메뉴 건너뛰기




Volumn 5, Issue 1, 2015, Pages 23-42

Nucleic acid aptamer-guided cancer therapeutics and diagnostics: The next generation of cancer medicine

Author keywords

Active targeting; Aptamer; Cancer stem cell; Cancer theranostic; Cancer therapy; Chemoresistance

Indexed keywords

APTAMER; ARABINOGALACTAN; AS 1411 APTAMER; CL.42 APTAMER; DNA APTAMER NAS 24; DOCETAXEL; DOXORUBICIN; EPIRUBICIN; GEMCITABINE; LIPOSOME; MACROGOL POLYGLACTIN NANOPARTICLE; MICRORNA; NANOPARTICLE; PACLITAXEL; RAPAMYCIN; RNA APTAMER; RNA INDUCED SILENCING COMPLEX; SGC8C APTAMER; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE; TLS11A GC APTAMER; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE; UNCLASSIFIED DRUG; VIMENTIN; ANTINEOPLASTIC AGENT;

EID: 84924284243     PISSN: None     EISSN: 18387640     Source Type: Journal    
DOI: 10.7150/thno.10202     Document Type: Review
Times cited : (192)

References (219)
  • 1
    • 84893710592 scopus 로고    scopus 로고
    • Cancer stem cells: A contentious hypothesis now moving forward
    • O'Connor ML, Xiang D, Shigdar S, et al. Cancer stem cells: A contentious hypothesis now moving forward. Cancer Lett. 2014; 344: 180-7.
    • (2014) Cancer Lett , vol.344 , pp. 180-187
    • O'Connor, M.L.1    Xiang, D.2    Shigdar, S.3
  • 2
    • 84901853867 scopus 로고    scopus 로고
    • Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance
    • Easwaran H, Tsai HC, Baylin SB. Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance. Mol Cell. 2014; 54: 716-27.
    • (2014) Mol Cell , vol.54 , pp. 716-727
    • Easwaran, H.1    Tsai, H.C.2    Baylin, S.B.3
  • 3
    • 84885364568 scopus 로고    scopus 로고
    • Aptamers as theranostic agents: modifications, serum stability and functionalisation
    • Shigdar S, Macdonald J, O'Connor M, et al. Aptamers as theranostic agents: modifications, serum stability and functionalisation. Sensors. 2013; 13: 13624-37.
    • (2013) Sensors , vol.13 , pp. 13624-13637
    • Shigdar, S.1    Macdonald, J.2    O'Connor, M.3
  • 4
    • 79959393938 scopus 로고    scopus 로고
    • Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies
    • Chauhan VP, Stylianopoulos T, Boucher Y, et al. Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies. Annu Rev Chem Biomol Eng. 2011; 2: 281-98.
    • (2011) Annu Rev Chem Biomol Eng , vol.2 , pp. 281-298
    • Chauhan, V.P.1    Stylianopoulos, T.2    Boucher, Y.3
  • 5
    • 84876993950 scopus 로고    scopus 로고
    • Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers
    • Jain RK. Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. J Clin Oncol. 2013; 31: 2205-18.
    • (2013) J Clin Oncol , vol.31 , pp. 2205-2218
    • Jain, R.K.1
  • 6
    • 0016365091 scopus 로고
    • Distribution of anticancer agents in spontaneous animal tumors I. Regional blood flow and methotrexate distribution in canine lymphosarcoma
    • Straw JA, Hart MM, Klubes P, et al. Distribution of anticancer agents in spontaneous animal tumors. I. Regional blood flow and methotrexate distribution in canine lymphosarcoma. J Natl Cancer Inst. 1974; 52: 1327-31.
    • (1974) J Natl Cancer Inst , vol.52 , pp. 1327-1331
    • Straw, J.A.1    Hart, M.M.2    Klubes, P.3
  • 7
    • 0016801227 scopus 로고
    • Distribution of anticancer agents in spontaneous animal tumors II. Distribution of gallium in canine lymphosarcoma
    • Straw JA, Klubes P, Hart MM. Distribution of anticancer agents in spontaneous animal tumors. II. Distribution of gallium in canine lymphosarcoma. J Natl Cancer Inst. 1975; 55: 199-202.
    • (1975) J Natl Cancer Inst , vol.55 , pp. 199-202
    • Straw, J.A.1    Klubes, P.2    Hart, M.M.3
  • 8
    • 84894568529 scopus 로고    scopus 로고
    • Lymphangiogenesis and lymphatic vessel remodelling in cancer
    • Stacker SA, Williams SP, Karnezis T, et al. Lymphangiogenesis and lymphatic vessel remodelling in cancer. Nat Rev Cancer. 2014; 14: 159-72.
    • (2014) Nat Rev Cancer , vol.14 , pp. 159-172
    • Stacker, S.A.1    Williams, S.P.2    Karnezis, T.3
  • 10
    • 84857422770 scopus 로고    scopus 로고
    • A heterogeneous in vitro three dimensional model of tumor-stroma interactions regulating sprouting angiogenesis
    • Correa de Sampaio P, Auslaender D, Krubasik D, et al. A heterogeneous in vitro three dimensional model of tumor-stroma interactions regulating sprouting angiogenesis. PLoS One. 2012; 7: e30753.
    • (2012) PLoS One , vol.7
    • Correa de Sampaio, P.1    Auslaender, D.2    Krubasik, D.3
  • 11
    • 84896754346 scopus 로고    scopus 로고
    • Lymphatic vessels and tertiary lymphoid organs
    • Ruddle NH. Lymphatic vessels and tertiary lymphoid organs. J Clin Invest. 2014; 124: 953-9.
    • (2014) J Clin Invest , vol.124 , pp. 953-959
    • Ruddle, N.H.1
  • 12
    • 84896747626 scopus 로고    scopus 로고
    • Mechanisms of lymphatic metastasis
    • Karaman S, Detmar M. Mechanisms of lymphatic metastasis. J Clin Invest. 2014; 124: 922-8.
    • (2014) J Clin Invest , vol.124 , pp. 922-928
    • Karaman, S.1    Detmar, M.2
  • 13
    • 79953054576 scopus 로고    scopus 로고
    • The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect
    • Fang J, Nakamura H, Maeda H. The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv Drug Deliv Rev. 2011; 63: 136-51.
    • (2011) Adv Drug Deliv Rev , vol.63 , pp. 136-151
    • Fang, J.1    Nakamura, H.2    Maeda, H.3
  • 14
    • 84870236985 scopus 로고    scopus 로고
    • Anticancer nanomedicine and tumor vascular permeability; Where is the missing link?
    • Taurin S, Nehoff H, Greish K. Anticancer nanomedicine and tumor vascular permeability; Where is the missing link? J Control Release. 2012; 164: 265-75.
    • (2012) J Control Release , vol.164 , pp. 265-275
    • Taurin, S.1    Nehoff, H.2    Greish, K.3
  • 15
    • 33645738314 scopus 로고    scopus 로고
    • Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis
    • Hagendoorn J, Tong R, Fukumura D, et al. Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis. Cancer Res. 2006; 66: 3360-4.
    • (2006) Cancer Res , vol.66 , pp. 3360-3364
    • Hagendoorn, J.1    Tong, R.2    Fukumura, D.3
  • 16
    • 84881110925 scopus 로고    scopus 로고
    • Interstitial fluid flow and drug delivery in vascularized tumors: a computational model
    • Welter M, Rieger H. Interstitial fluid flow and drug delivery in vascularized tumors: a computational model. PLoS One. 2013; 8: e70395.
    • (2013) PLoS One , vol.8
    • Welter, M.1    Rieger, H.2
  • 17
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fluid pressure - an obstacle in cancer therapy
    • Heldin C-H, Rubin K, Pietras K, et al. High interstitial fluid pressure - an obstacle in cancer therapy. Nat Rev Cancer. 2004; 4: 806-13.
    • (2004) Nat Rev Cancer , vol.4 , pp. 806-813
    • Heldin, C.-H.1    Rubin, K.2    Pietras, K.3
  • 18
    • 84901290212 scopus 로고    scopus 로고
    • Releasing pressure in tumors: what do we know so far and where do we go from here? A review
    • Ariffin AB, Forde PF, Jahangeer S, et al. Releasing pressure in tumors: what do we know so far and where do we go from here? A review. Cancer Res. 2014; 74: 2655-62.
    • (2014) Cancer Res , vol.74 , pp. 2655-2662
    • Ariffin, A.B.1    Forde, P.F.2    Jahangeer, S.3
  • 19
    • 84880079914 scopus 로고    scopus 로고
    • Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse
    • Stylianopoulos T, Martin JD, Snuderl M, et al. Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse. Cancer Res. 2013; 73: 3833-41.
    • (2013) Cancer Res , vol.73 , pp. 3833-3841
    • Stylianopoulos, T.1    Martin, J.D.2    Snuderl, M.3
  • 20
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fluid pressure - an obstacle in cancer therapy
    • Heldin CH, Rubin K, Pietras K, et al. High interstitial fluid pressure - an obstacle in cancer therapy. Nat Rev Cancer. 2004; 4: 806-13.
    • (2004) Nat Rev Cancer , vol.4 , pp. 806-813
    • Heldin, C.H.1    Rubin, K.2    Pietras, K.3
  • 21
  • 22
  • 23
    • 84904856656 scopus 로고    scopus 로고
    • Intratumor Heterogeneity and Its Impact on Drug Distribution and Sensitivity
    • Fuso Nerini I, Morosi L, Zucchetti M, et al. Intratumor Heterogeneity and Its Impact on Drug Distribution and Sensitivity. Clin Pharmacol Ther. 2014; 96: 224-38.
    • (2014) Clin Pharmacol Ther , vol.96 , pp. 224-238
    • Fuso Nerini, I.1    Morosi, L.2    Zucchetti, M.3
  • 24
    • 84892419425 scopus 로고    scopus 로고
    • Towards an integrated systems-based modelling framework for drug transport and its effect on tumor cells
    • Liu C, Krishnan, Xu XY. Towards an integrated systems-based modelling framework for drug transport and its effect on tumor cells. J Biol Eng. 2014; 8: 3.
    • (2014) J Biol Eng , vol.8 , pp. 3
    • Krishnan, L.C.1    Xu, X.Y.2
  • 25
    • 0036708471 scopus 로고    scopus 로고
    • Diffusion and convection in collagen gels: implications for transport in the tumor interstitium
    • Ramanujan S, Pluen A, McKee TD, et al. Diffusion and convection in collagen gels: implications for transport in the tumor interstitium. Biophys J. 2002; 83: 1650-60.
    • (2002) Biophys J , vol.83 , pp. 1650-1660
    • Ramanujan, S.1    Pluen, A.2    McKee, T.D.3
  • 26
    • 0141790758 scopus 로고    scopus 로고
    • Drug delivery and transport to solid tumors
    • Jang SH, Wientjes MG, Lu D, et al. Drug delivery and transport to solid tumors. Pharm Res. 2003; 20: 1337-50.
    • (2003) Pharm Res , vol.20 , pp. 1337-1350
    • Jang, S.H.1    Wientjes, M.G.2    Lu, D.3
  • 27
    • 84861809558 scopus 로고    scopus 로고
    • Near-infrared light-triggered, targeted drug delivery to cancer cells by aptamer gated nanovehicles
    • Yang X, Liu X, Liu Z, et al. Near-infrared light-triggered, targeted drug delivery to cancer cells by aptamer gated nanovehicles. Adv Mater. 2012; 24: 2890-5.
    • (2012) Adv Mater , vol.24 , pp. 2890-2895
    • Yang, X.1    Liu, X.2    Liu, Z.3
  • 28
    • 84902163612 scopus 로고    scopus 로고
    • Magnetic Resonance Imaging of the Tumor Microenvironment in Radiotherapy: Perfusion, Hypoxia, and Metabolism
    • Matsuo M, Matsumoto S, Mitchell JB, et al. Magnetic Resonance Imaging of the Tumor Microenvironment in Radiotherapy: Perfusion, Hypoxia, and Metabolism. Semin Radiat Oncol. 2014; 24: 210-17.
