메뉴 건너뛰기




Volumn 6, Issue , 2012, Pages 179-187

Trastuzumab for HER2-positive metastatic breast cancer: Clinical and economic considerations

Author keywords

Breast cancer; Clinical trials; Cost effectiveness analysis; Economics; HER2 positive; Palliative; Trastuzumab

Indexed keywords

ANASTROZOLE; CAPECITABINE; CARBOPLATIN; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; LAPATINIB; LETROZOLE; NAVELBINE; PACLITAXEL; PERTUZUMAB; TRASTUZUMAB; TRASTUZUMAB EMTANSINE;

EID: 84859727619     PISSN: 11795549     EISSN: 11795549     Source Type: Journal    
DOI: 10.4137/CMO.S6460     Document Type: Review
Times cited : (29)

References (48)
  • 1
    • 79251644460 scopus 로고    scopus 로고
    • HER2: Biology, detection, and clinical implications
    • Gutierrez C, Schiff R. HER2: biology, detection, and clinical implications. Arch Pathol Lab Med. 2011;135(1):55-62.
    • (2011) Arch Pathol Lab Med , vol.135 , Issue.1 , pp. 55-62
    • Gutierrez, C.1    Schiff, R.2
  • 2
    • 73949090721 scopus 로고    scopus 로고
    • Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: An institutionalbased review
    • Dawood S, Broglio K, Buzdar AU, et al. Prognosis of women with metastatic breast cancer by HER2 status and trastuzumab treatment: an institutionalbased review. J Clin Oncol. 2010;28(1):92-98.
    • (2010) J Clin Oncol , vol.28 , Issue.1 , pp. 92-98
    • Dawood, S.1    Broglio, K.2    Buzdar, A.U.3
  • 3
    • 34447306848 scopus 로고    scopus 로고
    • Trastuzumab: Mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer
    • Jun
    • Valabrega G, Montemurro F, Aglietta M. Trastuzumab: mechanism of action, resistance and future perspectives in HER2-overexpressing breast cancer. Ann Oncol. Jun 2007;18(6):977-984.
    • (2007) Ann Oncol , vol.18 , Issue.6 , pp. 977-984
    • Valabrega, G.1    Montemurro, F.2    Aglietta, M.3
  • 4
    • 25144517586 scopus 로고    scopus 로고
    • Evaluation of clinical outcomes according to HER2 detection by fluorescence in situ hybridization in women with metastatic breast cancer treated with trastuzumab
    • Mass RD, Press MF, Anderson S, et al. Evaluation of clinical outcomes according to HER2 detection by fluorescence in situ hybridization in women with metastatic breast cancer treated with trastuzumab. Clin Breast Cancer. 2005;6(3):240-246.
    • (2005) Clin Breast Cancer , vol.6 , Issue.3 , pp. 240-246
    • Mass, R.D.1    Press, M.F.2    Anderson, S.3
  • 5
    • 68949112230 scopus 로고    scopus 로고
    • American Society of Clinical Oncology Guidance Statement: The cost of cancer care
    • Meropol NJ, Schrag D, Smith TJ, et al. American Society of Clinical Oncology Guidance Statement: the cost of cancer care. J Clin Oncol. 2009;27(23):3868-3874.
    • (2009) J Clin Oncol , vol.27 , Issue.23 , pp. 3868-3874
    • Meropol, N.J.1    Schrag, D.2    Smith, T.J.3
  • 6
    • 0022406444 scopus 로고
    • Amplification of a novel v-erbBrelated gene in a human mammary carcinoma
    • Sep 6
    • King CR, Kraus MH, Aaronson SA. Amplification of a novel v-erbBrelated gene in a human mammary carcinoma. Science. Sep 6, 1985; 229(4717):974-976.
    • (1985) Science , vol.229 , Issue.4717 , pp. 974-976
    • King, C.R.1    Kraus, M.H.2    Aaronson, S.A.3
  • 7
    • 0033608993 scopus 로고    scopus 로고
    • The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors
    • Klapper LN, Glathe S, Vaisman N, et al. The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors. Proc Natl Acad Sci U S A. 1999;96: 4995-5000.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 4995-5000
    • Klapper, L.N.1    Glathe, S.2    Vaisman, N.3
  • 8
    • 0030030072 scopus 로고    scopus 로고
    • ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: Implications for breast cancer
    • Karunagaran D, Tzahar E, Beerli RR, et al. ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. EMBO J. 1996;15:254-264.
