The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring

BMC Genomics

Volumn 8, Issue , 2007, Pages

  Rose, Giuseppina ^a   Passarino, Giuseppe ^a   Scornaienchi, Vittorio ^a   Romeo, Giuseppe ^a   Dato, Serena ^a   Bellizzi, Dina ^a   Mari, Vincenzo ^b   Feraco, Emidio ^b   Maletta, Raffaele ^c   Bruni, Amalia ^c   Franceschi, Claudio ^d   De Benedictis, Giovanna ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

^b INRCA   (Italy)

^c ASL   (Italy)

^d UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA; PRIMER DNA;

AGE; AGED; ARTICLE; CONTROLLED STUDY; DENATURING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; FEMALE; GENETIC REGULATION; GENOME; HETEROPLASMY; HUMAN; LEUKOCYTE; MALE; PARENT; PHENOTYPE; POLYMERASE CHAIN REACTION; PROGENY; SEQUENCE ANALYSIS; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MUTATION; NUCLEOTIDE SEQUENCE; SENSITIVITY AND SPECIFICITY; ULTRASTRUCTURE;

AGED; AGED, 80 AND OVER; BASE SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA PRIMERS; DNA, MITOCHONDRIAL; FEMALE; HUMANS; LEUKOCYTES; MALE; MUTATION; POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY;

EID: 35248861556     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-8-293     Document Type: Article

References (28)

1. DiMauro S Schon EA Mitochondrial respiratory-chain diseases N Engl J Med 2003, 348(26):2656-2668. 10.1056/NEJMra022567 12826641
2. DiMauro S Davidzon G Mitochondrial DNA and disease Ann Med 2005, 37:222-232. 10.1080/07853890510007368 16019721
3. Linnane AW Marzuki S Ozawa T Tanaka M Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases Lancet 1989, 1:642-645. 10.1016/S0140-6736(89)92145-4 2564461
4. Wallace DC A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine Annu Rev Genet 2005, 39:359-407. 10.1146/annurev.genet.39.110304.095751 16285865
5. Zhang J Asin-Cayuela J Fish J Michikawa Y Bonafè M Olivieri F Passarino G De Benedictis G Franceschi C Attardi G Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes Proc Natl Acad Sci USA 2003, 100:1116-1121. 298736 12538859 10.1073/pnas.242719399
6. Niemi AK Moilanen JS Tanaka M Hervonen A Hurme M Lehtimaki T Arai Y Hirose N Majamaa K A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects Eur J Hum Genet 2005, 13:166-170. 10.1038/sj.ejhg.5201308 15483642
7. Cournil A Kirkwood TB If you would live long, choose your parents well Trends Genet 2001, 17:233-235. 10.1016/S0168-9525(01)02306-X 11335017
8. Hjelmborg JV Iachine I Skytthe A Vaupel JW McGue M Koskenvuo M Kaprio J Pedersen NL Christensen K Genetic influence on human lifespan and longevity Hum Genet 2006, 119:312-321. 10.1007/s00439-006-0144-y 16463022
9. Chomyn A Attardi G MtDNA mutations in aging and apoptosis Biochem Biophys Res Commun 2003, 304:519-529. 10.1016/S0006-291X(03)00625-9 12729587
10. Shigenaga MK Agen TM Ames BN Oxidative damages and mitochondria decay in aging Proc Natl Acad Sci USA 1994, 91:10771-10778. 45108 7971961 10.1073/ pnas.91.23.10771
11. Atzmon G Rincon M Schechter CB Shuldiner AR Lipton RB Bergman A Barzilai N Lipoprotein genotype and conserved pathway for exceptional longevity in humans PLOS Biology 2006, 4(4):e113. 10.1371/journal.pbio.0040113 16602826 1413567
12. van Den Bosch BJ de Coo RF Scholte HR Nijland JG van Den Bogaard R de Visser M de Die-Smulders CE Smeets HJ Mutation analysis of the entire mitochondrial genome using denaturing high performance liquid chromatography Nucleic Acids Res 2000, 28(20):E89. 10.1093/nar/28.20.e89 11024191 110805
13. Liu MR Pan KF Li ZF Wang Y Deng DJ Zhang L Lu YY Rapid screening mitochondrial DNA mutation by using denaturing high-performance liquid chromatography World J Gastroenterol 2002, 8:426-430. 12046063
14. Bayat A Walter J Lamb H Marino M Ferguson MW Ollier WE Mitochondrial mutation detection using enhanced multiplex denaturing high-performance liquid chromatography Int J Immunogenet 2005, 32:199-205. 10.1111/ j.1744-313X.2005.00508.x 15932626
15. Biggin A Henke R Bennetts B Thorburn DR Christodoulou J Mutation screening of the mitochondrial genome using denaturing high-performance liquid chromatography Mol Genet Metab 2005, 84:61-74. 10.1016/ j.ymgme.2004.09.011 15639196
16. Meierhofer D Mayr JA Ebner S Sperl W Kofler B Rapid screening of the entire mitochondrial DNA for low-level heteroplasmic mutations Mitochondrion 2005, 5:282-296. 10.1016/j.mito.2005.06.001 16050991
17. Parr RL Maki J Reguly B Dakubo GD Aguirre A Wittock R Robinson K Jakupciak JP Thayer RE The pseudo-mitochondrial genome influences mistakes in heteroplasmy interpretation BMC Genomics 2006, 7:185-197. 1538596 16859552 10.1186/1471-2164-7-185
18. Michikawa Y Mazzucchelli F Bresolin N Scarlato G Attardi G Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication Science 1999, 286:774-779. 10.1126/ science.286.5440.774 10531063
19. Fish J Raule N Attardi G Discovery of a major D-loop replication origin reveals two modes of human mtDNA synthesis Science 2004, 306:2098-2101. 10.1126/science.1102077 15604407
20. Gudmundsson H Gudbjartsson DF Frigge M Gulcher JR Stefansson K Inheritance of human longevity in Iceland Eur J Hum Genet 2000, 8:743-749. 10.1038/sj.ejhg.5200527 11039573
21. Atzmon G Rincon M Rabizadeh P Barzilai N Biological evidence for inheritance of exceptional longevity Mech Ageing Dev 2005, 126:341-345. 10.1016/j.mad.2004.08.026 15621216
22. Sato A Nakada K Hayashi JI Mitochondrial dynamics and aging: mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA Biochim Biophys Acta 2006, 1763:473-481. 10.1016/j.bbamcr.2006.03.001 16624428
23. Ono T Isobe K Nakada K Hayashi JI Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria Nat Genet 2001, 28:272-275. 10.1038/90116 11431699
24. Perls T Kunkel LM Puca AA The genetics of exceptional human longevity J Am Geriatr Soc 2002, 50:359-368. 10.1046/j.1532-5415.2002.49283.x 12028221
25. The ECHA Project http://biologia.unical.it/echa
26. DHPLC Melt Program http://insertion.stanford.edu/melt.html
27. Torroni A Huoponen K Francalacci P Petrozzi M Morelli L Scozzari R Obinu D Savontaus ML Wallace DC Classification of European mtDNAs from an analysis of three European populations Genetics 1996, 144:1835-1850. 1207732 8978068
28. MITOMAP: A Human Mitochondrial Genome Database http://www.mitomap.org