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Volumn 65, Issue 8, 2005, Pages 3257-3263

A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIGASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN SUBUNIT;

EID: 17144372970     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-1284     Document Type: Article
Times cited : (98)

References (31)
  • 1
    • 0242468905 scopus 로고    scopus 로고
    • Dysregulation of cellular signaling by HER2/neu in breast cancer
    • Zhou BP, Hung MC. Dysregulation of cellular signaling by HER2/neu in breast cancer. Semin Oncol 2003;30:38-48.
    • (2003) Semin Oncol , vol.30 , pp. 38-48
    • Zhou, B.P.1    Hung, M.C.2
  • 3
    • 0024337144 scopus 로고
    • Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
    • Slamon DJ, Godolphin W, Jones LA, et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 1989;244:707-12.
    • (1989) Science , vol.244 , pp. 707-712
    • Slamon, D.J.1    Godolphin, W.2    Jones, L.A.3
  • 4
    • 0034677776 scopus 로고    scopus 로고
    • HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/ NF-κB pathway
    • Zhou BP, Hu MC, Miller SA, et al. HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/ NF-κB pathway. J Biol Chem 2000;275:8027-31.
    • (2000) J Biol Chem , vol.275 , pp. 8027-8031
    • Zhou, B.P.1    Hu, M.C.2    Miller, S.A.3
  • 5
    • 0034745353 scopus 로고    scopus 로고
    • Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
    • Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 2001;3:245-52.
    • (2001) Nat Cell Biol , vol.3 , pp. 245-252
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Spohn, B.4    Lee, M.H.5    Hung, M.C.6
  • 6
    • 0035736487 scopus 로고    scopus 로고
    • HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
    • Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC. HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation. Nat Cell Biol 2001;3:973-82.
    • (2001) Nat Cell Biol , vol.3 , pp. 973-982
    • Zhou, B.P.1    Liao, Y.2    Xia, W.3    Zou, Y.4    Spohn, B.5    Hung, M.C.6
  • 7
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000;407:249-57.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 8
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: Role of the HIF system
    • Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 2003;9:677-84.
    • (2003) Nat Med , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 9
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-32.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 10
    • 0037872699 scopus 로고    scopus 로고
    • Angiogenesis in ischemic and neoplastic disorders
    • Semenza GL. Angiogenesis in ischemic and neoplastic disorders. Annu Rev Med 2003;54:17-28.
    • (2003) Annu Rev Med , vol.54 , pp. 17-28
    • Semenza, G.L.1
  • 11
    • 0036710591 scopus 로고    scopus 로고
    • Signal transduction to hypoxiainducible factor 1
    • Semenza G. Signal transduction to hypoxiainducible factor 1. Biochem Pharmacol 2002;64:993-8.
    • (2002) Biochem Pharmacol , vol.64 , pp. 993-998
    • Semenza, G.1
  • 12
    • 0030914648 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factor 1α: Posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor
    • Kallio PJ, Pongratz I, Gradin K, McGuire J, Poellinger L. Activation of hypoxia-inducible factor 1α: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor. Proc Natl Acad Sci U S A 1997;94:5667-72.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 5667-5672
    • Kallio, P.J.1    Pongratz, I.2    Gradin, K.3    McGuire, J.4    Poellinger, L.5
  • 13
    • 0029888061 scopus 로고    scopus 로고
    • The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells
    • Wood SM, Gleadle JM, Pugh CW, Hankinson O, Ratcliffe PJ. The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells. J Biol Chem 1996;271:15117-23.
    • (1996) J Biol Chem , vol.271 , pp. 15117-15123
    • Wood, S.M.1    Gleadle, J.M.2    Pugh, C.W.3    Hankinson, O.4    Ratcliffe, P.J.5
  • 14
    • 0030943461 scopus 로고    scopus 로고
    • Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
    • Maltepe E, Schmidt JV, Baunoch D, Bradfield CA, Simon MC. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 1997;386:403-7.
    • (1997) Nature , vol.386 , pp. 403-407
    • Maltepe, E.1    Schmidt, J.V.2    Baunoch, D.3    Bradfield, C.A.4    Simon, M.C.5
  • 15
    • 0030588298 scopus 로고    scopus 로고
    • Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia
    • Salceda S, Beck I, Caro J. Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia. Arch Biochem Biophys 1996;334:389-94.
    • (1996) Arch Biochem Biophys , vol.334 , pp. 389-394
    • Salceda, S.1    Beck, I.2    Caro, J.3
  • 17
    • 0034050050 scopus 로고    scopus 로고
    • Loss of PTEN facilitates HIF-1-mediated gene expression
    • Zundel W, Schindler C, Haas-Kogan D, et al. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 2000;14:391-6.
    • (2000) Genes Dev , vol.14 , pp. 391-396
    • Zundel, W.1    Schindler, C.2    Haas-Kogan, D.3
  • 18
    • 0037134442 scopus 로고    scopus 로고
    • Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension
    • Alvarez-Tejado M, Alfranca A, Aragones J, Vara A, Landazuri MO, del Peso L. Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension. J Biol Chem 2002;277:13508-17.
    • (2002) J Biol Chem , vol.277 , pp. 13508-13517
    • Alvarez-Tejado, M.1    Alfranca, A.2    Aragones, J.3    Vara, A.4    Landazuri, M.O.5    Del Peso, L.6
  • 19
    • 0037177867 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 α nor sufficient for HIF-1-dependent target gene transcription
    • Arsham AM, Plas DR, Thompson CB, Simon MC. Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 α nor sufficient for HIF-1-dependent target gene transcription. J Biol Chem 2002;277:15162-70.
    • (2002) J Biol Chem , vol.277 , pp. 15162-15170
    • Arsham, A.M.1    Plas, D.R.2    Thompson, C.B.3    Simon, M.C.4
  • 21
    • 0035872479 scopus 로고    scopus 로고
    • Dynamic, site-specific interaction of hypoxia-inducible factor-1α with the von Hippel-Lindau tumor suppressor protein
    • Yu F, White SB, Zhao Q, Lee FS. Dynamic, site-specific interaction of hypoxia-inducible factor-1α with the von Hippel-Lindau tumor suppressor protein. Cancer Res 2001;61:4136-42.
    • (2001) Cancer Res , vol.61 , pp. 4136-4142
    • Yu, F.1    White, S.B.2    Zhao, Q.3    Lee, F.S.4
  • 22
    • 0030667728 scopus 로고    scopus 로고
    • CBP/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt)
    • Tokyo
    • Kobayashi A, Numayama-Tsuruta K, Sogawa K, Fujii-Kuriyama Y. CBP/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt). J Biochem (Tokyo) 1997;122:703-10.
    • (1997) J Biochem , vol.122 , pp. 703-710
    • Kobayashi, A.1    Numayama-Tsuruta, K.2    Sogawa, K.3    Fujii-Kuriyama, Y.4
  • 23
    • 0033673463 scopus 로고    scopus 로고
    • A tetratricopeptide repeat half-site in the aryl hydrocarbon receptor is important for DNA binding and transactivation potential
    • Levine SL, Petrulis JR, Dubil A, Perdew GH. A tetratricopeptide repeat half-site in the aryl hydrocarbon receptor is important for DNA binding and transactivation potential. Mol Pharmacol 2000;58:1517-24.
    • (2000) Mol Pharmacol , vol.58 , pp. 1517-1524
    • Levine, S.L.1    Petrulis, J.R.2    Dubil, A.3    Perdew, G.H.4
  • 24
    • 7944223780 scopus 로고    scopus 로고
    • Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis
    • Li YM, Pan Y, Wei Y, et al. Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell 2004;6:459-69.
    • (2004) Cancer Cell , vol.6 , pp. 459-469
    • Li, Y.M.1    Pan, Y.2    Wei, Y.3
  • 25
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002;296:1655-7.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 26
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 2001;21:3995-4004.
    • (2001) Mol Cell Biol , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 27
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/ PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D, et al. Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/ PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000;60:1541-5.
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3
  • 28
    • 0043234256 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor-1α protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/ Akt/glycogen synthase kinase 3β pathway in HepG2 cells
    • Mottet D, Dumont V, Deccache Y, et al. Regulation of hypoxia-inducible factor-1α protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/ Akt/glycogen synthase kinase 3β pathway in HepG2 cells. J Biol Chem 2003;278:31277-85.
    • (2003) J Biol Chem , vol.278 , pp. 31277-31285
    • Mottet, D.1    Dumont, V.2    Deccache, Y.3
  • 29
    • 0037008770 scopus 로고    scopus 로고
    • Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
    • Treins C, Giorgetti-Peraldi S, Murdaca J, Semenza GL Van Obberghen E. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J Biol Chem 2002;277:27975-81.
    • (2002) J Biol Chem , vol.277 , pp. 27975-27981
    • Treins, C.1    Giorgetti-Peraldi, S.2    Murdaca, J.3    Semenza, G.L.4    Van Obberghen, E.5
  • 30
    • 0037149539 scopus 로고    scopus 로고
    • Tumour biology: Herceptin acts as an anti-angiogenic cocktail
    • Izumi Y, Xu L, di Tomaso E, Fukumura D, Jain RK. Tumour biology: herceptin acts as an anti-angiogenic cocktail. Nature 2002;416:279-80.
    • (2002) Nature , vol.416 , pp. 279-280
    • Izumi, Y.1    Xu, L.2    Di Tomaso, E.3    Fukumura, D.4    Jain, R.K.5
  • 31
    • 0141787069 scopus 로고    scopus 로고
    • Combined trastuzumab and paclitaxel treatment better inhibits ErbB-2-mediated angiogenesis in breast carcinoma through a more effective inhibition of Akt than either treatment alone
    • Klos KS, Zhou X, Lee S, et al. Combined trastuzumab and paclitaxel treatment better inhibits ErbB-2-mediated angiogenesis in breast carcinoma through a more effective inhibition of Akt than either treatment alone. Cancer 2003;98:1377-85.
    • (2003) Cancer , vol.98 , pp. 1377-1385
    • Klos, K.S.1    Zhou, X.2    Lee, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.