메뉴 건너뛰기




Volumn 14, Issue 20, 2008, Pages 6364-6370

The type 1 insulin-like growth factor receptor pathway

Author keywords

[No Author keywords available]

Indexed keywords

A 928605; AMG 479; ANTINEOPLASTIC AGENT; AVE 1642; BIIB 022; BMS 536924; BMS 554417; CP 751871; EPIDERMAL GROWTH FACTOR RECEPTOR; GEMCITABINE; IMC A12; INSM 18; MK 0646; OSI 906; PANITUMUMAB; PROTEIN P53; R 1507; SCH 717454; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; XL 228; INSULIN RECEPTOR;

EID: 56749110996     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-07-4879     Document Type: Review
Times cited : (373)

References (75)
  • 1
    • 0022800838 scopus 로고
    • Insulin-like growth factor I receptor primary structure: Comparison with insulin receptor suggests structural determinants that define functional specificity
    • Ullrich A, Gray A, Tam AW, et al. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J 1986;5:2503-12.
    • (1986) EMBO J , vol.5 , pp. 2503-2512
    • Ullrich, A.1    Gray, A.2    Tam, A.W.3
  • 2
    • 0033906634 scopus 로고    scopus 로고
    • Structure and function of the type1insulin-like growth factorre-ceptor
    • Adams TE, Epa VC, Garrett TP, Ward CW. Structure and function of the type1insulin-like growth factorre-ceptor. Cell Mol Life Sci 2000;57:1050-93.
    • (2000) Cell Mol Life Sci , vol.57 , pp. 1050-1093
    • Adams, T.E.1    Epa, V.C.2    Garrett, T.P.3    Ward, C.W.4
  • 3
    • 34047174592 scopus 로고    scopus 로고
    • The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer
    • Belfiore A. The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer. Curr Pharm Des 2007;13:671-86.
    • (2007) Curr Pharm Des , vol.13 , pp. 671-686
    • Belfiore, A.1
  • 4
    • 33750374137 scopus 로고    scopus 로고
    • The twentieth century struggle to decipher insulin signaling
    • Cohen P. The twentieth century struggle to decipher insulin signaling. Nat Rev Mol Cell Biol 2006;7:867-73.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 867-873
    • Cohen, P.1
  • 5
    • 0242594016 scopus 로고    scopus 로고
    • The IGF-1 receptor in cancer biology
    • Baserga R, Peruzzi F, Reiss K. The IGF-1 receptor in cancer biology. Int J Cancer 2003;107:873 -7.
    • (2003) Int J Cancer , vol.107 , pp. 873-877
    • Baserga, R.1    Peruzzi, F.2    Reiss, K.3
  • 6
    • 34250788809 scopus 로고    scopus 로고
    • Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007;129:1261 -74.
    • Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007;129:1261 -74.
  • 7
    • 0037032817 scopus 로고    scopus 로고
    • Mitogen-activated protein kinasepathwaysmediated byERK, JNK, and p38protein kinases
    • Johnson GL, Lapadat R. Mitogen-activated protein kinasepathwaysmediated byERK, JNK, and p38protein kinases. Science 2002;298:1911 -2.
    • (2002) Science , vol.298 , pp. 1911-1912
    • Johnson, G.L.1    Lapadat, R.2
  • 8
    • 0036905115 scopus 로고    scopus 로고
    • Cellular actions of the insulinlike growth factor binding proteins
    • Firth SM, Baxter RC. Cellular actions of the insulinlike growth factor binding proteins. Endocr Rev 2002;23:824-54.
    • (2002) Endocr Rev , vol.23 , pp. 824-854
    • Firth, S.M.1    Baxter, R.C.2
  • 10
    • 0346725862 scopus 로고    scopus 로고
    • Regulation of IGF-I receptor signaling in tumor cells
    • O'Connor R. Regulation of IGF-I receptor signaling in tumor cells. Horm Metab Res 2003;35:771-7.
    • (2003) Horm Metab Res , vol.35 , pp. 771-777
    • O'Connor, R.1
  • 11
    • 33947538050 scopus 로고    scopus 로고
    • Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
    • Wan X, Harkavy B, Shen N, Grohar P, Helman LJ. Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 2007;26:1932 -40.
