Apolipoprotein E and familial longevity

Neurobiology of Aging

Volumn 34, Issue 4, 2013, Pages 1287-1291

  Schupf, Nicole ^a   Barral, Sandra ^a   Perls, Thomas ^b   Newman, Anne ^c   Christensen, Kaare ^d,e   Thyagarajan, Bharat ^f   Province, Michael ^g   Rossi, Winifred K ^h   Mayeux, Richard ^a  

^a NewYork Presbyterian Hospital   (United States)

^b BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^c GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^d UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^e ODENSE UNIVERSITY HOSPITAL   (Denmark)

^f UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^g WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

APOE; Exceptional longevity; Familial longevity; Offspring; TOMM40

Indexed keywords

APOLIPOPROTEIN E;

ADULT; ARTICLE; COGNITION; CONTROLLED STUDY; CORRELATION ANALYSIS; DENMARK; DIABETES MELLITUS; ETHNICITY; FAMILY HISTORY; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC VARIABILITY; HEART INFARCTION; HUMAN; HYPERTENSION; LONGEVITY; MAJOR CLINICAL STUDY; MALE; PARKINSON DISEASE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED STATES;

APOLIPOPROTEINS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LONGEVITY; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SURVIVAL ANALYSIS; SURVIVAL RATE; UNITED STATES;

EID: 84872298321     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.08.019     Document Type: Article

References (32)

