메뉴 건너뛰기




Volumn 12, Issue 5, 2014, Pages 707-717

Genes of human longevity: An endless quest?

Author keywords

APOE; ELOVL2; Epigenetics; IGF 1; Longevity; Microbiota; mtDNA; mTOR

Indexed keywords

APOLIPOPROTEIN E; DNA METHYLTRANSFERASE 1; GROWTH HORMONE; GROWTH HORMONE RECEPTOR; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA; MITOCHONDRIAL DNA; SOMATOMEDIN C RECEPTOR; MTOR PROTEIN, HUMAN; SOMATOMEDIN C; TARGET OF RAPAMYCIN KINASE;

EID: 84924091788     PISSN: 15701611     EISSN: 18756212     Source Type: Journal    
DOI: 10.2174/1570161111666131219110301     Document Type: Article
Times cited : (19)

References (133)
  • 1
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 2012; 489: 57-74.
    • (2012) Nature , vol.489 , pp. 57-74
  • 2
    • 84855979661 scopus 로고    scopus 로고
    • Whole genome sequences of a male and female supercentenarian, ages greater than 114+ years
    • Sebastiani P, Riva A, Montano M, et al. Whole genome sequences of a male and female supercentenarian, ages greater than 114+ years. Front Genet 2011; 2: 90-118.
    • (2011) Front Genet , vol.2 , pp. 90-118
    • Sebastiani, P.1    Riva, A.2    Montano, M.3
  • 3
    • 84878933045 scopus 로고    scopus 로고
    • Genome-wide linkage analysis for human longevity: Genetics of healthy ageing study
    • Beekman M, Blanché H, Perola M, et al. Genome-wide linkage analysis for human longevity: Genetics of healthy ageing study. Aging Cell 2013; 12: 184-93.
    • (2013) Aging Cell , vol.12 , pp. 184-193
    • Beekman, M.1    Blanché, H.2    Perola, M.3
  • 4
    • 77950254226 scopus 로고    scopus 로고
    • Systems biology and longevity: An emerging approach to identify innovative anti-aging targets and strategies
    • Cevenini E, Bellavista E, Tieri P, et al. Systems biology and longevity: an emerging approach to identify innovative anti-aging targets and strategies. Curr Pharm Des 2010; 16: 802-13.
    • (2010) Curr Pharm Des , vol.16 , pp. 802-813
    • Cevenini, E.1    Bellavista, E.2    Tieri, P.3
  • 7
    • 33846111415 scopus 로고    scopus 로고
    • Inflamm-aging and antiinflamm-aging: A systemic perspective on aging and longevity emerged from studies in humans
    • Franceschi C, Capri M, Monti D, et al. Inflamm-aging and antiinflamm-aging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 2007; 128: 92-105.
    • (2007) Mech Ageing Dev , vol.128 , pp. 92-105
    • Franceschi, C.1    Capri, M.2    Monti, D.3
  • 8
    • 84874963173 scopus 로고    scopus 로고
    • Identifying the genomic determinants of aging and longevity in human population studies: Progress and challenges
    • Deelen J, Beekman M, Capri M, et al. Identifying the genomic determinants of aging and longevity in human population studies: Progress and challenges. Bioessays 2013; 35: 386-96.
    • (2013) Bioessays , vol.35 , pp. 386-396
    • Deelen, J.1    Beekman, M.2    Capri, M.3
  • 9
    • 0038637217 scopus 로고    scopus 로고
    • Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: Cues for an evolutionarily conserved mechanism of life span control
    • Bonafè M, Barbieri M, Marchegiani F, et al. Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. J Clin Endocrinol Metab 2003; 88: 3299-304.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3299-3304
    • Bonafè, M.1    Barbieri, M.2    Marchegiani, F.3
  • 10
    • 77749316176 scopus 로고    scopus 로고
    • Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: From yeast to the mammalian brain
    • Parrella E, Longo VD. Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. ScientificWorldJournal 2010; 10: 161-77.
    • (2010) ScientificWorldJournal , vol.10 , pp. 161-177
    • Parrella, E.1    Longo, V.D.2
  • 11
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span-from yeast to humans
    • Fontana L, Partridge L, Longo VD. Extending healthy life span-from yeast to humans. Science 2010; 328: 321-6.
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 12
    • 13944276264 scopus 로고    scopus 로고
    • Life extension in the dwarf mouse
    • Bartke A, Brown-Borg H. Life extension in the dwarf mouse. Curr Top Dev Biol 2004; 63: 189-225.
    • (2004) Curr Top Dev Biol , vol.63 , pp. 189-225
    • Bartke, A.1    Brown-Borg, H.2
  • 13
    • 65549149453 scopus 로고    scopus 로고
    • Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice
    • Ikeno Y, Hubbard GB, Lee S, et al. Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci 2009; 64: 522-9.
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 , pp. 522-529
    • Ikeno, Y.1    Hubbard, G.B.2    Lee, S.3
  • 14
    • 84858000209 scopus 로고    scopus 로고
    • The sirtuin SIRT6 regulates lifespan in male mice
    • Kanfi Y, Naiman S, Amir G, et al. The sirtuin SIRT6 regulates lifespan in male mice. Nature 2012; 483: 218-21.
    • (2012) Nature , vol.483 , pp. 218-221
    • Kanfi, Y.1    Naiman, S.2    Amir, G.3
  • 15
    • 0142052858 scopus 로고    scopus 로고
    • Insulin/IGFIsignaling pathway: An evolutionarily conserved mechanism of longevity from yeast to humans
    • Barbieri M, Bonafe M, Franceschi C, Paolisso G. Insulin/IGFIsignaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans. Am J Physiol Endocrinol Metab 2003; 285: E1064-71.
    • (2003) Am J Physiol Endocrinol Metab , vol.285 , pp. 1064-1071
    • Barbieri, M.1    Bonafe, M.2    Franceschi, C.3    Paolisso, G.4
  • 16
    • 0037372505 scopus 로고    scopus 로고
    • Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons
    • Barbieri M, Ferrucci L, Ragno E, et al. Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons. Am J Physiol Endocrinol Metab 2003; 284: E481-7.
    • (2003) Am J Physiol Endocrinol Metab , vol.284 , pp. 481-487
    • Barbieri, M.1    Ferrucci, L.2    Ragno, E.3
  • 17
    • 42149141146 scopus 로고    scopus 로고
    • Functionally significant insulinlike growth factor I receptor mutations in centenarians
    • Suh Y, Atzmon G, Cho MO, et al. Functionally significant insulinlike growth factor I receptor mutations in centenarians. Proc Natl Acad Sci USA 2008; 105: 3438-42.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3438-3442
    • Suh, Y.1    Atzmon, G.2    Cho, M.O.3
  • 18
    • 67651151249 scopus 로고    scopus 로고
    • Study of Osteoporotic Fractures. Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity
    • Pawlikowska L, Hu D, Huntsman S, et al. Study of Osteoporotic Fractures. Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell 2009; 8(4): 460-72.
