-
1
-
-
84861185907
-
Molecular networks that regulate cancer metastasis
-
Spano D, Heck C, De Antonellis P, et al. Molecular networks that regulate cancer metastasis. Semin Cancer Biol 2012; 22: 234-49.
-
(2012)
Semin Cancer Biol
, vol.22
, pp. 234-249
-
-
Spano, D.1
Heck, C.2
De Antonellis, P.3
-
2
-
-
33746851956
-
Tumor metastasis: Mechanistic insights and clinical challenges
-
Steeg PS,. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 2006; 12: 895-904.
-
(2006)
Nat Med
, vol.12
, pp. 895-904
-
-
Steeg, P.S.1
-
3
-
-
33751252276
-
Cancer metastasis: Building a framework
-
Gupta GP, Massague J,. Cancer metastasis: building a framework. Cell 2006; 127: 679-95.
-
(2006)
Cell
, vol.127
, pp. 679-695
-
-
Gupta, G.P.1
Massague, J.2
-
4
-
-
2442676752
-
Physiological and pathological responses to hypoxia
-
Michiels C,. Physiological and pathological responses to hypoxia. Am J Pathol 2004; 164: 1875-82.
-
(2004)
Am J Pathol
, vol.164
, pp. 1875-1882
-
-
Michiels, C.1
-
5
-
-
84856739946
-
Hypoxia-inducible factors in physiology and medicine
-
Semenza GL,. Hypoxia-inducible factors in physiology and medicine. Cell 2012; 148: 399-408.
-
(2012)
Cell
, vol.148
, pp. 399-408
-
-
Semenza, G.L.1
-
6
-
-
0032190614
-
Hypoxia-inducible factor 1: Master regulator of O2 homeostasis
-
Semenza GL,. Hypoxia-inducible factor 1: master regulator of O2 homeostasis. Curr Opin Genet Dev 1998; 8: 588-94.
-
(1998)
Curr Opin Genet Dev
, vol.8
, pp. 588-594
-
-
Semenza, G.L.1
-
7
-
-
33744954065
-
Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: The role of HIF-1alpha, HIF-2alpha, and other pathways
-
Elvidge GP, Glenny L, Appelhoff RJ, et al. Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. J Biol Chem 2006; 281: 15215-26.
-
(2006)
J Biol Chem
, vol.281
, pp. 15215-15226
-
-
Elvidge, G.P.1
Glenny, L.2
Appelhoff, R.J.3
-
8
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
-
Wang GL, Jiang BH, Rue EA, et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995; 92: 5510-14.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5510-5514
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
-
9
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 1999; 59: 5830-5.
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
-
10
-
-
73049091140
-
Natural compounds and the hypoxia-inducible factor (HIF) signalling pathway
-
Manolescu B, Oprea E, Busu C, et al. Natural compounds and the hypoxia-inducible factor (HIF) signalling pathway. Biochimie 2009; 91: 1347-58.
-
(2009)
Biochimie
, vol.91
, pp. 1347-1358
-
-
Manolescu, B.1
Oprea, E.2
Busu, C.3
-
11
-
-
40949132841
-
Turn me on: Regulating HIF transcriptional activity
-
Lisy K, Peet DJ,. Turn me on: regulating HIF transcriptional activity. Cell Death Differ 2008; 15: 642-9.
-
(2008)
Cell Death Differ
, vol.15
, pp. 642-649
-
-
Lisy, K.1
Peet, D.J.2
-
12
-
-
33747660292
-
Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system
-
Stiehl DP, Wirthner R, Koditz J, et al. Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system. J Biol Chem 2006; 281: 23482-91.
-
(2006)
J Biol Chem
, vol.281
, pp. 23482-23491
-
-
Stiehl, D.P.1
Wirthner, R.2
Koditz, J.3
-
13
-
-
1642315195
-
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
-
Koivunen P, Hirsila M, Gunzler V, et al. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. J Biol Chem 2004; 279: 9899-904.
-
(2004)
J Biol Chem
, vol.279
, pp. 9899-9904
-
-
Koivunen, P.1
Hirsila, M.2
Gunzler, V.3
-
16
-
-
84861206557
-
Selective recruitment of an E2∼ubiquitin complex by an E3 ubiquitin ligase
-
Spratt DE, Wu K, Kovacev J, et al. Selective recruitment of an E2∼ubiquitin complex by an E3 ubiquitin ligase. J Biol Chem 2012; 287: 17374-85.
-
(2012)
J Biol Chem
, vol.287
, pp. 17374-17385
-
-
Spratt, D.E.1
Wu, K.2
Kovacev, J.3
-
17
-
-
0034641615
-
Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
-
Kamura T, Sato S, Iwai K, et al. Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc Natl Acad Sci USA 2000; 97: 10430-5.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10430-10435
-
-
Kamura, T.1
Sato, S.2
Iwai, K.3
-
18
-
-
0036083396
-
The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction
-
Glickman MH, Ciechanover A,. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev 2002; 82: 373-428.
-
(2002)
Physiol Rev
, vol.82
, pp. 373-428
-
-
Glickman, M.H.1
Ciechanover, A.2
-
19
-
-
46149124082
-
Monoclonal antibody-based screening assay for factor inhibiting hypoxia-inducible factor inhibitors
-
Lee SH, Jeong Hee M, Eun Ah C, et al. Monoclonal antibody-based screening assay for factor inhibiting hypoxia-inducible factor inhibitors. J Biomol Screen 2008; 13: 494-503.
-
(2008)
J Biomol Screen
, vol.13
, pp. 494-503
-
-
Lee, S.H.1
Jeong Hee, M.2
Eun Ah, C.3
-
20
-
-
0037117479
-
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha
-
Freedman SJ, Sun ZY, Poy F, et al. Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proc Natl Acad Sci USA 2002; 99: 5367-72.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 5367-5372
-
-
Freedman, S.J.1
Sun, Z.Y.2
Poy, F.3
-
21
-
-
0029944965
-
Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
-
Jiang BH, Rue E, Wang GL, et al. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem 1996; 271: 17771-8.
-
(1996)
J Biol Chem
, vol.271
, pp. 17771-17778
-
-
Jiang, B.H.1
Rue, E.2
Wang, G.L.3
-
22
-
-
0030460724
-
Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
-
Semenza GL, Jiang BH, Leung SW, et al. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 1996; 271: 32529-37.
-
(1996)
J Biol Chem
, vol.271
, pp. 32529-32537
-
-
Semenza, G.L.1
Jiang, B.H.2
Leung, S.W.3
-
23
-
-
2942731503
-
Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia
-
Nakayama K, Frew IJ, Hagensen M, et al. Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia. Cell 2004; 117: 941-52.
-
(2004)
Cell
, vol.117
, pp. 941-952
-
-
Nakayama, K.1
Frew, I.J.2
Hagensen, M.3
-
24
-
-
0034925041
-
Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1
-
Jiang BH, Jiang G, Zheng JZ, et al. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ 2001; 12: 363-9.
-
(2001)
Cell Growth Differ
, vol.12
, pp. 363-369
-
-
Jiang, B.H.1
Jiang, G.2
Zheng, J.Z.3
-
25
-
-
33749817738
-
Hypoxia-inducible factor-1alpha expression requires PI 3-kinase activity and correlates with Akt1 phosphorylation in invasive breast carcinomas
-
Gort EH, Groot AJ, Derks, van de Ven TL, et al. Hypoxia-inducible factor-1alpha expression requires PI 3-kinase activity and correlates with Akt1 phosphorylation in invasive breast carcinomas. Oncogene 2006; 25: 6123-7.
-
(2006)
Oncogene
, vol.25
, pp. 6123-6127
-
-
Gort, E.H.1
Groot, A.J.2
Derks3
Van De Ven, T.L.4
-
26
-
-
0032725554
-
P42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
-
Richard DE, Berra E, Gothie E, et al. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1. J Biol Chem 1999; 274: 32631-7.
