메뉴 건너뛰기




Volumn 12, Issue 2, 2012, Pages 89-103

Targeting MET in cancer: Rationale and progress

Author keywords

[No Author keywords available]

Indexed keywords

BMS 777607; CABOZANTINIB; CRIZOTINIB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; FOCAL ADHESION KINASE; LAPATINIB; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; PLACEBO; RILOTUMUMAB; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SOMATOMEDIN C RECEPTOR; TIVANTINIB; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR; WNT PROTEIN; WNT7B PROTEIN;

EID: 84856152266     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3205     Document Type: Review
Times cited : (1217)

References (187)
  • 1
    • 0021241398 scopus 로고
    • Molecular cloning of a new transforming gene from a chemically transformed human cell line
    • Cooper, C. S. et al. Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature 311, 29-33 (1984). (Pubitemid 14065275)
    • (1984) Nature , vol.311 , Issue.5981 , pp. 29-33
    • Cooper, C.S.1    Park, M.2    Blair, D.G.3
  • 5
    • 0023668638 scopus 로고
    • And subunit structure of hepatocyte growth factor from rat platelets
    • Nakamura, T., Nawa, K., Ichihara, A., Kaise, N. & Nishino, T. Purification and subunit structure of hepatocyte growth factor from rat platelets. FEBS Lett. 224, 311-316 (1987).
    • (1987) FEBS Lett. , vol.224 , pp. 311-316
    • Nakamura, T.1    Nawa, K.2    Ichihara, A.3    Kaise, N.4    Purification, N.T.5
  • 7
    • 0024356856 scopus 로고
    • Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes
    • Zarnegar, R. & Michalopoulos, G. Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes. Cancer Res. 49, 3314-3320 (1989). (Pubitemid 19162144)
    • (1989) Cancer Research , vol.49 , Issue.12 , pp. 3314-3320
    • Zarnegar, R.1    Michalopoulos, G.2
  • 8
    • 0023661693 scopus 로고
    • Scatter factor is a fibroblast-derived modulator of epithelial cell mobility
    • Stoker, M., Gherardi, E., Perryman, M. & Gray, J. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 327, 239-242 (1987). (Pubitemid 17071053)
    • (1987) Nature , vol.326 , Issue.6119 , pp. 239-242
    • Stoker, M.1    Gherardi, E.2    Perryman, M.3    Gray, J.4
  • 10
    • 0025351332 scopus 로고
    • Hepatocytes and scatter factor
    • Gherardi, E. & Stoker, M. Hepatocytes and scatter factor. Nature 346, 228 (1990). (Pubitemid 20227395)
    • (1990) Nature , vol.346 , Issue.6281 , pp. 228
    • Gherard, E.1    Stoker, M.2
  • 13
    • 0028899952 scopus 로고
    • Scatter factor/hepatocyte growth factor is essential for liver development
    • Schmidt, C. et al. Scatter factor/hepatocyte growth factor is essential for liver development. Nature 373, 699-702 (1995).
    • (1995) Nature , vol.373 , pp. 699-702
    • Schmidt, C.1
  • 14
    • 0028911690 scopus 로고
    • Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
    • Uehara, Y. et al. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature 373, 702-705 (1995).
    • (1995) Nature , vol.373 , pp. 702-705
    • Uehara, Y.1
  • 15
    • 0029134104 scopus 로고
    • Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
    • Bladt, F., Riethmacher, D., Isenmann, S., Aguzzi, A. & Birchmeier, C. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature 376, 768-771 (1995).
    • (1995) Nature , vol.376 , pp. 768-771
    • Bladt, F.1    Riethmacher, D.2    Isenmann, S.3    Aguzzi, A.4    Birchmeier, C.5
  • 17
    • 0029855280 scopus 로고    scopus 로고
    • Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
    • DOI 10.1038/384173a0
    • Weidner, K. M. et al. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 384, 173-176 (1996). (Pubitemid 26386473)
    • (1996) Nature , vol.384 , Issue.6605 , pp. 173-176
    • Weidner, K.M.1    Di Cesare, S.2    Sachs, M.3    Brinkmann, V.4    Behrens, J.5    Birchmeier, W.6
  • 18
    • 70349329537 scopus 로고    scopus 로고
    • Crosstalk in Met receptor oncogenesis
    • Lai, A. Z., Abella, J. V. & Park, M. Crosstalk in Met receptor oncogenesis. Trends Cell Biol. 19, 542-551 (2009).
    • (2009) Trends Cell Biol. , vol.19 , pp. 542-551
    • Lai, A.Z.1    Abella, J.V.2    Park, M.3
  • 19
    • 78649420006 scopus 로고    scopus 로고
    • MET signalling: Principles and functions in development, organ regeneration and cancer
    • Trusolino, L., Bertotti, A. & Comoglio, P. M. MET signalling: principles and functions in development, organ regeneration and cancer. Nature Rev. Mol. Cell Biol. 11, 834-848 (2010).
    • (2010) Nature Rev. Mol. Cell Biol. , vol.11 , pp. 834-848
    • Trusolino, L.1    Bertotti, A.2    Comoglio, P.M.3
  • 22
    • 33645235265 scopus 로고    scopus 로고
    • Structural basis of hepatocyte growth factor/scatter factor and MET signalling
    • Gherardi, E. et al. Structural basis of hepatocyte growth factor/scatter factor and MET signalling. Proc. Natl Acad. Sci. USA 103, 4046-4051 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 4046-4051
    • Gherardi, E.1
  • 24
    • 76549122581 scopus 로고    scopus 로고
    • Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA
    • Owen, K. A. et al. Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA. Biochem. J. 426, 219-228 (2010).
    • (2010) Biochem. J. , vol.426 , pp. 219-228
    • Owen, K.A.1
  • 32
    • 0032533765 scopus 로고    scopus 로고
    • Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution
    • Ultsch, M., Lokker, N. A., Godowski, P. J. & de Vos, A. M. Crystal structure of the NK1 fragment of human hepatocyte growth factor at 2.0 A resolution. Structure 6, 1383-1393 (1998). (Pubitemid 28541882)
    • (1998) Structure , vol.6 , Issue.11 , pp. 1383-1393
    • Ultsch, M.1    Lokker, N.A.2    Godowski, P.J.3    De Vos, A.M.4
  • 34
    • 3142595278 scopus 로고    scopus 로고
    • Crystal structure of the HGF β-chain in complex with the Sema domain of the Met receptor
    • DOI 10.1038/sj.emboj.7600243
    • Stamos, J., Lazarus, R. A., Yao, X., Kirchhofer, D. & Wiesmann, C. Crystal structure of the HGF β-chain in complex with the Sema domain of the Met receptor. EMBO J. 23, 2325-2335 (2004). (Pubitemid 38954840)
    • (2004) EMBO Journal , vol.23 , Issue.12 , pp. 2325-2335
    • Stamos, J.1    Lazarus, R.A.2    Yao, X.3    Kirchhofer, D.4    Wiesmann, C.5
  • 36
    • 73249142243 scopus 로고    scopus 로고
    • Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB
    • Ferraris, D. M., Gherardi, E., Di, Y., Heinz, D. W. & Niemann, H. H. Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB. J. Mol. Biol. 395, 522-532 (2010).
