Centenarian offspring: A model for understanding longevity

Current Vascular Pharmacology

Volumn 12, Issue 5, 2014, Pages 718-725

  Balistreri, Carmela Rita ^a   Candore, Giuseppina ^a   Accardi, Giulia ^a   Buffa, Silvio ^a   Bulati, Matteo ^a   Martorana, Adriana ^a   Colonna Romano, Giuseppina ^a   Lio, Domenico ^a   Caruso, Calogero ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Ageing; Cardiovascular profile; Centenarian offspring; Centenarians; Genetic background; Immunosenescence; Memory decline

Indexed keywords

HEAT SHOCK PROTEIN 70; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMMUNOGLOBULIN M; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MITOCHONDRIAL DNA; TELOMERASE REVERSE TRANSCRIPTASE;

ACUTE HEART INFARCTION; AGING; ALZHEIMER DISEASE; ARTICLE; B LYMPHOCYTE; CARDIOVASCULAR RISK; CD8+ T LYMPHOCYTE; CEREBROVASCULAR ACCIDENT; DEMENTIA; GENE MUTATION; GENETIC VARIABILITY; GENOTYPING TECHNIQUE; HOMOZYGOSITY; HUMAN; HYPERTENSION; IMMUNE DEFICIENCY; ISCHEMIC HEART DISEASE; LONGEVITY; MEMORY; MEMORY DISORDER; NATURAL KILLER CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; PROGENY; VERY ELDERLY; ANIMAL; BIOLOGICAL MODEL; CARDIOVASCULAR DISEASE; GENETICS; PHYSIOLOGY; PSYCHOLOGY; QUALITY OF LIFE;

AGING; ALZHEIMER DISEASE; ANIMALS; CARDIOVASCULAR DISEASES; HUMANS; LONGEVITY; MODELS, BIOLOGICAL; QUALITY OF LIFE;

EID: 84922652623     PISSN: 15701611     EISSN: 18756212     Source Type: Journal    
DOI: 10.2174/1570161111666131219113544     Document Type: Article

References (74)

