In vivo SELEX for identification of brain-penetrating aptamers

Molecular Therapy Nucleic Acids

Volumn 2, Issue , 2013, Pages e67-

  Cheng, Congsheng ^a   Chen, Yong Hong ^a   Lennox, Kim A ^b   Behlke, Mark A ^b   Davidson, Beverly L ^a  

^a UNIVERSITY OF IOWA   (United States)

^b INTEGRATED DNA TECHNOLOGIES   (United States)

Author keywords

Blood brain barrier; In vivo selection; Mouse; RNA

Indexed keywords

APTAMER;

ANIMAL CELL; ARTICLE; BACTERIOPHAGE; BIOPANNING; BLOOD VESSEL; BRAIN CAPILLARY; CAPILLARY ENDOTHELIUM; CONTROLLED STUDY; CONVERGENT EVOLUTION; INFORMATION SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT;

EID: 84878869042     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1038/mtna.2012.59     Document Type: Article

References (42)

1. de Boer, AG and Gaillard, PJ (2007). Drug targeting to the brain. Annu Rev Pharmacol Toxicol 47: 323-355.
2. Chen, Y, and Liu, L (2012). Modern methods for delivery of drugs across the blood-brain barrier. Adv Drug Deliv Rev 64: 640-665.
3. Pardridge, WM (1999). Blood-brain barrier biology and methodology. J Neurovirol 5: 556-569. (Pubitemid 30032082)
4. Pavan, B, Dalpiaz, A, Ciliberti, N, Biondi, C, Manfredini, S and Vertuani, S (2008). Progress in drug delivery to the central nervous system by the prodrug approach. Molecules 13: 1035-1065.
5. Davidson, BL and Breakefield, XO (2003). Viral vectors for gene delivery to the nervous system. Nat Rev Neurosci 4: 353-364. (Pubitemid 37280174)
6. Zhou, J, Swiderski, P, Li, H, Zhang, J, Neff, CP, Akkina, R et al. (2009). Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells. Nucleic Acids Res 37: 3094-3109.
7. Proske, D, Blank, M, Buhmann, R and Resch, A (2005). Aptamers-basic research, drug development, and clinical applications. Appl Microbiol Biotechnol 69: 367-374. (Pubitemid 41737059)
8. Keefe, AD, Pai, S and Ellington, A (2010). Aptamers as therapeutics. Nat Rev Drug Discov 9: 537-550.
9. Tuerk, C and Gold, L (1990). Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249: 505-510.
10. Ellington, AD and Szostak, JW (1990). In vitro selection of RNA molecules that bind specific ligands. Nature 346: 818-822.
11. Lassalle, HP, Marchal, S, Guillemin, F, Reinhard, A and Bezdetnaya, L (2012). Aptamers as remarkable diagnostic and therapeutic agents in cancer treatment. Curr Drug Metab 13: 1130-1144.
12. Wheeler, LA, Trifonova, R, Vrbanac, V, Basar, E, McKernan, S, Xu, Z et al. (2011). Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras. J Clin Invest 121: 2401-2412.
13. Dua, P, Kim, S and Lee, DK (2011). Nucleic acid aptamers targeting cell-surface proteins. Methods 54: 215-225.
14. Lupold, SE, Hicke, BJ, Lin, Y and Coffey, DS (2002). Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostatespecific membrane antigen. Cancer Res 62: 4029-4033. (Pubitemid 34791070)
15. Shangguan, D, Li, Y, Tang, Z, Cao, ZC, Chen, HW, Mallikaratchy, P et al. (2006). Aptamers evolved from live cells as effective molecular probes for cancer study. Proc Natl Acad Sci USA 103: 11838-11843. (Pubitemid 44215773)
16. Mi, J, Liu, Y, Rabbani, ZN, Yang, Z, Urban, JH, Sullenger, BA et al. (2010). In vivo selection of tumor-targeting RNA motifs. Nat Chem Biol 6: 22-24.
17. Healy, JM, Lewis, SD, Kurz, M, Boomer, RM, Thompson, KM, Wilson, C et al. (2004). Pharmacokinetics and biodistribution of novel aptamer compositions. Pharm Res 21: 2234-2246. (Pubitemid 40568437)
18. Zuker, M (2003). Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 31: 3406-3415. (Pubitemid 37442169)
19. Daquinag, AC, Zhang, Y, Amaya-Manzanares, F, Simmons, PJ and Kolonin, MG (2011). An isoform of decorin is a resistin receptor on the surface of adipose progenitor cells. Cell Stem Cell 9: 74-86.
20. Cecchelli, R, Berezowski, V, Lundquist, S, Culot, M, Renftel, M, Dehouck, MP et al. (2007). Modelling of the blood-brain barrier in drug discovery and development. Nat Rev Drug Discov 6: 650-661. (Pubitemid 47202487)
21. Pardridge, WM (2010). Biopharmaceutical drug targeting to the brain. J Drug Target 18: 157-167.