    • (2010) J. Mol. Biol. , vol.395 , pp. 522-532
    • Ferraris, D.M.1    Gherardi Di E, Y.2    Heinz, D.W.3    Niemann, H.H.4
  • 37
  • 38
    • 0033761488 scopus 로고    scopus 로고
    • The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase
    • Maroun, C. R., Naujokas, M. A., Holgado-Madruga, M., Wong, A. J. & Park, M. The tyrosine phosphatase SHP-2 is required for sustained activation of extracellular signal-regulated kinase and epithelial morphogenesis downstream from the met receptor tyrosine kinase. Mol. Cell. Biol. 20, 8513-8525 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 8513-8525
    • Maroun, C.R.1    Naujokas, M.A.2    Holgado-Madruga, M.3    Wong, A.J.4    Park, M.5
  • 39
    • 66349098064 scopus 로고    scopus 로고
    • Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor
    • Paliouras, G. N., Naujokas, M. A. & Park, M. Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. Mol. Cell. Biol. 29, 3018-3032 (2009).
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 3018-3032
    • Paliouras, G.N.1    Naujokas, M.A.2    Park, M.3
  • 43
    • 59849127924 scopus 로고    scopus 로고
    • Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology
    • Ishibe, S. et al. Met and the epidermal growth factor receptor act cooperatively to regulate final nephron number and maintain collecting duct morphology. Development 136, 337-345 (2009).
    • (2009) Development , vol.136 , pp. 337-345
    • Ishibe, S.1
  • 44
    • 0025824738 scopus 로고
    • Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor
    • Montesano, R., Matsumoto, K., Nakamura, T. & Orci, L. Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell 67, 901-908 (1991). (Pubitemid 121001504)
    • (1991) Cell , vol.67 , Issue.5 , pp. 901-908
    • Montesano, R.1    Matsumoto, K.2    Nakamura, T.3    Orci, L.4
  • 45
    • 0028798286 scopus 로고
    • Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros
    • Woolf, A. S. et al. Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros. J. Cell Biol. 128, 171-184 (1995).
    • (1995) J. Cell Biol. , vol.128 , pp. 171-184
    • Woolf, A.S.1
  • 46
    • 54549102284 scopus 로고    scopus 로고
    • Derailed endocytosis: An emerging feature of cancer
    • Mosesson, Y., Mills, G. B. & Yarden, Y. Derailed endocytosis: an emerging feature of cancer. Nature Rev. Cancer 8, 835-850 (2008).
    • (2008) Nature Rev. Cancer , vol.8 , pp. 835-850
    • Mosesson, Y.1    Mills, G.B.2    Yarden, Y.3
  • 47
    • 79959999334 scopus 로고    scopus 로고
    • A direct role for Met endocytosis in tumorigenesis
    • Joffre, C. et al. A direct role for Met endocytosis in tumorigenesis. Nature Cell Biol. 13, 827-837 (2011).
    • (2011) Nature Cell Biol. , vol.13 , pp. 827-837
    • Joffre, C.1
  • 48
    • 0035930341 scopus 로고    scopus 로고
    • Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein
    • DOI 10.1016/S1097-2765(01)00378-1
    • Peschard, P. et al. Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol. Cell 8, 995-1004 (2001). (Pubitemid 34031802)
    • (2001) Molecular Cell , vol.8 , Issue.5 , pp. 995-1004
    • Peschard, P.1    Fournier, T.M.2    Lamorte, L.3    Naujokas, M.A.4    Band, H.5    Langdon, W.Y.6    Park, M.7
  • 49
    • 0035901973 scopus 로고    scopus 로고
    • Down-regulation of MET, the receptor for hepatocyte growth factor
    • DOI 10.1038/sj.onc.1204475
    • Hammond, D. E., Urbe, S., Vande Woude, G. F. & Clague, M. J. Down-regulation of MET, the receptor for hepatocyte growth factor. Oncogene 20, 2761-2770 (2001). (Pubitemid 32549833)
    • (2001) Oncogene , vol.20 , Issue.22 , pp. 2761-2770
    • Hammond, D.E.1    Urbe, S.2    Vande Woude, G.F.3    Clague, M.J.4
  • 51
    • 27144512084 scopus 로고    scopus 로고
    • Met/hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation
    • DOI 10.1128/MCB.25.21.9632-9645.2005
    • Abella, J. V. et al. Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. Mol. Cell. Biol. 25, 9632-9645 (2005). (Pubitemid 41507861)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.21 , pp. 9632-9645
    • Abella, J.V.1    Peschard, P.2    Naujokas, M.A.3    Lin, T.4    Saucier, C.5    Urbe, S.6    Park, M.7
  • 52
    • 0034641890 scopus 로고    scopus 로고
    • A novel germ line juxtamembrane Met mutation in human gastric cancer
    • Lee, J. H. et al. A novel germ line juxtamembrane Met mutation in human gastric cancer. Oncogene 19, 4947-4953 (2000).
    • (2000) Oncogene , vol.19 , pp. 4947-4953
    • Lee, J.H.1
  • 53
    • 77950859967 scopus 로고    scopus 로고
    • Gastric cancer cell line Hs746T harbors a splice site mutation of c-Met causing juxtamembrane domain deletion
    • Asaoka, Y. et al. Gastric cancer cell line Hs746T harbors a splice site mutation of c-Met causing juxtamembrane domain deletion. Biochem. Biophys. Res. Commun. 394, 1042-1046 (2010).
    • (2010) Biochem. Biophys. Res. Commun. , vol.394 , pp. 1042-1046
    • Asaoka, Y.1
  • 54
    • 65649111648 scopus 로고    scopus 로고
    • Down-regulation of the met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis
    • Foveau, B. et al. Down-regulation of the met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis. Mol. Biol. Cell 20, 2495-2507 (2009).
