Single walled carbon nanotubes as drug delivery vehicles: Targeting doxorubicin to tumors

Biomaterials

Volumn 33, Issue 6, 2012, Pages 1689-1698

  Meng, Lingjie ^a   Zhang, Xiaoke ^a   Lu, Qinghua ^a   Fei, Zhaofu ^b   Dyson, Paul J ^b  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b EPFL   (Switzerland)

Author keywords

Doxorubicin (DOX); Drug delivery; Polysaccharides; Single walled carbon nanotubes (SWNTs)

Indexed keywords

BIODISTRIBUTIONS; BIOLOGICAL SAFETY; CANCER DIAGNOSTICS; CANCER-TARGETING; CELLULAR UPTAKE; DELIVERY VEHICLE; DOXORUBICIN; DRUG DELIVERY SYSTEM; DRUG DELIVERY VEHICLES; IN-VITRO; PH-DEPENDENT; PHOTO-THERMAL; PHYSICOCHEMICAL PROPERTY; SINGLE-WALLED CARBON; SURFACE FUNCTIONALIZATION; THERAPEUTIC PROPERTIES;

CARBON; CELL MEMBRANES; CHEMOTHERAPY; CYTOLOGY; DISEASES; DRUG DELIVERY; POLYSACCHARIDES; UNLOADING;

SINGLE-WALLED CARBON NANOTUBES (SWCN);

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; DOXORUBICIN; MACROGOL; SINGLE WALLED NANOTUBE; SODIUM CHLORIDE;

ARTICLE; BIOSAFETY; CELL ASSAY; CELL PROLIFERATION; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG PURITY; DRUG TARGETING; DRUG UPTAKE; ENDOCYTOSIS; GRANULOMA; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LUNG FIBROSIS; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TUMOR; TUMOR CELL;

ACOUSTICS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FLUORESCENT DYES; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MATERIALS TESTING; NANOTECHNOLOGY; NANOTUBES, CARBON; POLYSACCHARIDES; SEMICONDUCTORS; SPECTRUM ANALYSIS, RAMAN; SURFACE PROPERTIES;

EID: 83555177197     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.11.004     Document Type: Article

References (63)