    • (2014) Semin Radiat Oncol , vol.24 , pp. 210-217
    • Matsuo, M.1    Matsumoto, S.2    Mitchell, J.B.3
  • 29
    • 84901493119 scopus 로고    scopus 로고
    • The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance
    • Kharaishvili G, Simkova D, Bouchalova K, et al. The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance. Cancer Cell Int. 2014; 14: 41.
    • (2014) Cancer Cell Int , vol.14 , pp. 41
    • Kharaishvili, G.1    Simkova, D.2    Bouchalova, K.3
  • 30
    • 84880712433 scopus 로고    scopus 로고
    • Barriers to drug delivery in interventional oncology
    • Sheth RA, Hesketh R, Kong DS, et al. Barriers to drug delivery in interventional oncology. J Vasc Interv Radiol. 2013; 24: 1201-7.
    • (2013) J Vasc Interv Radiol , vol.24 , pp. 1201-1207
    • Sheth, R.A.1    Hesketh, R.2    Kong, D.S.3
  • 31
    • 84896789192 scopus 로고    scopus 로고
    • Matrix as an interstitial transport system
    • Fan D, Creemers EE, Kassiri Z. Matrix as an interstitial transport system. Circ Res. 2014; 114: 889-902.
    • (2014) Circ Res , vol.114 , pp. 889-902
    • Fan, D.1    Creemers, E.E.2    Kassiri, Z.3
  • 32
    • 0037112419 scopus 로고    scopus 로고
    • High-frequency Doppler ultrasound monitors the effects of antivascular therapy on tumor blood flow
    • Goertz DE, Yu JL, Kerbel RS, et al. High-frequency Doppler ultrasound monitors the effects of antivascular therapy on tumor blood flow. Cancer Res. 2002; 62: 6371-5.
    • (2002) Cancer Res , vol.62 , pp. 6371-6375
    • Goertz, D.E.1    Yu, J.L.2    Kerbel, R.S.3
  • 33
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR, Galli SJ, Dvorak AM, et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science. 1983; 219: 983-5.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3
  • 34
    • 84891112609 scopus 로고    scopus 로고
    • Vascular permeability and drug delivery in cancers
    • Azzi S, Hebda JK, Gavard J. Vascular permeability and drug delivery in cancers. Front Oncol. 2013; 3: 211.
    • (2013) Front Oncol , vol.3 , pp. 211
    • Azzi, S.1    Hebda, J.K.2    Gavard, J.3
  • 35
    • 84872387034 scopus 로고    scopus 로고
    • Role of macrophage polarization in tumor angiogenesis and vessel normalization: implications for new anticancer therapies
    • Chen P, Bonaldo P. Role of macrophage polarization in tumor angiogenesis and vessel normalization: implications for new anticancer therapies. Int Rev Cell Mol Biol. 2013; 301: 1-35.
    • (2013) Int Rev Cell Mol Biol , vol.301 , pp. 1-35
    • Chen, P.1    Bonaldo, P.2
  • 36
    • 84890390421 scopus 로고    scopus 로고
    • pH-sensitive drug-delivery systems for tumor targeting
    • He X, Li J, An S, et al. pH-sensitive drug-delivery systems for tumor targeting. Ther Deliv. 2013; 4: 1499-510.
    • (2013) Ther Deliv , vol.4 , pp. 1499-1510
    • He, X.1    Li, J.2    An, S.3
  • 37
    • 84893639632 scopus 로고    scopus 로고
    • Acidic priming enhances metastatic potential of cancer cells
    • [Epub ahead of print]
    • Riemann A, Schneider B, Gundel D, et al. Acidic priming enhances metastatic potential of cancer cells. Pflugers Arch. 2014; doi: 10.1007/s00424-014-1458-6. [Epub ahead of print].
    • (2014) Pflugers Arch
    • Riemann, A.1    Schneider, B.2    Gundel, D.3
  • 38
    • 0022481177 scopus 로고
    • Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors
    • Rotin D, Robinson B, Tannock IF. Influence of hypoxia and an acidic environment on the metabolism and viability of cultured cells: potential implications for cell death in tumors. Cancer Res. 1986; 46: 2821-6.
    • (1986) Cancer Res , vol.46 , pp. 2821-2826
    • Rotin, D.1    Robinson, B.2    Tannock, I.F.3
  • 39
    • 0021732164 scopus 로고
    • The relevance of tumor pH to the treatment of malignant disease
    • Wike-Hooley JL, Haveman J, Reinhold HS. The relevance of tumor pH to the treatment of malignant disease. Radiother Oncol. 1984; 2: 343-66.
    • (1984) Radiother Oncol , vol.2 , pp. 343-366
    • Wike-Hooley, J.L.1    Haveman, J.2    Reinhold, H.S.3
  • 40
    • 0025074907 scopus 로고
    • In vitro selection of RNA molecules that bind specific ligands
    • Ellington AD, Szostak JW. In vitro selection of RNA molecules that bind specific ligands. Nature. 1990; 346: 818-22.
    • (1990) Nature , vol.346 , pp. 818-822
    • Ellington, A.D.1    Szostak, J.W.2
  • 41
    • 84874548546 scopus 로고    scopus 로고
    • The use of sensitive chemical antibodies for diagnosis: detection of low levels of epcam in breast cancer
    • Shigdar S, Qian C, Lv L, et al. The use of sensitive chemical antibodies for diagnosis: detection of low levels of epcam in breast cancer. PLoS One. 2013; 8: e57613.
    • (2013) PLoS One , vol.8
    • Shigdar, S.1    Qian, C.2    Lv, L.3
  • 42
    • 77956876990 scopus 로고    scopus 로고
    • Targeting cancer cells with nucleic acid aptamers
    • Cerchia L, de Franciscis V. Targeting cancer cells with nucleic acid aptamers. Trends Biotechnol. 2010; 28: 517-25.
    • (2010) Trends Biotechnol , vol.28 , pp. 517-525
    • Cerchia, L.1    de Franciscis, V.2
  • 43
    • 0035810165 scopus 로고    scopus 로고
    • Functional proteins from a random-sequence library
    • Keefe AD, Szostak JW. Functional proteins from a random-sequence library. Nature. 2001; 410: 715-8.
    • (2001) Nature , vol.410 , pp. 715-718
    • Keefe, A.D.1    Szostak, J.W.2
  • 44
    • 74049140005 scopus 로고    scopus 로고
    • In vivo selection of tumor-targeting RNA motifs
    • Mi J, Liu Y, Rabbani ZN, et al. In vivo selection of tumor-targeting RNA motifs. Nat Chem Biol. 2010; 6: 22-4.
    • (2010) Nat Chem Biol , vol.6 , pp. 22-24
    • Mi, J.1    Liu, Y.2    Rabbani, Z.N.3
  • 45
    • 84878869042 scopus 로고    scopus 로고
    • In vivo SELEX for Identification of Brain-penetrating Aptamers
    • Cheng C, Chen YH, Lennox KA, et al. In vivo SELEX for Identification of Brain-penetrating Aptamers. Mol Ther Nucleic Acids. 2013; 2: e67.
    • (2013) Mol Ther Nucleic Acids , vol.2
    • Cheng, C.1    Chen, Y.H.2    Lennox, K.A.3
  • 46
    • 0033982759 scopus 로고    scopus 로고
    • Combinatorial protein reagents to manipulate protein function
    • Colas P. Combinatorial protein reagents to manipulate protein function. Curr Opin Chem Biol. 2000; 4: 54-9.
    • (2000) Curr Opin Chem Biol , vol.4 , pp. 54-59
    • Colas, P.1
  • 47
    • 22744446011 scopus 로고    scopus 로고
    • Pegaptanib: the first antiangiogenic agent approved for neovascular macular degeneration
    • Doggrell SA. Pegaptanib: the first antiangiogenic agent approved for neovascular macular degeneration. Expert Opin Pharmacother. 2005; 6: 1421-3.
    • (2005) Expert Opin Pharmacother , vol.6 , pp. 1421-1423
    • Doggrell, S.A.1
  • 48
    • 0033790673 scopus 로고    scopus 로고
    • Escort aptamers: a delivery service for diagnosis and therapy
    • Hicke BJ, Stephens AW. Escort aptamers: a delivery service for diagnosis and therapy. J Clin Invest. 2000; 106: 923-8.
    • (2000) J Clin Invest , vol.106 , pp. 923-928
    • Hicke, B.J.1    Stephens, A.W.2
  • 49
    • 79954858874 scopus 로고    scopus 로고
    • RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule
    • Shigdar S, Lin J, Yu Y, et al. RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule. Cancer Sci. 2011; 102: 991-8.
    • (2011) Cancer Sci , vol.102 , pp. 991-998
    • Shigdar, S.1    Lin, J.2    Yu, Y.3
  • 50
    • 28444484636 scopus 로고    scopus 로고
    • Aptamers--basic research, drug development, and clinical applications
    • Proske D, Blank M, Buhmann R, et al. Aptamers--basic research, drug development, and clinical applications. Appl Microbiol Biotechnol. 2005; 69: 367-74.
    • (2005) Appl Microbiol Biotechnol , vol.69 , pp. 367-374
    • Proske, D.1    Blank, M.2    Buhmann, R.3
  • 51
    • 84875287450 scopus 로고    scopus 로고
    • A review of therapeutic aptamer conjugates with emphasis on new approaches
    • Bruno JG. A review of therapeutic aptamer conjugates with emphasis on new approaches. Pharmaceuticals (Basel). 2013; 6: 340-57.
    • (2013) Pharmaceuticals (Basel) , vol.6 , pp. 340-357
    • Bruno, J.G.1
  • 52
    • 84865416584 scopus 로고    scopus 로고
    • Targeted delivery of chemotherapy agents using a liver cancer-specific aptamer
    • Meng L, Yang L, Zhao X, et al. Targeted delivery of chemotherapy agents using a liver cancer-specific aptamer. PLoS One. 2012; 7: e33434.
    • (2012) PLoS One , vol.7
    • Meng, L.1    Yang, L.2    Zhao, X.3
  • 53
    • 84930480661 scopus 로고    scopus 로고
    • Assessing the real-world cost-effectiveness of adjuvant trastuzumab in HER-2/neu positive breast cancer
    • Hedden L, O'Reilly S, Lohrisch C, et al. Assessing the real-world cost-effectiveness of adjuvant trastuzumab in HER-2/neu positive breast cancer. Oncologist. 2012; 17: 164-71.
    • (2012) Oncologist , vol.17 , pp. 164-171
    • Hedden, L.1    O'Reilly, S.2    Lohrisch, C.3
  • 54
    • 84859727619 scopus 로고    scopus 로고
    • Trastuzumab for HER2-Positive Metastatic Breast Cancer: Clinical and Economic Considerations
    • Jeyakumar A, Younis T. Trastuzumab for HER2-Positive Metastatic Breast Cancer: Clinical and Economic Considerations. Clin Med Insights Oncol. 2012; 6: 179-87.
    • (2012) Clin Med Insights Oncol , vol.6 , pp. 179-187
    • Jeyakumar, A.1    Younis, T.2
  • 55
    • 46049088681 scopus 로고    scopus 로고
    • Applications of aptamers in cancer cell biology
    • Phillips JA, Lopez-Colon D, Zhu Z, et al. Applications of aptamers in cancer cell biology. Anal Chim Acta. 2008; 621: 101-8.