    • (2007) Oncogene , vol.26 , pp. 1932-1940
    • Wan, X.1    Harkavy, B.2    Shen, N.3    Grohar, P.4    Helman, L.J.5
  • 12
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type1 IGF receptor (Igf1r)
    • Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type1 IGF receptor (Igf1r). Cell 1993;75:59-72.
    • (1993) Cell , vol.75 , pp. 59-72
    • Liu, J.P.1    Baker, J.2    Perkins, A.S.3    Robertson, E.J.4    Efstratiadis, A.5
  • 13
    • 33847216159 scopus 로고    scopus 로고
    • Essential role of insulin and insulin-like growth factor1 receptor signaling in cardiac development and function
    • Laustsen PG, Russell SJ, Cui L, et al. Essential role of insulin and insulin-like growth factor1 receptor signaling in cardiac development and function. Mol Cell Biol 2007;27:1649 -64.
    • (2007) Mol Cell Biol , vol.27 , pp. 1649-1664
    • Laustsen, P.G.1    Russell, S.J.2    Cui, L.3
  • 14
    • 28844432459 scopus 로고    scopus 로고
    • The insulin-like growth factor system and its pleiotropic functions in brain
    • RussoVC, Gluckman PD, Feldman EL,Werther GA. The insulin-like growth factor system and its pleiotropic functions in brain. Endocr Rev 2005;26:916 -43.
    • (2005) Endocr Rev , vol.26 , pp. 916-943
    • Russo, V.C.1    Gluckman, P.D.2    Feldman, E.L.3    Werther, G.A.4
  • 15
    • 35648973774 scopus 로고    scopus 로고
    • DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans
    • Pinkston-GosseJ, Kenyon C. DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans.Nat Genet2007;39:1403-9.
    • Nat Genet2007;39 , pp. 1403-1409
    • GosseJ, P.1    Kenyon, C.2
  • 16
    • 0030962307 scopus 로고    scopus 로고
    • Gene expression profiles in normal and cancer cells
    • Zhang L, Zhou W,Velculescu VE, et al. Gene expression profiles in normal and cancer cells. Science1997;276:1268-72.
    • Science1997;276 , pp. 1268-1272
    • Zhang, L.1    Zhou, W.2    Velculescu, V.E.3
  • 17
    • 33847358273 scopus 로고    scopus 로고
    • Cui H.Loss of imprinting of IGF2asanepigenetic marker for the risk of human cancer. Dis Markers 2007;23:105-12.
    • Cui H.Loss of imprinting of IGF2asanepigenetic marker for the risk of human cancer. Dis Markers 2007;23:105-12.
  • 18
    • 33745209256 scopus 로고    scopus 로고
    • Mannose- 6-phosphate/insulin-like growth factor II receptor expression and tumor development
    • Hebert E. Mannose- 6-phosphate/insulin-like growth factor II receptor expression and tumor development. Biosci Rep 2006;26:7 -17.
    • (2006) Biosci Rep , vol.26 , pp. 7-17
    • Hebert, E.1
  • 19
    • 33745211914 scopus 로고    scopus 로고
    • Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer
    • Sarfstein R, Maor S, Reizner N, Abramovitch S, Werner H. Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer. Mol Cell Endocrinol 2006;252:241-6.
    • (2006) Mol Cell Endocrinol , vol.252 , pp. 241-246
    • Sarfstein, R.1    Maor, S.2    Reizner, N.3    Abramovitch, S.4    Werner, H.5
  • 20
    • 34948858983 scopus 로고    scopus 로고
    • The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma
    • Yuen JS,Cockman ME, SullivanM,et al. The VHL tumor suppressor inhibits expression of the IGF1R and its loss induces IGF1R upregulation in human clear cell renal carcinoma. Oncogene 2007;26:6499-508.
    • (2007) Oncogene , vol.26 , pp. 6499-6508
    • Yuen, J.S.1    Cockman, M.E.2    Sullivan, M.3
  • 21
    • 33745727112 scopus 로고    scopus 로고
    • HER2 kinase domain mutation results in constitutive phos-phorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors
    • Wang SE, Narasanna A, Perez-Torres M, et al. HER2 kinase domain mutation results in constitutive phos-phorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell 2006;10:25-38.
