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Volumn 3, Issue NOV, 2012, Pages

Current progress of RNA aptamer-based therapeutics

Author keywords

RNA aptamers; RNA interference; Small interfering RNA; Systematic evolution of ligands by exponential enrichment; Targeted delivery

Indexed keywords


EID: 84875171615     PISSN: None     EISSN: 16648021     Source Type: Journal    
DOI: 10.3389/fgene.2012.00234     Document Type: Review
Times cited : (116)

References (122)
  • 1
    • 33845723241 scopus 로고    scopus 로고
    • An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform
    • Bagalkot, V., Farokhzad, O. C., Langer, R., and Jon, S. (2006). An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform. Angew. Chem. Int. Ed. Engl. 45, 8149-8152.
    • (2006) Angew. Chem. Int. Ed. Engl. , vol.45 , pp. 8149-8152
    • Bagalkot, V.1    Farokhzad, O.C.2    Langer, R.3    Jon, S.4
  • 2
    • 80055004444 scopus 로고    scopus 로고
    • siRNA-aptamer chimeras on nanoparticles: preserving targeting functionality for effective gene silencing
    • Bagalkot,V., and Gao, X. (2011). siRNA-aptamer chimeras on nanoparticles: preserving targeting functionality for effective gene silencing. ACS Nano 5, 8131-8139.
    • (2011) ACS Nano , vol.5 , pp. 8131-8139
    • Bagalkot, V.1    Gao, X.2
  • 3
    • 84863395411 scopus 로고    scopus 로고
    • Age-dependent changes in the cerebrospinal fluid proteome by slow off-rate modified aptamer array
    • Baird, G. S., Nelson, S. K., Keeney, T. R., Stewart, A., Williams, S.,Kraemer,S., et al. (2012). Age-dependent changes in the cerebrospinal fluid proteome by slow off-rate modified aptamer array. Am. J. Pathol. 180,446-456.
    • (2012) Am. J. Pathol. , vol.180 , pp. 446-456
    • Baird, G.S.1    Nelson, S.K.2    Keeney, T.R.3    Stewart, A.4    Williams, S.5    Kraemer, S.6
  • 5
    • 84859064398 scopus 로고    scopus 로고
    • Bidirectional relationship between functional connectivity and amyloid-beta deposition in mouse brain
    • Bero, A. W., Bauer, A. Q., Stewart, F. R., White, B. R., Cirrito, J. R., Raichle, M. E., et al. (2012). Bidirectional relationship between functional connectivity and amyloid-beta deposition in mouse brain. J. Neurosci. 32, 4334-4340.
    • (2012) J. Neurosci. , vol.32 , pp. 4334-4340
    • Bero, A.W.1    Bauer, A.Q.2    Stewart, F.R.3    White, B.R.4    Cirrito, J.R.5    Raichle, M.E.6
  • 6
    • 79951821247 scopus 로고    scopus 로고
    • A reversible aptamer improves outcome and safety in murine models of stroke and hemorrhage
    • Blake, C. M., Wang, H., Laskowitz, D. T., and Sullenger, B. A. (2011). A reversible aptamer improves outcome and safety in murine models of stroke and hemorrhage. Oligonu-cleotides 21, 11-19.
    • (2011) Oligonu-cleotides , vol.21 , pp. 11-19
    • Blake, C.M.1    Wang, H.2    Laskowitz, D.T.3    Sullenger, B.A.4
  • 7
    • 55549114664 scopus 로고    scopus 로고
    • The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities
    • Bonci, D., Coppola, V., Musumeci, M., Addario, A., Giuffrida, R., Memeo, L., et al. (2008). The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities. Nat. Med. 14, 1271-1277.
    • (2008) Nat. Med. , vol.14 , pp. 1271-1277
    • Bonci, D.1    Coppola, V.2    Musumeci, M.3    Addario, A.4    Giuffrida, R.5    Memeo, L.6
  • 9
    • 84856389509 scopus 로고    scopus 로고
    • RNA-based therapeutics: current progress and future prospects
    • Burnett, J. C., and Rossi, J. J. (2012). RNA-based therapeutics: current progress and future prospects. Chem. Biol. 19, 60-71.
    • (2012) Chem. Biol. , vol.19 , pp. 60-71
    • Burnett, J.C.1    Rossi, J.J.2
  • 10
    • 80052627990 scopus 로고    scopus 로고
    • Current progress of siRNA/shRNA therapeutics in clinical trials
    • Burnett, J. C., Rossi, J. J., and Tiemann, K. (2011). Current progress of siRNA/shRNA therapeutics in clinical trials. Biotechnol. J. 6, 1130-1146.
    • (2011) Biotechnol. J. , vol.6 , pp. 1130-1146
    • Burnett, J.C.1    Rossi, J.J.2    Tiemann, K.3
  • 11
    • 18344375927 scopus 로고    scopus 로고
    • Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase
    • doi:10.1371/journal.pbio.0030123
    • Cerchia, L., Duconge, F., Pestourie, C., Boulay, J., Aissouni, Y., Gombert, K., et al. (2005). Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase. PLoS Biol. 3, e123. doi:10.1371/journal.pbio.0030123
    • (2005) PLoS Biol , vol.3
    • Cerchia, L.1    Duconge, F.2    Pestourie, C.3    Boulay, J.4    Aissouni, Y.5    Gombert, K.6
  • 12
    • 34548118342 scopus 로고    scopus 로고
    • A general framework for quantifying the effects of DNA repair inhibitors on radiation sensitivity as a function of dose
    • Chalmers, A. J., Bentzen, S. M., and Buffa, F. M. (2007). A general framework for quantifying the effects of DNA repair inhibitors on radiation sensitivity as a function of dose. Theor. Biol. Med. Model. 4,25.
    • (2007) Theor. Biol. Med. Model. , vol.4 , pp. 25
    • Chalmers, A.J.1    Bentzen, S.M.2    Buffa, F.M.3
  • 13
    • 0041923790 scopus 로고    scopus 로고
    • Inhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3
    • Chen, C. H., Chernis, G. A., Hoang, V. Q., and Landgraf, R. (2003). Inhibition of heregulin signaling by an aptamer that preferentially binds to the oligomeric form of human epidermal growth factor receptor-3. Proc. Natl. Acad. Sci. U.S.A. 100, 9226-9231.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 9226-9231
    • Chen, C.H.1    Chernis, G.A.2    Hoang, V.Q.3    Landgraf, R.4
  • 15
    • 33750503424 scopus 로고    scopus 로고
    • Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery
    • Cheng, J., Teply, B. A., Sherifi, I., Sung, J., Luther, G., Gu, F. X., et al. (2007). Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery. Biomaterials 28, 869-876.