    • (2009) Aging Cell , vol.8 , Issue.4 , pp. 460-472
    • Pawlikowska, L.1    Hu, D.2    Huntsman, S.3
  • 19
    • 79956016645 scopus 로고    scopus 로고
    • Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles
    • Tazearslan C, Huang J, Barzilai N, Suh Y. Impaired IGF1R signaling in cells expressing longevity-associated human IGF1R alleles. Aging Cell 2011; 10: 551-4.
    • (2011) Aging Cell , vol.10 , pp. 551-554
    • Tazearslan, C.1    Huang, J.2    Barzilai, N.3    Suh, Y.4
  • 20
    • 84872589478 scopus 로고    scopus 로고
    • Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians' offspring
    • Vitale G, Brugts MP, Ogliari G, et al. Low circulating IGF-I bioactivity is associated with human longevity: Findings in centenarians' offspring. Aging (Albany NY) 2012; 4: 580-9.
    • (2012) Aging (Albany NY) , vol.4 , pp. 580-589
    • Vitale, G.1    Brugts, M.P.2    Ogliari, G.3
  • 21
    • 74949110981 scopus 로고    scopus 로고
    • Leiden Longevity Study (LLS) Group. Human insulin/IGF and familial longevity at middle age
    • Rozing MP, Westendorp RG, Frölich M, et al. Leiden Longevity Study (LLS) Group. Human insulin/IGF and familial longevity at middle age. Aging (Albany NY) 2009; 1: 714-722.
    • (2009) Aging (Albany NY) , vol.1 , pp. 714-722
    • Rozing, M.P.1    Westendorp, R.G.2    Frölich, M.3
  • 22
    • 84859853540 scopus 로고    scopus 로고
    • Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: Cross sectional and longitudinal studies
    • Soerensen M, Dato S, Tan Q, et al. Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies. Exp Gerontol 2012; 47: 379-87.
    • (2012) Exp Gerontol , vol.47 , pp. 379-387
    • Soerensen, M.1    Dato, S.2    Tan, Q.3
  • 23
    • 0027435266 scopus 로고
    • Complex alteration of thyroid function in healthy centenarians
    • Mariotti S, Barbesino G, Caturegli P, et al. Complex alteration of thyroid function in healthy centenarians. J Clin Endocrinol Metab 1993; 77: 1130-4.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 1130-1134
    • Mariotti, S.1    Barbesino, G.2    Caturegli, P.3
  • 24
    • 77958530034 scopus 로고    scopus 로고
    • A cross-section analysis of FT3 age-related changes in a group of old and oldestold subjects, including centenarians' relatives, shows that a down regulated thyroid function has a familial component and is related to longevity
    • Corsonello A, Montesanto A, Berardelli M, et al. A cross-section analysis of FT3 age-related changes in a group of old and oldestold subjects, including centenarians' relatives, shows that a down regulated thyroid function has a familial component and is related to longevity. Age Ageing 2010; 39: 723-7.
    • (2010) Age Ageing , vol.39 , pp. 723-727
    • Corsonello, A.1    Montesanto, A.2    Berardelli, M.3
  • 25
    • 78049504481 scopus 로고    scopus 로고
    • Familial longevity is associated with decreased thyroid function
    • Rozing MP, Houwing-Duistermaat JJ, et al. Familial longevity is associated with decreased thyroid function. J Clin Endocrinol Metab 2010; 95: 4979-84.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 4979-4984
    • Rozing, M.P.1    Houwing-Duistermaat, J.J.2
  • 26
    • 77950478167 scopus 로고    scopus 로고
    • Leiden Longevity Study (LLS) Group. Low serum free triiodothyronine levels mark familial longevity: The Leiden Longevity Study
    • Rozing MP, Westendorp RG, de Craen AJ, et al. Leiden Longevity Study (LLS) Group. Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study. J Gerontol A Biol Sci Med Sci 2010; 65: 365-8.
    • (2010) J Gerontol A Biol Sci Med Sci , vol.65 , pp. 365-368
    • Rozing, M.P.1    Westendorp, R.G.2    de Craen, A.J.3
  • 27
    • 57149112134 scopus 로고    scopus 로고
    • Influence of f-MLP, ACTH(1-24) and CRH on in vitro chemotaxis of monocytes from centenarians
    • Genedani S, Filaferro M, Carone C, et al. Influence of f-MLP, ACTH(1-24) and CRH on in vitro chemotaxis of monocytes from centenarians. Neuroimmunomodulation 2008; 15: 285-9.
    • (2008) Neuroimmunomodulation , vol.15 , pp. 285-289
    • Genedani, S.1    Filaferro, M.2    Carone, C.3
  • 28
    • 84874755914 scopus 로고    scopus 로고
    • Assessment of adiponectin and its isoforms in Polish centenarians
    • Bik W, Baranowska-Bik A, Wolinska-Witort E, et al. Assessment of adiponectin and its isoforms in Polish centenarians. Exp Gerontol 2013; 48(4): 401-7.
    • (2013) Exp Gerontol , vol.48 , Issue.4 , pp. 401-407
    • Bik, W.1    Baranowska-Bik, A.2    Wolinska-Witort, E.3
  • 29
    • 47049090142 scopus 로고    scopus 로고
    • Adiponectin levels and genotype: A potential regulator of life span in humans
    • Atzmon G, Pollin TI, Crandall J, et al. Adiponectin levels and genotype: a potential regulator of life span in humans. J Gerontol A Biol Sci Med Sci 2008; 63: 447-53.
    • (2008) J Gerontol A Biol Sci Med Sci , vol.63 , pp. 447-453
    • Atzmon, G.1    Pollin, T.I.2    Crandall, J.3
  • 30
    • 84881252668 scopus 로고    scopus 로고
    • Circulating levels of adipokines and IGF-1 are associated with skeletal muscle strength of young and old healthy subjects
    • Bucci L, Yani SL, Fabbri C, et al. Circulating levels of adipokines and IGF-1 are associated with skeletal muscle strength of young and old healthy subjects. Biogerontology 2013, 14: 261-72.
    • (2013) Biogerontology , vol.14 , pp. 261-272
    • Bucci, L.1    Yani, S.L.2    Fabbri, C.3
  • 31
    • 18144408371 scopus 로고    scopus 로고
    • Adipose tissue, adipokines, and inflammation
    • Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 2005; 115: 911-9.
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 911-919
    • Fantuzzi, G.1
  • 32
    • 34250884797 scopus 로고    scopus 로고
    • Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice
    • Wang Z, Masternak MM, Al-Regaiey KA, Bartke A. Adipocytokines and the regulation of lipid metabolism in growth hormone transgenic and calorie-restricted mice. Endocrinology 2007; 148: 2845-53.
    • (2007) Endocrinology , vol.148 , pp. 2845-2853
    • Wang, Z.1    Masternak, M.M.2    Al-Regaiey, K.A.3    Bartke, A.4
  • 33
    • 84855832253 scopus 로고    scopus 로고
    • Metabolic effects of intra-abdominal fat in GHRKO mice
    • Masternak MM, Bartke A, Wang F, et al. Metabolic effects of intra-abdominal fat in GHRKO mice. Aging Cell 2012; 11: 73-81.