-
(1999)
J Biol Chem
, vol.274
, pp. 32631-32637
-
-
Richard, D.E.1
Berra, E.2
Gothie, E.3
-
27
-
-
73349119966
-
MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells
-
Salmond RJ, Emery J, Okkenhaug K, et al. MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells. J Immunol 2009; 183: 7388-97.
-
(2009)
J Immunol
, vol.183
, pp. 7388-7397
-
-
Salmond, R.J.1
Emery, J.2
Okkenhaug, K.3
-
28
-
-
0026576375
-
SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors
-
McGlade CJ, Ellis C, Reedijk M, et al. SH2 domains of the p85 alpha subunit of phosphatidylinositol 3-kinase regulate binding to growth factor receptors. Mol Cell Biol 1992; 12: 991-7.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 991-997
-
-
McGlade, C.J.1
Ellis, C.2
Reedijk, M.3
-
29
-
-
0035012605
-
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
Laughner E, Taghavi P, Chiles K, et al. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 2001; 21: 3995-4004.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3995-4004
-
-
Laughner, E.1
Taghavi, P.2
Chiles, K.3
-
30
-
-
0037008770
-
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
-
Treins C, Giorgetti-Peraldi S, Murdaca J, et al. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. J Biol Chem 2002; 277: 27975-81.
-
(2002)
J Biol Chem
, vol.277
, pp. 27975-27981
-
-
Treins, C.1
Giorgetti-Peraldi, S.2
Murdaca, J.3
-
31
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong H, Chiles K, Feldser D, et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000; 60: 1541-5.
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
-
32
-
-
79959845729
-
Overexpression of MMP-9 and HIF-1alpha in breast cancer cells under hypoxic conditions
-
Choi JY, Jang YS, Min SY, et al. Overexpression of MMP-9 and HIF-1alpha in breast cancer cells under hypoxic conditions. J Breast Cancer 2011; 14: 88-95.
-
(2011)
J Breast Cancer
, vol.14
, pp. 88-95
-
-
Choi, J.Y.1
Jang, Y.S.2
Min, S.Y.3
-
33
-
-
34248193424
-
Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma
-
Kumar SM, Yu H, Edwards R, et al. Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma. Cancer Res 2007; 67: 3177-84.
-
(2007)
Cancer Res
, vol.67
, pp. 3177-3184
-
-
Kumar, S.M.1
Yu, H.2
Edwards, R.3
-
34
-
-
84876081696
-
Targeting PI3K/Akt represses hypoxia inducible factor-1alpha activation and sensitizes rhabdomyosarcoma and Ewing's sarcoma cells for apoptosis
-
Kilic-Eren M, Boylu T, Tabor V,. Targeting PI3K/Akt represses hypoxia inducible factor-1alpha activation and sensitizes rhabdomyosarcoma and Ewing's sarcoma cells for apoptosis. Cancer Cell Int 2013; 13: 36.
-
(2013)
Cancer Cell Int
, vol.13
, pp. 36
-
-
Kilic-Eren, M.1
Boylu, T.2
Tabor, V.3
-
35
-
-
0034050050
-
Loss of PTEN facilitates HIF-1-mediated gene expression
-
Zundel W, Schindler C, Haas-Kogan D, et al. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev 2000; 14: 391-6.
-
(2000)
Genes Dev
, vol.14
, pp. 391-396
-
-
Zundel, W.1
Schindler, C.2
Haas-Kogan, D.3
-
36
-
-
0141705466
-
Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin
-
El-Hashemite N, Walker V, Zhang H, et al. Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin. Cancer Res 2003; 63: 5173-7.
-
(2003)
Cancer Res
, vol.63
, pp. 5173-5177
-
-
El-Hashemite, N.1
Walker, V.2
Zhang, H.3
-
37
-
-
0037515549
-
MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300
-
Sang N, Stiehl DP, Bohensky J, et al. MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300. J Biol Chem 2003; 278: 14013-19.
-
(2003)
J Biol Chem
, vol.278
, pp. 14013-14019
-
-
Sang, N.1
Stiehl, D.P.2
Bohensky, J.3
-
38
-
-
9144250328
-
Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity
-
Lancaster DE, McNeill LA, McDonough MA, et al. Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity. Biochem J 2004; 383 (Part 3): 429-37.
-
(2004)
Biochem J
, vol.383
, pp. 429-437
-
-
Lancaster, D.E.1
McNeill, L.A.2
McDonough, M.A.3
-
39
-
-
34447249876
-
SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity
-
Berta MA, Mazure N, Hattab M, et al. SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity. Biochem Biophys Res Commun 2007; 360: 646-52.
-
(2007)
Biochem Biophys Res Commun
, vol.360
, pp. 646-652
-
-
Berta, M.A.1
Mazure, N.2
Hattab, M.3
-
40
-
-
0042564792
-
S-nitrosation of Cys-800 of HIF-1alpha protein activates its interaction with p300 and stimulates its transcriptional activity
-
Yasinska IM, Sumbayev VV,. S-nitrosation of Cys-800 of HIF-1alpha protein activates its interaction with p300 and stimulates its transcriptional activity. FEBS Lett 2003; 549: 105-9.
-
(2003)
FEBS Lett
, vol.549
, pp. 105-109
-
-
Yasinska, I.M.1
Sumbayev, V.V.2
-
41
-
-
33745006163
-
Nitric oxide inhibits HIF-1alpha protein accumulation under hypoxic conditions: Implication of 2-oxoglutarate and iron
-
Kozhukhar AV, Yasinska IM, Sumbayev VV,. Nitric oxide inhibits HIF-1alpha protein accumulation under hypoxic conditions: implication of 2-oxoglutarate and iron. Biochimie 2006; 88: 411-18.
-
(2006)
Biochimie
, vol.88
, pp. 411-418
-
-
Kozhukhar, A.V.1
Yasinska, I.M.2
Sumbayev, V.V.3
-
42
-
-
33744782345
-
Peroxynitrite as an alternative donor of oxygen in HIF-1alpha proline hydroxylation under low oxygen availability
-
Sumbayev VV, Yasinska IM,. Peroxynitrite as an alternative donor of oxygen in HIF-1alpha proline hydroxylation under low oxygen availability. Free Radic Res 2006; 40: 631-5.
-
(2006)
Free Radic Res
, vol.40
, pp. 631-635
-
-
Sumbayev, V.V.1
Yasinska, I.M.2
-
43
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
-
Isaacs JS, Jung YJ, Mimnaugh EG, et al. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. J Biol Chem 2002; 277: 29936-44.
-
(2002)
J Biol Chem
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mimnaugh, E.G.3
-
44
-
-
34047215555
-
RACK1 vs. HSP90: Competition for HIF-1 alpha degradation vs. Stabilization
-
Liu YV, Semenza GL,. RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization. Cell Cycle 2007; 6: 656-9.
-
(2007)
Cell Cycle
, vol.6
, pp. 656-659
-
-
Liu, Y.V.1
Semenza, G.L.2
-
45
-
-
0037031808
-
Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus
-
Makino Y, Kanopka A, Wilson WJ, et al. Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus. J Biol Chem 2002; 277: 32405-8.
-
(2002)
J Biol Chem
, vol.277
, pp. 32405-32408
-
-
Makino, Y.1
Kanopka, A.2
Wilson, W.J.3
-
46
-
-
0035969508
-
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
-
Makino Y, Cao R, Svensson K, et al. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature 2001; 414: 550-4.
-
(2001)
Nature
, vol.414
, pp. 550-554
-
-
Makino, Y.1
Cao, R.2
Svensson, K.3
-
47
-
-
0031733828
-
Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha
-
Gu YZ, Moran SM, Hogenesch JB, et al. Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. Gene Expr 1998; 7: 205-13.