22. Banks, WA (2008). Developing drugs that can cross the blood-brain barrier: applications to Alzheimer's disease. BMC Neurosci 9 (suppl. 3): S2.
23. Schäfer, A, Brooke, CB, Whitmore, AC and Johnston, RE (2011). The role of the blood-brain barrier during Venezuelan equine encephalitis virus infection. J Virol 85: 10682-10690.
24. Koffie, RM, Farrar, CT, Saidi, LJ, William, CM, Hyman, BT and Spires-Jones, TL (2011). Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging. Proc Natl Acad Sci USA 108: 18837-18842.
25. Allen, DD and Lockman, PR (2003). The blood-brain barrier choline transporter as a brain drug delivery vector. Life Sci 73: 1609-1615. (Pubitemid 36869002)
26. Foust, KD, Nurre, E, Montgomery, CL, Hernandez, A, Chan, CM and Kaspar, BK (2009). Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes. Nat Biotechnol 27: 59-65.
27. Chen, YH, Chang, M and Davidson, BL (2009). Molecular signatures of disease brain endothelia provide new sites for CNS-directed enzyme therapy. Nat Med 15: 1215-1218.
28. Pasqualini, R and Ruoslahti, E (1996). Organ targeting in vivo using phage display peptide libraries. Nature 380: 364-366. (Pubitemid 26097120)
29. Liu, NQ, Lossinsky, AS, Popik, W, Li, X, Gujuluva, C, Kriederman, B et al. (2002). Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway. J Virol 76: 6689-6700. (Pubitemid 34633535)
30. Tang, Y, Han, T, Everts, M, Zhu, ZB, Gillespie, GY, Curiel, DT et al. (2007). Directing adenovirus across the blood-brain barrier via melanotransferrin (P97) transcytosis pathway in an in vitro model. Gene Ther 14: 523-532. (Pubitemid 46390925)
31. Stojanov, K, Georgieva, JV, Brinkhuis, RP, van Hest, JC, Rutjes, FP, Dierckx, RA et al. (2012). In vivo biodistribution of prion- and GM1-targeted polymersomes following intravenous administration in mice. Mol Pharm 9: 1620-1627.
32. Hanss, B, Leal-Pinto, E, Bruggeman, LA, Copeland, TD and Klotman, PE (1998). Identification and characterization of a cell membrane nucleic acid channel. Proc Natl Acad Sci USA 95: 1921-1926. (Pubitemid 28103495)
33. Reyes-Reyes, EM, Teng, Y and Bates, PJ (2010). A new paradigm for aptamer therapeutic AS1411 action: uptake by macropinocytosis and its stimulation by a nucleolindependentmechanism. Cancer Res 70: 8617-8629.
34. Magalhães, ML, Byrom, M, Yan, A, Kelly, L, Li, N, Furtado, R et al. (2012). A general RNA motif for cellular transfection. Mol Ther 20: 616-624.
35. Dorner, M, Horwitz, JA, Robbins, JB, Barry, WT, Feng, Q, Mu, K et al. (2011). A genetically humanized mouse model for hepatitis C virus infection. Nature 474: 208-211.
36. Li, N, Larson, T, Nguyen, HH, Sokolov, KV and Ellington, AD (2010). Directed evolution of gold nanoparticle delivery to cells. Chem Commun (Camb) 46: 392-394.
37. Mayer, G, Ahmed, MS, Dolf, A, Endl, E, Knolle, PA and Famulok, M (2010). Fluorescenceactivated cell sorting for aptamer SELEX with cell mixtures. Nat Protoc 5: 1993-2004.
38. Shigdar, S, Lin, J, Yu, Y, Pastuovic, M, Wei, M and Duan, W (2011). RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule. Cancer Sci 102: 991-998.
39. Triguero, D, Buciak, J and Pardridge, WM (1990). Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins. J Neurochem 54: 1882-1888.
40. Friden, PM, Walus, LR, Musso, GF, Taylor, MA, Malfroy, B and Starzyk, RM (1991). Antitransferrin receptor antibody and antibody-drug conjugates cross the blood-brain barrier. Proc Natl Acad Sci USA 88: 4771-4775. (Pubitemid 21914624)
41. Tachikawa, M, Toki, H, Tomi, M and Hosoya, K (2008). Gene expression profiles of ATPbinding cassette transporter A and C subfamilies in mouse retinal vascular endothelial cells. Microvasc Res 75: 68-72. (Pubitemid 350266735)
42. De Block, M and Debrouwer, D (1993). RNA-RNA in situ hybridization using digoxigeninlabeled probes: the use of high-molecular-weight polyvinyl alcohol in the alkaline phosphatase indoxyl-nitroblue tetrazolium reaction. Anal Biochem 215: 86-89. (Pubitemid 23339687)