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Volumn 14, Issue 1, 2014, Pages

The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance

Author keywords

Cancer associated fibroblasts; Interstitial fluid pressure; Solid stress; Therapy resistance; Tumor microenvironment

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CXCR4; CISPLATIN; COLLAGEN; COLONY STIMULATING FACTOR 1; CYTOKINE; HYALURONIC ACID BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; STROMAL CELL DERIVED FACTOR 1; TUMOR NECROSIS FACTOR ALPHA;

EID: 84901493119     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/1475-2867-14-41     Document Type: Review
Times cited : (160)

References (110)
  • 1
    • 0035902141 scopus 로고    scopus 로고
    • The microenvironment of the tumour-host interface
    • 10.1038/35077241, 11357145
    • Liotta LA, Kohn EC. The microenvironment of the tumour-host interface. Nature 2001, 411:375-379. 10.1038/35077241, 11357145.
    • (2001) Nature , vol.411 , pp. 375-379
    • Liotta, L.A.1    Kohn, E.C.2
  • 2
    • 79956064263 scopus 로고    scopus 로고
    • Desmoplastic stromal reaction in papillary thyroid microcarcinoma
    • 10.1111/j.1365-2559.2011.03791.x, 21477259
    • Koperek O, Asari R, Niederle B, Kaserer K. Desmoplastic stromal reaction in papillary thyroid microcarcinoma. Histopathology 2011, 58:919-924. 10.1111/j.1365-2559.2011.03791.x, 21477259.
    • (2011) Histopathology , vol.58 , pp. 919-924
    • Koperek, O.1    Asari, R.2    Niederle, B.3    Kaserer, K.4
  • 3
    • 46349108651 scopus 로고    scopus 로고
    • Attenuated p53 activation in tumour-associated stromal cells accompanies decreased sensitivity to etoposide and vincristine
    • 10.1038/sj.bjc.6604465, 2453010,2453010, 18594537
    • Dudley AC, Shih SC, Cliffe AR, Hida K, Klagsbrun M. Attenuated p53 activation in tumour-associated stromal cells accompanies decreased sensitivity to etoposide and vincristine. Br J Cancer 2008, 99:118-125. 10.1038/sj.bjc.6604465, 2453010,2453010, 18594537.
    • (2008) Br J Cancer , vol.99 , pp. 118-125
    • Dudley, A.C.1    Shih, S.C.2    Cliffe, A.R.3    Hida, K.4    Klagsbrun, M.5
  • 4
    • 0034161922 scopus 로고    scopus 로고
    • Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells
    • Barcellos-Hoff MH, Ravani SA. Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res 2000, 60:1254-1260.
    • (2000) Cancer Res , vol.60 , pp. 1254-1260
    • Barcellos-Hoff, M.H.1    Ravani, S.A.2
  • 5
    • 0347302952 scopus 로고    scopus 로고
    • Cytokines in cancer pathogenesis and cancer therapy
    • 10.1038/nrc1252, 14708024
    • Dranoff G. Cytokines in cancer pathogenesis and cancer therapy. Nat Rev Cancer 2004, 4:11-22. 10.1038/nrc1252, 14708024.
    • (2004) Nat Rev Cancer , vol.4 , pp. 11-22
    • Dranoff, G.1
  • 6
    • 8144228952 scopus 로고    scopus 로고
    • Friends or foes - bipolar effects of the tumour stroma in cancer
    • 10.1038/nrc1477, 15516957
    • Mueller MM, Fusenig NE. Friends or foes - bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 2004, 4:839-849. 10.1038/nrc1477, 15516957.
    • (2004) Nat Rev Cancer , vol.4 , pp. 839-849
    • Mueller, M.M.1    Fusenig, N.E.2
  • 7
    • 70549112270 scopus 로고    scopus 로고
    • The angiogenic switch in carcinogenesis
    • 10.1016/j.semcancer.2009.05.003, 19482086
    • Baeriswyl V, Christofori G. The angiogenic switch in carcinogenesis. Semin Cancer Biol 2009, 19:329-337. 10.1016/j.semcancer.2009.05.003, 19482086.
    • (2009) Semin Cancer Biol , vol.19 , pp. 329-337
    • Baeriswyl, V.1    Christofori, G.2
  • 8
    • 19344363035 scopus 로고    scopus 로고
    • Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds
    • 10.1371/journal.pbio.0020007, 314300, 14737219
    • Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, Chi JT, van de Rijn M, Botstein D, Brown PO. Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS Biol 2004, 2:E7. 10.1371/journal.pbio.0020007, 314300, 14737219.
    • (2004) PLoS Biol , vol.2
    • Chang, H.Y.1    Sneddon, J.B.2    Alizadeh, A.A.3    Sood, R.4    West, R.B.5    Montgomery, K.6    Chi, J.T.7    van de Rijn, M.8    Botstein, D.9    Brown, P.O.10
  • 9
    • 33646384428 scopus 로고    scopus 로고
    • Fibroblasts in cancer
    • 10.1038/nrc1877, 16572188
    • Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer 2006, 6:392-401. 10.1038/nrc1877, 16572188.
    • (2006) Nat Rev Cancer , vol.6 , pp. 392-401
    • Kalluri, R.1    Zeisberg, M.2
  • 11
    • 84878114531 scopus 로고    scopus 로고
    • Stromal cells in tumor microenvironment and breast cancer
    • 10.1007/s10555-012-9415-3, 23114846
    • Mao Y, Keller ET, Garfield DH, Shen K, Wang J. Stromal cells in tumor microenvironment and breast cancer. Cancer Metastasis Rev 2013, 32:303-315. 10.1007/s10555-012-9415-3, 23114846.
    • (2013) Cancer Metastasis Rev , vol.32 , pp. 303-315
    • Mao, Y.1    Keller, E.T.2    Garfield, D.H.3    Shen, K.4    Wang, J.5
  • 12
    • 27944490875 scopus 로고    scopus 로고
    • VEGF as a therapeutic target in cancer
    • Ferrara N. VEGF as a therapeutic target in cancer. Oncology 2005, 69(Suppl 3):11-16.