    • (2008) Anal Chim Acta , vol.621 , pp. 101-108
    • Phillips, J.A.1    Lopez-Colon, D.2    Zhu, Z.3
  • 56
    • 0032860385 scopus 로고    scopus 로고
    • Aptamers: an emerging class of molecules that rival antibodies in diagnostics
    • Jayasena SD. Aptamers: an emerging class of molecules that rival antibodies in diagnostics. Clin Chem. 1999; 45: 1628-50.
    • (1999) Clin Chem , vol.45 , pp. 1628-1650
    • Jayasena, S.D.1
  • 57
    • 77953658260 scopus 로고    scopus 로고
    • The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions
    • Harding FA, Stickler MM, Razo J, et al. The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions. MAbs. 2010; 2: 256-65.
    • (2010) MAbs , vol.2 , pp. 256-265
    • Harding, F.A.1    Stickler, M.M.2    Razo, J.3
  • 59
    • 0034466813 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of an anti-vascular endothelial growth factor aptamer (NX1838) following injection into the vitreous humor of rhesus monkeys
    • Drolet DW, Nelson J, Tucker CE, et al. Pharmacokinetics and safety of an anti-vascular endothelial growth factor aptamer (NX1838) following injection into the vitreous humor of rhesus monkeys. Pharm Res. 2000; 17: 1503-10.
    • (2000) Pharm Res , vol.17 , pp. 1503-1510
    • Drolet, D.W.1    Nelson, J.2    Tucker, C.E.3
  • 60
    • 84872847383 scopus 로고    scopus 로고
    • RNA aptamers targeting cancer stem cell marker CD133
    • Shigdar S, Qiao L, Zhou S-F, et al. RNA aptamers targeting cancer stem cell marker CD133. Cancer Lett. 2013; 330: 84-95.
    • (2013) Cancer Lett , vol.330 , pp. 84-95
    • Shigdar, S.1    Qiao, L.2    Zhou, S.-F.3
  • 61
    • 80052566062 scopus 로고    scopus 로고
    • Clinical applications of aptamers and nucleic acid therapeutics in haematological malignancies
    • Shigdar S, Ward AC, De A, et al. Clinical applications of aptamers and nucleic acid therapeutics in haematological malignancies. Br J Haematol. 2011; 155: 3-13.
    • (2011) Br J Haematol , vol.155 , pp. 3-13
    • Shigdar, S.1    Ward, A.C.2    De, A.3
  • 62
    • 84885364568 scopus 로고    scopus 로고
    • Aptamers as theranostic agents: modifications, serum stability and functionalisation
    • Shigdar S, Macdonald J, O'Connor M, et al. Aptamers as theranostic agents: modifications, serum stability and functionalisation. Sensors (Basel). 2013; 13: 13624-37.
    • (2013) Sensors (Basel) , vol.13 , pp. 13624-13637
    • Shigdar, S.1    Macdonald, J.2    O'Connor, M.3
  • 64
  • 65
    • 51049090204 scopus 로고    scopus 로고
    • Nanoparticle therapeutics: an emerging treatment modality for cancer
    • Davis ME, Chen ZG, Shin DM. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov. 2008; 7: 771-82.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 771-782
    • Davis, M.E.1    Chen, Z.G.2    Shin, D.M.3
  • 66
    • 84876534007 scopus 로고    scopus 로고
    • Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology
    • Prabhakar U, Maeda H, Jain RK, et al. Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology. Cancer Res. 2013; 73: 2412-7.
    • (2013) Cancer Res , vol.73 , pp. 2412-2417
    • Prabhakar, U.1    Maeda, H.2    Jain, R.K.3
  • 67
    • 84902172755 scopus 로고    scopus 로고
    • Ligand-Directed Active Tumor-Targeting Polymeric Nanoparticles for Cancer Chemotherapy
    • Zhong Y, Meng F, Deng C, et al. Ligand-Directed Active Tumor-Targeting Polymeric Nanoparticles for Cancer Chemotherapy. Biomacromolecules. 2014.
    • (2014) Biomacromolecules
    • Zhong, Y.1    Meng, F.2    Deng, C.3
  • 68
    • 84883492467 scopus 로고    scopus 로고
    • Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: lessons learned of the EPR effect and image-guided drug delivery
    • Hollis CP, Weiss HL, Leggas M, et al. Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: lessons learned of the EPR effect and image-guided drug delivery. J Control Release. 2013; 172: 12-21.
    • (2013) J Control Release , vol.172 , pp. 12-21
    • Hollis, C.P.1    Weiss, H.L.2    Leggas, M.3
  • 69
    • 77955175216 scopus 로고    scopus 로고
    • Strategies in the design of nanoparticles for therapeutic applications
    • Petros RA, DeSimone JM. Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov. 2010; 9: 615-27.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 615-627
    • Petros, R.A.1    DeSimone, J.M.2
  • 70
    • 84896699451 scopus 로고    scopus 로고
    • Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology
    • Bertrand N, Wu J, Xu X, et al. Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. Adv Drug Deliv Rev. 2014; 66: 2-25.
    • (2014) Adv Drug Deliv Rev , vol.66 , pp. 2-25
    • Bertrand, N.1    Wu, J.2    Xu, X.3
  • 71
    • 0036781811 scopus 로고    scopus 로고
    • Ligand-targeted therapeutics in anticancer therapy
    • Allen TM. Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer. 2002; 2: 750-63.
    • (2002) Nat Rev Cancer , vol.2 , pp. 750-763
    • Allen, T.M.1
  • 72
    • 84894948077 scopus 로고    scopus 로고
    • Heteromultivalent ligand-decoration for actively targeted nanomedicine
    • Modery-Pawlowski CL, Gupta AS. Heteromultivalent ligand-decoration for actively targeted nanomedicine. Biomaterials. 2014; 35: 2568-79.
    • (2014) Biomaterials , vol.35 , pp. 2568-2579
    • Modery-Pawlowski, C.L.1    Gupta, A.S.2
  • 74
    • 78649315943 scopus 로고    scopus 로고
    • To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery
    • Danhier F, Feron O, Preat V. To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J Control Release. 2010; 148: 135-46.
    • (2010) J Control Release , vol.148 , pp. 135-146
    • Danhier, F.1    Feron, O.2    Preat, V.3
  • 75
    • 84855952224 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule expression (CD326) in cancer: a short review
    • Patriarca C, Macchi RM, Marschner AK, et al. Epithelial cell adhesion molecule expression (CD326) in cancer: a short review. Cancer Treat Rev. 2012; 38: 68-75.
    • (2012) Cancer Treat Rev , vol.38 , pp. 68-75
    • Patriarca, C.1    Macchi, R.M.2    Marschner, A.K.3
  • 77
    • 84898066972 scopus 로고    scopus 로고
    • Antibody-drug conjugates: an emerging concept in cancer therapy
    • Chari RVJ, Miller ML, Widdison WC. Antibody-drug conjugates: an emerging concept in cancer therapy. Angew Chem Int Ed Engl. 2014; 53: 3796-827.
    • (2014) Angew Chem Int Ed Engl , vol.53 , pp. 3796-3827
    • Chari, R.V.J.1    Miller, M.L.2    Widdison, W.C.3
  • 79
    • 70249110439 scopus 로고    scopus 로고
    • Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
    • Dassie JP, Liu XY, Thomas GS, et al. Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nat Biotechnol. 2009; 27: 839-49.
    • (2009) Nat Biotechnol , vol.27 , pp. 839-849
    • Dassie, J.P.1    Liu, X.Y.2    Thomas, G.S.3
  • 80
    • 84887991088 scopus 로고    scopus 로고
    • Aptamers: molecules of great potential
    • Radom F, Jurek PM, Mazurek MP, et al. Aptamers: molecules of great potential. Biotechnol Adv. 2013; 31: 1260-74.
    • (2013) Biotechnol Adv , vol.31 , pp. 1260-1274
    • Radom, F.1    Jurek, P.M.2    Mazurek, M.P.3
  • 81
    • 84892615120 scopus 로고    scopus 로고
    • Site-specific antibody drug conjugates for cancer therapy
    • Panowksi S, Bhakta S, Raab H, et al. Site-specific antibody drug conjugates for cancer therapy. MAbs. 2014; 6: 34-45.
    • (2014) MAbs , vol.6 , pp. 34-45
    • Panowksi, S.1    Bhakta, S.2    Raab, H.3
  • 82
    • 84896993887 scopus 로고    scopus 로고
    • DNA-aptamer targeting vimentin for tumor therapy in vivo
    • Zamay TN, Kolovskaya OS, Glazyrin YE, et al. DNA-aptamer targeting vimentin for tumor therapy in vivo. Nucleic Acid Ther. 2014; 24: 160-70.
    • (2014) Nucleic Acid Ther , vol.24 , pp. 160-170
    • Zamay, T.N.1    Kolovskaya, O.S.2    Glazyrin, Y.E.3
  • 83
    • 1142309575 scopus 로고    scopus 로고
    • Lectins and glycoconjugates in drug delivery and targeting
    • Lehr C-M, Gabor F. Lectins and glycoconjugates in drug delivery and targeting. Adv Drug Deliv Rev. 2004; 56: 419-20.
    • (2004) Adv Drug Deliv Rev , vol.56 , pp. 419-420
    • Lehr, C.-M.1    Gabor, F.2
  • 84
    • 0028791499 scopus 로고
    • Larch arabinogalactan for hepatic drug delivery: isolation and characterization of a 9 kDa arabinogalactan fragment
    • Prescott JH, Enriquez P, Jung C, et al. Larch arabinogalactan for hepatic drug delivery: isolation and characterization of a 9 kDa arabinogalactan fragment. Carbohydr Res. 1995; 278: 113-28.
    • (1995) Carbohydr Res , vol.278 , pp. 113-128
    • Prescott, J.H.1    Enriquez, P.2    Jung, C.3
  • 85
    • 84858202940 scopus 로고    scopus 로고
    • Aptamer-mediated blockade of IL4Ralpha triggers apoptosis of MDSCs and limits tumor progression
    • Roth F, De La Fuente AC, Vella JL, et al. Aptamer-mediated blockade of IL4Ralpha triggers apoptosis of MDSCs and limits tumor progression. Cancer Res. 2012; 72: 1373-83.
    • (2012) Cancer Res , vol.72 , pp. 1373-1383
    • Roth, F.1    De La Fuente, A.C.2    Vella, J.L.3
  • 86
    • 5444225991 scopus 로고    scopus 로고
    • Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
    • Yang L, DeBusk LM, Fukuda K, et al. Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell. 2004; 6: 409-21.
    • (2004) Cancer Cell , vol.6 , pp. 409-421
    • Yang, L.1    DeBusk, L.M.2    Fukuda, K.3
  • 87
    • 0036781709 scopus 로고    scopus 로고
    • MMP9 potentiates pulmonary metastasis formation
    • van Kempen LC, Coussens LM. MMP9 potentiates pulmonary metastasis formation. Cancer Cell. 2002; 2: 251-2.
    • (2002) Cancer Cell , vol.2 , pp. 251-252
    • van Kempen, L.C.1    Coussens, L.M.2
  • 88
    • 77957984394 scopus 로고    scopus 로고
    • Inhibition of Id proteins by a peptide aptamer induces cell-cycle arrest and apoptosis in ovarian cancer cells
    • Mern DS, Hasskarl J, Burwinkel B. Inhibition of Id proteins by a peptide aptamer induces cell-cycle arrest and apoptosis in ovarian cancer cells. Br J Cancer. 2010; 103: 1237-44.
    • (2010) Br J Cancer , vol.103 , pp. 1237-1244
    • Mern, D.S.1    Hasskarl, J.2    Burwinkel, B.3
  • 89
    • 78649324266 scopus 로고    scopus 로고
    • Targeting Id1 and Id3 by a specific peptide aptamer induces E-box promoter activity, cell cycle arrest, and apoptosis in breast cancer cells
    • Mern DS, Hoppe-Seyler K, Hoppe-Seyler F, et al. Targeting Id1 and Id3 by a specific peptide aptamer induces E-box promoter activity, cell cycle arrest, and apoptosis in breast cancer cells. Breast Cancer Res Treat. 2010; 124: 623-33.
