메뉴 건너뛰기




Volumn 7, Issue 2, 2012, Pages

A heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesis

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; MATRIX METALLOPROTEINASE 14; ANGIOGENESIS INHIBITOR; SIGNAL PEPTIDE;

EID: 84857422770     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030753     Document Type: Article
Times cited : (117)

References (65)
  • 1
    • 33645739790 scopus 로고    scopus 로고
    • Tumor stroma and regulation of cancer development
    • Tlsty TD, Coussens LM, (2006) Tumor stroma and regulation of cancer development. Annu Rev Pathol 1: 119-150.
    • (2006) Annu Rev Pathol , vol.1 , pp. 119-150
    • Tlsty, T.D.1    Coussens, L.M.2
  • 2
    • 52049101546 scopus 로고    scopus 로고
    • Tumor microenvironment and angiogenesis
    • Nyberg P, Salo T, Kalluri R, (2008) Tumor microenvironment and angiogenesis. Front Biosci 13: 6537-6553.
    • (2008) Front Biosci , vol.13 , pp. 6537-6553
    • Nyberg, P.1    Salo, T.2    Kalluri, R.3
  • 3
    • 33846531356 scopus 로고    scopus 로고
    • The tumour microenvironment as a target for chemoprevention
    • Albini A, Sporn MB, (2007) The tumour microenvironment as a target for chemoprevention. Nat Rev Cancer 7: 139-147.
    • (2007) Nat Rev Cancer , vol.7 , pp. 139-147
    • Albini, A.1    Sporn, M.B.2
  • 4
    • 8144228952 scopus 로고    scopus 로고
    • Friends or foes - bipolar effects of the tumour stroma in cancer
    • Mueller MM, Fusenig NE, (2004) Friends or foes- bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 4: 839-849.
    • (2004) Nat Rev Cancer , vol.4 , pp. 839-849
    • Mueller, M.M.1    Fusenig, N.E.2
  • 5
    • 0015311426 scopus 로고
    • Anti-angiogenesis: new concept for therapy of solid tumors
    • Folkman J, (1972) Anti-angiogenesis: new concept for therapy of solid tumors. Ann Surg 175: 409-416.
    • (1972) Ann Surg , vol.175 , pp. 409-416
    • Folkman, J.1
  • 6
    • 33748940402 scopus 로고    scopus 로고
    • Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch
    • Naumov GN, Akslen LA, Folkman J, (2006) Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switch. Cell Cycle 5: 1779-1787.
    • (2006) Cell Cycle , vol.5 , pp. 1779-1787
    • Naumov, G.N.1    Akslen, L.A.2    Folkman, J.3
  • 7
    • 33645088428 scopus 로고    scopus 로고
    • Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment
    • Kopfstein L, Christofori G, (2006) Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment. Cell Mol Life Sci 63: 449-468.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 449-468
    • Kopfstein, L.1    Christofori, G.2
  • 8
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers AF, Groom AC, MacDonald IC, (2002) Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2: 563-572.
    • (2002) Nat Rev Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    MacDonald, I.C.3
  • 9
    • 70349782389 scopus 로고    scopus 로고
    • An overview of small-molecule inhibitors of VEGFR signaling
    • Ivy SP, Wick JY, Kaufman BM, (2009) An overview of small-molecule inhibitors of VEGFR signaling. Nat Rev Clin Oncol 6: 569-579.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 569-579
    • Ivy, S.P.1    Wick, J.Y.2    Kaufman, B.M.3
  • 10
    • 33746548452 scopus 로고    scopus 로고
    • Predicting benefit from anti-angiogenic agents in malignancy
    • Jubb AM, Oates AJ, Holden S, Koeppen H, (2006) Predicting benefit from anti-angiogenic agents in malignancy. Nat Rev Cancer 6: 626-635.