1. Bader G., Zuliani G., Kostner G.M., Fellin R. Apolipoprotein E polymorphism is not associated with longevity or disability in a sample of Italian octo- and nonagenarians. Gerontology 1998, 44:293-299.
2. Barrett J.C. Haploview: visualization and analysis of SNP genotype data. Cold Spring Harb. Protoc. 2009, 2009. pdb.ip71.
3. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265.
4. Davignon J., Gregg R.E., Sing C.F. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 1988, 8:1-21.
5. De Benedictis G., Tan Q., Jeune B., Christensen K., Ukraintseva S.V., Bonafe M., Franceschi C., Vaupel J.W., Yashin A.I. Recent advances in human gene-longevity association studies. Mech. Ageing Dev. 2001, 122:909-920.
6. Deelen J., Beekman M., Uh H.W., Helmer Q., Kuningas M., Christiansen L., Kremer D., van der Breggen R., Suchiman H.E., Lakenberg N., van den Akker E.B., Passtoors W.M., Tiemeier H., van Heemst D., de Craen A.J., Rivadeneira F., de Geus E.J., Perola M., van der Ouderaa F.J., Gunn D.A., Boomsma D.I., Uitterlinden A.G., Christensen K., van Duijn C.M., Heijmans B.T., Houwing-Duistermaat J.J., Westendorp R.G., Slagboom P.E. Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited. Aging Cell 2011, 10:686-698.
7. Ewbank D.C. Mortality differences by APOE genotype estimated from demographic synthesis. Genet. Epidemiol. 2002, 22:146-155.
8. Ewbank D.C. Differences in the association between apolipoprotein E genotype and mortality across populations. J. Gerontol. A Biol. Sci. Med. Sci. 2007, 62:899-907.
9. Finch C.E., Tanzi R.E. Genetics of aging. Science 1997, 278:407-411.
10. Galinsky D., Tysoe C., Brayne C.E., Easton D.F., Huppert F.A., Dening T.R., Paykel E.S., Rubinsztein D.C. Analysis of the apo E/apo C-I, angiotensin converting enzyme and methylenetetrahydrofolate reductase genes as candidates affecting human longevity. Atherosclerosis 1997, 129:177-183.
11. Gudmundsson H., Gudbjartsson D.F., Frigge M., Gulcher J.R., Stefansson K. Inheritance of human longevity in Iceland. Eur. J. Hum. Genet. 2000, 8:743-749.
12. Herskind A.M., McGue M., Holm N.V., Sorensen T.I., Harvald B., Vaupel J.W. The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900. Hum. Genet. 1996, 97:319-323.
13. Hirose N., Homma S., Arai Y., Kawamura M., Hasegawa H., Ishida H., Shimizu K., Osono Y., Homma A., Nakamura Y. Tokyo Centenarian Study. 4. Apolipoprotein E phenotype in Japanese centenarians living in the Tokyo Metropolitan area [in Japanese]. Nippon Ronen Igakkai Zasshi 1997, 34:267-272.
14. Jacobsen R., Martinussen T., Christiansen L., Jeune B., Andersen-Ranberg K., Vaupel J.W., Christensen K. Increased effect of the ApoE gene on survival at advanced age in healthy and long-lived Danes: two nationwide cohort studies. Aging Cell 2010, 9:1004-1009.
15. Jian-Gang Z., Yong-Xing M., Chuan-Fu W., Pei-Fang L., Song-Bai Z., Nui-Fan G., Guo-Yin F., Lin H. Apolipoprotein E and longevity among Han Chinese population. Mech. Ageing Dev. 1998, 104:159-167.
16. Kerber R.A., O'Brien E., Smith K.R., Cawthon R.M. Familial excess longevity in Utah genealogies. J. Gerontol. A Biol. Sci. Med. Sci. 2001, 56:B130-B139.
17. Kervinen K., Savolainen M.J., Salokannel J., Hynninen A., Heikkinen J., Ehnholm C., Koistinen M.J., Kesaniemi Y.A. Apolipoprotein E and B polymorphisms-longevity factors assessed in nonagenarians. Atherosclerosis 1994, 105:89-95.
18. Lee J.H., Tang M.X., Schupf N., Stern Y., Jacobs D.M., Tycko B., Mayeux R. Mortality and apolipoprotein E in Hispanic, African-American, and Caucasian elders. Am. J. Med. Genet. 2001, 103:121-127.
19. Louhija J., Miettinen H.E., Kontula K., Tikkanen M.J., Miettinen T.A., Tilvis R.S. Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians. Arterioscler. Thromb. 1994, 14:1084-1089.
20. McGue M., Vaupel J.W., Holm N., Harvald B. Longevity is moderately heritable in a sample of Danish twins born 1870-1880. J. Gerontol. 1993, 48:B237-B244.
21. McKay G.J., Silvestri G., Chakravarthy U., Dasari S., Fritsche L.G., Weber B.H., Keilhauer C.N., Klein M.L., Francis P.J., Klaver C.C., Vingerling J.R., Ho L., De Jong P.T., Dean M., Sawitzke J., Baird P.N., Guymer R.H., Stambolian D., Orlin A., Seddon J.M., Peter I., Wright A.F., Hayward C., Lotery A.J., Ennis S., Gorin M.B., Weeks D.E., Kuo C.L., Hingorani A.D., Sofat R., Cipriani V., Swaroop A., Othman M., Kanda A., Chen W., Abecasis G.R., Yates J.R., Webster A.R., Moore A.T., Seland J.H., Rahu M., Soubrane G., Tomazzoli L., Topouzis F., Vioque J., Young I.S., Fletcher A.E., Patterson C.C. Variations in apolipoprotein E frequency with age in a pooled analysis of a large group of older people. Am. J. Epidemiol. 2011, 173:1357-1364.
22. Mitchell B.D., Hsueh W.C., King T.M., Pollin T.I., Sorkin J., Agarwala R., Schaffer A.A., Shuldiner A.R. Heritability of life span in the Old Order Amish. Am. J. Med. Genet. 2001, 102:346-352.
23. Nebel A., Kleindorp R., Caliebe A., Nothnagel M., Blanche H., Junge O., Wittig M., Ellinghaus D., Flachsbart F., Wichmann H.E., Meitinger T., Nikolaus S., Franke A., Krawczak M., Lathrop M., Schreiber S. A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals. Mech. Ageing Dev. 2011, 132:324-330.
24. Pedersen C.B., Gotzsche H., Moller J.O., Mortensen P.B. The Danish Civil Registration System. A cohort of eight million persons. Dan. Med. Bull. 2006, 53:441-449.
25. Perls T.T., Wilmoth J., Levenson R., Drinkwater M., Cohen M., Bogan H., Joyce E., Brewster S., Kunkel L., Puca A. Life-long sustained mortality advantage of siblings of centenarians. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:8442-8447.
26. Rebeck G.W., Perls T.T., West H.L., Sodhi P., Lipsitz L.A., Hyman B.T. Reduced apolipoprotein epsilon 4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals. Neurology 1994, 44:1513-1516.
27. Schachter F., Faure-Delanef L., Guenot F., Rouger H., Froguel P., Lesueur-Ginot L., Cohen D. Genetic associations with human longevity at the APOE and ACE loci. Nat. Genet. 1994, 6:29-32.
28. Sebastiani P., Hadley E.C., Province M., Christensen K., Rossi W., Perls T.T., Ash A.S. A family longevity selection score: ranking sibships by their longevity, size, and availability for study. Am. J. Epidemiol. 2009, 170:1555-1562.
29. Sebastiani P., Solovieff N., Dewan A.T., Walsh K.M., Puca A., Hartley S.W., Melista E., Andersen S., Dworkis D.A., Wilk J.B., Myers R.H., Steinberg M.H., Montano M., Baldwin C.T., Hoh J., Perls T.T. Genetic signatures of exceptional longevity in humans. PLoS One 2012, 7:e29848.
30. Soerensen, M., Dato, S., Tan, Q., Thinggaard, M., Kleindorp, R., Beekman, M., Suchiman, H.E., Jacobsen, R., Mcgue, M., Stevnsner, T., Bohr, V.A., De Craen, A.J., Westendorp, R.G., Schreiber, S., Slagboom, P.E., Nebel, A., Vaupel, J.W., Christensen, K., Christiansen, L. Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity. Age (Dordr) 2012, January 12 [Epub ahead of print].
31. Tan Q., Christiansen L., Christensen K., Kruse T.A., Bathum L. Apolipoprotein E genotype frequency patterns in aged Danes as revealed by logistic regression models. Eur. J. Epidemiol. 2004, 19:651-656.
32. van Bockxmeer F.M. ApoE and ACE genes: impact on human longevity. Nat. Genet. 1994, 6:4-5.