-
1
-
-
0035499267
-
Stem cells, cancer, and cancer stem cells
-
Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105-11.
-
(2001)
Nature
, vol.414
, pp. 105-111
-
-
Reya, T.1
Morrison, S.J.2
Clarke, M.F.3
Weissman, I.L.4
-
2
-
-
16844368698
-
Tumour stem cells and drug resistance
-
Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 2005;5:275-84.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 275-284
-
-
Dean, M.1
Fojo, T.2
Bates, S.3
-
3
-
-
58149345546
-
Co-evolution of tumor cells and their microenvironment
-
Polyak K, Haviv I, Campbell IG. Co-evolution of tumor cells and their microenvironment. Trends Genet 2009;25:30-8.
-
(2009)
Trends Genet
, vol.25
, pp. 30-38
-
-
Polyak, K.1
Haviv, I.2
Campbell, I.G.3
-
4
-
-
0037388204
-
Prospective identification of tumorigenic breast cancer cells
-
Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 2003;100:3983-8.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 3983-3988
-
-
Al-Hajj, M.1
Wicha, M.S.2
Benito-Hernandez, A.3
Morrison, S.J.4
Clarke, M.F.5
-
5
-
-
9244241576
-
Identification of human brain tumour initiating cells
-
Singh SK, Hawkins C, Clarke ID, et al. Identification of human brain tumour initiating cells. Nature 2004;432:396-401.
-
(2004)
Nature
, vol.432
, pp. 396-401
-
-
Singh, S.K.1
Hawkins, C.2
Clarke, I.D.3
-
7
-
-
34548455927
-
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
-
Hermann PC, Huber SL, Herrler C, et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 2007;1:313-23.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 313-323
-
-
Hermann, P.C.1
Huber, S.L.2
Herrler, C.3
-
8
-
-
33846095137
-
Identification and expansion of human colon-cancer-initiating cells
-
Ricci-Vitiani L, Lombardi DG, Pilozzi E, et al. Identification and expansion of human colon-cancer-initiating cells. Nature 2007;445: 111-5.
-
(2007)
Nature
, vol.445
, pp. 111-115
-
-
Ricci-Vitiani, L.1
Lombardi, D.G.2
Pilozzi, E.3
-
9
-
-
39449088496
-
Identification and expansion of the tumorigenic lung cancer stem cell population
-
Eramo A, Lotti F, Sette G, et al. Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death Differ 2008; 15:504-14.
-
(2008)
Cell Death Differ
, vol.15
, pp. 504-514
-
-
Eramo, A.1
Lotti, F.2
Sette, G.3
-
10
-
-
52449091004
-
Drugselected human lung cancer stem cells: Cytokine network, tumorigenic and metastatic properties
-
Levina V, Marrangoni AM, DeMarco R, Gorelik E, Lokshin AE. Drugselected human lung cancer stem cells: cytokine network, tumorigenic and metastatic properties. PLoS One 2008;3:e3077.
-
(2008)
PLoS One
, vol.3
-
-
Levina, V.1
Marrangoni, A.M.2
DeMarco, R.3
Gorelik, E.4
Lokshin, A.E.5
-
11
-
-
0037948854
-
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
-
Dontu G, Abdallah WM, Foley JM, et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev 2003;17:1253-70.
-
(2003)
Genes Dev
, vol.17
, pp. 1253-1270
-
-
Dontu, G.1
Abdallah, W.M.2
Foley, J.M.3
-
12
-
-
0036737914
-
Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro
-
Ignatova TN, Kukekov VG, Laywell ED, Suslov ON, Vrionis FD, Steindler DA. Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vitro. Glia 2002; 39:193-206.
-
(2002)
Glia
, vol.39
, pp. 193-206
-
-
Ignatova, T.N.1
Kukekov, V.G.2
Laywell, E.D.3
Suslov, O.N.4
Vrionis, F.D.5
Steindler, D.A.6
-
14
-
-
34248140257
-
Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimens
-
Miki J, Furusato B, Li H, et al. Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimens. Cancer Res 2007;67:3153-61.
-
(2007)
Cancer Res
, vol.67
, pp. 3153-3161
-
-
Miki, J.1
Furusato, B.2
Li, H.3
-
15
-
-
51649109943
-
Chemotherapeutic drugs and human tumor cells cytokine network
-
Levina V, Su Y, Nolen B, et al. Chemotherapeutic drugs and human tumor cells cytokine network. Int J Cancer;123:2031-40.
