MET inhibition in tumor cells by PHA665752 impairs homologous recombination repair of DNA double strand breaks

International Journal of Cancer

Volumn 130, Issue 3, 2012, Pages 728-734

  Medová, Michaela ^a   Aebersold, Daniel M ^a   Zimmer, Yitzhak ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

homologous recombination; MET; tyrosine kinase inhibitor

Indexed keywords

5 (2,6 DICHLOROBENZYLSULFONYL) 3 [3,5 DIMETHYL 4 [2 (1 PYRROLIDINYLMETHYL) 1 PYRROLIDINYLCARBONYL] 1H PYRROL 2 YLMETHYLENE] 1,3 DIHYDRO 2H INDOL 2 ONE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; RAD51 BRCA2 PROTEIN; RAD51 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE OVEREXPRESSION; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; ONCOGENE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TUMOR CELL;

ANIMALS; ANTINEOPLASTIC AGENTS; BRCA2 PROTEIN; CELL CYCLE; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; DNA BREAKS, DOUBLE-STRANDED; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INDOLES; MICE; MUTATION; NEOPLASMS; NIH 3T3 CELLS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-MET; RAD51 RECOMBINASE; RECOMBINATIONAL DNA REPAIR; SULFONES;

EID: 82255163062     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.26058     Document Type: Article

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