The complex role of multivalency in nanoparticles targeting the transferrin receptor for cancer therapies

Journal of the American Chemical Society

Volumn 132, Issue 32, 2010, Pages 11306-11313

  Wang, Jin ^a,c,d   Tian, Shaomin ^a,c,d   Petros, Robby A ^a,c,g   Napier, Mary E ^a,c,d   Desimone, Joseph M ^a,b,c,d,e,f  

^a University of North Carolina at Chapel Hill   (United States)

^b University of North Carolina   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e North Carolina State University   (United States)

^f MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^g UNIVERSITY OF NORTH TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; B-CELL LYMPHOMA; CANCER THERAPY; CASPASES; CELL SURFACE RECEPTORS; CELL VIABILITY; COMPLEX ROLES; DIFFERENT MECHANISMS; ENDOSOMES; HUMAN TUMOR CELLS; INTRACELLULAR COMPARTMENTS; LIGAND DENSITY; MALIGNANT TISSUES; MULTIVALENCY; NEGATIVE CONTROL; OVER-EXPRESSION; PARTICLE CONCENTRATIONS; PARTICLE SURFACE; PARTICLE UPTAKES; SOLID TUMORS; STRONG CORRELATION; TARGETED CHEMOTHERAPY; TARGETED DRUG DELIVERY; TARGETING MOLECULES; THERAPEUTIC TARGETS; TRANSFERRIN RECEPTORS;

CELL CULTURE; CELL DEATH; CELL MEMBRANES; CHEMOTHERAPY; CYTOTOXICITY; DRUG DELIVERY; ETHYLENE; ETHYLENE GLYCOL; LIGANDS; ONCOLOGY; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; TOXIC MATERIALS; TUMORS;

NANOPARTICLES;

ANTIBODY CONJUGATE; CASPASE 3; CASPASE 7; MACROGOL; MONOCLONAL ANTIBODY; NANOPARTICLE; NANOPARTICLE CONJUGATED TRANSFERRIN; NANOPARTICLE CONNJUGATED MONOCLONAL ANTIBODY OKT9; TRANSFERRIN; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL STRAIN HEK293; CELL VIABILITY; CONTROLLED STUDY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG TARGETING; DRUG UPTAKE; ENZYME ACTIVITY; HELA CELL; HUMAN; HUMAN CELL; INTERNALIZATION; NANOTECHNOLOGY; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; BIOLOGICAL TRANSPORT; CATTLE; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; HYDROGEN-ION CONCENTRATION; LIGANDS; LYMPHOMA, NON-HODGKIN; NANOPARTICLES; NANOTECHNOLOGY; POLYETHYLENE GLYCOLS; RECEPTORS, TRANSFERRIN;

EID: 77955562994     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja1043177     Document Type: Article

References (42)

