메뉴 건너뛰기




Volumn 8, Issue 1, 2014, Pages

Towards an integrated systems-based modelling framework for drug transport and its effect on tumour cells

Author keywords

Drug effect; Drug transport; in silico experimental platform; Intracellular signalling; Systems based modelling framework

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN;

EID: 84892419425     PISSN: None     EISSN: 17541611     Source Type: Journal    
DOI: 10.1186/1754-1611-8-3     Document Type: Article
Times cited : (9)

References (50)
  • 1
    • 44749086924 scopus 로고    scopus 로고
    • Integrating cell-cycle progression, drug penetration and energy metabolism to identify improved cancer therapeutic strategies
    • 10.1016/j.jtbi.2008.02.016, 2517579, 18402980
    • Venkatasubramanian R, Henson MA, Forbes NS. Integrating cell-cycle progression, drug penetration and energy metabolism to identify improved cancer therapeutic strategies. J Theor Biol 2008, 253:98-117. 10.1016/j.jtbi.2008.02.016, 2517579, 18402980.
    • (2008) J Theor Biol , vol.253 , pp. 98-117
    • Venkatasubramanian, R.1    Henson, M.A.2    Forbes, N.S.3
  • 2
    • 33746491709 scopus 로고    scopus 로고
    • Drug penetration in solid tumours
    • 10.1038/nrc1893, 16862189
    • Minchinton AI, Tannock IF. Drug penetration in solid tumours. Nat Rev Cancer 2006, 6:583-592. 10.1038/nrc1893, 16862189.
    • (2006) Nat Rev Cancer , vol.6 , pp. 583-592
    • Minchinton, A.I.1    Tannock, I.F.2
  • 3
    • 35148881028 scopus 로고    scopus 로고
    • Drug resistance and the solid tumor microenvironment
    • 10.1093/jnci/djm135, 17895480
    • Trédan O, Galmarini CM, Patel K, Tannock IF. Drug resistance and the solid tumor microenvironment. J Natl Cancer Inst 2007, 99:1441-1454. 10.1093/jnci/djm135, 17895480.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 1441-1454
    • Trédan, O.1    Galmarini, C.M.2    Patel, K.3    Tannock, I.F.4
  • 4
    • 0025334830 scopus 로고
    • Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy
    • Boucher Y, Baxter LT, Jain RK. Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy. Cancer Res 1990, 50:4478-4484.
    • (1990) Cancer Res , vol.50 , pp. 4478-4484
    • Boucher, Y.1    Baxter, L.T.2    Jain, R.K.3
  • 5
    • 31544444415 scopus 로고    scopus 로고
    • The penetration of anticancer drugs through tumor tissue as a function of cellular adhesion and packing density of tumor cells
    • 10.1158/0008-5472.CAN-05-3077, 16424039
    • Grantab R, Sivananthan S, Tannock IF. The penetration of anticancer drugs through tumor tissue as a function of cellular adhesion and packing density of tumor cells. Cancer Res 2006, 66:1033-1039. 10.1158/0008-5472.CAN-05-3077, 16424039.
    • (2006) Cancer Res , vol.66 , pp. 1033-1039
    • Grantab, R.1    Sivananthan, S.2    Tannock, I.F.3
  • 6
    • 0034193258 scopus 로고    scopus 로고
    • Role of extracellular matrix assembly in interstitial transport in solid tumors
    • Netti PA, Berk DA, Swartz MA, Grodzinsky AJ, Jain RK. Role of extracellular matrix assembly in interstitial transport in solid tumors. Cancer Res 2000, 60:2497-2503.
    • (2000) Cancer Res , vol.60 , pp. 2497-2503
    • Netti, P.A.1    Berk, D.A.2    Swartz, M.A.3    Grodzinsky, A.J.4    Jain, R.K.5
  • 7
    • 74049122828 scopus 로고    scopus 로고
    • Cancer systems biology: a network modeling perspective
    • 10.1093/carcin/bgp261, 2802670, 19861649
    • Kreeger PK, Lauffenburger DA. Cancer systems biology: a network modeling perspective. Carcinogenesis 2010, 31:2-8. 10.1093/carcin/bgp261, 2802670, 19861649.
    • (2010) Carcinogenesis , vol.31 , pp. 2-8
    • Kreeger, P.K.1    Lauffenburger, D.A.2
  • 8
    • 0034630167 scopus 로고    scopus 로고
    • Induction of apoptosis by cancer chemotherapy
    • 10.1006/excr.2000.4838, 10739650
    • Kaufmann SH, Earnshaw WC. Induction of apoptosis by cancer chemotherapy. Exp Cell Res 2000, 256:42-49. 10.1006/excr.2000.4838, 10739650.
