippocampus J Neurosci 20 2000 2470 2479
122. A.F. Hoffman, and C.R. Lupica Direct actions of cannabinoids on synaptic transmission in the nucleus accumbens: a comparison with opioids J Neurophysiol 85 2001 72 83
123. A.G. Hohmann, and M. Herkenham Localization of cannabinoid CB1 receptor mRNA in neuronal subpopulations of rat striatum: a double-label in situ hybridization study Synapse 37 2000 71 80
124. 9-tetrahydrocannabinol Br J Pharmacol 125 1998 1567 1577
125. S. Ikemoto Involvement of the olfactory tubercle in cocaine reward: intracranial self-administration studies J Neurosci 23 2003 9305 9311
126. S. Ikemoto, and R.A. Wise Mapping of chemical trigger zones for reward Neuropharmacology 47 2004 190 201
127. 9- tetrahydrocannabinol-induced increases in dopamine utilization in rat prefrontal cortex Synapse 28 1998 21 26
128. K.M. Johnson, W.L. Dewey, and L.S. Harris Some structural requirements for inhibition of high-affinity synaptosomal serotonin uptake by cannabinoids Mol Pharmacol 12 1976 345 352
129. P.I. Johnson, J.B. Goodman, R. Condon, and J.R. Stellar Reward shifts and motor responses following microinjections of opiate-specific agonists into either the core or shell of the nucleus accumbens Psychopharmacology 120 1995 195 202
130. S.W. Johnson, and R.A. North Opioids excite dopamine neurons by hyperpolarization of local interneurons J Neurosci 12 1992 483 488
131. D.E. Jorenby, R.E. Steinpreis, J.E. Sherman, and T.B. Baker Aversion instead of preference learning indicated by nicotine place conditioning in rats Psychopharmacology 101 1990 533 538
132. 9-tetrahydrocannabinol (THC) by drug naive squirrel monkeys Psychopharmacology 169 2003 135 140
133. 9- tetrahydrocannabinol (THC) in squirrel monkeys Psychopharmacology 173 2004 186 194
134. S.N. Katner, J.G. Magalong, and F. Weiss Reinstatement of alcohol-seeking behavior by drug-associated discriminative stimuli after prolonged extinction in the rat Neuropsychopharmacology 20 1999 471 479
135. S. Kaymakçalan Physiology and psychological dependence on THC in rhesus monkeys W.D.M. Paton J. Crown Cannabis and its derivatives 1972 Oxford University London 142 149
136. S. Kaymakçalan Tolerance to and dependence on cannabis Bull Narc 25 1973 39 47
137. J.N. Kerr, and J.R. Wickens Dopamine D-1/D-5 receptor activation is required for long-term potentiation in the rat neostriatum in vitro J Neurophysiol 85 2001 117 124
138. T. Khodzhagel'diev Formirovanie vlecheniia k nikotinu u myshei linii C57Bl/6 i CBA [Development of nicotine preference in C57Bl/6 and CBA mice] Biull Eksp Biol Med 101 1986 48 50
139. S.T. Kitai, P.D. Shepard, J.C. Callaway, and R. Scroogs Afferent modulation of dopamine neuron firing patterns Curr Opin Neurobiol 9 1999 690 697
140. H.D. Kleber Introduction-cocaine abuse: historical, epidemiological, and psychological perspectives J Clin Psychiatry 49 2 1988 3 6 [suppl.]