    • (2007) Biomaterials , vol.28 , pp. 869-876
    • Cheng, J.1    Teply, B.A.2    Sherifi, I.3    Sung, J.4    Luther, G.5    Gu, F.X.6
  • 16
    • 77952368550 scopus 로고    scopus 로고
    • Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    • Chiang, H. R., Schoenfeld, L. W., Ruby, J. G., Auyeung, V. C., Spies, N., Baek, D., et al. (2010). Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev. 24, 992-1009.
    • (2010) Genes Dev , vol.24 , pp. 992-1009
    • Chiang, H.R.1    Schoenfeld, L.W.2    Ruby, J.G.3    Auyeung, V.C.4    Spies, N.5    Baek, D.6
  • 19
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers, H. (2006). Wnt/beta-catenin signaling in development and disease. Cell 127, 469-480.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 20
    • 0037382008 scopus 로고    scopus 로고
    • Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors
    • Collis, S. J., Swartz, M. J., Nelson, W G., and Deweese, T. L. (2003). Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors. Cancer Res. 63, 1550-1554.
    • (2003) Cancer Res , vol.63 , pp. 1550-1554
    • Collis, S.J.1    Swartz, M.J.2    Nelson, W.G.3    Deweese, T.L.4
  • 21
    • 0021751840 scopus 로고
    • The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
    • Dalgleish, A. G., Beverley, P. C., Clapham, P. R., Crawford, D. H., Greaves, M. F., and Weiss, R. A. (1984). The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312, 763-767.
    • (1984) Nature , vol.312 , pp. 763-767
    • Dalgleish, A.G.1    Beverley, P.C.2    Clapham, P.R.3    Crawford, D.H.4    Greaves, M.F.5    Weiss, R.A.6
  • 22
    • 80052435113 scopus 로고    scopus 로고
    • Dual blockade of the homeostatic chemokine CXCL12 and the proinflammatory chemokine CCL2 has additive protective effects on diabetic kidney disease
    • Darisipudi, M. N., Kulkarni, O. P., Sayyed, S. G., Ryu, M., Migliorini, A., Sagrinati, C., et al. (2011). Dual blockade of the homeostatic chemokine CXCL12 and the proinflammatory chemokine CCL2 has additive protective effects on diabetic kidney disease. Am. J. Pathol. 179, 116-124.
    • (2011) Am. J. Pathol. , vol.179 , pp. 116-124
    • Darisipudi, M.N.1    Kulkarni, O.P.2    Sayyed, S.G.3    Ryu, M.4    Migliorini, A.5    Sagrinati, C.6
  • 23
    • 70249110439 scopus 로고    scopus 로고
    • Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors
    • Dassie, J. P., Liu, X. Y., Thomas, G. S., Whitaker, R. M., Thiel, K. W., Stockdale, K. R., et al. (2009). Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nat. Biotechnol. 27, 839-849.
    • (2009) Nat. Biotechnol. , vol.27 , pp. 839-849
    • Dassie, J.P.1    Liu, X.Y.2    Thomas, G.S.3    Whitaker, R.M.4    Thiel, K.W.5    Stockdale, K.R.6
  • 24
    • 79954580272 scopus 로고    scopus 로고
    • Current prospects for RNA interference-based therapies
    • Davidson, B. L., and McCray, P. B. Jr. (2011). Current prospects for RNA interference-based therapies. Nat. Rev. Genet. 12, 329-340.
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 329-340
    • Davidson, B.L.1    McCray Jr., P.B.2
  • 25
    • 78651380337 scopus 로고    scopus 로고
    • New therapeutic approaches in breast cancer
    • Davies, E., and Hiscox, S. (2011). New therapeutic approaches in breast cancer. Maturitas 68,121-128.
    • (2011) Maturitas , vol.68 , pp. 121-128
    • Davies, E.1    Hiscox, S.2
  • 27
    • 84870397199 scopus 로고    scopus 로고
    • Tissue plasminogen activator and stroke: review of the literature for the clinician
    • [Epub ahead of print]
    • Demers, G., Meurer, W. J., Shih, R., Rosenbaum, S., and Vilke, G. M. (2012). Tissue plasminogen activator and stroke: review of the literature for the clinician. J. Emerg. Med. PMID:22818644. [Epub ahead of print].
    • (2012) J. Emerg. Med.
    • Demers, G.1    Meurer, W.J.2    Shih, R.3    Rosenbaum, S.4    Vilke, G.M.5
  • 29
    • 56249097260 scopus 로고    scopus 로고
    • Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles
    • Dhar, S., Gu, F. X., Langer, R., Farokhzad, O. C., and Lippard, S. J. (2008). Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Proc. Natl. Acad. Sci. U.S.A. 105,17356-17361.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 17356-17361
    • Dhar, S.1    Gu, F.X.2    Langer, R.3    Farokhzad, O.C.4    Lippard, S.J.5
  • 31
    • 79958744392 scopus 로고    scopus 로고
    • Nucleic acid aptamers targeting cell-surface proteins
    • Dua, P., Kim, S., and Lee, D. K. (2011). Nucleic acid aptamers targeting cell-surface proteins. Methods 54,215-225.
    • (2011) Methods , vol.54 , pp. 215-225
    • Dua, P.1    Kim, S.2    Lee, D.K.3
  • 32
    • 0035839867 scopus 로고    scopus 로고
    • Translocations involving anaplastic lymphoma kinase (ALK)
    • Duyster, J., Bai, R. Y., and Morris, S. W. (2001). Translocations involving anaplastic lymphoma kinase (ALK). Oncogene 20, 5623-5637.
    • (2001) Oncogene , vol.20 , pp. 5623-5637
    • Duyster, J.1    Bai, R.Y.2    Morris, S.W.3
  • 33
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21 -nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., and Tuschl, T. (2001). Duplexes of 21 -nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411,494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 34
    • 0025074907 scopus 로고
    • In vitro selection of RNA molecules that bind specific ligands
    • Ellington, A. D., and Szostak, J. W. (1990). In vitro selection of RNA molecules that bind specific ligands. Nature 346, 818-822.