1. Daniels, T. R., Delgado, T., Rodriguez, J. A., Helguera, G., and Penichet, M. L. Clin. Immunol. 2006, 121, 144
2. Macedo, M. F. and de Sousa, M. Inflamm. Allergy Drug Targets 2008, 7, 41
3. Li, H. and Qian, Z. M. Med. Res. Rev. 2002, 22, 225
4. Daniels, T. R., Delgado, T., Helguera, G., and Penichet, M. L. Clin. Immunol. 2006, 121, 159
5. Choi, C. H. J., Alabi, C. A., Webster, P., and Davis, M. E. Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 1235
6. Heath, J. R. and Davis, M. E. Annu. Rev. Med. 2008, 59, 251
7. Heidel, J. D., Yu, Z., Liu, J. Y., Rele, S. M., Liang, Y., Zeidan, R. K., Kornbrust, D. J., and Davis, M. E. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 5715
8. Bellocq, N. C., Pun, S. H., Jensen, G. S., and Davis, M. E. Bioconjugate Chem. 2003, 14, 1122
9. Davis, M. E., Zuckerman, J. E., Choi, C. H., Seligson, D., Tolcher, A., Alabi, C. A., Yen, Y., Heidel, J. D., and Ribas, A. Nature 2010, 464, 1067
10. Davis, M. E. Mol. Pharm. 2009, 6, 659
11. Kang, B., Mackey, M. A., and El-Sayed, M. A. J. Am. Chem. Soc. 2010, 132, 1517
12. Byrne, J. D., Betancourt, T., and Brannon-Peppas, L. Adv. Drug Delivery Rev. 2008, 60, 1615
13. Escorcia, F. E., McDevitt, M. R., Villa, C. H., and Scheinberg, D. A. Nanomedicine 2007, 2, 805
14. Kabanov, A. V. and Vinogradov, S. V. Angew. Chem., Int. Ed. 2009, 48, 5418
15. Ogris, M., Walker, G., Blessing, T., Kircheis, R., Wolschek, M., and Wagner, E. J. Controlled Release 2003, 91, 173
16. Rosi, N. and Mirkin, C. Chem. Rev. 2005, 105, 1547
17. Cheng, Z., Wu, Y., Xiong, Z., Gambhir, S. S., and Chen, X. Bioconjugate Chem 2005, 16, 1433
18. Huang, Y. F., Liu, H., Xiong, X., Chen, Y., and Tan, W. J. Am. Chem. Soc. 2009, 131, 17328
19. Bowman, M. C., Ballard, T. E., Ackerson, C. J., Feldheim, D. L., Margolis, D. M., and Melander, C. J. Am. Chem. Soc. 2008, 130, 6896
20. Muro, S., Garnacho, C., Champion, J. A., Leferovich, J., Gajewski, C., Schuchman, E. H., Mitragotri, S., and Muzykantov, V. R. Mol. Ther. 2008, 16, 1450
21. Jiang, W., Kim, B. Y., Rutka, J. T., and Chan, W. C. Nat. Nanotechnol. 2008, 3, 145
22. Chiu, G. N., Edwards, L. A., Kapanen, A. I., Malinen, M. M., Dragowska, W. H., Warburton, C., Chikh, G. G., Fang, K. Y., Tan, S., Sy, J., Tucker, C., Waterhouse, D. N., Klasa, R., and Bally, M. B. Mol. Cancer Ther. 2007, 6, 844
23. Rolland, J., Maynor, B., Euliss, L., Exner, A., Denison, G., and DeSimone, J. J. Am. Chem. Soc. 2005, 127, 10096
24. Euliss, L., DuPont, J., Gratton, S., and DeSimone, J. Chem. Soc. Rev. 2006, 35, 1095
25. Kelly, J. and DeSimone, J. J. Am. Chem. Soc. 2008, 130, 5438
26. Zhang, H., Nunes, J., Gratton, S., Herlihy, K., Pohlhaus, P., and DeSimone, J. New J. Phys. 2009, 11 075018
27. Bártek, J., Viklický, V., and Stratil, A. Br. J. Hamaetol. 1985, 59, 435
28. Gratton, S. E. A., Ropp, P. A., Pohlhaus, P. D., Luft, J. C., Madden, V. J., Napier, M. E., and DeSimone, J. M. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 11613
29. Bartlett, D. and Davis, M. Bioconjugate Chem. 2007, 18, 456
30. Trowbridge, I. and Domingo, D. Nature 1981, 294, 171
31. Trowbridge, I. S. and Lopez, F. Proc. Natl. Acad. Sci. U.S.A. 1982, 79, 1175
32. Lesley, J. F. and Schulte, R. J. Mol. Cell Biol. 1985, 5, 1814
33. White, S., Taetle, R., Seligman, P. A., Rutherford, M., and Trowbridge, I. S. Cancer Res. 1990, 50, 6295
34. Taetle, R., Castagnola, J., and Mendelsohn, J. Cancer Res. 1986, 46, 1759
35. Ng, P. P., Dela Cruz, J. S., Sorour, D. N., Stinebaugh, J. M., Shin, S. U., Shin, D. S., Morrison, S. L., and Penichet, M. L. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 10706
36. Leonard, D., Hayakawa, A., Lawe, D., Lambright, D., Bellve, K., Standley, C., Lifshitz, L., Fogarty, K., and Corvera, S. J. Cell Sci. 2008, 121, 3445
37. Marsh, E. W., Leopold, P. L., Jones, N. L., and Maxfield, F. R. J. Cell Biol. 1995, 129, 1509
38. Fodor, I., Egyed, A., and Lelkes, G. Eur. J. Cell Biol. 1986, 42, 74
39. Weissman, A. M., Klausner, R. D., Rao, K., and Harford, J. B. J. Cell Biol. 1986, 102, 951
40. Ng, P. P., Helguera, G., Daniels, T. R., Lomas, S. Z., Rodriguez, J. A., Schiller, G., Bonavida, B., Morrison, S. L., and Penichet, M. L. Blood 2006, 108, 2745
41. Jiao, Y., Wilkinson, J. t., Christine Pietsch, E., Buss, J. L., Wang, W., Planalp, R., Torti, F. M., and Torti, S. V. Free Radic. Biol. Med. 2006, 40, 1152
42. Mosley, C. A., Liotta, D. C., and Snyder, J. P. Adv. Exp. Med. Biol. 2007, 595, 77