    • (2009) Mol. Biol. Cell , vol.20 , pp. 2495-2507
    • Foveau, B.1
  • 56
    • 0022891340 scopus 로고
    • Tumors: Wounds that do not heal: Similarities between tumor stroma generation and wound healing
    • Dvorak, H. F. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315, 1650-1659 (1986). (Pubitemid 17052899)
    • (1986) New England Journal of Medicine , vol.315 , Issue.26 , pp. 1650-1659
    • Dvorak, H.F.1
  • 59
    • 1842428601 scopus 로고    scopus 로고
    • Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair
    • Huh, C. G. et al. Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc. Natl Acad. Sci. USA 101, 4477-4482 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 4477-4482
    • Huh, C.G.1
  • 60
    • 0035907041 scopus 로고    scopus 로고
    • β-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
    • DOI 10.1016/S0092-8674(01)00336-1
    • Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G. & Birchmeier, W. β-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 105, 533-545 (2001). (Pubitemid 32520858)
    • (2001) Cell , vol.105 , Issue.4 , pp. 533-545
    • Huelsken, J.1    Vogel, R.2    Erdmann, B.3    Cotsarelis, G.4    Birchmeier, W.5
  • 61
    • 77949360959 scopus 로고    scopus 로고
    • Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin
    • Snippert, H. J. et al. Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science 327, 1385-1389 (2010).
    • (2010) Science , vol.327 , pp. 1385-1389
    • Snippert, H.J.1
  • 64
    • 57149092131 scopus 로고    scopus 로고
    • Expression and mutational analysis of MET in human solid cancers
    • Ma, P. C. et al. Expression and mutational analysis of MET in human solid cancers. Genes Chromosomes Cancer 47, 1025-1037 (2008).
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 1025-1037
    • Ma, P.C.1
  • 66
    • 69149108735 scopus 로고    scopus 로고
    • Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer
    • Ponzo, M. G. et al. Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer. Proc. Natl Acad. Sci. USA 106, 12903-12908 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 12903-12908
    • Ponzo, M.G.1
  • 71
    • 43749091506 scopus 로고    scopus 로고
    • Showering c-MET-dependent cancers with drugs
    • DOI 10.1016/j.gde.2008.02.001, PII S0959437X08000269
    • Knudsen, B. S. & Vande Woude, G. Showering c-MET-dependent cancers with drugs. Curr. Opin. Genet. Dev. 18, 87-96 (2008). (Pubitemid 351694452)
    • (2008) Current Opinion in Genetics and Development , vol.18 , Issue.1 , pp. 87-96
    • Knudsen, B.S.1    Vande Woude, G.2
  • 74
    • 33845713565 scopus 로고    scopus 로고
    • met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells
    • DOI 10.1242/jcs.03236
    • Yamamoto, N., Mammadova, G., Song, R. X., Fukami, Y. & Sato, K. Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells. J. Cell Sci. 119, 4623-4633 (2006). (Pubitemid 44964259)
    • (2006) Journal of Cell Science , vol.119 , Issue.22 , pp. 4623-4633
    • Yamamoto, N.1    Mammadova, G.2    Song, R.X.-D.3    Fukami, Y.4    Sato, K.-I.5
  • 76
    • 73649102105 scopus 로고    scopus 로고
    • Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC
    • Turke, A. B. et al. Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC. Cancer Cell 17, 77-88 (2010).
    • (2010) Cancer Cell , vol.17 , pp. 77-88
    • Turke, A.B.1
  • 77
    • 77956296140 scopus 로고    scopus 로고
    • MET kinase inhibitor SGX523 synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth
    • Zhang, Y. W. et al. MET kinase inhibitor SGX523 synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth. Cancer Res. 70, 6880-6890 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 6880-6890
    • Zhang, Y.W.1
  • 79
    • 71949106010 scopus 로고    scopus 로고
    • Semaphorin 4D signaling requires the recruitment of phospholipase C γ into the plexin-B1 receptor complex
    • Swiercz, J. M., Worzfeld, T. & Offermanns, S. Semaphorin 4D signaling requires the recruitment of phospholipase C γ into the plexin-B1 receptor complex. Mol. Cell. Biol. 29, 6321-6334 (2009).
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 6321-6334
    • Swiercz, J.M.1    Worzfeld, T.2    Offermanns, S.3
  • 80
    • 42549164807 scopus 로고    scopus 로고
    • Wnt signalling and its impact on development and cancer
    • DOI 10.1038/nrc2389, PII NRC2389
    • Klaus, A. & Birchmeier, W. Wnt signalling and its impact on development and cancer. Nature Rev. Cancer 8, 387-398 (2008). (Pubitemid 351589714)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.5 , pp. 387-398
    • Klaus, A.1    Birchmeier, W.2
  • 81
    • 0037105707 scopus 로고    scopus 로고
    • Wnt signaling regulates expression of the receptor tyrosine kinase Met in colorectal cancer
    • Boon, E. M., van der Neut, R., van de Wetering, M., Clevers, H. & Pals, S. T. Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer. Cancer Res. 62, 5126-5128 (2002). (Pubitemid 35024579)
    • (2002) Cancer Research , vol.62 , Issue.18 , pp. 5126-5128
    • Boon, E.M.J.1    Van Der Neut, R.2    Van De Wetering, M.3    Clevers, H.4    Pals, S.T.5
  • 82
    • 65549125978 scopus 로고    scopus 로고
    • Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis
    • Liu, Y. et al. Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis. Development 136, 843-853 (2009).
    • (2009) Development , vol.136 , pp. 843-853
    • Liu, Y.1
  • 86
    • 33646148495 scopus 로고    scopus 로고
    • Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases
    • Sridhar, S. C. & Miranti, C. K. Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases. Oncogene 25, 2367-2378 (2006).
    • (2006) Oncogene , vol.25 , pp. 2367-2378
    • Sridhar, S.C.1    Miranti, C.K.2
  • 87
    • 34648831077 scopus 로고    scopus 로고
    • Regulation of c-Met signaling by the tetraspanin KAI-1/CD82 affects cancer cell migration
    • DOI 10.1002/ijc.22887
    • Takahashi, M., Sugiura, T., Abe, M., Ishii, K. & Shirasuna, K. Regulation of c-Met signaling by the tetraspanin KAI-1/CD82 affects cancer cell migration. Int. J. Cancer 121, 1919-1929 (2007). (Pubitemid 47463154)
    • (2007) International Journal of Cancer , vol.121 , Issue.9 , pp. 1919-1929
    • Takahashi, M.1    Sugiura, T.2    Abe, M.3    Ishii, K.4    Shirasuna, K.5
  • 89
    • 27644543354 scopus 로고    scopus 로고
    • Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis
    • DOI 10.1215/S1152851705000050
    • Abounader, R. & Laterra, J. Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis. Neuro Oncol. 7, 436-451 (2005). (Pubitemid 41555616)
    • (2005) Neuro-Oncology , vol.7 , Issue.4 , pp. 436-451
    • Abounader, R.1    Laterra, J.2
  • 90
    • 0026722243 scopus 로고
    • Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth
    • Bussolino, F. et al. Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J. Cell Biol. 119, 629-641 (1992).
    • (1992) J. Cell Biol. , vol.119 , pp. 629-641
    • Bussolino, F.1
  • 93
    • 70149095573 scopus 로고    scopus 로고
    • Cross-talk between the VEGF-A and HGF signalling pathways in endothelial cells
    • Sulpice, E. et al. Cross-talk between the VEGF-A and HGF signalling pathways in endothelial cells. Biol. Cell 101, 525-539 (2009).