    • (2000) Exp Cell Res , vol.256 , pp. 42-49
    • Kaufmann, S.H.1    Earnshaw, W.C.2
  • 9
    • 0028345613 scopus 로고
    • Cell-cycle control and cancer-chemotherapy
    • 10.1002/jcb.240540411, 8014193
    • Kohn KW, Jackman J, Oconnor PM. Cell-cycle control and cancer-chemotherapy. J Cell Biochem 1994, 54:440-452. 10.1002/jcb.240540411, 8014193.
    • (1994) J Cell Biochem , vol.54 , pp. 440-452
    • Kohn, K.W.1    Jackman, J.2    Oconnor, P.M.3
  • 10
    • 0141680424 scopus 로고    scopus 로고
    • Cell signaling and cancer
    • 10.1016/S1535-6108(03)00216-2, 14522250
    • Martin GS. Cell signaling and cancer. Cancer Cell 2003, 4:167-174. 10.1016/S1535-6108(03)00216-2, 14522250.
    • (2003) Cancer Cell , vol.4 , pp. 167-174
    • Martin, G.S.1
  • 11
    • 79959977743 scopus 로고    scopus 로고
    • Dynamic modeling and analysis of cancer cellular network motifs
    • Cloutier M, Wang E. Dynamic modeling and analysis of cancer cellular network motifs. Integr Biol 2011, 3:724-732.
    • (2011) Integr Biol , vol.3 , pp. 724-732
    • Cloutier, M.1    Wang, E.2
  • 12
  • 13
    • 80052931582 scopus 로고    scopus 로고
    • Use of mathematical models to understand anticancer drug delivery and its effect on solid tumors
    • 10.2217/pgs.11.71, 21919608
    • Liu C, Krishnan J, Stebbing J, Xu XY. Use of mathematical models to understand anticancer drug delivery and its effect on solid tumors. Pharmacogenomics 2011, 12:1337-1348. 10.2217/pgs.11.71, 21919608.
    • (2011) Pharmacogenomics , vol.12 , pp. 1337-1348
    • Liu, C.1    Krishnan, J.2    Stebbing, J.3    Xu, X.Y.4
  • 14
    • 0033822142 scopus 로고    scopus 로고
    • A mathematical model for comparison of bolus injection, continuous infusion, and liposomal delivery of doxorubicin to tumor cells
    • 10.1038/sj.neo.7900096, 1550297, 11005567
    • El-Kareh AW, Secomb TW. A mathematical model for comparison of bolus injection, continuous infusion, and liposomal delivery of doxorubicin to tumor cells. Neoplasia 2000, 2:325-338. 10.1038/sj.neo.7900096, 1550297, 11005567.
    • (2000) Neoplasia , vol.2 , pp. 325-338
    • El-Kareh, A.W.1    Secomb, T.W.2
  • 15
    • 0343526851 scopus 로고    scopus 로고
    • Computational model of intracellular pharmacokinetics of paclitaxel
    • Kuh HJ, Jang SH, Wientjes MG, Au JL. Computational model of intracellular pharmacokinetics of paclitaxel. J Pharmacol Exp Ther 2000, 293:761-770.
    • (2000) J Pharmacol Exp Ther , vol.293 , pp. 761-770
    • Kuh, H.J.1    Jang, S.H.2    Wientjes, M.G.3    Au, J.L.4
  • 17
    • 69849096664 scopus 로고    scopus 로고
    • A tumor cord model for doxorubicin delivery and dose optimization in solid tumors
    • 10.1186/1742-4682-6-16, 2736154, 19664243
    • Eikenberry S. A tumor cord model for doxorubicin delivery and dose optimization in solid tumors. Theor Biol Med Model 2009, 6:16. 10.1186/1742-4682-6-16, 2736154, 19664243.
    • (2009) Theor Biol Med Model , vol.6 , pp. 16
    • Eikenberry, S.1
  • 18
    • 80052841941 scopus 로고    scopus 로고
    • A systems approach for tumor pharmacokinetics
    • 10.1371/journal.pone.0024696, 3173470, 21935441
    • Thurber GM, Weissleder R. A systems approach for tumor pharmacokinetics. PLoS One 2011, 6:e24696. 10.1371/journal.pone.0024696, 3173470, 21935441.
