-
1
-
-
78049485263
-
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
-
Epub 2010 Jun 17
-
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010. Epub 2010 Jun 17.
-
(2010)
Int J Cancer
-
-
Ferlay, J.1
Shin, H.R.2
Bray, F.3
Forman, D.4
Mathers, C.5
Parkin, D.M.6
-
2
-
-
72449176846
-
Molecular origins of cancer: Molecular basis of colorectal cancer
-
Markowitz SD, Bertagnolli MM. Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med 2009;361:2449-60.
-
(2009)
N Engl J Med
, vol.361
, pp. 2449-2460
-
-
Markowitz, S.D.1
Bertagnolli, M.M.2
-
3
-
-
0025312728
-
A genetic model for colorectal tumorigenesis
-
Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990;61:759-67.
-
(1990)
Cell
, vol.61
, pp. 759-767
-
-
Fearon, E.R.1
Vogelstein, B.2
-
4
-
-
44049091352
-
Cancer stem cells - Old concepts, new insights
-
DOI 10.1038/cdd.2008.20, PII CDD200820
-
Vermeulen L, Sprick MR, Kemper K, Stassi G, Medema JP. Cancer stem cells-old concepts, new insights. Cell Death Differ 2008;15:947-58. (Pubitemid 351712600)
-
(2008)
Cell Death and Differentiation
, vol.15
, Issue.6
, pp. 947-958
-
-
Vermeulen, L.1
Sprick, M.R.2
Kemper, K.3
Stassi, G.4
Medema, J.P.5
-
5
-
-
33750313208
-
Cancer stem cells - Perspectives on current status and future directions: AACR workshop on cancer stem cells
-
DOI 10.1158/0008-5472.CAN-06-3126
-
Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, et al. Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 2006;66:9339-44. (Pubitemid 44623625)
-
(2006)
Cancer Research
, vol.66
, Issue.19
, pp. 9339-9344
-
-
Clarke, M.F.1
Dick, J.E.2
Dirks, P.B.3
Eaves, C.J.4
Jamieson, C.H.M.5
Jones, D.L.6
Visvader, J.7
Weissman, I.L.8
Wahl, G.M.9
-
6
-
-
33746808398
-
Wnt/beta-catenin signaling in development and disease
-
Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006;127:469-80.
-
(2006)
Cell
, vol.127
, pp. 469-480
-
-
Clevers, H.1
-
7
-
-
0033034120
-
beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation
-
DOI 10.1073/pnas.96.11.6273
-
Liu C, Kato Y, Zhang Z, Do VM, Yankner BA, He X. beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proc Natl Acad Sci U S A 1999;96:6273-8. (Pubitemid 29256655)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.11
, pp. 6273-6278
-
-
Liu, C.1
Kato, Y.2
Zhang, Z.3
Do, V.M.4
Yankner, B.A.5
He, X.6
-
8
-
-
34250827150
-
Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation
-
DOI 10.1126/science.1137065
-
Bilic J, Huang YL, Davidson G, Zimmermann T, Cruciat CM, Bienz M, et al. Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science 2007;316:1619-22. (Pubitemid 46982035)
-
(2007)
Science
, vol.316
, Issue.5831
, pp. 1619-1622
-
-
Bilic, J.1
Huang, Y.-L.2
Davidson, G.3
Zimmermann, T.4
Cruciat, C.-M.5
Bienz, M.6
Niehrs, C.7
-
9
-
-
18744400798
-
Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
-
DOI 10.1038/nsmb912
-
Daniels DL, Weis WI. Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat Struct Mol Biol 2005;12:364-71. (Pubitemid 43093092)
-
(2005)
Nature Structural and Molecular Biology
, vol.12
, Issue.4
, pp. 364-371
-
-
Daniels, D.L.1
Weis, W.I.2
-
10
-
-
0037023584
-
Wnt/Wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex
-
DOI 10.1016/S0092-8674(02)00679-7
-