    • (2010) Breast Cancer Res Treat , vol.124 , pp. 623-633
    • Mern, D.S.1    Hoppe-Seyler, K.2    Hoppe-Seyler, F.3
  • 90
    • 84555186714 scopus 로고    scopus 로고
    • A novel aptamer developed for breast cancer cell internalization
    • Zhang K, Sefah K, Tang L, et al. A novel aptamer developed for breast cancer cell internalization. ChemMedChem. 2012; 7: 79-84.
    • (2012) ChemMedChem , vol.7 , pp. 79-84
    • Zhang, K.1    Sefah, K.2    Tang, L.3
  • 91
    • 84872442855 scopus 로고    scopus 로고
    • Investigating the antiproliferative activity of high affinity DNA aptamer on cancer cells
    • Kaur H, Li JJ, Bay B-H, et al. Investigating the antiproliferative activity of high affinity DNA aptamer on cancer cells. PLoS One. 2013; 8: e50964.
    • (2013) PLoS One , vol.8
    • Kaur, H.1    Li, J.J.2    Bay, B.-H.3
  • 92
    • 84897388063 scopus 로고    scopus 로고
    • DNA aptamer raised against advanced glycation end products inhibits melanoma growth in nude mice
    • Ojima A, Matsui T, Maeda S, et al. DNA aptamer raised against advanced glycation end products inhibits melanoma growth in nude mice. Lab Invest. 2014; 94: 422-9.
    • (2014) Lab Invest , vol.94 , pp. 422-429
    • Ojima, A.1    Matsui, T.2    Maeda, S.3
  • 93
    • 84862744821 scopus 로고    scopus 로고
    • An RNA aptamer that binds carcinoembryonic antigen inhibits hepatic metastasis of colon cancer cells in mice
    • Lee YJ, Han SR, Kim NY, et al. An RNA aptamer that binds carcinoembryonic antigen inhibits hepatic metastasis of colon cancer cells in mice. Gastroenterology. 2012; 143: 155-65.e8.
    • (2012) Gastroenterology , vol.143 , pp. 155-165
    • Lee, Y.J.1    Han, S.R.2    Kim, N.Y.3
  • 94
    • 55549144337 scopus 로고    scopus 로고
    • Selective photothermal therapy for mixed cancer cells using aptamer-conjugated nanorods
    • Huang Y-F, Sefah K, Bamrungsap S, et al. Selective photothermal therapy for mixed cancer cells using aptamer-conjugated nanorods. Langmuir. 2008; 24: 11860-5.
    • (2008) Langmuir , vol.24 , pp. 11860-11865
    • Huang, Y.-F.1    Sefah, K.2    Bamrungsap, S.3
  • 95
    • 84871711842 scopus 로고    scopus 로고
    • Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems
    • Tacar O, Sriamornsak P, Dass CR. Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems. J Pharm Pharmacol. 2013; 65: 157-70.
    • (2013) J Pharm Pharmacol , vol.65 , pp. 157-170
    • Tacar, O.1    Sriamornsak, P.2    Dass, C.R.3
  • 96
    • 84900371949 scopus 로고    scopus 로고
    • Intercalation of antitumor drug doxorubicin and its analogue by DNA duplex: Structural features and biological implications
    • Agudelo D, Bourassa P, Berube G, et al. Intercalation of antitumor drug doxorubicin and its analogue by DNA duplex: Structural features and biological implications. Int J Biol Macromol. 2014; 66: 144-50.
    • (2014) Int J Biol Macromol , vol.66 , pp. 144-150
    • Agudelo, D.1    Bourassa, P.2    Berube, G.3
  • 97
    • 2642566088 scopus 로고    scopus 로고
    • Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
    • Minotti G, Menna P, Salvatorelli E, et al. Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev. 2004; 56: 185-229.
    • (2004) Pharmacol Rev , vol.56 , pp. 185-229
    • Minotti, G.1    Menna, P.2    Salvatorelli, E.3
  • 98
    • 0033988166 scopus 로고    scopus 로고
    • The structural basis for molecular recognition by the vitamin B 12 RNA aptamer
    • Sussman D, Nix JC, Wilson C. The structural basis for molecular recognition by the vitamin B 12 RNA aptamer. Nat Struct Biol. 2000; 7: 53-7.
    • (2000) Nat Struct Biol , vol.7 , pp. 53-57
    • Sussman, D.1    Nix, J.C.2    Wilson, C.3
  • 99
    • 84862534993 scopus 로고    scopus 로고
    • Self-assembled aptamer-based drug carriers for bispecific cytotoxicity to cancer cells
    • Zhu G, Meng L, Ye M, et al. Self-assembled aptamer-based drug carriers for bispecific cytotoxicity to cancer cells. Chem Asian J. 2012; 7: 1630-6.
    • (2012) Chem Asian J , vol.7 , pp. 1630-1636
    • Zhu, G.1    Meng, L.2    Ye, M.3
  • 100
    • 65549102827 scopus 로고    scopus 로고
    • Molecular assembly of an aptamer-drug conjugate for targeted drug delivery to tumor cells
    • Huang YF, Shangguan D, Liu H, et al. Molecular assembly of an aptamer-drug conjugate for targeted drug delivery to tumor cells. Chembiochem. 2009; 10: 862-8.
    • (2009) Chembiochem , vol.10 , pp. 862-868
    • Huang, Y.F.1    Shangguan, D.2    Liu, H.3
  • 101
    • 84863145260 scopus 로고    scopus 로고
    • Novel MUC1 aptamer selectively delivers cytotoxic agent to cancer cells in vitro
    • Hu Y, Duan J, Zhan Q, et al. Novel MUC1 aptamer selectively delivers cytotoxic agent to cancer cells in vitro. PLoS One. 2012; 7: e31970.
    • (2012) PLoS One , vol.7
    • Hu, Y.1    Duan, J.2    Zhan, Q.3
  • 102
    • 84867754001 scopus 로고    scopus 로고
    • Novel HER2 aptamer selectively delivers cytotoxic drug to HER2-positive breast cancer cells in vitro
    • Liu Z, Duan JH, Song YM, et al. Novel HER2 aptamer selectively delivers cytotoxic drug to HER2-positive breast cancer cells in vitro. J Transl Med. 2012; 10: 148.
    • (2012) J Transl Med , vol.10 , pp. 148
    • Liu, Z.1    Duan, J.H.2    Song, Y.M.3
  • 103
    • 84870448531 scopus 로고    scopus 로고
    • Target-specific delivery of doxorubicin to retinoblastoma using epithelial cell adhesion molecule aptamer
    • Subramanian N, Raghunathan V, Kanwar JR, et al. Target-specific delivery of doxorubicin to retinoblastoma using epithelial cell adhesion molecule aptamer. Mol Vis. 2012; 18: 2783-95.
    • (2012) Mol Vis , vol.18 , pp. 2783-2795
    • Subramanian, N.1    Raghunathan, V.2    Kanwar, J.R.3
  • 104
    • 84870357347 scopus 로고    scopus 로고
    • Aptamer-mediated delivery of chemotherapy to pancreatic cancer cells
    • Ray P, Cheek MA, Sharaf ML, et al. Aptamer-mediated delivery of chemotherapy to pancreatic cancer cells. Nucleic Acid Ther. 2012; 22: 295-305.
    • (2012) Nucleic Acid Ther , vol.22 , pp. 295-305
    • Ray, P.1    Cheek, M.A.2    Sharaf, M.L.3
  • 105
    • 79251517121 scopus 로고    scopus 로고
    • Block copolymer based composition and morphology control in nanostructured hybrid materials for energy conversion and storage: solar cells, batteries, and fuel cells
    • Orilall MC, Wiesner U. Block copolymer based composition and morphology control in nanostructured hybrid materials for energy conversion and storage: solar cells, batteries, and fuel cells. Chem Soc Rev. 2011; 40: 520-35.
    • (2011) Chem Soc Rev , vol.40 , pp. 520-535
    • Orilall, M.C.1    Wiesner, U.2
  • 106
    • 42349106952 scopus 로고    scopus 로고
    • Co-delivery of hydrophobic and hydrophilic drugs from nanoparticle-aptamer bioconjugates
    • Zhang L, Radovic-Moreno AF, Alexis F, et al. Co-delivery of hydrophobic and hydrophilic drugs from nanoparticle-aptamer bioconjugates. ChemMedChem. 2007; 2: 1268-71.
    • (2007) ChemMedChem , vol.2 , pp. 1268-1271
    • Zhang, L.1    Radovic-Moreno, A.F.2    Alexis, F.3
  • 107
    • 56249097260 scopus 로고    scopus 로고
    • Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles
    • Dhar S, Gu FX, Langer R, et al. Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Proc Natl Acad Sci U S A. 2008; 105: 17356-61.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 17356-17361
    • Dhar, S.1    Gu, F.X.2    Langer, R.3
  • 108
    • 84864708256 scopus 로고    scopus 로고
    • Aptamer-functionalized nanoparticles for medical applications: challenges and opportunities
    • Xiao Z, Farokhzad OC. Aptamer-functionalized nanoparticles for medical applications: challenges and opportunities. ACS Nano. 2012; 6: 3670-6.
    • (2012) ACS Nano , vol.6 , pp. 3670-3676
    • Xiao, Z.1    Farokhzad, O.C.2
  • 109
  • 110
    • 58249086971 scopus 로고    scopus 로고
    • PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery
    • Chan JM, Zhang L, Yuet KP, et al. PLGA-lecithin-PEG core-shell nanoparticles for controlled drug delivery. Biomaterials. 2009; 30: 1627-34.
    • (2009) Biomaterials , vol.30 , pp. 1627-1634
    • Chan, J.M.1    Zhang, L.2    Yuet, K.P.3
  • 111
    • 77951498427 scopus 로고    scopus 로고
    • Transferrin-conjugated lipid-coated PLGA nanoparticles for targeted delivery of aromatase inhibitor 7alpha-APTADD to breast cancer cells
    • Zheng Y, Yu B, Weecharangsan W, et al. Transferrin-conjugated lipid-coated PLGA nanoparticles for targeted delivery of aromatase inhibitor 7alpha-APTADD to breast cancer cells. Int J Pharm. 2010; 390: 234-41.
    • (2010) Int J Pharm , vol.390 , pp. 234-241
    • Zheng, Y.1    Yu, B.2    Weecharangsan, W.3
  • 112
    • 7444223607 scopus 로고    scopus 로고
    • Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells
    • Farokhzad OC, Jon S, Khademhosseini A, et al. Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells. Cancer Res. 2004; 64: 7668-72.
    • (2004) Cancer Res , vol.64 , pp. 7668-7672
    • Farokhzad, O.C.1    Jon, S.2    Khademhosseini, A.3
  • 113
    • 33646582037 scopus 로고    scopus 로고
    • Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
    • Farokhzad OC, Cheng J, Teply BA, et al. Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc Natl Acad Sci U S A. 2006; 103: 6315-20.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 6315-6320
    • Farokhzad, O.C.1    Cheng, J.2    Teply, B.A.3
  • 114
    • 0031447927 scopus 로고    scopus 로고
    • Comparative antitumor efficacy of docetaxel and paclitaxel in nude mice bearing human tumor xenografts that overexpress the multidrug resistance protein (MRP)
    • Vanhoefer U, Cao S, Harstrick A, et al. Comparative antitumor efficacy of docetaxel and paclitaxel in nude mice bearing human tumor xenografts that overexpress the multidrug resistance protein (MRP). Ann Oncol. 1997; 8: 1221-8.