1. Wong H.L., Bendayan R., Rauth A.M., Li Y.Q., Wu X.Y. Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Adv Drug Deliv Rev 2007, 59:491-504.
2. Carvalho C., Santos R.X., Cardoso S., Correia S., Oliveira P.J., Santos M.S., et al. Doxorubicin: the good, the bad and the ugly effect. Curr Med Chem 2009, 16:3267-3285.
3. Matsumura Y., Maeda H. A new concept for macromolecular therapeutics in cancer-chemotherapy- mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986, 46:6387-6392.
4. Peer D., Karp J.M., Hong S., FaroKhzad O.C., Margalit R., Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2007, 2:751-760.
5. Moghimi S.M., Hunter A.C., Murray J.C. Nanomedicine: current status and future prospects. Faseb J 2005, 19:311-330.
6. Youns M., Hoheisel J.D., Efferth T. Therapeutic and diagnostic applications of nanoparticles. Curr Drug Targets 2011, 12:357-365.
7. Endo M., Strano M.S., Ajayan P.M. Potential applications of carbon nanotubes. Carbon nanotubes advanced topics in the synthesis, structure, properties and applications 2008, pp. 13-61.
8. Foldvari M., Bagonluri M. Carbon nanotubes as functional excipients for nanomedicines: II. Drug delivery and biocompatibility issues. Nanomed Nanotechnol 2008, 4:183-200.
9. Liang F., Chen B. A review on biomedical applications of single-walled carbon nanotubes. Curr Med Chem 2010, 17:10-24.
10. Iijima S., Ichihashi T. Single-shell carbon nanotubes of 1-nm diameter. Nature 1993, 363:603-605.
11. Bethune D.S., Kiang C.H., Devries M.S., Gorman G., Savoy R., Vazquez J., et al. Cobalt-catalyzed growth of carbon nanotubes with single-atomic-layer walls. Nature 1993, 363:605-607.
12. Iijima S. Helical microtubules of graphitic carbon. Nature 1991, 354:56-58.
13. Saito R., Fujita M., Dresselhaus G., Dresselhaus M.S. Electronic-structure of chiral graphene tubules. Appl Phys Lett 1992, 60:2204-2206.
14. Carlson L.J., Krauss T.D. Photophysics of individual single-walled carbon nanotubes. Acc Chem Res 2008, 41:235-243.
15. Ji S.R., Liu C., Zhang B., Yang F., Xu J., Long J.A., et al. Carbon nanotubes in cancer diagnosis and therapy. BBA-Rev Cancer 2010, 1806:29-35.
16. Liu Z., Sun X., Nakayama-Ratchford N., Dai H. Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery. Acs Nano 2007, 1:50-56.
17. Zhang X.K., Meng L.J., Lu Q.H., Fei Z.F., Dyson P.J. Targeted delivery and controlled release of doxorubicin to cancer cells using modified single wall carbon nanotubes. Biomaterials 2009, 30:6041-6047.
18. Murakami T., Sawada H., Tamura G., Yudasaka M., Iijima S., Tsuchida K. Water-dispersed single-wall carbon nanohorns as drug carriers for local cancer chemotherapy. Nanomedicine (London, England) 2008, 3:453-463.
19. Kostarelos K., Bianco A., Prato M. Promises, facts and challenges for carbon nanotubes in imaging and therapeutics. Nat Nanotechnol 2009, 4:627-633.
20. Prato M., Kostarelos K., Bianco A. Functionalized carbon nanotubes in drug design and discovery. Acc Chem Res 2008, 41:60-68.
21. Bianco A., Kostarelos K., Prato M. Applications of carbon nanotubes in drug delivery. Curr Opin Chem Biol 2005, 9:674-679.
22. Li S.S., He H., Jiao Q.C., Chuong P.H. Applications of carbon nanotubes in drug and gene delivery. Prog Chem 2008, 20:1798-1803.
23. Lacerda L., Bianco A., Prato M., Kostarelos K. Carbon nanotube cell translocation and delivery of nucleic acids in vitro and in vivo. J Mater Chem 2008, 18:17-22.
24. Liu Z., Tabakman S., Welsher K., Dai H.J. Carbon nanotubes in biology and medicine: in vitro and in vivo detection, imaging and drug delivery. Nano Res 2009, 2:85-120.
25. Jain P.K., El-Sayed I.H., El-Sayed M.A. Au nanoparticles target cancer. Nano Today 2007, 2:18-29.
26. Fisher J.W., Sarkar S., Buchanan C.F., Szot C.S., Whitney J., Hatcher H.C., et al. Photothermal response of human and murine cancer cells to multiwalled carbon nanotubes after laser irradiation. Cancer Res 2010, 70:9855-9864.
27. Liu X.W., Tao H.Q., Yang K., Zhang S.A., Lee S.T., Liu Z.A. Optimization of surface chemistry on single-walled carbon nanotubes for in vivo photothermal ablation of tumors. Biomaterials 2011, 32:144-151.
28. Levi-Polyachenko N.H., Merkel E.J., Jones B.T., Carroll D.L., Stewart J.H. Rapid photothermal intracellular drug delivery using multiwalled carbon nanotubes. Mol Pharm 2009, 6:1092-1099.
29. Welsher K., Liu Z., Daranciang D., Dai H. Selective probing and imaging of cells with single walled carbon nanotubes as near-infrared fluorescent molecules. Nano Lett 2008, 8:586-590.
30. Liu Z.A., Li X.L., Tabakman S.M., Jiang K.L., Fan S.S., Dai H.J. Multiplexed multicolor Raman imaging of live cells with isotopically modified single walled carbon nanotubes. J Am Chem Soc 2008, 130:13540-13541.
31. Hadjiev V.G., Arepalli S., Nikolaev P., Jandl S., Yowell L. Enhanced Raman microprobe imaging of single-wall carbon nanotubes. Nanotechnology 2004, 15:562-567.
32. Hyoung Won B., Ok J.G., Hui Joon P., Tao L., Sung-Liang C., Hart A.J., et al. Carbon nanotube composite optoacoustic transmitters for strong and high frequency ultrasound generation. Appl Phys Lett 2010, 234104-234107.
33. de la Zerda A., Liu Z.A., Bodapati S., Teed R., Vaithilingam S., Khuri-Yakub B.T., et al. Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice. Nano Lett 2010, 10:2168-2172.
34. Poland C.A., Duffin R., Kinloch I., Maynard A., Wallace W.A.H., Seaton A., et al. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol 2008, 3:423-428.
