-
1
-
-
84916199585
-
Targeting vascular endothelial growth factor (VEGF) pathway in gastric cancer: Preclinical and clinical aspects
-
O. Abdel-Rahman Targeting vascular endothelial growth factor (VEGF) pathway in gastric cancer: preclinical and clinical aspects Crit Rev Oncol Hematol 93 1 2015 18 27
-
(2015)
Crit Rev Oncol Hematol
, vol.93
, Issue.1
, pp. 18-27
-
-
Abdel-Rahman, O.1
-
2
-
-
33847026354
-
Autophagy delays apoptotic death in breast cancer cells following DNA damage
-
M.J. Abedin, D. Wang, M.A. McDonnell, U. Lehmann, and A. Kelekar Autophagy delays apoptotic death in breast cancer cells following DNA damage Cell Death Differ 14 3 2007 500 510
-
(2007)
Cell Death Differ
, vol.14
, Issue.3
, pp. 500-510
-
-
Abedin, M.J.1
Wang, D.2
McDonnell, M.A.3
Lehmann, U.4
Kelekar, A.5
-
3
-
-
84974713945
-
In vitro and in vivo radiosensitization by FGFR-1 inhibition using the antagonist SSR128129E in human glioblastoma models
-
I. Ader, C. Delmas, N. Skuli, F. Darlot, G. Favre, and F. Bono In vitro and in vivo radiosensitization by FGFR-1 inhibition using the antagonist SSR128129E in human glioblastoma models Neuro-Oncology 12 Suppl. 4 2010
-
(2010)
Neuro-Oncology
, vol.12
, Issue.SUPPL. 4
-
-
Ader, I.1
Delmas, C.2
Skuli, N.3
Darlot, F.4
Favre, G.5
Bono, F.6
-
4
-
-
84905099678
-
Preclinical evidence that SSR128129E - A novel small-molecule multi-fibroblast growth factor receptor blocker - Radiosensitises human glioblastoma
-
I. Ader, C. Delmas, N. Skuli, J. Bonnet, P. Schaeffer, and F. Bono Preclinical evidence that SSR128129E - a novel small-molecule multi-fibroblast growth factor receptor blocker - radiosensitises human glioblastoma Eur J Cancer 50 13 2014 2351 2359
-
(2014)
Eur J Cancer
, vol.50
, Issue.13
, pp. 2351-2359
-
-
Ader, I.1
Delmas, C.2
Skuli, N.3
Bonnet, J.4
Schaeffer, P.5
Bono, F.6
-
5
-
-
84896091512
-
ERBB receptors: From oncogene discovery to basic science to mechanism-based cancer therapeutics
-
C.L. Arteaga, and J.A. Engelman ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics Cancer Cell 25 3 2014 282 303
-
(2014)
Cancer Cell
, vol.25
, Issue.3
, pp. 282-303
-
-
Arteaga, C.L.1
Engelman, J.A.2
-
6
-
-
0034671927
-
Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-beta1-mediated angiogenesis
-
R. Bagheri-Yarmand, R.K. Vadlamudi, R.A. Wang, J. Mendelsohn, and R. Kumar Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-beta1-mediated angiogenesis J Biol Chem 275 50 2000 39451 39457
-
(2000)
J Biol Chem
, vol.275
, Issue.50
, pp. 39451-39457
-
-
Bagheri-Yarmand, R.1
Vadlamudi, R.K.2
Wang, R.A.3
Mendelsohn, J.4
Kumar, R.5
-
7
-
-
19644376976
-
Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells
-
K. Beppu, K. Nakamura, W.M. Linehan, A. Rapisarda, and C.J. Thiele Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells Cancer Res 65 11 2005 4775 4781
-
(2005)
Cancer Res
, vol.65
, Issue.11
, pp. 4775-4781
-
-
Beppu, K.1
Nakamura, K.2
Linehan, W.M.3
Rapisarda, A.4
Thiele, C.J.5
-
8
-
-
0030207118
-
Signaling via the insulin-like growth factor-I receptor: Does it differ from insulin receptor signaling?
-
V.A. Blakesley, A. Scrimgeour, D. Esposito, and D. Le Roith Signaling via the insulin-like growth factor-I receptor: does it differ from insulin receptor signaling? Cytokine Growth Factor Rev 7 2 1996 153 159
-
(1996)
Cytokine Growth Factor Rev
, vol.7
, Issue.2
, pp. 153-159
-
-
Blakesley, V.A.1
Scrimgeour, A.2
Esposito, D.3
Le Roith, D.4
-
9
-
-
84880255880
-
Hypoxia regulates FGFR3 expression via HIF-1α and miR-100 and contributes to cell survival in non-muscle invasive bladder cancer
-
C. Blick, A. Ramachandran, S. Wigfield, R. McCormick, A. Jubb, and F.M. Buffa Hypoxia regulates FGFR3 expression via HIF-1α and miR-100 and contributes to cell survival in non-muscle invasive bladder cancer Br J Cancer 109 1 2013 50 59
-
(2013)
Br J Cancer
, vol.109
, Issue.1
, pp. 50-59
-
-
Blick, C.1
Ramachandran, A.2
Wigfield, S.3
McCormick, R.4
Jubb, A.5
Buffa, F.M.6
-
10
-
-
33746504571
-
Invasive growth: A MET-driven genetic programme for cancer and stem cells
-
C. Boccaccio, and P.M. Comoglio Invasive growth: a MET-driven genetic programme for cancer and stem cells Nat Rev Cancer 6 8 2006 637 645
-
(2006)
Nat Rev Cancer
, vol.6
, Issue.8
, pp. 637-645
-
-
Boccaccio, C.1
Comoglio, P.M.2
-
11
-
-
0027412657
-
Mechanisms of elevation of adenosine levels in anoxic hepatocytes
-
F. Bontemps, M.F. Vincent, and G. Van den Berghe Mechanisms of elevation of adenosine levels in anoxic hepatocytes Biochem J 290 Pt 3 1993 671 677
-
(1993)
Biochem J
, vol.290
, Issue.PART 3
, pp. 671-677
-
-
Bontemps, F.1
Vincent, M.F.2
Van Den Berghe, G.3
-
12
-
-
84920282270
-
Digoxin use and the risk for colorectal cancer
-
B. Boursi, K. Haynes, R. Mamtani, and Y.X. Yang Digoxin use and the risk for colorectal cancer Pharmacoepidemiol Drug Saf 23 11 2014 1147 1153
-
(2014)
Pharmacoepidemiol Drug Saf
, vol.23
, Issue.11
, pp. 1147-1153
-
-
Boursi, B.1
Haynes, K.2
Mamtani, R.3
Yang, Y.X.4
-
13
-
-
51049089073
-
Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: Implications for STAT-3 activation and gene expression
-
E.C. Brantley, L.B. Nabors, G.Y. Gillespie, Y.H. Choi, C.A. Palmer, and K. Harrison Loss of protein inhibitors of activated STAT-3 expression in glioblastoma multiforme tumors: implications for STAT-3 activation and gene expression Clin Cancer Res 14 15 2008 4694 4704
-
(2008)
Clin Cancer Res
, vol.14
, Issue.15
, pp. 4694-4704
-
-
Brantley, E.C.1
Nabors, L.B.2
Gillespie, G.Y.3
Choi, Y.H.4
Palmer, C.A.5
Harrison, K.6
-
14
-
-
0026744303
-
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway
-
C. Bucci, R.G. Parton, I.H. Mather, H. Stunnenberg, K. Simons, and B. Hoflack The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway Cell 70 5 1992 715 728
-
(1992)
Cell
, vol.70
, Issue.5
, pp. 715-728
-
-
Bucci, C.1
Parton, R.G.2
Mather, I.H.3
Stunnenberg, H.4
Simons, K.5
Hoflack, B.6
-
15
-
-
77958603109
-
Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody: AMG102
-
I.M. Buchanan, T. Scott, A.T. Tandle, W.E. Burgan, T.L. Burgess, and P.J. Tofilon Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody: AMG102 J Cell Mol Med 15 9 2011 1999 2006
-
(2011)
J Cell Mol Med
, vol.15
, Issue.9
, pp. 1999-2006
-
-
Buchanan, I.M.1
Scott, T.2
Tandle, A.T.3
Burgan, W.E.4
Burgess, T.L.5
Tofilon, P.J.6
-
16
-
-
80052223077
-
MicroRNA-associated progression pathways and potential therapeutic targets identified by integrated mRNA and microRNA expression profiling in breast cancer
-
F.M. Buffa, C. Camps, L. Winchester, C.E. Snell, H.E. Gee, and H. Sheldon microRNA-associated progression pathways and potential therapeutic targets identified by integrated mRNA and microRNA expression profiling in breast cancer Cancer Res 71 17 2011 5635 5645
-
(2011)
Cancer Res
, vol.71
, Issue.17
, pp. 5635-5645
-
-
Buffa, F.M.1
Camps, C.2
Winchester, L.3
Snell, C.E.4
Gee, H.E.5
Sheldon, H.6
-
17
-
-
0029842459
-
Oxygen sensing and molecular adaptation to hypoxia
-
H.F. Bunn, and R.O. Poyton Oxygen sensing and molecular adaptation to hypoxia Physiol Rev 76 3 1996 839 885
-
(1996)
Physiol Rev
, vol.76
, Issue.3
, pp. 839-885
-
-
Bunn, H.F.1
Poyton, R.O.2
-
18
-
-
78650674666
-
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels
-
S. Buraschi, N. Pal, N. Tyler-Rubinstein, R.T. Owens, T. Neill, and R.V. Iozzo Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels J Biol Chem 285 53 2010 42075 42085
-
(2010)
J Biol Chem
, vol.285
, Issue.53
, pp. 42075-42085
-
-
Buraschi, S.1
Pal, N.2
Tyler-Rubinstein, N.3
Owens, R.T.4
Neill, T.5
Iozzo, R.V.6
-
19
-
-
33645504221
-
Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells
-
M. Calvani, A. Rapisarda, B. Uranchimeg, R.H. Shoemaker, and G. Melillo Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells Blood 107 7 2006 2705 2712
-
(2006)
Blood
, vol.107
, Issue.7
, pp. 2705-2712
-
-
Calvani, M.1
Rapisarda, A.2
Uranchimeg, B.3
Shoemaker, R.H.4
Melillo, G.5
-
20
-
-
0035399174
-
Oxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells
-
M.T. Canning, L.M. Postovit, S.H. Clarke, and C.H. Graham Oxygen-mediated regulation of gelatinase and tissue inhibitor of metalloproteinases-1 expression by invasive cells Exp Cell Res 267 1 2001 88 94
-
(2001)
Exp Cell Res
, vol.267
, Issue.1
, pp. 88-94
-
-
Canning, M.T.1
Postovit, L.M.2
Clarke, S.H.3
Graham, C.H.4
-
21
-
-
0032581277
-
Role of HIF-1alpha in hypoxia-mediated apoptosis: Cell proliferation and tumour angiogenesis
-
P. Carmeliet, Y. Dor, J.M. Herbert, D. Fukumura, K. Brusselmans, and M. Dewerchin Role of HIF-1alpha in hypoxia-mediated apoptosis: cell proliferation and tumour angiogenesis Nature 394 6692 1998 485 490
-
(1998)
Nature
, vol.394
, Issue.6692
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
-
22
-
-
84861520898
-
Spatial regulation of receptor tyrosine kinases in development and cancer
-
J.B. Casaletto, and A.I. McClatchey Spatial regulation of receptor tyrosine kinases in development and cancer Nat Rev Cancer 12 6 2012 387 400
-
(2012)
Nat Rev Cancer
, vol.12
, Issue.6
, pp. 387-400
-
-
Casaletto, J.B.1
McClatchey, A.I.2
-
23
-
-
70350536585
-
Distinct microRNA alterations characterize high- and low-grade bladder cancer
-
J.W. Catto, S. Miah, H.C. Owen, H. Bryant, K. Myers, and E. Dudziec Distinct microRNA alterations characterize high- and low-grade bladder cancer Cancer Res 69 21 2009 8472 8481