    • (2012) Aging Cell , vol.11 , pp. 73-81
    • Masternak, M.M.1    Bartke, A.2    Wang, F.3
  • 34
    • 80053235435 scopus 로고    scopus 로고
    • Caloric restriction: Powerful protection for the aging heart and vasculature
    • Weiss EP, Fontana L. Caloric restriction: powerful protection for the aging heart and vasculature. Am J Physiol Heart Circ Physiol 2011; 301: H1205-19.
    • (2011) Am J Physiol Heart Circ Physiol , vol.301 , pp. 1205-1219
    • Weiss, E.P.1    Fontana, L.2
  • 35
    • 46449095385 scopus 로고    scopus 로고
    • Caloric restriction but not exercise-induced reductions in fat mass decrease plasma triiodothyronine concentrations: A randomized controlled trial
    • Weiss EP, Villareal DT, Racette SB, et al. Caloric restriction but not exercise-induced reductions in fat mass decrease plasma triiodothyronine concentrations: a randomized controlled trial. Rejuvenation Res 2008; 11: 605-9.
    • (2008) Rejuvenation Res , vol.11 , pp. 605-609
    • Weiss, E.P.1    Villareal, D.T.2    Racette, S.B.3
  • 36
    • 77949424755 scopus 로고    scopus 로고
    • Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production
    • Fontana L, Klein S, Holloszy JO. Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production. Age (Dordr) 2010; 32: 97-108.
    • (2010) Age (Dordr) , vol.32 , pp. 97-108
    • Fontana, L.1    Klein, S.2    Holloszy, J.O.3
  • 37
    • 84864017471 scopus 로고    scopus 로고
    • Caloric restriction may reverse age-related autonomic decline in humans
    • Stein PK, Soare A, Meyer TE, et al. Caloric restriction may reverse age-related autonomic decline in humans. Aging Cell 2012; 11: 644-50.
    • (2012) Aging Cell , vol.11 , pp. 644-650
    • Stein, P.K.1    Soare, A.2    Meyer, T.E.3
  • 38
    • 84880509894 scopus 로고    scopus 로고
    • Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile
    • Mercken EM, Crosby SD, Lamming DW, et al. Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell 2013; 12: 645-51.
    • (2013) Aging Cell , vol.12 , pp. 645-651
    • Mercken, E.M.1    Crosby, S.D.2    Lamming, D.W.3
  • 39
    • 79951938474 scopus 로고    scopus 로고
    • Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans
    • 70ra13
    • Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, et al. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med 2011; 3: 70ra13.
    • (2011) Sci Transl Med , vol.3
    • Guevara-Aguirre, J.1    Balasubramanian, P.2    Guevara-Aguirre, M.3
  • 40
    • 84908596338 scopus 로고    scopus 로고
    • Association between genetic variations in the Insulin/Insulin-like growth factor (IGF-1) signaling pathway and longevity: A systematic review and metaanalysis
    • Di Bona D, Accardi G, Virruso C, et al. Association between genetic variations in the Insulin/Insulin-like growth factor (IGF-1) signaling pathway and longevity: a systematic review and metaanalysis. Curr Vasc Pharmacol 2014; 12(5): 674-81.
    • (2014) Curr Vasc Pharmacol , vol.12 , Issue.5 , pp. 674-681
    • Di Bona, D.1    Accardi, G.2    Virruso, C.3
  • 41
    • 84881222909 scopus 로고    scopus 로고
    • Age-dependent alteration in muscle regeneration: The critical role of tissue niche
    • Barberi L, Scicchitano BM, De Rossi M, et al. Age-dependent alteration in muscle regeneration: the critical role of tissue niche. Biogerontology 2013; 14: 273-92.
    • (2013) Biogerontology , vol.14 , pp. 273-292
    • Barberi, L.1    Scicchitano, B.M.2    De Rossi, M.3
  • 42
    • 79953231709 scopus 로고    scopus 로고
    • A longer and healthier life with TOR downregulation: Genetics and drugs
    • Bjedov I, Partridge L. A longer and healthier life with TOR downregulation: genetics and drugs. Biochem Soc Trans 2011; 39: 460-465.
    • (2011) Biochem Soc Trans , vol.39 , pp. 460-465
    • Bjedov, I.1    Partridge, L.2
  • 43
    • 77956511229 scopus 로고    scopus 로고
    • Complex patterns of gene expression in human T cells during in vivo aging
    • Remondini D, Salvioli S, Francesconi M, et al. Complex patterns of gene expression in human T cells during in vivo aging. Mol Biosyst. 2010; 6(10): 1983-92.
    • (2010) Mol Biosyst , vol.6 , Issue.10 , pp. 1983-1992
    • Remondini, D.1    Salvioli, S.2    Francesconi, M.3
  • 44
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: From growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12: 21-35.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 45
    • 84555187749 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: A signaling kinase for every aspect of cellular life
    • Weichhart T. Mammalian target of rapamycin: a signaling kinase for every aspect of cellular life. Methods Mol Biol 2012; 821: 1-14.
    • (2012) Methods Mol Biol , vol.821 , pp. 1-14
    • Weichhart, T.1
  • 46
    • 84859117806 scopus 로고    scopus 로고
    • Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
    • Lamming DW, Ye L, Katajisto P, et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 2012; 335: 1638-43.
    • (2012) Science , vol.335 , pp. 1638-1643
    • Lamming, D.W.1    Ye, L.2    Katajisto, P.3
  • 47
    • 84872620350 scopus 로고    scopus 로고
    • Gene expression analysis of mTOR pathway: Association with human longevity
    • Passtoors WM, Beekman M, Deelen J, et al. Gene expression analysis of mTOR pathway: association with human longevity. Aging Cell 2012; 12: 24-31.
    • (2012) Aging Cell , vol.12 , pp. 24-31
    • Passtoors, W.M.1    Beekman, M.2    Deelen, J.3
  • 48
    • 84865401134 scopus 로고    scopus 로고
    • Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations
    • Harries LW, Fellows AD, Pilling LC, et al. Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations. Mech Ageing Dev 2012; 133: 556-62.
    • (2012) Mech Ageing Dev , vol.133 , pp. 556-562
    • Harries, L.W.1    Fellows, A.D.2    Pilling, L.C.3
  • 49
    • 35348972430 scopus 로고    scopus 로고
    • Genetic links between diet and lifespan: Shared mechanisms from yeast to humans
    • Bishop NA, Guarente L. Genetic links between diet and lifespan: shared mechanisms from yeast to humans. Nat Rev Genet 2007; 8: 835-44.
    • (2007) Nat Rev Genet , vol.8 , pp. 835-844
    • Bishop, N.A.1    Guarente, L.2
  • 51
    • 3242724126 scopus 로고    scopus 로고
    • Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity
    • Barbieri M, Bonafè M, Rizzo MR, et al. Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)gamma-2 with longevity. Exp Gerontol 2004; 39: 1095-100.