    • (2006) Cancer Cell , vol.10 , pp. 25-38
    • Wang, S.E.1    Narasanna, A.2    Perez-Torres, M.3
  • 22
    • 0036692208 scopus 로고    scopus 로고
    • High expression levels of insulin-like growth factor-I receptor predictpoor survival among women with clear-cell renal cell carcinomas
    • ParkerAS, ChevilleJC, JanneyCA, Cerhan JR. High expression levels of insulin-like growth factor-I receptor predictpoor survival among women with clear-cell renal cell carcinomas. Hum Pathol 2002;33:801-5.
    • (2002) Hum Pathol , vol.33 , pp. 801-805
    • Parker, A.S.1    Cheville, J.C.2    Janney, C.A.3    Cerhan, J.R.4
  • 23
    • 35948983048 scopus 로고    scopus 로고
    • IGF axis gene expression patterns are prognostic of survival in epithelial ovarian cancer
    • Spentzos D, Cannistra SA, Grall F, et al. IGF axis gene expression patterns are prognostic of survival in epithelial ovarian cancer. Endocr Relat Cancer 2007;14:781-90.
    • (2007) Endocr Relat Cancer , vol.14 , pp. 781-790
    • Spentzos, D.1    Cannistra, S.A.2    Grall, F.3
  • 24
    • 0028332092 scopus 로고
    • Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryofibroblasts
    • Sell C, Dumenil G, Deveaud C, et al. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryofibroblasts. Mol Cell Biol 1994;14:3604-12.
    • (1994) Mol Cell Biol , vol.14 , pp. 3604-3612
    • Sell, C.1    Dumenil, G.2    Deveaud, C.3
  • 25
    • 0036559535 scopus 로고    scopus 로고
    • Elevated levels ofIGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis
    • LopezT, Hanahan D. Elevated levels ofIGF-1 receptor convey invasive and metastatic capability in a mouse model of pancreatic islet tumorigenesis. Cancer Cell 2002;1:339-53.
    • (2002) Cancer Cell , vol.1 , pp. 339-353
    • Lopez, T.1    Hanahan, D.2
  • 26
    • 33947121226 scopus 로고    scopus 로고
    • Transgen-ic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation
    • Jones RA, Campbell CI, Gunther EJ, et al. Transgen-ic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation. Oncogene 2007;26:1636 -44.
    • (2007) Oncogene , vol.26 , pp. 1636-1644
    • Jones, R.A.1    Campbell, C.I.2    Gunther, E.J.3
  • 27
    • 43349088787 scopus 로고    scopus 로고
    • Targeting the type1 Insulinlike growth factor receptor as a treatment for cancer
    • Yuen JS, MacaulayVM. Targeting the type1 Insulinlike growth factor receptor as a treatment for cancer. Expert OpinTherTargets 2008;12:589 603.
    • (2008) Expert OpinTherTargets , vol.12 , pp. 589-603
    • Yuen, J.S.1    MacaulayVM2
  • 28
    • 33846874575 scopus 로고    scopus 로고
    • The role of the IGF system in cancer growth and metastasis: Overview and recent insights
    • Samani AA,Yakar S, LeRoith D, Brodt P. The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev 2007;28:20-47.
    • (2007) Endocr Rev , vol.28 , pp. 20-47
    • Samani, A.A.1    Yakar, S.2    LeRoith, D.3    Brodt, P.4
  • 29
    • 36348970313 scopus 로고    scopus 로고
    • Targeted therapies in Ewing's sarcoma
    • Scotlandi K. Targeted therapies in Ewing's sarcoma. Adv Exp Med Biol 2006;587:13 -22.
    • (2006) Adv Exp Med Biol , vol.587 , pp. 13-22
    • Scotlandi, K.1
  • 30
    • 0028050256 scopus 로고    scopus 로고
    • Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor
    • Resnicoff M, Coppola D,Sell C, Rubin R, Ferrone S, Baserga R. Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor. Cancer Res1994;54:4848-50.