-
(2009)
Cancer Res
, vol.69
, Issue.21
, pp. 8472-8481
-
-
Catto, J.W.1
Miah, S.2
Owen, H.C.3
Bryant, H.4
Myers, K.5
Dudziec, E.6
-
24
-
-
84905964443
-
Hypoxia promotes nuclear translocation and transcriptional function in the oncogenic tyrosine kinase RON
-
H.Y. Chang, H.S. Liu, M.D. Lai, Y.S. Tsai, T.S. Tzai, and H.L. Cheng Hypoxia promotes nuclear translocation and transcriptional function in the oncogenic tyrosine kinase RON Cancer Res 74 16 2014 4549 4562
-
(2014)
Cancer Res
, vol.74
, Issue.16
, pp. 4549-4562
-
-
Chang, H.Y.1
Liu, H.S.2
Lai, M.D.3
Tsai, Y.S.4
Tzai, T.S.5
Cheng, H.L.6
-
25
-
-
84872494457
-
Hypoxia-inducible factor 1 alpha mediates epidermal growth factor-induced down-regulation of E-cadherin expression and cell invasion in human ovarian cancer cells
-
J.C. Cheng, C. Klausen, and P.C. Leung Hypoxia-inducible factor 1 alpha mediates epidermal growth factor-induced down-regulation of E-cadherin expression and cell invasion in human ovarian cancer cells Cancer Lett 329 2 2013 197 206
-
(2013)
Cancer Lett
, vol.329
, Issue.2
, pp. 197-206
-
-
Cheng, J.C.1
Klausen, C.2
Leung, P.C.3
-
26
-
-
56749110996
-
The type 1 insulin-like growth factor receptor pathway
-
M.M. Chitnis, J.S. Yuen, A.S. Protheroe, M. Pollak, and V.M. Macaulay The type 1 insulin-like growth factor receptor pathway Clin Cancer Res 14 20 2008 6364 6370
-
(2008)
Clin Cancer Res
, vol.14
, Issue.20
, pp. 6364-6370
-
-
Chitnis, M.M.1
Yuen, J.S.2
Protheroe, A.S.3
Pollak, M.4
Macaulay, V.M.5
-
27
-
-
68149084899
-
HIF-1alpha modulation by topoisomerase inhibitors in non-small cell lung cancer cell lines
-
Y.J. Choi, J.K. Rho, S.J. Lee, W.S. Jang, S.S. Lee, and C.H. Kim HIF-1alpha modulation by topoisomerase inhibitors in non-small cell lung cancer cell lines J Cancer Res Clin Oncol 135 8 2009 1047 1053
-
(2009)
J Cancer Res Clin Oncol
, vol.135
, Issue.8
, pp. 1047-1053
-
-
Choi, Y.J.1
Rho, J.K.2
Lee, S.J.3
Jang, W.S.4
Lee, S.S.5
Kim, C.H.6
-
28
-
-
80955158149
-
Receptor tyrosine kinases: From biology to pathology
-
M. Choura, and A. Rebai Receptor tyrosine kinases: from biology to pathology J Recept Signal Transduct Res 31 6 2011 387 394
-
(2011)
J Recept Signal Transduct Res
, vol.31
, Issue.6
, pp. 387-394
-
-
Choura, M.1
Rebai, A.2
-
29
-
-
79957698092
-
Aromatase, aromatase inhibitors, and breast cancer
-
S. Chumsri, T. Howes, T. Bao, G. Sabnis, and A. Brodie Aromatase, aromatase inhibitors, and breast cancer J Steroid Biochem Mol Biol 125 1-2 2011 13 22
-
(2011)
J Steroid Biochem Mol Biol
, vol.125
, Issue.12
, pp. 13-22
-
-
Chumsri, S.1
Howes, T.2
Bao, T.3
Sabnis, G.4
Brodie, A.5
-
30
-
-
77953988924
-
Targeting the tumour vasculature: Insights from physiological angiogenesis
-
A.S. Chung, J. Lee, and N. Ferrara Targeting the tumour vasculature: insights from physiological angiogenesis Nat Rev Cancer 10 7 2010 505 514
-
(2010)
Nat Rev Cancer
, vol.10
, Issue.7
, pp. 505-514
-
-
Chung, A.S.1
Lee, J.2
Ferrara, N.3
-
31
-
-
0032527802
-
Cooperative inhibition of renal cancer growth by anti-epidermal growth factor receptor antibody and protein kinase A antisense oligonucleotide
-
F. Ciardiello, R. Caputo, R. Bianco, V. Damiano, G. Pomatico, and S. Pepe Cooperative inhibition of renal cancer growth by anti-epidermal growth factor receptor antibody and protein kinase A antisense oligonucleotide J Natl Cancer Inst 90 14 1998 1087 1094
-
(1998)
J Natl Cancer Inst
, vol.90
, Issue.14
, pp. 1087-1094
-
-
Ciardiello, F.1
Caputo, R.2
Bianco, R.3
Damiano, V.4
Pomatico, G.5
Pepe, S.6
-
32
-
-
0034693263
-
Sustained down-regulation of the epidermal growth factor receptor by decorin. A mechanism for controlling tumor growth in vivo
-
G. Csordas, M. Santra, C.C. Reed, I. Eichstetter, D.J. McQuillan, and D. Gross Sustained down-regulation of the epidermal growth factor receptor by decorin. A mechanism for controlling tumor growth in vivo J Biol Chem 275 42 2000 32879 32887
-
(2000)
J Biol Chem
, vol.275
, Issue.42
, pp. 32879-32887
-
-
Csordas, G.1
Santra, M.2
Reed, C.C.3
Eichstetter, I.4
McQuillan, D.J.5
Gross, D.6
-
33
-
-
62449205665
-
Chemoresistant colorectal cancer cells: The cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition
-
N.A. Dallas, L. Xia, F. Fan, M.J. Gray, P. Gaur, and G. van Buren Chemoresistant colorectal cancer cells: the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition Cancer Res 69 5 2009 1951 1957
-
(2009)
Cancer Res
, vol.69
, Issue.5
, pp. 1951-1957
-
-
Dallas, N.A.1
Xia, L.2
Fan, F.3
Gray, M.J.4
Gaur, P.5
Van Buren, G.6
-
34
-
-
72149090432
-
Evaluating temsirolimus activity in multiple tumors: A review of clinical trials
-
J.E. Dancey, R. Curiel, and J. Purvis Evaluating temsirolimus activity in multiple tumors: a review of clinical trials Semin Oncol 36 Suppl. 3 2009 S46 S58
-
(2009)
Semin Oncol
, vol.36
, Issue.SUPPL. 3
, pp. S46-S58
-
-
Dancey, J.E.1
Curiel, R.2
Purvis, J.3
-
35
-
-
23844450576
-
A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma
-
B. Das, H. Yeger, R. Tsuchida, R. Torkin, M.F. Gee, and P.S. Thorner A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma Cancer Res 65 16 2005 7267 7275
-
(2005)
Cancer Res
, vol.65
, Issue.16
, pp. 7267-7275
-
-
Das, B.1
Yeger, H.2
Tsuchida, R.3
Torkin, R.4
Gee, M.F.5
Thorner, P.S.6
-
36
-
-
80054702141
-
Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3
-
C.R. Degnin, M.B. Laederich, and W.A. Horton Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3 Mol Biol Cell 22 20 2011 3861 3873
-
(2011)
Mol Biol Cell
, vol.22
, Issue.20
, pp. 3861-3873
-
-
Degnin, C.R.1
Laederich, M.B.2
Horton, W.A.3
-
37
-
-
33745242315
-
Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus
-
D. Del Bufalo, L. Ciuffreda, D. Trisciuoglio, M. Desideri, F. Cognetti, and G. Zupi Antiangiogenic potential of the Mammalian target of rapamycin inhibitor temsirolimus Cancer Res 66 11 2006 5549 5554
-
(2006)
Cancer Res
, vol.66
, Issue.11
, pp. 5549-5554
-
-
Del Bufalo, D.1
Ciuffreda, L.2
Trisciuoglio, D.3
Desideri, M.4
Cognetti, F.5
Zupi, G.6
-
38
-
-
0033970086
-
Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment
-
N. Denko, C. Schindler, A. Koong, K. Laderoute, C. Green, and A. Giaccia Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment Clin Cancer Res 6 2 2000 480 487
-
(2000)
Clin Cancer Res
, vol.6
, Issue.2
, pp. 480-487
-
-
Denko, N.1
Schindler, C.2
Koong, A.3
Laderoute, K.4
Green, C.5
Giaccia, A.6
-
39
-
-
84255199558
-
Phosphorylation of carbonic anhydrase IX controls its ability to mediate extracellular acidification in hypoxic tumors
-
P. Ditte, F. Dequiedt, E. Svastova, A. Hulikova, A. Ohradanova-Repic, and M. Zatovicova Phosphorylation of carbonic anhydrase IX controls its ability to mediate extracellular acidification in hypoxic tumors Cancer Res 71 24 2011 7558 7567
-
(2011)
Cancer Res
, vol.71
, Issue.24
, pp. 7558-7567
-
-
Ditte, P.1
Dequiedt, F.2
Svastova, E.3
Hulikova, A.4
Ohradanova-Repic, A.5
Zatovicova, M.6
-
40
-
-
80051800007
-
HGF-independent potentiation of EGFR action by c-Met
-
A.M. Dulak, C.T. Gubish, L.P. Stabile, C. Henry, and J.M. Siegfried HGF-independent potentiation of EGFR action by c-Met Oncogene 30 33 2011 3625 3635
-
(2011)
Oncogene
, vol.30
, Issue.33
, pp. 3625-3635
-
-
Dulak, A.M.1
Gubish, C.T.2
Stabile, L.P.3
Henry, C.4
Siegfried, J.M.5
-
41
-
-
84909991205
-
Targeting the insulin-like growth factor pathway in hepatocellular carcinoma
-
M. Enguita-Germán, and P. Fortes Targeting the insulin-like growth factor pathway in hepatocellular carcinoma World J Hepatol 6 10 2014 716 737
-
(2014)
World J Hepatol
, vol.6
, Issue.10
, pp. 716-737
-
-
Enguita-Germán, M.1
Fortes, P.2
-
42
-
-
84916912453
-
Targeting hypoxia-inducible factor-1alpha (HIF-1alpha) in combination with antiangiogenic therapy: A phase i trial of bortezomib plus bevacizumab
-
G.S. Falchook, J.J. Wheler, A. Naing, E.F. Jackson, F. Janku, and D. Hong Targeting hypoxia-inducible factor-1alpha (HIF-1alpha) in combination with antiangiogenic therapy: a phase I trial of bortezomib plus bevacizumab Oncotarget 5 21 2014 10280 10292
-
(2014)
Oncotarget
, vol.5
, Issue.21
, pp. 10280-10292
-
-
Falchook, G.S.1
Wheler, J.J.2
Naing, A.3
Jackson, E.F.4
Janku, F.5
Hong, D.6
-
43
-
-
0033566693
-
Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2
-
D. Feldser, F. Agani, N.V. Iyer, B. Pak, G. Ferreira, and G.L. Semenza Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2 Cancer Res 59 16 1999 3915 3918
-
(1999)
Cancer Res
, vol.59
, Issue.16
, pp. 3915-3918
-
-
Feldser, D.1
Agani, F.2
Iyer, N.V.3
Pak, B.4
Ferreira, G.5
Semenza, G.L.6
-
44
-
-
0036985699
-
Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: Therapeutic implications
-
N. Ferrara Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications Semin Oncol 29 6 Suppl. 16 2002 10 14
-
(2002)
Semin Oncol
, vol.29
, Issue.6 SUPPL. 16
, pp. 10-14
-
-
Ferrara, N.1
-
45
-
-
0031039243
-
The biology of vascular endothelial growth factor
-
N. Ferrara, and T. Davis-Smyth The biology of vascular endothelial growth factor Endocr Rev 18 1 1997 4 25
-
(1997)
Endocr Rev
, vol.18
, Issue.1
, pp. 4-25
-
-
Ferrara, N.1
Davis-Smyth, T.2
-
46
-
-
0034702178
-
Cross-talk between the proto-oncogenes Met and Ron
-