    • (2005) Oncology , vol.69 , Issue.SUPPL. 3 , pp. 11-16
    • Ferrara, N.1
  • 14
    • 37349101054 scopus 로고    scopus 로고
    • Breast-cancer stromal cells with TP53 mutations and nodal metastases
    • 10.1056/NEJMoa071825, 18094375
    • Patocs A, Zhang L, Xu Y, Weber F, Caldes T, Mutter GL, Platzer P, Eng C. Breast-cancer stromal cells with TP53 mutations and nodal metastases. N Engl J Med 2007, 357:2543-2551. 10.1056/NEJMoa071825, 18094375.
    • (2007) N Engl J Med , vol.357 , pp. 2543-2551
    • Patocs, A.1    Zhang, L.2    Xu, Y.3    Weber, F.4    Caldes, T.5    Mutter, G.L.6    Platzer, P.7    Eng, C.8
  • 15
    • 0242298635 scopus 로고    scopus 로고
    • Tumor microenvironment and hemorheological abnormalities
    • Baronzio G, Freitas I, Kwaan HC. Tumor microenvironment and hemorheological abnormalities. Semin Thromb Hemost 2003, 29:489-497.
    • (2003) Semin Thromb Hemost , vol.29 , pp. 489-497
    • Baronzio, G.1    Freitas, I.2    Kwaan, H.C.3
  • 16
    • 0035835829 scopus 로고    scopus 로고
    • Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation
    • 10.1006/excr.2000.5133, 11237532
    • Elenbaas B, Weinberg RA. Heterotypic signaling between epithelial tumor cells and fibroblasts in carcinoma formation. Exp Cell Res 2001, 264:169-184. 10.1006/excr.2000.5133, 11237532.
    • (2001) Exp Cell Res , vol.264 , pp. 169-184
    • Elenbaas, B.1    Weinberg, R.A.2
  • 19
    • 0038148716 scopus 로고    scopus 로고
    • Molecular biology of prostate cancer
    • 10.1093/molehr/gag064, 12837920
    • Schulz WA, Burchardt M, Cronauer MV. Molecular biology of prostate cancer. Mol Hum Reprod 2003, 9:437-448. 10.1093/molehr/gag064, 12837920.
    • (2003) Mol Hum Reprod , vol.9 , pp. 437-448
    • Schulz, W.A.1    Burchardt, M.2    Cronauer, M.V.3
  • 20
    • 79959393938 scopus 로고    scopus 로고
    • Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies
    • 10.1146/annurev-chembioeng-061010-114300, 22432620
    • Chauhan VP, Stylianopoulos T, Boucher Y, Jain RK. Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies. Annu Rev Chem Biomol Eng 2011, 2:281-298. 10.1146/annurev-chembioeng-061010-114300, 22432620.
    • (2011) Annu Rev Chem Biomol Eng , vol.2 , pp. 281-298
    • Chauhan, V.P.1    Stylianopoulos, T.2    Boucher, Y.3    Jain, R.K.4
  • 21
    • 10944232632 scopus 로고    scopus 로고
    • Profiling molecular targets of TGF-beta1 in prostate fibroblast-to-myofibroblast transdifferentiation
    • 10.1016/j.mad.2004.09.023, 15610763
    • Untergasser G, Gander R, Lilg C, Lepperdinger G, Plas E, Berger P. Profiling molecular targets of TGF-beta1 in prostate fibroblast-to-myofibroblast transdifferentiation. Mech Ageing Dev 2005, 126:59-69. 10.1016/j.mad.2004.09.023, 15610763.
    • (2005) Mech Ageing Dev , vol.126 , pp. 59-69
    • Untergasser, G.1    Gander, R.2    Lilg, C.3    Lepperdinger, G.4    Plas, E.5    Berger, P.6
  • 22
    • 74549203484 scopus 로고    scopus 로고
    • IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients
    • 10.1186/1741-7015-8-1, 2823652, 20051100
    • Rajski M, Zanetti-Dallenbach R, Vogel B, Herrmann R, Rochlitz C, Buess M. IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients. BMC Med 2010, 8:1. 10.1186/1741-7015-8-1, 2823652, 20051100.
    • (2010) BMC Med , vol.8 , pp. 1
    • Rajski, M.1    Zanetti-Dallenbach, R.2    Vogel, B.3    Herrmann, R.4    Rochlitz, C.5    Buess, M.6
  • 23
    • 80054962098 scopus 로고    scopus 로고
    • Collagen triple helix repeat containing 1 protein, periostin and versican in primary and metastatic breast cancer: an immunohistochemical study
    • 10.1136/jclinpath-2011-200106, 21742751
    • Kharaishvili G, Cizkova M, Bouchalova K, Mgebrishvili G, Kolar Z, Bouchal J. Collagen triple helix repeat containing 1 protein, periostin and versican in primary and metastatic breast cancer: an immunohistochemical study. J Clin Pathol 2011, 64:977-982. 10.1136/jclinpath-2011-200106, 21742751.
    • (2011) J Clin Pathol , vol.64 , pp. 977-982
    • Kharaishvili, G.1    Cizkova, M.2    Bouchalova, K.3    Mgebrishvili, G.4    Kolar, Z.5    Bouchal, J.6
  • 24
    • 0037318744 scopus 로고    scopus 로고
    • Elevated serum periostin levels in patients with bone metastases from breast but not lung cancer
    • 10.1023/A:1021899904332, 12602924
    • Sasaki H, Yu CY, Dai M, Tam C, Loda M, Auclair D, Chen LB, Elias A. Elevated serum periostin levels in patients with bone metastases from breast but not lung cancer. Breast Cancer Res Treat 2003, 77:245-252. 10.1023/A:1021899904332, 12602924.
    • (2003) Breast Cancer Res Treat , vol.77 , pp. 245-252
    • Sasaki, H.1    Yu, C.Y.2    Dai, M.3    Tam, C.4    Loda, M.5    Auclair, D.6    Chen, L.B.7    Elias, A.8
  • 25
    • 3843095048 scopus 로고    scopus 로고
    • Extracellular S100A4(mts1) stimulates invasive growth of mouse endothelial cells and modulates MMP-13 matrix metalloproteinase activity
    • 10.1038/sj.onc.1207720, 15122322
    • Schmidt-Hansen B, Ornas D, Grigorian M, Klingelhofer J, Tulchinsky E, Lukanidin E, Ambartsumian N. Extracellular S100A4(mts1) stimulates invasive growth of mouse endothelial cells and modulates MMP-13 matrix metalloproteinase activity. Oncogene 2004, 23:5487-5495. 10.1038/sj.onc.1207720, 15122322.