1. Farrelly C. 'Positive biology' as a new paradigm for the medical sciences, Focusing on people who live long, happy, healthy lives might hold the key to improving human well-being. EMBO Rep 2012: 13: 186-8.
2. Caruso C, Passarino G, Puca A, Scapagnini G. "Positive biology": the centenarian lesson. Immun Ageing 2012: 9: 5.
3. O'Hara AM, Shanahan P. The gut llora as a forgotten organ. EMBO Rep 2006: 7: 688-93.
4. Atzmon G, Schechler C, Greiner W, Davidson D, Rennert G, Barzilai N. Clinical phenotype of families with longevity. J Am Gerialr Soc 2004: 52: 274-7.
5. Perls IT. Bubrick E, Wager CO, Vijg J, Kniglyak I. Siblings of centenarians live longer. Lancet 1998: 351: 1560.
6. Shimizu K, Takeda S, Noji H. et al. Dietary patterns and further survival in Japanese centenarians. J Nuir Sci Vitam (Tokyo) 2003; 49: 133-38.
7. Schoenmaker M, de Craen AJ, dc Meijer PH, et al. Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study. Eur J Hum Genet 2006; 14: 79-84.
8. Palsdottir A, Helgason A, Palsson S, et al. A drastic reduction in the life span of cystatin C L68Q carriers due to life-style changes during the last two centuries. PLoS Genet 2008: 4: e1000099.
9. Carmelli D, Andersen S. A longevity study of twins in the Mormon genealogy. Prog Clin Biol Res 1981: 69A:81-3.
10. Darviri C, Demakakos P, Tigani X. et al. Psychosocial dimensions of exceptional longevity: a qualitative exploration of centenarians' experiences, personality, and life strategies. Int J Aging Hum Dev 2009:69: 101-18.
11. Mitt R. Young-Xu Y. Silver M. Perls T. Centenarians: the older you get the healthier you have been. Lancet 1999: 354: 652.
12. Samuelsson SM, Alfredson BB, Hagherg B. et al. The Swedish Centenarian Study: a multidisciplinary study of five consecutive cohorts at the age of 100. Int J Aging I him Dev 1997: 45: 223-53.
13. Willcox DC. Wilicox BJ. Shimajiri S. Kurechi S. Suzuki M. Ageing gracefully: a retrospective analysis of functional status in Oki-nawan centenarians. Am J Geriatr Psychiatry 2007: 15: 252-5.
14. Terry DF. Wilcox M, McCormick MA, Lawler E, Perls TT. Cardiovascular advantages among the offspring of centenarians. J Gerontol A Biol Sci Med Sci 2003: 58: M425-31.
15. Terry DF, Wilcox MA, McCormick MA, Perls TT. Cardiovascular disease delay in centenarian offspring. J Gerontol A Biol Sci Med Sci 2004: 59: 385-9.
16. Terry DF. Wilcox MA. McCormick MA. et al. Lower all-cause cardiovascular, and cancer mortality in centenarians' offspring. J Am Geriatr Soc 2004; 52: 2074-6.
17. Adams ER. Nolan VG. Andersen SL, Perls TT, Terry DF. Centenarian offspring: start healthier and stay healthier. J Am Geriatr Soc 2008: 56: 2089-92.
18. Newman A, Glynn N, Taylor C, et al. Health and function of participants in the Long Life Family Study: a comparison with other cohorts. Ageing (Albany NY) 2011: 3: 63-76.
19. Barzilai N, Atzmon G, Sehechter C, et al. Unique lipoprotein phenotype and genotype associated with exceptional longevity. J Am Med Assoc 2003: 290: 2030-10.
20. Barzilai N, Gabricly I, Gabricly M, Iankowitz N, Sorkin JD. Offspring of centenarians have a favorable lipid profile. J Am Geriatr Soc 2001: 49: 76-9.
21. Atzmon G, Rincon M, Rabizadeh P, Barzilai N. Biological evidence for inheritance of exceptional longevity. Mech Ageing Dev 2005: 126:341-5.
22. Li WW, Dammermun MM, Smith JD, et al. Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia. J Clin Invest 1995:96:2601-5
23. Sehechter CB, Barzilai N, Crandall JP, Atzmon G, Cholestery I ester transfer protein (CETP) genotype and reduced CETP levels associated with decreased prevalence of hypertension. Mayo Clin Proe 2010: 85: 522-6
24. Atzmon G, Rincon M, Sehechter CB, et al. Lipoprotein genotype and conserved pathway for exceptional longevity in humans. PLoS Biol 2006; 4: e113.
25. Terry DF, McCormick M, Andersen S. et al. Cardiovascular disease delay in centenarian offspring: role of heat shock proteins. Ann N Y Acad Sci 2004; 1019: 502-5.