-
Int J Cancer
, vol.123
, pp. 2031-2040
-
-
Levina, V.1
Su, Y.2
Nolen, B.3
-
16
-
-
33644867457
-
The stem cell factor receptor/c-Kit as a drug target in cancer
-
Lennartsson J, Ronnstrand L. The stem cell factor receptor/c-Kit as a drug target in cancer. Curr Cancer Drug Targets 2006;6:65-75.
-
(2006)
Curr Cancer Drug Targets
, vol.6
, pp. 65-75
-
-
Lennartsson, J.1
Ronnstrand, L.2
-
17
-
-
36849078711
-
let-7 regulates self renewal and tumorigenicity of breast cancer cells
-
Yu F, Yao H, Zhu P, et al. let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 2007;131:1109-23.
-
(2007)
Cell
, vol.131
, pp. 1109-1123
-
-
Yu, F.1
Yao, H.2
Zhu, P.3
-
18
-
-
33645772227
-
Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain
-
Sun L, Hui AM, Su Q, et al. Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell 2006;9: 287-300.
-
(2006)
Cancer Cell
, vol.9
, pp. 287-300
-
-
Sun, L.1
Hui, A.M.2
Su, Q.3
-
19
-
-
0025741284
-
Requirement for mast cell growth factor for primordial germ cell survival in culture
-
Dolci S, Williams DE, Ernst MK, et al. Requirement for mast cell growth factor for primordial germ cell survival in culture. Nature 1991;352:809-11.
-
(1991)
Nature
, vol.352
, pp. 809-811
-
-
Dolci, S.1
Williams, D.E.2
Ernst, M.K.3
-
20
-
-
0030846533
-
Stem cell factor and hematopoiesis
-
Broudy VC. Stem cell factor and hematopoiesis. Blood 1997;90: 1345-64.
-
(1997)
Blood
, vol.90
, pp. 1345-1364
-
-
Broudy, V.C.1
-
21
-
-
0030069519
-
Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor
-
Krystal GW, Hines SJ, Organ CP. Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor. Cancer Res 1996;56:370-6.
-
(1996)
Cancer Res
, vol.56
, pp. 370-376
-
-
Krystal, G.W.1
Hines, S.J.2
Organ, C.P.3
-
23
-
-
34547830309
-
Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway
-
Yasuda A, Sawai H, Takahashi H, et al. Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway. Dig Dis Sci 2007;52:2292-300.
-
(2007)
Dig Dis Sci
, vol.52
, pp. 2292-2300
-
-
Yasuda, A.1
Sawai, H.2
Takahashi, H.3
-
24
-
-
2342518106
-
Efficacy and safety of imatinib in adult patients with c-kit-positive acute myeloid leukemia
-
Kindler T, Breitenbuecher F, Marx A, et al. Efficacy and safety of imatinib in adult patients with c-kit-positive acute myeloid leukemia. Blood 2004;103:3644-54.
-
(2004)
Blood
, vol.103
, pp. 3644-3654
-
-
Kindler, T.1
Breitenbuecher, F.2
Marx, A.3
-
25
-
-
55049139546
-
c-Kit expression in human normal and malignant stem cells prognostic and therapeutic implications
-
Hassan HT. c-Kit expression in human normal and malignant stem cells prognostic and therapeutic implications. Leuk Res 2008;33:5-10.
-
(2008)
Leuk Res
, vol.33
, pp. 5-10
-
-
Hassan, H.T.1
-
26
-
-
43649099086
-
Turning promiscuous kinase inhibitors into safer drugs
-
Zhang X, Crespo A, Fernandez A. Turning promiscuous kinase inhibitors into safer drugs. Trends Biotechnol 2008;26:295-301.
-
(2008)
Trends Biotechnol
, vol.26
, pp. 295-301
-
-
Zhang, X.1
Crespo, A.2
Fernandez, A.3
-
27
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 2001;344:1031-7.