141. G.F. Koob Drug addiction: the yin and yang of hedonic homeostasis Neuron 16 1996 893 896
142. G.F. Koob The role of the striatopallidal and extended amygdala systems in drug addiction Ann N Y Acad Sci 877 1999 445 460
143. G.F. Koob, and M. Le Moal Drug abuse: hedonic homeostatic dysregulation Science 278 1997 52 58
144. G.F. Koob, A. Markou, F. Weiss, and G. Schulteis Opponent process and drug dependence: neurobiological mechanisms Semin Neurosci 5 1993 351 358
145. T. Koós, and J.M. Tepper Inhibitory control of neostriatal projection neurons by GABAergic interneurons Nat Neurosci 2 1999 467 472
146. C. Kornetsky, and G. Bain Brain-stimulation reward: a model for the study of the rewarding effects of abused drugs NIDA Res Monogr 124 1992 73 93
147. C. Kornetsky, and C. Duvauchelle Dopamine, a common substrate for the rewarding effects of brain stimulation reward, cocaine, and morphine NIDA Res Monogr 145 1994 19 39
148. T.A. Kosten, M.J. Miserendino, S. Chi, and E.J. Nestler Fischer and Lewis rat strains show differential cocaine effects in conditioned place preference and behavioral sensitization but not in locomotor activity or conditioned taste aversion J Pharmacol Exp Ther 269 1994 137 144
149. T.A. Kosten, M.J. Miserendino, C.N. Haile, J.L. DeCaprio, P.I. Jatlow, and E.J. Nestler Acquisition and maintenance of intravenous cocaine self-administration in Lewis and Fischer inbred rat strains Brain Res 778 1997 418 429
150. N.J. Kozel, and E.H. Adams Epidemiology of drug abuse: an overview Science 234 1986 970 974
151. J. Laszlo, V.S. Lucas, D.C. Hanson, C.M. Cronin, and S.E. Sallan Levonantradol for chemotherapy-induced emesis: phase I-II oral administration J Clin Pharmacol 21 8-9 1981 51S 56S [suppl.]
152. 1 receptor knockout mice Science 283 1999 401 404
153. J.R. Leite, and E.A. Carlini Failure to obtain "cannabis directed behavior" and abstinence syndrome in rats chronically treated with Cannabis sativa extracts Psychopharmacologia 36 1974 133 145
154. 9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward Life Sci 56 1995 2073 2080
155. 9-tetrahydrocannabinol-induced facilitation of brain stimulation reward as measured by a rate-frequency curve-shift electrical brain stimulation paradigm in three different rat strains Life Sci 58 1996 PL365 PL372
156. C.R. Lupica, A.C. Riegel, and A.F. Hoffman Marijuana and cannabinoid regulation of brain reward circuits Br J Pharmacol 143 2004 227 234
157. R. MacCoun, and P. Reuter Interpreting Dutch cannabis policy: reasoning by analogy in the legalization debate Science 278 1997 47 52
158. R.C. Malenka Synaptic plasticity and AMPA receptor trafficking Ann N Y Acad Sci 1003 2003 1 11
159. 9-Tetrahydrocannabinol, but not the endogenous cannabinoid receptor ligand anandamide, produces conditioned place aversion Life Sci 62 1998 2431 2439
160. 9-tetrahydrocannabinol: a microdialysis study in conscious rats Br J Pharmacol 128 1999 21 26
161. 9-tetrahydrocannabinol and CP 55,940 to maintain intravenous self-administration under a fixed-interval schedule in rhesus monkeys Behav Pharmacol 5 1994 219 225
162. O.J. Manzoni, and J. Bockaert Cannabinoids inhibit GABAergic synaptic transmission in mice nucleus accumbens Eur J Pharmacol 412 2001 R3 R5
163. M.C. Martellotta, G. Cossu, L. Fattore, G.L. Gessa, and W. Fratta Self-administration of the cannabinoid receptor agonist WIN 55,212-2 in drug-naive mice Neuroscience 85 1998 327 330
