Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 20, 2013, Pages 7998-8003

  Zhu, Guizhi ^a,b,c   Zheng, Jing ^a,b   Song, Erqun ^b,d   Donovan, Michael ^a   Zhang, Kejing ^b   Liu, Chen ^e   Tan, Weihong ^a,b,c  

^a HUNAN UNIVERSITY   (China)

^b University of Florida ^*  (United States)

^c UNIVERSITY OF FLORIDA   (United States)

^d SOUTHWEST UNIVERSITY   (China)

^e UNIVERSITY OF FLORIDA   (United States)

Author keywords

DNA nanomedicines; In vivo; Self assembly; Targeted anticancer drug delivery

Indexed keywords

APTAMER; DNA; DOXORUBICIN; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG TRANSPORT; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PRIORITY JOURNAL; TARGET CELL; TUMOR XENOGRAFT;

DNA NANOMEDICINES; IN VIVO; SELF-ASSEMBLY; TARGETED ANTICANCER DRUG DELIVERY;

ANIMALS; ANTINEOPLASTIC AGENTS; APTAMERS, NUCLEOTIDE; BIOCOMPATIBLE MATERIALS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; FLOW CYTOMETRY; HUMANS; MICE; MICE, SCID; NANOCOMPOSITES; NANOMEDICINE; NEOPLASMS; PROTEIN BINDING; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84877858909     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1220817110     Document Type: Article

References (37)

1. Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L (2004) Anthracyclines: Molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56(2):185-229. (Pubitemid 38720829)
2. Cardinale D, et al. (2010) Anthracycline-induced cardiomyopathy: Clinical relevance and response to pharmacologic therapy. J Am Coll Cardiol 55(3):213-220.
3. MacKay JA, et al. (2009) Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection. Nat Mater 8(12):993-999.
4. Lammers T, Aime S, Hennink WE, Storm G, Kiessling F (2011) Theranostic nanomedicine. Acc Chem Res 44(10):1029-1038.
5. Seeman NC (2010) Nanomaterials based on DNA. Annu Rev Biochem 79(1):65-87.
6. Bath J, Turberfield AJ (2007) DNA nanomachines. Nat Nanotechnol 2(5):275-284. (Pubitemid 46882966)
7. Pinheiro AV, Han D, Shih WM, Yan H (2011) Challenges and opportunities for structural DNA nanotechnology. Nat Nanotechnol 6(12):763-772.
8. Dirks RM, Pierce NA (2004) Triggered amplification by hybridization chain reaction. Proc Natl Acad Sci USA 101(43):15275-15278. (Pubitemid 39441531)
9. Jiang Q, et al. (2012) DNA origami as a carrier for circumvention of drug resistance. J Am Chem Soc 134(32):13396-13403.
10. Luo D, Saltzman WM (2000) Synthetic DNA delivery systems. Nat Biotechnol 18(1): 33-37. (Pubitemid 30041168)
11. Douglas SM, Bachelet I, Church GM (2012) A logic-gated nanorobot for targeted transport of molecular payloads. Science 335(6070):831-834.
12. Tan W, et al. (2011) Molecular aptamers for drug delivery. Trends Biotechnol 29(12): 634-640.
13. Lee H, et al. (2012) Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nat Nanotechnol 7(6):389-393.
14. Schüller VJ, et al. (2011) Cellular immunostimulation by CpG-sequence-coated DNA origami structures. ACS Nano 5(12):9696-9702.
15. Li J, et al. (2011) Self-assembled multivalent DNA nanostructures for noninvasive intracellular delivery of immunostimulatory CpG oligonucleotides. ACS Nano 5(11): 8783-8789.
16. Tan SJ, Kiatwuthinon P, Roh YH, Kahn JS, Luo D (2011) Engineering nanocarriers for siRNA delivery. Small 7(7):841-856.
17. Chang M, Yang C-S, Huang D-M (2011) Aptamer-conjugated DNA icosahedral nanoparticles as a carrier of doxorubicin for cancer therapy. ACS Nano 5(8):6156-6163.
18. Huang Y-F, et al. (2009) Molecular assembly of an aptamer-drug conjugate for targeted drug delivery to tumor cells. ChemBioChem 10(5):862-868.
19. Keefe AD, Pai S, Ellington A (2010) Aptamers as therapeutics. Nat Rev Drug Discov 9(7):537-550.
20. Bagalkot V, Farokhzad OC, Langer R, Jon S (2006) An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform. Angew Chem Int Ed Engl 45(48):8149-8152. (Pubitemid 44974149)
21. Yang L, et al. (2011) Aptamer-conjugated nanomaterials and their applications. Adv Drug Deliv Rev 63(14-15):1361-1370.
22. Ellington AD, Szostak JW (1990) In vitro selection of RNA molecules that bind specific ligands. Nature 346(6287):818-822.
23. Tuerk C, Gold L (1990) Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249(4968):505-510.
24. Shangguan D, et al. (2006) Aptamers evolved from live cells as effective molecular probes for cancer study. Proc Natl Acad Sci USA 103(32):11838-11843. (Pubitemid 44215773)
25. Sefah K, Shangguan D, Xiong X, O'Donoghue MB, TanW(2010) Development of DNA aptamers using Cell-SELEX. Nat Protoc 5(6):1169-1185.
26. Shi H, et al. (2010) In vivo fluorescence imaging of tumors using molecular aptamers generated by cell-SELEX. Chem Asian J 5(10):2209-2213.
27. Meng L, et al. (2012) Targeted delivery of chemotherapy agents using a liver cancerspecific aptamer. PLoS One 7(4):e33434.
28. Luo Y-L, Shiao Y-S, Huang Y-F (2011) Release of photoactivatable drugs from plasmonic nanoparticles for targeted cancer therapy. ACS Nano 5(10):7796-7804.
29. Ruggiero A, et al. (2010) Paradoxical glomerular filtration of carbon nanotubes. Proc Natl Acad Sci USA 107(27):12369-12374.
30. Venkataraman S, Dirks RM, Ueda CT, Pierce NA (2010) Selective cell death mediated by small conditional RNAs. Proc Natl Acad Sci USA 107(39):16777-16782.
31. Choi HMT, et al. (2010) Programmable in situ amplification for multiplexed imaging of mRNA expression. Nat Biotechnol 28(11):1208-1212.
32. Wang F, Elbaz J, Orbach R, Magen N, Willner I (2011) Amplified analysis of DNA by the autonomous assembly of polymers consisting of DNAzyme wires. J Am Chem Soc 133(43):17149-17151.
33. Shangguan D, et al. (2008) Cell-specific aptamer probes for membrane protein elucidation in cancer cells. J Proteome Res 7(5):2133-2139.
34. Ireson CR, Kelland LR (2006) Discovery and development of anticancer aptamers. Mol Cancer Ther 5(12):2957-2962. (Pubitemid 46092036)
35. Xiao Z, Shangguan D, Cao Z, Fang X, Tan W (2008) Cell-specific internalization study of an aptamer from whole cell selection. Chemistry 14(6):1769-1775.
36. Zhu G, et al. (2012) Self-assembled aptamer-based drug carriers for bispecific cytotoxicity to cancer cells. Chem Asian J 7(7):1630-1636.
37. Geng Y, et al. (2007) Shape effects of filaments versus spherical particles in flow and drug delivery. Nat Nanotechnol 2(4):249-255. (Pubitemid 46739812)