메뉴 건너뛰기




Volumn 301, Issue 4, 2011, Pages

Caloric restriction: Powerful protection for the aging heart and vasculature

Author keywords

Arterial stiffness; Cardiovascular aging; Cardiovascular disease; Inflammation; Oxidative stress

Indexed keywords

AGING; APOPTOSIS; ARTERIAL STIFFNESS; ATHEROSCLEROSIS; CALORIC RESTRICTION; CARDIOVASCULAR RISK; ENDOTHELIAL DYSFUNCTION; HAPLORHINI; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE FIBROSIS; HEART PROTECTION; HUMAN; INFLAMMATION; LIFESPAN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; VASCULARIZATION;

EID: 80053235435     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00685.2011     Document Type: Review
Times cited : (150)

References (218)
  • 2
    • 79959523055 scopus 로고    scopus 로고
    • Effects of calorie restriction on cardioprotection and cardiovascular health
    • Ahmet I, Tae HJ, de Cabo R, Lakatta EG, Talan MI. Effects of calorie restriction on cardioprotection and cardiovascular health. J Mol Cell Cardiol 51: 263-271, 2011.
    • (2011) J Mol Cell Cardiol , vol.51 , pp. 263-271
    • Ahmet, I.1    Tae, H.J.2    de Cabo, R.3    Lakatta, E.G.4    Talan, M.I.5
  • 3
    • 33645978121 scopus 로고    scopus 로고
    • Metabolic syndrome-a new worldwide definition. A consensus statement from the International Diabetes Federation
    • Alberti KG, Zimmet P, Shaw J. Metabolic syndrome-a new worldwide definition. A consensus statement from the International Diabetes Federation. Diabet Med 23: 469-480, 2006.
    • (2006) Diabet Med , vol.23 , pp. 469-480
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 4
    • 0043246655 scopus 로고    scopus 로고
    • The legacy of Biosphere 2 for the study of biospherics and closed ecological systems
    • Allen JP, Nelson M, Alling A. The legacy of Biosphere 2 for the study of biospherics and closed ecological systems. Adv Space Res 31: 1629-1639, 2003.
    • (2003) Adv Space Res , vol.31 , pp. 1629-1639
    • Allen, J.P.1    Nelson, M.2    Alling, A.3
  • 6
    • 0842281506 scopus 로고    scopus 로고
    • Influence of age, gender, body mass index, and functional capacity on heart rate variability in a cohort of subjects without heart disease
    • Antelmi I, de Paula RS, Shinzato AR, Peres CA, Mansur AJ, Grupi CJ. Influence of age, gender, body mass index, and functional capacity on heart rate variability in a cohort of subjects without heart disease. Am J Cardiol 93: 381-385, 2004.
    • (2004) Am J Cardiol , vol.93 , pp. 381-385
    • Antelmi, I.1    de Paula, R.S.2    Shinzato, A.R.3    Peres, C.A.4    Mansur, A.J.5    Grupi, C.J.6
  • 8
    • 0029005206 scopus 로고
    • Genetic and environmental factors in the function and structure of the arterial wall
    • Avolio A. Genetic and environmental factors in the function and structure of the arterial wall. Hypertension 26: 34-37, 1995.
    • (1995) Hypertension , vol.26 , pp. 34-37
    • Avolio, A.1
  • 9
    • 0020578305 scopus 로고
    • Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community
    • Avolio AP, Chen SG, Wang RP, Zhang CL, Li MF, O'Rourke MF. Effects of aging on changing arterial compliance and left ventricular load in a northern Chinese urban community. Circulation 68: 50-58, 1983.
    • (1983) Circulation , vol.68 , pp. 50-58
    • Avolio, A.P.1    Chen, S.G.2    Wang, R.P.3    Zhang, C.L.4    Li, M.F.5    O'Rourke, M.F.6
  • 10
    • 0021989647 scopus 로고
    • Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: Comparison between urban and rural communities in China
    • Avolio AP, Deng FQ, Li WQ, Luo YF, Huang ZD, Xing LF, O'Rourke MF. Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: comparison between urban and rural communities in China. Circulation 71: 202-210, 1985.
    • (1985) Circulation , vol.71 , pp. 202-210
    • Avolio, A.P.1    Deng, F.Q.2    Li, W.Q.3    Luo, Y.F.4    Huang, Z.D.5    Xing, L.F.6    O'Rourke, M.F.7
  • 11
    • 0031908571 scopus 로고    scopus 로고
    • Lipoprotein profile and high-density lipoproteins: Subfractions distribution in centenarians
    • Barbagallo CM, Averna MR, Frada G, Noto D, Cavera G, Notarbartolo A. Lipoprotein profile and high-density lipoproteins: subfractions distribution in centenarians. Gerontology 44: 106-110, 1998.