    • (1996) EMBO J , vol.15 , pp. 254-264
    • Karunagaran, D.1    Tzahar, E.2    Beerli, R.R.3
  • 9
    • 0001223491 scopus 로고    scopus 로고
    • Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
    • Petit AM, Rak J, Hung MC, et al. Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. Am J Pathol. 1997;151:1523-1530.
    • (1997) Am J Pathol , vol.151 , pp. 1523-1530
    • Petit, A.M.1    Rak, J.2    Hung, M.C.3
  • 10
    • 9744250235 scopus 로고    scopus 로고
    • c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent
    • Giatromanolaki A, Koukourakis MI, Simopoulos C, et al. c-erbB-2 related aggressiveness in breast cancer is hypoxia inducible factor-1alpha dependent. Clin Cancer Res. 2004;10:7972-7977.
    • (2004) Clin Cancer Res , vol.10 , pp. 7972-7977
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Simopoulos, C.3
  • 11
    • 0024651788 scopus 로고
    • Localization of the human erbB-2 gene on normal and rearranged chromosomes 17 to bands q12-21.32
    • Popescu NC, King CR, Kraus MH. Localization of the human erbB-2 gene on normal and rearranged chromosomes 17 to bands q12-21.32. Genomics. 1989;4:362-366.
    • (1989) Genomics , vol.4 , pp. 362-366
    • Popescu, N.C.1    King, C.R.2    Kraus, M.H.3
  • 12
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets
    • Apr
    • Clynes RA, Towers TL, Presta LG, Ravetch JV. Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets. Nat Med. Apr 2000; 6(4):443-446.
    • (2000) Nat Med , vol.6 , Issue.4 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 13
    • 35649005398 scopus 로고    scopus 로고
    • Long term disease-free survival and T cell and antibody responses in women with high-risk Her2+ breast cancer following vaccination against Her2
    • Sep 6
    • Morse MA, Hobeika A, Osada T, et al. Long term disease-free survival and T cell and antibody responses in women with high-risk Her2+ breast cancer following vaccination against Her2. J Transl Med. Sep 6, 2007;5:42.
    • (2007) J Transl Med , vol.5 , pp. 42
    • Morse, M.A.1    Hobeika, A.2    Osada, T.3
  • 14
    • 84859700438 scopus 로고    scopus 로고
    • Product Monograph Herceptin: Distributed By: Hoffmann-La Roche Limited, 2455 Meadowpine Boulevard, Mississauga, Ontario, L5N 6L7. Jan 6
    • Product Monograph Herceptin: Distributed By: Hoffmann-La Roche Limited, 2455 Meadowpine Boulevard, Mississauga, Ontario, L5N 6L7. Jan 6, 2012:1-75.
    • (2012) , pp. 1-75
  • 15
    • 17944379907 scopus 로고    scopus 로고
    • First-line herceptin monotherapy in metastatic breast cancer
    • Review
    • Vogel CL, Cobleigh MA, Tripathy D, et al. First-line herceptin monotherapy in metastatic breast cancer. Oncology. 2001;61(Suppl 2):37-42, Review.
    • (2001) Oncology , vol.61 , Issue.SUPPL. 2 , pp. 37-42
    • Vogel, C.L.1    Cobleigh, M.A.2    Tripathy, D.3
  • 16
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • Slamon DJ, Leyland-Jones B, Shak S, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med. 2001;344(11):783-792.
    • (2001) N Engl J Med , vol.344 , Issue.11 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3
  • 17
    • 22344446208 scopus 로고    scopus 로고
    • Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: The M77001 study group
    • Marty M, Cognetti F, Maraninchi D, et al. Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group. J Clin Oncol. 2005;23(19):4265-4274.
    • (2005) J Clin Oncol , vol.23 , Issue.19 , pp. 4265-4274
    • Marty, M.1    Cognetti, F.2    Maraninchi, D.3
  • 18
    • 33846477245 scopus 로고    scopus 로고
    • Randomized Phase II trial of weekly paclitaxel alone versus trastuzumab plus weekly paclitaxel as first-line therapy of patients with Her-2 positive advanced breast cancer
    • Gasparini G, Gion M, Mariani L, et al. Randomized Phase II trial of weekly paclitaxel alone versus trastuzumab plus weekly paclitaxel as first-line therapy of patients with Her-2 positive advanced breast cancer. Breast Cancer Res Treat. 2007;101:355e65.