Kramps T, Peter O, Brunner E, Nellen D, Froesch B, Chatterjee S, et al. Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell 2002;109:47-60. (Pubitemid 34327516)
-
(2002)
Cell
, vol.109
, Issue.1
, pp. 47-60
-
-
Kramps, T.1
Peter, O.2
Brunner, E.3
Nellen, D.4
Froesch, B.5
Chatterjee, S.6
Murone, M.7
Zullig, S.8
Basler, K.9
-
11
-
-
0032483439
-
Identification of c-MYC as a target of the APC pathway
-
DOI 10.1126/science.281.5382.1509
-
He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, et al. Identification of c-MYC as a target of the APC pathway. Science 1998;281:1509-12. (Pubitemid 28425575)
-
(1998)
Science
, vol.281
, Issue.5382
, pp. 1509-1512
-
-
He, T.-C.1
Sparks, A.B.2
Rago, C.3
Hermeking, H.4
Zawel, L.5
Da, C.L.T.6
Morin, P.J.7
Vogelstein, B.8
Kinzler, K.W.9
-
12
-
-
0036149985
-
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors
-
DOI 10.1128/MCB.22.4.1184-1193.2002
-
Lustig B, Jerchow B, Sachs M, Weiler S, Pietsch T, Karsten U, et al. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol 2002;22:1184-93. (Pubitemid 34094854)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.4
, pp. 1184-1193
-
-
Lustig, B.1
Jerchow, B.2
Sachs, M.3
Weiler, S.4
Pietsch, T.5
Karsten, U.6
De Van, W.M.7
Clevers, H.8
Schlag, P.M.9
Birchmeier, W.10
Behrens, J.11
-
13
-
-
33745052145
-
Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia
-
DOI 10.1038/sj.onc.1209382, PII 1209382
-
Jubb AM, Chalasani S, Frantz GD, Smits R, Grabsch HI, Kavi V, et al. Achaete-scute like 2 (ascl2) is a target of Wnt signaling and is upregulated in intestinal neoplasia. Oncogene 2006;25:3445-57. (Pubitemid 43877047)
-
(2006)
Oncogene
, vol.25
, Issue.24
, pp. 3445-3457
-
-
Jubb, A.M.1
Chalasani, S.2
Frantz, G.D.3
Smits, R.4
Grabsch, H.I.5
Kavi, V.6
Maughan, N.J.7
Hillan, K.J.8
Quirke, P.9
Koeppen, H.10
-
14
-
-
33846833986
-
The Morphogenetic Code and Colon Cancer Development
-
DOI 10.1016/j.ccr.2007.01.003, PII S1535610807000219
-
Van Den Brink GR, Offerhaus GJ. The morphogenetic code and colon cancer development. Cancer Cell 2007;11:109-17. (Pubitemid 46209852)
-
(2007)
Cancer Cell
, vol.11
, Issue.2
, pp. 109-117
-
-
Van, D.B.G.R.1
Offerhaus, G.J.2
-
15
-
-
23244448347
-
Expression pattern of Wnt signaling components in the adult intestine
-
DOI 10.1016/j.gastro.2005.06.007, PII S0016508505011054
-
Gregorieff A, Pinto D, Begthel H, Destree O, Kielman M, Clevers H. Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology 2005;129:626-38. (Pubitemid 41096648)
-
(2005)
Gastroenterology
, vol.129
, Issue.2
, pp. 626-638
-
-
Gregorieff, A.1
Pinto, D.2
Begthel, H.3
Destree, O.4
Kielman, M.5
Clevers, H.6
-
16
-
-
0346458662
-
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
-
DOI 10.1073/pnas.2536800100
-
Kuhnert F, Davis CR, Wang HT, Chu P, Lee M, Yuan J, et al. Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc Natl Acad Sci U S A 2004;101:266-71. (Pubitemid 38084239)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.1
, pp. 266-271
-
-
Kuhnert, F.1
Davis, C.R.2
Wang, H.-T.3
Chu, P.4
Lee, M.5
Yuan, J.6
Nusse, R.7
Kuo, C.J.8
-
17
-
-
18644373146
-
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells
-
DOI 10.1016/S0092-8674(02)01014-0
-
van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A, et al. The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 2002;111:241-50. (Pubitemid 35292444)