    • (2004) Exp Gerontol , vol.39 , pp. 1095-1100
    • Barbieri, M.1    Bonafè, M.2    Rizzo, M.R.3
  • 52
    • 84924177284 scopus 로고    scopus 로고
    • Ageing mechanisms and associated lipid changes
    • Kolovou G, Katsiki N, Pavlidis A, et al. Ageing mechanisms and associated lipid changes. Curr Vasc Pharmacol 2014; 12(5): 682-9.
    • (2014) Curr Vasc Pharmacol , vol.12 , Issue.5 , pp. 682-689
    • Kolovou, G.1    Katsiki, N.2    Pavlidis, A.3
  • 53
    • 84924137819 scopus 로고    scopus 로고
    • Phenotypes and Genotypes of High Density Lipoprotein Cholesterol in Exceptional Longevity
    • Milman S, Atzmon G, Crandal J, Barzilai N. Phenotypes and Genotypes of High Density Lipoprotein Cholesterol in Exceptional Longevity. Curr Vasc Pharmacol 2014; 12(5): 690-7.
    • (2014) Curr Vasc Pharmacol , vol.12 , Issue.5 , pp. 690-697
    • Milman, S.1    Atzmon, G.2    Crandal, J.3    Barzilai, N.4
  • 54
    • 12144290008 scopus 로고    scopus 로고
    • The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects
    • Garasto S, Rose G, Derango F, et al. The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects. Ann Hum Genet 2003; 67(Pt 1): 54-62.
    • (2003) Ann Hum Genet , vol.67 , pp. 54-62
    • Garasto, S.1    Rose, G.2    Derango, F.3
  • 55
    • 0031684963 scopus 로고    scopus 로고
    • Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts
    • De Benedictis G, Carotenuto L, Carrieri G, et al. Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts. Ann Hum Genet 1998; 62(Pt 2): 115-22.
    • (1998) Ann Hum Genet , vol.62 , pp. 115-122
    • De Benedictis, G.1    Carotenuto, L.2    Carrieri, G.3
  • 56
    • 17744397107 scopus 로고    scopus 로고
    • Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease
    • Carrieri G, Bonafè M, De Luca M, et al. Mitochondrial DNA haplogroups and APOE4 allele are non-independent variables in sporadic Alzheimer's disease. Hum Genet 2001; 108: 194-8.
    • (2001) Hum Genet , vol.108 , pp. 194-198
    • Carrieri, G.1    Bonafè, M.2    De Luca, M.3
  • 57
    • 79955636270 scopus 로고    scopus 로고
    • An APOE haplotype associated with decreased e4 expression increases the risk of late onset alzheimer's disease
    • Lescai F, Chiamenti AM, Codemo A, et al. An APOE haplotype associated with decreased e4 expression increases the risk of late onset alzheimer's disease. J Alzheimers Dis 2011; 24(2): 235-45.
    • (2011) J Alzheimers Dis , vol.24 , Issue.2 , pp. 235-245
    • Lescai, F.1    Chiamenti, A.M.2    Codemo, A.3
  • 58
    • 84872298321 scopus 로고    scopus 로고
    • Apolipoprotein E and familial longevity
    • Schupf N, Barral S, Perls T, et al. Apolipoprotein E and familial longevity. Neurobiol Aging 2013; 34: 1287-91.
    • (2013) Neurobiol Aging , vol.34 , pp. 1287-1291
    • Schupf, N.1    Barral, S.2    Perls, T.3
  • 59
    • 84855955362 scopus 로고    scopus 로고
    • Genetic signatures of exceptional longevity in humans
    • Sebastiani P, Solovieff N, Dewan AT, et al. Genetic signatures of exceptional longevity in humans. PLoS One 2012; 7: e29848.
    • (2012) PLoS One , vol.7
    • Sebastiani, P.1    Solovieff, N.2    Dewan, A.T.3
  • 60
    • 84880569861 scopus 로고    scopus 로고
    • Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity
    • Soerensen M, Dato S, Tan Q, et al. Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity. Age (Dordr) 2013; 35: 487-500.
    • (2013) Age (Dordr) , vol.35 , pp. 487-500
    • Soerensen, M.1    Dato, S.2    Tan, Q.3
  • 61
    • 0142088521 scopus 로고    scopus 로고
    • Unique lipoprotein phenotype and genotype associated with exceptional longevity
    • Barzilai N, Atzmon G, Schechter C, et al. Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA 2003; 290: 2030-40.
    • (2003) JAMA , vol.290 , pp. 2030-2040
    • Barzilai, N.1    Atzmon, G.2    Schechter, C.3
  • 62
    • 18844400549 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians
    • Cellini E, Nacmias B, Olivieri F, et al. Cholesteryl ester transfer protein (CETP) I405V polymorphism and longevity in Italian centenarians. Mech Ageing Dev 2005; 126: 826-8.
    • (2005) Mech Ageing Dev , vol.126 , pp. 826-828
    • Cellini, E.1    Nacmias, B.2    Olivieri, F.3
  • 63
    • 48949119164 scopus 로고    scopus 로고
    • The impact of mitochondrial DNA on human lifespan: A view from studies on centenarians
    • Salvioli S, Capri M, Santoro A, et al. The impact of mitochondrial DNA on human lifespan: a view from studies on centenarians. Biotechnol J 2008; 3: 740-9.
    • (2008) Biotechnol J , vol.3 , pp. 740-749
    • Salvioli, S.1    Capri, M.2    Santoro, A.3
  • 64
  • 65
    • 0347600946 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations in human colonic crypt stem cells
    • Taylor RW, Barron MJ, Borthwick GM, et al. Mitochondrial DNA mutations in human colonic crypt stem cells. J Clin Invest 2003; 112: 1351-60.
    • (2003) J Clin Invest , vol.112 , pp. 1351-1360
    • Taylor, R.W.1    Barron, M.J.2    Borthwick, G.M.3
  • 66
    • 0037117576 scopus 로고    scopus 로고
    • Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues
    • Nekhaeva E, Bodyak ND, Kraytsberg Y, et al. Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proc Natl Acad Sci USA 2002; 99: 5521-6.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 5521-5526
    • Nekhaeva, E.1    Bodyak, N.D.2    Kraytsberg, Y.3
  • 67
    • 33748979744 scopus 로고    scopus 로고
    • Mitochondrial DNA involvement in human longevity
    • Santoro A, Salvioli S, Raule N, et al. Mitochondrial DNA involvement in human longevity. Biochim Biophys Acta 2006; 1757: 1388-99.
    • (2006) Biochim Biophys Acta , vol.1757 , pp. 1388-1399
    • Santoro, A.1    Salvioli, S.2    Raule, N.3
  • 68
    • 84871565767 scopus 로고    scopus 로고
    • Universal heteroplasmy of human mitochondrial DNA
    • Payne BA, Wilson IJ, Yu-Wai-Man P, et al. Universal heteroplasmy of human mitochondrial DNA. Hum Mol Genet 2013; 22: 384-90.