    • (2007) Breast Cancer Res Treat , vol.101
    • Gasparini, G.1    Gion, M.2    Mariani, L.3
  • 19
    • 79951974161 scopus 로고    scopus 로고
    • Phase III randomized study comparing docetaxel plus trastuzumab with vinorelbine plus trastuzumab as first-line therapy of metastatic or locally advanced human epidermal growth factor receptor 2-positive breast cancer: The HERNATA Study
    • Andersson M, Lidbrink E, Bjerre K, et al. Phase III randomized study comparing docetaxel plus trastuzumab with vinorelbine plus trastuzumab as first-line therapy of metastatic or locally advanced human epidermal growth factor receptor 2-positive breast cancer: The HERNATA Study. J Clin Oncol. 2011;29(3):264-271.
    • (2011) J Clin Oncol , vol.29 , Issue.3 , pp. 264-271
    • Andersson, M.1    Lidbrink, E.2    Bjerre, K.3
  • 20
    • 33745530224 scopus 로고    scopus 로고
    • Randomized phase III study of trastuzumab, paclitaxel, and carboplatin compared with trastuzumab and paclitaxel in women with HER-2-overexpressing metastatic breast cancer
    • Robert N, Leyland-Jones B, Asmar L, et al. Randomized phase III study of trastuzumab, paclitaxel, and carboplatin compared with trastuzumab and paclitaxel in women with HER-2-overexpressing metastatic breast cancer. J Clin Oncol. 2006;24(18):2786-2792.
    • (2006) J Clin Oncol , vol.24 , Issue.18 , pp. 2786-2792
    • Robert, N.1    Leyland-Jones, B.2    Asmar, L.3
  • 21
    • 77949893849 scopus 로고    scopus 로고
    • Randomized phase II trial of first-line trastuzumab plus docetaxel and capecitabine compared with trastuzumab plus docetaxel in HER2-positive metastatic breast cancer
    • Wardley AM, Pivot X, Morales-Vasquez F, et al. Randomized phase II trial of first-line trastuzumab plus docetaxel and capecitabine compared with trastuzumab plus docetaxel in HER2-positive metastatic breast cancer. J Clin Oncol. 2010;28:976e83.
    • (2010) J Clin Oncol , vol.28
    • Wardley, A.M.1    Pivot, X.2    Morales-Vasquez, F.3
  • 22
    • 61749100246 scopus 로고    scopus 로고
    • Randomized study comparing efficacy/toxicity of monotherapy trastuzumab followed by monotherapy docetaxel at progression, and combination trastuzumab/ docetaxel as firstline chemotherapy in HER2-neu positive, metastatic breast cancer (MBC) (HERTAX study)
    • Bontenbal M, Seynaeve C, Stouthard J, et al. Randomized study comparing efficacy/toxicity of monotherapy trastuzumab followed by monotherapy docetaxel at progression, and combination trastuzumab/ docetaxel as firstline chemotherapy in HER2-neu positive, metastatic breast cancer (MBC) (HERTAX study). J Clin Oncol. 2008;26:1014.
    • (2008) J Clin Oncol , vol.26 , pp. 1014
    • Bontenbal, M.1    Seynaeve, C.2    Stouthard, J.3
  • 23
    • 0035873822 scopus 로고    scopus 로고
    • Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer
    • Burstein HJ, Kuter I, Campos SM, et al. Clinical activity of trastuzumab and vinorelbine in women with HER2-overexpressing metastatic breast cancer. J Clin Oncol. 2001;19(10):2722-2730.
    • (2001) J Clin Oncol , vol.19 , Issue.10 , pp. 2722-2730
    • Burstein, H.J.1    Kuter, I.2    Campos, S.M.3
  • 24
    • 3543091572 scopus 로고    scopus 로고
    • Phase II study of trastuzumab plus gemcitabine in chemotherapy-pretreated patients with metastatic breast cancer
    • O'Shaughnessy JA, Vukelja S, Marsland T, Kimmel G, Ratnam S, Pippen JE. Phase II study of trastuzumab plus gemcitabine in chemotherapy-pretreated patients with metastatic breast cancer. Clin Breast Cancer. 2004;5(2):142-147.
    • (2004) Clin Breast Cancer , vol.5 , Issue.2 , pp. 142-147
    • O'Shaughnessy, J.A.1    Vukelja, S.2    Marsland, T.3    Kimmel, G.4    Ratnam, S.5    Pippen, J.E.6
  • 25
    • 73949105921 scopus 로고    scopus 로고
    • Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: Results from the randomized phase III TAnDEM study
    • Kaufman B, Mackey JR, Clemens MR, et al. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study. J Clin Oncol. 2009;27(33):5529-5537.