-
(1998)
Gene Expr
, vol.7
, pp. 205-213
-
-
Gu, Y.Z.1
Moran, S.M.2
Hogenesch, J.B.3
-
48
-
-
0033585416
-
AHIF: The missing link between HIF-1 and VHL?
-
Neckers LM,. aHIF: the missing link between HIF-1 and VHL? J Natl Cancer Inst 1999; 91: 106-7.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 106-107
-
-
Neckers, L.M.1
-
49
-
-
0032900610
-
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
-
Bhattacharya S, Michels CL, Leung MK, et al. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev 1999; 13: 64-75.
-
(1999)
Genes Dev
, vol.13
, pp. 64-75
-
-
Bhattacharya, S.1
Michels, C.L.2
Leung, M.K.3
-
50
-
-
0036674501
-
Dissemination and growth of cancer cells in metastatic sites
-
Chambers AF, Groom AC, MacDonald IC,. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002; 2: 563-72.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 563-572
-
-
Chambers, A.F.1
Groom, A.C.2
Macdonald, I.C.3
-
51
-
-
80054686286
-
Tumor metastasis: Molecular insights and evolving paradigms
-
Valastyan S, Weinberg RA,. Tumor metastasis: molecular insights and evolving paradigms. Cell 2011; 147: 275-92.
-
(2011)
Cell
, vol.147
, pp. 275-292
-
-
Valastyan, S.1
Weinberg, R.A.2
-
52
-
-
0031969264
-
Angiogenesis and tumor metastasis
-
Zetter BR,. Angiogenesis and tumor metastasis. Annu Rev Med 1998; 49: 407-24.
-
(1998)
Annu Rev Med
, vol.49
, pp. 407-424
-
-
Zetter, B.R.1
-
53
-
-
33749478922
-
Cancer's molecular sweet tooth and the Warburg effect
-
Kim JW, Dang CV,. Cancer's molecular sweet tooth and the Warburg effect. Cancer Res 2006; 66: 8927-30.
-
(2006)
Cancer Res
, vol.66
, pp. 8927-8930
-
-
Kim, J.W.1
Dang, C.V.2
-
54
-
-
47749116480
-
Finding an "achilles' heel" of cancer: The role of glucose and glutamine metabolism in the survival of transformed cells
-
Yuneva M,. Finding an "Achilles' heel" of cancer: the role of glucose and glutamine metabolism in the survival of transformed cells. Cell Cycle 2008; 7: 2083-9.
-
(2008)
Cell Cycle
, vol.7
, pp. 2083-2089
-
-
Yuneva, M.1
-
55
-
-
79957894276
-
Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
-
Carmeliet P, Jain RK,. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov 2011; 10: 417-27.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 417-427
-
-
Carmeliet, P.1
Jain, R.K.2
-
56
-
-
0141956303
-
Overexpression of hypoxia-inducible-factor 1alpha(HIF-1alpha) in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage
-
Kurokawa T, Miyamoto M, Kato K, et al. Overexpression of hypoxia-inducible-factor 1alpha(HIF-1alpha) in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage. Br J Cancer 2003; 89: 1042-7.
-
(2003)
Br J Cancer
, vol.89
, pp. 1042-1047
-
-
Kurokawa, T.1
Miyamoto, M.2
Kato, K.3
-
57
-
-
0029761644
-
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
-
Forsythe JA, Jiang BH, Iyer NV, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996; 16: 4604-13.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4604-4613
-
-
Forsythe, J.A.1
Jiang, B.H.2
Iyer, N.V.3
-
58
-
-
0344874751
-
Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1
-
Kelly BD, Hackett SF, Hirota K, et al. Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1. Circ Res 2003; 93: 1074-81.
-
(2003)
Circ Res
, vol.93
, pp. 1074-1081
-
-
Kelly, B.D.1
Hackett, S.F.2
Hirota, K.3
-
59
-
-
54049146968
-
The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1
-
Simon MP, Tournaire R, Pouyssegur J,. The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1. J Cell Physiol 2008; 217: 809-18.
-
(2008)
J Cell Physiol
, vol.217
, pp. 809-818
-
-
Simon, M.P.1
Tournaire, R.2
Pouyssegur, J.3
-
60
-
-
4043184065
-
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
-
Ceradini DJ, Kulkarni AR, Callaghan MJ, et al. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med 2004; 10: 858-64.
-
(2004)
Nat Med
, vol.10
, pp. 858-864
-
-
Ceradini, D.J.1
Kulkarni, A.R.2
Callaghan, M.J.3
-
61
-
-
37349115260
-
Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia
-
Bosch-Marce M, Okuyama H, Wesley JB, et al. Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circ Res 2007; 101: 1310-18.
-
(2007)
Circ Res
, vol.101
, pp. 1310-1318
-
-
Bosch-Marce, M.1
Okuyama, H.2
Wesley, J.B.3
-
62
-
-
0242581718
-
Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells
-
Gunaratnam L, Morley M, Franovic A, et al. Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells. J Biol Chem 2003; 278: 44966-74.
-
(2003)
J Biol Chem
, vol.278
, pp. 44966-44974
-
-
Gunaratnam, L.1
Morley, M.2
Franovic, A.3
-
63
-
-
0032557564
-
Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells
-
Gerber HP, Dixit V, Ferrara N,. Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J Biol Chem 1998; 273: 13313-16.
-
(1998)
J Biol Chem
, vol.273
, pp. 13313-13316
-
-
Gerber, H.P.1
Dixit, V.2
Ferrara, N.3
-
64
-
-
0035347301
-
Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival
-
Reinmuth N, Liu W, Jung YD, et al. Induction of VEGF in perivascular cells defines a potential paracrine mechanism for endothelial cell survival. FASEB J 2001; 15: 1239-41.
-
(2001)
FASEB J
, vol.15
, pp. 1239-1241
-
-
Reinmuth, N.1
Liu, W.2
Jung, Y.D.3
-
65
-
-
15144358851
-
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis
-
Maisonpierre PC, Suri C, Jones PF, et al. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 1997; 277: 55-60.
-
(1997)
Science
, vol.277
, pp. 55-60
-
-
Maisonpierre, P.C.1
Suri, C.2
Jones, P.F.3
-
66
-
-
0033565540
-
VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells
-
Asahara T, Takahashi T, Masuda H, et al. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells. EMBO J 1999; 18: 3964-72.
-
(1999)
EMBO J
, vol.18
, pp. 3964-3972
-
-
Asahara, T.1
Takahashi, T.2
Masuda, H.3
-
67
-
-
59649107771
-
Role of stem cell factor and bone marrow-derived fibroblasts in airway remodeling
-
Dolgachev VA, Ullenbruch MR, Lukacs NW, et al. Role of stem cell factor and bone marrow-derived fibroblasts in airway remodeling. Am J Pathol 2009; 174: 390-400.
-
(2009)
Am J Pathol
, vol.174
, pp. 390-400
-
-
Dolgachev, V.A.1
Ullenbruch, M.R.2
Lukacs, N.W.3
-
68
-
-
79958696667
-
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kgamma, a single convergent point promoting tumor inflammation and progression
-
Schmid MC, Avraamides CJ, Dippold HC, et al. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kgamma, a single convergent point promoting tumor inflammation and progression. Cancer Cell 2011; 19: 715-27.
-
(2011)
Cancer Cell
, vol.19
, pp. 715-727
-
-
Schmid, M.C.1
Avraamides, C.J.2
Dippold, H.C.3
-
69
-
-
75849154010
-
Cancer associated fibroblasts in cancer pathogenesis
-
Franco OE, Shaw AK, Strand DW, et al. Cancer associated fibroblasts in cancer pathogenesis. Semin Cell Dev Biol 2010; 21: 33-9.
