Discovery and development of the G-rich oligonucleotide AS1411 as a novel treatment for cancer

Experimental and Molecular Pathology

Volumn 86, Issue 3, 2009, Pages 151-164

  Bates, Paula J ^a   Laber, Damian A ^a   Miller, Donald M ^a   Thomas, Shelia D ^a   Trent, John O ^a  

^a UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

Author keywords

Aptamer; AS1411; Dz13; G quartets; G rich oligonucleotides; NF kappaB; Nucleolin; PRMT5; Quadruplex; T oligos

Indexed keywords

AGRO 100; ANTINEOPLASTIC AGENT; APTAMER; AS 1411; CYTARABINE; GUANINE; MONOCLONAL ANTIBODY; NUCLEOLIN; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; CANCER CELL; CANCER THERAPY; CELL SURFACE; CLINICAL TRIAL; CONTINUOUS INFUSION; DRUG DOSE ESCALATION; DRUG MECHANISM; HUMAN; KIDNEY CARCINOMA; LUNG NON SMALL CELL CANCER; MONOTHERAPY; MULTIPLE CYCLE TREATMENT; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN TARGETING; REVIEW; SINGLE DRUG DOSE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CLINICAL TRIALS AS TOPIC; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; NEOPLASMS; OLIGODEOXYRIBONUCLEOTIDES; PHOSPHOPROTEINS; RNA-BINDING PROTEINS;

EID: 67349167635     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2009.01.004     Document Type: Review

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