    • (2009) J Clin Oncol , vol.27 , Issue.33 , pp. 5529-5537
    • Kaufman, B.1    Mackey, J.R.2    Clemens, M.R.3
  • 26
    • 84857095720 scopus 로고    scopus 로고
    • Higher efficacy of letrozole in combination with trastuzumab compared to letrozole monotherapy as first-line treatment in patients with HER2-positive, hormone-receptor-positive metastatic breast cancer-Results of the eLEcTRA trial
    • Huober J, Fasching PA, Barsoum M, et al. Higher efficacy of letrozole in combination with trastuzumab compared to letrozole monotherapy as first-line treatment in patients with HER2-positive, hormone-receptor-positive metastatic breast cancer-Results of the eLEcTRA trial. Breast. Aug 19, 2011.
    • (2011) Breast. Aug , pp. 19
    • Huober, J.1    Fasching, P.A.2    Barsoum, M.3
  • 27
    • 65349110371 scopus 로고    scopus 로고
    • Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: A German Breast Group 26/Breast International Group 03-05 Study
    • Von Minckwitz G, du Bois A, Schmidt M, et al. Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: A German Breast Group 26/Breast International Group 03-05 Study. J Clin Oncol. 2009;27(12):1999-2006.
    • (2009) J Clin Oncol , vol.27 , Issue.12 , pp. 1999-2006
    • von Minckwitz, G.1    du Bois, A.2    Schmidt, M.3
  • 28
    • 80053362290 scopus 로고    scopus 로고
    • On behalf of the GBG 26/ BIG 03-5 study group and participating investigators: Trastuzumab beyond progression: Overall survival analysis of the GBG 26/BIG 3-05 phase III study in HER2-positive breast cancer
    • Jul 7
    • Von Minckwitz G, Schwedler K, Schmidt M, et al. On behalf of the GBG 26/ BIG 03-5 study group and participating investigators: Trastuzumab beyond progression: Overall survival analysis of the GBG 26/BIG 3-05 phase III study in HER2-positive breast cancer. Eur J Cancer. Jul 7 2011:2273-2281.
    • (2011) Eur J Cancer , pp. 2273-2281
    • von Minckwitz, G.1    Schwedler, K.2    Schmidt, M.3
  • 29
    • 77949884661 scopus 로고    scopus 로고
    • Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
    • Blackwell KL, Burstein HJ, Storniolo AM, et al. Randomized study of lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J Clin Oncol. 2010;28(7):1124-1130.
    • (2010) J Clin Oncol , vol.28 , Issue.7 , pp. 1124-1130
    • Blackwell, K.L.1    Burstein, H.J.2    Storniolo, A.M.3
  • 30
    • 84862914692 scopus 로고    scopus 로고
    • Pertuzumab plus Trastuzumab plus Docetaxel for Metastatic Breast Cancer
    • Baselga J, Cortés J, Kim SB, et al. Pertuzumab plus Trastuzumab plus Docetaxel for Metastatic Breast Cancer. N Engl J Med. 2012;366(2):109-119.
    • (2012) N Engl J Med , vol.366 , Issue.2 , pp. 109-119
    • Baselga, J.1    Cortés, J.2    Kim, S.B.3
  • 31
    • 79952092706 scopus 로고    scopus 로고
    • Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy
    • Burris HA III, Rugo HS, Vukelja SJ, et al. Phase II study of the antibody drug conjugate trastuzumab-DM1 for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer after prior HER2-directed therapy. J Clin Oncol. 2011;29(4):398-405.
    • (2011) J Clin Oncol , vol.29 , Issue.4 , pp. 398-405
    • Burris III, H.A.1    Rugo, H.S.2    Vukelja, S.J.3
  • 32
    • 54349083317 scopus 로고    scopus 로고
    • The cost burden of trastuzumab and bevacizumab therapy for solid tumours in Canada
    • Jun
    • Drucker A, Skedgel C, Virik K, Rayson D, Sellon M, Younis T. The cost burden of trastuzumab and bevacizumab therapy for solid tumours in Canada. Curr Oncol. Jun 2008;15(3):136-142.
    • (2008) Curr Oncol , vol.15 , Issue.3 , pp. 136-142
    • Drucker, A.1    Skedgel, C.2    Virik, K.3    Rayson, D.4    Sellon, M.5    Younis, T.6
  • 33
    • 68649107614 scopus 로고    scopus 로고
    • Is trastuzumab a cost-effective treatment for breast cancer?