    • (2004) Oncogene , vol.23 , pp. 5487-5495
    • Schmidt-Hansen, B.1    Ornas, D.2    Grigorian, M.3    Klingelhofer, J.4    Tulchinsky, E.5    Lukanidin, E.6    Ambartsumian, N.7
  • 28
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects
    • 10.1093/jnci/93.4.266, 11181773
    • Hockel M, Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 2001, 93:266-276. 10.1093/jnci/93.4.266, 11181773.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 29
    • 84857189202 scopus 로고    scopus 로고
    • Extracellular matrix players in metastatic niches
    • 10.1038/emboj.2011.469, 3261570, 22179697
    • Oskarsson T, Massague J. Extracellular matrix players in metastatic niches. EMBO J 2012, 31:254-256. 10.1038/emboj.2011.469, 3261570, 22179697.
    • (2012) EMBO J , vol.31 , pp. 254-256
    • Oskarsson, T.1    Massague, J.2
  • 31
    • 77956628008 scopus 로고    scopus 로고
    • Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture
    • 10.1016/j.stem.2010.03.020, 2917779, 20569694
    • Zeng YA, Nusse R. Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell 2010, 6:568-577. 10.1016/j.stem.2010.03.020, 2917779, 20569694.
    • (2010) Cell Stem Cell , vol.6 , pp. 568-577
    • Zeng, Y.A.1    Nusse, R.2
  • 32
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • 10.1038/nature03319, 15829953
    • Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005, 434:843-850. 10.1038/nature03319, 15829953.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 36
    • 80052429405 scopus 로고    scopus 로고
    • Identification of novel accessible proteins bearing diagnostic and therapeutic potential in human pancreatic ductal adenocarcinoma
    • 10.1021/pr200527z, 21755970
    • Turtoi A, Musmeci D, Wang Y, Dumont B, Somja J, Bevilacqua G, De Pauw E, Delvenne P, Castronovo V. Identification of novel accessible proteins bearing diagnostic and therapeutic potential in human pancreatic ductal adenocarcinoma. J Proteome Res 2011, 10:4302-4313. 10.1021/pr200527z, 21755970.
    • (2011) J Proteome Res , vol.10 , pp. 4302-4313
    • Turtoi, A.1    Musmeci, D.2    Wang, Y.3    Dumont, B.4    Somja, J.5    Bevilacqua, G.6    De Pauw, E.7    Delvenne, P.8    Castronovo, V.9
  • 37
    • 78650050458 scopus 로고    scopus 로고
    • Endothelial cells as key determinants of the tumor microenvironment: interaction with tumor cells, extracellular matrix and immune killer cells
    • 10.1615/CritRevImmunol.v30.i6.30, 21175416
    • Chouaib S, Kieda C, Benlalam H, Noman MZ, Mami-Chouaib F, Ruegg C. Endothelial cells as key determinants of the tumor microenvironment: interaction with tumor cells, extracellular matrix and immune killer cells. Crit Rev Immunol 2010, 30:529-545. 10.1615/CritRevImmunol.v30.i6.30, 21175416.
    • (2010) Crit Rev Immunol , vol.30 , pp. 529-545
    • Chouaib, S.1    Kieda, C.2    Benlalam, H.3    Noman, M.Z.4    Mami-Chouaib, F.5    Ruegg, C.6
  • 38
    • 84857857867 scopus 로고    scopus 로고
    • Candidate serum biomarkers for prostate adenocarcinoma identified by mRNA differences in prostate tissue and verified with protein measurements in tissue and blood
    • 10.1373/clinchem.2011.171637, 3951013, 22247499
    • Klee EW, Bondar OP, Goodmanson MK, Dyer RB, Erdogan S, Bergstralh EJ, Bergen HR, Sebo TJ, Klee GG. Candidate serum biomarkers for prostate adenocarcinoma identified by mRNA differences in prostate tissue and verified with protein measurements in tissue and blood. Clin Chem 2012, 58:599-609. 10.1373/clinchem.2011.171637, 3951013, 22247499.
    • (2012) Clin Chem , vol.58 , pp. 599-609
    • Klee, E.W.1    Bondar, O.P.2    Goodmanson, M.K.3    Dyer, R.B.4    Erdogan, S.5    Bergstralh, E.J.6    Bergen, H.R.7    Sebo, T.J.8    Klee, G.G.9
  • 39
    • 84857793831 scopus 로고    scopus 로고
    • Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate
    • 10.1038/onc.2011.312, 3307063, 21804603
    • Orr B, Riddick AC, Stewart GD, Anderson RA, Franco OE, Hayward SW, Thomson AA. Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate. Oncogene 2012, 31:1130-1142. 10.1038/onc.2011.312, 3307063, 21804603.
    • (2012) Oncogene , vol.31 , pp. 1130-1142
    • Orr, B.1    Riddick, A.C.2    Stewart, G.D.3    Anderson, R.A.4    Franco, O.E.5    Hayward, S.W.6    Thomson, A.A.7
  • 40
    • 0036843937 scopus 로고    scopus 로고
    • Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas
    • 10.1038/ng1013, 12379854
    • Kurose K, Gilley K, Matsumoto S, Watson PH, Zhou XP, Eng C. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat Genet 2002, 32:355-357. 10.1038/ng1013, 12379854.
    • (2002) Nat Genet , vol.32 , pp. 355-357
    • Kurose, K.1    Gilley, K.2    Matsumoto, S.3    Watson, P.H.4    Zhou, X.P.5    Eng, C.6
  • 41
    • 1942422179 scopus 로고    scopus 로고
    • Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression
    • 10.1128/MCB.24.9.3992-4003.2004, 387763, 15082792
    • Shao R, Bao S, Bai X, Blanchette C, Anderson RM, Dang T, Gishizky ML, Marks JR, Wang XF. Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Mol Cell Biol 2004, 24:3992-4003. 10.1128/MCB.24.9.3992-4003.2004, 387763, 15082792.
    • (2004) Mol Cell Biol , vol.24 , pp. 3992-4003
    • Shao, R.1    Bao, S.2    Bai, X.3    Blanchette, C.4    Anderson, R.M.5    Dang, T.6    Gishizky, M.L.7    Marks, J.R.8    Wang, X.F.9
  • 42
    • 80355123258 scopus 로고    scopus 로고
    • Appraising the current role of chemotherapy for the treatment of sarcoma
    • D'Adamo DR. Appraising the current role of chemotherapy for the treatment of sarcoma. Semin Oncol 2011, 38(Suppl 3):S19-S29.