    • (1997) Ann Oncol , vol.8 , pp. 1221-1228
    • Vanhoefer, U.1    Cao, S.2    Harstrick, A.3
  • 115
    • 67349167635 scopus 로고    scopus 로고
    • Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer
    • Bates PJ, Laber DA, Miller DM, et al. Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer. Exp Mol Pathol. 2009; 86: 151-64.
    • (2009) Exp Mol Pathol , vol.86 , pp. 151-164
    • Bates, P.J.1    Laber, D.A.2    Miller, D.M.3
  • 116
    • 80051817418 scopus 로고    scopus 로고
    • Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug delivery
    • Guo J, Gao X, Su L, et al. Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug delivery. Biomaterials. 2011; 32: 8010-20.
    • (2011) Biomaterials , vol.32 , pp. 8010-8020
    • Guo, J.1    Gao, X.2    Su, L.3
  • 117
    • 84890727853 scopus 로고    scopus 로고
    • Targeted thermosensitive liposomes: an attractive novel approach for increased drug delivery to solid tumors
    • Dicheva BM, Koning GA. Targeted thermosensitive liposomes: an attractive novel approach for increased drug delivery to solid tumors. Expert Opin Drug Deliv. 2014; 11: 83-100.
    • (2014) Expert Opin Drug Deliv , vol.11 , pp. 83-100
    • Dicheva, B.M.1    Koning, G.A.2
  • 118
    • 84893204137 scopus 로고    scopus 로고
    • Current trends in the use of liposomes for tumor targeting
    • Deshpande PP, Biswas S, Torchilin VP. Current trends in the use of liposomes for tumor targeting. Nanomedicine (Lond). 2013; 8: 1509-28.
    • (2013) Nanomedicine (Lond) , vol.8 , pp. 1509-1528
    • Deshpande, P.P.1    Biswas, S.2    Torchilin, V.P.3
  • 119
    • 34248638766 scopus 로고    scopus 로고
    • Enhanced solubility and stability of PEGylated liposomal paclitaxel: in vitro and in vivo evaluation
    • Yang T, Cui F-D, Choi M-K, et al. Enhanced solubility and stability of PEGylated liposomal paclitaxel: in vitro and in vivo evaluation. Int J Pharm. 2007; 338: 317-26.
    • (2007) Int J Pharm , vol.338 , pp. 317-326
    • Yang, T.1    Cui, F.-D.2    Choi, M.-K.3
  • 120
    • 70349577793 scopus 로고    scopus 로고
    • The encapsulation and release of guanosine from PEGylated liposomes
    • Er Y, Barnes TJ, Fornasiero D, et al. The encapsulation and release of guanosine from PEGylated liposomes. J Liposome Res. 2009; 19: 29-36.
    • (2009) J Liposome Res , vol.19 , pp. 29-36
    • Er, Y.1    Barnes, T.J.2    Fornasiero, D.3
  • 121
    • 70350292588 scopus 로고    scopus 로고
    • Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer
    • Malam Y, Loizidou M, Seifalian AM. Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer. Trends Pharmacol Sci. 2009; 30: 592-9.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 592-599
    • Malam, Y.1    Loizidou, M.2    Seifalian, A.M.3
  • 122
    • 75649089648 scopus 로고    scopus 로고
    • A liposome-based nanostructure for aptamer directed delivery
    • Kang H, O'Donoghue MB, Liu H, et al. A liposome-based nanostructure for aptamer directed delivery. Chem Commun (Camb). 2010; 46: 249-51.
    • (2010) Chem Commun (Camb) , vol.46 , pp. 249-251
    • Kang, H.1    O'Donoghue, M.B.2    Liu, H.3
  • 123
    • 84884397713 scopus 로고    scopus 로고
    • Selective Delivery of an Anticancer Drug with Aptamer-Functionalized Liposomes to Breast Cancer Cells and in vitro and in vivo
    • Xing H, Tang L, Yang X, et al. Selective Delivery of an Anticancer Drug with Aptamer-Functionalized Liposomes to Breast Cancer Cells and in vitro and in vivo. J Mater Chem B Mater Biol Med. 2013; 1: 5288-97.
    • (2013) J Mater Chem B Mater Biol Med , vol.1 , pp. 5288-5297
    • Xing, H.1    Tang, L.2    Yang, X.3
  • 124
    • 0034753215 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging
    • Wang YX, Hussain SM, Krestin GP. Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging. Eur Radiol. 2001; 11: 2319-31.
    • (2001) Eur Radiol , vol.11 , pp. 2319-2331
    • Wang, Y.X.1    Hussain, S.M.2    Krestin, G.P.3
  • 125
    • 33745915834 scopus 로고    scopus 로고
    • Preclinical safety and pharmacokinetic profile of ferumoxtran-10, an ultrasmall superparamagnetic iron oxide magnetic resonance contrast agent
    • Bourrinet P, Bengele HH, Bonnemain B, et al. Preclinical safety and pharmacokinetic profile of ferumoxtran-10, an ultrasmall superparamagnetic iron oxide magnetic resonance contrast agent. Invest Radiol. 2006; 41: 313-24.
    • (2006) Invest Radiol , vol.41 , pp. 313-324
    • Bourrinet, P.1    Bengele, H.H.2    Bonnemain, B.3
  • 126
    • 54849404705 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy
    • Wang AZ, Bagalkot V, Vasilliou CC, et al. Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy. ChemMedChem. 2008; 3: 1311-5.
    • (2008) ChemMedChem , vol.3 , pp. 1311-1315
    • Wang, A.Z.1    Bagalkot, V.2    Vasilliou, C.C.3
  • 127
    • 84881151187 scopus 로고    scopus 로고
    • Epirubicin loaded super paramagnetic iron oxide nanoparticle-aptamer bioconjugate for combined colon cancer therapy and imaging in vivo
    • Jalalian SH, Taghdisi SM, Shahidi Hamedani N, et al. Epirubicin loaded super paramagnetic iron oxide nanoparticle-aptamer bioconjugate for combined colon cancer therapy and imaging in vivo. Eur J Pharm Sci. 2013; 50: 191-7.
    • (2013) Eur J Pharm Sci , vol.50 , pp. 191-197
    • Jalalian, S.H.1    Taghdisi, S.M.2    Shahidi Hamedani, N.3
  • 128
    • 83555177197 scopus 로고    scopus 로고
    • Single walled carbon nanotubes as drug delivery vehicles: targeting doxorubicin to tumors
    • Meng L, Zhang X, Lu Q, et al. Single walled carbon nanotubes as drug delivery vehicles: targeting doxorubicin to tumors. Biomaterials. 2012; 33: 1689-98.
    • (2012) Biomaterials , vol.33 , pp. 1689-1698
    • Meng, L.1    Zhang, X.2    Lu, Q.3
  • 129
    • 45849090317 scopus 로고    scopus 로고
    • Recent developments in nanoparticle-based drug delivery and targeting systems with emphasis on protein-based nanoparticles
    • Wang G, Uludag H. Recent developments in nanoparticle-based drug delivery and targeting systems with emphasis on protein-based nanoparticles. Expert Opin Drug Deliv. 2008; 5: 499-515.
    • (2008) Expert Opin Drug Deliv , vol.5 , pp. 499-515
    • Wang, G.1    Uludag, H.2
  • 130
    • 80054681184 scopus 로고    scopus 로고
    • Targeted chemoimmunotherapy using drug-loaded aptamer-dendrimer bioconjugates
    • Lee IH, An S, Yu MK, et al. Targeted chemoimmunotherapy using drug-loaded aptamer-dendrimer bioconjugates. J Control Release. 2011; 155: 435-41.
    • (2011) J Control Release , vol.155 , pp. 435-441
    • Lee, I.H.1    An, S.2    Yu, M.K.3
  • 131
    • 84870949287 scopus 로고    scopus 로고
    • Aptamer-capped multifunctional mesoporous strontium hydroxyapatite nanovehicle for cancer-cell-responsive drug delivery and imaging
    • Li Z, Liu Z, Yin M, et al. Aptamer-capped multifunctional mesoporous strontium hydroxyapatite nanovehicle for cancer-cell-responsive drug delivery and imaging. Biomacromolecules. 2012; 13: 4257-63.
    • (2012) Biomacromolecules , vol.13 , pp. 4257-4263
    • Li, Z.1    Liu, Z.2    Yin, M.3
  • 132
    • 84878538160 scopus 로고    scopus 로고
    • Aptamer-based nanoparticles for cancer targeting
    • Sa LTM, Simmons S, Missailidis S, et al. Aptamer-based nanoparticles for cancer targeting. J Drug Target. 2013; 21: 427-34.
    • (2013) J Drug Target , vol.21 , pp. 427-434
    • Sa, L.T.M.1    Simmons, S.2    Missailidis, S.3
  • 133
    • 84856153806 scopus 로고    scopus 로고
    • Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection
    • Xiao Z, Levy-Nissenbaum E, Alexis F, et al. Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection. ACS Nano. 2012; 6: 696-704.
    • (2012) ACS Nano , vol.6 , pp. 696-704
    • Xiao, Z.1    Levy-Nissenbaum, E.2    Alexis, F.3
  • 134
    • 84911869868 scopus 로고    scopus 로고
    • Efficient delivery of micro RNA to bone-metastatic prostate tumors by using aptamer-conjugated atelocollagen in vitro and in vivo
    • Hao Z, Fan W, Hao J, et al. Efficient delivery of micro RNA to bone-metastatic prostate tumors by using aptamer-conjugated atelocollagen in vitro and in vivo. Drug Deliv. 2014: 1-8.
    • (2014) Drug Deliv , pp. 1-8
    • Hao, Z.1    Fan, W.2    Hao, J.3
  • 135
    • 84866759245 scopus 로고    scopus 로고
    • AS1411 aptamer tagged PLGA-lecithin-PEG nanoparticles for tumor cell targeting and drug delivery
    • Aravind A, Jeyamohan P, Nair R, et al. AS1411 aptamer tagged PLGA-lecithin-PEG nanoparticles for tumor cell targeting and drug delivery. Biotechnol Bioeng. 2012; 109: 2920-31.
    • (2012) Biotechnol Bioeng , vol.109 , pp. 2920-2931
    • Aravind, A.1    Jeyamohan, P.2    Nair, R.3
  • 136
    • 84885106615 scopus 로고    scopus 로고
    • Aptamer conjugated paclitaxel and magnetic fluid loaded fluorescently tagged PLGA nanoparticles for targeted cancer therapy
    • Aravind A, Nair R, Raveendran S, et al. Aptamer conjugated paclitaxel and magnetic fluid loaded fluorescently tagged PLGA nanoparticles for targeted cancer therapy. J Magn Magn Mater. 2013; 344: 116-23.
    • (2013) J Magn Magn Mater , vol.344 , pp. 116-123
    • Aravind, A.1    Nair, R.2    Raveendran, S.3
  • 137
    • 84886915604 scopus 로고    scopus 로고
    • Aptamer conjugated theragnostic multifunctional magnetic nanoparticles as a nanoplatform for pancreatic cancer therapy
    • Sivakumar B, Aswathy RG, Nagaoka Y, et al. Aptamer conjugated theragnostic multifunctional magnetic nanoparticles as a nanoplatform for pancreatic cancer therapy. RSC Adv. 2013; 3: 20579-98.
    • (2013) RSC Adv , vol.3 , pp. 20579-20598
    • Sivakumar, B.1    Aswathy, R.G.2    Nagaoka, Y.3
  • 138
    • 84905593520 scopus 로고    scopus 로고
    • Cytochrome c end-capped mesoporous silica nanoparticles as redox-responsive drug delivery vehicles for liver tumor-targeted triplex therapy in vitro and in vivo
    • Zhang B, Luo Z, Liu J, et al. Cytochrome c end-capped mesoporous silica nanoparticles as redox-responsive drug delivery vehicles for liver tumor-targeted triplex therapy in vitro and in vivo. J Control Release. 2014; 192C: 192-201.