    • (2011) PLoS One , vol.6
    • Thurber, G.M.1    Weissleder, R.2
  • 19
    • 0034850727 scopus 로고    scopus 로고
    • Simulation of the delivery of doxorubicin to hepatoma
    • 10.1023/A:1011076110317, 11474779
    • Goh Y-MF, Kong HL, Wang C-H. Simulation of the delivery of doxorubicin to hepatoma. Pharm Res 2001, 18:761-770. 10.1023/A:1011076110317, 11474779.
    • (2001) Pharm Res , vol.18 , pp. 761-770
    • Goh, Y.-M.F.1    Kong, H.L.2    Wang, C.-H.3
  • 20
    • 0037349935 scopus 로고    scopus 로고
    • A mathematical model for cisplatin cellular pharmacodynamics
    • 1502402, 12659689
    • El-Kareh AW, Secomb TW. A mathematical model for cisplatin cellular pharmacodynamics. Neoplasia 2003, 5:161-169. 1502402, 12659689.
    • (2003) Neoplasia , vol.5 , pp. 161-169
    • El-Kareh, A.W.1    Secomb, T.W.2
  • 21
    • 23244457368 scopus 로고    scopus 로고
    • Two-mechanism peak concentration model for cellular pharmacodynamics of Doxorubicin
    • 10.1593/neo.05118, 1501422, 16026650
    • El-Kareh AW, Secomb TW. Two-mechanism peak concentration model for cellular pharmacodynamics of Doxorubicin. Neoplasia 2005, 7:705-713. 10.1593/neo.05118, 1501422, 16026650.
    • (2005) Neoplasia , vol.7 , pp. 705-713
    • El-Kareh, A.W.1    Secomb, T.W.2
  • 22
    • 51249114777 scopus 로고    scopus 로고
    • Cell cycle checkpoint models for cellular pharmacology of paclitaxel and platinum drugs
    • 10.1208/s12248-007-9003-6, 2751448, 18446502
    • El-Kareh AW, Labes RE, Secomb TW. Cell cycle checkpoint models for cellular pharmacology of paclitaxel and platinum drugs. AAPS J 2008, 10:15-34. 10.1208/s12248-007-9003-6, 2751448, 18446502.
    • (2008) AAPS J , vol.10 , pp. 15-34
    • El-Kareh, A.W.1    Labes, R.E.2    Secomb, T.W.3
  • 23
    • 0842282616 scopus 로고    scopus 로고
    • Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents
    • 10.1158/0008-5472.CAN-03-2524, 14871843
    • Simeoni M, Magni P, Cammia C, De Nicolao G, Croci V, Pesenti E, Germani M, Poggesi I, Rocchetti M. Predictive pharmacokinetic-pharmacodynamic modeling of tumor growth kinetics in xenograft models after administration of anticancer agents. Cancer Res 2004, 64:1094-1101. 10.1158/0008-5472.CAN-03-2524, 14871843.
    • (2004) Cancer Res , vol.64 , pp. 1094-1101
    • Simeoni, M.1    Magni, P.2    Cammia, C.3    De Nicolao, G.4    Croci, V.5    Pesenti, E.6    Germani, M.7    Poggesi, I.8    Rocchetti, M.9
  • 24
    • 0035082998 scopus 로고    scopus 로고
    • A mathematical model of in vitro cancer cell growth and treatment with the antimitotic agent curacin A
    • 10.1016/S0025-5564(00)00065-1, 11259801
    • Kozusko F, Chen P, Grant SG, Day BW, Panetta JC. A mathematical model of in vitro cancer cell growth and treatment with the antimitotic agent curacin A. Math Biosci 2001, 170:1-16. 10.1016/S0025-5564(00)00065-1, 11259801.
    • (2001) Math Biosci , vol.170 , pp. 1-16
    • Kozusko, F.1    Chen, P.2    Grant, S.G.3    Day, B.W.4    Panetta, J.C.5
  • 25
    • 0037219540 scopus 로고    scopus 로고
    • Intracellular accumulation and mechanism of action of doxorubicin in a spatio-temporal tumor model
    • 10.1006/jtbi.2003.3156, 12468292
    • Jackson TL. Intracellular accumulation and mechanism of action of doxorubicin in a spatio-temporal tumor model. J Theor Biol 2003, 220:201-213. 10.1006/jtbi.2003.3156, 12468292.