    • (2006) Nat Rev Cancer , vol.6 , pp. 626-635
    • Jubb, A.M.1    Oates, A.J.2    Holden, S.3    Koeppen, H.4
  • 11
    • 34249689753 scopus 로고    scopus 로고
    • Molecular regulation of angiogenesis and lymphangiogenesis
    • Adams RH, Alitalo K, (2007) Molecular regulation of angiogenesis and lymphangiogenesis. Nat Rev Mol Cell Biol 8: 464-478.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 464-478
    • Adams, R.H.1    Alitalo, K.2
  • 12
    • 34249744576 scopus 로고    scopus 로고
    • Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells
    • Yana I, Sagara H, Takaki S, Takatsu K, Nakamura K, et al. (2007) Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells. J Cell Sci 120: 1607-1614.
    • (2007) J Cell Sci , vol.120 , pp. 1607-1614
    • Yana, I.1    Sagara, H.2    Takaki, S.3    Takatsu, K.4    Nakamura, K.5
  • 13
    • 0031852566 scopus 로고    scopus 로고
    • Induction of endothelial cell apoptosis by solid tumor cells
    • Kebers F, Lewalle JM, Desreux J, Munaut C, Devy L, et al. (1998) Induction of endothelial cell apoptosis by solid tumor cells. Exp Cell Res 240: 197-205.
    • (1998) Exp Cell Res , vol.240 , pp. 197-205
    • Kebers, F.1    Lewalle, J.M.2    Desreux, J.3    Munaut, C.4    Devy, L.5
  • 14
    • 0024094113 scopus 로고
    • Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures
    • Kubota Y, Kleinman HK, Martin GR, Lawley TJ, (1988) Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures. J Cell Biol 107: 1589-1598.
    • (1988) J Cell Biol , vol.107 , pp. 1589-1598
    • Kubota, Y.1    Kleinman, H.K.2    Martin, G.R.3    Lawley, T.J.4
  • 15
    • 0024358455 scopus 로고
    • Induction of morphologic differentiation of endothelial cells in culture
    • Lawley TJ, Kubota Y, (1989) Induction of morphologic differentiation of endothelial cells in culture. J Invest Dermatol 93: 59S-61S.
    • (1989) J Invest Dermatol , vol.93
    • Lawley, T.J.1    Kubota, Y.2
  • 16
    • 0036712828 scopus 로고    scopus 로고
    • Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs)
    • Lafleur MA, Handsley MM, Knauper V, Murphy G, Edwards DR, (2002) Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs). J Cell Sci 115: 3427-3438.
    • (2002) J Cell Sci , vol.115 , pp. 3427-3438
    • Lafleur, M.A.1    Handsley, M.M.2    Knauper, V.3    Murphy, G.4    Edwards, D.R.5
  • 17
    • 0027197958 scopus 로고
    • Paracrine induction of angiogenesis in vitro by Swiss 3T3 fibroblasts
    • Montesano R, Pepper MS, Orci L, (1993) Paracrine induction of angiogenesis in vitro by Swiss 3T3 fibroblasts. J Cell Sci 105 (Pt 4): 1013-1024.
    • (1993) J Cell Sci , vol.105 , Issue.Pt 4 , pp. 1013-1024
    • Montesano, R.1    Pepper, M.S.2    Orci, L.3
  • 20
    • 33747859659 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer: a novel tumor-promoting cell type
    • Orimo A, Weinberg RA, (2006) Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle 5: 1597-1601.
    • (2006) Cell Cycle , vol.5 , pp. 1597-1601
    • Orimo, A.1    Weinberg, R.A.2
  • 21
    • 33644951882 scopus 로고    scopus 로고
    • Development and characterization of a spheroidal coculture model of endothelial cells and fibroblasts for improving angiogenesis in tissue engineering
    • Wenger A, Kowalewski N, Stahl A, Mehlhorn AT, Schmal H, et al. (2005) Development and characterization of a spheroidal coculture model of endothelial cells and fibroblasts for improving angiogenesis in tissue engineering. Cells Tissues Organs 181: 80-88.