A. Follenzi, S. Bakovic, P. Gual, M.C. Stella, P. Longati, and P.M. Comoglio Cross-talk between the proto-oncogenes Met and Ron Oncogene 19 27 2000 3041 3049
-
(2000)
Oncogene
, vol.19
, Issue.27
, pp. 3041-3049
-
-
Follenzi, A.1
Bakovic, S.2
Gual, P.3
Stella, M.C.4
Longati, P.5
Comoglio, P.M.6
-
47
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
J.A. Forsythe, B.H. Jiang, N.V. Iyer, F. Agani, S.W. Leung, and R.D. Koos Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1 Mol Cell Biol 16 9 1996 4604 4613
-
(1996)
Mol Cell Biol
, vol.16
, Issue.9
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
Agani, F.4
Leung, S.W.5
Koos, R.D.6
-
48
-
-
34548803430
-
Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer
-
A. Franovic, L. Gunaratnam, K. Smith, I. Robert, D. Patten, and S. Lee Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer Proc Natl Acad Sci USA 104 32 2007 13092 13097
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.32
, pp. 13092-13097
-
-
Franovic, A.1
Gunaratnam, L.2
Smith, K.3
Robert, I.4
Patten, D.5
Lee, S.6
-
49
-
-
0037064010
-
Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression: Which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
-
R. Fukuda, K. Hirota, F. Fan, Y.D. Jung, L.M. Ellis, and G.L. Semenza Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression: which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells J Biol Chem 277 41 2002 38205 38211
-
(2002)
J Biol Chem
, vol.277
, Issue.41
, pp. 38205-38211
-
-
Fukuda, R.1
Hirota, K.2
Fan, F.3
Jung, Y.D.4
Ellis, L.M.5
Semenza, G.L.6
-
50
-
-
0035695318
-
Stimulation and inhibition of angiogenesis in diabetic retinopathy
-
H. Funatsu, H. Yamashita, H. Noma, E. Shimizu, T. Yamashita, and S. Hori Stimulation and inhibition of angiogenesis in diabetic retinopathy Jpn J Ophthalmol 45 6 2001 577 584
-
(2001)
Jpn J Ophthalmol
, vol.45
, Issue.6
, pp. 577-584
-
-
Funatsu, H.1
Yamashita, H.2
Noma, H.3
Shimizu, E.4
Yamashita, T.5
Hori, S.6
-
51
-
-
0346643472
-
Effects of the soluble guanylyl cyclase activator: YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity
-
J. Galle, U. Zabel, U. Hubner, A. Hatzelmann, B. Wagner, and C. Wanner Effects of the soluble guanylyl cyclase activator: YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity Br J Pharmacol 127 1 1999 195 203
-
(1999)
Br J Pharmacol
, vol.127
, Issue.1
, pp. 195-203
-
-
Galle, J.1
Zabel, U.2
Hubner, U.3
Hatzelmann, A.4
Wagner, B.5
Wanner, C.6
-
52
-
-
48649092035
-
Coupling of mutated met variants to DNA repair via Abl and Rad51
-
S.S. Ganapathipillai, M. Medova, D.M. Aebersold, P.W. Manley, S. Berthou, and B. Streit Coupling of mutated met variants to DNA repair via Abl and Rad51 Cancer Res 68 14 2008 5769 5777
-
(2008)
Cancer Res
, vol.68
, Issue.14
, pp. 5769-5777
-
-
Ganapathipillai, S.S.1
Medova, M.2
Aebersold, D.M.3
Manley, P.W.4
Berthou, S.5
Streit, B.6
-
53
-
-
77953912455
-
The IGFR1 inhibitor NVP-AEW541 disrupts a pro-survival and pro-angiogenic IGF-STAT3-HIF1 pathway in human glioblastoma cells
-
M.B. Gariboldi, R. Ravizza, and E. Monti The IGFR1 inhibitor NVP-AEW541 disrupts a pro-survival and pro-angiogenic IGF-STAT3-HIF1 pathway in human glioblastoma cells Biochem Pharmacol 80 4 2010 455 462
-
(2010)
Biochem Pharmacol
, vol.80
, Issue.4
, pp. 455-462
-
-
Gariboldi, M.B.1
Ravizza, R.2
Monti, E.3
-
54
-
-
84856152266
-
Targeting MET in cancer: Rationale and progress
-
E. Gherardi, W. Birchmeier, C. Birchmeier, and G. Vande Woude Targeting MET in cancer: rationale and progress Nat Rev Cancer 12 2 2012 89 103
-
(2012)
Nat Rev Cancer
, vol.12
, Issue.2
, pp. 89-103
-
-
Gherardi, E.1
Birchmeier, W.2
Birchmeier, C.3
Vande Woude, G.4
-
55
-
-
0032079312
-
Hypoxia stimulates urokinase receptor expression through a heme protein-dependent pathway
-
C.H. Graham, T.E. Fitzpatrick, and K.R. McCrae Hypoxia stimulates urokinase receptor expression through a heme protein-dependent pathway Blood 91 9 1998 3300 3307
-
(1998)
Blood
, vol.91
, Issue.9
, pp. 3300-3307
-
-
Graham, C.H.1
Fitzpatrick, T.E.2
McCrae, K.R.3
-
56
-
-
0242581718
-
Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells
-
L. Gunaratnam, M. Morley, A. Franovic, N. de Paulsen, K. Mekhail, and D.A. Parolin Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells J Biol Chem 278 45 2003 44966 44974
-
(2003)
J Biol Chem
, vol.278
, Issue.45
, pp. 44966-44974
-
-
Gunaratnam, L.1
Morley, M.2
Franovic, A.3
De Paulsen, N.4
Mekhail, K.5
Parolin, D.A.6
-
57
-
-
84860356630
-
Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth
-
P. Hamerlik, J.D. Lathia, R. Rasmussen, Q. Wu, J. Bartkova, and M. Lee Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth J Exp Med 209 3 2012 507 520
-
(2012)
J Exp Med
, vol.209
, Issue.3
, pp. 507-520
-
-
Hamerlik, P.1
Lathia, J.D.2
Rasmussen, R.3
Wu, Q.4
Bartkova, J.5
Lee, M.6
-
58
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 5 2011 646 674
-
(2011)
Cell
, vol.144
, Issue.5
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
59
-
-
11844304072
-
Restraining PI3K: MTOR signalling goes back to the membrane
-
L.S. Harrington, G.M. Findlay, and R.F. Lamb Restraining PI3K: mTOR signalling goes back to the membrane Trends Biochem Sci 30 1 2005 35 42
-
(2005)
Trends Biochem Sci
, vol.30
, Issue.1
, pp. 35-42
-
-
Harrington, L.S.1
Findlay, G.M.2
Lamb, R.F.3
-
60
-
-
0036359548
-
Hypoxia - A key regulatory factor in tumour growth
-
A.L. Harris Hypoxia - a key regulatory factor in tumour growth Nat Rev Cancer 2 1 2002 38 47
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.1
, pp. 38-47
-
-
Harris, A.L.1
-
61
-
-
33750630119
-
Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype
-
L. Holmquist-Mengelbier, E. Fredlund, T. Löfstedt, R. Noguera, S. Navarro, and H. Nilsson Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype Cancer Cell 10 5 2006 413 423
-
(2006)
Cancer Cell
, vol.10
, Issue.5
, pp. 413-423
-
-
Holmquist-Mengelbier, L.1
Fredlund, E.2
Löfstedt, T.3
Noguera, R.4
Navarro, S.5
Nilsson, H.6
-
62
-
-
33751569391
-
Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway
-
T. Ide, Y. Kitajima, A. Miyoshi, T. Ohtsuka, M. Mitsuno, and K. Ohtaka Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway Int J Cancer 119 12 2006 2750 2759
-
(2006)
Int J Cancer
, vol.119
, Issue.12
, pp. 2750-2759
-
-
Ide, T.1
Kitajima, Y.2
Miyoshi, A.3
Ohtsuka, T.4
Mitsuno, M.5
Ohtaka, K.6
-
63
-
-
0029117223
-
Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells
-
E. Ikeda, M.G. Achen, G. Breier, and W. Risau Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells J Biol Chem 270 34 1995 19761 19766
-
(1995)
J Biol Chem
, vol.270
, Issue.34
, pp. 19761-19766
-
-
Ikeda, E.1
Achen, M.G.2
Breier, G.3
Risau, W.4
-
64
-
-
0029090338
-
Tumour suppression by the human von Hippel-Lindau gene product
-
O. Iliopoulos, A. Kibel, S. Gray, and W.G. Kaelin Tumour suppression by the human von Hippel-Lindau gene product Nat Med 1 8 1995 822 826
-
(1995)
Nat Med
, vol.1
, Issue.8
, pp. 822-826
-
-
Iliopoulos, O.1
Kibel, A.2
Gray, S.3
Kaelin, W.G.4
-
65
-
-
0033582415
-
Decorin is a biological ligand for the epidermal growth factor receptor
-
R.V. Iozzo, D.K. Moscatello, D.J. McQuillan, and I. Eichstetter Decorin is a biological ligand for the epidermal growth factor receptor J Biol Chem 274 8 1999 4489 4492
-
(1999)
J Biol Chem
, vol.274
, Issue.8
, pp. 4489-4492
-
-
Iozzo, R.V.1
Moscatello, D.K.2
McQuillan, D.J.3
Eichstetter, I.4
-
66
-
-
0030787469
-
Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension
-
B.H. Jiang, J.Z. Zheng, S.W. Leung, R. Roe, and G.L. Semenza Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension J Biol Chem 272 31 1997 19253 19260
-
(1997)
J Biol Chem
, vol.272
, Issue.31
, pp. 19253-19260
-
-
Jiang, B.H.1
Zheng, J.Z.2
Leung, S.W.3
Roe, R.4
Semenza, G.L.5
-
67
-
-
0034925041
-
Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1
-
B.H. Jiang, G. Jiang, J.Z. Zheng, Z. Lu, T. Hunter, and P.K. Vogt Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1 Cell Growth Differ 12 7 2001 363 369
-
(2001)
Cell Growth Differ
, vol.12
, Issue.7
, pp. 363-369
-
-
Jiang, B.H.1
Jiang, G.2
Zheng, J.Z.3
Lu, Z.4
Hunter, T.5
Vogt, P.K.6
-
68
-
-
0347334750
-
IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis
-
Y.J. Jung, J.S. Isaacs, S. Lee, J. Trepel, and L. Neckers IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis FASEB J 17 14 2003 2115 2117
-
(2003)
FASEB J
, vol.17
, Issue.14
, pp. 2115-2117
-
-
Jung, Y.J.1
Isaacs, J.S.2
Lee, S.3
Trepel, J.4
Neckers, L.5
-
69
-
-
33746496671
-
Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1alpha C-terminal activation domain
-
S. Kaluz, M. Kaluzova, and E.J. Stanbridge Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1alpha C-terminal activation domain Mol Cell Biol 26 15 2006 5895 5907
-
(2006)
Mol Cell Biol
, vol.26
, Issue.15
, pp. 5895-5907
-
-
Kaluz, S.1
Kaluzova, M.2
Stanbridge, E.J.3
-
70
-
-
69949173138
-
Silencing of ErbB3/ErbB2 signaling by immunoglobulin-like Necl-2
-
S. Kawano, W. Ikeda, M. Kishimoto, H. Ogita, and Y. Takai Silencing of ErbB3/ErbB2 signaling by immunoglobulin-like Necl-2 J Biol Chem 284 35 2009 23793 23805
-
(2009)
J Biol Chem
, vol.284
, Issue.35
, pp. 23793-23805
-
-
Kawano, S.1
Ikeda, W.2
Kishimoto, M.3
Ogita, H.4
Takai, Y.5
-
71
-
-
84896714836
-
Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer
-
A.A. Kazi, R.A. Gilani, A.J. Schech, S. Chumsri, G. Sabnis, and P. Shah Nonhypoxic regulation and role of hypoxia-inducible factor 1 in aromatase inhibitor resistant breast cancer Breast Cancer Res 16 1 2014 R15
-
(2014)
Breast Cancer Res
, vol.16
, Issue.1
, pp. R15
-
-
Kazi, A.A.1
Gilani, R.A.2
Schech, A.J.3
Chumsri, S.4
Sabnis, G.5
Shah, P.6
-
72
-
-
0031974197
-
Insulin-like growth factor II induced by hypoxia may contribute to angiogenesis of human hepatocellular carcinoma
-
K.W. Kim, S.K. Bae, O.H. Lee, M.H. Bae, M.J. Lee, and B.C. Park Insulin-like growth factor II induced by hypoxia may contribute to angiogenesis of human hepatocellular carcinoma Cancer Res 58 2 1998 348 351
-
(1998)
Cancer Res
, vol.58
, Issue.2
, pp. 348-351
-
-
Kim, K.W.1
Bae, S.K.2
Lee, O.H.3
Bae, M.H.4
Lee, M.J.5
Park, B.C.6
-
73
-
-
84919416478
-
Effects of YC-1 on learning and memory functions of aged rats
-
I. Komsuoglu Celikyurt, T. Utkan, C. Ozer, N. Gacar, and F. Aricioglu Effects of YC-1 on learning and memory functions of aged rats Med Sci Monit Basic Res 20 2014 130 137
-
(2014)
Med Sci Monit Basic Res
, vol.20
, pp. 130-137
-
-
Komsuoglu Celikyurt, I.1
Utkan, T.2
Ozer, C.3
Gacar, N.4
Aricioglu, F.5
-
74
-
-
0034652779
-
Candidate genes for the hypoxic tumor phenotype
-
A.C. Koong, N.C. Denko, K.M. Hudson, C. Schindler, L. Swiersz, and C. Koch Candidate genes for the hypoxic tumor phenotype Cancer Res 60 4 2000 883 887
-
(2000)
Cancer Res
, vol.60
, Issue.4
, pp. 883-887
-
-
Koong, A.C.1
Denko, N.C.2
Hudson, K.M.3
Schindler, C.4
Swiersz, L.5
Koch, C.6
-
75
-
-
79960989122
-
Multihistology: Target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1α in advanced solid tumors
-
S. Kummar, M. Raffeld, L. Juwara, Y. Horneffer, A. Strassberger, and D. Allen Multihistology: target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1α in advanced solid tumors Clin Cancer Res 17 15 2011 5123 5131
-
(2011)
Clin Cancer Res
, vol.17
, Issue.15
, pp. 5123-5131
-
-
Kummar, S.1
Raffeld, M.2
Juwara, L.3
Horneffer, Y.4
Strassberger, A.5
Allen, D.6
-
76
-
-
72849127628
-
Kinase mutations in human disease: Interpreting genotype-phenotype relationships
-
P. Lahiry, A. Torkamani, N.J. Schork, and R.A. Hegele Kinase mutations in human disease: interpreting genotype-phenotype relationships Nat Rev Genet 11 1 2010 60 74
-
(2010)
Nat Rev Genet
, vol.11
, Issue.1
, pp. 60-74
-
-
Lahiry, P.1
Torkamani, A.2
Schork, N.J.3
Hegele, R.A.4
-
77
-
-
0035812284
-
Transcriptional response to hypoxia in human tumors
-
A. Lal, H. Peters, B. St Croix, Z.A. Haroon, M.W. Dewhirst, and R.L. Strausberg Transcriptional response to hypoxia in human tumors J Natl Cancer Inst 93 17 2001 1337 1343
-
(2001)
J Natl Cancer Inst
, vol.93
, Issue.17
, pp. 1337-1343
-
-
Lal, A.1
Peters, H.2
St Croix, B.3
Haroon, Z.A.4
Dewhirst, M.W.5
Strausberg, R.L.6
-
78
-
-
0035012605
-
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
E. Laughner, P. Taghavi, K. Chiles, P.C. Mahon, and G.L. Semenza HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression Mol Cell Biol 21 12 2001 3995 4004
-
(2001)
Mol Cell Biol
, vol.21
, Issue.12
, pp. 3995-4004
-
-
Laughner, E.1
Taghavi, P.2
Chiles, K.3
Mahon, P.C.4
Semenza, G.L.5
-
79
-
-
84905392051
-
Synergistic signaling of tumor cell invasiveness by hepatocyte growth factor and hypoxia
-
Y.H. Lee, B.L. Morrison, and D.P. Bottaro Synergistic signaling of tumor cell invasiveness by hepatocyte growth factor and hypoxia J Biol Chem 289 30 2014 20448 20461
-
(2014)
J Biol Chem
, vol.289
, Issue.30
, pp. 20448-20461
-
-
Lee, Y.H.1
Morrison, B.L.2
Bottaro, D.P.3
-
80
-
-
77953896432
-
Cell signaling by receptor tyrosine kinases
-
M.A. Lemmon, and J. Schlessinger Cell signaling by receptor tyrosine kinases Cell 141 7 2010 1117 1134
-
(2010)
Cell
, vol.141
, Issue.7
, pp. 1117-1134
-
-
Lemmon, M.A.1
Schlessinger, J.2
-
81
-
-
84897687361
-
Combined treatment with sodium butyrate and PD153035 enhances keratinocyte differentiation
-
S. Leon Carrion, C.H. Sutter, and T.R. Sutter Combined treatment with sodium butyrate and PD153035 enhances keratinocyte differentiation Exp Dermatol 23 3 2014 211 214
-
(2014)
Exp Dermatol
, vol.23
, Issue.3
, pp. 211-214
-
-
Leon Carrion, S.1
Sutter, C.H.2
Sutter, T.R.3
-
82
-
-
34547868882
-
Ron-receptor tyrosine kinase in tumorigenesis and metastasis
-
M.A. Leonis, M.N. Thobe, and S.E. Waltz Ron-receptor tyrosine kinase in tumorigenesis and metastasis Future Oncol 3 4 2007 441 448
-
(2007)
Future Oncol
, vol.3
, Issue.4
, pp. 441-448
-
-
Leonis, M.A.1
Thobe, M.N.2
Waltz, S.E.3
-
83
-
-
0030044039
-
Post-transcriptional regulation of vascular endothelial growth factor by hypoxia
-
A.P. Levy, N.S. Levy, and M.A. Goldberg Post-transcriptional regulation of vascular endothelial growth factor by hypoxia J Biol Chem 271 5 1996 2746 2753
-
(1996)
J Biol Chem
, vol.271
, Issue.5
, pp. 2746-2753
-
-
Levy, A.P.1
Levy, N.S.2
Goldberg, M.A.3
-
84
-
-
0031900740
-
Signal transduction through MAP kinase cascades
-
T.S. Lewis, P.S. Shapiro, and N.G. Ahn Signal transduction through MAP kinase cascades Adv Cancer Res 74 1998 49 139
-
(1998)
Adv Cancer Res
, vol.74
, pp. 49-139
-
-
Lewis, T.S.1
Shapiro, P.S.2
Ahn, N.G.3
-
85
-
-
79960989834
-
Stem cell quiescence
-
L. Li, and R. Bhatia Stem cell quiescence Clin Cancer Res 17 15 2011 4936 4941
-
(2011)
Clin Cancer Res
, vol.17
, Issue.15
, pp. 4936-4941
-
-
Li, L.1
Bhatia, R.2
-
86
-
-
17144372970
-
A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells
-
Y.M. Li, B.P. Zhou, J. Deng, Y. Pan, N. Hay, and M.C. Hung A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells Cancer Res 65 8 2005 3257 3263
-
(2005)
Cancer Res
, vol.65
, Issue.8
, pp. 3257-3263
-
-
Li, Y.M.1
Zhou, B.P.2
Deng, J.3
Pan, Y.4
Hay, N.5
Hung, M.C.6
-
87
-
-
77954414428
-
Impact of the hypoxic tumor microenvironment on the regulation of cancer stem cell characteristics
-
Q. Lin, and Z. Yun Impact of the hypoxic tumor microenvironment on the regulation of cancer stem cell characteristics Cancer Biol Ther 9 12 2010 949 956
-
(2010)
Cancer Biol Ther
, vol.9
, Issue.12
, pp. 949-956
-
-
Lin, Q.1
Yun, Z.2
-
88
-
-
0028887421
-
Identification of the von Hippel-Lindau (VHL) gene. Its role in renal cancer
-
W.M. Linehan, M.I. Lerman, and B. Zbar Identification of the von Hippel-Lindau (VHL) gene. Its role in renal cancer JAMA 273 7 1995 564 570
-
(1995)
JAMA
, vol.273
, Issue.7
, pp. 564-570
-
-
Linehan, W.M.1
Lerman, M.I.2
Zbar, B.3
-
89
-
-
46449103344
-
TAM receptor tyrosine kinases: Biologic functions, signaling, and potential therapeutic targeting in human cancer
-
R.M. Linger, A.K. Keating, H.S. Earp, and D.K. Graham TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer Adv Cancer Res 100 2008 35 83
-
(2008)
Adv Cancer Res
, vol.100
, pp. 35-83
-
-
Linger, R.M.1
Keating, A.K.2
Earp, H.S.3
Graham, D.K.4
-
90
-
-
33846254999
-
RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha
-
Y.V. Liu, J.H. Baek, H. Zhang, R. Diez, R.N. Cole, and G.L. Semenza RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha Mol Cell 25 2 2007 207 217
-
(2007)
Mol Cell
, vol.25
, Issue.2
, pp. 207-217
-
-
Liu, Y.V.1
Baek, J.H.2
Zhang, H.3
Diez, R.4
Cole, R.N.5
Semenza, G.L.6
-
91
-
-
2942724235
-
MTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
-
P.K. Majumder, P.G. Febbo, R. Bikoff, R. Berger, Q. Xue, and L.M. McMahon mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways Nat Med 10 6 2004 594 601
-
(2004)
Nat Med
, vol.10
, Issue.6
, pp. 594-601
-
-
Majumder, P.K.1
Febbo, P.G.2
Bikoff, R.3
Berger, R.4
Xue, Q.5
McMahon, L.M.6
-
92
-
-
79952819549
-
MET inhibition results in DNA breaks and synergistically sensitizes tumor cells to DNA-damaging agents potentially by breaching a damage-induced checkpoint arrest
-
M. Medova, D.M. Aebersold, W. Blank-Liss, B. Streit, M. Medo, and S. Aebi MET inhibition results in DNA breaks and synergistically sensitizes tumor cells to DNA-damaging agents potentially by breaching a damage-induced checkpoint arrest Genes Cancer 1 10 2010 1053 1062
-
(2010)
Genes Cancer
, vol.1
, Issue.10
, pp. 1053-1062
-
-
Medova, M.1
Aebersold, D.M.2
Blank-Liss, W.3
Streit, B.4
Medo, M.5
Aebi, S.6
-
93
-
-
82255163062
-
MET inhibition in tumor cells by PHA665752 impairs homologous recombination repair of DNA double strand breaks
-
M. Medova, D.M. Aebersold, and Y. Zimmer MET inhibition in tumor cells by PHA665752 impairs homologous recombination repair of DNA double strand breaks Int J Cancer 130 3 2012 728 734
-
(2012)
Int J Cancer
, vol.130
, Issue.3
, pp. 728-734
-
-
Medova, M.1
Aebersold, D.M.2
Zimmer, Y.3
-
94
-
-
20444436381
-
Cancer genomics: Small RNAs with big impacts
-
P.S. Meltzer Cancer genomics: small RNAs with big impacts Nature 435 7043 2005 745 746
-
(2005)
Nature
, vol.435
, Issue.7043
, pp. 745-746
-
-
Meltzer, P.S.1
-
95
-
-
1242272855
-
Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin
-
A.M. Mercurio, R.E. Bachelder, R.C. Bates, and J. Chung Autocrine signaling in carcinoma: VEGF and the alpha6beta4 integrin Semin Cancer Biol 14 2 2004 115 122
-
(2004)
Semin Cancer Biol
, vol.14
, Issue.2
, pp. 115-122
-
-
Mercurio, A.M.1
Bachelder, R.E.2
Bates, R.C.3
Chung, J.4
-
96
-
-
70350244837
-
Hypoxia, angiogenesis and cancer therapy: To breathe or not to breathe?