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
-
28
-
-
33750595859
-
Molecular correlates of imatinib resistance in gastrointestinal stromal tumors
-
Heinrich MC, Corless CL, Blanke CD, et al. Molecular correlates of imatinib resistance in gastrointestinal stromal tumors. J Clin Oncol 2006;24:4764-74.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4764-4774
-
-
Heinrich, M.C.1
Corless, C.L.2
Blanke, C.D.3
-
29
-
-
53049094588
-
Imatinib mesylate (Gleevec) in advanced breast cancer-expressing C-Kit or PDGFR-β: Clinical activity and biological correlations
-
Cristofanilli M, Morandi P, Krishnamurthy S, et al. Imatinib mesylate (Gleevec) in advanced breast cancer-expressing C-Kit or PDGFR-β: clinical activity and biological correlations. Ann Oncol 2008;19: 1713-9.
-
(2008)
Ann Oncol
, vol.19
, pp. 1713-1719
-
-
Cristofanilli, M.1
Morandi, P.2
Krishnamurthy, S.3
-
30
-
-
34447318659
-
Phase II trial of imatinib mesylate in recurrent, biomarker positive, ovarian cancer (Southwest Oncology Group Protocol S0211)
-
Alberts DS, Liu PY, Wilczynski SP, et al. Phase II trial of imatinib mesylate in recurrent, biomarker positive, ovarian cancer (Southwest Oncology Group Protocol S0211). Int J Gynecol Cancer 2007;17: 784-8.
-
(2007)
Int J Gynecol Cancer
, vol.17
, pp. 784-788
-
-
Alberts, D.S.1
Liu, P.Y.2
Wilczynski, S.P.3
-
31
-
-
18044381919
-
Imatinib mesylate lacks activity in small cell lung carcinoma expressing c-kit protein: A phase II clinical trial
-
Krug LM, Crapanzano JP, Azzoli CG, et al. Imatinib mesylate lacks activity in small cell lung carcinoma expressing c-kit protein: a phase II clinical trial. Cancer 2005;103:2128-31.
-
(2005)
Cancer
, vol.103
, pp. 2128-2131
-
-
Krug, L.M.1
Crapanzano, J.P.2
Azzoli, C.G.3
-
32
-
-
40949129917
-
Multiple effects of TRAIL in human carcinoma cells: Induction of apoptosis, senescence, proliferation, and cytokine production
-
Levina V, Marrangoni AM, Demarco R, Gorelik E, Lokshin AE. Multiple effects of TRAIL in human carcinoma cells: induction of apoptosis, senescence, proliferation, and cytokine production. Exp Cell Res 2008;314:1605-16.
-
(2008)
Exp Cell Res
, vol.314
, pp. 1605-1616
-
-
Levina, V.1
Marrangoni, A.M.2
Demarco, R.3
Gorelik, E.4
Lokshin, A.E.5
-
33
-
-
1942506722
-
Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro
-
Houghton PJ, Germain GS, Harwood FC, et al. Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro. Cancer Res 2004;64:2333-7.
-
(2004)
Cancer Res
, vol.64
, pp. 2333-2337
-
-
Houghton, P.J.1
Germain, G.S.2
Harwood, F.C.3
-
34
-
-
0032545642
-
Expression of the c-Kit receptor and its ligand SCF in non-small-cell lung carcinomas
-
Pietsch T, Nicotra MR, Fraioli R, Wolf HK, Mottolese M, Natali PG. Expression of the c-Kit receptor and its ligand SCF in non-small-cell lung carcinomas. Int J Cancer 1998;75:171-5.
-
(1998)
Int J Cancer
, vol.75
, pp. 171-175
-
-
Pietsch, T.1
Nicotra, M.R.2
Fraioli, R.3
Wolf, H.K.4
Mottolese, M.5
Natali, P.G.6
-
35
-
-
0034254249
-
Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor
-
Heinrich MC, Griffith DJ, Druker BJ, Wait CL, Ott KA, Zigler AJ. Inhibition of c-kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor. Blood 2000;96:925-32.
-
(2000)
Blood
, vol.96
, pp. 925-932
-
-
Heinrich, M.C.1
Griffith, D.J.2
Druker, B.J.3
Wait, C.L.4
Ott, K.A.5
Zigler, A.J.6
-
36
-
-
43049095679
-
Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma
-
Kubo T, Piperdi S, Rosenblum J, et al. Platelet-derived growth factor receptor as a prognostic marker and a therapeutic target for imatinib mesylate therapy in osteosarcoma. Cancer 2008;112:2119-29.