    • Oct
    • Younis T, Skedgel C. Is trastuzumab a cost-effective treatment for breast cancer? Expert Rev Pharmacoecon Outcomes Res. Oct 2008;8(5):433-442.
    • (2008) Expert Rev Pharmacoecon Outcomes Res , vol.8 , Issue.5 , pp. 433-442
    • Younis, T.1    Skedgel, C.2
  • 34
    • 84898690931 scopus 로고    scopus 로고
    • Guidance On the Use of Trastuzumab For the Treatment of Advanced Breast Cancer (TA 34 Guidance)
    • United Kingdom: National Institute for Health and Clinical Excellence (NICE), Available at, Accessed last January 20
    • United Kingdom: National Institute for Health and Clinical Excellence (NICE). Guidance on the use of trastuzumab for the treatment of advanced breast cancer (TA 34 Guidance). Available at: http://www.nice.org.uk/nicemedia/pdf/advancedbreastcancerno34PDF.pdf (Accessed last January 20, 2012).
    • (2012)
  • 35
    • 13544277897 scopus 로고    scopus 로고
    • Cost-effectiveness of herceptin: A standard cost model for breast-cancer treatment in a Belgian university hospital
    • Winter
    • Neyt MJ, Albrecht JA, Clarysse B, Cocquyt VF. Cost-effectiveness of herceptin: a standard cost model for breast-cancer treatment in a Belgian university hospital. Int J Technol Assess Health Care. Winter 2005;21(1):132-137.
    • (2005) Int J Technol Assess Health Care , vol.21 , Issue.1 , pp. 132-137
    • Neyt, M.J.1    Albrecht, J.A.2    Clarysse, B.3    Cocquyt, V.F.4
  • 36
    • 21344448824 scopus 로고    scopus 로고
    • A monoclonal antibody against HER-2 (trastuzumab) for metastatic breast cancer: A model-based cost-effectiveness analysis
    • Jun
    • Norum J, Risberg T, Olsen JA. A monoclonal antibody against HER-2 (trastuzumab) for metastatic breast cancer: a model-based cost-effectiveness analysis. Ann Oncol. Jun 2005;16(6):909-914.
    • (2005) Ann Oncol , vol.16 , Issue.6 , pp. 909-914
    • Norum, J.1    Risberg, T.2    Olsen, J.A.3
  • 37
    • 33846651627 scopus 로고    scopus 로고
    • Use of the monoclonal antibody antihuman epidermal growth factor receptor 2 (anti-HER2), trastuzumab, in the treatment of metastatic breast cancer: A cost-effectiveness analysis
    • Mar
    • Poncet B, Bachelot T, Colin C, et al. Use of the monoclonal antibody antihuman epidermal growth factor receptor 2 (anti-HER2), trastuzumab, in the treatment of metastatic breast cancer: a cost-effectiveness analysis. Clin Oncol (R Coll Radiol). Mar 2007;19(2):162-163.
    • (2007) Clin Oncol (R Coll Radiol) , vol.19 , Issue.2 , pp. 162-163
    • Poncet, B.1    Bachelot, T.2    Colin, C.3
  • 38
    • 55449105261 scopus 로고    scopus 로고
    • Use of the monoclonal antibody anti-HER2 trastuzumab in the treatment of metastatic breast cancer: A cost-effectiveness analysis
    • Aug
    • Poncet B, Bachelot T, Colin C, et al. Use of the monoclonal antibody anti-HER2 trastuzumab in the treatment of metastatic breast cancer: a cost-effectiveness analysis. Am J Clin Oncol. Aug 2008;31(4):363-368.
    • (2008) Am J Clin Oncol , vol.31 , Issue.4 , pp. 363-368
    • Poncet, B.1    Bachelot, T.2    Colin, C.3
  • 39
    • 70350651151 scopus 로고    scopus 로고
    • Cost-effectiveness Analysis of Trastuzumab (Herceptin) in HER2-Overexpressed Metastatic Breast Cancer
    • July 18
    • Perez-Ellis C, Goncalves A, Jacquemier J, et al. Cost-effectiveness Analysis of Trastuzumab (Herceptin) in HER2-Overexpressed Metastatic Breast Cancer. Am J Clin Oncol. July 18, 2009.