-
P. Michieli Hypoxia, angiogenesis and cancer therapy: to breathe or not to breathe? Cell Cycle 8 20 2009 3291 3296
-
(2009)
Cell Cycle
, vol.8
, Issue.20
, pp. 3291-3296
-
-
Michieli, P.1
-
97
-
-
34548306962
-
Cardiotonic steroids on the road to anti-cancer therapy
-
T. Mijatovic, E. Van Quaquebeke, B. Delest, O. Debeir, F. Darro, and R. Kiss Cardiotonic steroids on the road to anti-cancer therapy Biochim Biophys Acta 1776 1 2007 32 57
-
(2007)
Biochim Biophys Acta
, vol.1776
, Issue.1
, pp. 32-57
-
-
Mijatovic, T.1
Van Quaquebeke, E.2
Delest, B.3
Debeir, O.4
Darro, F.5
Kiss, R.6
-
98
-
-
84862555781
-
Hypoxia stabilizes GAS6/Axl signaling in metastatic prostate cancer
-
A. Mishra, J. Wang, Y. Shiozawa, S. McGee, J. Kim, and Y. Jung Hypoxia stabilizes GAS6/Axl signaling in metastatic prostate cancer Mol Cancer Res 10 6 2012 703 712
-
(2012)
Mol Cancer Res
, vol.10
, Issue.6
, pp. 703-712
-
-
Mishra, A.1
Wang, J.2
Shiozawa, Y.3
McGee, S.4
Kim, J.5
Jung, Y.6
-
99
-
-
38749122031
-
The effect of hypoxic microenvironment on matrix metalloproteinase expression in xenografts of human oral squamous cell carcinoma
-
Y. Miyazaki, A. Hara, K. Kato, T. Oyama, Y. Yamada, and H. Mori The effect of hypoxic microenvironment on matrix metalloproteinase expression in xenografts of human oral squamous cell carcinoma Int J Oncol 32 1 2008 145 151
-
(2008)
Int J Oncol
, vol.32
, Issue.1
, pp. 145-151
-
-
Miyazaki, Y.1
Hara, A.2
Kato, K.3
Oyama, T.4
Yamada, Y.5
Mori, H.6
-
100
-
-
57649231823
-
Therapeutic strategy targeting the mTOR-HIF-1alpha-VEGF pathway in ovarian clear cell adenocarcinoma
-
M. Miyazawa, M. Yasuda, M. Fujita, H. Kajiwara, K. Hirabayashi, and S. Takekoshi Therapeutic strategy targeting the mTOR-HIF-1alpha-VEGF pathway in ovarian clear cell adenocarcinoma Pathol Int 59 1 2009 19 27
-
(2009)
Pathol Int
, vol.59
, Issue.1
, pp. 19-27
-
-
Miyazawa, M.1
Yasuda, M.2
Fujita, M.3
Kajiwara, H.4
Hirabayashi, K.5
Takekoshi, S.6
-
101
-
-
2342611976
-
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules
-
B.J. Moeller, Y. Cao, C.Y. Li, and M.W. Dewhirst Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules Cancer Cell 5 5 2004 429 441
-
(2004)
Cancer Cell
, vol.5
, Issue.5
, pp. 429-441
-
-
Moeller, B.J.1
Cao, Y.2
Li, C.Y.3
Dewhirst, M.W.4
-
102
-
-
84874204327
-
MiR-214 and hypoxia down-regulate Necl-2/CADM1 and enhance ErbB2/ErbB3 signaling
-
K. Momose, A. Minami, Y. Shimono, K. Mizutani, K. Nobutani, and T. Azuma miR-214 and hypoxia down-regulate Necl-2/CADM1 and enhance ErbB2/ErbB3 signaling Genes Cells 18 3 2013 195 202
-
(2013)
Genes Cells
, vol.18
, Issue.3
, pp. 195-202
-
-
Momose, K.1
Minami, A.2
Shimono, Y.3
Mizutani, K.4
Nobutani, K.5
Azuma, T.6
-
103
-
-
0032518407
-
Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor
-
D.K. Moscatello, M. Santra, D.M. Mann, D.J. McQuillan, A.J. Wong, and R.V. Iozzo Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor J Clin Investig 101 2 1998 406 412
-
(1998)
J Clin Investig
, vol.101
, Issue.2
, pp. 406-412
-
-
Moscatello, D.K.1
Santra, M.2
Mann, D.M.3
McQuillan, D.J.4
Wong, A.J.5
Iozzo, R.V.6
-
104
-
-
0029068339
-
Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation
-
D. Mukhopadhyay, L. Tsiokas, X.M. Zhou, D. Foster, J.S. Brugge, and V.P. Sukhatme Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation Nature 375 6532 1995 577 581
-
(1995)
Nature
, vol.375
, Issue.6532
, pp. 577-581
-
-
Mukhopadhyay, D.1
Tsiokas, L.2
Zhou, X.M.3
Foster, D.4
Brugge, J.S.5
Sukhatme, V.P.6
-
105
-
-
84898869357
-
Critical role of aberrant angiogenesis in the development of tumor hypoxia and associated radioresistance
-
G. Multhoff, J. Radons, and P. Vaupel Critical role of aberrant angiogenesis in the development of tumor hypoxia and associated radioresistance Cancers (Basel) 6 2 2014 813 828
-
(2014)
Cancers (Basel)
, vol.6
, Issue.2
, pp. 813-828
-
-
Multhoff, G.1
Radons, J.2
Vaupel, P.3
-
106
-
-
27144524031
-
Involvement of a cell adhesion molecule: TSLC1/IGSF4, in human oncogenesis
-
Y. Murakami Involvement of a cell adhesion molecule: TSLC1/IGSF4, in human oncogenesis Cancer Sci 96 9 2005 543 552
-
(2005)
Cancer Sci
, vol.96
, Issue.9
, pp. 543-552
-
-
Murakami, Y.1
-
107
-
-
84900297049
-
Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor
-
A. Murakami, F. Takahashi, F. Nurwidya, I. Kobayashi, K. Minakata, and M. Hashimoto Hypoxia increases gefitinib-resistant lung cancer stem cells through the activation of insulin-like growth factor 1 receptor PLOS ONE 9 1 2014 e86459
-
(2014)
PLOS ONE
, vol.9
, Issue.1
, pp. e86459
-
-
Murakami, A.1
Takahashi, F.2
Nurwidya, F.3
Kobayashi, I.4
Minakata, K.5
Hashimoto, M.6
-
108
-
-
0027077443
-
Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor
-
L. Naldini, L. Tamagnone, E. Vigna, M. Sachs, G. Hartmann, and W. Birchmeier Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor EMBO J 11 13 1992 4825 4833
-
(1992)
EMBO J
, vol.11
, Issue.13
, pp. 4825-4833
-
-
Naldini, L.1
Tamagnone, L.2
Vigna, E.3
Sachs, M.4
Hartmann, G.5
Birchmeier, W.6
-
109
-
-
84857308088
-
Decorin antagonizes the angiogenic network: Concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3
-
T. Neill, H. Painter, S. Buraschi, R.T. Owens, M.P. Lisanti, and L. Schaefer Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3 J Biol Chem 287 8 2012 5492 5506
-
(2012)
J Biol Chem
, vol.287
, Issue.8
, pp. 5492-5506
-
-
Neill, T.1
Painter, H.2
Buraschi, S.3
Owens, R.T.4
Lisanti, M.P.5
Schaefer, L.6
-
110
-
-
40849124038
-
Cardiac glycosides as novel cancer therapeutic agents
-
R.A. Newman, P. Yang, A.D. Pawlus, and K.I. Block Cardiac glycosides as novel cancer therapeutic agents Mol Interv 8 1 2008 36 49
-
(2008)
Mol Interv
, vol.8
, Issue.1
, pp. 36-49
-
-
Newman, R.A.1
Yang, P.2
Pawlus, A.D.3
Block, K.I.4
-
111
-
-
84885816283
-
Bypass mechanisms of resistance to receptor tyrosine kinase inhibition in lung cancer
-
M.J. Niederst, and J.A. Engelman Bypass mechanisms of resistance to receptor tyrosine kinase inhibition in lung cancer Sci Signal 6 294 2013 re6
-
(2013)
Sci Signal
, vol.6
, Issue.294
, pp. re6
-
-
Niederst, M.J.1
Engelman, J.A.2
-
112
-
-
77952671059
-
Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: Implications for antiangiogenic mechanisms of multikinase inhibitors
-
M.B. Nilsson, P.E. Zage, L. Zeng, L. Xu, T. Cascone, and H.K. Wu Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors Oncogene 29 20 2010 2938 2949
-
(2010)
Oncogene
, vol.29
, Issue.20
, pp. 2938-2949
-
-
Nilsson, M.B.1
Zage, P.E.2
Zeng, L.3
Xu, L.4
Cascone, T.5
Wu, H.K.6
-
113
-
-
84858992743
-
Interaction with ErbB4 promotes hypoxia-inducible factor-1alpha signaling
-
I. Paatero, A. Jokilammi, P.T. Heikkinen, K. Iljin, O.P. Kallioniemi, and F.E. Jones Interaction with ErbB4 promotes hypoxia-inducible factor-1alpha signaling J Biol Chem 287 13 2012 9659 9671
-
(2012)
J Biol Chem
, vol.287
, Issue.13
, pp. 9659-9671
-
-
Paatero, I.1
Jokilammi, A.2
Heikkinen, P.T.3
Iljin, K.4
Kallioniemi, O.P.5
Jones, F.E.6
-
114
-
-
84905858377
-
Hypoxia-inducible factor-1α induces ErbB4 signaling in the differentiating mammary gland
-
I. Paatero, T.N. Seagroves, K. Vaparanta, W. Han, F.E. Jones, and R.S. Johnson Hypoxia-inducible factor-1α induces ErbB4 signaling in the differentiating mammary gland J Biol Chem 289 32 2014 22459 22469
-
(2014)
J Biol Chem
, vol.289
, Issue.32
, pp. 22459-22469
-
-
Paatero, I.1
Seagroves, T.N.2
Vaparanta, K.3
Han, W.4
Jones, F.E.5
Johnson, R.S.6
-
115
-
-
84905858377
-
Hypoxia-inducible factor-1alpha induces ErbB4 signaling in the differentiating mammary gland
-
I. Paatero, T.N. Seagroves, K. Vaparanta, W. Han, F.E. Jones, and R.S. Johnson Hypoxia-inducible factor-1alpha induces ErbB4 signaling in the differentiating mammary gland J Biol Chem 289 32 2014 22459 22469
-
(2014)
J Biol Chem
, vol.289
, Issue.32
, pp. 22459-22469
-
-
Paatero, I.1
Seagroves, T.N.2
Vaparanta, K.3
Han, W.4
Jones, F.E.5
Johnson, R.S.6
-
116
-
-
33847181297
-
The multiple faces of caveolae
-
R.G. Parton, and K. Simons The multiple faces of caveolae Nat Rev Mol Cell Biol 8 3 2007 185 194
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, Issue.3
, pp. 185-194
-
-
Parton, R.G.1
Simons, K.2
-
117
-
-
0028111173
-
Cloning and characterization of MN: A human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment
-
J. Pastorek, S. Pastorekova, I. Callebaut, J.P. Mornon, V. Zelnik, and R. Opavsky Cloning and characterization of MN: a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment Oncogene 9 10 1994 2877 2888
-
(1994)
Oncogene
, vol.9
, Issue.10
, pp. 2877-2888
-
-
Pastorek, J.1
Pastorekova, S.2
Callebaut, I.3
Mornon, J.P.4
Zelnik, V.5
Opavsky, R.6
-
118
-
-
33646135276
-
Tyrosine kinase - Role and significance in Cancer
-
M.K. Paul, and A.K. Mukhopadhyay Tyrosine kinase - role and significance in Cancer Int J Med Sci 1 2 2004 101 115
-
(2004)
Int J Med Sci
, vol.1
, Issue.2
, pp. 101-115
-
-
Paul, M.K.1
Mukhopadhyay, A.K.2
-
119
-
-
0032445260
-
HER-2/neu as a predictive marker of response to breast cancer therapy
-
M.D. Pegram, G. Pauletti, and D.J. Slamon HER-2/neu as a predictive marker of response to breast cancer therapy Breast Cancer Res Treat 52 1-3 1998 65 77
-
(1998)
Breast Cancer Res Treat
, vol.52
, Issue.13
, pp. 65-77
-
-
Pegram, M.D.1
Pauletti, G.2
Slamon, D.J.3
-
120
-
-
33748742635
-
Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression
-
X.H. Peng, P. Karna, Z. Cao, B.H. Jiang, M. Zhou, and L. Yang Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression J Biol Chem 281 36 2006 25903 25914
-
(2006)
J Biol Chem
, vol.281
, Issue.36
, pp. 25903-25914
-
-
Peng, X.H.1
Karna, P.2
Cao, Z.3
Jiang, B.H.4
Zhou, M.5
Yang, L.6
-
121
-
-
0037478437
-
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
-
S. Pennacchietti, P. Michieli, M. Galluzzo, M. Mazzone, S. Giordano, and P.M. Comoglio Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene Cancer Cell 3 4 2003 347 361
-
(2003)
Cancer Cell
, vol.3
, Issue.4
, pp. 347-361
-
-
Pennacchietti, S.1
Michieli, P.2
Galluzzo, M.3
Mazzone, M.4
Giordano, S.5
Comoglio, P.M.6
-
122
-
-
0001223491
-
Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
-
A.M. Petit, J. Rak, M.C. Hung, P. Rockwell, N. Goldstein, and B. Fendly Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors Am J Pathol 151 6 1997 1523 1530
-
(1997)
Am J Pathol
, vol.151
, Issue.6
, pp. 1523-1530
-
-
Petit, A.M.1
Rak, J.2
Hung, M.C.3
Rockwell, P.4
Goldstein, N.5
Fendly, B.6
-
123
-
-
0033203243
-
Motivating endosome motility
-
S.R. Pfeffer Motivating endosome motility Nat Cell Biol 1 6 1999 E145 E147
-
(1999)
Nat Cell Biol
, vol.1
, Issue.6
, pp. E145-E147
-
-
Pfeffer, S.R.1
-
124
-
-
20444445920
-
Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha
-
R.J. Phillips, J. Mestas, M. Gharaee-Kermani, M.D. Burdick, A. Sica, and J.A. Belperio Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha J Biol Chem 280 23 2005 22473 22481
-
(2005)
J Biol Chem
, vol.280
, Issue.23
, pp. 22473-22481
-
-
Phillips, R.J.1
Mestas, J.2
Gharaee-Kermani, M.3
Burdick, M.D.4
Sica, A.5
Belperio, J.A.6
-
125
-
-
84890794931
-
TAM receptor tyrosine kinases: Expression, disease and oncogenesis in the central nervous system
-
A.M. Pierce, and A.K. Keating TAM receptor tyrosine kinases: expression, disease and oncogenesis in the central nervous system Brain Res 1542 2014 206 220
-
(2014)
Brain Res
, vol.1542
, pp. 206-220
-
-
Pierce, A.M.1
Keating, A.K.2
-
126
-
-
0026520193
-
Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis
-
S.J. Pilkis, and D.K. Granner Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis Annu Rev Physiol 54 1992 885 909
-
(1992)
Annu Rev Physiol
, vol.54
, pp. 885-909
-
-
Pilkis, S.J.1
Granner, D.K.2
-
127
-
-
33846277696
-
Repression of protein synthesis by miRNAs: How many mechanisms?