    • (2011) Semin Oncol , vol.38 , Issue.SUPPL. 3
    • D'Adamo, D.R.1
  • 43
    • 60549103300 scopus 로고    scopus 로고
    • Highly variable response to cytotoxic chemotherapy in carcinoma-associated fibroblasts (CAFs) from lung and breast
    • 10.1186/1471-2407-8-364, 2626600, 19077243
    • Sonnenberg M, van der Kuip H, Haubeis S, Fritz P, Schroth W, Friedel G, Simon W, Murdter TE, Aulitzky WE. Highly variable response to cytotoxic chemotherapy in carcinoma-associated fibroblasts (CAFs) from lung and breast. BMC Cancer 2008, 8:364. 10.1186/1471-2407-8-364, 2626600, 19077243.
    • (2008) BMC Cancer , vol.8 , pp. 364
    • Sonnenberg, M.1    van der Kuip, H.2    Haubeis, S.3    Fritz, P.4    Schroth, W.5    Friedel, G.6    Simon, W.7    Murdter, T.E.8    Aulitzky, W.E.9
  • 44
    • 0035328628 scopus 로고    scopus 로고
    • N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells
    • Li G, Satyamoorthy K, Herlyn M. N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells. Cancer Res 2001, 61:3819-3825.
    • (2001) Cancer Res , vol.61 , pp. 3819-3825
    • Li, G.1    Satyamoorthy, K.2    Herlyn, M.3
  • 45
    • 77956472212 scopus 로고    scopus 로고
    • The role of the tissue microenvironment in the regulation of cancer cell motility and invasion
    • 10.1186/1478-811X-8-22, 2941745, 20822526
    • Brabek J, Mierke CT, Rosel D, Vesely P, Fabry B. The role of the tissue microenvironment in the regulation of cancer cell motility and invasion. Cell Commun Signal 2010, 8:22. 10.1186/1478-811X-8-22, 2941745, 20822526.
    • (2010) Cell Commun Signal , vol.8 , pp. 22
    • Brabek, J.1    Mierke, C.T.2    Rosel, D.3    Vesely, P.4    Fabry, B.5
  • 46
    • 68049083547 scopus 로고    scopus 로고
    • Random versus directionally persistent cell migration
    • 10.1038/nrm2729, 2752299, 19603038
    • Petrie RJ, Doyle AD, Yamada KM. Random versus directionally persistent cell migration. Nat Rev Mol Cell Biol 2009, 10:538-549. 10.1038/nrm2729, 2752299, 19603038.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 538-549
    • Petrie, R.J.1    Doyle, A.D.2    Yamada, K.M.3
  • 47
    • 84864924217 scopus 로고    scopus 로고
    • Controlling matrix stiffness and topography for the study of tumor cell migration
    • 10.4161/cam.21076, 3427241, 22863740
    • Kraning-Rush CM, Reinhart-King CA. Controlling matrix stiffness and topography for the study of tumor cell migration. Cell Adh Migr 2012, 6:274-279. 10.4161/cam.21076, 3427241, 22863740.
    • (2012) Cell Adh Migr , vol.6 , pp. 274-279
    • Kraning-Rush, C.M.1    Reinhart-King, C.A.2
  • 48
    • 33846293595 scopus 로고    scopus 로고
    • Probing the microenvironment of mammary tumors using multiphoton microscopy
    • 10.1007/s10911-006-9021-5, 17106644
    • Sidani M, Wyckoff J, Xue C, Segall JE, Condeelis J. Probing the microenvironment of mammary tumors using multiphoton microscopy. J Mammary Gland Biol Neoplasia 2006, 11:151-163. 10.1007/s10911-006-9021-5, 17106644.
    • (2006) J Mammary Gland Biol Neoplasia , vol.11 , pp. 151-163
    • Sidani, M.1    Wyckoff, J.2    Xue, C.3    Segall, J.E.4    Condeelis, J.5
  • 49
    • 0032529245 scopus 로고    scopus 로고
    • Identification of nonproliferating but viable hypoxic tumor cells in vivo
    • Durand RE, Raleigh JA. Identification of nonproliferating but viable hypoxic tumor cells in vivo. Cancer Res 1998, 58:3547-3550.
    • (1998) Cancer Res , vol.58 , pp. 3547-3550
    • Durand, R.E.1    Raleigh, J.A.2
  • 51
    • 84870355625 scopus 로고    scopus 로고
    • Host epithelial geometry regulates breast cancer cell invasiveness
    • 10.1073/pnas.1118872109, 3511712, 23150585
    • Boghaert E, Gleghorn JP, Lee K, Gjorevski N, Radisky DC, Nelson CM. Host epithelial geometry regulates breast cancer cell invasiveness. Proc Natl Acad Sci U S A 2012, 109:19632-19637. 10.1073/pnas.1118872109, 3511712, 23150585.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 19632-19637
    • Boghaert, E.1    Gleghorn, J.P.2    Lee, K.3    Gjorevski, N.4    Radisky, D.C.5    Nelson, C.M.6
  • 53
    • 5444219883 scopus 로고    scopus 로고
    • Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies
    • 10.1387/ijdb.041811af, 15349816
    • Folgueras AR, Pendas AM, Sanchez LM, Lopez-Otin C. Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies. Int J Dev Biol 2004, 48:411-424. 10.1387/ijdb.041811af, 15349816.
    • (2004) Int J Dev Biol , vol.48 , pp. 411-424
    • Folgueras, A.R.1    Pendas, A.M.2    Sanchez, L.M.3    Lopez-Otin, C.4
  • 54
    • 79958808952 scopus 로고    scopus 로고
    • How matrix properties control the self-assembly and maintenance of tissues
    • 10.1007/s10439-011-0310-9, 3419599, 21491153
    • Reinhart-King CA. How matrix properties control the self-assembly and maintenance of tissues. Ann Biomed Eng 2011, 39:1849-1856. 10.1007/s10439-011-0310-9, 3419599, 21491153.
    • (2011) Ann Biomed Eng , vol.39 , pp. 1849-1856
    • Reinhart-King, C.A.1
  • 56
    • 84858602107 scopus 로고    scopus 로고
    • Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
    • 10.1016/j.ccr.2012.01.007, 3371414, 22439937
    • Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell 2012, 21:418-429. 10.1016/j.ccr.2012.01.007, 3371414, 22439937.