-
(2002)
Cell
, vol.111
, Issue.2
, pp. 241-250
-
-
De Van, W.M.1
Sancho, E.2
Verweij, C.3
De, L.W.4
Oving, I.5
Hurlstone, A.6
Van, D.H.K.7
Batlle, E.8
Coudreuse, D.9
Haramis, A.-P.10
Tjon-Pon-Fong, M.11
Moerer, P.12
Van, D.B.M.13
Soete, G.14
Pals, S.15
Eilers, M.16
Medema, R.17
Clevers, H.18
-
18
-
-
18644376279
-
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/EphrinB
-
DOI 10.1016/S0092-8674(02)01015-2
-
Batlle E, Henderson JT, Beghtel H, Van Den Born MM, Sancho E, Huls G, et al. Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell 2002;111:251-63. (Pubitemid 35292445)
-
(2002)
Cell
, vol.111
, Issue.2
, pp. 251-263
-
-
Batlle, E.1
Henderson, J.T.2
Beghtel, H.3
Van, D.B.M.M.W.4
Sancho, E.5
Huls, G.6
Meeldijk, J.7
Robertson, J.8
De Van, W.M.9
Pawson, T.10
Clevers, H.11
-
19
-
-
35548974423
-
Identification of stem cells in small intestine and colon by marker gene Lgr5
-
DOI 10.1038/nature06196, PII NATURE06196
-
Barker N, van Es JH, Kuipers J, Kujala P, Van Den Born M, Cozijnsen M, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007;449:1003-7. (Pubitemid 350014593)
-
(2007)
Nature
, vol.449
, Issue.7165
, pp. 1003-1007
-
-
Barker, N.1
Van, E.J.H.2
Kuipers, J.3
Kujala, P.4
Van, D.B.M.5
Cozijnsen, M.6
Haegebarth, A.7
Korving, J.8
Begthel, H.9
Peters, P.J.10
Clevers, H.11
-
20
-
-
61349150537
-
Transcription factor achaete scute-like 2 controls intestinal stem cell fate
-
Van Der Flier LG, van Gijn ME, Hatzis P, Kujala P, Haegebarth A, Stange DE, et al. Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell 2009;136:903-12.
-
(2009)
Cell
, vol.136
, pp. 903-912
-
-
Van Der Flier, L.G.1
Van Gijn, M.E.2
Hatzis, P.3
Kujala, P.4
Haegebarth, A.5
Stange, D.E.6
-
21
-
-
41649089525
-
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
-
DOI 10.1038/nature06835, PII NATURE06835
-
Malanchi I, Peinado H, Kassen D, Hussenet T, Metzger D, Chambon P, et al. Cutaneous cancer stem cell maintenance is dependent on beta-catenin signaling. Nature 2008;452:650-3. (Pubitemid 351483363)
-
(2008)
Nature
, vol.452
, Issue.7187
, pp. 650-653
-
-
Malanchi, I.1
Peinado, H.2
Kassen, D.3
Hussenet, T.4
Metzger, D.5
Chambon, P.6
Huber, M.7
Hohl, D.8
Cano, A.9
Birchmeier, W.10
Huelsken, J.11
-
22
-
-
0036154038
-
Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours
-
DOI 10.1002/path.1035
-
Wong SC, Lo SF, Lee KC, Yam JW, Chan JK, Wendy Hsiao WL. Expression of frizzled-related protein and Wnt-signaling molecules in invasive human breast tumours. J Pathol 2002;196:145-53. (Pubitemid 34110895)
-
(2002)
Journal of Pathology
, vol.196
, Issue.2
, pp. 145-153
-
-
Wong, S.C.C.1
Lo, S.F.E.2
Lee, K.C.3
Yam, J.W.P.4
Chan, J.K.C.5
Wendy, H.W.L.6
-
23
-
-
0025817880
-
Identification of FAP locus genes from chromosome 5q21
-
Kinzler KW, Nilbert MC, Su LK, Vogelstein B, Bryan TM, Levy DB, et al. Identification of FAP locus genes from chromosome 5q21. Science 1991;253:661-5. (Pubitemid 21917199)
-
(1991)
Science
, vol.253
, Issue.5020
, pp. 661-665
-
-
Kinzler, K.W.1
Nilbert, M.C.2
Su, L.-K.3
Vogelstein, B.4
Bryan, T.M.5
Levy, D.B.6
Smith, K.J.7
Preisinger, A.C.8
Hedge, P.9
Mckechnie, D.10
Finniear, R.11
Markham, A.12
Groffen, J.13
Boguski, M.S.14
Altschul, S.F.15
Horii, A.16
Ando, H.17
Miyoshi, Y.18
Miki, Y.19
Nishisho, I.20
Nakamura, Y.21
more..