-
R.S. Pillai, S.N. Bhattacharyya, and W. Filipowicz Repression of protein synthesis by miRNAs: how many mechanisms? Trends Cell Biol 17 3 2007 118 126
-
(2007)
Trends Cell Biol
, vol.17
, Issue.3
, pp. 118-126
-
-
Pillai, R.S.1
Bhattacharyya, S.N.2
Filipowicz, W.3
-
128
-
-
33645499486
-
EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms
-
N. Pore, Z. Jiang, A. Gupta, G. Cerniglia, G.D. Kao, and A. Maity EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms Cancer Res 66 6 2006 3197 3204
-
(2006)
Cancer Res
, vol.66
, Issue.6
, pp. 3197-3204
-
-
Pore, N.1
Jiang, Z.2
Gupta, A.3
Cerniglia, G.4
Kao, G.D.5
Maity, A.6
-
129
-
-
0032407024
-
Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografts in nude mice
-
M. Prewett, M. Rothman, H. Waksal, M. Feldman, N.H. Bander, and D.J. Hicklin Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografts in nude mice Clin Cancer Res 4 12 1998 2957 2966
-
(1998)
Clin Cancer Res
, vol.4
, Issue.12
, pp. 2957-2966
-
-
Prewett, M.1
Rothman, M.2
Waksal, H.3
Feldman, M.4
Bander, N.H.5
Hicklin, D.J.6
-
130
-
-
59649092634
-
Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62
-
J.P. Pursiheimo, K. Rantanen, P.T. Heikkinen, T. Johansen, and P.M. Jaakkola Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62 Oncogene 28 3 2009 334 344
-
(2009)
Oncogene
, vol.28
, Issue.3
, pp. 334-344
-
-
Pursiheimo, J.P.1
Rantanen, K.2
Heikkinen, P.T.3
Johansen, T.4
Jaakkola, P.M.5
-
131
-
-
84907192193
-
Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET
-
E.B. Rankin, K.C. Fuh, L. Castellini, K. Viswanathan, E.C. Finger, and A.N. Diep Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET Proc Natl Acad Sci USA 111 37 2014 13373 13378
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, Issue.37
, pp. 13373-13378
-
-
Rankin, E.B.1
Fuh, K.C.2
Castellini, L.3
Viswanathan, K.4
Finger, E.C.5
Diep, A.N.6
-
132
-
-
0036682284
-
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
-
A. Rapisarda, B. Uranchimeg, D.A. Scudiero, M. Selby, E.A. Sausville, and R.H. Shoemaker Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway Cancer Res 62 15 2002 4316 4324
-
(2002)
Cancer Res
, vol.62
, Issue.15
, pp. 4316-4324
-
-
Rapisarda, A.1
Uranchimeg, B.2
Scudiero, D.A.3
Selby, M.4
Sausville, E.A.5
Shoemaker, R.H.6
-
133
-
-
0034282388
-
Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells
-
D.E. Richard, E. Berra, and J. Pouyssegur Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells J Biol Chem 275 35 2000 26765 26771
-
(2000)
J Biol Chem
, vol.275
, Issue.35
, pp. 26765-26771
-
-
Richard, D.E.1
Berra, E.2
Pouyssegur, J.3
-
134
-
-
0025781290
-
Prognostic significance of HER-2/neu expression in breast cancer and its relationship to other prognostic factors
-
F. Rilke, M.I. Colnaghi, N. Cascinelli, S. Andreola, M.T. Baldini, and R. Bufalino Prognostic significance of HER-2/neu expression in breast cancer and its relationship to other prognostic factors Int J Cancer 49 1 1991 44 49
-
(1991)
Int J Cancer
, vol.49
, Issue.1
, pp. 44-49
-
-
Rilke, F.1
Colnaghi, M.I.2
Cascinelli, N.3
Andreola, S.4
Baldini, M.T.5
Bufalino, R.6
-
135
-
-
84858005733
-
Acquired resistance to drugs targeting receptor tyrosine kinases
-
S.A. Rosenzweig Acquired resistance to drugs targeting receptor tyrosine kinases Biochem Pharmacol 83 8 2012 1041 1048
-
(2012)
Biochem Pharmacol
, vol.83
, Issue.8
, pp. 1041-1048
-
-
Rosenzweig, S.A.1
-
136
-
-
68049105076
-
Role of hypoxia in the hallmarks of human cancer
-
K. Ruan, G. Song, and G. Ouyang Role of hypoxia in the hallmarks of human cancer J Cell Biochem 107 6 2009 1053 1062
-
(2009)
J Cell Biochem
, vol.107
, Issue.6
, pp. 1053-1062
-
-
Ruan, K.1
Song, G.2
Ouyang, G.3
-
137
-
-
79960264282
-
Adaptive changes results in activation of alternate signaling pathways and resistance to aromatase inhibitor resistance
-
G. Sabnis, and A. Brodie Adaptive changes results in activation of alternate signaling pathways and resistance to aromatase inhibitor resistance Mol Cell Endocrinol 340 2 2011 142 147
-
(2011)
Mol Cell Endocrinol
, vol.340
, Issue.2
, pp. 142-147
-
-
Sabnis, G.1
Brodie, A.2
-
138
-
-
2342486598
-
Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways
-
S.C. Santos, and S. Dias Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways Blood 103 10 2004 3883 3889
-
(2004)
Blood
, vol.103
, Issue.10
, pp. 3883-3889
-
-
Santos, S.C.1
Dias, S.2
-
139
-
-
0034634669
-
An anti-oncogenic role for decorin. Down-regulation of ErbB2 leads to growth suppression and cytodifferentiation of mammary carcinoma cells
-
M. Santra, I. Eichstetter, and R.V. Iozzo An anti-oncogenic role for decorin. Down-regulation of ErbB2 leads to growth suppression and cytodifferentiation of mammary carcinoma cells J Biol Chem 275 45 2000 35153 35161
-
(2000)
J Biol Chem
, vol.275
, Issue.45
, pp. 35153-35161
-
-
Santra, M.1
Eichstetter, I.2
Iozzo, R.V.3
-
140
-
-
84867087464
-
Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells
-
L. Schito, S. Rey, M. Tafani, H. Zhang, C.C. Wong, and A. Russo Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells Proc Natl Acad Sci USA 109 40 2012 E2707 E2716
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.40
, pp. E2707-E2716
-
-
Schito, L.1
Rey, S.2
Tafani, M.3
Zhang, H.4
Wong, C.C.5
Russo, A.6
-
141
-
-
0032787281
-
Tissue microarrays for gene amplification surveys in many different tumor types
-
P. Schraml, J. Kononen, L. Bubendorf, H. Moch, H. Bissig, and A. Nocito Tissue microarrays for gene amplification surveys in many different tumor types Clin Cancer Res 5 8 1999 1966 1975
-
(1999)
Clin Cancer Res
, vol.5
, Issue.8
, pp. 1966-1975
-
-
Schraml, P.1
Kononen, J.2
Bubendorf, L.3
Moch, H.4
Bissig, H.5
Nocito, A.6
-
142
-
-
65349105926
-
Increase in gene dosage is a mechanism of HIF-1alpha constitutive expression in head and neck squamous cell carcinomas
-
P. Secades, J.P. Rodrigo, M. Hermsen, C. Alvarez, C. Suarez, and M.D. Chiara Increase in gene dosage is a mechanism of HIF-1alpha constitutive expression in head and neck squamous cell carcinomas Genes Chromosomes Cancer 48 5 2009 441 454
-
(2009)
Genes Chromosomes Cancer
, vol.48
, Issue.5
, pp. 441-454
-
-
Secades, P.1
Rodrigo, J.P.2
Hermsen, M.3
Alvarez, C.4
Suarez, C.5
Chiara, M.D.6
-
143
-
-
84948568744
-
In vitro study of normoxic epidermal growth factor receptor-induced hypoxia-inducible factor-1-alpha, vascular endothelial growth factor, and BNIP3 expression in head and neck squamous cell carcinoma cell lines: Implications for anti-epidermal growth factor receptor therapy
-
P. Secades, I.S. de Santa-María, A. Merlo, C. Suarez, and M.D. Chiara In vitro study of normoxic epidermal growth factor receptor-induced hypoxia-inducible factor-1-alpha, vascular endothelial growth factor, and BNIP3 expression in head and neck squamous cell carcinoma cell lines: implications for anti-epidermal growth factor receptor therapy Head Neck 2014 10.1002/hed.23733
-
(2014)
Head Neck
-
-
Secades, P.1
De Santa-María, I.S.2
Merlo, A.3
Suarez, C.4
Chiara, M.D.5
-
144
-
-
0032190614
-
Hypoxia-inducible factor 1: Master regulator of O2 homeostasis
-
G.L. Semenza Hypoxia-inducible factor 1: master regulator of O2 homeostasis Curr Opin Genet Dev 8 5 1998 588 594
-
(1998)
Curr Opin Genet Dev
, vol.8
, Issue.5
, pp. 588-594
-
-
Semenza, G.L.1
-
145
-
-
0035812772
-
HIF-1, O(2), and the 3 PHDs: How animal cells signal hypoxia to the nucleus
-
G.L. Semenza HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus Cell 107 1 2001 1 3
-
(2001)
Cell
, vol.107
, Issue.1
, pp. 1-3
-
-
Semenza, G.L.1
-
146
-
-
84859445000
-
Hypoxia-inducible factors: Mediators of cancer progression and targets for cancer therapy
-
G.L. Semenza Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy Trends Pharmacol Sci 33 4 2012 207 214
-
(2012)
Trends Pharmacol Sci
, vol.33
, Issue.4
, pp. 207-214
-
-
Semenza, G.L.1
-
147
-
-
77953319433
-
Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation: Role of Krebs cycle metabolites
-
A. Serra-Pérez, A.M. Planas, A. Núñez-O'Mara, E. Berra, J. García-Villoria, and A. Ribes Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation: role of Krebs cycle metabolites J Biol Chem 285 24 2010 18217 18224
-
(2010)
J Biol Chem
, vol.285
, Issue.24
, pp. 18217-18224
-
-
Serra-Pérez, A.1
Planas, A.M.2
Núñez-O'Mara, A.3
Berra, E.4
García-Villoria, J.5
Ribes, A.6
-
148
-
-
40249103622
-
Hypoxia-induced epithelial VEGF-C/VEGFR-3 upregulation in carcinoma cell lines
-
N. Simiantonaki, C. Jayasinghe, R. Michel-Schmidt, K. Peters, M.I. Hermanns, and C.J. Kirkpatrick Hypoxia-induced epithelial VEGF-C/VEGFR-3 upregulation in carcinoma cell lines Int J Oncol 32 3 2008 585 592
-
(2008)
Int J Oncol
, vol.32
, Issue.3
, pp. 585-592
-
-
Simiantonaki, N.1
Jayasinghe, C.2
Michel-Schmidt, R.3
Peters, K.4
Hermanns, M.I.5
Kirkpatrick, C.J.6
-
149
-
-
31544470131
-
Activation of RhoB by hypoxia controls hypoxia-inducible factor-1alpha stabilization through glycogen synthase kinase-3 in U87 glioblastoma cells
-