    • (2009) Biol. Cell , vol.101 , pp. 525-539
    • Sulpice, E.1
  • 95
    • 77957119630 scopus 로고    scopus 로고
    • Cell delivery of Met docking site peptides inhibit angiogenesis and vascular tumor growth
    • Cantelmo, A. R. et al. Cell delivery of Met docking site peptides inhibit angiogenesis and vascular tumor growth. Oncogene 29, 5286-5298 (2010).
    • (2010) Oncogene , vol.29 , pp. 5286-5298
    • Cantelmo, A.R.1
  • 96
    • 33745354482 scopus 로고    scopus 로고
    • Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1α in human salivary gland cancer cells
    • DOI 10.1016/j.oraloncology.2005.10.016, PII S1368837505003003
    • Hara, S. et al. Hypoxia enhances c-Met/HGF receptor expression and signaling by activating HIF-1α in human salivary gland cancer cells. Oral Oncol. 42, 593-598 (2006). (Pubitemid 43947665)
    • (2006) Oral Oncology , vol.42 , Issue.6 , pp. 593-598
    • Hara, S.1    Nakashiro, K.-i.2    Klosek, S.K.3    Ishikawa, T.4    Shintani, S.5    Hamakawa, H.6
  • 97
    • 33751569391 scopus 로고    scopus 로고
    • Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway
    • DOI 10.1002/ijc.22178
    • Ide, T. et al. Tumor-stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway. Int. J. Cancer 119, 2750-2759 (2006). (Pubitemid 44846225)
    • (2006) International Journal of Cancer , vol.119 , Issue.12 , pp. 2750-2759
    • Ide, T.1    Kitajima, Y.2    Miyoshi, A.3    Ohtsuka, T.4    Mitsuno, M.5    Ohtaka, K.6    Koga, Y.7    Miyazaki, K.8
  • 98
    • 0037478437 scopus 로고    scopus 로고
    • Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
    • DOI 10.1016/S1535-6108(03)00085-0, PII S1535610803000850
    • Pennacchietti, S. et al. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 3, 347-361 (2003). (Pubitemid 38340304)
    • (2003) Cancer Cell , vol.3 , Issue.4 , pp. 347-361
    • Pennacchietti, S.1    Michieli, P.2    Galluzzo, M.3    Mazzone, M.4    Giordano, S.5    Comoglio, P.M.6
  • 99
    • 1542345403 scopus 로고    scopus 로고
    • Increased expression of Met protein is associated with up-regulation of hypoxia inducible factor-I (HIF-I) in tumour cells in papillary carcinoma of the thyroid
    • DOI 10.1002/path.1522
    • Scarpino, S. et al. Increased expression of Met protein is associated with up-regulation of hypoxia inducible factor-1 (HIF-1) in tumour cells in papillary carcinoma of the thyroid. J. Pathol. 202, 352-358 (2004). (Pubitemid 38325245)
    • (2004) Journal of Pathology , vol.202 , Issue.3 , pp. 352-358
    • Scarpino, S.1    D'Alena, F.C.2    Di Napoli, A.3    Pasquini, A.4    Marzullo, A.5    Ruco, L.P.6
  • 100
    • 70350230210 scopus 로고    scopus 로고
    • Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases
    • Qian, F. et al. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res. 69, 8009-8016 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 8009-8016
    • Qian, F.1
  • 101
    • 71849098261 scopus 로고    scopus 로고
    • E7050: A dual c-Met and VEGFR-2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft models
    • Nakagawa, T. et al. E7050: a dual c-Met and VEGFR-2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft models. Cancer Sci. 101, 210-215 (2010).
    • (2010) Cancer Sci. , vol.101 , pp. 210-215
    • Nakagawa, T.1
  • 102
    • 58149346173 scopus 로고    scopus 로고
    • The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis
    • You, W. K. & McDonald, D. M. The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis. BMB Rep. 41, 833-839 (2008).
    • (2008) BMB Rep. , vol.41 , pp. 833-839
    • You, W.K.1    McDonald, D.M.2
  • 103
    • 0032495573 scopus 로고    scopus 로고
    • Role of morphogenetic factors in metastasis of mammary carcinoma cells
    • Meiners, S., Brinkmann, V., Naundorf, H. & Birchmeier, W. Role of morphogenetic factors in metastasis of mammary carcinoma cells. Oncogene 16, 9-20 (1998). (Pubitemid 28043504)
    • (1998) Oncogene , vol.16 , Issue.1 , pp. 9-20
    • Meiners, S.1    Brinkmann, V.2    Naundorf, H.3    Birchmeier, W.4
  • 104
    • 0346122895 scopus 로고    scopus 로고
    • Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways
    • DOI 10.1038/sj.onc.1207063
    • Gallego, M. I., Bierie, B. & Hennighausen, L. Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways. Oncogene 22, 8498-8508 (2003). (Pubitemid 37523901)
    • (2003) Oncogene , vol.22 , Issue.52 , pp. 8498-8508
    • Gallego, M.I.1    Bierie, B.2    Hennighausen, L.3
  • 108
    • 0022377328 scopus 로고
    • Harvey ras induction of metastatic potential depends upon oncogene activation and the type of recipient cell
    • Muschel, R. J., Williams, J. E., Lowy, D. R. & Liotta, L. A. Harvey ras induction of metastatic potential depends upon oncogene activation and the type of recipient cell. Am. J. Pathol. 121, 1-8 (1985). (Pubitemid 16232385)
    • (1985) American Journal of Pathology , vol.121 , Issue.1 , pp. 1-8
    • Muschel, R.J.1    Williams, J.E.2    Lowy, D.R.3    Liotta, L.A.4
  • 110
    • 0028894787 scopus 로고
    • Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells
    • Ridley, A. J., Comoglio, P. M. & Hall, A. Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells. Mol. Cell. Biol. 15, 1110-1122 (1995).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 1110-1122
    • Ridley, A.J.1    Comoglio, P.M.2    Hall, A.3
  • 111
    • 77951975325 scopus 로고    scopus 로고
    • Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
    • Vermeulen, L. et al. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nature Cell Biol. 12, 468-476 (2010).
    • (2010) Nature Cell Biol. , vol.12 , pp. 468-476
    • Vermeulen, L.1
  • 112
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • DOI 10.1038/nm0797-730
    • Bonnet, D. & Dick, J. E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Med. 3, 730-737 (1997). (Pubitemid 27298715)
    • (1997) Nature Medicine , vol.3 , Issue.7 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 113
    • 34547113747 scopus 로고    scopus 로고
    • Tumor growth need not be driven by rare cancer stem cells
    • DOI 10.1126/science.1142596
    • Kelly, P. N., Dakic, A., Adams, J. M., Nutt, S. L. & Strasser, A. Tumor growth need not be driven by rare cancer stem cells. Science 317, 337 (2007). (Pubitemid 47106366)
    • (2007) Science , vol.317 , Issue.5836 , pp. 337
    • Kelly, P.N.1    Dakic, A.2    Adams, J.M.3    Nutt, S.L.4    Strasser, A.5
  • 114
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/β-catenin signaling in development and disease
    • Clevers, H. Wnt/β-catenin signaling in development and disease. Cell 127, 469-480 (2006).