    • (2012) Cancer Cell , vol.21 , pp. 418-429
    • Provenzano, P.P.1    Cuevas, C.2    Chang, A.E.3    Goel, V.K.4    Von Hoff, D.D.5    Hingorani, S.R.6
  • 59
    • 0026469519 scopus 로고
    • Adhesion molecules and tumor cell interaction with endothelium and subendothelial matrix
    • 10.1007/BF01307187, 1423822
    • Honn KV, Tang DG. Adhesion molecules and tumor cell interaction with endothelium and subendothelial matrix. Cancer Metastasis Rev 1992, 11:353-375. 10.1007/BF01307187, 1423822.
    • (1992) Cancer Metastasis Rev , vol.11 , pp. 353-375
    • Honn, K.V.1    Tang, D.G.2
  • 60
    • 0037111104 scopus 로고    scopus 로고
    • Prolonged hypoxia accelerates the posttranscriptional process of collagen synthesis in cultured fibroblasts
    • 10.1016/S0024-3205(02)02142-2, 12408871
    • Horino Y, Takahashi S, Miura T, Takahashi Y. Prolonged hypoxia accelerates the posttranscriptional process of collagen synthesis in cultured fibroblasts. Life Sci 2002, 71:3031-3045. 10.1016/S0024-3205(02)02142-2, 12408871.
    • (2002) Life Sci , vol.71 , pp. 3031-3045
    • Horino, Y.1    Takahashi, S.2    Miura, T.3    Takahashi, Y.4
  • 61
    • 23044499067 scopus 로고    scopus 로고
    • Distinct epigenetic changes in the stromal cells of breast cancers
    • 10.1038/ng1596, 16007089
    • Hu M, Yao J, Cai L, Bachman KE, van den Brule F, Velculescu V, Polyak K. Distinct epigenetic changes in the stromal cells of breast cancers. Nat Genet 2005, 37:899-905. 10.1038/ng1596, 16007089.
    • (2005) Nat Genet , vol.37 , pp. 899-905
    • Hu, M.1    Yao, J.2    Cai, L.3    Bachman, K.E.4    van den Brule, F.5    Velculescu, V.6    Polyak, K.7
  • 62
    • 0036849784 scopus 로고    scopus 로고
    • Environmental co-factors in HPV carcinogenesis
    • 10.1016/S0168-1702(02)00188-0, 12445659
    • Castellsague X, Bosch FX, Munoz N. Environmental co-factors in HPV carcinogenesis. Virus Res 2002, 89:191-199. 10.1016/S0168-1702(02)00188-0, 12445659.
    • (2002) Virus Res , vol.89 , pp. 191-199
    • Castellsague, X.1    Bosch, F.X.2    Munoz, N.3
  • 63
    • 0036402142 scopus 로고    scopus 로고
    • The diet, prostate inflammation, and the development of prostate cancer
    • 10.1023/A:1020110718701, 12400993
    • Nelson WG, DeWeese TL, DeMarzo AM. The diet, prostate inflammation, and the development of prostate cancer. Cancer Metastasis Rev 2002, 21:3-16. 10.1023/A:1020110718701, 12400993.
    • (2002) Cancer Metastasis Rev , vol.21 , pp. 3-16
    • Nelson, W.G.1    DeWeese, T.L.2    DeMarzo, A.M.3
  • 64
    • 31544441610 scopus 로고    scopus 로고
    • Distinct role of macrophages in different tumor microenvironments
    • 10.1158/0008-5472.CAN-05-4005, 16423985
    • Lewis CE, Pollard JW. Distinct role of macrophages in different tumor microenvironments. Cancer Res 2006, 66:605-612. 10.1158/0008-5472.CAN-05-4005, 16423985.
    • (2006) Cancer Res , vol.66 , pp. 605-612
    • Lewis, C.E.1    Pollard, J.W.2
  • 65
    • 23044457914 scopus 로고    scopus 로고
    • Antibodies against macrophages that overlap in specificity with fibroblasts
    • 10.1111/j.1523-1755.2005.00358.x, 15882296
    • Inoue T, Plieth D, Venkov CD, Xu C, Neilson EG. Antibodies against macrophages that overlap in specificity with fibroblasts. Kidney Int 2005, 67:2488-2493. 10.1111/j.1523-1755.2005.00358.x, 15882296.
    • (2005) Kidney Int , vol.67 , pp. 2488-2493
    • Inoue, T.1    Plieth, D.2    Venkov, C.D.3    Xu, C.4    Neilson, E.G.5
  • 67
    • 34447258681 scopus 로고    scopus 로고
    • Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize
    • 10.1002/jcb.21187, 17171643
    • Fukumura D, Jain RK. Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize. J Cell Biochem 2007, 101:937-949. 10.1002/jcb.21187, 17171643.
    • (2007) J Cell Biochem , vol.101 , pp. 937-949
    • Fukumura, D.1    Jain, R.K.2
  • 68
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • 10.1038/nrc1187, 13130303
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003, 3:721-732. 10.1038/nrc1187, 13130303.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 69
    • 5444248307 scopus 로고    scopus 로고
    • Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac
    • De Wever O, Nguyen QD, Van Hoorde L, Bracke M, Bruyneel E, Gespach C, Mareel M. Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac. FASEB J 2004, 18:1016-1018.
    • (2004) FASEB J , vol.18 , pp. 1016-1018
    • De Wever, O.1    Nguyen, Q.D.2    Van Hoorde, L.3    Bracke, M.4    Bruyneel, E.5    Gespach, C.6    Mareel, M.7
  • 70
    • 58149267580 scopus 로고    scopus 로고
    • Corrupt policemen: inflammatory cells promote tumor angiogenesis
    • 10.1097/CCO.0b013e32831bed7e, 19125020
    • Zumsteg A, Christofori G. Corrupt policemen: inflammatory cells promote tumor angiogenesis. Curr Opin Oncol 2009, 21:60-70. 10.1097/CCO.0b013e32831bed7e, 19125020.
    • (2009) Curr Opin Oncol , vol.21 , pp. 60-70
    • Zumsteg, A.1    Christofori, G.2
  • 71
    • 38449112889 scopus 로고    scopus 로고
    • The role of chemokines in neutrophil biology
    • 10.2741/2853, 17981721
    • Kobayashi Y. The role of chemokines in neutrophil biology. Front Biosci 2008, 13:2400-2407. 10.2741/2853, 17981721.