N. Skuli, S. Monferran, C. Delmas, I. Lajoie-Mazenc, G. Favre, and C. Toulas Activation of RhoB by hypoxia controls hypoxia-inducible factor-1alpha stabilization through glycogen synthase kinase-3 in U87 glioblastoma cells Cancer Res 66 1 2006 482 489
-
(2006)
Cancer Res
, vol.66
, Issue.1
, pp. 482-489
-
-
Skuli, N.1
Monferran, S.2
Delmas, C.3
Lajoie-Mazenc, I.4
Favre, G.5
Toulas, C.6
-
150
-
-
0029082384
-
Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes
-
I. Stein, M. Neeman, D. Shweiki, A. Itin, and E. Keshet Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes Mol Cell Biol 15 10 1995 5363 5368
-
(1995)
Mol Cell Biol
, vol.15
, Issue.10
, pp. 5363-5368
-
-
Stein, I.1
Neeman, M.2
Shweiki, D.3
Itin, A.4
Keshet, E.5
-
151
-
-
1342329716
-
Autocrine pathways of the vascular endothelial growth factor (VEGF) in glioblastoma multiforme: Clinical relevance of radiation-induced increase of VEGF levels
-
H.H. Steiner, S. Karcher, M.M. Mueller, E. Nalbantis, S. Kunze, and C. Herold-Mende Autocrine pathways of the vascular endothelial growth factor (VEGF) in glioblastoma multiforme: clinical relevance of radiation-induced increase of VEGF levels J Neurooncol 66 1-2 2004 129 138
-
(2004)
J Neurooncol
, vol.66
, Issue.12
, pp. 129-138
-
-
Steiner, H.H.1
Karcher, S.2
Mueller, M.M.3
Nalbantis, E.4
Kunze, S.5
Herold-Mende, C.6
-
152
-
-
77956240797
-
Resistance to mammalian target of rapamycin inhibitor therapy in perivascular epithelioid cell tumors
-
V. Subbiah, J.C. Trent, and R. Kurzrock Resistance to mammalian target of rapamycin inhibitor therapy in perivascular epithelioid cell tumors J Clin Oncol 28 24 2010 e415
-
(2010)
J Clin Oncol
, vol.28
, Issue.24
, pp. e415
-
-
Subbiah, V.1
Trent, J.C.2
Kurzrock, R.3
-
153
-
-
34249982595
-
YC-1 inhibits HIF-1 expression in prostate cancer cells: Contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia
-
H.L. Sun, Y.N. Liu, Y.T. Huang, S.L. Pan, D.Y. Huang, and J.H. Guh YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia Oncogene 26 27 2007 3941 3951
-
(2007)
Oncogene
, vol.26
, Issue.27
, pp. 3941-3951
-
-
Sun, H.L.1
Liu, Y.N.2
Huang, Y.T.3
Pan, S.L.4
Huang, D.Y.5
Guh, J.H.6
-
154
-
-
84910645379
-
Niacin activates the PI3K/Akt cascade via PKC- and EGFR-transactivation-dependent pathways through hydroxyl-carboxylic acid receptor 2
-
H. Sun, G. Li, W. Zhang, Q. Zhou, Y. Yu, and Y. Shi Niacin activates the PI3K/Akt cascade via PKC- and EGFR-transactivation-dependent pathways through hydroxyl-carboxylic acid receptor 2 PLOS ONE 9 11 2014 e112310
-
(2014)
PLOS ONE
, vol.9
, Issue.11
, pp. e112310
-
-
Sun, H.1
Li, G.2
Zhang, W.3
Zhou, Q.4
Yu, Y.5
Shi, Y.6
-
155
-
-
33244491058
-
Interactions between hypoxia and epidermal growth factor receptor in non-small-cell lung cancer
-
D.E. Swinson, and K.J. O'Byrne Interactions between hypoxia and epidermal growth factor receptor in non-small-cell lung cancer Clin Lung Cancer 7 4 2006 250 256
-
(2006)
Clin Lung Cancer
, vol.7
, Issue.4
, pp. 250-256
-
-
Swinson, D.E.1
O'Byrne, K.J.2
-
156
-
-
0034816327
-
Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells
-
L. Tacchini, P. Dansi, E. Matteucci, and M.A. Desiderio Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells Carcinogenesis 22 9 2001 1363 1371
-
(2001)
Carcinogenesis
, vol.22
, Issue.9
, pp. 1363-1371
-
-
Tacchini, L.1
Dansi, P.2
Matteucci, E.3
Desiderio, M.A.4
-
157
-
-
8844286064
-
Hepatocyte growth factor-activated NF-kappaB regulates HIF-1 activity and ODC expression: Implicated in survival, differently in different carcinoma cell lines
-
L. Tacchini, C. De Ponti, E. Matteucci, R. Follis, and M.A. Desiderio Hepatocyte growth factor-activated NF-kappaB regulates HIF-1 activity and ODC expression: implicated in survival, differently in different carcinoma cell lines Carcinogenesis 25 11 2004 2089 2100
-
(2004)
Carcinogenesis
, vol.25
, Issue.11
, pp. 2089-2100
-
-
Tacchini, L.1
De Ponti, C.2
Matteucci, E.3
Follis, R.4
Desiderio, M.A.5
-
158
-
-
84897868101
-
Expression pattern of carbonic anhydrase IX in medullary thyroid carcinoma supports a role for RET-mediated activation of the HIF pathway
-
M. Takacova, P. Bullova, V. Simko, L. Skvarkova, M. Poturnajova, and L. Feketeova Expression pattern of carbonic anhydrase IX in medullary thyroid carcinoma supports a role for RET-mediated activation of the HIF pathway Am J Pathol 184 4 2014 953 965
-
(2014)
Am J Pathol
, vol.184
, Issue.4
, pp. 953-965
-
-
Takacova, M.1
Bullova, P.2
Simko, V.3
Skvarkova, L.4
Poturnajova, M.5
Feketeova, L.6
-
159
-
-
0029840035
-
Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells
-
H. Takagi, G.L. King, G.S. Robinson, N. Ferrara, and L.P. Aiello Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells Investig Ophthalmol Vis Sci 37 11 1996 2165 2176
-
(1996)
Investig Ophthalmol Vis Sci
, vol.37
, Issue.11
, pp. 2165-2176
-
-
Takagi, H.1
King, G.L.2
Robinson, G.S.3
Ferrara, N.4
Aiello, L.P.5
-
160
-
-
83255162011
-
Receptor tyrosine kinases and targeted cancer therapeutics
-
K. Takeuchi, and F. Ito Receptor tyrosine kinases and targeted cancer therapeutics Biol Pharm Bull 34 12 2011 1774 1780
-
(2011)
Biol Pharm Bull
, vol.34
, Issue.12
, pp. 1774-1780
-
-
Takeuchi, K.1
Ito, F.2
-
161
-
-
7944224442
-
Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
-
N. Tang, L. Wang, J. Esko, F.J. Giordano, Y. Huang, and H.P. Gerber Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis Cancer Cell 6 5 2004 485 495
-
(2004)
Cancer Cell
, vol.6
, Issue.5
, pp. 485-495
-
-
Tang, N.1
Wang, L.2
Esko, J.3
Giordano, F.J.4
Huang, Y.5
Gerber, H.P.6
-
162
-
-
0031565271
-
YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits platelet-rich thrombosis in mice
-
C.M. Teng, C.C. Wu, F.N. Ko, F.Y. Lee, and S.C. Kuo YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits platelet-rich thrombosis in mice Eur J Pharmacol 320 2-3 1997 161 166
-
(1997)
Eur J Pharmacol
, vol.320
, Issue.23
, pp. 161-166
-
-
Teng, C.M.1
Wu, C.C.2
Ko, F.N.3
Lee, F.Y.4
Kuo, S.C.5
-
163
-
-
0036128262
-
Hypoxia up-regulates mouse vascular endothelial growth factor D promoter activity in rat pulmonary microvascular smooth-muscle cells
-
X. Teng, D. Li, and R.A. Johns Hypoxia up-regulates mouse vascular endothelial growth factor D promoter activity in rat pulmonary microvascular smooth-muscle cells Chest 121 3 Suppl. 2002 82S 83S
-
(2002)
Chest
, vol.121
, Issue.3
, pp. 82S-83S
-
-
Teng, X.1
Li, D.2
Johns, R.A.3
-
164
-
-
67649774148
-
Recepteur d'origine nantais tyrosine kinase is a direct target of hypoxia-inducible factor-1alpha-mediated invasion of breast carcinoma cells
-
A. Thangasamy, J. Rogge, and S. Ammanamanchi Recepteur d'origine nantais tyrosine kinase is a direct target of hypoxia-inducible factor-1alpha-mediated invasion of breast carcinoma cells J Biol Chem 284 21 2009 14001 14010
-
(2009)
J Biol Chem
, vol.284
, Issue.21
, pp. 14001-14010
-
-
Thangasamy, A.1
Rogge, J.2
Ammanamanchi, S.3
-
165
-
-
0037008770
-
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
-
C. Treins, S. Giorgetti-Peraldi, J. Murdaca, G.L. Semenza, and E. Van Obberghen Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway J Biol Chem 277 31 2002 27975 27981
-
(2002)
J Biol Chem
, vol.277
, Issue.31
, pp. 27975-27981
-
-
Treins, C.1
Giorgetti-Peraldi, S.2
Murdaca, J.3
Semenza, G.L.4
Van Obberghen, E.5
-
166
-
-
44649107292
-
Mechanisms of disease: Cancer stem cells - Targeting the evil twin
-
A. Trumpp, and O.D. Wiestler Mechanisms of disease: cancer stem cells - targeting the evil twin Nat Clin Pract Oncol 5 6 2008 337 347
-
(2008)
Nat Clin Pract Oncol
, vol.5
, Issue.6
, pp. 337-347
-
-
Trumpp, A.1
Wiestler, O.D.2
-
167
-
-
0032549036
-
The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: From orphanhood to multiple stromal ligands
-
E. Tzahar, and Y. Yarden The ErbB-2/HER2 oncogenic receptor of adenocarcinomas: from orphanhood to multiple stromal ligands Biochim Biophys Acta 1377 1 1998 M25 M37
-
(1998)
Biochim Biophys Acta
, vol.1377
, Issue.1
, pp. M25-M37
-
-
Tzahar, E.1
Yarden, Y.2
-
168
-
-
0025343230
-
Signal transduction by receptors with tyrosine kinase activity
-
A. Ullrich, and J. Schlessinger Signal transduction by receptors with tyrosine kinase activity Cell 61 2 1990 203 212
-
(1990)
Cell
, vol.61
, Issue.2
, pp. 203-212
-
-
Ullrich, A.1
Schlessinger, J.2
-
169
-
-
84924871326
-
The potential role of HIF on tumour progression and dissemination
-
S. Unwith The potential role of HIF on tumour progression and dissemination Int J Cancer 2014 10.1002/ijc.28889
-
(2014)
Int J Cancer
-
-
Unwith, S.1
-
170
-
-
20444495979
-
Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation
-
P. Valverde Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation Biochem Biophys Res Commun 333 1 2005 180 185
-
(2005)
Biochem Biophys Res Commun
, vol.333
, Issue.1
, pp. 180-185
-
-
Valverde, P.1
-
171
-
-
3142587028
-
Tumor microenvironmental physiology and its implications for radiation oncology
-