    • (2005) Cells Tissues Organs , vol.181 , pp. 80-88
    • Wenger, A.1    Kowalewski, N.2    Stahl, A.3    Mehlhorn, A.T.4    Schmal, H.5
  • 22
    • 33646421684 scopus 로고    scopus 로고
    • Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro
    • Kunz-Schughart LA, Schroeder JA, Wondrak M, van Rey F, Lehle K, et al. (2006) Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro. Am J Physiol Cell Physiol 290: C1385-1398.
    • (2006) Am J Physiol Cell Physiol , vol.290
    • Kunz-Schughart, L.A.1    Schroeder, J.A.2    Wondrak, M.3    van Rey, F.4    Lehle, K.5
  • 23
    • 48749088453 scopus 로고    scopus 로고
    • Fibroblasts potentiate blood vessel formation partially through secreted factor TIMP-1
    • Liu H, Chen B, Lilly B, (2008) Fibroblasts potentiate blood vessel formation partially through secreted factor TIMP-1. Angiogenesis 11: 223-234.
    • (2008) Angiogenesis , vol.11 , pp. 223-234
    • Liu, H.1    Chen, B.2    Lilly, B.3
  • 24
    • 3042667195 scopus 로고    scopus 로고
    • Three-dimensional in vitro tissue culture models of breast cancer- a review
    • Kim JB, Stein R, O'Hare MJ, (2004) Three-dimensional in vitro tissue culture models of breast cancer- a review. Breast Cancer Res Treat 85: 281-291.
    • (2004) Breast Cancer Res Treat , vol.85 , pp. 281-291
    • Kim, J.B.1    Stein, R.2    O'Hare, M.J.3
  • 25
    • 23744472983 scopus 로고    scopus 로고
    • Gene expression perturbation in vitro-a growing case for three-dimensional (3D) culture systems
    • Birgersdotter A, Sandberg R, Ernberg I, (2005) Gene expression perturbation in vitro-a growing case for three-dimensional (3D) culture systems. Semin Cancer Biol 15: 405-412.
    • (2005) Semin Cancer Biol , vol.15 , pp. 405-412
    • Birgersdotter, A.1    Sandberg, R.2    Ernberg, I.3
  • 26
    • 0031883574 scopus 로고    scopus 로고
    • Multicellular spheroids: a three-dimensional in vitro culture system to study tumour biology
    • Kunz-Schughart LA, Kreutz M, Knuechel R, (1998) Multicellular spheroids: a three-dimensional in vitro culture system to study tumour biology. Int J Exp Pathol 79: 1-23.
    • (1998) Int J Exp Pathol , vol.79 , pp. 1-23
    • Kunz-Schughart, L.A.1    Kreutz, M.2    Knuechel, R.3
  • 27
    • 34648834682 scopus 로고    scopus 로고
    • The third dimension bridges the gap between cell culture and live tissue
    • Pampaloni F, Reynaud EG, Stelzer EH, (2007) The third dimension bridges the gap between cell culture and live tissue. Nat Rev Mol Cell Biol 8: 839-845.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 839-845
    • Pampaloni, F.1    Reynaud, E.G.2    Stelzer, E.H.3
  • 28
    • 0032583125 scopus 로고    scopus 로고
    • Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation
    • Korff T, Augustin HG, (1998) Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation. J Cell Biol 143: 1341-1352.
    • (1998) J Cell Biol , vol.143 , pp. 1341-1352
    • Korff, T.1    Augustin, H.G.2
  • 29
    • 0035121532 scopus 로고    scopus 로고
    • Blood vessel maturation in a 3-dimensional spheroidal coculture model: direct contact with smooth muscle cells regulates endothelial cell quiescence and abrogates VEGF responsiveness
    • Korff T, Kimmina S, Martiny-Baron G, Augustin HG, (2001) Blood vessel maturation in a 3-dimensional spheroidal coculture model: direct contact with smooth muscle cells regulates endothelial cell quiescence and abrogates VEGF responsiveness. FASEB J 15: 447-457.
