Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations

Mechanisms of Ageing and Development

Volumn 133, Issue 8, 2012, Pages 556-562

  Harries, Lorna W ^a   Fellows, Alexander D ^a   Pilling, Luke C ^a   Hernandez, Dena ^b   Singleton, Andrew ^b   Bandinelli, Stefania ^c   Guralnik, Jack ^d   Powell, Jonathan ^a   Ferrucci, Luigi ^b   Melzer, David ^a  

^a UNIVERSITY OF EXETER   (United Kingdom)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c Azienda Sanitaria di Firenze   (Italy)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Aging mechanisms; Human population; MTOR

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; POLYCYSTIN 1; S6 KINASE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; STAT3 PROTEIN; TRANSCRIPTION FACTOR FOXO; VASCULOTROPIN B;

ADOLESCENT; ADULT; AGED; AGING; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; FOXO GENE; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HIF1A GENE; HUMAN; MALE; PI3K GENE; PKC GENE; PKD1 GENE; PRIORITY JOURNAL; PTEN GENE; S6K GENE; SGK1 GENE; SIGNAL TRANSDUCTION; SREBF1 GENE; STAT3 GENE; VEGFB GENE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; APOPTOSIS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; ITALY; LIPID METABOLISM; LONGEVITY; MALE; MIDDLE AGED; NEOVASCULARIZATION, PHYSIOLOGIC; PROSPECTIVE STUDIES; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSCRIPTOME;

ANIMALIA;

EID: 84865401134     PISSN: 00476374     EISSN: 18726216     Source Type: Journal    
DOI: 10.1016/j.mad.2012.07.003     Document Type: Article

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