-
(2008)
Cancer
, vol.112
, pp. 2119-2129
-
-
Kubo, T.1
Piperdi, S.2
Rosenblum, J.3
-
37
-
-
0842311601
-
Imatinib mesylate (Gleevec) inhibits ovarian cancer cell growth through a mechanism dependent on platelet-derived growth factor receptor α and Akt inactivation
-
Matei D, Chang DD, Jeng MH. Imatinib mesylate (Gleevec) inhibits ovarian cancer cell growth through a mechanism dependent on platelet-derived growth factor receptor α and Akt inactivation. Clin Cancer Res 2004;10:681-90.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 681-690
-
-
Matei, D.1
Chang, D.D.2
Jeng, M.H.3
-
38
-
-
0642368571
-
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
-
Heinrich MC, Corless CL, Demetri GD, et al. Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol 2003;21:4342-9.
-
(2003)
J Clin Oncol
, vol.21
, pp. 4342-4349
-
-
Heinrich, M.C.1
Corless, C.L.2
Demetri, G.D.3
-
39
-
-
33748861663
-
Mechanisms of resistance to small molecule kinase inhibition in the treatment of solid tumors
-
Rubin BP, Duensing A. Mechanisms of resistance to small molecule kinase inhibition in the treatment of solid tumors. Lab Invest 2006;86: 981-6.
-
(2006)
Lab Invest
, vol.86
, pp. 981-986
-
-
Rubin, B.P.1
Duensing, A.2
-
40
-
-
33645218010
-
Strategies to overcome resistance to targeted protein kinase inhibitors in the treatment of cancer
-
Buschbeck M. Strategies to overcome resistance to targeted protein kinase inhibitors in the treatment of cancer. Drugs R D 2006;7:73-86.
-
(2006)
Drugs R D
, vol.7
, pp. 73-86
-
-
Buschbeck, M.1
-
41
-
-
10444280878
-
Strategies to overcome resistance to targeted protein kinase inhibitors
-
Daub H, Specht K, Ullrich A. Strategies to overcome resistance to targeted protein kinase inhibitors. Nat Rev Drug Discov 2004;3: 1001-10.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 1001-1010
-
-
Daub, H.1
Specht, K.2
Ullrich, A.3
-
42
-
-
0033996762
-
The IκB kinase (IKK) and NF-κB: Key elements of proinflammatory signalling
-
Karin M, Delhase M. The IκB kinase (IKK) and NF-κB: key elements of proinflammatory signalling. Semin Immunol 2000;12:85-98.
-
(2000)
Semin Immunol
, vol.12
, pp. 85-98
-
-
Karin, M.1
Delhase, M.2
-
44
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
46
-
-
33744903660
-
Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms
-
Tarn C, Skorobogatko YV, Taguchi T, Eisenberg B, von Mehren M, Godwin AK. Therapeutic effect of imatinib in gastrointestinal stromal tumors: AKT signaling dependent and independent mechanisms. Cancer Res 2006;66:5477-86.
-
(2006)
Cancer Res
, vol.66
, pp. 5477-5486
-
-
Tarn, C.1
Skorobogatko, Y.V.2
Taguchi, T.3
Eisenberg, B.4
von Mehren, M.5
Godwin, A.K.6
-
47
-
-
33947322052
-
AKT mediates the pro-survival effects of KIT in ovarian cancer cells and is a determinant of sensitivity to imatinib mesylate
-
Shaw TJ, Vanderhyden BC. AKT mediates the pro-survival effects of KIT in ovarian cancer cells and is a determinant of sensitivity to imatinib mesylate. Gynecol Oncol 2007;105:122-31.
-
(2007)
Gynecol Oncol
, vol.105
, pp. 122-131
-
-
Shaw, T.J.1
Vanderhyden, B.C.2
-
48
-
-
21744437791
-
Repopulation of cancer cells during therapy: An important cause of treatment failure
-
Kim JJ, Tannock IF. Repopulation of cancer cells during therapy: an important cause of treatment failure. Nat Rev Cancer 2005;5: 516-25.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 516-525
-
-
Kim, J.J.1
Tannock, I.F.2
|