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 118
    • 2942583980 scopus 로고    scopus 로고
    • Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing
    • Neuss, S., Becher, E., Woltje, M., Tietze, L. & Jahnen-Dechent, W. Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing. Stem Cells 22, 405-414 (2004). (Pubitemid 38736624)
    • (2004) Stem Cells , vol.22 , Issue.3 , pp. 405-414
    • Neuss, S.1    Becher, E.2    Woltje, M.3    Tietze, L.4    Jahnen-Dechent, W.5
  • 119
    • 33749078198 scopus 로고    scopus 로고
    • Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases
    • Son, B. R. et al. Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases. Stem Cells 24, 1254-1264 (2006).
    • (2006) Stem Cells , vol.24 , pp. 1254-1264
    • Son, B.R.1
  • 120
    • 78751565017 scopus 로고    scopus 로고
    • Enhanced c-Met activity promotes G.-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling
    • Tesio, M. et al. Enhanced c-Met activity promotes G.-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling. Blood 117, 419-428.
    • Blood , vol.117 , pp. 419-428
    • Tesio, M.1
  • 122
    • 0032006325 scopus 로고    scopus 로고
    • HGF/SF is present in normal adult skeletal muscle and is capable of activating satellite cells
    • DOI 10.1006/dbio.1997.8803
    • Tatsumi, R., Anderson, J. E., Nevoret, C. J., Halevy, O. & Allen, R. E. HGF/SF is present in normal adult skeletal muscle and is capable of activating satellite cells. Dev. Biol. 194, 114-128 (1998). (Pubitemid 28115263)
    • (1998) Developmental Biology , vol.194 , Issue.1 , pp. 114-128
    • Tatsumi, R.1    Anderson, J.E.2    Nevoret, C.J.3    Halevy, O.4    Allen, R.E.5
  • 123
    • 32844471999 scopus 로고    scopus 로고
    • Identification and differentiation of hepatic stem cells during liver development
    • Kamiya, A., Gonzalez, F. J. & Nakauchi, H. Identification and differentiation of hepatic stem cells during liver development. Front. Biosci. 11, 1302-1310 (2006). (Pubitemid 43253423)
    • (2006) Frontiers in Bioscience , vol.11 , Issue.2 , pp. 1302-1310
    • Kamiya, A.1    Gonzalez, F.J.2    Nakauchi, H.3
  • 124
    • 3242784831 scopus 로고    scopus 로고
    • Prospective isolation of multipotent pancreatic progenitors using flow-cytometric cell sorting
    • DOI 10.2337/diabetes.53.8.2143
    • Suzuki, A., Nakauchi, H. & Taniguchi, H. Prospective isolation of multipotent pancreatic progenitors using flow-cytometric cell sorting. Diabetes 53, 2143-2152 (2004). (Pubitemid 38970768)
    • (2004) Diabetes , vol.53 , Issue.8 , pp. 2143-2152
    • Suzuki, A.1    Nakauchi, H.2    Taniguchi, H.3
  • 125
    • 59049106578 scopus 로고    scopus 로고
    • Crypt stem cells as the cells-of-origin of intestinal cancer
    • Barker, N. et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457, 608-611 (2009).
    • (2009) Nature , vol.457 , pp. 608-611
    • Barker, N.1
  • 126
    • 77952581424 scopus 로고    scopus 로고
    • Interaction between human-breast cancer metastasis and bone microenvironment through activated hepatocyte growth factor/Met and β-catenin/Wnt pathways
    • Previdi, S. et al. Interaction between human-breast cancer metastasis and bone microenvironment through activated hepatocyte growth factor/Met and β-catenin/Wnt pathways. Eur. J. Cancer 46, 1679-1691 (2010).
    • (2010) Eur. J. Cancer , vol.46 , pp. 1679-1691
    • Previdi, S.1
  • 127
    • 2442513981 scopus 로고    scopus 로고
    • The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients
    • DOI 10.1038/sj.bjc.6601718
    • Masuya, D. et al. The tumour-stromal interaction between intratumoral c-Met and stromal hepatocyte growth factor associated with tumour growth and prognosis in non-small-cell lung cancer patients. Br. J. Cancer 90, 1555-1562 (2004). (Pubitemid 38648238)
    • (2004) British Journal of Cancer , vol.90 , Issue.8 , pp. 1555-1562
    • Masuya, D.1    Huang, C.2    Liu, D.3    Nakashima, T.4    Kameyama, K.5    Haba, R.6    Ueno, M.7    Yokomise, H.8
  • 128
    • 78649456121 scopus 로고    scopus 로고
    • The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas
    • Mahtouk, K., Tjin, E. P., Spaargaren, M. & Pals, S. T. The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas. Biochim. Biophys. Acta 1806, 208-219 (2010).
    • (2010) Biochim. Biophys. Acta , vol.1806 , pp. 208-219
    • Mahtouk, K.1    Tjin, E.P.2    Spaargaren, M.3    Pals, S.T.4
  • 130
    • 13844296946 scopus 로고    scopus 로고
    • Conformational lability in serine protease active sites: Structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B
    • DOI 10.1016/j.jmb.2004.12.048
    • Shia, S. et al. Conformational lability in serine protease active sites: structures of Hepatocyte Growth Factor Activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B. J. Mol. Biol. 346, 1335-1349 (2005). (Pubitemid 40248833)
    • (2005) Journal of Molecular Biology , vol.346 , Issue.5 , pp. 1335-1349
    • Shia, S.1    Stamos, J.2    Kirchhofer, D.3    Fan, B.4    Wu, J.5    Corpuz, R.T.6    Santell, L.7    Lazarus, R.A.8    Eigenbrot, C.9
  • 131
    • 70350523855 scopus 로고    scopus 로고
    • Pegylated kunitz domain inhibitor suppresses hepsin-mediated invasive tumor growth and metastasis
    • Li, W. et al. Pegylated kunitz domain inhibitor suppresses hepsin-mediated invasive tumor growth and metastasis. Cancer Res. 69, 8395-8402 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 8395-8402
    • Li, W.1
  • 132
    • 38049174343 scopus 로고    scopus 로고
    • Structural insight into distinct mechanisms of protease inhibition by antibodies
    • Wu, Y. et al. Structural insight into distinct mechanisms of protease inhibition by antibodies. Proc. Natl Acad. Sci. USA 104, 19784-19789 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 19784-19789
    • Wu, Y.1
  • 133
    • 71049189254 scopus 로고    scopus 로고
    • Unraveling the allosteric mechanism of serine protease inhibition by an antibody
    • Ganesan, R. et al. Unraveling the allosteric mechanism of serine protease inhibition by an antibody. Structure 17, 1614-1624 (2009).