    • Cancer Res1994;54 , pp. 4848-4850
    • Resnicoff, M.1    Coppola, D.2    Sell, C.3    Rubin, R.4    Ferrone, S.5    Baserga, R.6
  • 31
    • 10844296820 scopus 로고    scopus 로고
    • Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer
    • Rochester MA, Riedemann J, Hellawell GO, Brewster SF, Macaulay VM. Silencing of the IGF1R gene enhances sensitivity to DNA-damaging agents in both PTEN wild-type and mutant human prostate cancer. Cancer GeneTher 2005;12:90-100.
    • (2005) Cancer GeneTher , vol.12 , pp. 90-100
    • Rochester, M.A.1    Riedemann, J.2    Hellawell, G.O.3    Brewster, S.F.4    Macaulay, V.M.5
  • 32
    • 0037096744 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer
    • Lee HY, Chun KH, Liu B, et al. Insulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer. Cancer Res 2002;62:3530-7.
    • (2002) Cancer Res , vol.62 , pp. 3530-3537
    • Lee, H.Y.1    Chun, K.H.2    Liu, B.3
  • 33
    • 33644506750 scopus 로고    scopus 로고
    • Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting
    • Harper J, Burns JL, Foulstone EJ, Pignatelli M, Zaina S, Hassan AB. Soluble IGF2 receptor rescues Apc(Min/+) intestinal adenoma progression induced by Igf2 loss of imprinting. Cancer Res 2006;66:1940-8.
    • (2006) Cancer Res , vol.66 , pp. 1940-1948
    • Harper, J.1    Burns, J.L.2    Foulstone, E.J.3    Pignatelli, M.4    Zaina, S.5    Hassan, A.B.6
  • 34
    • 0032146711 scopus 로고    scopus 로고
    • A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer
    • Dunn SE, Ehrlich M, Sharp NJ, et al. A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer. Cancer Res1998;58:3353-61.
    • Cancer Res1998;58 , pp. 3353-3361
    • Dunn, S.E.1    Ehrlich, M.2    Sharp, N.J.3
  • 35
    • 31544464616 scopus 로고    scopus 로고
    • In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417
    • Haluska P, Carboni JM, Loegering DA, et al. In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417. Cancer Res 2006;66:362 -71.
    • (2006) Cancer Res , vol.66 , pp. 362-371
    • Haluska, P.1    Carboni, J.M.2    Loegering, D.A.3
  • 36
    • 38749114995 scopus 로고    scopus 로고
    • Oncogenes and cancer
    • Croce CM. Oncogenes and cancer. N Engl J Med 2008;358:502-11.
    • (2008) N Engl J Med , vol.358 , pp. 502-511
    • Croce, C.M.1
  • 37
    • 34047248571 scopus 로고    scopus 로고
    • Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
    • Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, et al. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res 2007;67:2643-8.
    • (2007) Cancer Res , vol.67 , pp. 2643-2648
    • Benvenuti, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3
  • 38
    • 33748345653 scopus 로고    scopus 로고
    • Human melanoma cells expressing V600E B-RAF are susceptible to IGF1R targeting by small interfering RNAs
    • Yeh AH, Bohula EA, MacaulayVM. Human melanoma cells expressing V600E B-RAF are susceptible to IGF1R targeting by small interfering RNAs. Oncogene 2006;25:6574-81.
    • (2006) Oncogene , vol.25 , pp. 6574-6581
    • Yeh, A.H.1    Bohula, E.A.2    MacaulayVM3
  • 39
    • 35948940097 scopus 로고    scopus 로고
    • An antibody targeting the type I insulin-like growth factor receptor enhances the castration-induced response in andro-gen-dependent prostate cancer
    • Plymate SR, Haugk K, Coleman I, et al. An antibody targeting the type I insulin-like growth factor receptor enhances the castration-induced response in andro-gen-dependent prostate cancer. Clin Cancer Res 2007;13:6429-39.