164. G. Martin, Z. Nie, and G.R. Siggins μ-Opioid receptors modulate NMDA receptor-mediated responses in nucleus accumbens neurons J Neurosci 17 1997 11 22
165. L.A. Matsuda, S.J. Lolait, M.J. Brownstein, A.C. Young, and T.I. Bonner Structure of a cannabinoid receptor and functional expression of the cloned cDNA Nature 346 1990 561 564
166. W.J. McBride, J.M. Murphy, and S. Ikemoto Localization of brain reinforcement mechanisms: intracranial self-administration and intracranial place-conditioning studies Behav Brain Res 101 1999 129 152
167. K. McFarland, and A. Ettenberg Reinstatement of drug-seeking behavior produced by heroin-predictive environmental stimuli Psychopharmacology 131 1997 86 92
168. I.S. McGregor, C.N. Issakidis, and G. Prior Aversive effects of the synthetic cannabinoid CP 55,940 in rats Pharmacol Biochem Behav 53 1996 657 664
169. R. Mchoulam, E. Fride, and V. Di Marzo Endocannabinoids Eur J Pharmacol 359 1998 1 18
170. W.M. Meil, and R.E. See Conditioned cued recovery of responding following prolonged withdrawal from self-administered cocaine in rats: an animal model of relapse Behav Pharmacol 7 1996 754 763
171. R.A. Meisch, and M.E. Carroll Oral drug self-administration: drugs as reinforcers M.A. Bozarth Methods of assessing the reinforcing properties of abused drugs 1987 Springer-Verlag New York 143 160
172. M. Melis, A.L. Muntoni, M. Diana, and G.L. Gessa The cannabinoid receptor agonist WIN 55,212-2 potently stimulates dopaminergic neuronal activity in the mesolimbic system Behav Pharmacol 7 suppl. 1 1996 68
173. M. Melis, M. Pistis, S. Perra, A.L. Muntoni, G. Pillolla, and G.L. Gessa Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in the rat ventral tegmental area dopamine neurons through activation of CB1 receptors J Neurosci 24 2004 53 62
174. E. Merlo Pich, M. Lorang, M. Yeganeh, F. Rodríguez de Fonseca, J. Raber, and G.F. Koob Increase in extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis J Neurosci 15 1995 5439 5447
175. P.R. Montague, P. Dayan, and T.J. Sejnowski A framework for mesencepahlic dopamine systems based on predictive Hebbian learning J Neurosci 16 1996 1936 1947
176. R.F. Mucha, D. van der Kooy, M. O'Shaughnessy, and P. Bucenieks Drug reinforcement studied by use of place conditioning in rat Brain Res 243 1982 91 105
177. Y. Munakata, and J. Pfaffly Hebbian learning and development Dev Sci 7 2004 141 148
178. S. Nakajima, X. Liu, and C.L. Lau Synergistic interaction of D1 and D2 dopamine receptors in the modulation of the reinforcing effect of brain stimulation Behav Neurosci 107 1993 161 165
179. T.C. Napier, and I. Mitrovic Opioid modulation of ventral pallidal inputs Ann N Y Acad Sci 877 1999 176 201
180. 9-tetrahydrocannabinol affects behavioral and neurochemical indices of mesolimbic dopaminergic activity Behav Brain Res 57 1993 37 46
181. 1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats Neuroreport 9 1998 3397 3402
182. E.J. Nestler Molecular mechanisms of drug addiction in the mesolimbic dopamine pathway Semin Neurosci 5 1993 369 376
183. J.M. Ng Cheong Ton, and E.L. Gardner Effects of delta-9- tetrahydrocannabinol on dopamine release in the brain: intracranial dialysis experiments Soc Neurosci Abstr 12 1986 135
184. 9-tetrahydrocannabinol on potassium-evoked release of dopamine in the rat caudate nucleus: an in vivo electrochemical and in vivo microdialysis study Brain Res 451 1988 59 68