    • (2008) Front Biosci , vol.13 , pp. 2400-2407
    • Kobayashi, Y.1
  • 72
    • 78649767464 scopus 로고    scopus 로고
    • Reciprocal activation of macrophages and breast carcinoma cells by nitric oxide and colony-stimulating factor-1
    • 10.1093/carcin/bgq172, 20876703
    • Lin CW, Shen SC, Ko CH, Lin HY, Chen YC. Reciprocal activation of macrophages and breast carcinoma cells by nitric oxide and colony-stimulating factor-1. Carcinogenesis 2010, 31:2039-2048. 10.1093/carcin/bgq172, 20876703.
    • (2010) Carcinogenesis , vol.31 , pp. 2039-2048
    • Lin, C.W.1    Shen, S.C.2    Ko, C.H.3    Lin, H.Y.4    Chen, Y.C.5
  • 73
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • 10.1038/nature01322, 2803035, 12490959
    • Coussens LM, Werb Z. Inflammation and cancer. Nature 2002, 420:860-867. 10.1038/nature01322, 2803035, 12490959.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 74
    • 3042822267 scopus 로고    scopus 로고
    • Cancer and the chemokine network
    • 10.1038/nrc1388, 15229479
    • Balkwill F. Cancer and the chemokine network. Nat Rev Cancer 2004, 4:540-550. 10.1038/nrc1388, 15229479.
    • (2004) Nat Rev Cancer , vol.4 , pp. 540-550
    • Balkwill, F.1
  • 75
    • 33746433462 scopus 로고    scopus 로고
    • The fibroblastic coconspirator in cancer progression
    • 10.1101/sqb.2005.70.007, 2580828, 16869775
    • Egeblad M, Littlepage LE, Werb Z. The fibroblastic coconspirator in cancer progression. Cold Spring Harb Symp Quant Biol 2005, 70:383-388. 10.1101/sqb.2005.70.007, 2580828, 16869775.
    • (2005) Cold Spring Harb Symp Quant Biol , vol.70 , pp. 383-388
    • Egeblad, M.1    Littlepage, L.E.2    Werb, Z.3
  • 76
    • 33646428091 scopus 로고    scopus 로고
    • Normal stem cells and cancer stem cells: the niche matters
    • 10.1158/0008-5472.CAN-05-3986, 16651403
    • Li L, Neaves WB. Normal stem cells and cancer stem cells: the niche matters. Cancer Res 2006, 66:4553-4557. 10.1158/0008-5472.CAN-05-3986, 16651403.
    • (2006) Cancer Res , vol.66 , pp. 4553-4557
    • Li, L.1    Neaves, W.B.2
  • 77
    • 0037163738 scopus 로고    scopus 로고
    • The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis
    • 10.1038/sj.bjc.6600551, 2364252, 12232748
    • Meert AP, Paesmans M, Martin B, Delmotte P, Berghmans T, Verdebout JM, Lafitte JJ, Mascaux C, Sculier JP. The role of microvessel density on the survival of patients with lung cancer: a systematic review of the literature with meta-analysis. Br J Cancer 2002, 87:694-701. 10.1038/sj.bjc.6600551, 2364252, 12232748.
    • (2002) Br J Cancer , vol.87 , pp. 694-701
    • Meert, A.P.1    Paesmans, M.2    Martin, B.3    Delmotte, P.4    Berghmans, T.5    Verdebout, J.M.6    Lafitte, J.J.7    Mascaux, C.8    Sculier, J.P.9
  • 78
    • 70149115254 scopus 로고    scopus 로고
    • Tumor-endothelial interaction links the CD44(+)/CD24(-) phenotype with poor prognosis in early-stage breast cancer
    • 2745665, 19794958
    • Buess M, Rajski M, Vogel-Durrer BM, Herrmann R, Rochlitz C. Tumor-endothelial interaction links the CD44(+)/CD24(-) phenotype with poor prognosis in early-stage breast cancer. Neoplasia 2009, 11:987-1002. 2745665, 19794958.
    • (2009) Neoplasia , vol.11 , pp. 987-1002
    • Buess, M.1    Rajski, M.2    Vogel-Durrer, B.M.3    Herrmann, R.4    Rochlitz, C.5
  • 79
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fluid pressure - an obstacle in cancer therapy
    • 10.1038/nrc1456, 15510161
    • Heldin CH, Rubin K, Pietras K, Ostman A. High interstitial fluid pressure - an obstacle in cancer therapy. Nat Rev Cancer 2004, 4:806-813. 10.1038/nrc1456, 15510161.
    • (2004) Nat Rev Cancer , vol.4 , pp. 806-813
    • Heldin, C.H.1    Rubin, K.2    Pietras, K.3    Ostman, A.4
  • 80
    • 79955929967 scopus 로고    scopus 로고
    • Nestin in gastrointestinal and other cancers: effects on cells and tumor angiogenesis
    • 10.3748/wjg.v17.i4.409, 3027007, 21274370
    • Ishiwata T, Matsuda Y, Naito Z. Nestin in gastrointestinal and other cancers: effects on cells and tumor angiogenesis. World J Gastroenterol 2011, 17:409-418. 10.3748/wjg.v17.i4.409, 3027007, 21274370.
    • (2011) World J Gastroenterol , vol.17 , pp. 409-418
    • Ishiwata, T.1    Matsuda, Y.2    Naito, Z.3
  • 82
    • 34247629605 scopus 로고    scopus 로고
    • A novel myoepithelial/progenitor cell marker in the breast?
    • 10.1007/s00428-007-0403-x, 17429688
    • Kolar Z, Ehrmann J, Turashvili G, Bouchal J, Mokry J. A novel myoepithelial/progenitor cell marker in the breast?. Virchows Arch 2007, 450:607-609. 10.1007/s00428-007-0403-x, 17429688.
    • (2007) Virchows Arch , vol.450 , pp. 607-609
    • Kolar, Z.1    Ehrmann, J.2    Turashvili, G.3    Bouchal, J.4    Mokry, J.5
  • 83
    • 58949092790 scopus 로고    scopus 로고
    • The tumor microenvironment and metastatic disease
    • 10.1007/s10585-008-9182-2, 18543068
    • Lunt SJ, Chaudary N, Hill RP. The tumor microenvironment and metastatic disease. Clin Exp Metastasis 2009, 26:19-34. 10.1007/s10585-008-9182-2, 18543068.