    • (2013) Hum Mol Genet , vol.22 , pp. 384-390
    • Payne, B.A.1    Wilson, I.J.2    Yu-Wai-Man, P.3
  • 69
    • 35248861556 scopus 로고    scopus 로고
    • The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring
    • Rose G, Passarino G, Scornaienchi V, et al. The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring. BMC Genomics 2007; 8: 293-303.
    • (2007) BMC Genomics , vol.8 , pp. 293-303
    • Rose, G.1    Passarino, G.2    Scornaienchi, V.3
  • 70
    • 0037417898 scopus 로고    scopus 로고
    • Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes. Proc
    • Zhang J, Asin-Cayuela J, Fish J, et al. Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes. Proc. Natl Acad Sci USA 2003; 100: 1116-21.
    • (2003) Natl Acad Sci USA , vol.100 , pp. 1116-1121
    • Zhang, J.1    Asin-Cayuela, J.2    Fish, J.3
  • 71
    • 0037209210 scopus 로고    scopus 로고
    • Mitochondrial DNA polymorphisms associated with longevity in a Finnish population
    • Niemi AK, Hervonen A, Hurme M, et al. Mitochondrial DNA polymorphisms associated with longevity in a Finnish population. Hum Genet 2003; 112: 29-33.
    • (2003) Hum Genet , vol.112 , pp. 29-33
    • Niemi, A.K.1    Hervonen, A.2    Hurme, M.3
  • 72
    • 13544272017 scopus 로고    scopus 로고
    • A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects
    • Niemi AK, Moilanen JS, Tanaka M, et al. A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects. Eur J Hum Genet 2005; 13: 166-170.
    • (2005) Eur J Hum Genet , vol.13 , pp. 166-170
    • Niemi, A.K.1    Moilanen, J.S.2    Tanaka, M.3
  • 73
    • 78149455668 scopus 로고    scopus 로고
    • Genetics of healthy ageing project consortium. Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: A GEHA study
    • Rose G, Romeo G, Dato S, et al. Genetics of healthy ageing project consortium. Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA study. PLoS One. 2010; 5: e13395.
    • (2010) PLoS One , vol.5
    • Rose, G.1    Romeo, G.2    Dato, S.3
  • 74
    • 84901209263 scopus 로고    scopus 로고
    • The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, does matter for human longevity and is population specific
    • Raule N, Sevini F, Lib S, et al. The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, does matter for human longevity and is population specific. Ageing Cell 2014; 13(3): 401-7.
    • (2014) Ageing Cell , vol.13 , Issue.3 , pp. 401-407
    • Raule, N.1    Sevini, F.2    Lib, S.3
  • 75
    • 0026340064 scopus 로고
    • The structure of human mitochondrial DNA variation
    • Merriwether DA, Clark AG, Ballinger SW, et al. The structure of human mitochondrial DNA variation, J Mol Evol 1991; 33: 543-55.
    • (1991) J Mol Evol , vol.33 , pp. 543-555
    • Merriwether, D.A.1    Clark, A.G.2    Ballinger, S.W.3
  • 77
    • 0347356538 scopus 로고    scopus 로고
    • Effects of purifying and adaptive selection on regional variation in human mtDNA
    • Ruiz-Pesini E, Mishmar D, Brandon M, et al. Effects of purifying and adaptive selection on regional variation in human mtDNA. Science 2004; 303: 223-6.
    • (2004) Science , vol.303 , pp. 223-226
    • Ruiz-Pesini, E.1    Mishmar, D.2    Brandon, M.3
  • 78
    • 33244457956 scopus 로고    scopus 로고
    • The role of selection in the evolution of human mitochondrial genomes
    • Kivisild T, Shen P, Wall DP, et al. The role of selection in the evolution of human mitochondrial genomes. Genetics 2006: 172: 373-87.
    • (2006) Genetics , vol.172 , pp. 373-387
    • Kivisild, T.1    Shen, P.2    Wall, D.P.3
  • 79
    • 0032851615 scopus 로고    scopus 로고
    • Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans
    • De Benedictis G, Rose G, Carrieri G, et al. Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. FASEB J 1999; 13: 1532-36.
    • (1999) FASEB J , vol.13 , pp. 1532-1536
    • De Benedictis, G.1    Rose, G.2    Carrieri, G.3
  • 80
    • 48749085727 scopus 로고    scopus 로고
    • Mitochondrial DNA haplogroup D4a is a marker for extreme longevity in Japan
    • Bilal E, Rabadan R, Alexe G, et al. Mitochondrial DNA haplogroup D4a is a marker for extreme longevity in Japan. PLoS One 2008; 11: e2421.
    • (2008) PLoS One , vol.11
    • Bilal, E.1    Rabadan, R.2    Alexe, G.3
  • 81
    • 84868130688 scopus 로고    scopus 로고
    • Decreased reactive oxygen species production in cells with mitochondrial haplogroups associated with longevity
    • Chen A, Raule N, Chomyn A, Attardi G. Decreased reactive oxygen species production in cells with mitochondrial haplogroups associated with longevity. PLoS One 2012; 7: e46473.
    • (2012) PLoS One , vol.7
    • Chen, A.1    Raule, N.2    Chomyn, A.3    Attardi, G.4
  • 82
    • 84862322923 scopus 로고    scopus 로고
    • Are mitochondrial haplogroups associated with extreme longevity? A study on a Spanish cohort
    • Pinós T, Nogales-Gadea G, Ruiz JR, et al. Are mitochondrial haplogroups associated with extreme longevity? A study on a Spanish cohort. Age (Dordr) 2012; 34: 227-33.
    • (2012) Age (Dordr) , vol.34 , pp. 227-233
    • Pinós, T.1    Nogales-Gadea, G.2    Ruiz, J.R.3
  • 83
    • 84865123584 scopus 로고    scopus 로고
    • Mitochondrial DNA polymorphisms are associated with the longevity in the Guangxi Bama population of China
    • Yang X, Wang X, Yao H, et al. Mitochondrial DNA polymorphisms are associated with the longevity in the Guangxi Bama population of China. Mol Biol Rep 2012; 39: 9123-31.
    • (2012) Mol Biol Rep , vol.39 , pp. 9123-9131
    • Yang, X.1    Wang, X.2    Yao, H.3
  • 84
    • 80855130558 scopus 로고    scopus 로고
    • Association of mtDNA haplogroup F with healthy longevity in the female Chuang population, China
    • Feng J, Zhang J, Liu M, et al. Association of mtDNA haplogroup F with healthy longevity in the female Chuang population, China. Exp Gerontol 2011; 46(12): 987-93.
    • (2011) Exp Gerontol , vol.46 , Issue.12 , pp. 987-993
    • Feng, J.1    Zhang, J.2    Liu, M.3
  • 85
    • 33847191391 scopus 로고    scopus 로고
    • Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians
    • Fuku N, Park KS, Yamada Y, et al. Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians. Am J Hum Genet 2007; 80: 407-415.
