Cytochrome c end-capped mesoporous silica nanoparticles as redox-responsive drug delivery vehicles for liver tumor-targeted triplex therapy in vitro and in vivo

Journal of Controlled Release

Volumn 192, Issue , 2014, Pages 192-201

  Zhang, Beilu ^a   Luo, Zhong ^a   Liu, Junjie ^a   Ding, Xingwei ^a   Li, Jinghua ^a   Cai, Kaiyong ^a  

^a CHONGQING UNIVERSITY   (China)

Author keywords

Cytochrome c; In vivo; Mesoporous silica nanoparticles; Redox responsive delivery; Tumor targeted therapy

Indexed keywords

BIOCOMPATIBILITY; CELL DEATH; COVALENT BONDS; DRUG DELIVERY; ENZYME ACTIVITY; FLUORESCENCE SPECTROSCOPY; FOURIER TRANSFORM INFRARED SPECTROSCOPY; NANOTUBES; THERMOGRAVIMETRIC ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; TUMORS;

CYTOCHROME C; IN-VIVO; MESOPOROUS SILICA NANOPARTICLES; REDOX-RESPONSIVE; TUMOR-TARGETED THERAPY;

LOADING;

APTAMER; CETRIMIDE; CYTOCHROME C; DITHIOTHREITOL; DOXORUBICIN; DRUG VEHICLE; MESOPOROUS SILICA NANOPARTICLE; NANOCARRIER; SILICON DIOXIDE; SUCCINIC ANHYDRIDE; TETRAETHOXYSILANE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DELAYED RELEASE FORMULATION; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOCOMPATIBILITY; CANCER INHIBITION; CANCER THERAPY; CELL VIABILITY ASSAY; CELLULAR DISTRIBUTION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DISULFIDE BOND; DRUG DELIVERY SYSTEM; DRUG TARGETING; ENDOCYTOSIS; FLUORESCENCE SPECTROSCOPY; HEPG2 CELL LINE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; LIVER TUMOR; MOLECULARLY TARGETED THERAPY; MOUSE; NICK END LABELING; NONHUMAN; OXIDATION REDUCTION REACTION; PINOCYTOSIS; POROSITY; PRIORITY JOURNAL; PROTEIN CONTENT; THERAPY EFFECT; THERMOGRAVIMETRY; TRANSMISSION ELECTRON MICROSCOPY; TUMOR MICROENVIRONMENT; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECTS; LIVER; LIVER NEOPLASMS; NUDE MOUSE; PATHOLOGY; ULTRASTRUCTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APTAMERS, NUCLEOTIDE; CYTOCHROMES C; DELAYED-ACTION PREPARATIONS; DOXORUBICIN; DRUG DELIVERY SYSTEMS; HEP G2 CELLS; HUMANS; LIVER; LIVER NEOPLASMS; MICE, INBRED BALB C; MICE, NUDE; NANOPARTICLES; OXIDATION-REDUCTION; POROSITY; SILICON DIOXIDE;

EID: 84905593520     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.06.037     Document Type: Article

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