    • (2003) J Theor Biol , vol.220 , pp. 201-213
    • Jackson, T.L.1
  • 26
    • 0035126527 scopus 로고    scopus 로고
    • Enhancement of paclitaxel delivery to solid tumors by apoptosis-inducing pretreatment: effect of treatment schedule
    • Jang SH, Wientjes MG, Au JL. Enhancement of paclitaxel delivery to solid tumors by apoptosis-inducing pretreatment: effect of treatment schedule. J Pharmacol Exp Ther 2001, 296:1035-1042.
    • (2001) J Pharmacol Exp Ther , vol.296 , pp. 1035-1042
    • Jang, S.H.1    Wientjes, M.G.2    Au, J.L.3
  • 27
    • 52549112979 scopus 로고    scopus 로고
    • Time- and concentration-dependent penetration of doxorubicin in prostate tumors
    • 10.1208/ps030318, 2779556, 11741266
    • Zheng JH, Chen CT, Au JL, Wientjes MG. Time- and concentration-dependent penetration of doxorubicin in prostate tumors. AAPS PharmSci 2001, 3:E15. 10.1208/ps030318, 2779556, 11741266.
    • (2001) AAPS PharmSci , vol.3
    • Zheng, J.H.1    Chen, C.T.2    Au, J.L.3    Wientjes, M.G.4
  • 28
    • 0024584819 scopus 로고
    • Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection
    • 10.1016/0026-2862(89)90074-5, 2646512
    • Baxter LT, Jain RK. Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection. Microvasc Res 1989, 37:77-104. 10.1016/0026-2862(89)90074-5, 2646512.
    • (1989) Microvasc Res , vol.37 , pp. 77-104
    • Baxter, L.T.1    Jain, R.K.2
  • 29
    • 0025065107 scopus 로고
    • Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics
    • 10.1016/0026-2862(90)90023-K, 2250603
    • Baxter LT, Jain RK. Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics. Microvasc Res 1990, 40:246-263. 10.1016/0026-2862(90)90023-K, 2250603.
    • (1990) Microvasc Res , vol.40 , pp. 246-263
    • Baxter, L.T.1    Jain, R.K.2
  • 30
    • 0025869933 scopus 로고
    • Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism
    • 10.1016/0026-2862(91)90003-T, 2051954
    • Baxter LT, Jain RK. Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism. Microvasc Res 1991, 41:5-23. 10.1016/0026-2862(91)90003-T, 2051954.
    • (1991) Microvasc Res , vol.41 , pp. 5-23
    • Baxter, L.T.1    Jain, R.K.2
  • 31
    • 20344394143 scopus 로고    scopus 로고
    • Transient interstitial fluid flow in brain tumors: effect on drug delivery
    • Teo CS, Hor Keong Tan W, Lee T, Wang C-H. Transient interstitial fluid flow in brain tumors: effect on drug delivery. Chem Eng Sci 2005, 60:4803-4821.
    • (2005) Chem Eng Sci , vol.60 , pp. 4803-4821
    • Teo, C.S.1    Hor Keong Tan, W.2    Lee, T.3    Wang, C.-H.4
  • 32
    • 0030200835 scopus 로고    scopus 로고
    • Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity
    • 10.1006/mvre.1996.0041, 8812751
    • Netti PA, Roberge S, Boucher Y, Baxter LT, Jain RK. Effect of transvascular fluid exchange on pressure-flow relationship in tumors: a proposed mechanism for tumor blood flow heterogeneity. Microvasc Res 1996, 52:27-46. 10.1006/mvre.1996.0041, 8812751.
    • (1996) Microvasc Res , vol.52 , pp. 27-46
    • Netti, P.A.1    Roberge, S.2    Boucher, Y.3    Baxter, L.T.4    Jain, R.K.5
  • 33
    • 0037226277 scopus 로고    scopus 로고
    • A model of fluid flow in solid tumors
    • Pozrikidis C, Farrow DA. A model of fluid flow in solid tumors. Ann Biomed Eng 2003, 31:181-194.
    • (2003) Ann Biomed Eng , vol.31 , pp. 181-194
    • Pozrikidis, C.1    Farrow, D.A.2
  • 34
    • 82755190457 scopus 로고    scopus 로고
    • A systems-based mathematical modelling framework for investigating the effect of drugs on solid tumours
    • 10.1186/1742-4682-8-45, 3261817, 22152406
    • Liu C, Krishnan J, Xu XY. A systems-based mathematical modelling framework for investigating the effect of drugs on solid tumours. Theor Biol Med Model 2011, 8:45. 10.1186/1742-4682-8-45, 3261817, 22152406.