    • (2014) J Control Release , vol.192 C , pp. 192-201
    • Zhang, B.1    Luo, Z.2    Liu, J.3
  • 139
    • 84903733502 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of antitumor drug -loaded aptamer targeted single-walled carbon nanotubes system
    • [Epub ahead of print]
    • Zhang H, Hou L, Jiao X, et al. In vitro and in vivo evaluation of antitumor drug -loaded aptamer targeted single-walled carbon nanotubes system. Curr Pharm Biotechnol. 2014; doi: 10.2174/1389201015666140408123710. [Epub ahead of print].
    • (2014) Curr Pharm Biotechnol
    • Zhang, H.1    Hou, L.2    Jiao, X.3
  • 140
    • 84861809558 scopus 로고    scopus 로고
    • Near-infrared light-triggered, targeted drug delivery to cancer cells by aptamer gated nanovehicles
    • Yang X, Liu X, Liu Z, et al. Near-infrared light-triggered, targeted drug delivery to cancer cells by aptamer gated nanovehicles. Adv Mater. 2012; 24: 2890-5.
    • (2012) Adv Mater , vol.24 , pp. 2890-2895
    • Yang, X.1    Liu, X.2    Liu, Z.3
  • 141
    • 84919946897 scopus 로고    scopus 로고
    • Aptamer-Functionalized Gold Nanoparticles As Photoresponsive Nanoplatform for Co-Drug Delivery
    • [Epub ahead of print]
    • Shiao YS, Chiu HH, Wu PH, et al. Aptamer-Functionalized Gold Nanoparticles As Photoresponsive Nanoplatform for Co-Drug Delivery. ACS Appl Mater Interfaces. 2014: doi:10.1021/am5026243. [Epub ahead of print].
    • ACS Appl Mater Interfaces , vol.2014
    • Shiao, Y.S.1    Chiu, H.H.2    Wu, P.H.3
  • 142
    • 80052349603 scopus 로고    scopus 로고
    • Novel aptamer-nanoparticle bioconjugates enhances delivery of anticancer drug to MUC1-positive cancer cells in vitro
    • Yu C, Hu Y, Duan J, et al. Novel aptamer-nanoparticle bioconjugates enhances delivery of anticancer drug to MUC1-positive cancer cells in vitro. PLoS One. 2011; 6: e24077.
    • (2011) PLoS One , vol.6
    • Yu, C.1    Hu, Y.2    Duan, J.3
  • 143
    • 84890450890 scopus 로고    scopus 로고
    • Building a multifunctional aptamer-based DNA nanoassembly for targeted cancer therapy
    • Wu C, Han D, Chen T, et al. Building a multifunctional aptamer-based DNA nanoassembly for targeted cancer therapy. J Am Chem Soc. 2013; 135: 18644-50.
    • (2013) J Am Chem Soc , vol.135 , pp. 18644-18650
    • Wu, C.1    Han, D.2    Chen, T.3
  • 144
    • 84877858909 scopus 로고    scopus 로고
    • Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics
    • Zhu G, Zheng J, Song E, et al. Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics. Proc Natl Acad Sci U S A. 2013; 110: 7998-8003.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 7998-8003
    • Zhu, G.1    Zheng, J.2    Song, E.3
  • 145
    • 70349326658 scopus 로고    scopus 로고
    • Recognition of subtype non-small cell lung cancer by DNA aptamers selected from living cells
    • Zhao Z, Xu L, Shi X, et al. Recognition of subtype non-small cell lung cancer by DNA aptamers selected from living cells. Analyst. 2009; 134: 1808-14.
    • (2009) Analyst , vol.134 , pp. 1808-1814
    • Zhao, Z.1    Xu, L.2    Shi, X.3
  • 146
    • 79954481313 scopus 로고    scopus 로고
    • Intracellular delivery of RNA-based therapeutics using aptamers
    • Thiel KW, Giangrande PH. Intracellular delivery of RNA-based therapeutics using aptamers. Ther Deliv. 2010; 1: 849-61.
    • (2010) Ther Deliv , vol.1 , pp. 849-861
    • Thiel, K.W.1    Giangrande, P.H.2
  • 147
    • 80455174398 scopus 로고    scopus 로고
    • Coupling Aptamers to Short Interfering RNAs as Therapeutics
    • Cerchia L, Esposito CL, Camorani S, et al. Coupling Aptamers to Short Interfering RNAs as Therapeutics. Pharmaceuticals. 2011; 4: 1434-49.
    • (2011) Pharmaceuticals , vol.4 , pp. 1434-1449
    • Cerchia, L.1    Esposito, C.L.2    Camorani, S.3
  • 148
    • 79957920185 scopus 로고    scopus 로고
    • Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts
    • Ni X, Zhang Y, Ribas J, et al. Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts. J Clin Invest. 2011; 121: 2383-90.
    • (2011) J Clin Invest , vol.121 , pp. 2383-2390
    • Ni, X.1    Zhang, Y.2    Ribas, J.3
  • 149
    • 33745714275 scopus 로고    scopus 로고
    • Aptamer:toxin conjugates that specifically target prostate tumor cells
    • Chu TC, Marks JW, 3rd, Lavery LA, et al. Aptamer:toxin conjugates that specifically target prostate tumor cells. Cancer Res. 2006; 66: 5989-92.
    • (2006) Cancer Res , vol.66 , pp. 5989-5992
    • Chu, T.C.1    Marks, J.W.2    Lavery, L.A.3
  • 150
    • 33747031960 scopus 로고    scopus 로고
    • Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras
    • McNamara JO, 2nd, Andrechek ER, Wang Y, et al. Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras. Nat Biotechnol. 2006; 24: 1005-15.
    • (2006) Nat Biotechnol , vol.24 , pp. 1005-1015
    • McNamara, J.O.1    Andrechek, E.R.2    Wang, Y.3
  • 151
    • 33751099034 scopus 로고    scopus 로고
    • RNAi therapeutics: a potential new class of pharmaceutical drugs
    • Bumcrot D, Manoharan M, Koteliansky V, et al. RNAi therapeutics: a potential new class of pharmaceutical drugs. Nat Chem Biol. 2006; 2: 711-9.
    • (2006) Nat Chem Biol , vol.2 , pp. 711-719
    • Bumcrot, D.1    Manoharan, M.2    Koteliansky, V.3
  • 152
    • 84875171615 scopus 로고    scopus 로고
    • Current progress of RNA aptamer-based therapeutics
    • Zhou J, Bobbin ML, Burnett JC, et al. Current progress of RNA aptamer-based therapeutics. Front Genet. 2012; 3: 234.
    • (2012) Front Genet , vol.3 , pp. 234
    • Zhou, J.1    Bobbin, M.L.2    Burnett, J.C.3
  • 153
    • 84892941233 scopus 로고    scopus 로고
    • Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity
    • Berezhnoy A, Castro I, Levay A, et al. Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity. J Clin Invest. 2014; 124: 188-97.
    • (2014) J Clin Invest , vol.124 , pp. 188-197
    • Berezhnoy, A.1    Castro, I.2    Levay, A.3
  • 154
    • 84894952867 scopus 로고    scopus 로고
    • Synergistic inhibition of lung cancer cell invasion, tumor growth and angiogenesis using aptamer-siRNA chimeras
    • Lai W-Y, Wang W-Y, Chang Y-C, et al. Synergistic inhibition of lung cancer cell invasion, tumor growth and angiogenesis using aptamer-siRNA chimeras. Biomaterials. 2014; 35: 2905-14.
    • (2014) Biomaterials , vol.35 , pp. 2905-2914
    • Lai, W.-Y.1    Wang, W.-Y.2    Chang, Y.-C.3
  • 155
    • 73349125465 scopus 로고    scopus 로고
    • MicroRNAs in cancer: small molecules with a huge impact
    • Iorio MV, Croce CM. MicroRNAs in cancer: small molecules with a huge impact. J Clin Oncol. 2009; 27: 5848-56.
    • (2009) J Clin Oncol , vol.27 , pp. 5848-5856
    • Iorio, M.V.1    Croce, C.M.2
  • 156
    • 24644446398 scopus 로고    scopus 로고
    • Ribo-gnome: the big world of small RNAs
    • Zamore PD, Haley B. Ribo-gnome: the big world of small RNAs. Science. 2005; 309: 1519-24.
    • (2005) Science , vol.309 , pp. 1519-1524
    • Zamore, P.D.1    Haley, B.2
  • 157
    • 84858126071 scopus 로고    scopus 로고
    • MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics A comprehensive review
    • Iorio MV, Croce CM. MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med. 2012; 4: 143-59.
    • (2012) EMBO Mol Med , vol.4 , pp. 143-159
    • Iorio, M.V.1    Croce, C.M.2
  • 158
    • 74249112785 scopus 로고    scopus 로고
    • MicroRNAs as regulators of death receptors signaling
    • Garofalo M, Condorelli GL, Croce CM, et al. MicroRNAs as regulators of death receptors signaling. Cell Death Differ. 2010; 17: 200-8.
    • (2010) Cell Death Differ , vol.17 , pp. 200-208
    • Garofalo, M.1    Condorelli, G.L.2    Croce, C.M.3
  • 159
    • 84902144911 scopus 로고    scopus 로고
    • Multifunctional Aptamer-miRNA Conjugates for Targeted Cancer Therapy
    • Esposito CL, Cerchia L, Catuogno S, et al. Multifunctional Aptamer-miRNA Conjugates for Targeted Cancer Therapy. Mol Ther. 2014; 22: 1151-63.
    • (2014) Mol Ther , vol.22 , pp. 1151-1163
    • Esposito, C.L.1    Cerchia, L.2    Catuogno, S.3
  • 160
    • 0037197914 scopus 로고    scopus 로고
    • RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells
    • Yu J-Y, DeRuiter SL, Turner DL. RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc Natl Acad Sci U S A. 2002; 99: 6047-52.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 6047-6052
    • Yu, J.-Y.1    DeRuiter, S.L.2    Turner, D.L.3
  • 161
    • 83555173596 scopus 로고    scopus 로고
    • RNA interference and cancer therapy
    • Wang Z, Rao DD, Senzer N, et al. RNA interference and cancer therapy. Pharm Res. 2011; 28: 2983-95.
    • (2011) Pharm Res , vol.28 , pp. 2983-2995
    • Wang, Z.1    Rao, D.D.2    Senzer, N.3
  • 162
    • 65749088084 scopus 로고    scopus 로고
    • siRNA vs. shRNA: similarities and differences
    • Rao DD, Vorhies JS, Senzer N, et al. siRNA vs. shRNA: similarities and differences. Adv Drug Deliv Rev. 2009; 61: 746-59.
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 746-759
    • Rao, D.D.1    Vorhies, J.S.2    Senzer, N.3
  • 163
    • 0015462030 scopus 로고
    • Combination cancer therapy: Presidential address
    • Frei E, 3rd. Combination cancer therapy: Presidential address. Cancer Res. 1972; 32: 2593-607.
    • (1972) Cancer Res , vol.32 , pp. 2593-2607
    • Frei, E.1
  • 164
    • 0034680167 scopus 로고    scopus 로고
    • Molecular mechanisms that confer antibacterial drug resistance
    • Walsh C. Molecular mechanisms that confer antibacterial drug resistance. Nature. 2000; 406: 775-81.
    • (2000) Nature , vol.406 , pp. 775-781
    • Walsh, C.1
  • 165
    • 56049117207 scopus 로고    scopus 로고
    • Combination chemotherapy and photodynamic therapy with fab' fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells
    • Hongrapipat J, Kopeckova P, Liu J, et al. Combination chemotherapy and photodynamic therapy with fab' fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells. Mol Pharm. 2008; 5: 696-709.