    • (2009) Am J Clin Oncol
    • Perez-Ellis, C.1    Goncalves, A.2    Jacquemier, J.3
  • 40
    • 84856333750 scopus 로고    scopus 로고
    • Lapatinib and trastuzumab in combination with an aromatase inhibitor for the first-line treatment of metastatic hormone receptor-positive breast cancer which over-expresses human epidermal growth factor 2 (HER2): A systematic review and economic analysis
    • iii-iv
    • Fleeman N, Bagust A, Boland A, et al. Lapatinib and trastuzumab in combination with an aromatase inhibitor for the first-line treatment of metastatic hormone receptor-positive breast cancer which over-expresses human epidermal growth factor 2 (HER2): a systematic review and economic analysis. Health Technol Assess. 2011;15(42):1-93, iii-iv.
    • (2011) Health Technol Assess , vol.15 , Issue.42 , pp. 1-93
    • Fleeman, N.1    Bagust, A.2    Boland, A.3
  • 42
    • 48149086257 scopus 로고    scopus 로고
    • Economic evaluations of medical care interventions for cancer patients: How, why, and what does it mean?
    • Jul-Aug
    • Shih YC, Halpern MT. Economic evaluations of medical care interventions for cancer patients: how, why, and what does it mean? CA Cancer J Clin. Jul-Aug 2008;58(4):231-244.
    • (2008) CA Cancer J Clin , vol.58 , Issue.4 , pp. 231-244
    • Shih, Y.C.1    Halpern, M.T.2
  • 43
    • 0034066723 scopus 로고    scopus 로고
    • Development of WHO guidelines on generalized cost-effectiveness analysis
    • Apr
    • Murray CJ, Evans DB, Acharya A, Baltussen RM. Development of WHO guidelines on generalized cost-effectiveness analysis. Health Econ. Apr 2000; 9(3):235-251.
    • (2000) Health Econ , vol.9 , Issue.3 , pp. 235-251
    • Murray, C.J.1    Evans, D.B.2    Acharya, A.3    Baltussen, R.M.4
  • 44
    • 0033914269 scopus 로고    scopus 로고
    • Willingness to pay for a quality-adjusted life year: In search of a standard
    • Jul-Sep
    • Hirth RA, Chernew ME, Miller E, Fendrick AM, Weissert WG. Willingness to pay for a quality-adjusted life year: in search of a standard. Med Decis Making. Jul-Sep 2000;20(3):332-342.
    • (2000) Med Decis Making , vol.20 , Issue.3 , pp. 332-342
    • Hirth, R.A.1    Chernew, M.E.2    Miller, E.3    Fendrick, A.M.4    Weissert, W.G.5
  • 46
    • 60049099370 scopus 로고    scopus 로고
    • Cost-effectiveness analysis of lapatinib in HER-2-positive advanced breast cancer
    • Feb 1
    • Le QA, Hay JW. Cost-effectiveness analysis of lapatinib in HER-2-positive advanced breast cancer. Cancer. Feb 1, 2009;115(3):489-498.
    • (2009) Cancer , vol.115 , Issue.3 , pp. 489-498
    • Le, Q.A.1    Hay, J.W.2
  • 47
    • 84865630545 scopus 로고    scopus 로고
    • Cost-effectiveness of lapatinib plus capecitabine in women with HER2+ metastatic breast cancer who have received prior therapy with trastuzumab
    • Jun 24
    • Delea TE, Tappenden P, Sofrygin O, et al. Cost-effectiveness of lapatinib plus capecitabine in women with HER2+ metastatic breast cancer who have received prior therapy with trastuzumab. Eur J Health Econ. Jun 24, 2011.
    • (2011) Eur J Health Econ
    • Delea, T.E.1    Tappenden, P.2    Sofrygin, O.3
  • 48
    • 84859707094 scopus 로고    scopus 로고
    • The economics of second line therapy with trastuzumab plus capecitabine or lapatinib plus capecitabine for Her2/neu positive metastatic breast cancer: Flip a coin?
    • Poster Presentation at the American Society of Clinical Oncology' 2009 Breast Cancer Symposium: San Francisco, CA, Oct, Abstract No 163
    • Younis T, Rayson D, Sellon M, Snow S, Skedgel C. The economics of second line therapy with trastuzumab plus capecitabine or lapatinib plus capecitabine for Her2/neu positive metastatic breast cancer: flip a coin? Poster Presentation at the American Society of Clinical Oncology' 2009 Breast Cancer Symposium: San Francisco, CA. Oct 2009 (Abstract No 163).
    • (2009)
    • Younis, T.1    Rayson, D.2    Sellon, M.3    Snow, S.4    Skedgel, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.