    • (1998) Gerontology , vol.44 , pp. 106-110
    • Barbagallo, C.M.1    Averna, M.R.2    Frada, G.3    Noto, D.4    Cavera, G.5    Notarbartolo, A.6
  • 12
    • 4544322045 scopus 로고    scopus 로고
    • Free radicals and aging
    • Barja G. Free radicals and aging. Trends Neurosci 27: 595-600, 2004.
    • (2004) Trends Neurosci , vol.27 , pp. 595-600
    • Barja, G.1
  • 13
    • 0031880436 scopus 로고    scopus 로고
    • Isolated postchallenge hyperglycemia and the risk of fatal cardiovascular disease in older women and men. The Rancho Bernardo Study
    • Barrett-Connor E, Ferrara A. Isolated postchallenge hyperglycemia and the risk of fatal cardiovascular disease in older women and men. The Rancho Bernardo Study. Diabetes Care 21: 1236-1239, 1998.
    • (1998) Diabetes Care , vol.21 , pp. 1236-1239
    • Barrett-Connor, E.1    Ferrara, A.2
  • 14
    • 0000567961 scopus 로고    scopus 로고
    • Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat
    • Barzilai N, Banerjee S, Hawkins M, Chen W, Rossetti L. Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat. J Clin Invest 101: 1353-1361, 1998.
    • (1998) J Clin Invest , vol.101 , pp. 1353-1361
    • Barzilai, N.1    Banerjee, S.2    Hawkins, M.3    Chen, W.4    Rossetti, L.5
  • 15
    • 73949112047 scopus 로고    scopus 로고
    • Aging blunts the dynamics of vasodilation in isolated skeletal muscle resistance vessels
    • Behnke BJ, Delp MD. Aging blunts the dynamics of vasodilation in isolated skeletal muscle resistance vessels. J Appl Physiol 108: 14-20, 2010.
    • (2010) J Appl Physiol , vol.108 , pp. 14-20
    • Behnke, B.J.1    Delp, M.D.2
  • 17
    • 0033755958 scopus 로고    scopus 로고
    • Endothelial cell activation, injury, damage and dysfunction: Separate entities or mutual terms?
    • Blann AD. Endothelial cell activation, injury, damage and dysfunction: separate entities or mutual terms? Blood Coagul Fibrinolysis 11: 623-630, 2000.
    • (2000) Blood Coagul Fibrinolysis , vol.11 , pp. 623-630
    • Blann, A.D.1
  • 19
    • 0026482265 scopus 로고
    • Advanced glycosylation: Chemistry, biology, and implications for diabetes and aging
    • Bucala R, Cerami A. Advanced glycosylation: chemistry, biology, and implications for diabetes and aging. Adv Pharmacol 23: 1-34, 1992.
    • (1992) Adv Pharmacol , vol.23 , pp. 1-34
    • Bucala, R.1    Cerami, A.2
  • 21
    • 0030690288 scopus 로고    scopus 로고
    • Biogenic 4-hydroxy-2-nonenal activates transcription factor AP-1 but not NF-kappa B in cells of the macrophage lineage
    • Camandola S, Scavazza A, Leonarduzzi G, Biasi F, Chiarpotto E, Azzi A, Poli G. Biogenic 4-hydroxy-2-nonenal activates transcription factor AP-1 but not NF-kappa B in cells of the macrophage lineage. Biofactors 6: 173-179, 1997.
    • (1997) Biofactors , vol.6 , pp. 173-179
    • Camandola, S.1    Scavazza, A.2    Leonarduzzi, G.3    Biasi, F.4    Chiarpotto, E.5    Azzi, A.6    Poli, G.7
  • 22
    • 0017187453 scopus 로고
    • The affinity of low density lipoproteins for an arterial macromolecular complex. A study in ischemic heart disease and controls
    • Camejo G, Waich S, Quintero G, Berrizbeitia ML, Lalaguna F. The affinity of low density lipoproteins for an arterial macromolecular complex. A study in ischemic heart disease and controls. Atherosclerosis 24: 341-354, 1976.
    • (1976) Atherosclerosis , vol.24 , pp. 341-354
    • Camejo, G.1    Waich, S.2    Quintero, G.3    Berrizbeitia, M.L.4    Lalaguna, F.5
  • 23
    • 77953239921 scopus 로고    scopus 로고
    • Long-term effects of calorie restriction on serum sex-hormone concentrations in men
    • Cangemi R, Friedmann AJ, Holloszy JO, Fontana L. Long-term effects of calorie restriction on serum sex-hormone concentrations in men. Aging Cell 9: 236-242, 2010.
    • (2010) Aging Cell , vol.9 , pp. 236-242
    • Cangemi, R.1    Friedmann, A.J.2    Holloszy, J.O.3    Fontana, L.4
  • 28
    • 7444244279 scopus 로고    scopus 로고
    • Caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca fascicularis): Metabolic, physiologic, and atherosclerotic measures from a 4-year intervention trial