35. Takagi A., Hirose A., Nishimura T., Fukumori N., Ogata A., Ohashi N., et al. Induction of mesothelioma in p53+/- mouse by intraperitoneal application of multi-wall carbon nanotube. J Toxicol Sci 2008, 33:105-116.
36. Hussain M.A., Kabir M.A., Sood A.K. On the cytotoxicity of carbon nanotubes. Curr Sci 2009, 96:664-673.
37. Lacerda L., Bianco A., Prato M., Kostarelos K. Carbon nanotubes as nanomedicines: from toxicology to pharmacology. Adv Drug Deliv Rev 2006, 58:1460-1470.
38. Kostarelos K., Lacerda L., Pastorin G., Wu W., Wieckowski S., Luangsivilay J., et al. Cellular uptake of functionalized carbon nanotubes is independent of functional group and cell type. Nat Nanotechnol 2007, 2:108-113.
39. Dumortier H., Lacotte S., Pastorin G., Marega R., Wu W., Bonifazi D., et al. Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells. Nano Lett 2006, 6:1522-1528.
40. Raja P.M.V., Connolley J., Ganesan G.P., Ci L.J., Ajayan P.M., Nalamasu O., et al. Impact of carbon nanotube exposure, dosage and aggregation on smooth muscle cells. Toxicol Lett 2007, 169:51-63.
41. Kostarelos K. The long and short of carbon nanotube toxicity. Nat Biotechnol 2008, 26:774-776.
42. Belyanskaya L., Manser P., Spohn P., Bruinink A., Wick P. The reliability and limits of the MTT reduction assay for carbon nanotubes-cell interaction. Carbon 2007, 45:2643-2648.
43. Zhang X.K., Meng L.J., Wang X.F., Lu Q.H. Preparation and cellular uptake of pH-dependent fluorescent single-wall carbon nanotubes. Chem Eur J 2010, 16:556-561.
44. Zhang X.K., Wang X.F., Lu Q.H., Fu C.L. Influence of carbon nanotube scaffolds on human cervical carcinoma HeLa cell viability and focal adhesion kinase expression. Carbon 2008, 46:453-460.
45. Li L., Meng L.J., Zhang X.K., Fu C.L., Lu Q.H. The ionic liquid-associated synthesis of a cellulose/SWCNT complex and its remarkable biocompatibility. J Mater Chem 2009, 19:3612-3617.
46. Becker M.L., Fagan J.A., Gallant N.D., Bauer B.J., Bajpai V., Hobbie E.K., et al. Length-dependent uptake of DNA-wrapped single-walled carbon nanotubes. Adv Mater 2007, 19:939-945.
47. Wick P., Manser P., Limbach L.K., Dettlaff-Weglikowska U., Krumeich F., Roth S., et al. The degree and kind of agglomeration affect carbon nanotube cytotoxicity. Toxicol Lett 2007, 168:121-131.
48. Liu Z., Tabakman S.M., Chen Z., Dai H.J. Preparation of carbon nanotube bioconjugates for biomedical applications. Nat Protoc 2009, 4:1372-1382.
49. Zhang X.K., Meng L.J., Lu Q.H. Cell behaviors on polysaccharide-wrapped single-wall carbon nanotubes: a quantitative study of the surface properties of biomimetic nanofibrous scaffolds. Acs Nano 2009, 3:3200-3206.
50. Sayes C.M., Liang F., Hudson J.L., Mendez J., Guo W.H., Beach J.M., et al. Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro. Toxicol Lett 2006, 161:135-142.
51. Jin H., Heller D.A., Strano M.S. Single-particle tracking of endocytosis and exocytosis of single-walled carbon nanotubes in NIH-3T3 cells. Nano Lett 2008, 8:1577-1585.
52. Shvedova A.A., Kisin E., Murray A.R., Johnson V.J., Gorelik O., Arepalli S., et al. Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis. Am J Physiol Lung Cell Mol Physiol 2008, 295:L552-L565.
53. Shvedova A.A., Kisin E.R., Mercer R., Murray A.R., Johnson V.J., Potapovich A.I., et al. Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 2005, 289:L698-L708.
54. Christian P., Shrestha J., LeClerq S.C., Khatry S.K., Jiang T.N., Wagner T., et al. Supplementation with micronutrients in addition to iron and folic acid does not further improve the hematologic status of pregnant women in rural Nepal. J Nutr 2003, 133:3492-3498.
55. Murakami S., Okubo K., Tsuji Y., Sakata H., Takahashi T., Kikuchi M., et al. Changes in liver enzymes after surgery in anti-hepatitis C virus-positive patients. World J Surg 2004, 28:671-674.
56. Hong S.Y., Tobias G., Al-Jamal K.T., Ballesteros B., Ali-Boucetta H., Lozano-Perez S., et al. Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging. Nat Mater 2010, 9:485-490.
57. Singh R., Pantarotto D., Lacerda L., Pastorin G., Klumpp C., Prato M., et al. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc Natl Acad Sci USA 2006, 103:3357-3362.
58. Lacerda L., Soundararajan A., Singh R., Pastorin G., Al-Jamal K.T., Turton J., et al. Dynamic imaging of functionalized multi-walled carbon nanotube systemic circulation and urinary excretion. Adv Mater 2008, 20:225-230.
59. Liu Z., Davis C., Cai W.B., He L., Chen X.Y., Dai H.J. Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy. Proc Natl Acad Sci USA 2008, 105:1410-1415.
60. Feazell R.P., Nakayama-Ratchford N., Dai H., Lippard S.J. Soluble single-walled carbon nanotubes as longboat delivery systems for Platinum(IV) anticancer drug design. J Am Chem Soc 2007, 129:8438-8439.
61. Liu Z., Fan Alice C., Rakhra K., Sherlock S., Goodwin A., Chen X., et al. Supramolecular stacking of doxorubicin on carbon nanotubes for in vivo cancer therapy. Angew Chem Int Ed 2009, 48:7668-7672.
62. Murakami T., Fan J., Yudasaka M., Iijima S., Shiba K. Solubilization of single-wall carbon nanohorns using a PEG-Doxorubicin conjugate. Mol Pharm 2006, 3:407-414.
63. Ji Z.F., Lin G.F., Lu Q.H., Meng L.J., Shen X.Z., Dong L., et al. Targeted therapy of SMMC-7721 liver cancer invitro and invivo with carbon nanotubes based drug delivery system. J Colloid Interface Sci 2012, 365:143-149.