    • (2001) FASEB J , vol.15 , pp. 447-457
    • Korff, T.1    Kimmina, S.2    Martiny-Baron, G.3    Augustin, H.G.4
  • 30
    • 0032498114 scopus 로고    scopus 로고
    • MT1-MMP on the cell surface causes focal degradation of gelatin films
    • d'Ortho MP, Stanton H, Butler M, Atkinson SJ, Murphy G, et al. (1998) MT1-MMP on the cell surface causes focal degradation of gelatin films. FEBS Lett 421: 159-164.
    • (1998) FEBS Lett , vol.421 , pp. 159-164
    • d'Ortho, M.P.1    Stanton, H.2    Butler, M.3    Atkinson, S.J.4    Murphy, G.5
  • 31
    • 0141745162 scopus 로고    scopus 로고
    • Myofibroblasts enable invasion of endothelial cells into three-dimensional tumor cell clusters: a novel in vitro tumor model
    • Walter-Yohrling J, Pratt BM, Ledbetter S, Teicher BA, (2003) Myofibroblasts enable invasion of endothelial cells into three-dimensional tumor cell clusters: a novel in vitro tumor model. Cancer Chemother Pharmacol 52: 263-269.
    • (2003) Cancer Chemother Pharmacol , vol.52 , pp. 263-269
    • Walter-Yohrling, J.1    Pratt, B.M.2    Ledbetter, S.3    Teicher, B.A.4
  • 32
    • 0042121208 scopus 로고    scopus 로고
    • Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1
    • Nakatsu MN, Sainson RC, Aoto JN, Taylor KL, Aitkenhead M, et al. (2003) Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1. Microvasc Res 66: 102-112.
    • (2003) Microvasc Res , vol.66 , pp. 102-112
    • Nakatsu, M.N.1    Sainson, R.C.2    Aoto, J.N.3    Taylor, K.L.4    Aitkenhead, M.5
  • 33
    • 61949143520 scopus 로고    scopus 로고
    • NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1
    • Liu H, Kennard S, Lilly B, (2009) NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1. Circ Res 104: 466-475.
    • (2009) Circ Res , vol.104 , pp. 466-475
    • Liu, H.1    Kennard, S.2    Lilly, B.3
  • 34
    • 78149312718 scopus 로고    scopus 로고
    • Reversible transdifferentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro
    • Cooley LS, Handsley MM, Zhou Z, Lafleur MA, Pennington CJ, et al. (2010) Reversible transdifferentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro. J Cell Sci 123: 3808-3816.
    • (2010) J Cell Sci , vol.123 , pp. 3808-3816
    • Cooley, L.S.1    Handsley, M.M.2    Zhou, Z.3    Lafleur, M.A.4    Pennington, C.J.5
  • 35
    • 61349168351 scopus 로고    scopus 로고
    • A mechanosensitive transcriptional mechanism that controls angiogenesis
    • Mammoto A, Connor KM, Mammoto T, Yung CW, Huh D, et al. (2009) A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature 457: 1103-1108.
    • (2009) Nature , vol.457 , pp. 1103-1108
    • Mammoto, A.1    Connor, K.M.2    Mammoto, T.3    Yung, C.W.4    Huh, D.5
  • 36
    • 0022972814 scopus 로고
    • Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis
    • Chiquet-Ehrismann R, Mackie EJ, Pearson CA, Sakakura T, (1986) Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis. Cell 47: 131-139.
    • (1986) Cell , vol.47 , pp. 131-139
    • Chiquet-Ehrismann, R.1    Mackie, E.J.2    Pearson, C.A.3    Sakakura, T.4
  • 38
    • 0027293886 scopus 로고
    • Laminin production and fibronectin immunoreactivity in breast carcinomas
    • Gorczyca W, Holm R, Nesland JM, (1993) Laminin production and fibronectin immunoreactivity in breast carcinomas. Anticancer Res 13: 851-858.
    • (1993) Anticancer Res , vol.13 , pp. 851-858
    • Gorczyca, W.1    Holm, R.2    Nesland, J.M.3
  • 40
    • 36249022282 scopus 로고    scopus 로고
    • Antiangiogenic agents in breast cancer
    • Salter JT, Miller KD, (2007) Antiangiogenic agents in breast cancer. Cancer Invest 25: 518-526.