    • (2011) Theor Biol Med Model , vol.8 , pp. 45
    • Liu, C.1    Krishnan, J.2    Xu, X.Y.3
  • 35
    • 0023909330 scopus 로고
    • Determinants of tumor blood flow: a review
    • Jain RK. Determinants of tumor blood flow: a review. Cancer Res 1988, 48:2641-2658.
    • (1988) Cancer Res , vol.48 , pp. 2641-2658
    • Jain, R.K.1
  • 36
    • 0029898758 scopus 로고    scopus 로고
    • Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model
    • 10.1006/mvre.1996.0031, 8992232
    • Baish JW, Gazit Y, Berk DA, Nozue M, Baxter LT, Jain RK. Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model. Microvasc Res 1996, 51:327-346. 10.1006/mvre.1996.0031, 8992232.
    • (1996) Microvasc Res , vol.51 , pp. 327-346
    • Baish, J.W.1    Gazit, Y.2    Berk, D.A.3    Nozue, M.4    Baxter, L.T.5    Jain, R.K.6
  • 37
    • 0018962779 scopus 로고
    • Microcirculatory studies in rat mammary carcinoma. I. Transparent chamber method, development of microvasculature, and pressures in tumor vessels
    • Peters W, Teixeira M, Intaglietta M, Gross JF. Microcirculatory studies in rat mammary carcinoma. I. Transparent chamber method, development of microvasculature, and pressures in tumor vessels. J Natl Cancer Inst 1980, 65:631-642.
    • (1980) J Natl Cancer Inst , vol.65 , pp. 631-642
    • Peters, W.1    Teixeira, M.2    Intaglietta, M.3    Gross, J.F.4
  • 38
    • 79952593286 scopus 로고    scopus 로고
    • Modular systems approach to understanding the interaction of adaptive and monostable and bistable threshold processes
    • 10.1049/iet-syb.2009.0061, 21405196
    • Seaton D, Krishnan J. Modular systems approach to understanding the interaction of adaptive and monostable and bistable threshold processes. IET Syst Biol 2011, 5:81-94. 10.1049/iet-syb.2009.0061, 21405196.
    • (2011) IET Syst Biol , vol.5 , pp. 81-94
    • Seaton, D.1    Krishnan, J.2
  • 39
    • 84883829346 scopus 로고    scopus 로고
    • Modeling a snap-action, variable-delay switch controlling extrinsic cell death
    • 2592357, 19053173
    • Albeck JG, Burke JM, Spencer SL, Lauffenburger DA, Sorger PK. Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol 2008, 6:2831-2852. 2592357, 19053173.
    • (2008) PLoS Biol , vol.6 , pp. 2831-2852
    • Albeck, J.G.1    Burke, J.M.2    Spencer, S.L.3    Lauffenburger, D.A.4    Sorger, P.K.5
  • 40
    • 33749370199 scopus 로고    scopus 로고
    • Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability
    • Legewie S, Bluthgen N, Herzel H. Mathematical modeling identifies inhibitors of apoptosis as mediators of positive feedback and bistability. Plos Comput Biol 2006, 2:1061-1073.
    • (2006) Plos Comput Biol , vol.2 , pp. 1061-1073
    • Legewie, S.1    Bluthgen, N.2    Herzel, H.3
  • 41
    • 79959196445 scopus 로고    scopus 로고
    • A trigger model of apoptosis induced by tumor necrosis factor signaling
    • Gu C, Zhang J, Chen Y, Lei J. A trigger model of apoptosis induced by tumor necrosis factor signaling. BMC Syst Biol 2011, 5(Suppl 1):S13.
    • (2011) BMC Syst Biol , vol.5 , Issue.SUPPL 1
    • Gu, C.1    Zhang, J.2    Chen, Y.3    Lei, J.4
  • 42
    • 68949136900 scopus 로고    scopus 로고
    • Computational analysis of dynamical responses to the intrinsic pathway of programmed cell death
    • 10.1016/j.bpj.2009.04.053, 2711321, 19619456
    • Zhang T, Brazhnik P, Tyson J. Computational analysis of dynamical responses to the intrinsic pathway of programmed cell death. Biophys J 2009, 97:415-434. 10.1016/j.bpj.2009.04.053, 2711321, 19619456.