    • (2009) Structure , vol.17 , pp. 1614-1624
    • Ganesan, R.1
  • 134
    • 34248583079 scopus 로고    scopus 로고
    • The Mechanism of Inhibition of Antibody-based Inhibitors of Membrane-type Serine Protease 1 (MT-SP1)
    • DOI 10.1016/j.jmb.2007.03.078, PII S0022283607004536
    • Farady, C. J., Sun, J., Darragh, M. R., Miller, S. M. & Craik, C. S. The mechanism of inhibition of antibody-based inhibitors of membrane-type serine protease 1 (MT-SP1). J. Mol. Biol. 369, 1041-1051 (2007). (Pubitemid 46754067)
    • (2007) Journal of Molecular Biology , vol.369 , Issue.4 , pp. 1041-1051
    • Farady, C.J.1    Sun, J.2    Darragh, M.R.3    Miller, S.M.4    Craik, C.S.5
  • 136
    • 76649131263 scopus 로고    scopus 로고
    • Biochemical characterization of AMG 102: A neutralizing, fully human monoclonal antibody to human and nonhuman primate hepatocyte growth factor
    • Burgess, T. L. et al. Biochemical characterization of AMG 102: a neutralizing, fully human monoclonal antibody to human and nonhuman primate hepatocyte growth factor. Mol. Cancer Ther. 9, 400-409 (2010).
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 400-409
    • Burgess, T.L.1
  • 137
    • 0031911137 scopus 로고    scopus 로고
    • NK1, a natural splice variant of hepatocyte growth factor/scatter factor, is a partial agonist in vivo
    • Jakubczak, J. L., LaRochelle, W. J. & Merlino, G. NK1, a natural splice variant of hepatocyte growth factor/scatter factor, is a partial agonist in vivo. Mol. Cell. Biol. 18, 1275-1283 (1998). (Pubitemid 28100891)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.3 , pp. 1275-1283
    • Jakubczak, J.L.1    Larochelle, W.J.2    Merlino, G.3
  • 139
    • 40849135544 scopus 로고    scopus 로고
    • Engineering the NK1 fragment of hepatocyte growth factor/scatter factor as a MET receptor antagonist
    • Youles, M. et al. Engineering the NK1 fragment of hepatocyte growth factor/scatter factor as a MET receptor antagonist. J. Mol. Biol. 377, 616-622 (2008).
    • (2008) J. Mol. Biol. , vol.377 , pp. 616-622
    • Youles, M.1
  • 140
    • 0033999314 scopus 로고    scopus 로고
    • Disassociation of Met-mediated biological responses in vivo: The natural hepatocyte growth factor/scatter factor splice variant NK2 antagonizes growth but facilitates metastasis
    • DOI 10.1128/MCB.20.6.2055-2065.2000
    • Otsuka, T. et al. Disassociation of met-mediated biological responses in vivo: the natural hepatocyte growth factor/scatter factor splice variant NK2 antagonizes growth but facilitates metastasis. Mol. Cell. Biol. 20, 2055-2065 (2000). (Pubitemid 30123821)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.6 , pp. 2055-2065
    • Otsuka, T.1    Jakubczak, J.2    Vieira, W.3    Bottaro, D.P.4    Breckenridge, D.5    Larochelle, W.J.6    Merlino, G.7
  • 141
    • 0031583998 scopus 로고    scopus 로고
    • HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factore
    • DOI 10.1016/S0014-5793(97)01475-0, PII S0014579397014750
    • Date, K., Matsumoto, K., Shimura, H., Tanaka, M. & Nakamura, T. HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor. FEBS Lett. 420, 1-6 (1997). (Pubitemid 28037188)
    • (1997) FEBS Letters , vol.420 , Issue.1 , pp. 1-6
    • Date, K.1    Matsumoto, K.2    Shimura, H.3    Tanaka, M.4    Nakamura, T.5
  • 142
    • 77950823134 scopus 로고    scopus 로고
    • Anti-cancer approach with NK4: Bivalent action and mechanisms
    • Nakamura, T., Sakai, K. & Matsumoto, K. Anti-cancer approach with NK4: bivalent action and mechanisms. Anticancer Agents Med. Chem. 10, 36-46 (2010).
    • (2010) Anticancer Agents Med. Chem. , vol.10 , pp. 36-46
    • Nakamura, T.1    Sakai, K.2    Matsumoto, K.3
  • 143
    • 3142619403 scopus 로고    scopus 로고
    • The Sema domain of Met is necessary for receptor dimerization and activation
    • DOI 10.1016/j.ccr.2004.06.013, PII S1535610804001801
    • Kong-Beltran, M., Stamos, J. & Wickramasinghe, D. The Sema domain of Met is necessary for receptor dimerization and activation. Cancer Cell 6, 75-84 (2004). (Pubitemid 38903163)
    • (2004) Cancer Cell , vol.6 , Issue.1 , pp. 75-84
    • Kong-Beltran, M.1    Stamos, J.2    Wickramasinghe, D.3
  • 144
    • 49249100382 scopus 로고    scopus 로고
    • MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival
    • Jin, H. et al. MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival. Cancer Res. 68, 4360-4368 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 4360-4368
    • Jin, H.1
  • 145
    • 33645518840 scopus 로고    scopus 로고
    • Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity
    • Petrelli, A. et al. Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity. Proc. Natl Acad. Sci. USA 103, 5090-5095 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 5090-5095
    • Petrelli, A.1
  • 146
    • 77956215845 scopus 로고    scopus 로고
    • A disintegrin and metalloproteinase-10 (ADAM-10) mediates DN30 antibody-induced shedding of the met surface receptor
    • Schelter, F. et al. A disintegrin and metalloproteinase-10 (ADAM-10) mediates DN30 antibody-induced shedding of the met surface receptor. J. Biol. Chem. 285, 26335-26340 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 26335-26340
    • Schelter, F.1
  • 147
    • 78149265959 scopus 로고    scopus 로고
    • Monovalency unleashes the full therapeutic potential of the DN-30 anti-Met antibody
    • Pacchiana, G. et al. Monovalency unleashes the full therapeutic potential of the DN-30 anti-Met antibody. J. Biol. Chem. 285, 36149-36157 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 36149-36157
    • Pacchiana, G.1
  • 149
    • 77950797736 scopus 로고    scopus 로고
    • Discovery of small molecule c-Met inhibitors: Evolution and profiles of clinical candidates
    • Underiner, T. L., Herbertz, T. & Miknyoczki, S. J. Discovery of small molecule c-Met inhibitors: evolution and profiles of clinical candidates. Anticancer Agents Med. Chem. 10, 2188317-2188327 (2010).