    • (2007) Cancer Invest , vol.25 , pp. 518-526
    • Salter, J.T.1    Miller, K.D.2
  • 41
    • 72249119811 scopus 로고    scopus 로고
    • VEGF-A: a critical regulator of blood vessel growth
    • Ferrara N, (2009) VEGF-A: a critical regulator of blood vessel growth. Eur Cytokine Netw 20: 158-163.
    • (2009) Eur Cytokine Netw , vol.20 , pp. 158-163
    • Ferrara, N.1
  • 42
    • 44149090296 scopus 로고    scopus 로고
    • Role of platelet-derived growth factors in physiology and medicine
    • Andrae J, Gallini R, Betsholtz C, (2008) Role of platelet-derived growth factors in physiology and medicine. Genes Dev 22: 1276-1312.
    • (2008) Genes Dev , vol.22 , pp. 1276-1312
    • Andrae, J.1    Gallini, R.2    Betsholtz, C.3
  • 43
    • 0033525530 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues
    • Kendall RL, Rutledge RZ, Mao X, Tebben AJ, Hungate RW, et al. (1999) Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues. J Biol Chem 274: 6453-6460.
    • (1999) J Biol Chem , vol.274 , pp. 6453-6460
    • Kendall, R.L.1    Rutledge, R.Z.2    Mao, X.3    Tebben, A.J.4    Hungate, R.W.5
  • 44
    • 0028091564 scopus 로고
    • Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation
    • Kovalenko M, Gazit A, Bohmer A, Rorsman C, Ronnstrand L, et al. (1994) Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation. Cancer Res 54: 6106-6114.
    • (1994) Cancer Res , vol.54 , pp. 6106-6114
    • Kovalenko, M.1    Gazit, A.2    Bohmer, A.3    Rorsman, C.4    Ronnstrand, L.5
  • 45
    • 30444446821 scopus 로고    scopus 로고
    • Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model
    • Menu E, Jernberg-Wiklund H, Stromberg T, De Raeve H, Girnita L, et al. (2006) Inhibiting the IGF-1 receptor tyrosine kinase with the cyclolignan PPP: an in vitro and in vivo study in the 5T33MM mouse model. Blood 107: 655-660.
    • (2006) Blood , vol.107 , pp. 655-660
    • Menu, E.1    Jernberg-Wiklund, H.2    Stromberg, T.3    De Raeve, H.4    Girnita, L.5
  • 46
    • 0036793827 scopus 로고    scopus 로고
    • Blockade of insulin-like growth factor I receptor function inhibits growth and angiogenesis of colon cancer
    • Reinmuth N, Liu W, Fan F, Jung YD, Ahmad SA, et al. (2002) Blockade of insulin-like growth factor I receptor function inhibits growth and angiogenesis of colon cancer. Clin Cancer Res 8: 3259-3269.
    • (2002) Clin Cancer Res , vol.8 , pp. 3259-3269
    • Reinmuth, N.1    Liu, W.2    Fan, F.3    Jung, Y.D.4    Ahmad, S.A.5
  • 47
    • 84857420247 scopus 로고    scopus 로고
    • Sesamin Inhibits Macrophage-Induced Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 Expression and Proangiogenic Activity in Breast Cancer Cells
    • Lee CC, Liu KJ, Wu YC, Lin SJ, Chang CC, et al. (2010) Sesamin Inhibits Macrophage-Induced Vascular Endothelial Growth Factor and Matrix Metalloproteinase-9 Expression and Proangiogenic Activity in Breast Cancer Cells. Inflammation.
    • (2010) Inflammation
    • Lee, C.C.1    Liu, K.J.2    Wu, Y.C.3    Lin, S.J.4    Chang, C.C.5
  • 48
    • 0037448628 scopus 로고    scopus 로고
    • IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells
    • Freund A, Chauveau C, Brouillet JP, Lucas A, Lacroix M, et al. (2003) IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells. Oncogene 22: 256-265.