    • (2009) Biophys J , vol.97 , pp. 415-434
    • Zhang, T.1    Brazhnik, P.2    Tyson, J.3
  • 43
    • 4344674786 scopus 로고    scopus 로고
    • Bistability analyses of a caspase activation model for receptor-induced apoptosis
    • 10.1074/jbc.M404893200, 15208304
    • Eissing T, Conzelmann H, Gilles ED, Allgower F, Bullinger E, Scheurich P. Bistability analyses of a caspase activation model for receptor-induced apoptosis. J Biol Chem 2004, 279:36892-36897. 10.1074/jbc.M404893200, 15208304.
    • (2004) J Biol Chem , vol.279 , pp. 36892-36897
    • Eissing, T.1    Conzelmann, H.2    Gilles, E.D.3    Allgower, F.4    Bullinger, E.5    Scheurich, P.6
  • 44
    • 4544246088 scopus 로고    scopus 로고
    • Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis
    • 10.1083/jcb.200404158, 2172102, 15364960
    • Bentele M, Lavrik I, Ulrich M, Stosser S, Heermann DW, Kalthoff H, Krammer PH, Eils R. Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis. J Cell Biol 2004, 166:839-851. 10.1083/jcb.200404158, 2172102, 15364960.
    • (2004) J Cell Biol , vol.166 , pp. 839-851
    • Bentele, M.1    Lavrik, I.2    Ulrich, M.3    Stosser, S.4    Heermann, D.W.5    Kalthoff, H.6    Krammer, P.H.7    Eils, R.8
  • 45
    • 33646124974 scopus 로고    scopus 로고
    • Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores
    • 10.1529/biophysj.105.068122, 1367306, 16339882
    • Bagci EZ, Vodovotz Y, Billiar TR, Ermentrout GB, Bahar I. Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores. Biophys J 2006, 90:1546-1559. 10.1529/biophysj.105.068122, 1367306, 16339882.
    • (2006) Biophys J , vol.90 , pp. 1546-1559
    • Bagci, E.Z.1    Vodovotz, Y.2    Billiar, T.R.3    Ermentrout, G.B.4    Bahar, I.5
  • 46
    • 84892676310 scopus 로고    scopus 로고
    • An investigation of signal transduction and irreversible decision making through monostable and bistable switches
    • Springer Verlag, Kulkarni V, Stan G-B, Raman K, In press
    • Krishnan J, Liu C. An investigation of signal transduction and irreversible decision making through monostable and bistable switches. Systems and Synthetic Biology: A Systematic Approach 2012, Springer Verlag, Kulkarni V, Stan G-B, Raman K, In press.
    • (2012) Systems and Synthetic Biology: A Systematic Approach
    • Krishnan, J.1    Liu, C.2
  • 47
    • 0003716514 scopus 로고
    • SIAM, 3600 Market Street, Floor 6, Philadelphia, PA 19104: Society for Industrial and Applied Mathematics
    • Edelstein-Keshet L. Mathematical Models in Biology 1988, SIAM, 3600 Market Street, Floor 6, Philadelphia, PA 19104: Society for Industrial and Applied Mathematics.
    • (1988) Mathematical Models in Biology
    • Edelstein-Keshet, L.1
  • 48
    • 0022891086 scopus 로고
    • A pharmacokinetic study of adriamycin and 4′epi-adriamycin after simultaneous intra-arterial liver administration
    • Eksborg S, Andersson M, Domellöf L, Lönroth U. A pharmacokinetic study of adriamycin and 4′epi-adriamycin after simultaneous intra-arterial liver administration. Med Oncol Tumor Pharmacother 1986, 3:105-110.
    • (1986) Med Oncol Tumor Pharmacother , vol.3 , pp. 105-110
    • Eksborg, S.1    Andersson, M.2    Domellöf, L.3    Lönroth, U.4
  • 49
    • 0019985743 scopus 로고
    • Pharmacokinetics of adriamycin in patients with breast cancer: correlation between pharmacokinetic parameters and clinical short-term response
    • Robert J. Pharmacokinetics of adriamycin in patients with breast cancer: correlation between pharmacokinetic parameters and clinical short-term response. Eur J Canc Clin Oncol 1982, 18:739-745.
    • (1982) Eur J Canc Clin Oncol , vol.18 , pp. 739-745
    • Robert, J.1
  • 50
    • 0023219734 scopus 로고
    • Transport of molecules in the tumor interstitium: a review
    • Jain RK. Transport of molecules in the tumor interstitium: a review. Cancer Res 1987, 47:3039-3051.
    • (1987) Cancer Res , vol.47 , pp. 3039-3051
    • Jain, R.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.