-
24
-
-
0026894053
-
Somatic mutations of the APC gene in colorectal tumors: Mutation cluster region in the APC gene
-
Miyoshi Y, Nagase H, Ando H, Horii A, Ichii S, Nakatsuru S, et al. Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet 1992;1:229-33.
-
(1992)
Hum Mol Genet
, vol.1
, pp. 229-233
-
-
Miyoshi, Y.1
Nagase, H.2
Ando, H.3
Horii, A.4
Ichii, S.5
Nakatsuru, S.6
-
25
-
-
0026630266
-
APC mutations occur early during colorectal tumorigenesis
-
Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, et al. APC mutations occur early during colorectal tumorigenesis. Nature 1992;359:235-7.
-
(1992)
Nature
, vol.359
, pp. 235-237
-
-
Powell, S.M.1
Zilz, N.2
Beazer-Barclay, Y.3
Bryan, T.M.4
Hamilton, S.R.5
Thibodeau, S.N.6
-
26
-
-
44949226873
-
Tumour-stroma interactions in colorectal cancer: Converging on beta-catenin activation and cancer stemness
-
DOI 10.1038/sj.bjc.6604401, PII 6604401
-
Le NH, Franken P, Fodde R. Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness. Br J Cancer 2008;98:1886-93. (Pubitemid 351821566)
-
(2008)
British Journal of Cancer
, vol.98
, Issue.12
, pp. 1886-1893
-
-
Le, N.H.1
Franken, P.2
Fodde, R.3
-
27
-
-
77951975325
-
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
-
Vermeulen L, De Sousa E Melo, Van Der Heijden M, Cameron K, de Jong JH, Borovski T, et al. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol 2010;12:468-76.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 468-476
-
-
Vermeulen, L.1
De Melo, S.E.2
Van Der Heijden, M.3
Cameron, K.4
De Jong, J.H.5
Borovski, T.6
-
28
-
-
0032823133
-
The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: A new facet to Knudson's 'two-hit' hypothesis
-
Lamlum H, IlyasM, Rowan A, Clark S, Johnson V, Bell J, et al. The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis. Nat Med 1999;5:1071-5.
-
(1999)
Nat Med
, vol.5
, pp. 1071-1075
-
-
Lamlum, H.1
Ilyas, M.2
Rowan, A.3
Clark, S.4
Johnson, V.5
Bell, J.6
-
29
-
-
0037096906
-
The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade
-
Albuquerque C, Breukel C, Van Der LR, Fidalgo P, Lage P, Slors FJ, et al. The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade. Hum Mol Genet 2002;11:1549-60.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1549-1560
-
-
Albuquerque, C.1
Breukel, C.2
Van Der, L.R.3
Fidalgo, P.4
Lage, P.5
Slors, F.J.6
-
30
-
-
1642512639
-
Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex
-
DOI 10.1016/S1535-6108(03)00334-9
-
Lepourcelet M, Chen YN, France DS, Wang H, Crews P, Petersen F, et al. Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex. Cancer Cell 2004;5:91-102. (Pubitemid 38121599)
-
(2004)
Cancer Cell
, vol.5
, Issue.1
, pp. 91-102
-
-
Lepourcelet, M.1
Chen, Y.-N.P.2
France, D.S.3
Wang, H.4
Crews, P.5
Petersen, F.6
Bruseo, C.7
Wood, A.W.8
Shivdasani, R.A.9
-
31
-
-
58249122326
-
Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
-
Chen B, Dodge ME, Tang W, Lu J, Ma Z, Fan CW, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol 2009;5:100-7.
-
(2009)
Nat Chem Biol
, vol.5
, pp. 100-107
-
-
Chen, B.1
Dodge, M.E.2
Tang, W.3
Lu, J.4
Ma, Z.5
Fan, C.W.6
-
32
-
-
70349695861
-
Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling
-
Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling. Nature 2009;461:614-20.