    • (2003) Oncogene , vol.22 , pp. 256-265
    • Freund, A.1    Chauveau, C.2    Brouillet, J.P.3    Lucas, A.4    Lacroix, M.5
  • 49
    • 78049374467 scopus 로고    scopus 로고
    • Novel research horizons for presenilins and gamma-secretases in cell biology and disease
    • De Strooper B, Annaert W, (2010) Novel research horizons for presenilins and gamma-secretases in cell biology and disease. Annu Rev Cell Dev Biol 26: 235-260.
    • (2010) Annu Rev Cell Dev Biol , vol.26 , pp. 235-260
    • De Strooper, B.1    Annaert, W.2
  • 50
    • 33847046849 scopus 로고    scopus 로고
    • Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
    • Hellstrom M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, et al. (2007) Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445: 776-780.
    • (2007) Nature , vol.445 , pp. 776-780
    • Hellstrom, M.1    Phng, L.K.2    Hofmann, J.J.3    Wallgard, E.4    Coultas, L.5
  • 51
    • 36849080314 scopus 로고    scopus 로고
    • Matrix metalloproteinases at cancer tumor-host interface
    • Noel A, Jost M, Maquoi E, (2008) Matrix metalloproteinases at cancer tumor-host interface. Semin Cell Dev Biol 19: 52-60.
    • (2008) Semin Cell Dev Biol , vol.19 , pp. 52-60
    • Noel, A.1    Jost, M.2    Maquoi, E.3
  • 52
    • 0027956746 scopus 로고
    • Inhibition of angiogenesis by the matrix metalloprotease inhibitor N-[2R-2-(hydroxamidocarbonymethyl)-4-methylpentanoyl)]-L-tryptophan methylamide
    • Galardy RE, Grobelny D, Foellmer HG, Fernandez LA, (1994) Inhibition of angiogenesis by the matrix metalloprotease inhibitor N-[2R-2-(hydroxamidocarbonymethyl)-4-methylpentanoyl)]-L-tryptophan methylamide. Cancer Res 54: 4715-4718.
    • (1994) Cancer Res , vol.54 , pp. 4715-4718
    • Galardy, R.E.1    Grobelny, D.2    Foellmer, H.G.3    Fernandez, L.A.4
  • 53
    • 44349108396 scopus 로고    scopus 로고
    • Shedding light on an old mystery: thalidomide suppresses survival pathways to induce limb defects
    • Knobloch J, Ruther U, (2008) Shedding light on an old mystery: thalidomide suppresses survival pathways to induce limb defects. Cell Cycle 7: 1121-1127.
    • (2008) Cell Cycle , vol.7 , pp. 1121-1127
    • Knobloch, J.1    Ruther, U.2
  • 54
    • 7044230866 scopus 로고    scopus 로고
    • Thalidomide in solid tumours: the resurrection of an old drug
    • Sleijfer S, Kruit WH, Stoter G, (2004) Thalidomide in solid tumours: the resurrection of an old drug. Eur J Cancer 40: 2377-2382.
    • (2004) Eur J Cancer , vol.40 , pp. 2377-2382
    • Sleijfer, S.1    Kruit, W.H.2    Stoter, G.3
  • 55
    • 0037446897 scopus 로고    scopus 로고
    • Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins
    • Sudhakar A, Sugimoto H, Yang C, Lively J, Zeisberg M, et al. (2003) Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins. Proc Natl Acad Sci U S A 100: 4766-4771.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 4766-4771
    • Sudhakar, A.1    Sugimoto, H.2    Yang, C.3    Lively, J.4    Zeisberg, M.5
  • 56
    • 27644520996 scopus 로고    scopus 로고
    • The clinical potential of antiangiogenic fragments of extracellular matrix proteins
    • Clamp AR, Jayson GC, (2005) The clinical potential of antiangiogenic fragments of extracellular matrix proteins. Br J Cancer 93: 967-972.
