Targeting Id1 and Id3 by a specific peptide aptamer induces E-box promoter activity, cell cycle arrest, and apoptosis in breast cancer cells

Breast Cancer Research and Treatment

Volumn 124, Issue 3, 2010, Pages 623-633

  Mern, Demissew S ^a   Hoppe Seyler, Karin ^a   Hoppe Seyler, Felix ^a   Hasskarl, Jens ^b   Burwinkel, Barbara ^a,c  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Apoptosis; Breast cancer; Cell cycle arrest; Id1 and Id3; Peptide aptamer

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; INHIBITOR OF DIFFERENTIATION 1; INHIBITOR OF DIFFERENTIATION 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PEPTIDE APTAMER; PEPTIDE APTAMER ID 1 3 PA7; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL CYCLE ARREST; CELL STRAIN MCF 7; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIMERIZATION; E BOX ELEMENT; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APTAMERS, PEPTIDE; BREAST NEOPLASMS; CELL CYCLE; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOSE-RESPONSE RELATIONSHIP, DRUG; E-BOX ELEMENTS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; INHIBITOR OF DIFFERENTIATION PROTEIN 1; INHIBITOR OF DIFFERENTIATION PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEOPLASM PROTEINS; POLY(ADP-RIBOSE) POLYMERASES; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; TRANSCRIPTION FACTOR 3; TRANSFECTION; TWO-HYBRID SYSTEM TECHNIQUES; UP-REGULATION;

EID: 78649324266     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-0810-6     Document Type: Article

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