Extended ischemia prevents HIF1α degradation at reoxygenation by impairing prolyl-hydroxylation: Role of krebs cycle metabolites

Journal of Biological Chemistry

Volumn 285, Issue 24, 2010, Pages 18217-18224

  Serra Pérez, Anna ^a   Planas, Anna M ^a   Núñez O'Mara, Analía ^b   Berra, Edurne ^b   García Villoria, Judit ^c   Ribes, Antònia ^c   Santalucía, Tomàs ^a  

^a INST D INVESTIGACIONS B   (Spain)

^b CIC BIOGUNE   (Spain)

^c INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; GLUCOSE; HYDROXYLATION; METABOLISM; METABOLITES; OXIDATION;

CELLULAR RESPONSE; GLUCOSE DEPRIVATION; HYPOXIA-INDUCIBLE FACTORS; METABOLIC PATHWAYS; MODULATING EFFECT; NEUROBLASTOMA CELLS; OXYGEN DEPRIVATION; TRANSCRIPTIONAL ACTIVITY;

OXYGEN;

2 OXOGLUTARIC ACID; FUMARIC ACID; GLUCOSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGEN; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; SUCCINIC ACID;

ARTICLE; BRAIN ISCHEMIA; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROXYLATION; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM; REOXYGENATION;

EID: 77953319433     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.101048     Document Type: Article

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