    • (2008) Mol Pharm , vol.5 , pp. 696-709
    • Hongrapipat, J.1    Kopeckova, P.2    Liu, J.3
  • 166
    • 64249107600 scopus 로고    scopus 로고
    • Self-assembled oligopeptide nanostructures for co-delivery of drug and gene with synergistic therapeutic effect
    • Wiradharma N, Tong YW, Yang Y-Y. Self-assembled oligopeptide nanostructures for co-delivery of drug and gene with synergistic therapeutic effect. Biomaterials. 2009; 30: 3100-9.
    • (2009) Biomaterials , vol.30 , pp. 3100-3109
    • Wiradharma, N.1    Tong, Y.W.2    Yang, Y.-Y.3
  • 167
    • 58849095012 scopus 로고    scopus 로고
    • Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells
    • Yadav S, van Vlerken LE, Little SR, et al. Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells. Cancer Chemother Pharmacol. 2009; 63: 711-22.
    • (2009) Cancer Chemother Pharmacol , vol.63 , pp. 711-722
    • Yadav, S.1    van Vlerken, L.E.2    Little, S.R.3
  • 168
    • 84866883611 scopus 로고    scopus 로고
    • Reversal of paclitaxel resistance in epithelial ovarian carcinoma cells by a MUC1 aptamer-let-7i chimera
    • Liu N, Zhou C, Zhao J, et al. Reversal of paclitaxel resistance in epithelial ovarian carcinoma cells by a MUC1 aptamer-let-7i chimera. Cancer Invest. 2012; 30: 577-82.
    • (2012) Cancer Invest , vol.30 , pp. 577-582
    • Liu, N.1    Zhou, C.2    Zhao, J.3
  • 169
    • 77950051368 scopus 로고    scopus 로고
    • Prostate cancer cell death produced by the co-delivery of Bcl-xL shRNA and doxorubicin using an aptamer-conjugated polyplex
    • Kim E, Jung Y, Choi H, et al. Prostate cancer cell death produced by the co-delivery of Bcl-xL shRNA and doxorubicin using an aptamer-conjugated polyplex. Biomaterials. 2010; 31: 4592-9.
    • (2010) Biomaterials , vol.31 , pp. 4592-4599
    • Kim, E.1    Jung, Y.2    Choi, H.3
  • 170
    • 84899491559 scopus 로고    scopus 로고
    • Current progress of aptamer-based molecular imaging
    • Wang AZ, Farokhzad OC. Current progress of aptamer-based molecular imaging. J Nucl Med. 2014; 55: 353-6.
    • (2014) J Nucl Med , vol.55 , pp. 353-356
    • Wang, A.Z.1    Farokhzad, O.C.2
  • 171
    • 79960908735 scopus 로고    scopus 로고
    • Role of loop entropy in the force induced melting of DNA hairpin
    • Mishra G, Giri D, Li MS, et al. Role of loop entropy in the force induced melting of DNA hairpin. J Chem Phys. 2011; 135: 035102.
    • (2011) J Chem Phys , vol.135
    • Mishra, G.1    Giri, D.2    Li, M.S.3
  • 172
    • 5444274479 scopus 로고    scopus 로고
    • Functionalized nanoparticles for liquid atmospheric pressure matrix-assisted laser desorption/ionization peptide analysis
    • Turney K, Drake TJ, Smith JE, et al. Functionalized nanoparticles for liquid atmospheric pressure matrix-assisted laser desorption/ionization peptide analysis. Rapid Commun Mass Spectrom. 2004; 18: 2367-74.
    • (2004) Rapid Commun Mass Spectrom , vol.18 , pp. 2367-2374
    • Turney, K.1    Drake, T.J.2    Smith, J.E.3
  • 173
    • 0141572106 scopus 로고    scopus 로고
    • Synthetic DNA aptamers to detect protein molecular variants in a high-throughput fluorescence quenching assay
    • Fang X, Sen A, Vicens M, et al. Synthetic DNA aptamers to detect protein molecular variants in a high-throughput fluorescence quenching assay. Chembiochem. 2003; 4: 829-34.
    • (2003) Chembiochem , vol.4 , pp. 829-834
    • Fang, X.1    Sen, A.2    Vicens, M.3
  • 174
    • 0346243925 scopus 로고    scopus 로고
    • Medicine: taking apart a cancer protein
    • Scaglioni PP, Pandolfi PP. Medicine: taking apart a cancer protein. Nature. 2003; 426: 512-3.
    • (2003) Nature , vol.426 , pp. 512-513
    • Scaglioni, P.P.1    Pandolfi, P.P.2
  • 175
    • 50849110204 scopus 로고    scopus 로고
    • Aptamers in oncology: a diagnostic perspective
    • Khan H, Missailidis S. Aptamers in oncology: a diagnostic perspective. Gene Ther Mol Bio. 2008; 12: 111-28.
    • (2008) Gene Ther Mol Bio , vol.12 , pp. 111-128
    • Khan, H.1    Missailidis, S.2
  • 176
    • 33846120590 scopus 로고    scopus 로고
    • Copper chelation chemistry and its role in copper radiopharmaceuticals
    • Wadas TJ, Wong EH, Weisman GR, et al. Copper chelation chemistry and its role in copper radiopharmaceuticals. Curr Pharm Des. 2007; 13: 3-16.
    • (2007) Curr Pharm Des , vol.13 , pp. 3-16
    • Wadas, T.J.1    Wong, E.H.2    Weisman, G.R.3
  • 177
    • 0036074251 scopus 로고    scopus 로고
    • DOTA-D-Tyr(1)-octreotate: a somatostatin analogue for labeling with metal and halogen radionuclides for cancer imaging and therapy
    • Li WP, Lewis JS, Kim J, et al. DOTA-D-Tyr(1)-octreotate: a somatostatin analogue for labeling with metal and halogen radionuclides for cancer imaging and therapy. Bioconjug Chem. 2002; 13: 721-8.
    • (2002) Bioconjug Chem , vol.13 , pp. 721-728
    • Li, W.P.1    Lewis, J.S.2    Kim, J.3
  • 178
    • 1542328068 scopus 로고    scopus 로고
    • Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes
    • Boswell CA, Sun X, Niu W, et al. Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes. J Med Chem. 2004; 47: 1465-74.
    • (2004) J Med Chem , vol.47 , pp. 1465-1474
    • Boswell, C.A.1    Sun, X.2    Niu, W.3
  • 179
    • 27944457471 scopus 로고    scopus 로고
    • microPET imaging of glioma integrin {alpha}v{beta}3 expression using (64)Cu-labeled tetrameric RGD peptide
    • Wu Y, Zhang X, Xiong Z, et al. microPET imaging of glioma integrin {alpha}v{beta}3 expression using (64)Cu-labeled tetrameric RGD peptide. J Nucl Med. 2005; 46: 1707-18.
    • (2005) J Nucl Med , vol.46 , pp. 1707-1718
    • Wu, Y.1    Zhang, X.2    Xiong, Z.3
  • 180
    • 84892998193 scopus 로고    scopus 로고
    • Aptamer imaging with Cu-64 labeled AS1411: preliminary assessment in lung cancer
    • Li J, Zheng H, Bates PJ, et al. Aptamer imaging with Cu-64 labeled AS1411: preliminary assessment in lung cancer. Nucl Med Biol. 2014; 41: 179-85.
    • (2014) Nucl Med Biol , vol.41 , pp. 179-185
    • Li, J.1    Zheng, H.2    Bates, P.J.3
  • 181
    • 0031279943 scopus 로고    scopus 로고
    • In vivo imaging of inflammation using an aptamer inhibitor of human neutrophil elastase
    • Charlton J, Sennello J, Smith D. In vivo imaging of inflammation using an aptamer inhibitor of human neutrophil elastase. Chem Biol. 1997; 4: 809-16.
    • (1997) Chem Biol , vol.4 , pp. 809-816
    • Charlton, J.1    Sennello, J.2    Smith, D.3
  • 182
    • 84908014746 scopus 로고    scopus 로고
    • Molecular magnetic resonance probe targeting VEGF165: preparation and in vitro and in vivo evaluation
    • [Epub ahead of print]
    • You XG, Tu R, Peng ML, et al. Molecular magnetic resonance probe targeting VEGF165: preparation and in vitro and in vivo evaluation. Contrast Media Mol Imaging. 2014; doi: 10.1002/cmmi.1584. [Epub ahead of print].
    • (2014) Contrast Media Mol Imaging
    • You, X.G.1    Tu, R.2    Peng, M.L.3
  • 183
    • 0032950807 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is a marker of tumor invasion and metastasis in squamous cell carcinomas of the head and neck
    • Sauter ER, Nesbit M, Watson JC, et al. Vascular endothelial growth factor is a marker of tumor invasion and metastasis in squamous cell carcinomas of the head and neck. Clin Cancer Res. 1999; 5: 775-82.
    • (1999) Clin Cancer Res , vol.5 , pp. 775-782
    • Sauter, E.R.1    Nesbit, M.2    Watson, J.C.3
  • 184
    • 0037009827 scopus 로고    scopus 로고
    • Molecular imaging and biological evaluation of HuMV833 anti-VEGF antibody: implications for trial design of antiangiogenic antibodies
    • Jayson GC, Zweit J, Jackson A, et al. Molecular imaging and biological evaluation of HuMV833 anti-VEGF antibody: implications for trial design of antiangiogenic antibodies. J Natl Cancer Inst. 2002; 94: 1484-93.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1484-1493
    • Jayson, G.C.1    Zweit, J.2    Jackson, A.3
  • 185
    • 77952302437 scopus 로고    scopus 로고
    • 89Zr-bevacizumab PET of early antiangiogenic tumor response to treatment with HSP90 inhibitor NVP-AUY922
    • Nagengast WB, de Korte MA, Oude Munnink TH, et al. 89Zr-bevacizumab PET of early antiangiogenic tumor response to treatment with HSP90 inhibitor NVP-AUY922. J Nucl Med. 2010; 51: 761-7.
    • (2010) J Nucl Med , vol.51 , pp. 761-767
    • Nagengast, W.B.1    de Korte, M.A.2    Oude Munnink, T.H.3
  • 186
    • 77957253179 scopus 로고    scopus 로고
    • scVEGF microbubble ultrasound contrast agents: a novel probe for ultrasound molecular imaging of tumor angiogenesis
    • Anderson CR, Rychak JJ, Backer M, et al. scVEGF microbubble ultrasound contrast agents: a novel probe for ultrasound molecular imaging of tumor angiogenesis. Invest Radiol. 2010; 45: 579-85.
    • (2010) Invest Radiol , vol.45 , pp. 579-585
    • Anderson, C.R.1    Rychak, J.J.2    Backer, M.3
  • 187
    • 80053554914 scopus 로고    scopus 로고
    • Introducing Theranostics Journal - From the Editor-in-Chief
    • Chen XS. Introducing Theranostics Journal - From the Editor-in-Chief. Theranostics. 2011; 1: 1-2.
    • (2011) Theranostics , vol.1 , pp. 1-2
    • Chen, X.S.1
  • 188
    • 84870988596 scopus 로고    scopus 로고
    • Theranostic applications: Non-ionizing cellular and molecular imaging through innovative nanosystems for early diagnosis and therapy
    • Casciaro S. Theranostic applications: Non-ionizing cellular and molecular imaging through innovative nanosystems for early diagnosis and therapy. World J Radiol. 2011; 3: 249-55.
    • (2011) World J Radiol , vol.3 , pp. 249-255
    • Casciaro, S.1
  • 190
  • 191
    • 84886997196 scopus 로고    scopus 로고
    • In vivo tumor targeting and image-guided drug delivery with antibody-conjugated, radiolabeled mesoporous silica nanoparticles
    • Chen F, Hong H, Zhang Y, et al. In vivo tumor targeting and image-guided drug delivery with antibody-conjugated, radiolabeled mesoporous silica nanoparticles. ACS Nano. 2013; 7: 9027-39.