    • (1990) Nature , vol.346 , pp. 818-822
    • Ellington, A.D.1    Szostak, J.W.2
  • 35
    • 80052441290 scopus 로고    scopus 로고
    • A neutralizing RNA aptamer against EGFR causes selective apoptotic cell death
    • doi:10.1371/journal.pone.0024071
    • Esposito, C. L., Passaro, D., Longobardo, I., Condorelli, G., Marotta, P., Affuso, A., et al. (2011). A neutralizing RNA aptamer against EGFR causes selective apoptotic cell death. PLoS ONE 6, e24071. doi:10.1371/journal.pone.0024071
    • (2011) PLoS ONE , vol.6
    • Esposito, C.L.1    Passaro, D.2    Longobardo, I.3    Condorelli, G.4    Marotta, P.5    Affuso, A.6
  • 36
    • 7444223607 scopus 로고    scopus 로고
    • Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells
    • Farokhzad, O. C. (2004). Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells. Cancer Res. 64, 7668-7672.
    • (2004) Cancer Res , vol.64 , pp. 7668-7672
    • Farokhzad, O.C.1
  • 37
    • 33646582037 scopus 로고    scopus 로고
    • Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo
    • Farokhzad, O. C. (2006). Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc. Natl Acad. Sci. U.S.A 103,6315-6320.
    • (2006) Proc. Natl Acad. Sci. U. S. A , vol.103 , pp. 6315-6320
    • Farokhzad, O.C.1
  • 38
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., and Mello, C. C. (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 39
    • 40649105534 scopus 로고    scopus 로고
    • Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers
    • Gu, F., Zhang, L., Teply, B. A., Mann, N., Wang, A., Radovic-Moreno, A. F., et al. (2008). Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers. Proc. Natl. Acad. Sci. U.S.A. 105,2586-2591.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 2586-2591
    • Gu, F.1    Zhang, L.2    Teply, B.A.3    Mann, N.4    Wang, A.5    Radovic-Moreno, A.F.6
  • 40
    • 78649985789 scopus 로고    scopus 로고
    • The emerging field of RNA nanotechnology
    • Guo, P. (2010). The emerging field of RNA nanotechnology. Nat. Nanotechnol. 5, 833-842.
    • (2010) Nat. Nanotechnol. , vol.5 , pp. 833-842
    • Guo, P.1
  • 41
    • 24944512987 scopus 로고    scopus 로고
    • Specific delivery of therapeutic RNAs to cancer cells via the dimerization mechanism of phi29 motor pRNA
    • Guo, S., Tschammer, N., Mohammed, S., and Guo, P. (2005). Specific delivery of therapeutic RNAs to cancer cells via the dimerization mechanism of phi29 motor pRNA. Hum. Gene Ther. 16, 1097-1109.
    • (2005) Hum. Gene Ther. , vol.16 , pp. 1097-1109
    • Guo, S.1    Tschammer, N.2    Mohammed, S.3    Guo, P.4
  • 42
    • 0035966106 scopus 로고    scopus 로고
    • Tenascin-C aptamers are generated using tumor cells and purified protein
    • Hicke, B. J., Marion, C., Chang, Y. F., Gould, T., Lynott, C. K., Parma, D., et al. (2001). Tenascin-C aptamers are generated using tumor cells and purified protein. J. Biol. Chem. 276, 48644-48654.
    • (2001) J. Biol. Chem. , vol.276 , pp. 48644-48654
    • Hicke, B.J.1    Marion, C.2    Chang, Y.F.3    Gould, T.4    Lynott, C.K.5    Parma, D.6
  • 44
    • 77956702018 scopus 로고    scopus 로고
    • Biological considerations and clinical applications of new HER2-targeted agents
    • Higa, G. M., Singh, V., and Abraham, J. (2010). Biological considerations and clinical applications of new HER2-targeted agents. Expert Rev. Anticancer Ther. 10, 1497-1509.
    • (2010) Expert Rev. Anticancer Ther. , vol.10 , pp. 1497-1509
    • Higa, G.M.1    Singh, V.2    Abraham, J.3
  • 45
    • 77952500494 scopus 로고    scopus 로고
    • Strategies for in vivo delivery of siRNAs: recent progress
    • Higuchi, Y., Kawakami, S., and Hashida, M. (2010). Strategies for in vivo delivery of siRNAs: recent progress. BioDrugs 24,195-205.
    • (2010) BioDrugs , vol.24 , pp. 195-205
    • Higuchi, Y.1    Kawakami, S.2    Hashida, M.3
  • 46
    • 0035151050 scopus 로고    scopus 로고
    • Highly specific antiangiogenic therapy is effective in suppressing growth of experimental Wilms tumors
    • Huang, J., Moore, J., Soffer, S., Kim, E., Rowe,D.,Manley,C.A.,etal. (2001). Highly specific antiangiogenic therapy is effective in suppressing growth of experimental Wilms tumors. J. Pediatr. Surg. 36, 357-361.
    • (2001) J. Pediatr. Surg. , vol.36 , pp. 357-361
    • Huang, J.1    Moore, J.2    Soffer, S.3    Kim, E.4    Rowe, D.5    Manley, C.A.6
  • 47
    • 67651166851 scopus 로고    scopus 로고
    • One RNA aptamer sequence, two structures: a collaborating pair that inhibits AMPA receptors
    • Huang,Z.,Pei,W.,Han,Y.,Jayaseelan,S., Shekhtman,A.,Shi, H.,etal. (2009). One RNA aptamer sequence, two structures: a collaborating pair that inhibits AMPA receptors. Nucleic Acids Res. 37, 4022-4032.
    • (2009) Nucleic Acids Res , vol.37 , pp. 4022-4032
    • Huang, Z.1    Pei, W.2    Han, Y.3    Jayaseelan, S.4    Shekhtman, A.5    Shi, H.6
  • 48
    • 0023864652 scopus 로고
    • A soluble CD4 protein selectively inhibits HIV replication and syncytium formation
    • Hussey, R. E., Richardson, N. E., Kowalski, M., Brown, N. R., Chang, H. C., Siliciano, R. F., et al. (1988). A soluble CD4 protein selectively inhibits HIV replication and syncytium formation. Nature 331, 78-81.
    • (1988) Nature , vol.331 , pp. 78-81
    • Hussey, R.E.1    Richardson, N.E.2    Kowalski, M.3    Brown, N.R.4    Chang, H.C.5    Siliciano, R.F.6
  • 49
    • 79551676198 scopus 로고    scopus 로고
    • Therapeutic potential of anti-interleukin-17A aptamer: suppression of interleukin-17A signaling and attenuation of autoimmunity in two mouse models
    • Ishiguro, A., Akiyama, T., Adachi, H., Inoue, J., and Nakamura, Y. (2011). Therapeutic potential of anti-interleukin-17A aptamer: suppression of interleukin-17A signaling and attenuation of autoimmunity in two mouse models. Arthritis Rheum. 63, 455-466.