    • (2007) Am J Hum Genet , vol.80 , pp. 407-415
    • Fuku, N.1    Park, K.S.2    Yamada, Y.3
  • 86
    • 79958285686 scopus 로고    scopus 로고
    • Mitochondrial DNA backgrounds might modulate diabetes complications rather than T2DM as a whole
    • Achilli A, Olivieri A, Pala M, et al. Mitochondrial DNA backgrounds might modulate diabetes complications rather than T2DM as a whole. PLoS One 2011; 6: e21029.
    • (2011) PLoS One , vol.6
    • Achilli, A.1    Olivieri, A.2    Pala, M.3
  • 87
    • 55349119132 scopus 로고    scopus 로고
    • Mitochondrial DNA haplogroups and subhaplogroups are associated with Parkinson's disease risk in a Polish PD cohort
    • Gaweda-Walerych K, Maruszak A, Safranow K, et al. Mitochondrial DNA haplogroups and subhaplogroups are associated with Parkinson's disease risk in a Polish PD cohort. J Neural Transm 2008; 115: 1521-26.
    • (2008) J Neural Transm , vol.115 , pp. 1521-1526
    • Gaweda-Walerych, K.1    Maruszak, A.2    Safranow, K.3
  • 88
    • 77957822416 scopus 로고    scopus 로고
    • Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset alzheimer's disease
    • Santoro A, Balbi V, Balducci E, et al. Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset alzheimer's disease. PLoS One 2010; 5: e12037.
    • (2010) PLoS One , vol.5
    • Santoro, A.1    Balbi, V.2    Balducci, E.3
  • 89
    • 84866443759 scopus 로고    scopus 로고
    • Mitochondrial Genomic Analysis of Late Onset alzheimer's Disease Reveals Protective Haplogroups H6A1A/H6A1B: The Cache County Study on Memory in Aging
    • Ridge PG, Maxwell TJ, Corcoran CD, et al. Mitochondrial Genomic Analysis of Late Onset alzheimer's Disease Reveals Protective Haplogroups H6A1A/H6A1B: The Cache County Study on Memory in Aging. PLoS One 2012; 7(9): e45134.
    • (2012) PLoS One , vol.7 , Issue.9
    • Ridge, P.G.1    Maxwell, T.J.2    Corcoran, C.D.3
  • 90
    • 13044306003 scopus 로고    scopus 로고
    • Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2)
    • De Benedictis G, Carotenuto L, Carrieri G, et al. Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2). Eur J Hum Genet 1998; 6: 534-541.
    • (1998) Eur J Hum Genet , vol.6 , pp. 534-541
    • De Benedictis, G.1    Carotenuto, L.2    Carrieri, G.3
  • 91
    • 0037029127 scopus 로고    scopus 로고
    • An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: Implication for an evolutionarily-conserved pathway involved in longevity
    • Bonafé M, Barbi C, Olivieri F, et al. An allele of HRAS1 3'variable number of tandem repeats is a frailty allele: implication for an evolutionarily-conserved pathway involved in longevity. Gene 2002; 286: 121-6.
    • (2002) Gene , vol.286 , pp. 121-126
    • Bonafé, M.1    Barbi, C.2    Olivieri, F.3
  • 92
    • 3242707016 scopus 로고    scopus 로고
    • Analysis of European mitochondrial haplogroups with Alzheimer disease risk
    • van Der Walt JM, Dementieva G, Martin ER, et al. Analysis of European mitochondrial haplogroups with Alzheimer disease risk. Neuroscience Lett 2004; 365: 28-32.
    • (2004) Neuroscience Lett , vol.365 , pp. 28-32
    • van Der Walt, J.M.1    Dementieva, G.2    Martin, E.R.3
  • 93
    • 0041854274 scopus 로고    scopus 로고
    • Mitochondrial DNA modifies cognition in interaction with the nuclear genome and age in mice
    • Roubertoux PL, Sluyter F, Carlier M, et al. Mitochondrial DNA modifies cognition in interaction with the nuclear genome and age in mice. Nat Genet 2003; 35: 65-9.
    • (2003) Nat Genet , vol.35 , pp. 65-69
    • Roubertoux, P.L.1    Sluyter, F.2    Carlier, M.3
  • 94
    • 84867522393 scopus 로고    scopus 로고
    • Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition
    • Sharpley MS, Marciniak C, Eckel-Mahan K, et al. Heteroplasmy of Mouse mtDNA Is Genetically Unstable and Results in Altered Behavior and Cognition. Cell 2012; 151: 333-43.
    • (2012) Cell , vol.151 , pp. 333-343
    • Sharpley, M.S.1    Marciniak, C.2    Eckel-Mahan, K.3
  • 95
    • 33644771161 scopus 로고    scopus 로고
    • Nuclear-mitochondrial epistasis and Drosophila aging: Introgression of Drosophila simulans mtDNA modifies longevity in D. melanogaster nuclear backgrounds
    • Rand DM, Fry A, Sheldahl L. Nuclear-mitochondrial epistasis and Drosophila aging: introgression of Drosophila simulans mtDNA modifies longevity in D. melanogaster nuclear backgrounds. Genetics 2006; 172: 329-41.
    • (2006) Genetics , vol.172 , pp. 329-341
    • Rand, D.M.1    Fry, A.2    Sheldahl, L.3
  • 96
    • 79952445071 scopus 로고    scopus 로고
    • Mitochondrial-nuclear epistasis: Implications for human aging and longevity
    • Tranah GJ. Mitochondrial-nuclear epistasis: implications for human aging and longevity. Ageing Res Rev 2011; 10: 238-52.
    • (2011) Ageing Res Rev , vol.10 , pp. 238-252
    • Tranah, G.J.1
  • 97
    • 33746158952 scopus 로고    scopus 로고
    • Gene expression of cytokines and cytokine receptors is modulated by the common variability of the mitochondrial DNA in cybrid cell lines
    • Bellizzi D, Cavalcante P, Taverna D, et al. Gene expression of cytokines and cytokine receptors is modulated by the common variability of the mitochondrial DNA in cybrid cell lines. Genes Cells 2006; 11: 883-91.
    • (2006) Genes Cells , vol.11 , pp. 883-891
    • Bellizzi, D.1    Cavalcante, P.2    Taverna, D.3
  • 98
    • 84858297200 scopus 로고    scopus 로고
    • SIRT3 gene expression: A link between inherited mitochondrial DNA variants and oxidative stress
    • D'Aquila P, Rose G, Panno ML, et al. SIRT3 gene expression: a link between inherited mitochondrial DNA variants and oxidative stress. Gene 2012; 497: 323-9.
    • (2012) Gene , vol.497 , pp. 323-329
    • D'Aquila, P.1    Rose, G.2    Panno, M.L.3
  • 99
    • 84857353838 scopus 로고    scopus 로고
    • Global DNA methylation levels are modulated by mitochondrial DNA variants
    • Bellizzi D, D'Aquila P, Giordano M, et al. Global DNA methylation levels are modulated by mitochondrial DNA variants. Epigenomics 2012; 4(1): 17-27.