    • (2007) Clin Cancer Res , vol.13 , pp. 6429-6439
    • Plymate, S.R.1    Haugk, K.2    Coleman, I.3
  • 40
    • 0030738695 scopus 로고    scopus 로고
    • Insulinlike growth factor 1 (IGF-1) alters drug sensitivity of HBL100 human breast cancer cells byinhibition of apoptosis induced by diverse anticancer drugs
    • Dunn SE, Hardman RA, Kari FW, Barrett JC. Insulinlike growth factor 1 (IGF-1) alters drug sensitivity of HBL100 human breast cancer cells byinhibition of apoptosis induced by diverse anticancer drugs. Cancer Res 1997;57:2687-93.
    • (1997) Cancer Res , vol.57 , pp. 2687-2693
    • Dunn, S.E.1    Hardman, R.A.2    Kari, F.W.3    Barrett, J.C.4
  • 41
    • 10744232798 scopus 로고    scopus 로고
    • Trojanek J, HoT, Del Valle L, et al. Role of the insulinlike growth factor I/insulin receptor substrate1 axis in Rad51 trafficking and DNA repair by homologous recombination.Mol Cell Biol 2003;23:7510-24.
    • Trojanek J, HoT, Del Valle L, et al. Role of the insulinlike growth factor I/insulin receptor substrate1 axis in Rad51 trafficking and DNA repair by homologous recombination.Mol Cell Biol 2003;23:7510-24.
  • 42
    • 0036141447 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
    • Chakravarti A, Loeffler JS, Dyson NJ. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res 2002;62:200-7.
    • (2002) Cancer Res , vol.62 , pp. 200-207
    • Chakravarti, A.1    Loeffler, J.S.2    Dyson, N.J.3
  • 43
    • 61349178104 scopus 로고    scopus 로고
    • HER receptorsig-naling confers resistance to IGF-1R targeted therapy
    • abstr14510, May 20
    • Haluska P, Carboni JM,Yu C,et al. HER receptorsig-naling confers resistance to IGF-1R targeted therapy. J. Clin. Oncol. 26: 2008 (May 20 suppl; abstr14510).
    • (2008) J. Clin. Oncol , vol.26 , Issue.SUPPL.
    • Haluska, P.1    Carboni, J.M.2    Yu, C.3
  • 44
    • 21244441508 scopus 로고    scopus 로고
    • A fully human recom-binant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity
    • Lu D, Zhang H, Koo H, et al. A fully human recom-binant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity. J Biol Chem 2005;280:19665-72.
    • (2005) J Biol Chem , vol.280 , pp. 19665-19672
    • Lu, D.1    Zhang, H.2    Koo, H.3
  • 45
    • 33746867442 scopus 로고    scopus 로고
    • Recombinant human insulin-like growth factor binding protein 3 inhibits growth of human epidermal growth factor receptor-2-overexpressing breast tumors and potentiates herceptin activity in vivo
    • Jerome L, AlamiN,BelangerS,et al. Recombinant human insulin-like growth factor binding protein 3 inhibits growth of human epidermal growth factor receptor-2-overexpressing breast tumors and potentiates herceptin activity in vivo. Cancer Res 2006;66:7245 -52.
    • (2006) Cancer Res , vol.66 , pp. 7245-7252
    • Jerome, L.1    Alami, N.2    Belanger, S.3
  • 46
    • 0346095210 scopus 로고    scopus 로고
    • The insulin receptor isoform exon11- (IR-A) in cancer and other diseases: A review
    • Denley A, Wallace JC, Cosgrove LJ, Forbes BE. The insulin receptor isoform exon11- (IR-A) in cancer and other diseases: a review. Horm Metab Res 2003;35: 778-85.
    • (2003) Horm Metab Res , vol.35 , pp. 778-785
    • Denley, A.1    Wallace, J.C.2    Cosgrove, L.J.3    Forbes, B.E.4
  • 47
    • 38949108241 scopus 로고    scopus 로고
    • Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies
    • Renehan AG,Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 2008;371:569-78.