    • (2009) Clin Exp Metastasis , vol.26 , pp. 19-34
    • Lunt, S.J.1    Chaudary, N.2    Hill, R.P.3
  • 84
    • 18144412747 scopus 로고    scopus 로고
    • Suppression of tumor development and metastasis formation in mice lacking the S100A4(mts1) gene
    • 10.1158/0008-5472.CAN-04-4510, 15867373
    • Grum-Schwensen B, Klingelhofer J, Berg CH, El-Naaman C, Grigorian M, Lukanidin E, Ambartsumian N. Suppression of tumor development and metastasis formation in mice lacking the S100A4(mts1) gene. Cancer Res 2005, 65:3772-3780. 10.1158/0008-5472.CAN-04-4510, 15867373.
    • (2005) Cancer Res , vol.65 , pp. 3772-3780
    • Grum-Schwensen, B.1    Klingelhofer, J.2    Berg, C.H.3    El-Naaman, C.4    Grigorian, M.5    Lukanidin, E.6    Ambartsumian, N.7
  • 85
    • 0018862719 scopus 로고
    • On the nature of the radiobiologically hypoxic fraction in tumors
    • 10.1016/0360-3016(80)90215-1, 6988374
    • Sutherland RM, Franko AJ. On the nature of the radiobiologically hypoxic fraction in tumors. Int J Radiat Oncol Biol Phys 1980, 6:117-120. 10.1016/0360-3016(80)90215-1, 6988374.
    • (1980) Int J Radiat Oncol Biol Phys , vol.6 , pp. 117-120
    • Sutherland, R.M.1    Franko, A.J.2
  • 87
    • 34547960734 scopus 로고    scopus 로고
    • Analysis of gene expression in the tumor-associated macrophage
    • 10.1016/j.jss.2006.12.542, 17597158
    • Duff MD, Mestre J, Maddali S, Yan ZP, Stapleton P, Daly JM. Analysis of gene expression in the tumor-associated macrophage. J Surg Res 2007, 142:119-128. 10.1016/j.jss.2006.12.542, 17597158.
    • (2007) J Surg Res , vol.142 , pp. 119-128
    • Duff, M.D.1    Mestre, J.2    Maddali, S.3    Yan, Z.P.4    Stapleton, P.5    Daly, J.M.6
  • 88
    • 0036554644 scopus 로고    scopus 로고
    • Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism
    • Helmlinger G, Sckell A, Dellian M, Forbes NS, Jain RK. Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism. Clin Cancer Res 2002, 8:1284-1291.
    • (2002) Clin Cancer Res , vol.8 , pp. 1284-1291
    • Helmlinger, G.1    Sckell, A.2    Dellian, M.3    Forbes, N.S.4    Jain, R.K.5
  • 89
    • 79955870488 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts and their putative role in potentiating the initiation and development of epithelial ovarian cancer
    • 3084616, 21532880
    • Schauer IG, Sood AK, Mok S, Liu J. Cancer-associated fibroblasts and their putative role in potentiating the initiation and development of epithelial ovarian cancer. Neoplasia 2011, 13:393-405. 3084616, 21532880.
    • (2011) Neoplasia , vol.13 , pp. 393-405
    • Schauer, I.G.1    Sood, A.K.2    Mok, S.3    Liu, J.4
  • 90
    • 70450225616 scopus 로고    scopus 로고
    • Endosialin: from vascular target to biomarker for human sarcomas
    • 10.2217/bmm.09.54, 20477527
    • Bagley RG. Endosialin: from vascular target to biomarker for human sarcomas. Biomark Med 2009, 3:589-604. 10.2217/bmm.09.54, 20477527.
    • (2009) Biomark Med , vol.3 , pp. 589-604
    • Bagley, R.G.1
  • 91
    • 67349114001 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition
    • 10.1038/ki.2009.62, 19279556
    • Sun S, Ning X, Zhang Y, Lu Y, Nie Y, Han S, Liu L, Du R, Xia L, He L, Fan D. Hypoxia-inducible factor-1alpha induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition. Kidney Int 2009, 75:1278-1287. 10.1038/ki.2009.62, 19279556.
    • (2009) Kidney Int , vol.75 , pp. 1278-1287
    • Sun, S.1    Ning, X.2    Zhang, Y.3    Lu, Y.4    Nie, Y.5    Han, S.6    Liu, L.7    Du, R.8    Xia, L.9    He, L.10    Fan, D.11
  • 92
    • 34247527730 scopus 로고    scopus 로고
    • Hypoxia-inducible factors, stem cells, and cancer
    • 10.1016/j.cell.2007.04.019, 3150586, 17482542
    • Keith B, Simon MC. Hypoxia-inducible factors, stem cells, and cancer. Cell 2007, 129:465-472. 10.1016/j.cell.2007.04.019, 3150586, 17482542.
    • (2007) Cell , vol.129 , pp. 465-472
    • Keith, B.1    Simon, M.C.2
  • 93
    • 84863012236 scopus 로고    scopus 로고
    • Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer
    • 10.1158/1078-0432.CCR-11-1980, 22184053
    • Sun JD, Liu Q, Wang J, Ahluwalia D, Ferraro D, Wang Y, Duan JX, Ammons WS, Curd JG, Matteucci MD, Hart CP. Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer. Clin Cancer Res 2012, 18:758-770. 10.1158/1078-0432.CCR-11-1980, 22184053.
    • (2012) Clin Cancer Res , vol.18 , pp. 758-770
    • Sun, J.D.1    Liu, Q.2    Wang, J.3    Ahluwalia, D.4    Ferraro, D.5    Wang, Y.6    Duan, J.X.7    Ammons, W.S.8    Curd, J.G.9    Matteucci, M.D.10    Hart, C.P.11
  • 94
    • 0025083528 scopus 로고
    • Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers
    • 10.1073/pnas.87.18.7235, 54718, 2402505
    • Garin-Chesa P, Old LJ, Rettig WJ. Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers. Proc Natl Acad Sci U S A 1990, 87:7235-7239. 10.1073/pnas.87.18.7235, 54718, 2402505.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 7235-7239
    • Garin-Chesa, P.1    Old, L.J.2    Rettig, W.J.3
  • 95
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • 10.1038/nature04871, 16724055
    • Pouyssegur J, Dayan F, Mazure NM. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 2006, 441:437-443. 10.1038/nature04871, 16724055.