    • (2011) Arthritis Rheum , vol.63 , pp. 455-466
    • Ishiguro, A.1    Akiyama, T.2    Adachi, H.3    Inoue, J.4    Nakamura, Y.5
  • 50
    • 0034814741 scopus 로고    scopus 로고
    • In vitro selection of the RNA aptamer against the Sialyl Lewis X and its inhibition of the cell adhesion
    • Jeong, S., Eom, T., Kim, S., Lee, S., and Yu, J. (2001). In vitro selection of the RNA aptamer against the Sialyl Lewis X and its inhibition of the cell adhesion. Biochem. Biophys. Res. Commun. 281,237-43.
    • (2001) Biochem. Biophys. Res. Commun. , vol.281 , pp. 237-243
    • Jeong, S.1    Eom, T.2    Kim, S.3    Lee, S.4    Yu, J.5
  • 51
    • 84869432243 scopus 로고    scopus 로고
    • RNA aptamers: a review of recent trends and applications
    • [Epub ahead of print]
    • Kang, K. N., and Lee, Y. S. (2012). RNA aptamers: a review of recent trends and applications. Adv. Biochem. Eng. Biotechnol. PMID:22491855. [Epub ahead of print].
    • (2012) Adv. Biochem. Eng. Biotechnol.
    • Kang, K.N.1    Lee, Y.S.2
  • 52
    • 0027479864 scopus 로고
    • Uniformly modified 2/-deoxy-2/-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets
    • Kawasaki, A. M., Casper, M. D., Freier, S. M., Lesnik, E. A., Zounes, M. C., Cummins, L. L., et al. (1993). Uniformly modified 2/-deoxy-2/-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets. J. Med. Chem. 36,831-841.
    • (1993) J. Med. Chem. , vol.36 , pp. 831-841
    • Kawasaki, A.M.1    Casper, M.D.2    Freier, S.M.3    Lesnik, E.A.4    Zounes, M.C.5    Cummins, L.L.6
  • 54
    • 24944565527 scopus 로고    scopus 로고
    • Controllable self-assembly of nanoparticles for specific delivery of multiple therapeutic molecules to cancer cells using RNA nanotechnology
    • Khaled, A., Guo, S., Li, F., and Guo, P. (2005). Controllable self-assembly of nanoparticles for specific delivery of multiple therapeutic molecules to cancer cells using RNA nanotechnology. Nano Lett. 5, 1797-1808.
    • (2005) Nano Lett , vol.5 , pp. 1797-1808
    • Khaled, A.1    Guo, S.2    Li, F.3    Guo, P.4
  • 55
    • 77950051368 scopus 로고    scopus 로고
    • Prostate cancer cell death produced by the co-delivery of Bcl-xL shRNA and doxorubicin using an aptamer-conjugated polyplex
    • Kim, E., Jung, Y., Choi, H., Yang, J., Suh, J. S., Huh, Y M., et al. (2010). Prostate cancer cell death produced by the co-delivery of Bcl-xL shRNA and doxorubicin using an aptamer-conjugated polyplex. Biomaterials 31,4592-4599.
    • (2010) Biomaterials , vol.31 , pp. 4592-4599
    • Kim, E.1    Jung, Y.2    Choi, H.3    Yang, J.4    Suh, J.S.5    Huh, Y.M.6
  • 56
    • 0032081316 scopus 로고    scopus 로고
    • Cutting edge: novel RNA ligands able to bind CD4 antigen and inhibit CD4+ T lymphocyte function
    • Kraus, E., James, W., and Barclay, A. N. (1998). Cutting edge: novel RNA ligands able to bind CD4 antigen and inhibit CD4+ T lymphocyte function.J. Immunol. 160,5209-5212.
    • (1998) J. Immunol. , vol.160 , pp. 5209-5212
    • Kraus, E.1    James, W.2    Barclay, A.N.3
  • 57
    • 60149094505 scopus 로고    scopus 로고
    • RNA interference: from basic research to therapeutic applications
    • Kurreck, J. (2009). RNA interference: from basic research to therapeutic applications. Angew. Chem. Int. Ed. Engl. 48,1378-1398.
    • (2009) Angew. Chem. Int. Ed. Engl. , vol.48 , pp. 1378-1398
    • Kurreck, J.1
  • 58
    • 80054681184 scopus 로고    scopus 로고
    • Targeted chemoim-munotherapy using drug-loaded aptamer-dendrimer bioconjugates
    • Lee, I. H., An, S., Yu, M. K., Kwon, H. K., Im, S. H., and Jon, S. (2011). Targeted chemoim-munotherapy using drug-loaded aptamer-dendrimer bioconjugates. J. Control. Release 155,435-441.
    • (2011) J. Control. Release , vol.155 , pp. 435-441
    • Lee, I.H.1    An, S.2    Yu, M.K.3    Kwon, H.K.4    Im, S.H.5    Jon, S.6
  • 59
    • 84855803788 scopus 로고    scopus 로고
    • Regression of hepatocarcinoma cells using RNA aptamer specific to alpha-fetoprotein
    • Lee, Y J., and Lee, S. W. (2012). Regression of hepatocarcinoma cells using RNA aptamer specific to alpha-fetoprotein. Biochem. Biophys. Res. Commun. 417,521-527.
    • (2012) Biochem. Biophys. Res. Commun. , vol.417 , pp. 521-527
    • Lee, Y.J.1    Lee, S.W.2
  • 62
    • 79958158761 scopus 로고    scopus 로고
    • Inhibition of cell proliferation by an anti-EGFR aptamer
    • doi:10.1371/journal.pone.0020299
    • Li, N., Nguyen, H. H., Byrom, M., and Ellington, A. D. (2011). Inhibition of cell proliferation by an anti-EGFR aptamer. PLoS ONE 6, e20299. doi:10.1371/journal.pone.0020299
    • (2011) PLoS ONE , vol.6
    • Li, N.1    Nguyen, H.H.2    Byrom, M.3    Ellington, A.D.4
  • 63
    • 33745601099 scopus 로고    scopus 로고
    • Stem cells for the treatment of neurological disorders
    • Lindvall, O., and Kokaia, Z. (2006). Stem cells for the treatment of neurological disorders. Nature 441, 1094-1096.
    • (2006) Nature , vol.441 , pp. 1094-1096
    • Lindvall, O.1    Kokaia, Z.2
  • 64
    • 0032530135 scopus 로고    scopus 로고
    • Constitutive and antibody-induced internalization of prostate-specific membrane antigen
    • Liu, H., Rajasekaran, A. K., Moy, P., Xia, Y., Kim, S., Navarro, V., et al. (1998). Constitutive and antibody-induced internalization of prostate-specific membrane antigen. Cancer Res. 58, 4055-4060.