    • (2008) Lancet , vol.371 , pp. 569-578
    • Renehan, A.G.1    Tyson, M.2    Egger, M.3    Heller, R.F.4    Zwahlen, M.5
  • 48
    • 38449105596 scopus 로고    scopus 로고
    • Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts
    • Venkateswaran V, Haddad AQ, Fleshner NE, et al. Association of diet-induced hyperinsulinemia with accelerated growth of prostate cancer (LNCaP) xenografts. J Natl Cancer Inst 2007;99:1793-800.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 1793-1800
    • Venkateswaran, V.1    Haddad, A.Q.2    Fleshner, N.E.3
  • 49
    • 34248170187 scopus 로고    scopus 로고
    • Functional responses and in vivo antitumor activity of h7C10: A humanised monoclonal antibody with neutralising activity against the insulinlike growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors
    • Pandini G, Wurch T, Akla B, Corvaia N, Belfiore A, Goetsch L. Functional responses and in vivo antitumor activity of h7C10: a humanised monoclonal antibody with neutralising activity against the insulinlike growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors. Eur J Cancer 2007;43:1318-27.
    • (2007) Eur J Cancer , vol.43 , pp. 1318-1327
    • Pandini, G.1    Wurch, T.2    Akla, B.3    Corvaia, N.4    Belfiore, A.5    Goetsch, L.6
  • 50
    • 0024460381 scopus 로고
    • Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice
    • Arteaga CL, Kitten LJ, Coronado EB, et al. Blockade of the type I somatomedin receptor inhibits growth of human breast cancer cells in athymic mice. J Clin Invest 1989;84:1418-23.
    • (1989) J Clin Invest , vol.84 , pp. 1418-1423
    • Arteaga, C.L.1    Kitten, L.J.2    Coronado, E.B.3
  • 51
    • 0036782071 scopus 로고    scopus 로고
    • Structural biology of insulin and IGF1 receptors: Implications for drug design
    • De Meyts P, Whittaker J. Structural biology of insulin and IGF1 receptors: implications for drug design. Nat Rev Drug Discov 2002;1:769-83.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 769-783
    • De Meyts, P.1    Whittaker, J.2
  • 52
    • 41149097757 scopus 로고    scopus 로고
    • Engineering therapeutic monoclonal antibodies
    • Liu XY, Pop LM, Vitetta ES. Engineering therapeutic monoclonal antibodies. Immunol Rev 2008;222:9-27.
    • (2008) Immunol Rev , vol.222 , pp. 9-27
    • Liu, X.Y.1    Pop, L.M.2    Vitetta, E.S.3
  • 53
    • 35148901539 scopus 로고    scopus 로고
    • CNS response after erlotinib therapy in a patient with metastatic NSCLC with an EGFR mutation
    • Pan M, Santamaria M,Wollman DB CNS response after erlotinib therapy in a patient with metastatic NSCLC with an EGFR mutation. Nat Clin Pract Oncol 2007;4:603-7.
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 603-607
    • Pan, M.1    Santamaria, M.2    Wollman, D.B.3
  • 54
    • 33644555493 scopus 로고    scopus 로고
    • Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor: Implications for anti-insulin-like growth factor therapy in breast cancer
    • Sachdev D, Singh R, Fujita-Yamaguchi Y, Yee D Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor: implications for anti-insulin-like growth factor therapy in breast cancer. Cancer Res 2006;66:2391-402.
    • (2006) Cancer Res , vol.66 , pp. 2391-2402
    • Sachdev, D.1    Singh, R.2    Fujita-Yamaguchi, Y.3    Yee, D.4
  • 55
    • 34848845313 scopus 로고    scopus 로고
    • Modifying IGF1 activity: An approach to treat endocrine disorders, atherosclerosis and cancer
    • Clemmons DR. Modifying IGF1 activity: an approach to treat endocrine disorders, atherosclerosis and cancer. Nat Rev Drug Discov 2007;6:821 -33.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 821-833
    • Clemmons, D.R.1
  • 56
    • 35348815620 scopus 로고    scopus 로고
    • Phase I dose escalation studyof theanti-insulin-likegrowth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors
    • Haluska P, Shaw HM, Batzel GN, et al. Phase I dose escalation studyof theanti-insulin-likegrowth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors. Clin Cancer Res 2007;13:5834-40.