-
(2009)
Nature
, vol.461
, pp. 614-620
-
-
Huang, S.M.1
Mishina, Y.M.2
Liu, S.3
Cheung, A.4
Stegmeier, F.5
Michaud, G.A.6
-
33
-
-
0030975671
-
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC(-/-) colon carcinoma
-
DOI 10.1126/science.275.5307.1784
-
Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, et al. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 1997;275:1784-7. (Pubitemid 27136714)
-
(1997)
Science
, vol.275
, Issue.5307
, pp. 1784-1787
-
-
Korinek, V.1
Barker, N.2
Morin, P.J.3
Van, W.D.4
De, W.R.5
Kinzler, K.W.6
Vogelstein, B.7
Clevers, H.8
-
34
-
-
1642341682
-
A Monoclonal Antibody against Wnt-1 Induces Apoptosis in Human Cancer Cells
-
He B, You L, Uematsu K, Xu Z, Lee AY, Matsangou M, et al. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia 2004;6:7-14. (Pubitemid 38391944)
-
(2004)
Neoplasia
, vol.6
, Issue.1
, pp. 7-14
-
-
He, B.1
You, L.2
Uematsu, K.3
Xu, Z.4
Lee, A.Y.5
Matsangou, M.6
McCormick, F.7
Jablons, D.M.8
-
35
-
-
18344377028
-
Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations
-
DOI 10.1038/sj.onc.1208511
-
He B, Reguart N, You L, Mazieres J, Xu Z, Lee AY, et al. Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations. Oncogene 2005;24:3054-8. (Pubitemid 40675537)
-
(2005)
Oncogene
, vol.24
, Issue.18
, pp. 3054-3058
-
-
He, B.1
Reguart, N.2
You, L.3
Mazieres, J.4
Xu, Z.5
Lee, A.Y.6
Mikami, I.7
McCormick, F.8
Jablons, D.M.9
-
36
-
-
12144291274
-
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
-
DOI 10.1038/ng1330
-
Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen WD, et al. Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 2004;36:417-22. (Pubitemid 38437267)
-
(2004)
Nature Genetics
, vol.36
, Issue.4
, pp. 417-422
-
-
Suzuki, H.1
Watkins, D.N.2
Jair, K.-W.3
Schuebel, K.E.4
Markowitz, S.D.5
Chen, W.D.6
Pretlow, T.P.7
Yang, B.8
Akiyama, Y.9
Van, E.M.10
Toyota, M.11
Tokino, T.12
Hinoda, Y.13
Imai, K.14
Herman, J.G.15
Baylin, S.B.16
-
37
-
-
0032998688
-
Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium
-
Chang JT, Esumi N, Moore K, Li Y, Zhang S, Chew C, et al. Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium. Hum Mol Genet 1999;8:575-83. (Pubitemid 29139970)
-
(1999)
Human Molecular Genetics
, vol.8
, Issue.4
, pp. 575-583
-
-
Chang, J.T.1
Esumi, N.2
Moore, K.3
Li, Y.4
Zhang, S.5
Chew, C.6
Goodman, B.7
Rattner, A.8
Moody, S.9
Stetten, G.10
Campochiaro, P.A.11
Zack, D.J.12
-
38
-
-
21644446778
-
Arming antibodies for cancer therapy
-
DOI 10.1016/j.coph.2005.04.008, PII S1471489205000779
-
Polakis P. Arming antibodies for cancer therapy. Curr Opin Pharmacol 2005;5:382-7. (Pubitemid 40932040)
-
(2005)
Current Opinion in Pharmacology
, vol.5
, Issue.4 SPEC. ISS
, pp. 382-387
-
-
Polakis, P.1
-
39
-
-
4344587136
-
A small molecule inhibitor of beta-catenin/cyclic AMP response element-binding protein transcription
-
DOI 10.1073/pnas.0404875101
-
Emami KH, Nguyen C, Ma H, Kim DH, Jeong KW, Eguchi M, et al. A small molecule inhibitor of beta-catenin/CREB-binding protein transcription. Proc Natl Acad Sci U S A 2004;101:12682-7. (Pubitemid 39122083)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.34
, pp. 12682-12687
-
-
Emami, K.H.1
Nguyen, C.2
Ma, H.3
Kim, D.H.4
Jeong, K.W.5
Eguchi, M.6
Moon, R.T.7
Teo, J.-L.8
Oh, S.W.9
Kim, H.Y.10
Moon, S.H.11
Hall, J.R.12
Kahn, M.13
-
40
-
-
0037737728
-
A role for Wnt signalling in self-renewal of haematopoietic stem cells
-
DOI 10.1038/nature01593
-
Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, Willert K, et al. A role for Wnt signaling in self-renewal of haematopoietic stem cells. Nature 2003;423:409-14. (Pubitemid 36626987)
-
(2003)
Nature
, vol.423
, Issue.6938
, pp. 409-414
-
-
Reya, T.1
Duncan, A.W.2
Ailles, L.3
Domen, J.4
Scherer, D.C.5
Willert, K.6
Hintz, L.7
Nusse, R.8
Weissman, I.L.9
-
41
-
-
0031430056
-
Aspirin and gastrointestinal cancer
-
Thun MJ. Aspirin and gastrointestinal cancer. Adv Exp Med Biol 1997;400A:395-402.