    • (2012) Epigenomics , vol.4 , Issue.1 , pp. 17-27
    • Bellizzi, D.1    D'Aquila, P.2    Giordano, M.3
  • 100
    • 34547890019 scopus 로고    scopus 로고
    • Functions of site-specific histone acetylation and deacetylation
    • Shahbazian MD, Grunstein M. Functions of site-specific histone acetylation and deacetylation. Annu Rev Biochem 2007; 76: 75-100.
    • (2007) Annu Rev Biochem , vol.76 , pp. 75-100
    • Shahbazian, M.D.1    Grunstein, M.2
  • 101
    • 34848815014 scopus 로고    scopus 로고
    • H3K27 demethylases, at long last
    • Swigut T, Wysocka J. H3K27 demethylases, at long last. Cell 2007; 131: 29-32.
    • (2007) Cell , vol.131 , pp. 29-32
    • Swigut, T.1    Wysocka, J.2
  • 102
    • 84869187936 scopus 로고    scopus 로고
    • Methylation of ELOVL2 gene as a new epigenetic marker of age
    • Garagnani P, Bacalini MG, Pirazzini C, et al. Methylation of ELOVL2 gene as a new epigenetic marker of age. Aging Cell 2012; 11: 1132-4.
    • (2012) Aging Cell , vol.11 , pp. 1132-1134
    • Garagnani, P.1    Bacalini, M.G.2    Pirazzini, C.3
  • 103
    • 84862979818 scopus 로고    scopus 로고
    • Distinct DNA methylomes of newborns and centenarians
    • Heyn H, Li N, Ferreira HJ, et al. Distinct DNA methylomes of newborns and centenarians. Proc Natl Acad Sci USA 2012; 109(26): 10522-7.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.26 , pp. 10522-10527
    • Heyn, H.1    Li, N.2    Ferreira, H.J.3
  • 104
    • 84890166425 scopus 로고    scopus 로고
    • Role of epigenetics in human aging and longevity: Genome-wide DNA methylation profile in centenarians and centenarians' offspring
    • Gentilini D, Mari D, Castaldi D, et al. Role of epigenetics in human aging and longevity: genome-wide DNA methylation profile in centenarians and centenarians' offspring. Age (Dordr) 2013; 35: 1961-73.
    • (2013) Age (Dordr) , vol.35 , pp. 1961-1973
    • Gentilini, D.1    Mari, D.2    Castaldi, D.3
  • 105
    • 84874704289 scopus 로고    scopus 로고
    • Does the longevity of one or both parents influence the health status of their offspring?
    • Gueresi P, Miglio R, Monti D, et al. Does the longevity of one or both parents influence the health status of their offspring? Exp Gerontol 2013; 48(4): 395-400.
    • (2013) Exp Gerontol , vol.48 , Issue.4 , pp. 395-400
    • Gueresi, P.1    Miglio, R.2    Monti, D.3
  • 106
    • 84922652623 scopus 로고    scopus 로고
    • Centenarian Offspring: A model for Understanding Longevity
    • Balistreri CR, Accardi G, Buffa S, et al. Centenarian Offspring: a model for Understanding Longevity. Current Vasc Pharmacol 2014; 12(5): 718-25.
    • (2014) Current Vasc Pharmacol , vol.12 , Issue.5 , pp. 718-725
    • Balistreri, C.R.1    Accardi, G.2    Buffa, S.3
  • 107
    • 84858336995 scopus 로고    scopus 로고
    • Age-dependent skewing of X chromosome inactivation appears delayed in centenarians' offspring. Is there a role for allelic imbalance in healthy aging and longevity?
    • Gentilini D, Castaldi D, Mari D, et al. Age-dependent skewing of X chromosome inactivation appears delayed in centenarians' offspring. Is there a role for allelic imbalance in healthy aging and longevity? Aging Cell 2012; 11: 277-83.
    • (2012) Aging Cell , vol.11 , pp. 277-283
    • Gentilini, D.1    Castaldi, D.2    Mari, D.3
  • 108
    • 0034065926 scopus 로고    scopus 로고
    • Hemopoiesis in healthy old people and centenarians: Well-maintained responsiveness of CD34+ cells to hemopoietic growth factors and remodeling of cytokine network
    • Bagnara GP, Bonsi L, Strippoli P, et al. Hemopoiesis in healthy old people and centenarians: well-maintained responsiveness of CD34+ cells to hemopoietic growth factors and remodeling of cytokine network. J Gerontol A Biol Sci Med Sci 2000; 55: B61-6.
    • (2000) J Gerontol A Biol Sci Med Sci , vol.55 , pp. 61-66
    • Bagnara, G.P.1    Bonsi, L.2    Strippoli, P.3
  • 110
    • 84870741421 scopus 로고    scopus 로고
    • Age-related differences in the expression of circulating microRNAs: MiR-21 as a new circulating marker of inflamm-aging
    • Olivieri F, Spazzafumo L, Santini G, et al. Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflamm-aging. Mech Ageing Dev 2012; 133(11-12): 675-85.
    • (2012) Mech Ageing Dev , vol.133 , Issue.11-12 , pp. 675-685
    • Olivieri, F.1    Spazzafumo, L.2    Santini, G.3
  • 111
    • 84864503916 scopus 로고    scopus 로고
    • MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
    • Fabbri M, Paone A, Calore F, Galli R, et al. MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc Natl Acad Sci USA 2012; 109(31): E2110-6.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.31 , pp. 2110-2116
    • Fabbri, M.1    Paone, A.2    Calore, F.3    Galli, R.4
  • 112
    • 80054882112 scopus 로고    scopus 로고
    • MicroRNA 21 regulates the proliferation of human adipose tissue-derived mesenchymal stem cells and high-fat diet-induced obesity alters microRNA 21 expression in white adipose tissues
    • Kim YJ, Hwang SH, Cho HH, et al. MicroRNA 21 regulates the proliferation of human adipose tissue-derived mesenchymal stem cells and high-fat diet-induced obesity alters microRNA 21 expression in white adipose tissues. J Cell Physiol 2012; 227: 183-93.
    • (2012) J Cell Physiol , vol.227 , pp. 183-193
    • Kim, Y.J.1    Hwang, S.H.2    Cho, H.H.3
  • 113
    • 77950199929 scopus 로고    scopus 로고
    • Age-related inflammation: The contribution of different organs, tissues and systems. How to face it for therapeutic approaches
    • Cevenini E, Caruso C, Candore G, et al. Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches. Curr Pharm Des 2010; 16: 609-18.
    • (2010) Curr Pharm Des , vol.16 , pp. 609-618
    • Cevenini, E.1    Caruso, C.2    Candore, G.3
  • 114
    • 0033911488 scopus 로고    scopus 로고
    • Inflammaging. An evolutionary perspective on immunosenescence
    • Franceschi C, Bonafè M, Valensin S, Olivieri F, et al. Inflammaging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000; 908: 244-54.
