Decorin antagonizes the angiogenic network: Concurrent inhibition of met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and tiMP3

Journal of Biological Chemistry

Volumn 287, Issue 8, 2012, Pages 5492-5506

  Neill, Thomas ^a   Painter, Hannah ^a   Buraschi, Simone ^a   Owens, Rick T ^c   Lisanti, Michael P ^b   Schaefer, Liliana ^d   Iozzo, Renato V ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c LIFECELL CORPORATION   (United States)

^d GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CARCINOMA CELLS; CATENIN SIGNALING; DECORIN; ENZYMATIC ACTIVITIES; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTORS; MATRIX METALLOPROTEASE; MULTIPLE RECEPTORS; PCR ARRAYS; PROTEOGLYCANS; TUMOR ANGIOGENESIS; TUMOR GROWTH; VASCULAR ENDOTHELIAL GROWTH FACTOR;

AMINO ACIDS; ENZYME ACTIVITY; GENES; TUMORS;

GLYCOPROTEINS;

DECORIN; GELATINASE A; GELATINASE B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; THROMBOSPONDIN 1; TISSUE INHIBITOR OF METALLOPROTEINASE 3; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MINERALIZATION; BREAST TUMOR; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME REPRESSION; FEMALE; GENE EXPRESSION REGULATION; GENE PRODUCT; GENETIC STABILITY; HIF1A GENE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; UPREGULATION;

ANIMALS; CELL LINE, TUMOR; DECORIN; DOWN-REGULATION; ENZYME INDUCTION; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MATRIX METALLOPROTEINASES; MICE; NEOVASCULARIZATION, PATHOLOGIC; PROTO-ONCOGENE PROTEINS C-MET; SIGNAL TRANSDUCTION; THROMBOSPONDIN 1; TISSUE INHIBITOR OF METALLOPROTEINASE-3; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84857308088     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.283499     Document Type: Article

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