-
(2010)
Semin Cell Dev Biol
, vol.21
, pp. 33-39
-
-
Franco, O.E.1
Shaw, A.K.2
Strand, D.W.3
-
71
-
-
84873721240
-
HIF-1alpha contributes to hypoxia-induced invasion and metastasis of esophageal carcinoma via inhibiting E-cadherin and promoting MMP-2 expression
-
Jing SW, Wang YD, Kuroda M, et al. HIF-1alpha contributes to hypoxia-induced invasion and metastasis of esophageal carcinoma via inhibiting E-cadherin and promoting MMP-2 expression. Acta Med Okayama 2012; 66: 399-407.
-
(2012)
Acta Med Okayama
, vol.66
, pp. 399-407
-
-
Jing, S.W.1
Wang, Y.D.2
Kuroda, M.3
-
72
-
-
13944252559
-
Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma
-
Petrella BL, Lohi J, Brinckerhoff CE,. Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. Oncogene 2005; 24: 1043-52.
-
(2005)
Oncogene
, vol.24
, pp. 1043-1052
-
-
Petrella, B.L.1
Lohi, J.2
Brinckerhoff, C.E.3
-
73
-
-
0027982162
-
Integrins as dynamic regulators of vascular function
-
Luscinskas FW, Lawler J,. Integrins as dynamic regulators of vascular function. FASEB J 1994; 8: 929-38.
-
(1994)
FASEB J
, vol.8
, pp. 929-938
-
-
Luscinskas, F.W.1
Lawler, J.2
-
74
-
-
0035900767
-
Glucose catabolism in cancer cells: Identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions
-
Mathupala SP, Rempel A, Pedersen PL,. Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions. J Biol Chem 2001; 276: 43407-12.
-
(2001)
J Biol Chem
, vol.276
, pp. 43407-43412
-
-
Mathupala, S.P.1
Rempel, A.2
Pedersen, P.L.3
-
75
-
-
0037155247
-
Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect
-
Minchenko A, Leshchinsky I, Opentanova I, et al. Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect. J Biol Chem 2002; 277: 6183-7.
-
(2002)
J Biol Chem
, vol.277
, pp. 6183-6187
-
-
Minchenko, A.1
Leshchinsky, I.2
Opentanova, I.3
-
76
-
-
0242710750
-
Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo
-
Minchenko O, Opentanova I, Caro J,. Hypoxic regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene family (PFKFB-1-4) expression in vivo. FEBS Lett 2003; 554: 264-70.
-
(2003)
FEBS Lett
, vol.554
, pp. 264-270
-
-
Minchenko, O.1
Opentanova, I.2
Caro, J.3
-
77
-
-
33751086440
-
Hypoxia results in an HIF-1-dependent induction of brain-specific aldolase C in lung epithelial cells
-
Jean JC, Rich CB, Joyce-Brady M,. Hypoxia results in an HIF-1-dependent induction of brain-specific aldolase C in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2006; 291: L950-L956.
-
(2006)
Am J Physiol Lung Cell Mol Physiol
, vol.291
, pp. L950-L956
-
-
Jean, J.C.1
Rich, C.B.2
Joyce-Brady, M.3
-
78
-
-
2442430224
-
Hypoxia up-regulates triosephosphate isomerase expression via a HIF-dependent pathway
-
Gess B, Hofbauer KH, Deutzmann R, et al. Hypoxia up-regulates triosephosphate isomerase expression via a HIF-dependent pathway. Pflugers Arch 2004; 448: 175-80.
-
(2004)
Pflugers Arch
, vol.448
, pp. 175-180
-
-
Gess, B.1
Hofbauer, K.H.2
Deutzmann, R.3
-
79
-
-
0037133736
-
Identification of an additional hypoxia responsive element in the glyceraldehyde-3-phosphate dehydrogenase gene promoter
-
Lu S, Gu X, Hoestje S, et al. Identification of an additional hypoxia responsive element in the glyceraldehyde-3-phosphate dehydrogenase gene promoter. Biochim Biophys Acta 2002; 1574: 152-6.
-
(2002)
Biochim Biophys Acta
, vol.1574
, pp. 152-156
-
-
Lu, S.1
Gu, X.2
Hoestje, S.3
-
80
-
-
0028359320
-
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3′ enhancer
-
Firth JD, Ebert BL, Pugh CW, et al. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3′ enhancer. Proc Natl Acad Sci USA 1994; 91: 6496-500.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 6496-6500
-
-
Firth, J.D.1
Ebert, B.L.2
Pugh, C.W.3
-
81
-
-
0028068606
-
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
-
Semenza GL, Roth PH, Fang HM, et al. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 1994; 269: 23757-63.
-
(1994)
J Biol Chem
, vol.269
, pp. 23757-23763
-
-
Semenza, G.L.1
Roth, P.H.2
Fang, H.M.3
-
82
-
-
0028805375
-
Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences
-
Ebert BL, Firth JD, Ratcliffe PJ,. Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences. J Biol Chem 1995; 270: 29083-9.
-
(1995)
J Biol Chem
, vol.270
, pp. 29083-29089
-
-
Ebert, B.L.1
Firth, J.D.2
Ratcliffe, P.J.3
-
83
-
-
34547133742
-
Hypoxic upregulation of glucose transporters in BeWo choriocarcinoma cells is mediated by hypoxia-inducible factor-1
-
Baumann MU, Zamudio S, Illsley NP,. Hypoxic upregulation of glucose transporters in BeWo choriocarcinoma cells is mediated by hypoxia-inducible factor-1. Am J Physiol Cell Physiol 2007; 293: C477-C485.
-
(2007)
Am J Physiol Cell Physiol
, vol.293
, pp. C477-C485
-
-
Baumann, M.U.1
Zamudio, S.2
Illsley, N.P.3
-
84
-
-
0038049137
-
Tumour-cell invasion and migration: Diversity and escape mechanisms
-
Friedl P, Wolf K,. Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer 2003; 3: 362-74.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 362-374
-
-
Friedl, P.1
Wolf, K.2
-
85
-
-
70450198396
-
Epithelial-mesenchymal transitions in development and disease
-
Thiery JP, Acloque H, Huang RY, et al. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139: 871-90.
-
(2009)
Cell
, vol.139
, pp. 871-890
-
-
Thiery, J.P.1
Acloque, H.2
Huang, R.Y.3
-
86
-
-
0035964349
-
Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
-
Brabletz T, Jung A, Reu S, et al. Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci USA 2001; 98: 10356-61.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10356-10361
-
-
Brabletz, T.1
Jung, A.2
Reu, S.3
-
87
-
-
27744527762
-
Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma
-
Giannelli G, Bergamini C, Fransvea E, et al. Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma. Gastroenterology 2005; 129: 1375-83.
-
(2005)
Gastroenterology
, vol.129
, pp. 1375-1383
-
-
Giannelli, G.1
Bergamini, C.2
Fransvea, E.3
-
88
-
-
77956910480
-
HnRNP A2/B1 modulates epithelial-mesenchymal transition in lung cancer cell lines
-
Tauler J, Zudaire E, Liu H, et al. hnRNP A2/B1 modulates epithelial-mesenchymal transition in lung cancer cell lines. Cancer Res 2010; 70: 7137-47.
-
(2010)
Cancer Res
, vol.70
, pp. 7137-7147
-
-
Tauler, J.1
Zudaire, E.2
Liu, H.3
-
89
-
-
77956280130
-
Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness
-
Giannoni E, Bianchini F, Masieri L, et al. Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness. Cancer Res 2010; 70: 6945-56.
-
(2010)
Cancer Res
, vol.70
, pp. 6945-6956
-
-
Giannoni, E.1
Bianchini, F.2
Masieri, L.3
-
90
-
-
84866875005
-
Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential
-
Salnikov AV, Liu L, Platen M, et al. Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential. PLoS One 2012; 7: e46391.
-
(2012)
PLoS One
, vol.7
, pp. e46391
-
-
Salnikov, A.V.1
Liu, L.2
Platen, M.3
-
91
-
-
33645090169
-
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B
-
Krishnamachary B, Zagzag D, Nagasawa H, et al. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res 2006; 66: 2725-31.