    • (2000) Ann N Y Acad Sci , vol.908 , pp. 244-254
    • Franceschi, C.1    Bonafè, M.2    Valensin, S.3    Olivieri, F.4
  • 115
    • 84871805883 scopus 로고    scopus 로고
    • Centenarians, but not octogenarians, up-regulate the expression of microRNAs
    • Serna E, Gambini J, Borras C, et al. Centenarians, but not octogenarians, up-regulate the expression of microRNAs. Sci Rep 2012; 2: 961.
    • (2012) Sci Rep , vol.2
    • Serna, E.1    Gambini, J.2    Borras, C.3
  • 116
    • 84864338208 scopus 로고    scopus 로고
    • Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing
    • Gombar S, Jung HJ, Dong F, et al. Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing. BMC Genomics 2012; 13(1): 353.
    • (2012) BMC Genomics , vol.13 , Issue.1
    • Gombar, S.1    Jung, H.J.2    Dong, F.3
  • 117
    • 79952749156 scopus 로고    scopus 로고
    • DNA methyltransferase 1, cytosine methyla-tion and cytosine hydroxymethylation in mammalian mitochondria
    • Shock LS, Thakkar PV, Peterson EJ, et al. DNA methyltransferase 1, cytosine methyla-tion and cytosine hydroxymethylation in mammalian mitochondria. PNAS 2011; 108: 3630-5.
    • (2011) PNAS , vol.108 , pp. 3630-3635
    • Shock, L.S.1    Thakkar, P.V.2    Peterson, E.J.3
  • 118
    • 11144332565 scopus 로고    scopus 로고
    • Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
    • Shi Y, Lan F, Matson C, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004; 119: 941-53.
    • (2004) Cell , vol.119 , pp. 941-953
    • Shi, Y.1    Lan, F.2    Matson, C.3
  • 119
    • 84860586157 scopus 로고    scopus 로고
    • Mitochondrial regulation of epigenetics and its role in human diseases
    • Minocherhomji S, Tollefsbol TO, Singh KK. Mitochondrial regulation of epigenetics and its role in human diseases. Epigenetics 2012; 7: 326-34.
    • (2012) Epigenetics , vol.7 , pp. 326-334
    • Minocherhomji, S.1    Tollefsbol, T.O.2    Singh, K.K.3
  • 120
    • 49749121841 scopus 로고    scopus 로고
    • A novel role for mitochondria in regulating epigenetic modification in the nucleus
    • Smiraglia DJ, Kulawiec M, Bistulfi GL, et al. A novel role for mitochondria in regulating epigenetic modification in the nucleus. Cancer Biol Ther 2008; 7: 1182-90.
    • (2008) Cancer Biol Ther , vol.7 , pp. 1182-1190
    • Smiraglia, D.J.1    Kulawiec, M.2    Bistulfi, G.L.3
  • 121
    • 84862149788 scopus 로고    scopus 로고
    • Aging of the human metaorganism: The microbial counterpart
    • Biagi E, Candela M, Fairweather-Tait S, et al. Aging of the human metaorganism: the microbial counterpart. Age (Dordr) 2012; 34: 247-67.
    • (2012) Age (Dordr) , vol.34 , pp. 247-267
    • Biagi, E.1    Candela, M.2    Fairweather-Tait, S.3
  • 123
    • 84866146940 scopus 로고    scopus 로고
    • Diversity, stability and resilience of the human gut microbiota
    • Lozupone CA, Stombaugh JI, Gordon JI, et al. Diversity, stability and resilience of the human gut microbiota. Nature 2012; 489: 220-30.
    • (2012) Nature , vol.489 , pp. 220-230
    • Lozupone, C.A.1    Stombaugh, J.I.2    Gordon, J.I.3
  • 124
    • 84876913132 scopus 로고    scopus 로고
    • Role of the gut microbiota in immunity and inflammatory disease
    • Kamada N, Seo S, Chen GY, Gabriel Núñez. Role of the gut microbiota in immunity and inflammatory disease. Nature Rev Immunol 2013; 13: 321-35.
    • (2013) Nature Rev Immunol , vol.13 , pp. 321-335
    • Kamada, N.1    Seo, S.2    Chen, G.Y.3    Núñez, G.4
  • 125
    • 84877145046 scopus 로고    scopus 로고
    • Gut-brain axis: How the microbiome influences anxiety and depression
    • Foster JA, McVey Neufeld KA. Gut-brain axis: how the microbiome influences anxiety and depression. Trends Neurosci. 2013; 36: 305-12.
    • (2013) Trends Neurosci , vol.36 , pp. 305-312
    • Foster, J.A.1    McVey Neufeld, K.A.2
  • 126
    • 77955602581 scopus 로고    scopus 로고
    • Through ageing, and beyond: Gut microbiota and inflammatory status in seniors and centenarians
    • Biagi E, Nylund L, Candela M, et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One 2010; 5(5): e10667.
    • (2010) PLoS One , vol.5 , Issue.5
    • Biagi, E.1    Nylund, L.2    Candela, M.3
  • 129
    • 84924171409 scopus 로고    scopus 로고
    • The Challenges in Moving from Ageing to Successful Longevity
    • Kolovou G, Barzilai N, Caruso C, et al. The Challenges in Moving from Ageing to Successful Longevity. Current Vasc Pharmacol 2014; 12(5): 662-73.
    • (2014) Current Vasc Pharmacol , vol.12 , Issue.5 , pp. 662-673
    • Kolovou, G.1    Barzilai, N.2    Caruso, C.3
  • 130
    • 84880397970 scopus 로고    scopus 로고
    • Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: A proof of principle on type 2 diabetes
    • Garagnani P, Giuliani PC, et al. Centenarians as super-controls to assess the biological relevance of genetic risk factors for common age-related diseases: A proof of principle on type 2 diabetes. Aging 2013; 5(5): 373-85.
    • (2013) Aging , vol.5 , Issue.5 , pp. 373-385
    • Garagnani, P.1    Giuliani, P.C.2
  • 131
    • 84859933264 scopus 로고    scopus 로고
    • Genetics of longevity: Data from the studies on Sicilian centenarians
    • Balistreri CR, Candore G, Accardi G, et al. Genetics of longevity: data from the studies on Sicilian centenarians. Immun Ageing 2012; 9(1): 8.
    • (2012) Immun Ageing , vol.9 , Issue.1
    • Balistreri, C.R.1    Candore, G.2    Accardi, G.3
  • 132
    • 84924140282 scopus 로고    scopus 로고
    • Cellular senescence in ageing, age-related disease and longevity
    • Sikora E, Bielak-Zmijewska A, Mosieniak G. Cellular senescence in ageing, age-related disease and longevity. Current Vasc Pharmacol 2014; 12(5): 698-706.
    • (2014) Current Vasc Pharmacol , vol.12 , Issue.5 , pp. 698-706
    • Sikora, E.1    Bielak-Zmijewska, A.2    Mosieniak, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.