Aptamer-based nanoparticles for cancer targeting

Journal of Drug Targeting

Volumn 21, Issue 5, 2013, Pages 427-434

  Sá, Lucas Torres Miranda ^a   Simmons, Suzanne ^b   Missailidis, Sotiris ^c   Silva, Maria Isabel Pais Da ^a   Santos Oliveira, Ralph ^d  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b OPEN UNIVERSITY   (United Kingdom)

^c INSTITUTO OSWALDO CRUZ   (Brazil)

^d Nuclear Engineering Institute   (Brazil)

Author keywords

Biodistribution; Cancer; Cancer targeting; Controlled drug delivery; Controlled release; Radio labeling

Indexed keywords

APTAMER; DOXORUBICIN; MUCIN 1; NANOPARTICLE; SILICON DIOXIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG TARGETING; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; ISOTOPE LABELING; MOLECULAR MODEL; MOLECULAR STABILITY; MOUSE; NONHUMAN; PARTICLE SIZE; POROSITY; PRIORITY JOURNAL; RADIOACTIVITY; SCANNING ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE; X RAY DIFFRACTION;

ANIMALS; APTAMERS, PEPTIDE; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; HUMANS; MICE; MUCIN-1; NANOPARTICLES; NEOPLASMS; PARTICLE SIZE; POROSITY; SELEX APTAMER TECHNIQUE; SILICON DIOXIDE; TISSUE DISTRIBUTION; TUMOR MARKERS, BIOLOGICAL;

EID: 84878538160     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/1061186X.2012.761222     Document Type: Article

References (16)

1. Zhun J, Wang H, Liao L, et al. Small mesoporous silica nanoparticles as carriers for enhanced photodynamic therapy. Chem Asian J 2011;6:2332-38.
2. Morelli C, Maris P, Sisci D, et al. Peglated mesoporous silica nanoparticles exclusively target cancer cells. Nanoscale 2011;3: 3198-207.
3. Lu J, Li Z, Zink J, Tamanoi F. In vivo tumor suppression efficacy of mesoporous silica nanoparticles-based drug-delivery system: enhanced efficacy by folate modification. Nanomedicine 2012;8: 212-20.
4. Ozalp VC, Eyidogan F, Oktem HA. Aptamer-gated nanoparticles for smart drug delivery. Pharmaceuticals 2012;4:1137-57.
5. Lu J, Liong M, Zink JI, Tamanoi F. Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs. Small 2007;3:1341-6.
6. Ambrogio MW, Thomas CR, Zhao YL, et al. Mechanized silica nanoparticles: a new frontier in theranostic nanomedicine. Acc Chem Res 2011;44:903-13.
7. Borbas KE, Ferreira CSM, Perkins A, et al. Design and synthesis of mono- and multimeric targeted radiopharmaceuticals based on novel cyclen ligands coupled to anti-MUC1 aptamers for the diagnostic imaging and targeted radiotherapy of cancer. J Bioconjug Chem 2007;18:1205-12.
8. Min K, Jo H, Song K, et al. Dual-aptamer-based delivery vehicle of doxorubicin to both PSMA () and PSMA (-) prostate cancers. Biomaterials 2011;32:2124-32.
9. Missailidis S, Perkins A. Aptamers as novel radiopharmaceuticals: their applications and future prospects in diagnosis and therapy. Cancer Biother Radiopharm 2007;22:453-68.
10. Ferreira CSM, Cheung MC, Missailidis S, et al. Phototoxic aptamers selectively enter and kill epithelial cancer cells. Nucleic Acids Res 2009;37:866-76.
11. Ferreira CSM, Papamichael K, Guilbault G, et al. DNA aptamers against MUC1: Design of aptamer-antibody sandwich ELISA for early tumour diagnosis. Anal Bioanal Chem 2008;390: 1039-50.
12. DaPieve C, Perkins AC, Missailidis S. Anti-MUC1 aptamers: radiolabelling with 99m Tc and biodistribution in MCF-7 tumourbearing mice. Nucl Med Biol 2009;36:703-10.
13. Leite Diniz C, Da Pieve C, Perkins A, et al. Pharmacokinetic and biodistribution studies of anti MUC1 PEGylated aptamers with potential in the targeted radiotherapy of breast cancer. EJC Suppl 2010;85:59-60.
14. Sa LT, Albernaz Mde S, Patricio BF, et al. Biodistribution of nanoparticle: initial considerations. J Pharm Biomed Anal 2012;70:602-4.
15. Perkins A, Missailidis S. Radiolabelled aptamers for tumour imaging and therapy. Q J Nucl Med Mol Imaging 2007;51:292-6.
16. Kim D, Jeong YY, Jon S. A drug-loaded aptamer-gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer. ACS Nano 2010;4:3689-96.