-
(2006)
Cancer Res
, vol.66
, pp. 2725-2731
-
-
Krishnamachary, B.1
Zagzag, D.2
Nagasawa, H.3
-
92
-
-
33845724527
-
VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail
-
Evans AJ, Russell RC, Roche O, et al. VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and snail. Mol Cell Biol 2007; 27: 157-69.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 157-169
-
-
Evans, A.J.1
Russell, R.C.2
Roche, O.3
-
93
-
-
40249113328
-
Direct regulation of TWIST by HIF-1alpha promotes metastasis
-
Yang MH, Wu MZ, Chiou SH, et al. Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol 2008; 10: 295-305.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 295-305
-
-
Yang, M.H.1
Wu, M.Z.2
Chiou, S.H.3
-
94
-
-
84877101126
-
HIF1alpha and HIF2alpha independently activate SRC to promote melanoma metastases
-
Hanna SC, Krishnan B, Bailey ST, et al. HIF1alpha and HIF2alpha independently activate SRC to promote melanoma metastases. J Clin Invest 2013; 123: 2078-93.
-
(2013)
J Clin Invest
, vol.123
, pp. 2078-2093
-
-
Hanna, S.C.1
Krishnan, B.2
Bailey, S.T.3
-
95
-
-
79959541003
-
The 'ins' and 'outs' of podosomes and invadopodia: Characteristics, formation and function
-
Murphy DA, Courtneidge SA,. The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function. Nat Rev Mol Cell Biol 2011; 12: 413-26.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 413-426
-
-
Murphy, D.A.1
Courtneidge, S.A.2
-
96
-
-
79952499030
-
Twist1-induced invadopodia formation promotes tumor metastasis
-
Eckert MA, Lwin TM, Chang AT, et al. Twist1-induced invadopodia formation promotes tumor metastasis. Cancer Cell 2011; 19: 372-86.
-
(2011)
Cancer Cell
, vol.19
, pp. 372-386
-
-
Eckert, M.A.1
Lwin, T.M.2
Chang, A.T.3
-
97
-
-
84863335331
-
Targeted inhibition of Src kinase with dasatinib blocks thyroid cancer growth and metastasis
-
Chan CM, Jing X, Pike LA, et al. Targeted inhibition of Src kinase with dasatinib blocks thyroid cancer growth and metastasis. Clin Cancer Res 2012; 18: 3580-91.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 3580-3591
-
-
Chan, C.M.1
Jing, X.2
Pike, L.A.3
-
98
-
-
84860389759
-
HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs
-
Zhang H, Wong CC, Wei H, et al. HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs. Oncogene 2012; 31: 1757-70.
-
(2012)
Oncogene
, vol.31
, pp. 1757-1770
-
-
Zhang, H.1
Wong, C.C.2
Wei, H.3
-
99
-
-
84862801988
-
SDF-1alpha induces angiogenesis after traumatic brain injury
-
Li S, Wei M, Zhou Z, et al. SDF-1alpha induces angiogenesis after traumatic brain injury. Brain Res 2012; 1444: 76-86.
-
(2012)
Brain Res
, vol.1444
, pp. 76-86
-
-
Li, S.1
Wei, M.2
Zhou, Z.3
-
100
-
-
79251478398
-
Contribution of platelets to tumour metastasis
-
Gay LJ, Felding-Habermann B,. Contribution of platelets to tumour metastasis. Nat Rev Cancer 2011; 11: 123-34.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 123-134
-
-
Gay, L.J.1
Felding-Habermann, B.2
-
101
-
-
5044238876
-
Integrin signalling during tumour progression
-
Guo W, Giancotti FG,. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 2004; 5: 816-26.
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 816-826
-
-
Guo, W.1
Giancotti, F.G.2
-
102
-
-
57749105319
-
Hypoxia-inducible factor 1alpha mediates anoikis resistance via suppression of alpha5 integrin
-
Rohwer N, Welzel M, Daskalow K, et al. Hypoxia-inducible factor 1alpha mediates anoikis resistance via suppression of alpha5 integrin. Cancer Res 2008; 68: 10113-20.
-
(2008)
Cancer Res
, vol.68
, pp. 10113-10120
-
-
Rohwer, N.1
Welzel, M.2
Daskalow, K.3
-
103
-
-
69949101473
-
Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
-
Schafer ZT, Grassian AR, Song L, et al. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 2009; 461: 109-13.
-
(2009)
Nature
, vol.461
, pp. 109-113
-
-
Schafer, Z.T.1
Grassian, A.R.2
Song, L.3
-
104
-
-
84873414930
-
Extravasation of leukocytes in comparison to tumor cells
-
Strell C, Entschladen F,. Extravasation of leukocytes in comparison to tumor cells. Cell Commun Signal 2008; 6: 10.
-
(2008)
Cell Commun Signal
, vol.6
, pp. 10
-
-
Strell, C.1
Entschladen, F.2
-
105
-
-
84868257627
-
CD24 is an effector of HIF-1-driven primary tumor growth and metastasis
-
Thomas S, Harding MA, Smith SC, et al. CD24 is an effector of HIF-1-driven primary tumor growth and metastasis. Cancer Res 2012; 72: 5600-12.
-
(2012)
Cancer Res
, vol.72
, pp. 5600-5612
-
-
Thomas, S.1
Harding, M.A.2
Smith, S.C.3
-
106
-
-
0034544605
-
The CD24/P-selectin binding pathway initiates lung arrest of human A125 adenocarcinoma cells
-
Friederichs J, Zeller Y, Hafezi-Moghadam A, et al. The CD24/P-selectin binding pathway initiates lung arrest of human A125 adenocarcinoma cells. Cancer Res 2000; 60: 6714-22.
-
(2000)
Cancer Res
, vol.60
, pp. 6714-6722
-
-
Friederichs, J.1
Zeller, Y.2
Hafezi-Moghadam, A.3
-
107
-
-
79952176839
-
Direct measurements on CD24-mediated rolling of human breast cancer MCF-7 cells on E-selectin
-
Myung JH, Gajjar KA, Pearson RM, et al. Direct measurements on CD24-mediated rolling of human breast cancer MCF-7 cells on E-selectin. Anal Chem 2011; 83: 1078-83.
-
(2011)
Anal Chem
, vol.83
, pp. 1078-1083
-
-
Myung, J.H.1
Gajjar, K.A.2
Pearson, R.M.3
-
108
-
-
0141828145
-
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
-
Staller P, Sulitkova J, Lisztwan J, et al. Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003; 425: 307-11.
-
(2003)
Nature
, vol.425
, pp. 307-311
-
-
Staller, P.1
Sulitkova, J.2
Lisztwan, J.3
-
109
-
-
65349158225
-
Increased expression of SDF-1/CXCR4 is associated with lymph node metastasis of invasive micropapillary carcinoma of the breast
-
Liu F, Lang R, Wei J, et al. Increased expression of SDF-1/CXCR4 is associated with lymph node metastasis of invasive micropapillary carcinoma of the breast. Histopathology 2009; 54: 741-50.
-
(2009)
Histopathology
, vol.54
, pp. 741-750
-
-
Liu, F.1
Lang, R.2
Wei, J.3
-
110
-
-
84856262921
-
The dynamic yin-yang interaction of CXCR4 and CXCR7 in breast cancer metastasis
-
Hawkins OE, Richmond A,. The dynamic yin-yang interaction of CXCR4 and CXCR7 in breast cancer metastasis. Breast Cancer Res 2012; 14: 103.
-
(2012)
Breast Cancer Res
, vol.14
, pp. 103
-
-
Hawkins, O.E.1
Richmond, A.2
-
111
-
-
41149157649
-
TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4
-
Padua D, Zhang XH, Wang Q, et al. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 2008; 133: 66-77.