    • (2007) Clin Cancer Res , vol.13 , pp. 5834-5840
    • Haluska, P.1    Shaw, H.M.2    Batzel, G.N.3
  • 57
    • 54349107362 scopus 로고    scopus 로고
    • High activity of the anti-IGF-1R antibody CP-751,871 in combination with paclitaxel and carboplatin in squamous NSCLC
    • abstr 8015, May 20
    • Karp DD, Paz-Ares LG, Novello S, et al. High activity of the anti-IGF-1R antibody CP-751,871 in combination with paclitaxel and carboplatin in squamous NSCLC. J Clin Oncol 26: 2008 (May 20 suppl: abstr 8015).
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Karp, D.D.1    Paz-Ares, L.G.2    Novello, S.3
  • 58
    • 56149094007 scopus 로고    scopus 로고
    • AphaseI B study of AMG 479, a type1 insulin-like growth factor receptor (IGF1R) antibody, in combination with pani-tumumab (P) or gemcitabline (G)
    • abstr 3583, May 20
    • Sarantopoulos J, Mita AC, MulayM,et al. AphaseI B study of AMG 479, a type1 insulin-like growth factor receptor (IGF1R) antibody, in combination with pani-tumumab (P) or gemcitabline (G). J Clin Oncol 26:2008 (May 20 suppl; abstr 3583).
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Sarantopoulos, J.1    Mita, A.C.2    MulayM3
  • 59
    • 49249125421 scopus 로고    scopus 로고
    • Phase I, Phar-macokinetic and pharmacodynamic study of the anti-insulinlike growth factor type 1 receptor monoclonal antibody CP-751,871 in patients with multiple myeloma
    • Lacy MQ, Alsina M, Fonseca R, et al. Phase I, Phar-macokinetic and pharmacodynamic study of the anti-insulinlike growth factor type 1 receptor monoclonal antibody CP-751,871 in patients with multiple myeloma. JClinOncol2008;26:3196-203.
    • JClinOncol2008;26 , pp. 3196-3203
    • Lacy, M.Q.1    Alsina, M.2    Fonseca, R.3
  • 60
    • 61349083798 scopus 로고    scopus 로고
    • GualbertoA,MelvinCL,DeanA,et al.Characterization of NSLC patients responding to anti-IGF-1R therapy. J Clin Oncol 26: 2008(May20suppl;abstr8000).
    • GualbertoA,MelvinCL,DeanA,et al.Characterization of NSLC patients responding to anti-IGF-1R therapy. J Clin Oncol 26: 2008(May20suppl;abstr8000).
  • 61
    • 61349164421 scopus 로고    scopus 로고
    • Tolcher AW, Rothenberg ML, Rodon J, et al. Aphase I pharmacokinetic and pharmacodynamic study of AMG 479, a fully human monoclonal antibody against insulin-like growth factor type 1 receptor (IGF-1R), in advanced solid tumors. J Clin Oncol 2007 ASCO Annual Meeting Proceedings Part I.25, no18S June
    • Tolcher AW, Rothenberg ML, Rodon J, et al. Aphase I pharmacokinetic and pharmacodynamic study of AMG 479, a fully human monoclonal antibody against insulin-like growth factor type 1 receptor (IGF-1R), in advanced solid tumors. J Clin Oncol 2007 ASCO Annual Meeting Proceedings Part I.Vol 25, no18S (June
  • 62
    • 61349143856 scopus 로고    scopus 로고
    • Supplement, 2007:3002
    • Supplement, 2007:3002).
  • 63
    • 61349143271 scopus 로고    scopus 로고
    • Higano CS,Yu EY,Whiting SH, et al. A phase I, first in man study of weekly IMC-A12, a fully human insulin-like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors. J Clin Oncol 2007 ASCO Annual Meeting Proceedings Part I. 25, no 18S (June 20 Supplement), 2007:3505.
    • Higano CS,Yu EY,Whiting SH, et al. A phase I, first in man study of weekly IMC-A12, a fully human insulin-like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors. J Clin Oncol 2007 ASCO Annual Meeting Proceedings Part I. Vol 25, no 18S (June 20 Supplement), 2007:3505.
