Co-delivery of hydrophobic and hydrophilic drugsfrom nanoparticle-aptamer bioconjugates

ChemMedChem

Volumn 2, Issue 9, 2007, Pages 1268-1271

  Zhang, Liangfang ^b   Radovic Moreno, Aleksandar F ^b   Alexis, Frank ^a   Gu, Frank X ^b   Basto, Pamela A ^b   Bagalkot, Vaishali ^c   Jon, Sangyong ^c   Langer, Robert S ^b   Farokhzad, Omid C ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c Gwangju Institute of Science and Technology (GIST)   (South Korea)

Author keywords

Antitumor agents; Conjugation; Dual drug delivery; Nanoparticles; Targeted therapy

Indexed keywords

ANTINEOPLASTIC AGENT; APTAMER; DRUG; NANOPARTICLE;

ADENOCARCINOMA; ARTICLE; CHEMISTRY; FLUORESCENCE MICROSCOPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; PATHOLOGY; PROSTATE TUMOR; TUMOR CELL LINE;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; APTAMERS, NUCLEOTIDE; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MALE; MICROSCOPY, FLUORESCENCE; NANOPARTICLES; PHARMACEUTICAL PREPARATIONS; PROSTATIC NEOPLASMS;

EID: 42349106952     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200700121     Document Type: Article

References (18)

1. J. Kost, R. Langer, Adv. Drug Delivery Rev. 2001, 46, 125-148.
2. S. M. Moghimi, J. Szebeni, Prog. Lipid Res. 2003, 42, 463-478.
3. N. A. Peppas, J. Z. Hilt, A. Khademhosseini, R. Langer, Adv. Mater. 2006, 18, 1345-1360.
4. O. C. Farokhzad, R. Langer, Adv. Drug Delivery Rev. 2006, 58, 1456-1459.
5. R. Langer, Nature 1998, 392, 5-10.
6. T. Minko, S. S. Dharap, R. I. Pakunlu, Y. Wang, Curr. Drug Targets 2004, 5, 389-406.
7. S. Mitragotri, Pharm. Res. 2000, 17, 1354-1359.
8. C. Walsh, Nature 2000, 406, 775-781.
9. F. Liu, L. M. Shollenberger, L. Huang, FASEB J. 2004, 18, 1779-1781.
10. Y. Wang, S. Gao, W.-H. Ye, H. S. Yoon, Y.-Y. Yang, Nat. Mater. 2006, 5, 791-796.
11. S. Sengupta, D. Eavarone, I. Capila, G. Zhao, N. Watson, T. Kiziltepe, R. Sasisekharan, Nature 2005, 436, 568-572.
12. O. C. Farokhzad, J. S. Jon, A. Khademhosseini, T-N. T. Tran, D. A. LaVan, R. Langer, Cancer Res. 2004, 64, 7668-7672.
13. O. C. Farokhzad, J. Cheng, B. A. Teply, I. Sherifi, S. Jon, P.W. Kantoff, J. P. Richie, R. Langer, Proc. Natl. Acad. Sci. USA 2006, 103, 6315-6320.
14. V. Bagalkot, O. C. Farokhzad, R. Langer, S. Jon, Angew. Chem. 2006, 118, 8329-8332;
15. Angew. Chem. Int. Ed. 2006, 45, 8149-8152.
16. S. E. Lupold, B. J. Hicke, Y. Lin, D. S. Coffey, Cancer Res. 2002, 62, 4029-4033.
17. J. B. Chaires, J. E. Herrera, M. J. Waring, Biochemistry 1990, 29, 6145-6153.
18. J. Cheng, B. A. Teply, I. Sherifi, J. Sung, G. Luther, F. X. Gu, E. Levy-Nissenbaum, A. F. Radovic-Moreno, R. Langer, O. C. Farokhzad, Biomaterials 2007, 28, 869-876.