    • (1998) Cancer Res , vol.58 , pp. 4055-4060
    • Liu, H.1    Rajasekaran, A.K.2    Moy, P.3    Xia, Y.4    Kim, S.5    Navarro, V.6
  • 65
    • 0037862005 scopus 로고    scopus 로고
    • Targeting the variable surface of African trypanosomes with variant surface glycoprotein-specific, serum-stable RNA aptamers
    • Lorger, M., Engstler, M., Homann, M., and Goringer, H. U. (2003). Targeting the variable surface of African trypanosomes with variant surface glycoprotein-specific, serum-stable RNA aptamers. Eukaryotic Cell 2, 84-94.
    • (2003) Eukaryotic Cell , vol.2 , pp. 84-94
    • Lorger, M.1    Engstler, M.2    Homann, M.3    Goringer, H.U.4
  • 66
    • 0037099536 scopus 로고    scopus 로고
    • Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen
    • Lupold, S. E., Hicke, B. J., Lin, Y., and Coffey, D. S. (2002). Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen. Cancer Res. 62, 4029-4033.
    • (2002) Cancer Res , vol.62 , pp. 4029-4033
    • Lupold, S.E.1    Hicke, B.J.2    Lin, Y.3    Coffey, D.S.4
  • 68
    • 77958517935 scopus 로고    scopus 로고
    • Identification of thioaptamer ligand against E-selectin: potential application for inflamed vasculature targeting
    • doi:10.1371/journal.pone.00 13050
    • Mann, A. P., Somasunderam, A., Nieves-Alicea, R., Li, X., Hu, A., Sood, A. K., et al. (2010). Identification of thioaptamer ligand against E-selectin: potential application for inflamed vasculature targeting. PLoS ONE 5, e13050. doi:10.1371/journal.pone.00 13050
    • (2010) PLoS ONE , vol.5
    • Mann, A.P.1    Somasunderam, A.2    Nieves-Alicea, R.3    Li, X.4    Hu, A.5    Sood, A.K.6
  • 69
    • 0035834076 scopus 로고    scopus 로고
    • beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
    • Masliah, E., Rockenstein, E., Veinbergs, I., Sagara, Y., Mallory, M., Hashimoto, M., et al. (2001). beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proc. Natl. Acad. Sci. U.S.A. 98, 12245-12250.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 12245-12250
    • Masliah, E.1    Rockenstein, E.2    Veinbergs, I.3    Sagara, Y.4    Mallory, M.5    Hashimoto, M.6
  • 70
    • 70349786346 scopus 로고    scopus 로고
    • The chemical biology of aptamers
    • Mayer, G. (2009). The chemical biology of aptamers. Angew. Chem. Int. Ed. Engl. 48, 2672-2689.
    • (2009) Angew. Chem. Int. Ed. Engl. , vol.48 , pp. 2672-2689
    • Mayer, G.1
  • 72
    • 78651419151 scopus 로고    scopus 로고
    • Dual-aptamer-based delivery vehicle of doxorubicin to both PSMA (+) and PSMA (-) prostate cancers
    • Min, K., Jo, H., Song, K., Cho, M., Chun, Y. S., Jon, S., et al. (2011). Dual-aptamer-based delivery vehicle of doxorubicin to both PSMA (+) and PSMA (-) prostate cancers. Biomaterials 32, 2124-2132.
    • (2011) Biomaterials , vol.32 , pp. 2124-2132
    • Min, K.1    Jo, H.2    Song, K.3    Cho, M.4    Chun, Y.S.5    Jon, S.6
  • 73
    • 34547922452 scopus 로고    scopus 로고
    • Targeting the function of the HER2 oncogene in human cancer therapeutics
    • Moasser, M. M. (2007). Targeting the function of the HER2 oncogene in human cancer therapeutics. Oncogene 26, 6577-6592.
    • (2007) Oncogene , vol.26 , pp. 6577-6592
    • Moasser, M.M.1
  • 74
    • 11344278689 scopus 로고    scopus 로고
    • RNA aptamers selected against the receptor activator of NF-kappaB acquire general affinity to proteins of the tumor necrosis factor receptor family
    • Mori, T., Oguro, A., Ohtsu, T., and Nakamura, Y (2004). RNA aptamers selected against the receptor activator of NF-kappaB acquire general affinity to proteins of the tumor necrosis factor receptor family. Nucleic Acids Res. 32, 6120-6128.
    • (2004) Nucleic Acids Res , vol.32 , pp. 6120-6128
    • Mori, T.1    Oguro, A.2    Ohtsu, T.3    Nakamura, Y.4
  • 75
    • 62449161815 scopus 로고    scopus 로고
    • Anti-bovine prion protein RNA aptamer containing tandem GGA repeat interacts both with recombinant bovine prion protein and its beta isoform with high affinity
    • Murakami, K., Nishikawa, F., Noda, K., Yokoyama, T., and Nishikawa, S. (2008). Anti-bovine prion protein RNA aptamer containing tandem GGA repeat interacts both with recombinant bovine prion protein and its beta isoform with high affinity. Prion 2, 73-80.
    • (2008) Prion , vol.2 , pp. 73-80
    • Murakami, K.1    Nishikawa, F.2    Noda, K.3    Yokoyama, T.4    Nishikawa, S.5
  • 76
    • 79953325739 scopus 로고    scopus 로고
    • Midkine: a promising molecule for drug development to treat diseases of the central nervous system
    • Muramatsu, T. (2011). Midkine: a promising molecule for drug development to treat diseases of the central nervous system. Curr. Pharm. Des. 17,410-423.
    • (2011) Curr. Pharm. Des. , vol.17 , pp. 410-423
    • Muramatsu, T.1
  • 78
    • 80052228547 scopus 로고    scopus 로고
    • Nucleic acid aptamers: clinical applications and promising new horizons
    • Ni, X., Castanares, M., Mukherjee, A., and Lupold, S. E. (2011a). Nucleic acid aptamers: clinical applications and promising new horizons. Curr. Med. Chem. 18,4206-4214.
    • (2011) Curr. Med. Chem. , vol.18 , pp. 4206-4214
    • Ni, X.1    Castanares, M.2    Mukherjee, A.3    Lupold, S.E.4
  • 79
    • 79957920185 scopus 로고    scopus 로고
    • Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumorxenografts
    • Ni, X., Zhang, Y., Ribas, J., Chowdhury, W. H., Castanares, M., Zhang, Z., et al. (2011b). Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumorxenografts. J. Clin. Invest. 121, 2383-2390.
