Does the longevity of one or both parents influence the health status of their offspring?

Experimental Gerontology

Volumn 48, Issue 4, 2013, Pages 395-400

  Gueresi, P ^a   Miglio, R ^a   Monti, D ^b   Mari, D ^c,d   Sansoni, P ^e   Caruso, C ^f   Bonafede, E ^a   Bucci, L ^a   Cevenini, E ^a   Ostan, R ^a   Palmas, M G ^a   Pini, E ^a   Scurti, M ^a   Franceschi, C ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^e UNIVERSITY OF PARMA   (Italy)

^f UNIVERSITY OF PALERMO   (Italy)

Author keywords

Centenarians' offspring; Familial longevity; Functional status; Health status; Healthy aging

Indexed keywords

AGE DISTRIBUTION; AGED; ARTICLE; CAUSE OF DEATH; DEMOGRAPHY; DRUG USE; FAMILY ASSESSMENT; FEMALE; FUNCTIONAL STATUS; HEALTH STATUS; HEREDITY; HUMAN; ITALY; LONGEVITY; MALE; PARENT; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; PROGENY; QUESTIONNAIRE; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION; SEX DIFFERENCE; SOCIAL STATUS; SURVIVAL TIME;

ACTIVITIES OF DAILY LIVING; ADULT CHILDREN; AGED; AGED, 80 AND OVER; CENSUSES; DEMOGRAPHY; FEMALE; GERIATRIC ASSESSMENT; HEALTH STATUS DISPARITIES; HUMANS; ITALY; LIFE EXPECTANCY; LONGEVITY; MALE; PARENTS; QUESTIONNAIRES; REGRESSION ANALYSIS; RISK FACTORS; SOCIOECONOMIC FACTORS; SURVIVAL ANALYSIS;

EID: 84874704289     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2013.02.004     Document Type: Article

References (25)