185. S.M. Nicola, and R.C. Malenka Modulation of synaptic transmission by dopamine and norepinephrine in ventral but not dorsal striatum J Neurophysiol 79 1998 1768 1776
186. J.R. Noyes, S.F. Brunk, D.H. Avery, and A. Canter The analgesic properties of delta-9-tetrahydrocannabinol and codeine Clin Pharmacol Ther 18 1975 84 89
187. T. Ohno-Shosaku, J. Shosaku, H. Tsubokawa, and M. Kano Cooperative endocannabinoid production by neuronal depolarization and group I metabotropic glutamate receptor activation Eur J Neurosci 15 2002 953 961
188. P.G. Overton, and D. Clark Burst firing in midbrain dopaminergic neurons Brain Res Rev 25 1997 312 334
189. L.A. Parker, and T. Gillies THC-induced place and taste aversions in Lewis and Sprague-Dawley rats Behav Neurosci 109 1995 71 78
190. L.H. Parsons, A.D. Smith, and J.B. Justice Jr. Basal extracellular dopamine is decreased in the rat nucleus accumbens during abstinence from chronic cocaine Synapse 9 1991 60 65
191. O. Paulsen, and T.J. Sejnowski Natural patterns of activity and long-term synaptic plasticity Curr Opin Neurobiol 10 2000 172 179
192. L.L. Peoples, A.J. Uzwiak, F. Gee, A.T. Fabbricatore, K.J. Muccino, and B.D. Mohta Phasic accumbal firing may contribute to the regulation of drug taking during intravenous cocaine self-administration Ann N Y Acad Sci 877 1999 781 787
193. R.G. Pertwee Pharmacology of cannabinoid CB1 and CB2 receptors Pharmacol Ther 74 1997 129 180
194. R. Pickens, T. Thompson, and D.C. Muchow Cannabis and phencyclidine self-administered by animals L. Goldfarb F. Hoffmeister Psychic dependence [Bayer-Symposium IV] 1973 Springer-Verlag Berlin 78 86
195. D. Plenz Inhibition goes incognito: feedback interaction between spiny projection neurons in striatal function Trends Neurosci 26 2003 436 443
196. M.K. Poddar, and W.L. Dewey Effects of cannabinoids on catecholamine uptake and release in hypothalamus and striatal synaptosomes J Pharmacol Exp Ther 214 1980 63 67
197. F.E. Pontieri, G. Tanda, and G. Di Chiara Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens Proc Natl Acad Sci U S A 92 1995 12304 12308
198. E. Pothos, P. Rada, G.P. Mark, and B.G. Hoebel Dopamine microdialysis in the nucleus accumbens during acute and chronic morphine, naloxone-precipitated withdrawal and clonidine treatment Brain Res 566 1991 348 350
199. D. Raft, J. Gregg, J. Ghia, and L. Harris Effects of intravenous tetrahydrocannabinol on experimental and surgical pain. Psychological correlate of the analgesic response Clin Pharmacol Ther 21 1977 26 33
200. P. Redgrave, T.J. Prescott, and K. Gurney Is the short-latency dopamine response too short to signal reward error? Trends Neurosci 22 1999 146 151
201. J.N.J. Reynolds, and J.R. Wickens Dopamine-dependent plasticity of corticostriatal synapses Neural Netw 15 2002 507 521
202. J.N.J. Reynolds, B.I. Hyland, and J.R. Wickens A cellular mechanism of reward-related learning Nature 413 2001 67 70
203. N.R. Richardson, and D.C.S. Roberts Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy J Neurosci Methods 66 1996 1 11
204. B-mediated synaptic currents in midbrain dopamine neurons. Paper presented at meetings of the Society for Neuroscience, New Orleans, Louisiana, November 2003.
205. (Abstract published in 2003 Abstract Viewer/Itinerary Planner CD-ROM, the Thirty-Third Annual Meeting of the Society for Neuroscience, New Orleans, Louisiana, November 8-12, 2003, Society for Neuroscience, Washington, D.C., Program Abstract Number 462.6).