    • (2011) J. Clin. Invest. , vol.121 , pp. 2383-2390
    • Ni, X.1    Zhang, Y.2    Ribas, J.3    Chowdhury, W.H.4    Castanares, M.5    Zhang, Z.6
  • 80
  • 81
    • 33748459890 scopus 로고    scopus 로고
    • siRNA targeting NBS1 or XIAP increases radiation sensitivity of human cancer cells independent of TP53 status
    • Ohnishi, K., Scuric, Z., Schiestl, R. H., Okamoto, N., Takahashi, A., and Ohnishi, T. (2006). siRNA targeting NBS1 or XIAP increases radiation sensitivity of human cancer cells independent of TP53 status. Radiat. Res. 166, 454-462.
    • (2006) Radiat. Res. , vol.166 , pp. 454-462
    • Ohnishi, K.1    Scuric, Z.2    Schiestl, R.H.3    Okamoto, N.4    Takahashi, A.5    Ohnishi, T.6
  • 82
    • 79955425830 scopus 로고    scopus 로고
    • Potent and selective inhibition of a single alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit by an RNA aptamer
    • Park, J. S., Wang, C., Han, Y., Huang, Z., and Niu, L. (2011). Potent and selective inhibition of a single alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit by an RNA aptamer. J. Biol. Chem. 286, 15608-15617.
    • (2011) J. Biol. Chem. , vol.286 , pp. 15608-15617
    • Park, J.S.1    Wang, C.2    Han, Y.3    Huang, Z.4    Niu, L.5
  • 83
    • 77952380547 scopus 로고    scopus 로고
    • Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay
    • Pastor, F., Kolonias, D., Giangrande, P. H., and Gilboa, E. (2010). Induction of tumour immunity by targeted inhibition of nonsense-mediated mRNA decay. Nature 465, 227-230.
    • (2010) Nature , vol.465 , pp. 227-230
    • Pastor, F.1    Kolonias, D.2    Giangrande, P.H.3    Gilboa, E.4
  • 84
    • 0026032662 scopus 로고
    • Differential endocytosis of CD4 in lym-phocytic and nonlymphocytic cells
    • Pelchen-Matthews, A., Armes, J. E., Griffiths, G., and Marsh, M. (1991). Differential endocytosis of CD4 in lym-phocytic and nonlymphocytic cells. J. Exp. Med. 173, 575-587.
    • (1991) J. Exp. Med. , vol.173 , pp. 575-587
    • Pelchen-Matthews, A.1    Armes, J.E.2    Griffiths, G.3    Marsh, M.4
  • 86
    • 80055107642 scopus 로고    scopus 로고
    • Selection of aptamers for amyloid beta-protein, the causative agent of Alzheimer's disease
    • doi:10.3791/1955
    • Rahimi, F., and Bitan, G. (2010). Selection of aptamers for amyloid beta-protein, the causative agent of Alzheimer's disease. J. Vis. Exp. doi:10.3791/1955
    • (2010) J. Vis. Exp.
    • Rahimi, F.1    Bitan, G.2
  • 87
    • 70450159254 scopus 로고    scopus 로고
    • RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity
    • doi:10.1371/journal.pone.0007694
    • Rahimi, F., Murakami, K., Summers, J. L., Chen, C. H., and Bitan, G. (2009). RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity. PLoS ONE 4, e7694. doi:10.1371/journal.pone.0007694
    • (2009) PLoS ONE , vol.4
    • Rahimi, F.1    Murakami, K.2    Summers, J.L.3    Chen, C.H.4    Bitan, G.5
  • 88
    • 33748164764 scopus 로고    scopus 로고
    • RNA aptamers selectively modulate protein recruitment to the cytoplasmic domain of beta-secretase BACE1 in vitro.
    • Rentmeister, A., Bill, A., Wahle, T., Walter, J., and Famulok, M. (2006). RNA aptamers selectively modulate protein recruitment to the cytoplasmic domain of beta-secretase BACE1 in vitro. RNA 12, 1650-1660.
    • (2006) RNA , vol.12 , pp. 1650-1660
    • Rentmeister, A.1    Bill, A.2    Wahle, T.3    Walter, J.4    Famulok, M.5
  • 89
    • 0141891211 scopus 로고    scopus 로고
    • Characterization of 2/-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion
    • Rhie, A., Kirby, L., Sayer, N., Wellesley, R., Disterer, P., Sylvester, I., et al. (2003). Characterization of 2/-fluoro-RNA aptamers that bind preferentially to disease-associated conformations of prion protein and inhibit conversion. J. Biol. Chem. 278, 39697-39705.
    • (2003) J. Biol. Chem. , vol.278 , pp. 39697-39705
    • Rhie, A.1    Kirby, L.2    Sayer, N.3    Wellesley, R.4    Disterer, P.5    Sylvester, I.6
  • 90
    • 84858202940 scopus 로고    scopus 로고
    • Aptamer-mediated blockade of IL4Ralpha triggers apoptosis of MDSCs and limits tumor progression
    • Roth, F., De La Fuente, A. C., Vella, J. L., Zoso, A., Inverardi, L., and Serafini, P. (2012). Aptamer-mediated blockade of IL4Ralpha triggers apoptosis of MDSCs and limits tumor progression. Cancer Res. 72, 1373-1383.
    • (2012) Cancer Res , vol.72 , pp. 1373-1383
    • Roth, F.1    De La Fuente, A.C.2    Vella, J.L.3    Zoso, A.4    Inverardi, L.5    Serafini, P.6
  • 91
    • 0037026484 scopus 로고    scopus 로고
    • RNA aptamers as reversible antagonists of coagulation factor IXa
    • Rusconi, C. P., Scardino, E., Layzer, J., Pitoc, G. A., Ortel, T. L., Monroe, D., et al. (2002). RNA aptamers as reversible antagonists of coagulation factor IXa. Nature 419, 90-94.
    • (2002) Nature , vol.419 , pp. 90-94
    • Rusconi, C.P.1    Scardino, E.2    Layzer, J.3    Pitoc, G.A.4    Ortel, T.L.5    Monroe, D.6
  • 92
    • 84856402483 scopus 로고    scopus 로고
    • A status update of modified oligonucleotides for chemotherapeutics applications
    • Sanghvi, Y. S. (2011). A status update of modified oligonucleotides for chemotherapeutics applications. Curr. Protoc. Nucleic Acid Chem. 4, 1-22.
    • (2011) Curr. Protoc. Nucleic Acid Chem. , vol.4 , pp. 1-22
    • Sanghvi, Y.S.1
  • 93
    • 0242610799 scopus 로고    scopus 로고
    • Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity
    • Santulli-Marotto, S., Nair, S. K., Rusconi, C., Sullenger, B., and Gilboa, E. (2003). Multivalent RNA aptamers that inhibit CTLA-4 and enhance tumor immunity. Cancer Res. 63, 7483-7489.