-
(1997)
Adv Exp Med Biol
, vol.400 A
, pp. 395-402
-
-
Thun, M.J.1
-
42
-
-
9344257283
-
Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis
-
Boolbol SK, Dannenberg AJ, Chadburn A, Martucci C, Guo XJ, Ramonetti JT, et al. Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. Cancer Res 1996;56:2556-60. (Pubitemid 26171681)
-
(1996)
Cancer Research
, vol.56
, Issue.11
, pp. 2556-2560
-
-
Boolbol, S.K.1
Dannenberg, A.J.2
Chadburn, A.3
Martucci, C.4
Guo, X.5
Ramonetti, J.T.6
Abreu-Goris, M.7
Newmark, H.L.8
Lipkin, M.L.9
DeCosse, J.J.10
Bertagnolli, M.M.11
-
43
-
-
0030461132
-
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
-
Kurumbail RG, Stevens AM, Gierse JK, McDonald JJ, Stegeman RA, Pak JY, et al. Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature 1996;384:644-8.
-
(1996)
Nature
, vol.384
, pp. 644-648
-
-
Kurumbail, R.G.1
Stevens, A.M.2
Gierse, J.K.3
McDonald, J.J.4
Stegeman, R.A.5
Pak, J.Y.6
-
44
-
-
0028261042
-
2
-
Pugh S, Thomas GA. Patients with adenomatous polyps and carcinomas have increased colonic mucosal prostaglandin E2. Gut 1994;35:675-8. (Pubitemid 24163797)
-
(1994)
Gut
, vol.35
, Issue.5
, pp. 675-678
-
-
Pugh, S.1
Thomas, G.A.O.2
-
45
-
-
0037454960
-
Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth
-
Amano H, Hayashi I, Endo H, Kitasato H, Yamashina S, Maruyama T, et al. Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. J Exp Med 2003;197:221-32.
-
(2003)
J Exp Med
, vol.197
, pp. 221-232
-
-
Amano, H.1
Hayashi, I.2
Endo, H.3
Kitasato, H.4
Yamashina, S.5
Maruyama, T.6
-
46
-
-
28544444039
-
s-axin-beta-catenin signaling axis
-
DOI 10.1126/science.1116221
-
Castellone MD, Teramoto H, Williams BO, Druey KM, Gutkind JS. Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science 2005;310:1504-10. (Pubitemid 41746348)
-
(2005)
Science
, vol.310
, Issue.5753
, pp. 1504-1510
-
-
Castellone, M.D.1
Teramoto, H.2
Williams, B.O.3
Druey, K.M.4
Gutkind, J.S.5
-
47
-
-
23444442691
-
Targeting the beta-catenin/APC pathway: A novel mechanism to explain the cyclooxygenase-2-independent anticarcinogenic effects of celecoxib in human colon carcinoma cells
-
DOI 10.1096/fj.04-3274fje
-
Maier TJ, Janssen A, Schmidt R, Geisslinger G, Grosch S. Targeting the beta-catenin/APC pathway: a novel mechanism to explain the cyclooxygenase-2- independent anticarcinogenic effects of celecoxib in human colon carcinoma cells. FASEB J 2005;19:1353-5. (Pubitemid 41113747)
-
(2005)
FASEB Journal
, vol.19
, Issue.10
, pp. 1353-1355
-
-
Maier, T.J.1
Janssen, A.2
Schmidt, R.3
Geisslinger, G.4
Grosch, S.5
-
48
-
-
33745238704
-
Cyclooxygenase-2 (COX-2) - Independent anticarcinogenic effects of selective COX-2 inhibitors
-
DOI 10.1093/jnci/djj206
-
Grosch S, Maier TJ, Schiffmann S, Geisslinger G. Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors. J Natl Cancer Inst 2006;98:736-47. (Pubitemid 43983297)
-
(2006)
Journal of the National Cancer Institute
, vol.98
, Issue.11
, pp. 736-747
-
-
Grosch, S.1
Maier, T.J.2
Schiffmann, S.3
Geisslinger, G.4
-
49
-
-
0034057928
-
The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cellsevidence of different mechanisms of action
-
DOI 10.1016/S0959-8049(99)00333-0, PII S0959804999003330
-
Smith ML, Hawcroft G, Hull MA. The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action. Eur J Cancer 2000;36:664-74. (Pubitemid 30156854)
-
(2000)
European Journal of Cancer
, vol.36
, Issue.5
, pp. 664-674
-
-
Smith, M.-L.1
Hawcroft, G.2
Hull, M.A.3
-
50
-
-
0035650943
-
COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib
-
Grosch S, Tegeder I, Niederberger E, Brautigam L, Geisslinger G. COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib. FASEB J 2001;15:2742-4.