P. Vaupel Tumor microenvironmental physiology and its implications for radiation oncology Semin Radiat Oncol 14 3 2004 198 206
-
(2004)
Semin Radiat Oncol
, vol.14
, Issue.3
, pp. 198-206
-
-
Vaupel, P.1
-
172
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
I. Vivanco, and C.L. Sawyers The phosphatidylinositol 3-kinase AKT pathway in human cancer Nat Rev Cancer 2 7 2002 489 501
-
(2002)
Nat Rev Cancer
, vol.2
, Issue.7
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
173
-
-
77954370385
-
HIF-2alpha-mediated activation of the epidermal growth factor receptor potentiates head and neck cancer cell migration in response to hypoxia
-
X. Wang, and A. Schneider HIF-2alpha-mediated activation of the epidermal growth factor receptor potentiates head and neck cancer cell migration in response to hypoxia Carcinogenesis 31 7 2010 1202 1210
-
(2010)
Carcinogenesis
, vol.31
, Issue.7
, pp. 1202-1210
-
-
Wang, X.1
Schneider, A.2
-
174
-
-
0033119572
-
Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase
-
D. Wang, H.J. Huang, A. Kazlauskas, and W.K. Cavenee Induction of vascular endothelial growth factor expression in endothelial cells by platelet-derived growth factor through the activation of phosphatidylinositol 3-kinase Cancer Res 59 7 1999 1464 1472
-
(1999)
Cancer Res
, vol.59
, Issue.7
, pp. 1464-1472
-
-
Wang, D.1
Huang, H.J.2
Kazlauskas, A.3
Cavenee, W.K.4
-
175
-
-
7244236494
-
Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo
-
E.S. Wang, J. Teruya-Feldstein, Y. Wu, Z. Zhu, D.J. Hicklin, and M.A. Moore Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo Blood 104 9 2004 2893 2902
-
(2004)
Blood
, vol.104
, Issue.9
, pp. 2893-2902
-
-
Wang, E.S.1
Teruya-Feldstein, J.2
Wu, Y.3
Zhu, Z.4
Hicklin, D.J.5
Moore, M.A.6
-
176
-
-
61949090107
-
Regulation of endocytosis via the oxygen-sensing pathway
-
Y. Wang, O. Roche, M.S. Yan, G. Finak, A.J. Evans, and J.L. Metcalf Regulation of endocytosis via the oxygen-sensing pathway Nat Med 15 3 2009 319 324
-
(2009)
Nat Med
, vol.15
, Issue.3
, pp. 319-324
-
-
Wang, Y.1
Roche, O.2
Yan, M.S.3
Finak, G.4
Evans, A.J.5
Metcalf, J.L.6
-
177
-
-
84859454686
-
Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1
-
Y. Wang, O. Roche, C. Xu, E.H. Moriyama, P. Heir, and J. Chung Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1 Proc Natl Acad Sci USA 109 13 2012 4892 4897
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, Issue.13
, pp. 4892-4897
-
-
Wang, Y.1
Roche, O.2
Xu, C.3
Moriyama, E.H.4
Heir, P.5
Chung, J.6
-
178
-
-
49849099471
-
Intrinsically lower AKT: Mammalian target of rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-d-glucose under hypoxia in lung cancer cell lines
-
M. Wangpaichitr, N. Savaraj, J. Maher, M. Kurtoglu, and T.J. Lampidis Intrinsically lower AKT: mammalian target of rapamycin, and hypoxia-inducible factor activity correlates with increased sensitivity to 2-deoxy-d-glucose under hypoxia in lung cancer cell lines Mol Cancer Ther 7 6 2008 1506 1513
-
(2008)
Mol Cancer Ther
, vol.7
, Issue.6
, pp. 1506-1513
-
-
Wangpaichitr, M.1
Savaraj, N.2
Maher, J.3
Kurtoglu, M.4
Lampidis, T.J.5
-
179
-
-
74549159014
-
The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells
-
J.W. Welsh, D. Mahadevan, R. Ellsworth, L. Cooke, D. Bearss, and B. Stea The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells Radiat Oncol 4 2009 69
-
(2009)
Radiat Oncol
, vol.4
, pp. 69
-
-
Welsh, J.W.1
Mahadevan, D.2
Ellsworth, R.3
Cooke, L.4
Bearss, D.5
Stea, B.6
-
180
-
-
0034649507
-
Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling
-
C.C. Wykoff, C.W. Pugh, P.H. Maxwell, A.L. Harris, and P.J. Ratcliffe Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling Oncogene 19 54 2000 6297 6305
-
(2000)
Oncogene
, vol.19
, Issue.54
, pp. 6297-6305
-
-
Wykoff, C.C.1
Pugh, C.W.2
Maxwell, P.H.3
Harris, A.L.4
Ratcliffe, P.J.5
-
181
-
-
0034671307
-
Hypoxia-inducible expression of tumor-associated carbonic anhydrases
-
C.C. Wykoff, N.J. Beasley, P.H. Watson, K.J. Turner, J. Pastorek, and A. Sibtain Hypoxia-inducible expression of tumor-associated carbonic anhydrases Cancer Res 60 24 2000 7075 7083
-
(2000)
Cancer Res
, vol.60
, Issue.24
, pp. 7075-7083
-
-
Wykoff, C.C.1
Beasley, N.J.2
Watson, P.H.3
Turner, K.J.4
Pastorek, J.5
Sibtain, A.6
-
182
-
-
24644457736
-
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways
-
Q. Xu, J. Briggs, S. Park, G. Niu, M. Kortylewski, and S. Zhang Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways Oncogene 24 36 2005 5552 5560
-
(2005)
Oncogene
, vol.24
, Issue.36
, pp. 5552-5560
-
-
Xu, Q.1
Briggs, J.2
Park, S.3
Niu, G.4
Kortylewski, M.5
Zhang, S.6
-
183
-
-
77952238683
-
Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1alpha in non-small cell lung cancer cells
-
L. Xu, M.B. Nilsson, P. Saintigny, T. Cascone, M.H. Herynk, and Z. Du Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1alpha in non-small cell lung cancer cells Oncogene 29 18 2010 2616 2627
-
(2010)
Oncogene
, vol.29
, Issue.18
, pp. 2616-2627
-
-
Xu, L.1
Nilsson, M.B.2
Saintigny, P.3
Cascone, T.4
Herynk, M.H.5
Du, Z.6
-
184
-
-
0036006727
-
Differential regulation of glial cell line-derived neurotrophic factor (GDNF) mRNA expression during hypoxia and reoxygenation in astrocytes isolated from stroke-prone spontaneously hypertensive rats
-
K. Yamagata, M. Tagami, K. Ikeda, S. Tsumagari, Y. Yamori, and Y. Nara Differential regulation of glial cell line-derived neurotrophic factor (GDNF) mRNA expression during hypoxia and reoxygenation in astrocytes isolated from stroke-prone spontaneously hypertensive rats Glia 37 1 2002 1 7
-
(2002)
Glia
, vol.37
, Issue.1
, pp. 1-7
-
-
Yamagata, K.1
Tagami, M.2
Ikeda, K.3
Tsumagari, S.4
Yamori, Y.5
Nara, Y.6
-
185
-
-
0035256698
-
Untangling the ErbB signalling network
-
Y. Yarden, and M.X. Sliwkowski Untangling the ErbB signalling network Nat Rev Mol Cell Biol 2 2 2001 127 137
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, Issue.2
, pp. 127-137
-
-
Yarden, Y.1
Sliwkowski, M.X.2
-
186
-
-
0034691674
-
Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis
-
L. Yen, X.L. You, A.E. Al Moustafa, G. Batist, N.E. Hynes, and S. Mader Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis Oncogene 19 31 2000 3460 3469
-
(2000)
Oncogene
, vol.19
, Issue.31
, pp. 3460-3469
-
-
Yen, L.1
You, X.L.2
Al Moustafa, A.E.3
Batist, G.4
Hynes, N.E.5
Mader, S.6
-
187
-
-
0037414180
-
YC-1: A potential anticancer drug targeting hypoxia-inducible factor 1
-
E.J. Yeo, Y.S. Chun, Y.S. Cho, J. Kim, J.C. Lee, and M.S. Kim YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1 J Natl Cancer Inst 95 7 2003 516 525
-
(2003)
J Natl Cancer Inst
, vol.95
, Issue.7
, pp. 516-525
-
-
Yeo, E.J.1
Chun, Y.S.2
Cho, Y.S.3
Kim, J.4
Lee, J.C.5
Kim, M.S.6
-
188
-
-
84869237379
-
Mechanisms of acquired resistance to tyrosine kinase inhibitors
-
C. Yi-fan, and F. Li-wu Mechanisms of acquired resistance to tyrosine kinase inhibitors Acta Pharm Sin B 1 4 2011 197 207
-
(2011)
Acta Pharm Sin B
, vol.1
, Issue.4
, pp. 197-207
-
-
Yi-Fan, C.1
Li-Wu, F.2
-
189
-
-
30944442620
-
Hypoxia inducible factor 1-alpha regulates of platelet derived growth factor-B in human glioblastoma cells
-
D. Yoshida, K. Kim, M. Noha, and A. Teramoto Hypoxia inducible factor 1-alpha regulates of platelet derived growth factor-B in human glioblastoma cells J Neurooncol 76 1 2006 13 21
-
(2006)
J Neurooncol
, vol.76
, Issue.1
, pp. 13-21
-
-
Yoshida, D.1
Kim, K.2
Noha, M.3
Teramoto, A.4
-
190
-
-
0032169214
-
Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT
-
E. Zelzer, Y. Levy, C. Kahana, B.Z. Shilo, M. Rubinstein, and B. Cohen Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT EMBO J 17 17 1998 5085 5094
-
(1998)
EMBO J
, vol.17
, Issue.17
, pp. 5085-5094
-
-
Zelzer, E.1
Levy, Y.2
Kahana, C.3
Shilo, B.Z.4
Rubinstein, M.5
Cohen, B.6
-
191
-
-
0030962307
-
Gene expression profiles in normal and cancer cells
-
L. Zhang, W. Zhou, V.E. Velculescu, S.E. Kern, R.H. Hruban, and S.R. Hamilton Gene expression profiles in normal and cancer cells Science 276 5316 1997 1268 1272
-
(1997)
Science
, vol.276
, Issue.5316
, pp. 1268-1272
-
-
Zhang, L.1
Zhou, W.2
Velculescu, V.E.3
Kern, S.E.4
Hruban, R.H.5
Hamilton, S.R.6
-
192
-
-
58149374576
-
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth
-
H. Zhang, D.Z. Qian, Y.S. Tan, K. Lee, P. Gao, and Y.R. Ren Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth Proc Natl Acad Sci USA 105 50 2008 19579 19586
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.50
, pp. 19579-19586
-
-
Zhang, H.1
Qian, D.Z.2
Tan, Y.S.3
Lee, K.4
Gao, P.5
Ren, Y.R.6
-
193
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
H. Zhong, K. Chiles, D. Feldser, E. Laughner, C. Hanrahan, and M.M. Georgescu Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics Cancer Res 60 6 2000 1541 1545
-
(2000)
Cancer Res
, vol.60
, Issue.6
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
Laughner, E.4
Hanrahan, C.5
Georgescu, M.M.6
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