    • (2003) Cancer Res , vol.63 , pp. 7483-7489
    • Santulli-Marotto, S.1    Nair, S.K.2    Rusconi, C.3    Sullenger, B.4    Gilboa, E.5
  • 94
    • 70349882090 scopus 로고    scopus 로고
    • Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes
    • Sayyed, S. G., Hagele, H., Kulkarni, O. P., Endlich, K., Segerer, S., Eulberg, D., et al. (2009). Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomeruloscle-rosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes. Diabetologia 52,2445-2454.
    • (2009) Diabetologia , vol.52 , pp. 2445-2454
    • Sayyed, S.G.1    Hagele, H.2    Kulkarni, O.P.3    Endlich, K.4    Segerer, S.5    Eulberg, D.6
  • 96
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr, C. J. (1996). Cancer cell cycles. Science 274, 1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 97
    • 79953171803 scopus 로고    scopus 로고
    • Assembly of multifunctional phi29 pRNA nanoparticles for specific delivery of siRNA and other therapeutics to targeted cells
    • Shu, Y., Cinier, M., Shu, D., and Guo, P. (2011). Assembly of multifunctional phi29 pRNA nanoparticles for specific delivery of siRNA and other therapeutics to targeted cells. Methods 54,204-214.
    • (2011) Methods , vol.54 , pp. 204-214
    • Shu, Y.1    Cinier, M.2    Shu, D.3    Guo, P.4
  • 98
    • 0033187884 scopus 로고    scopus 로고
    • The biology of human epidermal growth factor receptor 2
    • Sundaresan, S., Penuel, E., and Sliwkowski, M. X. (1999). The biology of human epidermal growth factor receptor 2. Curr. Oncol. Rep. 1, 16-22.
    • (1999) Curr. Oncol. Rep. , vol.1 , pp. 16-22
    • Sundaresan, S.1    Penuel, E.2    Sliwkowski, M.X.3
  • 99
    • 78049328110 scopus 로고    scopus 로고
    • Advances in aptamers
    • Syed, M. A., and Pervaiz, S. (2010). Advances in aptamers. Oligonucleotides 20,215-224.
    • (2010) Oligonucleotides , vol.20 , pp. 215-224
    • Syed, M.A.1    Pervaiz, S.2
  • 101
    • 0034797419 scopus 로고    scopus 로고
    • A unique folate hydrolase, prostate-specific membrane antigen (PSMA): a target for immunotherapy?
    • Tasch, J., Gong, M., Sadelain, M., and Heston, W. D. (2001). A unique folate hydrolase, prostate-specific membrane antigen (PSMA): a target for immunotherapy? Crit. Rev. Immunol. 21,249-261.
    • (2001) Crit. Rev. Immunol. , vol.21 , pp. 249-261
    • Tasch, J.1    Gong, M.2    Sadelain, M.3    Heston, W.D.4
  • 102
    • 70349272617 scopus 로고    scopus 로고
    • Therapeutic applications of DNA and RNA aptamers
    • Thiel, K. W., and Giangrande, P. H. (2009). Therapeutic applications of DNA and RNA aptamers. Oligonucleotides 19, 209-222.
    • (2009) Oligonucleotides , vol.19 , pp. 209-222
    • Thiel, K.W.1    Giangrande, P.H.2
  • 103
    • 79954481313 scopus 로고    scopus 로고
    • Intracellular delivery of RNA-based therapeutics using aptamers
    • Thiel, K. W., and Giangrande, P. H. (2010). Intracellular delivery of RNA-based therapeutics using aptamers. Ther. Deliv. 1, 849-861.
    • (2010) Ther. Deliv. , vol.1 , pp. 849-861
    • Thiel, K.W.1    Giangrande, P.H.2
  • 104
    • 84864447484 scopus 로고    scopus 로고
    • Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers
    • Thiel, K. W., Hernandez, L. I., Dassie, J. P., Thiel, W H., Liu, X., Stockdale, K. R., et al. (2012). Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers. Nucleic Acids Res. 40, 6319-6337.
    • (2012) Nucleic Acids Res , vol.40 , pp. 6319-6337
    • Thiel, K.W.1    Hernandez, L.I.2    Dassie, J.P.3    Thiel, W.H.4    Liu, X.5    Stock-dale, K.R.6
  • 105
    • 79951525187 scopus 로고    scopus 로고
    • Systemic and ocular safety of intravitreal anti-VEGF therapies for ocular neovascular disease
    • Tolentino, M. (2011). Systemic and ocular safety of intravitreal anti-VEGF therapies for ocular neovascular disease. Surv. Ophthalmol. 56, 95-113.
    • (2011) Surv. Ophthalmol. , vol.56 , pp. 95-113
    • Tolentino, M.1
  • 106
    • 0025194307 scopus 로고
    • Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
    • Tuerk, C., and Gold, L. (1990). Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249, 505-510.
    • (1990) Science , vol.249 , pp. 505-510
    • Tuerk, C.1    Gold, L.2
  • 107
    • 34548755527 scopus 로고    scopus 로고
    • Pegaptanib in the treatment of wet, age-related macular degeneration
    • Vinores, S. A. (2006). Pegaptanib in the treatment of wet, age-related macular degeneration. Int. J. Nanomedicine 1,263-268.
    • (2006) Int. J. Nanomedicine , vol.1 , pp. 263-268
    • Vinores, S.A.1
  • 108
    • 54849404705 scopus 로고    scopus 로고
    • Superparamagnetic iron oxide nanoparticle-aptamer biocon-jugates for combined prostate cancer imaging and therapy
    • Wang, A. Z., Bagalkot, V., Vasilliou, C. C., Gu, F., Alexis, F., Zhang, L., et al. (2008a). Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy. ChemMedChem.3, 1311-1315.