-
(2008)
Cell
, vol.133
, pp. 66-77
-
-
Padua, D.1
Zhang, X.H.2
Wang, Q.3
-
112
-
-
63049121364
-
The metastatic niche: Adapting the foreign soil
-
Psaila B, Lyden D,. The metastatic niche: adapting the foreign soil. Nat Rev Cancer 2009; 9: 285-93.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 285-293
-
-
Psaila, B.1
Lyden, D.2
-
113
-
-
83555164774
-
S100A8 and S100A9: New insights into their roles in malignancy
-
Srikrishna G,. S100A8 and S100A9: new insights into their roles in malignancy. J Innate Immun 2012; 4: 31-40.
-
(2012)
J Innate Immun
, vol.4
, pp. 31-40
-
-
Srikrishna, G.1
-
114
-
-
80053645045
-
Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation
-
Wong CC, Gilkes DM, Zhang H, et al. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc Natl Acad Sci USA 2011; 108: 16369-74.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 16369-16374
-
-
Wong, C.C.1
Gilkes, D.M.2
Zhang, H.3
-
115
-
-
57849100048
-
Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
-
Erler JT, Bennewith KL, Cox TR, et al. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell 2009; 15: 35-44.
-
(2009)
Cancer Cell
, vol.15
, pp. 35-44
-
-
Erler, J.T.1
Bennewith, K.L.2
Cox, T.R.3
-
116
-
-
79952071069
-
Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation
-
Adam O, Theobald K, Lavall D, et al. Increased lysyl oxidase expression and collagen cross-linking during atrial fibrillation. J Mol Cell Cardiol 2011; 50: 678-85.
-
(2011)
J Mol Cell Cardiol
, vol.50
, pp. 678-685
-
-
Adam, O.1
Theobald, K.2
Lavall, D.3
-
117
-
-
84867924331
-
The metastatic niche and stromal progression
-
Sleeman JP,. The metastatic niche and stromal progression. Cancer Metastasis Rev 2012; 31: 429-40.
-
(2012)
Cancer Metastasis Rev
, vol.31
, pp. 429-440
-
-
Sleeman, J.P.1
-
118
-
-
0035925072
-
Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis
-
Bos R, Zhong H, Hanrahan CF, et al. Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. J Natl Cancer Inst 2001; 93: 309-14.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 309-314
-
-
Bos, R.1
Zhong, H.2
Hanrahan, C.F.3
-
119
-
-
13844276107
-
Correlation of hypoxia inducible factor-1alpha with lymphatic metastasis via vascular endothelial growth factor-C in human esophageal cancer
-
Katsuta M, Miyashita M, Makino H, et al. Correlation of hypoxia inducible factor-1alpha with lymphatic metastasis via vascular endothelial growth factor-C in human esophageal cancer. Exp Mol Pathol 2005; 78: 123-30.
-
(2005)
Exp Mol Pathol
, vol.78
, pp. 123-130
-
-
Katsuta, M.1
Miyashita, M.2
Makino, H.3
-
120
-
-
0037443587
-
Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma
-
Bos R, van der Groep P, Greijer AE, et al. Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 2003; 97: 1573-81.
-
(2003)
Cancer
, vol.97
, pp. 1573-1581
-
-
Bos, R.1
Van Der Groep, P.2
Greijer, A.E.3
-
121
-
-
0034896068
-
Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: Its impact on prognosis and on response to chemotherapy
-
Birner P, Schindl M, Obermair A, et al. Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy. Clin Cancer Res 2001; 7: 1661-8.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1661-1668
-
-
Birner, P.1
Schindl, M.2
Obermair, A.3
-
122
-
-
0035300410
-
Expression of hypoxia-inducible factor-1alpha: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
-
Aebersold DM, Burri P, Beer KT, et al. Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 2001; 61: 2911-16.
-
(2001)
Cancer Res
, vol.61
, pp. 2911-2916
-
-
Aebersold, D.M.1
Burri, P.2
Beer, K.T.3
-
123
-
-
0035395098
-
Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: Its impact on prognosis and on neoangiogenesis
-
Birner P, Gatterbauer B, Oberhuber G, et al. Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis. Cancer 2001; 92: 165-71.
-
(2001)
Cancer
, vol.92
, pp. 165-171
-
-
Birner, P.1
Gatterbauer, B.2
Oberhuber, G.3
-
124
-
-
3142534607
-
Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer
-
Theodoropoulos VE, Lazaris A, Sofras F, et al. Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer. Eur Urol 2004; 46: 200-8.
-
(2004)
Eur Urol
, vol.46
, pp. 200-208
-
-
Theodoropoulos, V.E.1
Lazaris, A.2
Sofras, F.3
-
125
-
-
0038300418
-
Significant correlation of hypoxia-inducible factor-1alpha with treatment outcome in cervical cancer treated with radical radiotherapy
-
Burri P, Djonov V, Aebersold DM, et al. Significant correlation of hypoxia-inducible factor-1alpha with treatment outcome in cervical cancer treated with radical radiotherapy. Int J Radiat Oncol Biol Phys 2003; 56: 494-501.
-
(2003)
Int J Radiat Oncol Biol Phys
, vol.56
, pp. 494-501
-
-
Burri, P.1
Djonov, V.2
Aebersold, D.M.3
-
126
-
-
0036721256
-
Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma
-
Sivridis E, Giatromanolaki A, Gatter KC, et al. Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma. Cancer 2002; 95: 1055-63.
-
(2002)
Cancer
, vol.95
, pp. 1055-1063
-
-
Sivridis, E.1
Giatromanolaki, A.2
Gatter, K.C.3
-
127
-
-
0142175222
-
Hypoxia-inducible factor-1alpha expression and angiogenesis in gastrointestinal stromal tumor of the stomach
-
Takahashi R, Tanaka S, Hiyama T, et al. Hypoxia-inducible factor-1alpha expression and angiogenesis in gastrointestinal stromal tumor of the stomach. Oncol Rep 2003; 10: 797-802.
-
(2003)
Oncol Rep
, vol.10
, pp. 797-802
-
-
Takahashi, R.1
Tanaka, S.2
Hiyama, T.3
-
128
-
-
0142120661
-
Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin
-
Giatromanolaki A, Sivridis E, Kouskoukis C, et al. Hypoxia-inducible factors 1alpha and 2alpha are related to vascular endothelial growth factor expression and a poorer prognosis in nodular malignant melanomas of the skin. Melanoma Res 2003; 13: 493-501.
-
(2003)
Melanoma Res
, vol.13
, pp. 493-501
-
-
Giatromanolaki, A.1
Sivridis, E.2
Kouskoukis, C.3
-
129
-
-
33745138232
-
Regulation of angiogenesis by hypoxia-inducible factor 1
-
Hirota K, Semenza GL,. Regulation of angiogenesis by hypoxia-inducible factor 1. Crit Rev Oncol Hematol 2006; 59: 15-26.
-
(2006)
Crit Rev Oncol Hematol
, vol.59
, pp. 15-26
-
-
Hirota, K.1
Semenza, G.L.2
-
130
-
-
24344488419
-
The HIF pathway in cancer
-
Maxwell PH,. The HIF pathway in cancer. Semin Cell Dev Biol 2005; 16: 523-30.
-
(2005)
Semin Cell Dev Biol
, vol.16
, pp. 523-530
-
-
Maxwell, P.H.1
-
131
-
-
0038282482
-
The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy
-
Unruh A, Ressel A, Mohamed HG, et al. The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy. Oncogene 2003; 22: 3213-20.
-
(2003)
Oncogene
, vol.22
, pp. 3213-3220
-
-
Unruh, A.1
Ressel, A.2
Mohamed, H.G.3
-
132
-
-
2342611976
-
Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules
-
Moeller BJ, Cao Y, Li CY, et al. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. Cancer Cell 2004; 5: 429-41.