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouyssegur, J.1    Dayan, F.2    Mazure, N.M.3
  • 96
    • 0037192802 scopus 로고    scopus 로고
    • Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF
    • 10.1074/jbc.M108347200, 11741977
    • Xu L, Fukumura D, Jain RK. Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF. J Biol Chem 2002, 277:11368-11374. 10.1074/jbc.M108347200, 11741977.
    • (2002) J Biol Chem , vol.277 , pp. 11368-11374
    • Xu, L.1    Fukumura, D.2    Jain, R.K.3
  • 97
    • 58849126879 scopus 로고    scopus 로고
    • Three-dimensional context regulation of metastasis
    • 10.1007/s10585-008-9209-8, 2648515, 18814043
    • Erler JT, Weaver VM. Three-dimensional context regulation of metastasis. Clin Exp Metastasis 2009, 26:35-49. 10.1007/s10585-008-9209-8, 2648515, 18814043.
    • (2009) Clin Exp Metastasis , vol.26 , pp. 35-49
    • Erler, J.T.1    Weaver, V.M.2
  • 98
    • 0028475568 scopus 로고
    • Interstitial fluid pressure in breast cancer, benign breast conditions, and breast parenchyma
    • 10.1007/BF03187139, 7850532
    • Nathanson SD, Nelson L. Interstitial fluid pressure in breast cancer, benign breast conditions, and breast parenchyma. Ann Surg Oncol 1994, 1:333-338. 10.1007/BF03187139, 7850532.
    • (1994) Ann Surg Oncol , vol.1 , pp. 333-338
    • Nathanson, S.D.1    Nelson, L.2
  • 99
    • 0035417889 scopus 로고    scopus 로고
    • Interstitial fluid pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor oxygen measurements
    • Milosevic M, Fyles A, Hedley D, Pintilie M, Levin W, Manchul L, Hill R. Interstitial fluid pressure predicts survival in patients with cervix cancer independent of clinical prognostic factors and tumor oxygen measurements. Cancer Res 2001, 61:6400-6405.
    • (2001) Cancer Res , vol.61 , pp. 6400-6405
    • Milosevic, M.1    Fyles, A.2    Hedley, D.3    Pintilie, M.4    Levin, W.5    Manchul, L.6    Hill, R.7
  • 100
    • 12144287046 scopus 로고    scopus 로고
    • Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance
    • 10.1128/MCB.24.7.2875-2889.2004, 371100, 15024076
    • Erler JT, Cawthorne CJ, Williams KJ, Koritzinsky M, Wouters BG, Wilson C, Miller C, Demonacos C, Stratford IJ, Dive C. Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Mol Cell Biol 2004, 24:2875-2889. 10.1128/MCB.24.7.2875-2889.2004, 371100, 15024076.
    • (2004) Mol Cell Biol , vol.24 , pp. 2875-2889
    • Erler, J.T.1    Cawthorne, C.J.2    Williams, K.J.3    Koritzinsky, M.4    Wouters, B.G.5    Wilson, C.6    Miller, C.7    Demonacos, C.8    Stratford, I.J.9    Dive, C.10
  • 101
    • 39549099076 scopus 로고    scopus 로고
    • Interstitial fluid pressure, vascularity and metastasis in ectopic, orthotopic and spontaneous tumours
    • 10.1186/1471-2407-8-2, 2245966, 18179711
    • Lunt SJ, Kalliomaki TM, Brown A, Yang VX, Milosevic M, Hill RP. Interstitial fluid pressure, vascularity and metastasis in ectopic, orthotopic and spontaneous tumours. BMC Cancer 2008, 8:2. 10.1186/1471-2407-8-2, 2245966, 18179711.
    • (2008) BMC Cancer , vol.8 , pp. 2
    • Lunt, S.J.1    Kalliomaki, T.M.2    Brown, A.3    Yang, V.X.4    Milosevic, M.5    Hill, R.P.6
  • 102
    • 34047260282 scopus 로고    scopus 로고
    • Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model
    • 10.1158/0008-5472.CAN-06-4102, 3022341, 17363594
    • Jain RK, Tong RT, Munn LL. Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. Cancer Res 2007, 67:2729-2735. 10.1158/0008-5472.CAN-06-4102, 3022341, 17363594.
    • (2007) Cancer Res , vol.67 , pp. 2729-2735
    • Jain, R.K.1    Tong, R.T.2    Munn, L.L.3
  • 105
    • 0034662608 scopus 로고    scopus 로고
    • Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation
    • Leu AJ, Berk DA, Lymboussaki A, Alitalo K, Jain RK. Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation. Cancer Res 2000, 60:4324-4327.
    • (2000) Cancer Res , vol.60 , pp. 4324-4327
    • Leu, A.J.1    Berk, D.A.2    Lymboussaki, A.3    Alitalo, K.4    Jain, R.K.5
  • 106
    • 0035881307 scopus 로고    scopus 로고
    • Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
    • Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain RK. Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Res 2001, 61:6020-6024.
    • (2001) Cancer Res , vol.61 , pp. 6020-6024
    • Fukumura, D.1    Xu, L.2    Chen, Y.3    Gohongi, T.4    Seed, B.5    Jain, R.K.6
  • 107
    • 35348839617 scopus 로고    scopus 로고
    • Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma
    • 10.1073/pnas.0702014104, 1955775, 17715296
    • Oldberg A, Kalamajski S, Salnikov AV, Stuhr L, Morgelin M, Reed RK, Heldin NE, Rubin K. Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma. Proc Natl Acad Sci U S A 2007, 104:13966-13971. 10.1073/pnas.0702014104, 1955775, 17715296.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 13966-13971
    • Oldberg, A.1    Kalamajski, S.2    Salnikov, A.V.3    Stuhr, L.4    Morgelin, M.5    Reed, R.K.6    Heldin, N.E.7    Rubin, K.8
  • 108
    • 0026348691 scopus 로고
    • Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response
    • Roh HD, Boucher Y, Kalnicki S, Buchsbaum R, Bloomer WD, Jain RK. Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response. Cancer Res 1991, 51:6695-6698.
    • (1991) Cancer Res , vol.51 , pp. 6695-6698
    • Roh, H.D.1    Boucher, Y.2    Kalnicki, S.3    Buchsbaum, R.4    Bloomer, W.D.5    Jain, R.K.6
  • 110


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