  • 64
    • 38549094538 scopus 로고    scopus 로고
    • A pilot dose-escalation study of the effects of nordihydro-guareacetic acid on hormone and prostate specific antigen levels in patients with relapsed prostate cancer
    • Ryan CJ, Harzstark AH, Rosenberg J, et al. A pilot dose-escalation study of the effects of nordihydro-guareacetic acid on hormone and prostate specific antigen levels in patients with relapsed prostate cancer. BJU Int 2008;101:436 -9.
    • (2008) BJU Int , vol.101 , pp. 436-439
    • Ryan, C.J.1    Harzstark, A.H.2    Rosenberg, J.3
  • 65
    • 61349192732 scopus 로고    scopus 로고
    • Tolcher AW, Patnaik A, Till E, et al. A phase I
    • Tolcher AW, Patnaik A, Till E, et al. A phase I
  • 66
    • 61349191159 scopus 로고    scopus 로고
    • study of AVE-1642, a humanized monoclonal antibody IGF-1R (insulin like growth factor 1 receptor) antagonist, in patients (pts) with advanced solid tumor (T). J Clin Oncol 26: 2008 (May 20 suppl; abstr 3582).
    • study of AVE-1642, a humanized monoclonal antibody IGF-1R (insulin like growth factor 1 receptor) antagonist, in patients (pts) with advanced solid tumor (T). J Clin Oncol 26: 2008 (May 20 suppl; abstr 3582).
  • 67
    • 54349109725 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and preliminary activity of the anti-IGF-1R antibody CP-751,871 in patients with sarcoma
    • abstr 105010, May 20
    • Olmos D, Okuno S, Schuetze SM, et al. Safety, pharmacokinetics and preliminary activity of the anti-IGF-1R antibody CP-751,871 in patients with sarcoma. J Clin Oncol 26: 2008 (May 20 suppl; abstr 105010).
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL.
    • Olmos, D.1    Okuno, S.2    Schuetze, S.M.3
  • 68
    • 56149086171 scopus 로고    scopus 로고
    • A phase I, pharmacokinetic (PK) and pharmacody-namic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor-1 receptor (IGF1R) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors
    • Atzori F, Tabernero J, Cervantes A, et al. A phase I, pharmacokinetic (PK) and pharmacody-namic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor-1 receptor (IGF1R) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors. J Clin Oncol 2008;26:3519.
    • (2008) J Clin Oncol , vol.26 , pp. 3519
    • Atzori, F.1    Tabernero, J.2    Cervantes, A.3
  • 69
    • 61349119513 scopus 로고    scopus 로고
    • Toretsky JA, Kalebic T, Blakesley V, LeRoith D
    • Toretsky JA, Kalebic T, Blakesley V, LeRoith D,
  • 70
    • 0030695913 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts
    • Helman LJ. The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts. J Biol Chem 1997;272:30822-7.
    • (1997) J Biol Chem , vol.272 , pp. 30822-30827
    • Helman, L.J.1
  • 72
    • 3543026281 scopus 로고    scopus 로고
    • factor binding protein 3. Mol Cell Biol 2004;24: 7275-83.
    • factor binding protein 3. Mol Cell Biol 2004;24: 7275-83.
  • 73
    • 42049092980 scopus 로고    scopus 로고
    • Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells
    • GrahamTR, Zhau HE, Odero-Marah VA, et al. Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells. Cancer Res 2008;68:2479-88.
    • (2008) Cancer Res , vol.68 , pp. 2479-2488
    • Graham, T.R.1    Zhau, H.E.2    Odero-Marah, V.A.3
  • 74
    • 42049116522 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells
    • Fuchs BC, Fujii T, Dorfman JD, et al. Epithelial-to-mesenchymal transition and integrin-linked kinase mediate sensitivity to epidermal growth factor receptor inhibition in human hepatoma cells. Cancer Res 2008;68:2391 -9.
    • (2008) Cancer Res , vol.68 , pp. 2391-2399
    • Fuchs, B.C.1    Fujii, T.2    Dorfman, J.D.3
  • 75
    • 38849122572 scopus 로고    scopus 로고
    • Incorporating molecular tools into early-stage clinical trials
    • Weil RJ. Incorporating molecular tools into early-stage clinical trials. PLoS Med 2008;5:e21.
    • (2008) PLoS Med , vol.5
    • Weil, R.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.