-
(2004)
Cancer Cell
, vol.5
, pp. 429-441
-
-
Moeller, B.J.1
Cao, Y.2
Li, C.Y.3
-
133
-
-
0037096732
-
Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene
-
Comerford KM, Wallace TJ, Karhausen J, et al. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res 2002; 62: 3387-94.
-
(2002)
Cancer Res
, vol.62
, pp. 3387-3394
-
-
Comerford, K.M.1
Wallace, T.J.2
Karhausen, J.3
-
134
-
-
2642526992
-
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme
-
Krishnamurthy P, Ross DD, Nakanishi T, et al. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. J Biol Chem 2004; 279: 24218-25.
-
(2004)
J Biol Chem
, vol.279
, pp. 24218-24225
-
-
Krishnamurthy, P.1
Ross, D.D.2
Nakanishi, T.3
-
135
-
-
65649146814
-
BCL-xL is a target gene regulated by hypoxia-inducible factor-1{alpha}
-
Chen N, Chen X, Huang R, et al. BCL-xL is a target gene regulated by hypoxia-inducible factor-1{alpha}. J Biol Chem 2009; 284: 10004-12.
-
(2009)
J Biol Chem
, vol.284
, pp. 10004-10012
-
-
Chen, N.1
Chen, X.2
Huang, R.3
-
136
-
-
12144287046
-
Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance
-
Erler JT, Cawthorne CJ, Williams KJ, et al. Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Mol Cell Biol 2004; 24: 2875-89.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 2875-2889
-
-
Erler, J.T.1
Cawthorne, C.J.2
Williams, K.J.3
-
137
-
-
84868383830
-
Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types
-
Sermeus A, Genin M, Maincent A, et al. Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types. PLoS One 2012; 7: e47519.
-
(2012)
PLoS One
, vol.7
, pp. e47519
-
-
Sermeus, A.1
Genin, M.2
Maincent, A.3
-
138
-
-
65249167552
-
Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation
-
Ma D, Lim T, Xu J, et al. Xenon preconditioning protects against renal ischemic-reperfusion injury via HIF-1alpha activation. J Am Soc Nephrol 2009; 20: 713-20.
-
(2009)
J Am Soc Nephrol
, vol.20
, pp. 713-720
-
-
Ma, D.1
Lim, T.2
Xu, J.3
-
139
-
-
84859445000
-
Hypoxia-inducible factors: Mediators of cancer progression and targets for cancer therapy
-
Semenza GL,. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci 2012; 33: 207-14.
-
(2012)
Trends Pharmacol Sci
, vol.33
, pp. 207-214
-
-
Semenza, G.L.1
-
140
-
-
77956240797
-
Resistance to mammalian target of rapamycin inhibitor therapy in perivascular epithelioid cell tumors
-
Subbiah V, Trent JC, Kurzrock R,. Resistance to mammalian target of rapamycin inhibitor therapy in perivascular epithelioid cell tumors. J Clin Oncol 2010; 28: e415.
-
(2010)
J Clin Oncol
, vol.28
, pp. e415
-
-
Subbiah, V.1
Trent, J.C.2
Kurzrock, R.3
-
141
-
-
57649231823
-
Therapeutic strategy targeting the mTOR-HIF-1alpha-VEGF pathway in ovarian clear cell adenocarcinoma
-
Miyazawa M, Yasuda M, Fujita M, et al. Therapeutic strategy targeting the mTOR-HIF-1alpha-VEGF pathway in ovarian clear cell adenocarcinoma. Pathol Int 2009; 59: 19-27.
-
(2009)
Pathol Int
, vol.59
, pp. 19-27
-
-
Miyazawa, M.1
Yasuda, M.2
Fujita, M.3
-
142
-
-
67650480092
-
MTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
-
Shackelford DB, Vasquez DS, Corbeil J, et al. mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proc Natl Acad Sci USA 2009; 106: 11137-42.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 11137-11142
-
-
Shackelford, D.B.1
Vasquez, D.S.2
Corbeil, J.3
-
143
-
-
25444465116
-
Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function
-
Escuin D, Kline ER, Giannakakou P,. Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function. Cancer Res 2005; 65: 9021-8.
-
(2005)
Cancer Res
, vol.65
, pp. 9021-9028
-
-
Escuin, D.1
Kline, E.R.2
Giannakakou, P.3
-
144
-
-
39549105376
-
2-Methoxyestradiol inhibits hypoxia-inducible factor-1{alpha} and suppresses growth of lesions in a mouse model of endometriosis
-
Becker CM, Rohwer N, Funakoshi T, et al. 2-Methoxyestradiol inhibits hypoxia-inducible factor-1{alpha} and suppresses growth of lesions in a mouse model of endometriosis. Am J Pathol 2008; 172: 534-44.
-
(2008)
Am J Pathol
, vol.172
, pp. 534-544
-
-
Becker, C.M.1
Rohwer, N.2
Funakoshi, T.3
-
145
-
-
79960989122
-
Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1alpha in advanced solid tumors
-
Kummar S, Raffeld M, Juwara L, et al. Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1alpha in advanced solid tumors. Clin Cancer Res 2011; 17: 5123-31.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 5123-5131
-
-
Kummar, S.1
Raffeld, M.2
Juwara, L.3
-
146
-
-
56249131779
-
A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth
-
Greenberger LM, Horak ID, Filpula D, et al. A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth. Mol Cancer Ther 2008; 7: 3598-608.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 3598-3608
-
-
Greenberger, L.M.1
Horak, I.D.2
Filpula, D.3
-
147
-
-
80052691602
-
Potent and sustained inhibition of HIF-1alpha and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects
-
Sapra P, Kraft P, Pastorino F, et al. Potent and sustained inhibition of HIF-1alpha and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects. Angiogenesis 2011; 14: 245-53.
-
(2011)
Angiogenesis
, vol.14
, pp. 245-253
-
-
Sapra, P.1
Kraft, P.2
Pastorino, F.3
-
148
-
-
38349092288
-
Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha
-
Koh MY, Spivak-Kroizman T, Venturini S, et al. Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha. Mol Cancer Ther 2008; 7: 90-100.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 90-100
-
-
Koh, M.Y.1
Spivak-Kroizman, T.2
Venturini, S.3
-
149
-
-
58149374576
-
Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth
-
Zhang H, Qian DZ, Tan YS, et al. Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc Natl Acad Sci USA 2008; 105: 19579-86.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19579-19586
-
-
Zhang, H.1
Qian, D.Z.2
Tan, Y.S.3
-
150
-
-
77956286559
-
Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion
-
Terzuoli E, Puppo M, Rapisarda A, et al. Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion. Cancer Res 2010; 70: 6837-48.
-
(2010)
Cancer Res
, vol.70
, pp. 6837-6848
-
-
Terzuoli, E.1
Puppo, M.2
Rapisarda, A.3
-
151
-
-
78651338243
-
Microtubule disruption targets HIF-1alpha mRNA to cytoplasmic P-bodies for translational repression
-
Carbonaro M, O'Brate A, Giannakakou P,. Microtubule disruption targets HIF-1alpha mRNA to cytoplasmic P-bodies for translational repression. J Cell Biol 2011; 192: 83-99.
-
(2011)
J Cell Biol
, vol.192
, pp. 83-99
-
-
Carbonaro, M.1
O'Brate, A.2
Giannakakou, P.3
-
152
-
-
33846254999
-
RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha
-
Liu YV, Baek JH, Zhang H, et al. RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. Mol Cell 2007; 25: 207-17.
-
(2007)
Mol Cell
, vol.25
, pp. 207-217
-
-
Liu, Y.V.1
Baek, J.H.2
Zhang, H.3
-
153
-
-
33745637200
-
Effects of geldanamycin on HIF-1alpha mediated angiogenesis and invasion in prostate cancer cells
-
Alqawi O, Moghaddas M, Singh G,. Effects of geldanamycin on HIF-1alpha mediated angiogenesis and invasion in prostate cancer cells. Prostate Cancer Prostatic Dis 2006; 9: 126-35.