206. D. Robbe, M. Kopf, A. Remaury, J. Bockaert, and O.J. Manzoni Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens Proc Natl Acad Sci U S A 99 2002 8384 8388
207. T.W. Robbins, and B.J. Everitt Limbic-striatal memory systems and drug addiction Neurobiol Learn Mem 78 2002 625 636
208. D.C.S. Roberts, M.M. Andrews, and G.J. Vickers Baclofen attenuates the reinforcing effects of cocaine Neuropsychopharmacology 15 1996 417 423
209. T.E. Robinson, and K.C. Berridge The neural basis of drug craving: an incentive-sensitization theory of addiction Brain Res Rev 18 1993 247 291
210. F. Rodríguez de Fonseca, M.R.A. Carrera, M. Navarro, G.F. Koob, and F. Weiss Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal Science 276 1997 2050 2054
211. Z.L. Rossetti, Y. Hmaidan, and G.L. Gessa Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats Eur J Pharmacol 221 1992 227 234
212. T. Rubino, L. Tizzoni, D. Viganò, P. Massi, and D. Parolaro Modulation of rat brain cannabinoid receptors after chronic morphine treatment Neuroreport 8 1997 3219 3223
213. D. Saal, Y. Dong, A. Bonci, and R.C. Malenka Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons Neuron 37 2003 577 582
214. M.C. Sañudo-Peña, K. Tsou, E.R. Delay, A.G. Hohman, M. Force, and J.M. Walker Endogenous cannabinoids as an aversive or counter-rewarding system in the rat Neurosci Lett 223 1997 125 128
215. G.J. Schaefer, and R.P. Michael Changes in response rates and reinforcement thresholds for intracranial self-stimulation during morphine withdrawal Pharmacol Biochem Behav 25 1986 1263 1269
216. M.D. Schechter, and D.J. Calcagnetti Trends in place preference conditioning with a cross-indexed bibliography; 1957-1991 Neurosci Biobehav Rev 17 1993 21 41
217. G. Schulteis, A. Markou, L.H. Gold, L. Stinus, and G.F. Koob Relative sensitivity of multiple indices of opiate withdrawal: a quantitative dose-response analysis J Pharmacol Exp Ther 271 1994 1391 1398
218. W. Schultz, P. Dayan, and P.R. Montague A neural substrate of prediction and reward Science 275 1997 1593 1599
219. D.W. Self, and E.J. Nestler Molecular mechanisms of drug reinforcement and addiction Annu Rev Neurosci 18 1995 463 495
220. Y. Shaham, and J. Stewart Stress reinstates heroin-seeking in drug-free animals: an effect mimicking heroin, not withdrawal Psychopharmacology 119 1995 334 341
221. Y. Shaham, H. Rajabi, and J. Stewart Relapse to heroin-seeking in rats under opioid maintenance: the effects of stress, heroin-priming, and withdrawal J Neurosci 16 1996 1957 1963
222. U. Shalev, J.W. Grimm, and Y. Shaham Neurobiology of relapse to heroin and cocaine seeking: a review Pharmacol Rev 54 2002 1 42
223. P. Shizgal Neural basis of utility estimation Curr Opin Neurobiol 7 1997 198 208
224. P.A. Shore, B.A. McMillen, H.H. Miller, M.K. Sanghera, R.S. Kiserand, and D.C. German The dopamine neuronal storage system and non-amphetamine psychotogenic stimulants: a model for psychosis E. Usdin I.J. Kopin J. Barchas Catecholamines: basic and clinical frontiers 1979 Pergamon Press New York 722 735
225. D. Simon, and E. Burns The corner: a year in the life of an inner-city neighborhood 1997 Broadway Books (Random House) New York
226. P.K. Stanton LTD, LTP, and the sliding threshold for long-term synaptic plasticity Hippocampus 6 1996 35 42
227. J. Stewart Reinstatement of heroin and cocaine self-administration behavior in the rat by intracerebral application of morphine in the ventral tegmental area Pharmacol Biochem Behav 20 1984 917 923
228. J. Stewart, and H. de Wit Reinstatement of drug-taking behavior as a method of assessing incentive motivational properties of drugs M.A. Bozarth Methods of assessing the reinforcing properties of abused drugs 1987 Springer-Verlag New York 211 227