    • (2010) Anticancer Agents Med. Chem. , vol.10 , pp. 2188317-2188327
    • Underiner, T.L.1    Herbertz, T.2    Miknyoczki, S.J.3
  • 151
    • 79953213695 scopus 로고    scopus 로고
    • Structural basis for selective small-molecule kinase inhibition of activated c-Met
    • Rickert, K. W. et al. Structural basis for selective small-molecule kinase inhibition of activated c-Met. J. Biol. Chem. 286, 11218-11225 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 11218-11225
    • Rickert, K.W.1
  • 152
    • 73149091443 scopus 로고    scopus 로고
    • SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo
    • Buchanan, S. G. et al. SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol. Cancer Ther. 8, 3181-3190 (2009).
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 3181-3190
    • Buchanan, S.G.1
  • 153
    • 67049134253 scopus 로고    scopus 로고
    • Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors
    • Timofeevski, S. L. et al. Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors. Biochemistry 48, 5339-5349 (2009).
    • (2009) Biochemistry , vol.48 , pp. 5339-5349
    • Timofeevski, S.L.1
  • 154
    • 64349106088 scopus 로고    scopus 로고
    • Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4- ethoxy-1-(4-fluor ophenyl)-2-oxo-1,2-dihydropyridi ne-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily
    • Schroeder, G. M. et al. Discovery of N-(4-(2-amino-3-chloropyridin-4- yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluor ophenyl)-2-oxo-1,2-dihydropyridi ne-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily. J. Med. Chem. 52, 1251-1254 (2009).
    • (2009) J. Med. Chem. , vol.52 , pp. 1251-1254
    • Schroeder, G.M.1
  • 155
    • 52449083151 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of potent c-Met inhibitors
    • D'Angelo, N. D. et al. Design, synthesis, and biological evaluation of potent c-Met inhibitors. J. Med. Chem. 51, 5766-5779 (2008).
    • (2008) J. Med. Chem. , vol.51 , pp. 5766-5779
    • D'Angelo, N.D.1
  • 156
    • 77953458271 scopus 로고    scopus 로고
    • ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity
    • Munshi, N. et al. ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity. Mol. Cancer Ther. 9, 1544-1553 (2010).
    • (2010) Mol. Cancer Ther. , vol.9 , pp. 1544-1553
    • Munshi, N.1
  • 157
    • 79957985551 scopus 로고    scopus 로고
    • Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197
    • Eathiraj, S. et al. Discovery of a novel mode of protein kinase inhibition characterized by the mechanism of inhibition of human mesenchymal-epithelial transition factor (c-Met) protein autophosphorylation by ARQ 197. J. Biol. Chem. 286, 20666-20676 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 20666-20676
    • Eathiraj, S.1
  • 158
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak, E. L. et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N. Engl. J. Med. 363, 1693-1703 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1693-1703
    • Kwak, E.L.1
  • 160
    • 58749106485 scopus 로고    scopus 로고
    • A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings
    • Knudsen, B. S. et al. A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings. Appl. Immunohistochem. Mol. Morphol. 17, 57-67 (2009).
    • (2009) Appl. Immunohistochem. Mol. Morphol. , vol.17 , pp. 57-67
    • Knudsen, B.S.1
  • 162
    • 44849139232 scopus 로고    scopus 로고
    • Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells
    • Mueller, K. L., Hunter, L. A., Ethier, S. P. & Boerner, J. L. Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells. Cancer Res. 68, 3314-3322 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 3314-3322
    • Mueller, K.L.1    Hunter, L.A.2    Ethier, S.P.3    Boerner, J.L.4
  • 163
    • 77749240452 scopus 로고    scopus 로고
    • XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC
    • Zhang, Y., Guessous, F., Kofman, A., Schiff, D. & Abounader, R. XL-184, a MET, VEGFR-2 and RET kinase inhibitor for the treatment of thyroid cancer, glioblastoma multiforme and NSCLC. IDrugs 13, 112-121 (2010).
    • (2010) IDrugs , vol.13 , pp. 112-121
    • Zhang, Y.1    Guessous, F.2    Kofman, A.3    Schiff, D.4    Abounader, R.5
  • 164
    • 77957328515 scopus 로고    scopus 로고
    • MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors
    • Cepero, V. et al. MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors. Cancer Res. 70, 7580-7590 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 7580-7590
    • Cepero, V.1
  • 165
    • 77952612183 scopus 로고    scopus 로고
    • Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition
    • Corso, S. et al. Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition. Mol. Cancer 9, 121 (2010).
    • (2010) Mol. Cancer , vol.9 , pp. 121
    • Corso, S.1
  • 166
    • 79551559942 scopus 로고    scopus 로고
    • Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors
    • Qi, J. et al. Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors. Cancer Res. 71, 1081-1091 (2011).
    • (2011) Cancer Res. , vol.71 , pp. 1081-1091
    • Qi, J.1
  • 167
    • 80052511675 scopus 로고    scopus 로고
    • Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC
    • Spigel DR. et al. Final efficacy results from OAM4558g, a randomized phase II study evaluating MetMAb or placebo in combination with erlotinib in advanced NSCLC. J. Clin. Oncol. Abstr. 29, 7505 (2011).
    • (2011) J. Clin. Oncol. Abstr. , vol.29 , pp. 7505
    • Spigel, D.R.1
  • 168
    • 84856136679 scopus 로고    scopus 로고
    • Safety and efficacy of epirubicin cisplatin and capecitabine (ECX) plus rilotumumab (R) as first-line treatment for unresectable locally advanced (LA) or metastatic (M) gastric or esophagogastric junction (EGJ) adenocarcinoma
    • Stockholm
    • Iveson, T. et al. Safety and efficacy of epirubicin, cisplatin, and capecitabine (ECX) plus rilotumumab (R) as first-line treatment for unresectable locally advanced (LA) or metastatic (M) gastric or esophagogastric junction (EGJ) adenocarcinoma. Proc. Eur. Multidisc. Cancer Congr. Abstr. 6.504 (Stockholm, 2011).
    • (2011) Proc. Eur. Multidisc. Cancer Congr. Abstr. 6.504
    • Iveson, T.1
  • 169
    • 84856142307 scopus 로고    scopus 로고
    • Final results from Arq 197-209: A global randomized placebo-controlled phase 2 clinical trial of erlotinib plus ARQ 197 versus erlotinib plus placebo in previously treated EGFR-inhibitor Nave patients with advanced non-small cell lung cancer (NSCLC)
    • Von Pawel J. et al. Final results from Arq 197-209: a global randomized placebo-controlled phase 2 clinical trial of erlotinib plus ARQ 197 versus erlotinib plus placebo in previously treated EGFR-inhibitor Nave patients with advanced non-small cell lung cancer (NSCLC). J. Thoracic Oncol. Abstr. 5, 1 (2010).