    • (2005) Br J Cancer , vol.93 , pp. 967-972
    • Clamp, A.R.1    Jayson, G.C.2
  • 58
    • 0037081306 scopus 로고    scopus 로고
    • Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis
    • Deryugina EI, Soroceanu L, Strongin AY, (2002) Up-regulation of vascular endothelial growth factor by membrane-type 1 matrix metalloproteinase stimulates human glioma xenograft growth and angiogenesis. Cancer Res 62: 580-588.
    • (2002) Cancer Res , vol.62 , pp. 580-588
    • Deryugina, E.I.1    Soroceanu, L.2    Strongin, A.Y.3
  • 59
    • 0035813126 scopus 로고    scopus 로고
    • Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodeling
    • Galvez BG, Matias-Roman S, Albar JP, Sanchez-Madrid F, Arroyo AG, (2001) Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodeling. J Biol Chem 276: 37491-37500.
    • (2001) J Biol Chem , vol.276 , pp. 37491-37500
    • Galvez, B.G.1    Matias-Roman, S.2    Albar, J.P.3    Sanchez-Madrid, F.4    Arroyo, A.G.5
  • 60
    • 39649103854 scopus 로고    scopus 로고
    • Granulocyte-macrophage colony stimulating factor induces endothelial capillary formation through induction of membrane-type 1 matrix metalloproteinase expression in vitro
    • Krubasik D, Eisenach PA, Kunz-Schughart LA, Murphy G, English WR, (2008) Granulocyte-macrophage colony stimulating factor induces endothelial capillary formation through induction of membrane-type 1 matrix metalloproteinase expression in vitro. Int J Cancer 122: 1261-1272.
    • (2008) Int J Cancer , vol.122 , pp. 1261-1272
    • Krubasik, D.1    Eisenach, P.A.2    Kunz-Schughart, L.A.3    Murphy, G.4    English, W.R.5
  • 62
    • 0030697292 scopus 로고    scopus 로고
    • Three-dimensional cell cultures: from molecular mechanisms to clinical applications
    • Mueller-Klieser W, (1997) Three-dimensional cell cultures: from molecular mechanisms to clinical applications. Am J Physiol 273: C1109-1123.
    • (1997) Am J Physiol , vol.273
    • Mueller-Klieser, W.1
  • 63
    • 0033101647 scopus 로고    scopus 로고
    • Multicellular tumor spheroids: intermediates between monolayer culture and in vivo tumor
    • Kunz-Schughart LA, (1999) Multicellular tumor spheroids: intermediates between monolayer culture and in vivo tumor. Cell Biol Int 23: 157-161.
    • (1999) Cell Biol Int , vol.23 , pp. 157-161
    • Kunz-Schughart, L.A.1
  • 64
    • 34548410347 scopus 로고    scopus 로고
    • Use of multicellular tumor spheroids to dissect endothelial cell-tumor cell interactions: a role for T-cadherin in tumor angiogenesis
    • Ghosh S, Joshi MB, Ivanov D, Feder-Mengus C, Spagnoli GC, et al. (2007) Use of multicellular tumor spheroids to dissect endothelial cell-tumor cell interactions: a role for T-cadherin in tumor angiogenesis. FEBS Lett 581: 4523-4528.
    • (2007) FEBS Lett , vol.581 , pp. 4523-4528
    • Ghosh, S.1    Joshi, M.B.2    Ivanov, D.3    Feder-Mengus, C.4    Spagnoli, G.C.5
  • 65
    • 0026675287 scopus 로고
    • Interaction of human malignant melanoma (ST-ML-12) tumor spheroids with endothelial cell monolayers. Damage to endothelium by oxygen-derived free radicals
    • Offner FA, Wirtz HC, Schiefer J, Bigalke I, Klosterhalfen B, et al. (1992) Interaction of human malignant melanoma (ST-ML-12) tumor spheroids with endothelial cell monolayers. Damage to endothelium by oxygen-derived free radicals. Am J Pathol 141: 601-610.
    • (1992) Am J Pathol , vol.141 , pp. 601-610
    • Offner, F.A.1    Wirtz, H.C.2    Schiefer, J.3    Bigalke, I.4    Klosterhalfen, B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.