1. Adams E.R., Nolan V.G., Andersen S.L., Perls T.T., Terry D.F. Centenarian offspring: start healthier and stay healthier. J. Am. Geriatr. Soc. 2008, 56(11):2089-2092.
2. Atzmon G., Schechter C., Greiner W., Davidson D., Rennert G., Barzilai N. Clinical phenotype of families with longevity. J. Am. Geriatr. Soc. 2004, 52(2):274-277.
3. Cevenini E., Bellavista E., Tieri P., Castellani G., Lescai F., Francesconi M., Mishto M., Santoro A., Valensin S., Salvioli S., Capri M., Zaikin A., Monti D., de Magalhães J.P., Franceschi C. Systems biology and longevity: an emerging approach to identify innovative anti-aging targets and strategies. Curr. Pharm. Des. 2010, 16(7):802-813.
4. Crimmins E.M., Kim J.K., Solé-Auró A. Gender differences in health: results from SHARE, ELSA and HRS. Eur. J. Public Health 2011, 21(1):81-91.
5. De Benedictis G., Franceschi C. The unusual genetics of human longevity. Sci. Aging Knowledge Environ. 2006, 28(10):20.
6. Evert J., Lawler E., Bogan H., Perls T. Morbidity profiles of centenarians: survivors, delayers, and escapers. J. Gerontol. A Biol. Sci. Med. Sci. 2003, 58(3):232-237.
7. Franceschi C., Motta L., Valensin S., Rapisarda R., Franzone A., Berardelli M., Motta M., Monti D., Bonafé M., Ferrucci L., Deiana L., Pes G.M., Barbi C., Sartoni G., Gemelli C., Lescai F., Olivieri F., Marchegiani F., Cardelli M., Cavallone L., Gueresi P., Cossarizza A., Troiano L., Pini G., Sansoni P., Passeri G., Lisa R., Spazzafumo L., Amadio L., Giunta S., Stecconi R., Morresi R., Viticchi C., Mattace R., De Benedictis G., Baggio G., the Italian Multicenter Study on Centenarians (IMUSCE) Do men and women follow different trajectories to reach extreme longevity?. Aging Clin. Exp. Res. 2000, 12:77-84.
8. Franceschi C., Bezrukov V., Blanché H., Bolund L., Christensen K., de Benedictis G., Deiana L., Gonos E., Hervonen A., Yang H., Jeune B., Kirkwood T.B., Kristensen P., Leon A., Pelicci P.G., Peltonen L., Poulain M., Rea I.M., Remacle J., Robine J.M., Schreiber S., Sikora E., Slagboom P.E., Spazzafumo L., Stazi M.A., Toussaint O., Vaupel J.W. Genetics of healthy aging in Europe: the EU-integrated project GEHA (Genetics of Healthy Aging). Ann. N. Y. Acad. Sci. 2007, 1100:21-45.
9. Franceschi C., Capri M., Monti D., Giunta S., Olivieri F., Sevini F., Panourgia M.P., Invidia L., Celani L., Scurti M., Cevenini E., Castellani G., Salvioli S. Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech. Ageing Dev. 2007, 128(1):92-105.
10. Gögele M., Pattaro C., Fuchsberger C., Minelli C., Pramstaller P.P., Wjst M. Heritability analysis of life span in a semiisolated population followed across four centuries reveals the presence of pleiotropy between life span and reproduction. J. Gerontol. A Biol. Sci. Med. Sci. 2011, 66(1):26-37.
11. Gueresi P., Troiano L., Minicuci N., Bonafé M., Pini G., Salvioli G., Carani C., Ferrucci L., Spazzafumo L., Olivieri F., Cavrini G., Valentini D., Franceschi C. The MALVA (MAntova LongeVA) Study: an investigation on people 98years of age and over in a province of Northern Italy. Exp. Gerontol. 2003, 38:1189-1197.
12. Human Mortality Database University of California, Berkeley (USA), and Max Planck Institute for Demographic Research (Germany) Available at. http://www.humanmortality.de.
13. Ling C.H., de Craen A.J., Slagboom P.E., Westendorp R.G., Maier A.B. Handgrip strength at midlife and familial longevity: The Leiden Longevity Study. Age (Dordr.) 2012, 34(5):1261-1268.
14. Olivieri F., Spazzafumo L., Antonicelli R., Marchegiani F., Cardelli M., Sirolla C., Galeazzi R., Giovagnetti S., Mocchegiani E., Franceschi C. Combination of biomarkers to predict mortality in elderly patients with myocardial infarction. Mech. Ageing Dev. 2008, 129(4):231-237.
15. Paolisso G., Gambardella A., Ammendola S., D'Amore A., Balbi V., Varricchio M., D'Onofrio F. Glucose tolerance and insulin action in healthy centenarians. Am. J. Physiol. 1996, 270:890-894.
16. Passeri G., Pini G., Troiano L., Vescovini R., Sansoni P., Passeri M., Gueresi P., Delsignore R., Pedrazzoni M., Franceschi C. Low vitamin D status, high bone turnover, and bone fractures in centenarians. J. Clin. Endocrinol. Metab. 2003, 88(11):5109-5115.
17. Perls T.T., Wilmoth J., Levenson R., Drinkwater M., Cohen M., Bogan H., Joyce E., Brewster S., Kunkel L., Puca A. Life-long sustained mortality advantage of siblings of centenarians. Proc. Natl. Acad. Sci. U. S. A. 2002, 99(12):8442-8447.
18. Salvioli S., Capri M., Bucci L., Lanni C., Racchi M., Uberti D., Memo M., Mari D., Govoni S., Franceschi C. Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53. Cancer Immunol. Immunother. 2009, 58(12):1909-1917.
19. Spazzafumo L., Olivieri F., Abbatecola A.M., Castellani G., Monti D., Lisa R., Galeazzi R., Sirolla C., Testa R., Ostan R., Scurti M., Caruso C., Vasto S., Vescovini R., Ogliari G., Mari D., Lattanzio F., Franceschi C. Remodelling of biological parameters during human ageing: evidence for complex regulation in longevity and in type 2 diabetes. Age (Dordr.) 2011, 16.
20. Terry D.F., Wilcox M., McCormick M.A., Lawler E., Perls T.T. Cardiovascular advantages among the offspring of centenarians. J. Gerontol. A Biol. Sci. Med. Sci. 2003, 58(5):425-431.
21. J. Gerontol. A Biol. Sci. Med. Sci. 2008, 63(7):706. Erratum in:.
22. Terry D.F., McCormick M., Andersen S., Pennington J., Schoenhofen E., Palaima E., Bausero M., Ogawa K., Perls T.T., Asea A. Cardiovascular disease delay in centenarian offspring: role of heat shock proteins. Ann. N. Y. Acad. Sci. 2004, 1019:502-505.
23. Terry D.F., Wilcox M.A., McCormick M.A., Pennington J.Y., Schoenhofen E.A., Andersen S.L., Perls T.T. Lower all-cause, cardiovascular, and cancer mortality in centenarians offspring. J. Am. Geriatr. Soc. 2004, 52(12):2074-2076.
24. Westendorp R.G., van Heemst D., Rozing M.P., Frölich M., Mooijaart S.P., Blauw G.J., Beekman M., Heijmans B.T., de Craen A.J., Slagboom P.E. Leiden Longevity Study Group, 2009. Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study. J. Am. Geriatr. Soc. 2009, 57(9):1634-1637.
25. Wijsman C.A., Rozing M.P., Streefland T.C., le Cessie S., Mooijaart S.P., Slagboom P.E., Westendorp R.G., Pijl H., van Heemst D., Leiden Longevity Study group Familial longevity is marked by enhanced insulin sensitivity. Aging Cell 2011, 10(1):114-121.