    • (2010) J. Thoracic Oncol. Abstr. , vol.5 , pp. 1
    • Von Pawel, J.1
  • 170
    • 77953196233 scopus 로고    scopus 로고
    • ARQ-197, an oral small-molecule inhibitor of c-Met for the treatment of solid tumors
    • Bagai, R., Fan, W. & Ma, P. C. ARQ-197, an oral small-molecule inhibitor of c-Met for the treatment of solid tumors. IDrugs 13, 404-414 (2010).
    • (2010) IDrugs , vol.13 , pp. 404-414
    • Bagai, R.1    Fan, W.2    Ma, P.C.3
  • 171
    • 83255175512 scopus 로고    scopus 로고
    • Activity of cabozantinib (XL184) in soft tissue and bone: Results of a phase II randomized discontinuation trial (RDT) in patients (pts) with advanced solid tumors
    • Gordon MS. et al. Activity of cabozantinib (XL184) in soft tissue and bone: results of a phase II randomized discontinuation trial (RDT) in patients (pts) with advanced solid tumors. J. Clin. Oncol. Abstr. 29, 3010 (2011).
    • (2011) J. Clin. Oncol. Abstr. , vol.29 , pp. 3010
    • Gordon, M.S.1
  • 172
    • 83255192931 scopus 로고    scopus 로고
    • Activity of cabozantinib (XL184) in advanced ovarian cancer patients (pts): Results from a phase II randomized discontinuation trial (RDT)
    • Buckanovich RJ. et al. Activity of cabozantinib (XL184) in advanced ovarian cancer patients (pts): results from a phase II randomized discontinuation trial (RDT). J. Clin. Oncol. Abstr. 29, 5008 (2011).
    • (2011) J. Clin. Oncol. Abstr. , vol.29 , pp. 5008
    • Buckanovich, R.J.1
  • 173
    • 80053571555 scopus 로고    scopus 로고
    • Cabozantinib (XL184) in metastatic castration-resistant prostate cancer (mCRPC): Results from a phase II randomized discontinuation trial
    • Hussain M. et al. Cabozantinib (XL184) in metastatic castration-resistant prostate cancer (mCRPC): results from a phase II randomized discontinuation trial. J. Clin. Oncol. 29, 4516 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 4516
    • Hussain, M.1
  • 174
    • 79959936054 scopus 로고    scopus 로고
    • Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer
    • Kurzrock, R. et al. Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer. J. Clin. Oncol. 29, 2660-2666 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 2660-2666
    • Kurzrock, R.1
  • 175
    • 79955781270 scopus 로고    scopus 로고
    • Synergistic effects of foretinib with HER-targeted agents in MET and HER1-or HER2-coactivated tumor cells
    • Liu, L. et al. Synergistic effects of foretinib with HER-targeted agents in MET and HER1-or HER2-coactivated tumor cells. Mol. Cancer Ther. 10, 518-530 (2011).
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 518-530
    • Liu, L.1
  • 176
    • 75749146563 scopus 로고    scopus 로고
    • Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors
    • Zhang, J. et al. Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature 463, 501-506 (2010).
    • (2010) Nature , vol.463 , pp. 501-506
    • Zhang, J.1
  • 177
    • 0027337146 scopus 로고
    • Proteolytic processing of the hepatocytes growth factor/scatter factor receptor by furin
    • DOI 10.1016/0014-5793(93)80958-W
    • Komada, M. et al. Proteolytic processing of the hepatocyte growth factor/scatter factor receptor by furin. FEBS Lett. 328, 25-29 (1993). (Pubitemid 23234758)
    • (1993) FEBS Letters , vol.328 , Issue.1-2 , pp. 25-29
    • Komada, M.1    Hatsuzawa, K.2    Shibamoto, S.3    Ito, F.4    Nakayama, K.5    Kitamura, N.6
  • 181
    • 0025119463 scopus 로고
    • Scatter factor: Molecular characteristics and effect on the invasiveness of epithelial cells
    • Weidner, K. M., Behrens, J., Vandekerckhove, J. & Birchmeier, W. Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells. J. Cell Biol. 111, 2097-2108 (1990).
    • (1990) J. Cell Biol. , vol.111 , pp. 2097-2108
    • Weidner, K.M.1    Behrens, J.2    Vandekerckhove, J.3    Birchmeier, W.4
  • 182
    • 0026655776 scopus 로고
    • Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor
    • Rong, S. et al. Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor. Mol. Cell. Biol. 12, 5152-5158 (1992).
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5152-5158
    • Rong, S.1
  • 183
    • 0029910845 scopus 로고    scopus 로고
    • Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers
    • Sakata, H. et al. Hepatocyte growth factor/scatter factor overexpression induces growth, abnormal development, and tumor formation in transgenic mouse livers. Cell Growth Differ. 7, 1513-1523 (1996). (Pubitemid 26378346)
    • (1996) Cell Growth and Differentiation , vol.7 , Issue.11 , pp. 1513-1523
    • Sakata, H.1    Takayama, H.2    Sharp, R.3    Rubin, J.S.4    Merlino, G.5    LaRochelle, W.J.6
  • 184
    • 0033624921 scopus 로고    scopus 로고
    • Role of Gab l in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen- activated protein kinase activation
    • DOI 10.1128/MCB.20.10.3695-3704.2000
    • Itoh, M. et al. Role of Gab1 in heart, placenta, and skin development and growth factor-and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation. Mol. Cell. Biol. 20, 3695-3704 (2000). (Pubitemid 30243915)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.10 , pp. 3695-3704
    • Itoh, M.1    Yoshida, Y.2    Nishida, K.3    Narimatsu, M.4    Hibi, M.5    Hirano, T.6
  • 185
    • 0034683667 scopus 로고    scopus 로고
    • Essential role of Gab1 for signaling by the c-Met receptor in vivo
    • Sachs, M. et al. Essential role of Gab1 for signaling by the c-Met receptor in vivo. J. Cell Biol. 150, 1375-1384 (2000).
    • (2000) J. Cell Biol. , vol.150 , pp. 1375-1384
    • Sachs, M.1
  • 186
    • 0034721647 scopus 로고    scopus 로고
    • InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase
    • Shen, Y., Naujokas, M., Park, M. & Ireton, K. InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase. Cell 103, 501-510 (2000).
    • (2000) Cell , vol.103 , pp. 501-510
    • Shen, Y.1    Naujokas, M.2    Park, M.3    Ireton, K.4
  • 187
    • 58149352266 scopus 로고    scopus 로고
    • MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis
    • Stein, U. et al. MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Nature Med. 15, 59-67 (2009).
    • (2009) Nature Med. , vol.15 , pp. 59-67
    • Stein, U.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.