    • (2013) ACS Nano , vol.7 , pp. 9027-9039
    • Chen, F.1    Hong, H.2    Zhang, Y.3
  • 192
    • 77955562994 scopus 로고    scopus 로고
    • The complex role of multivalency in nanoparticles targeting the transferrin receptor for cancer therapies
    • Wang J, Tian S, Petros RA, et al. The complex role of multivalency in nanoparticles targeting the transferrin receptor for cancer therapies. J Am Chem Soc. 2010; 132: 11306-13.
    • (2010) J Am Chem Soc , vol.132 , pp. 11306-11313
    • Wang, J.1    Tian, S.2    Petros, R.A.3
  • 193
    • 84904336555 scopus 로고    scopus 로고
    • AuAg/Au nanoparticles assembled with activatable aptamer probes as smart "nano-doctors" for image-guided cancer thermotherapy
    • Shi H, Ye X, He X, et al. AuAg/Au nanoparticles assembled with activatable aptamer probes as smart "nano-doctors" for image-guided cancer thermotherapy. Nanoscale. 2014; 6: 8754-61.
    • (2014) Nanoscale , vol.6 , pp. 8754-8761
    • Shi, H.1    Ye, X.2    He, X.3
  • 194
    • 84874633950 scopus 로고    scopus 로고
    • Theranostic magnetic core-plasmonic shell star shape nanoparticle for the isolation of targeted rare tumor cells from whole blood, fluorescence imaging, and photothermal destruction of cancer
    • Fan Z, Senapati D, Singh AK, et al. Theranostic magnetic core-plasmonic shell star shape nanoparticle for the isolation of targeted rare tumor cells from whole blood, fluorescence imaging, and photothermal destruction of cancer. Mol Pharm. 2013; 10: 857-66.
    • (2013) Mol Pharm , vol.10 , pp. 857-866
    • Fan, Z.1    Senapati, D.2    Singh, A.K.3
  • 195
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell PC. The clonal evolution of tumor cell populations. Science. 1976; 194: 23-8.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 196
    • 52549087785 scopus 로고    scopus 로고
    • Cancer stem cells in solid tumors: accumulating evidence and unresolved questions
    • Visvader JE, Lindeman GJ. Cancer stem cells in solid tumors: accumulating evidence and unresolved questions. Nat Rev Cancer. 2008; 8: 755-68.
    • (2008) Nat Rev Cancer , vol.8 , pp. 755-768
    • Visvader, J.E.1    Lindeman, G.J.2
  • 197
    • 77957868375 scopus 로고    scopus 로고
    • Chromosomal abnormalities in transformed Ph-negative myeloproliferative neoplasms are associated to the transformation subtype and independent of JAK2 and the TET2 mutations
    • Nguyen-Khac F, Lesty C, Eclache V, et al. Chromosomal abnormalities in transformed Ph-negative myeloproliferative neoplasms are associated to the transformation subtype and independent of JAK2 and the TET2 mutations. Genes Chromosomes Cancer. 2010; 49: 919-27.
    • (2010) Genes Chromosomes Cancer , vol.49 , pp. 919-927
    • Nguyen-Khac, F.1    Lesty, C.2    Eclache, V.3
  • 198
    • 69449096005 scopus 로고    scopus 로고
    • Heterogeneity in cancer: cancer stem cells versus clonal evolution
    • Shackleton M, Quintana E, Fearon ER, et al. Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell. 2009; 138: 822-9.
    • (2009) Cell , vol.138 , pp. 822-829
    • Shackleton, M.1    Quintana, E.2    Fearon, E.R.3
  • 199
    • 79957608448 scopus 로고    scopus 로고
    • An increase in cancer stem cell population after primary systemic therapy is a poor prognostic factor in breast cancer
    • Lee HE, Kim JH, Kim YJ, et al. An increase in cancer stem cell population after primary systemic therapy is a poor prognostic factor in breast cancer. Br J Cancer. 2011; 104: 1730-8.
    • (2011) Br J Cancer , vol.104 , pp. 1730-1738
    • Lee, H.E.1    Kim, J.H.2    Kim, Y.J.3
  • 200
    • 80055003796 scopus 로고    scopus 로고
    • A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumors
    • Beck B, Driessens G, Goossens S, et al. A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumors. Nature. 2011; 478: 399-403.
    • (2011) Nature , vol.478 , pp. 399-403
    • Beck, B.1    Driessens, G.2    Goossens, S.3
  • 201
    • 84856226651 scopus 로고    scopus 로고
    • Cancer stem cells: an evolving concept
    • Nguyen LV, Vanner R, Dirks P, et al. Cancer stem cells: an evolving concept. Nat Rev Cancer. 2012; 12: 133-43.
    • (2012) Nat Rev Cancer , vol.12 , pp. 133-143
    • Nguyen, L.V.1    Vanner, R.2    Dirks, P.3
  • 202
    • 84871681506 scopus 로고    scopus 로고
    • The Implications of Cancer Stem Cells for Cancer Therapy
    • Jiang W, Peng J, Zhang Y, et al. The Implications of Cancer Stem Cells for Cancer Therapy. Int J Mol Sci. 2012; 13: 16636-57.
    • (2012) Int J Mol Sci , vol.13 , pp. 16636-16657
    • Jiang, W.1    Peng, J.2    Zhang, Y.3
  • 203
    • 84856501335 scopus 로고    scopus 로고
    • The developing cancer stem-cell model: clinical challenges and opportunities
    • Vermeulen L, de Sousa e Melo F, Richel DJ, et al. The developing cancer stem-cell model: clinical challenges and opportunities. Lancet Oncol. 2012; 13: e83-9.
    • (2012) Lancet Oncol , vol.13 , pp. e83-e89
    • Vermeulen, L.1    de Sousa, E.M.F.2    Richel, D.J.3
  • 204
    • 79956351015 scopus 로고    scopus 로고
    • Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
    • Chaffer CL, Brueckmann I, Scheel C, et al. Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci U S A. 2011; 108: 7950-5.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 7950-7955
    • Chaffer, C.L.1    Brueckmann, I.2    Scheel, C.3
  • 205
    • 79958265710 scopus 로고    scopus 로고
    • Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    • Scheel C, Eaton EN, Li SH-J, et al. Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell. 2011; 145: 926-40.
    • (2011) Cell , vol.145 , pp. 926-940
    • Scheel, C.1    Eaton, E.N.2    Li, S.-J.3
  • 206
    • 84856501335 scopus 로고    scopus 로고
    • The developing cancer stem-cell model: clinical challenges and opportunities
    • Vermeulen L, de Sousa e Melo F, Richel DJ, et al. The developing cancer stem-cell model: clinical challenges and opportunities. Lancet Oncol. 2012; 13: e83-e89.
    • (2012) Lancet Oncol , vol.13 , pp. e83-e89
    • Vermeulen, L.1    de Sousa Melo, F.2    Richel, D.J.3
  • 207
    • 48249122739 scopus 로고    scopus 로고
    • Current status and issues in cancer stem cell study
    • Yang YM, Chang JW. Current status and issues in cancer stem cell study. Cancer Invest. 2008; 26: 741-55.
    • (2008) Cancer Invest , vol.26 , pp. 741-755
    • Yang, Y.M.1    Chang, J.W.2
  • 208
    • 79951831708 scopus 로고    scopus 로고
    • Targeting Wnt signaling in colon cancer stem cells
    • de Sousa EM, Vermeulen L, Richel D, et al. Targeting Wnt signaling in colon cancer stem cells. Clin Cancer Res. 2011; 17: 647-53.
    • (2011) Clin Cancer Res , vol.17 , pp. 647-653
    • de Sousa, E.M.1    Vermeulen, L.2    Richel, D.3
  • 209
    • 77649339258 scopus 로고    scopus 로고
    • Reduction of CD44(+)/CD24(-) breast cancer cells by conventional cytotoxic chemotherapy
    • Aulmann S, Waldburger N, Penzel R, et al. Reduction of CD44(+)/CD24(-) breast cancer cells by conventional cytotoxic chemotherapy. Hum Pathol. 2010; 41: 574-81.
    • (2010) Hum Pathol , vol.41 , pp. 574-581
    • Aulmann, S.1    Waldburger, N.2    Penzel, R.3
  • 210
    • 77955773149 scopus 로고    scopus 로고
    • Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironment
    • Resetkova E, Reis-Filho JS, Jain RK, et al. Prognostic impact of ALDH1 in breast cancer: a story of stem cells and tumor microenvironment. Breast Cancer Res Treat. 2010; 123: 97-108.
    • (2010) Breast Cancer Res Treat , vol.123 , pp. 97-108
    • Resetkova, E.1    Reis-Filho, J.S.2    Jain, R.K.3
  • 211
    • 48949119473 scopus 로고    scopus 로고
    • Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
    • Fillmore CM, Kuperwasser C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res. 2008; 10: R25.
    • (2008) Breast Cancer Res , vol.10
    • Fillmore, C.M.1    Kuperwasser, C.2
  • 212
    • 34547197024 scopus 로고    scopus 로고
    • Spheres isolated from 9L gliosarcoma rat cell line possess chemoresistant and aggressive cancer stem-like cells
    • Ghods AJ, Irvin D, Liu G, et al. Spheres isolated from 9L gliosarcoma rat cell line possess chemoresistant and aggressive cancer stem-like cells. Stem Cells. 2007; 25: 1645-53.
    • (2007) Stem Cells , vol.25 , pp. 1645-1653
    • Ghods, A.J.1    Irvin, D.2    Liu, G.3
  • 214
    • 84877666481 scopus 로고    scopus 로고
    • CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches
    • Williams K, Motiani K, Giridhar PV, et al. CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches. Exp Biol Med (Maywood). 2013; 238: 324-38.
    • (2013) Exp Biol Med (Maywood) , vol.238 , pp. 324-338
    • Williams, K.1    Motiani, K.2    Giridhar, P.V.3
  • 215
    • 84881638389 scopus 로고    scopus 로고
    • Lung cancer stem cells: a biological and clinical perspective
    • Koren A, Motaln H, Cufer T. Lung cancer stem cells: a biological and clinical perspective. Cell Oncol (Dordr). 2013; 36: 265-75.
    • (2013) Cell Oncol (Dordr) , vol.36 , pp. 265-275
    • Koren, A.1    Motaln, H.2    Cufer, T.3
  • 216
    • 84882847908 scopus 로고    scopus 로고
    • Gastric cancer stem cells: A novel therapeutic target
    • Singh SR. Gastric cancer stem cells: A novel therapeutic target. Cancer Lett. 2013; 338: 110-9.
    • (2013) Cancer Lett , vol.338 , pp. 110-119
    • Singh, S.R.1
  • 217
    • 84867919330 scopus 로고    scopus 로고
    • Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy
    • McAuliffe SM, Morgan SL, Wyant GA, et al. Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy. Proc Natl Acad Sci U S A. 2012; 109: E2939-48.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E2939-E2948
    • McAuliffe, S.M.1    Morgan, S.L.2    Wyant, G.A.3
  • 218
    • 75149117750 scopus 로고    scopus 로고
    • Elimination of human lung cancer stem cells through targeting of the stem cell factor-c-kit autocrine signaling loop
    • Levina V, Marrangoni A, Wang T, et al. Elimination of human lung cancer stem cells through targeting of the stem cell factor-c-kit autocrine signaling loop. Cancer Res. 2010; 70: 338-46.
    • (2010) Cancer Res , vol.70 , pp. 338-346
    • Levina, V.1    Marrangoni, A.2    Wang, T.3
  • 219
    • 84896879273 scopus 로고    scopus 로고
    • Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells
    • Li L, Xiang D, Shigdar S, et al. Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells. Int J Nanomedicine. 2014; 9: 1083-96.
    • (2014) Int J Nanomedicine , vol.9 , pp. 1083-1096
    • Li, L.1    Xiang, D.2    Shigdar, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.