    • (2008) ChemMedChem. , vol.3 , pp. 1311-1315
    • Wang, A.Z.1    Bagalkot, V.2    Vasilliou, C.C.3    Gu, F.4    Alexis, F.5    Zhang, L.6
  • 109
    • 41649100722 scopus 로고    scopus 로고
    • Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell population
    • Wang, J., Takeuchi, H., Sonobe, Y., Jin, S., Mizuno, T., Miyakawa, S., et al. (2008b). Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell population. Proc. Natl. Acad. Sci. U.S.A. 105,3915-3920.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 3915-3920
    • Wang, J.1    Takeuchi, H.2    Sonobe, Y.3    Jin, S.4    Mizuno, T.5    Miyakawa, S.6
  • 110
    • 77954965749 scopus 로고    scopus 로고
    • Aptamer antagonists of myelin-derived inhibitors promote axon growth
    • doi:10.1371/journal.pone.0009726
    • Wang, Y., Khaing, Z. Z., Li, N., Hall, B., Schmidt, C. E., and Ellington, A. D. (2010). Aptamer antagonists of myelin-derived inhibitors promote axon growth. PLoS ONE 5, e9726. doi:10.1371/journal.pone.0009726
    • (2010) PLoS ONE , vol.5
    • Wang, Y.1    Khaing, Z.Z.2    Li, N.3    Hall, B.4    Schmidt, C.E.5    Ellington, A.D.6
  • 112
    • 84862833395 scopus 로고    scopus 로고
    • Second-generation ap tamer-conjugated PSMA-targeted delivery system for prostate cancer therapy
    • Wu, X., Ding, B., Gao, J., Wang, H., Fan, W., Wang, X., et al. (2011). Second-generation ap tamer-conjugated PSMA-targeted delivery system for prostate cancer therapy. Int. J. Nanomedicine 6,1747-1756.
    • (2011) Int. J. Nanomedicine , vol.6 , pp. 1747-1756
    • Wu, X.1    Ding, B.2    Gao, J.3    Wang, H.4    Fan, W.5    Wang, X.6
  • 113
    • 55449127119 scopus 로고    scopus 로고
    • Cell-specific induction of apoptosis by rationally designed bivalent aptamer-siRNA transcripts silencing eukaryotic elongation factor 2
    • Wullner, U., Neef, I., Eller, A., Kleines, M., Tur, M. K., and Barth, S. (2008). Cell-specific induction of apoptosis by rationally designed bivalent aptamer-siRNA transcripts silencing eukaryotic elongation factor 2. Curr. Cancer Drug Targets 8, 554-565.
    • (2008) Curr. Cancer Drug Targets , vol.8 , pp. 554-565
    • Wullner, U.1    Neef, I.2    Eller, A.3    Kleines, M.4    Tur, M.K.5    Barth, S.6
  • 114
    • 0037408391 scopus 로고    scopus 로고
    • The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI
    • Yamashita, T., and Tohyama, M. (2003). The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. Nat. Neurosci. 6,461-467.
    • (2003) Nat. Neurosci. , vol.6 , pp. 461-467
    • Yamashita, T.1    Tohyama, M.2
  • 115
    • 84866641974 scopus 로고    scopus 로고
    • Prostate-targeted biodegradable nanoparticles loaded with androgen receptor silencing constructs eradicate xenograft tumors in mice
    • Yang, J., Xie, S. X., Huang, Y., Ling, M., Liu, J., Ran, Y., et al. (2012). Prostate-targeted biodegradable nanoparticles loaded with androgen receptor silencing constructs eradicate xenograft tumors in mice. Nanomedicine (Lond). 7,1297-1309.
    • (2012) Nanomedicine (Lond) , vol.7 , pp. 1297-1309
    • Yang, J.1    Xie, S.X.2    Huang, Y.3    Ling, M.4    Liu, J.5    Ran, Y.6
  • 116
    • 0034766736 scopus 로고    scopus 로고
    • Biology of HER2 and its importance in breast cancer
    • Yarden, Y (2001). Biology of HER2 and its importance in breast cancer. Oncology 61(Suppl. 2), 1-13.
    • (2001) Oncology , vol.61 , Issue.SUPPL. 2 , pp. 1-13
    • Yarden, Y.1
  • 117
    • 0036289319 scopus 로고    scopus 로고
    • Selection of RNA aptamers to the Alzheimer's disease amyloid peptide
    • Ylera, F., Lurz, R., Erdmann, V. A., and Furste, J. P. (2002). Selection of RNA aptamers to the Alzheimer's disease amyloid peptide. Biochem. Biophys. Res. Commun. 290, 1583-1588.
    • (2002) Biochem. Biophys. Res. Commun. , vol.290 , pp. 1583-1588
    • Ylera, F.1    Lurz, R.2    Erdmann, V.A.3    Furste, J.P.4
  • 118
    • 42349106952 scopus 로고    scopus 로고
    • Co-delivery of hydrophobic and hydrophilic drugs from nanoparticle-aptamer biocon-jugates
    • Zhang, L., Radovic-Moreno, A. F., Alexis, F., Gu, E X., Basto, P. A., Bagalkot, V., et al. (2007). Co-delivery of hydrophobic and hydrophilic drugs from nanoparticle-aptamer biocon-jugates. ChemMedChem. 2, 1268-1271.
    • (2007) ChemMedChem , vol.2 , pp. 1268-1271
    • Zhang, L.1    Radovic-Moreno, A.F.2    Alexis, F.3    Gu, E.X.4    Basto, P.A.5    Bagalkot, V.6
  • 119
    • 70549112254 scopus 로고    scopus 로고
    • Using an RNA aptamer probe for flow cytometry detection of CD30-expressing lymphoma cells
    • Zhang, P., Zhao, N., Zeng, Z., Feng, Y., Tung, C. H., Chang, C. C., et al. (2009). Using an RNA aptamer probe for flow cytometry detection of CD30-expressing lymphoma cells. Lab. Invest. 89, 1423-1432.
    • (2009) Lab. Invest. , vol.89 , pp. 1423-1432
    • Zhang, P.1    Zhao, N.2    Zeng, Z.3    Feng, Y.4    Tung, C.H.5    Chang, C.C.6
  • 120
    • 79251568958 scopus 로고    scopus 로고
    • A nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma
    • Zhao, N., Bagaria, H. G., Wong, M. S., and Zu, Y (2011). A nanocomplex that is both tumor cell-selective and cancer gene-specific for anaplastic large cell lymphoma. J. Nanobiotechnology 9,2.
    • (2011) J. Nanobiotechnology , vol.9 , pp. 2
    • Zhao, N.1    Bagaria, H.G.2    Wong, M.S.3    Zu, Y.4
  • 121
    • 77954362096 scopus 로고    scopus 로고
    • Aptamer-targeted cell-specific RNA interference
    • Zhou, J., and Rossi, J. J. (2010). Aptamer-targeted cell-specific RNA interference. Silence 1,4.
    • (2010) Silence , vol.1 , pp. 4
    • Zhou, J.1    Rossi, J.J.2
  • 122
    • 79951818184 scopus 로고    scopus 로고
    • Cell-specific aptamer-mediated targeted drug delivery
    • Zhou, J., and Rossi, J. J. (2011). Cell-specific aptamer-mediated targeted drug delivery. Oligonucleotides 21, 1-10.
    • (2011) Oligonucleotides , vol.21 , pp. 1-10
    • Zhou, J.1    Rossi, J.J.2


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