26. Rea IM, McNerlnn S, Pocklcy AG. Serum heat shock protein and anti-heat shock protein antibody levels in aging. Exp Gerontol 2001:36:341-52.
27. Jin X, Wang R, Xiao C, et al. Serum and lymphocyte levels of heat shock protein 70 in aging: a study in the normal Chinese population. Cell Stress Chaperones 2004; 9: 69-75.
28. Terry DF, Wyszynski DF, Nolan VG, et al. Serum heal shock protein 70 level as a biomarker of exceptional longevity. Mech Ageing Dev 2006: 127: 862-8.
29. Suh Y, Atzmon G, Cho MO. et al. Functionally significant insulin-like growth factor 1 receptor mutations in centenarians. Proc Natl Acad Sci USA 2008: 105: 3438-42.
30. Claeysen S, Cochet M, Donneger R, Dumuis A, Bockaert J, Giannoni P. Alzheimer culprits: cellular crossroads and interplay. Cell Signal 2012: 24: 1831-40
31. James BD, Wilson RS, Barnes LL, Bennett DA. Late-life social activity and cognitive decline in old age. J Int Neuropsychol Soc 2011: 17:998-1005.
32. Lipton RB, Hirsch J, Katz MJ, et al. Exceptional parental longevity associated with lower risk of Alzheimer's disease and memory decline. J Am Geriatr Soc 2010; 58: 1043-9.
33. Barrel S, Cosentino S, Costa R. et al. Cognitive function in families with exceptional survival. Neurobiol Ageing 2012: 33: 619.el-7.
34. Hagberg B. Samuelsson G. Survival alter 100 years of age: a multivariate model of exceptional survival in Swedish centenarians. J Gerontol A Biol Sci Med Sci 2008: 63: 1219-26.
35. Yates LB, Djousse I, Kurth T, Buring JE. Gaziano JM. Exceptional longevity in men: modifiable factors associated with survival and function to age 90 years. Arch Intern Med 2008; 168: 284-90.
36. Franceschi C, Monti D, Sansoni P, Cossarizza A. The immunology of exceptional individuals: the lesson of centenarians. Immunol Today 1995a: 16: 12-6.
37. Franceschi C, Monti D, Barbieri D, et al. Immunosenescence in humans: deterioration or remodelling? Int Rev Immunol 1995b: 12: 57-74.
38. Pawelec G, Akbar A, Caniso C, Solana R, Grubeek-Loebenstein B, Wikby A. Human immunosenescence: is it infectious? Immunol Rev 2005: 205: 257-68.
39. Solana R, Pawelec G, Tarazona R. Aging and innate immunity. Immunity 2006;24:491-4.
40. Sridharan A, Esposo M, Kaushal K, et al Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CDS T cell immunity. Age (Dordr) 2011: 33: 363-76.
41. Gupta S, Bi R, Su K, Yel L, Chiplunkar S, Gollapudi S. Characterization of naïve, memory and effector CD8+ T cells: effect of age. Exp Gerontol 2004: 39:545-50.
42. Chong Y, Ikcmatsu H, Yamaji K. et al. CD27(-) (memory) B cell decrease and apoptosis-resistant-CD27(-) (naive) B cell increase in aged humans: implications for age-related peripheral B cell developmental disturbances. Int Immunol 2005: 17: 383-90.
43. Colonna-Romano G, Bulati M, Aquino A. et al. A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood Of elderly people. Mech Ageing Develop 2009: 130: 681-90.
44. Derhovanessian E, Maier AB, Beck R, et al. Hallmark features of immunosenescence are absent in familial longevity. Immunol 2010. 185:4618-24.
45. Frasca D, Landin AM, Lechner SC, Ryan JG. et al. Aging down-regulates the transcription factor E2A, activation-induced cytidinedeaminase, and Ig class switch in human B cells. J Immunol 2008: 15: 180:5283-90.
46. Shi Y, Yamazaki T, Okubo Y, Uehara Y, Sugane K, Agemalsu K. Regulation of aged humoral immune defense against pneumococcal bacteria by IgM memory B cell. J Immunol 2005: 175: 3262-7.
47. List F, Candore G, Modica MA et al. Study of serum immunoglobulin levels in elderly persons that provides new insights into B cell immunosenescence. Ann NY Acad Sci 2006; 1089: 487-95.
48. Buffa S, Bulali M, Pellieano M, et al. B cell immunosenescence: different features of naive and memory B cells in elderly. Bioger-onlol 2011: 12:473-83.
49. Bulati M, Buffa S, Candore G. et al. B cells and immunosenescence: a focus on lgGHgD-CD27- (DN) B cells in aged humans. Ageing Res Rev 2011: 10: 274-84.