-
(2001)
FASEB J
, vol.15
, pp. 2742-2744
-
-
Grosch, S.1
Tegeder, I.2
Niederberger, E.3
Brautigam, L.4
Geisslinger, G.5
-
51
-
-
39449084394
-
Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer
-
DOI 10.1158/0008-5472.CAN-07-5172
-
Tuynman JB, Vermeulen L, Boon EM, Kemper K, Zwinderman AH, Peppelenbosch MP, et al. Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer. Cancer Res 2008;68:1213-20. (Pubitemid 351272241)
-
(2008)
Cancer Research
, vol.68
, Issue.4
, pp. 1213-1220
-
-
Tuynman, J.B.1
Vermeulen, L.2
Boon, E.M.3
Kemper, K.4
Zwinderman, A.H.5
Peppelenbosch, M.P.6
Richel, D.J.7
-
52
-
-
0036531819
-
Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes
-
Monga SP, Mars WM, Pediaditakis P, Bell A, Mulé K, Bowen WC, et al. Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes. Cancer Res 2002;62:2064-71. (Pubitemid 34408453)
-
(2002)
Cancer Research
, vol.62
, Issue.7
, pp. 2064-2071
-
-
Monga, S.P.S.1
Mars, W.M.2
Pediaditakis, P.3
Bell, A.4
Mule, K.5
Bowen, W.C.6
Wang, X.7
Zarnegar, R.8
Michalopoulos, G.K.9
-
53
-
-
33847014441
-
A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth
-
Rasola A, Fassetta M, De Bacco F, D'Alessandro L, Gramaglia D, Di Renzo MF, et al. A positive feedback loop between hepatocyte growth factor receptor and beta-catenin sustains colorectal cancer cell invasive growth. Oncogene 2007;26:1078-87.
-
(2007)
Oncogene
, vol.26
, pp. 1078-1087
-
-
Rasola, A.1
Fassetta, M.2
De Bacco, F.3
D'Alessandro, L.4
Gramaglia, D.5
Di Renzo, M.F.6
-
54
-
-
34249661591
-
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity
-
DOI 10.1074/jbc.M611871200
-
Fang D, Hawke D, Zheng Y, Xia Y, Meisenhelder J, Nika H, et al. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem 2007;282:11221-9. (Pubitemid 47100795)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.15
, pp. 11221-11229
-
-
Fang, D.1
Hawke, D.2
Zheng, Y.3
Xia, Y.4
Meisenhelder, J.5
Nika, H.6
Mills, G.B.7
Kobayashi, R.8
Hunter, T.9
Lu, Z.10
-
55
-
-
17744418769
-
The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis
-
DOI 10.1056/NEJM200006293422603
-
Steinbach G, Lynch PM, Phillips RK, Wallace MH, Hawk E, Gordon GB, et al. The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med 2000;342:1946-52. (Pubitemid 30419089)
-
(2000)
New England Journal of Medicine
, vol.342
, Issue.26
, pp. 1946-1952
-
-
Steinbach, G.1
Lynch, P.M.2
Phillips, R.K.S.3
Wallace, M.H.4
Hawk, E.5
Gordon, G.B.6
Wakabayashi, N.7
Saunders, B.8
Shen, Y.9
Fujimura, T.10
Su, L.-K.11
Levin, B.12
Godio, L.13
Patterson, S.14
Rodriguez-Bigas, M.A.15
Jester, S.L.16
King, K.L.17
Schumacher, M.18
Abbruzzese, J.19
DuBois, R.N.20
Hittelman, W.N.21
Zimmerman, S.22
Sherman, J.W.23
Kelloff, G.24
more..