229. J. Stewart, and P. Vezina A comparison of the effects of intra-accumbens injections of amphetamine and morphine on reinstatement of heroin intravenous self-administration behavior Brain Res 457 1988 287 294
230. B receptors originate from discrete afferent neurons Neurosci Lett 134 1992 207 211
231. T. Suzuki, F.R. George, and R.A. Meisch Differential establishment and maintenance of oral ethanol reinforced behavior in Lewis and Fischer 344 inbred rat strains J Pharmacol Exp Ther 245 1989 164 170
232. B. Szabo, T. Muller, and H. Koch Effects of cannabinoids on dopamine release in the corpus striatum and the nucleus accumbens in vitro J Neurochem 73 1999 1084 1089
233. B. Szabo, S. Siemes, and I. Wallmichrath Inhibition of GABAergic neurotransmission in the ventral tegmental area by cannabinoids Eur J Neurosci 15 2002 2057 2061
234. 9- tetrahydrocannabinol by rats Pharmacol Biochem Behav 11 1979 737 740
235. R.N. Takahashi, and G. Singer Effects of body weight levels on cannabis self-administration Pharmacol Biochem Behav 13 1980 877 881
236. R.N. Takahashi, and G. Singer Cross self-administration of delta 9-tetrahydrocannabinol and D-amphetamine in rats Braz J Med Biol Res 14 1981 395 400
237. 1 opioid receptor mechanism Science 276 1997 2048 2050
238. 9-tetrahydrocannabinol Eur J Pharmacol 376 1999 23 26
239. G. Tanda, P. Munzar, and S.R. Goldberg Self-administration behavior is maintained by the psychoactive ingredient in marijuana in squirrel monkeys Nat Neurosci 3 2000 1073 1074
240. K.-C. Tang, M.J. Low, D.K. Grandy, and D.M. Lovinger Dopamine-dependent synaptic plasticity in striatum during in vivo development Proc Natl Acad Sci U S A 98 2001 1255 1260
241. D.A. Taylor, B.R. Sitaram, and S. Elliot-Baker Effect of Δ-9-tetrahydrocannabinol on release of dopamine in the corpus striatum of the rat G. Chesher P. Consroe R. Musty Marijuana: an international research report 1988 Australian Government Publishing Canberra 405 408
242. P.K. Thanos, N.D. Volkow, P. Freimuth, H. Umegaki, H. Ikari, and G. Roth Overexpression of dopamine D2 receptors reduces alcohol self-administration J Neurochem 78 2001 1094 1103
243. M.J. Thomas, C. Beurrier, A. Bonci, and R.C. Malenka Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine Nat Neurosci 4 2001 1217 1223
244. 9-tetrahydrocannabinol in mice Eur J Pharmacol 260 1994 5 13
245. K. Tsou, S.L. Patrick, and J.M. Walker Physical withdrawal in rats tolerant to delta 9-tetrahydrocannabinol precipitated by a cannabinoid receptor antagonist Eur J Pharmacol 280 1995 R13 R15
246. W. Twitchell, S. Brown, and K. Mackie Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons J Neurophysiol 78 1997 43 50
247. E.T. Tzavara, E. Valjent, C. Firmo, M. Mas, F. Beslot, and N. Defer Cannabinoid withdrawal is dependent upon PKA activation in the cerebellum Eur J Neurosci 12 2000 1038 1046
248. T.M. Tzschentke Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues Prog Neurobiol 56 1998 613 672
249. G. Uhl, K. Blum, E. Noble, and S. Smith Substance abuse vulnerability and D2 receptor genes Trends Neurosci 16 1993 83 88
250. 9-tetrahydrocannabinol in mice Psychopharmacology 147 2000 436 438
251. D. van der Kooy Place conditioning: a simple and effective method for assessing the motivational properties of drugs M.A. Bozarth Methods of assessing the reinforcing properties of abused drugs 1987 Springer-Verlag New York 229 240
252. P.J.-J. Vaysse, E.L. Gardner, and R.S. Zukin Modulation of rat brain opioid receptors by cannabinoids J Pharmacol Exp Ther 241 1987 534 539
253. N.D. Volkow, G.-J. Wang, J.S. Fowler, J. Logan, R.J. Hitzemann, and Y.-S. Ding Decreases in dopamine receptors but not in dopamine transporters in alcoholics Alcohol Clin Exp Res 20 1996 1594 1598
254. N.D. Volkow, G.-J. Wang, J.S. Fowler, J. Logan, S.J. Gatley, and R.J. Hitzemann Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects Nature 386 1997 830 833