50. Mariotti S, Sansoni P, Barbesino G. et al. Thyroid and other organ-specific auto antibodies in healthy centenarians. Lancet 1992: 339: 1506-8.
51. Sansoni P, Cossarizza A, Brianti V. et al. Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians. Blood 1993:82:2767-73.
52. Cossarizza A, Ortolani C, Paganelli R, et al. CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory. Mech Ageing Dev 1996:86: 173-95.
53. Candore G, Di Lorenzo G, Mansueto P. et al. Prevalence of organ-specific and non organ-specific auto antibodies in healthy centenarians. Mech Ageing Dev 1997:94: 183-90.
54. Bagnara GP, Bonsi L, Strippoli P. et al. Hemopoiesis in healthy old people and centenarians: well-maintained responsiveness of CD34 cells lo hemopoietic growth factors and remodelling of cytokine network. J Gerontol A Biol Sci Med Sci 2000; 55: B61-6.
55. Baggio G, Donazzan S, Monti D. et al. Lipoprotein(a) and lipoprotein profile in healths' centenarians: a reappraisal of vascular risk factors. FASEB J 1998: 12:433-7.
56. Passeri G, Pini G, Troiano L, et al. Low vitamin D status, high bone turnover, and bone fractures in centenarians. J Clin Endocrinol Metab 2003: 88: 5109-15.
57. Coppola R, Mari D, Lattuada A, Franccschi C. Von Willebrand factor in Italian centenarians. Haematologica 2003: 88: 39-13.
58. Capri M, Salvioli S, Monti D. et al. Human longevity within an evolutionary perspective: the peculiar paradigm of a post-reproductive genetics. Exp Gerontol 2008: 43: 53-60.
59. Rca SL, Wu D, Cypser JR, Vaupel JW. Johnson TE. A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditisclegans. Nat Genet 2005: 37: 894-8.
60. Cevenini E, Invidia L, Lcscai F, et al. Human models of aging and longevity. Expert Opin Biol Ther 2008: 8: 1393-1405.
61. Colonna-Romano G, Buffa S, Bulati M. et al. B cells compartment in centenarian offspring and old people. Curr Pharm Des 2010: 16: 604-8.
62. Cancro MP, Hao Y, Scholz JL. et al. B cells and ageing: molecules and mechanisms. Trends Immunol 2009: 30: 313-8.
63. Finch CE. The Biologv of Aging (Academic Press, Burlington. MA). 2007.
64. Oescburg H, de Boer RA, van Gilst WH, van der Harst P. Telomere biology in healthy aging and disease. Pflugers Arch 2010: 459: 259-68.
65. Zhu H, Belcher M, van der Harst P. Healthy aging and disease: role for telomere biology? Clin Sci (Lond) 2011; 120: 427-40.
66. Atzmon G, Cho M, Cawihon RM. et al. Evolution in health and medicine Sackler colloquium: genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci USA 2010: l07(Suppl I): 1710-7.
67. Calado R, Young N. Telomeres in disease. FI000 Med Rep 2012: 4:8.
68. Rose G, Passarino G, Scornaienchi V. et al. The mitochondrial DNA control region shows genetically correlated levels of helero-plusmyinlcukocyles of centenarians and their offspring. BMC Genomic's 2007; 8:293.
69. Iwata N, Zhang J, Atzmon G. et al. Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmicmt DNA mutation adjacent to replication origin frequently remodeled in Italian centenarians. Mitochondrion 2007: 7: 267-72.
70. Gentilini D, Mari D, Castaldi D, et al. Role of epigenetics in human aging and longevity: genome-wide DNA mcthylation profile in centenarians and centenarians' offspring. Age (Dordr) 2013: 35(5): 1961-73.
71. Haendeler J, Dröse S, Büchner N. et al. Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arterioscler Thromb Vase Biol 2009; 29: 929-35.
72. Sharnia NK, Reyes A, Green P, et al. Human telomerase acts as ahTR-independenl reverse transcriptase in mitochondria. Nucleic-Acids Res 2012:40: 712-25.
73. Balistreri CR, Candore G, Accardi G, et al. Genetics of longevity: data from the studies on Sicilian centenarians. Immun Ageing 2012:9:8
74. Gentilini D, Castaldi D, Mari D, et al. Age-dependent skewing of X chromosome inactivation appears delayed in centenarians' oil-spring, Is there a role for allelic imbalance in healthy aging and longevity? Aging Cell 2012: 11: 277-83.