-
56
-
-
20144365496
-
Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention
-
DOI 10.1056/NEJMoa050405
-
Solomon SD, McMurray JJ, Pfeffer MA, Wittes J, Fowler R, Finn P, et al. Cardiovascular risk associated with celecoxib in a clinical trial for colorectal adenoma prevention. N Engl J Med 2005;352:1071-80. (Pubitemid 40365348)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.11
, pp. 1071-1080
-
-
Solomon, S.D.1
McMurray, J.J.V.2
Pfeffer, M.A.3
Wittes, J.4
Fowler, R.5
Finn, P.6
Anderson, W.F.7
Zauber, A.8
Hawk, E.9
Bertagnolli, M.10
-
57
-
-
77955928161
-
Tumors as organs: Complex tissues that interface with the entire organism
-
Egeblad M, Nakasone ES, Werb Z. Tumors as organs: complex tissues that interface with the entire organism. Dev Cell 2010;18:884-901.
-
(2010)
Dev Cell
, vol.18
, pp. 884-901
-
-
Egeblad, M.1
Nakasone, E.S.2
Werb, Z.3
-
58
-
-
51649111430
-
Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity
-
Vermeulen L, Todaro M, de Sousa MF, Sprick MR, Kemper K, Perez Alea M, et al. Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. Proc Natl Acad Sci U S A 2008;105:13427-32.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 13427-13432
-
-
Vermeulen, L.1
Todaro, M.2
De Sousa, M.F.3
Sprick, M.R.4
Kemper, K.5
Perez Alea, M.6
-
59
-
-
33846029123
-
A Perivascular Niche for Brain Tumor Stem Cells
-
DOI 10.1016/j.ccr.2006.11.020, PII S1535610806003692
-
Calabrese C, Poppleton H, Kocak M, Hogg TL, Fuller C, Hamner B, et al. A perivascular niche for brain tumor stem cells. Cancer Cell 2007;11:69-82. (Pubitemid 46054518)
-
(2007)
Cancer Cell
, vol.11
, Issue.1
, pp. 69-82
-
-
Calabrese, C.1
Poppleton, H.2
Kocak, M.3
Hogg, T.L.4
Fuller, C.5
Hamner, B.6
Oh, E.Y.7
Gaber, M.W.8
Finklestein, D.9
Allen, M.10
Frank, A.11
Bayazitov, I.T.12
Zakharenko, S.S.13
Gajjar, A.14
Davidoff, A.15
Gilbertson, R.J.16
-
60
-
-
65549135781
-
Discovery of fully human anti-MET monoclonal antibodies with antitumor activity against colon cancer tumor models in vivo
-
Van Der Horst EH, Chinn L, Wang M, Velilla T, Tran H, Madrona Y, et al. Discovery of fully human anti-MET monoclonal antibodies with antitumor activity against colon cancer tumor models in vivo. Neoplasia 2009;11:355-64.
-
(2009)
Neoplasia
, vol.11
, pp. 355-364
-
-
Van Der Horst, E.H.1
Chinn, L.2
Wang, M.3
Velilla, T.4
Tran, H.5
Madrona, Y.6
-
61
-
-
34249324494
-
An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms
-
DOI 10.1158/0008-5472.CAN-06-4443
-
Zou HY, Li Q, Lee JH, Arango ME, McDonnell SR, Yamazaki S, et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res 2007;67:4408-17. (Pubitemid 46815090)
-
(2007)
Cancer Research
, vol.67
, Issue.9
, pp. 4408-4417
-
-
Zou, H.Y.1
Li, Q.2
Lee, J.H.3
Arango, M.E.4
McDonnell, S.R.5
Yamazaki, S.6
Koudriakova, T.B.7
Alton, G.8
Cui, J.J.9
Kung, P.-P.10
Nambu, M.D.11
Los, G.12
Bender, S.L.13
Mroczkowski, B.14
Christensen, J.G.15
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