-
(2006)
Prostate Cancer Prostatic Dis
, vol.9
, pp. 126-135
-
-
Alqawi, O.1
Moghaddas, M.2
Singh, G.3
-
154
-
-
77955037416
-
Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer
-
Kuiper C, Molenaar IG, Dachs GU, et al. Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer. Cancer Res 2010; 70: 5749-58.
-
(2010)
Cancer Res
, vol.70
, pp. 5749-5758
-
-
Kuiper, C.1
Molenaar, I.G.2
Dachs, G.U.3
-
155
-
-
79251576774
-
Histone deacetylase inhibitors: The epigenetic therapeutics that repress hypoxia-inducible factors
-
Chen S, Sang N,. Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors. J Biomed Biotechnol 2011; 2011: 197946.
-
(2011)
J Biomed Biotechnol
, vol.2011
, pp. 197946
-
-
Chen, S.1
Sang, N.2
-
156
-
-
70449580319
-
Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
-
Lee K, Zhang H, Qian DZ, et al. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proc Natl Acad Sci USA 2009; 106: 17910-15.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 17910-17915
-
-
Lee, K.1
Zhang, H.2
Qian, D.Z.3
-
157
-
-
33746496671
-
Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1alpha C-terminal activation domain
-
Kaluz S, Kaluzova M, Stanbridge EJ,. Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1alpha C-terminal activation domain. Mol Cell Biol 2006; 26: 5895-907.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 5895-5907
-
-
Kaluz, S.1
Kaluzova, M.2
Stanbridge, E.J.3
-
158
-
-
3142622930
-
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
-
Kung AL, Zabludoff SD, France DS, et al. Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell 2004; 6: 33-43.
-
(2004)
Cancer Cell
, vol.6
, pp. 33-43
-
-
Kung, A.L.1
Zabludoff, S.D.2
France, D.S.3
-
159
-
-
0037414180
-
YC-1: A potential anticancer drug targeting hypoxia-inducible factor 1
-
Yeo EJ, Chun YS, Cho YS, et al. YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst 2003; 95: 516-25.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 516-525
-
-
Yeo, E.J.1
Chun, Y.S.2
Cho, Y.S.3
-
160
-
-
25444523184
-
Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity
-
Kong D, Park EJ, Stephen AG, et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res 2005; 65: 9047-55.
-
(2005)
Cancer Res
, vol.65
, pp. 9047-9055
-
-
Kong, D.1
Park, E.J.2
Stephen, A.G.3
-
161
-
-
60549092506
-
Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells
-
Lee K, Qian DZ, Rey S, et al. Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells. Proc Natl Acad Sci USA 2009; 106: 2353-8.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 2353-2358
-
-
Lee, K.1
Qian, D.Z.2
Rey, S.3
-
162
-
-
33749546461
-
Identification of novel small-molecule inhibitors of hypoxia-inducible factor-1 transactivation and DNA binding
-
Jones DT, Harris AL,. Identification of novel small-molecule inhibitors of hypoxia-inducible factor-1 transactivation and DNA binding. Mol Cancer Ther 2006; 5: 2193-202.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2193-2202
-
-
Jones, D.T.1
Harris, A.L.2
-
163
-
-
84863422466
-
Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia
-
Rapisarda A, Melillo G,. Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia. Nat Rev Clin Oncol 2012; 9: 378-90.
-
(2012)
Nat Rev Clin Oncol
, vol.9
, pp. 378-390
-
-
Rapisarda, A.1
Melillo, G.2
-
164
-
-
84872425530
-
HIF-1alpha activation mediates resistance to anti-angiogenic therapy in neuroblastoma xenografts
-
Hartwich J, Orr WS, Ng CY, et al. HIF-1alpha activation mediates resistance to anti-angiogenic therapy in neuroblastoma xenografts. J Pediatr Surg 2013; 48: 39-46.
-
(2013)
J Pediatr Surg
, vol.48
, pp. 39-46
-
-
Hartwich, J.1
Orr, W.S.2
Ng, C.Y.3
-
165
-
-
84875405981
-
Gambogic acid inhibits angiogenesis through inhibiting PHD2-VHL-HIF-1alpha pathway
-
Lu N, Hui H, Yang H, et al. Gambogic acid inhibits angiogenesis through inhibiting PHD2-VHL-HIF-1alpha pathway. Eur J Pharm Sci 2013; 49: 220-6.
-
(2013)
Eur J Pharm Sci
, vol.49
, pp. 220-226
-
-
Lu, N.1
Hui, H.2
Yang, H.3
-
166
-
-
84860782631
-
The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function
-
Baker LC, Boult JK, Walker-Samuel S, et al. The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function. Br J Cancer 2012; 106: 1638-47.
-
(2012)
Br J Cancer
, vol.106
, pp. 1638-1647
-
-
Baker, L.C.1
Boult, J.K.2
Walker-Samuel, S.3
-
167
-
-
84875790987
-
Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells
-
Han WQ, Zhu Q, Hu J, et al. Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells. Biochim Biophys Acta 2013; 1833: 1454-62.
-
(2013)
Biochim Biophys Acta
, vol.1833
, pp. 1454-1462
-
-
Han, W.Q.1
Zhu, Q.2
Hu, J.3
-
168
-
-
79952165882
-
VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration
-
Razorenova OV, Finger EC, Colavitti R, et al. VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Proc Natl Acad Sci USA 2011; 108: 1931-6.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 1931-1936
-
-
Razorenova, O.V.1
Finger, E.C.2
Colavitti, R.3
-
169
-
-
0035054565
-
Genotype-phenotype correlation in von Hippel-Lindau syndrome
-
Friedrich CA,. Genotype-phenotype correlation in von Hippel-Lindau syndrome. Hum Mol Genet 2001; 10: 763-7.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 763-767
-
-
Friedrich, C.A.1
-
170
-
-
0035394516
-
Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas
-
Wiesener MS, Munchenhagen PM, Berger I, et al. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1alpha in clear cell renal carcinomas. Cancer Res 2001; 61: 5215-22.
-
(2001)
Cancer Res
, vol.61
, pp. 5215-5222
-
-
Wiesener, M.S.1
Munchenhagen, P.M.2
Berger, I.3
-
171
-
-
0037395395
-
Gene expression profiling in a renal cell carcinoma cell line: Dissecting VHL and hypoxia-dependent pathways
-
Jiang Y, Zhang W, Kondo K, et al. Gene expression profiling in a renal cell carcinoma cell line: dissecting VHL and hypoxia-dependent pathways. Mol Cancer Res 2003; 1: 453-62.
-
(2003)
Mol Cancer Res
, vol.1
, pp. 453-462
-
-
Jiang, Y.1
Zhang, W.2
Kondo, K.3
-
172
-
-
0038274803
-
Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer
-
Terakawa N, Kanamori Y, Yoshida S,. Loss of PTEN expression followed by Akt phosphorylation is a poor prognostic factor for patients with endometrial cancer. Endocr Relat Cancer 2003; 10: 203-8.
-
(2003)
Endocr Relat Cancer
, vol.10
, pp. 203-208
-
-
Terakawa, N.1
Kanamori, Y.2
Yoshida, S.3
-
173
-
-
16544383044
-
The mTOR/S6K signalling pathway: The role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb
-
discussion 54-9
-
Nobukini T, Thomas G,. The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb. Novartis Found Symp 2004; 262: 148-54; discussion 54-9, 265-8.
-
(2004)
Novartis Found Symp
, vol.262
, pp. 148-154
-
-
Nobukini, T.1
Thomas, G.2
-
174
-
-
79960052850
-
Ras in cancer and developmental diseases
-
Fernandez-Medarde A, Santos E,. Ras in cancer and developmental diseases. Genes Cancer 2011; 2: 344-58.
-
(2011)
Genes Cancer
, vol.2
, pp. 344-358
-
-
Fernandez-Medarde, A.1
Santos, E.2
|