255. 2 receptor levels Am J Psychiatry 156 1999 1440 1443
256. 2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex Am J Psychiatry 158 2001 2015 2021
257. S.R. Vorel, X. Liu, R.J. Hayes, J.A. Spector, and E.L. Gardner Relapse to cocaine-seeking after hippocampal theta burst stimulation Science 292 2001 1175 1178
258. I. Walaas, and F. Fonnum Biochemical evidence for gamma-aminobutyrate containing fibres from the nucleus accumbens to the substantia nigra and ventral tegmental area in the rat Neuroscience 5 1980 63 72
259. J.R. Weeks, and R.J. Collins Screening for drug reinforcement using intravenous self-administration in the rat M.A. Bozarth Methods of assessing the reinforcing properties of abused drugs 1987 Springer-Verlag New York 35 43
260. T. Wenger, G. Moldrich, and S. Furst Neuromorphological background of cannabis addiction Brain Res Bull 61 2003 125 128
261. B.H. Westerink, J. Tuntler, G. Damsma, H. Rollema, and J.B. de Vries The use of tetrodotoxin for the characterization of drug-enhanced dopamine release in conscious rats studied by brain dialysis Naunyn-Schmiedeberg's Arch Pharmacol 336 1987 502 507
262. N.M. White, and N. Hiroi Amphetamine conditioned cue preference and the neurobiology of drug-seeking Semin Neurosci 5 1993 329 336
263. I. Wickelgren Getting the brain's attention Science 278 1997 35 37
264. R.I. Wilson, and R.A. Nicoll Endogenous cannabinoids mediate retrograde signaling at hippocampal synapses Nature 410 2001 588 592
265. R.I. Wilson, and R.A. Nicoll Endocannabinoid signaling in the brain Science 296 2002 678 682
266. R.A. Wise Addictive drugs and brain stimulation reward Annu Rev Neurosci 19 1996 319 340
267. R.A. Wise Dopamine, learning and motivation Nat Rev Neurosci 5 2004 1 12
268. R.A. Wise, and M.A. Bozarth Brain reward circuitry: four circuit elements "wired" in apparent series Brain Res Bull 12 1984 203 208
269. R.A. Wise, and E.L. Gardner Functional anatomy of substance-related disorders H. D'haenen J.A. den Boer P. Willner Biological psychiatry 2002 Wiley New York 509 522
270. R.A. Wise, and E.L. Gardner Animal models of addiction D.S. Charney E.J. Nestler Neurobiology of mental illness 2nd edn. 2004 Oxford University Press London 683 697
271. R.A. Wise, and E. Munn Withdrawal from chronic amphetamine elevates baseline intracranial self-stimulation thresholds Psychopharmacology 117 1995 130 136
272. R.A. Wise, A. Murray, and M.A. Bozarth Bromocriptine self-administration and bromocriptine-reinstatement of cocaine-trained and heroin-trained lever pressing in rats Psychopharmacology 100 1990 355 360
273. M.E. Wolf Addiction: making the connection between behavioral changes and neuronal plasticity in specific pathways Mol Interv 2 2002 146 157
274. P.L. Wood, and C.A. Altar Dopamine release in vivo from nigrostriatal, mesolimbic, and mesocortical neurons: utility of 3-methoxytyramine measurements Pharmacol Rev 40 1988 163 187
275. D.J. Woodward, J.Y. Chang, P. Janak, A. Azarov, and K. Anstrom Mesolimbic neuronal activity across behavioral states Ann N Y Acad Sci 877 1999 91 112
276. 9- tetrahydrocannabinol on rat midbrain neurons: an electrophysiological assessment Neuropharmacology 39 2000 391 398
277. Z.-X. Xi, and E.A. Stein Baclofen inhibits heroin self-administration behavior and mesolimbic dopamine release J Pharmacol Exp Ther 290 1999 1369 1374
278. T. Yanagita Prediction of drug abuse liability from animal studies M.A. Bozarth Methods of assessing the reinforcing properties of abused drugs 1987 Springer-Verlag New York 189 198
279. R.A. Yokel Intravenous self-administration: response rates, the effects of pharmacological challenges, and drug preferences M.A. Bozarth Methods of assessing the reinforcing properties of abused drugs 1987 Springer-Verlag New York 1 33