    • Cefalu WT, Wang ZQ, Bell-Farrow AD, Collins J, Morgan T, Wagner JD. Caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca fascicularis): metabolic, physiologic, and atherosclerotic measures from a 4-year intervention trial. J Gerontol A Biol Sci Med Sci 59: 1007-1014, 2004.
    • (2004) J Gerontol a Biol Sci Med Sci , vol.59 , pp. 1007-1014
    • Cefalu, W.T.1    Wang, Z.Q.2    Bell-Farrow, A.D.3    Collins, J.4    Morgan, T.5    Wagner, J.D.6
  • 30
    • 0022339852 scopus 로고
    • Hypothesis. Glucose as a mediator of aging
    • Cerami A. Hypothesis. Glucose as a mediator of aging. J Am Geriatr Soc 33: 626-634, 1985.
    • (1985) J Am Geriatr Soc , vol.33 , pp. 626-634
    • Cerami, A.1
  • 31
    • 78649752866 scopus 로고    scopus 로고
    • Commonly adopted caloric restriction protocols often involve malnutrition
    • Cerqueira FM, Kowaltowski AJ. Commonly adopted caloric restriction protocols often involve malnutrition. Ageing Res Rev 9: 424-430, 2010.
    • (2010) Ageing Res Rev , vol.9 , pp. 424-430
    • Cerqueira, F.M.1    Kowaltowski, A.J.2
  • 32
    • 0037233874 scopus 로고    scopus 로고
    • Cardiovascular physiology-changes with aging
    • Cheitlin MD. Cardiovascular physiology-changes with aging. Am J Geriatr Cardiol 12: 9-13, 2003.
    • (2003) Am J Geriatr Cardiol , vol.12 , pp. 9-13
    • Cheitlin, M.D.1
  • 37
    • 0031824031 scopus 로고    scopus 로고
    • The effect of dietary restriction on body composition in adult male and female rhesus macaques
    • Colman RJ, Roecker EB, Ramsey JJ, Kemnitz JW. The effect of dietary restriction on body composition in adult male and female rhesus macaques. Aging (Milano) 10: 83-92, 1998.
    • (1998) Aging (Milano) , vol.10 , pp. 83-92
    • Colman, R.J.1    Roecker, E.B.2    Ramsey, J.J.3    Kemnitz, J.W.4
  • 38
    • 0035348301 scopus 로고    scopus 로고
    • Effect of aging and hypertension on beta-myosin heavy chain in heart of spontaneously hypertensive rats
    • Compagno V, Di L, I, Cestelli A, Donatelli M. Effect of aging and hypertension on beta-myosin heavy chain in heart of spontaneously hypertensive rats. Int J Mol Med 7: 507-508, 2001.
    • (2001) Int J Mol Med , vol.7 , pp. 507-508
    • Compagno, V.1    Di I., L.2    Cestelli, A.3    Donatelli, M.4
  • 39
    • 0031054463 scopus 로고    scopus 로고
    • Nitric oxide synthase: Role in the genesis of vascular disease
    • Cooke JP, Dzau VJ. Nitric oxide synthase: role in the genesis of vascular disease. Annu Rev Med 48: 489-509, 1997.
    • (1997) Annu Rev Med , vol.48 , pp. 489-509
    • Cooke, J.P.1    Dzau, V.J.2
  • 40
    • 0025996632 scopus 로고
    • Myocardial fibrosis in aging germ-free and conventional Lobund-Wistar rats: The protective effect of diet restriction
    • Cornwell GG III, Thomas BP, Snyder DL. Myocardial fibrosis in aging germ-free and conventional Lobund-Wistar rats: the protective effect of diet restriction. J Gerontol 46: B167-B170, 1991.
    • (1991) J Gerontol , vol.46
    • Cornwell III., G.G.1    Thomas, B.P.2    Snyder, D.L.3
  • 41
    • 0032902850 scopus 로고    scopus 로고
    • The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 124 years
    • Coutinho M, Gerstein HC, Wang Y, Yusuf S. The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 124 years. Diabetes Care 22: 233-240, 1999.
    • (1999) Diabetes Care , vol.22 , pp. 233-240
    • Coutinho, M.1    Gerstein, H.C.2    Wang, Y.3    Yusuf, S.4
  • 45
    • 0038718728 scopus 로고    scopus 로고
    • Aginginduced proinflammatory shift in cytokine expression profile in coronary arteries
    • Csiszar A, Ungvari Z, Koller A, Edwards JG, Kaley G. Aginginduced proinflammatory shift in cytokine expression profile in coronary arteries. FASEB J 17: 1183-1185, 2003.
    • (2003) FASEB J , vol.17 , pp. 1183-1185
    • Csiszar, A.1    Ungvari, Z.2    Koller, A.3    Edwards, J.G.4    Kaley, G.5
  • 46
    • 1842509760 scopus 로고    scopus 로고
    • Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging
    • Csiszar A, Ungvari Z, Koller A, Edwards JG, Kaley G. Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging. Physiol Genomics 17: 21-30, 2004.
    • (2004) Physiol Genomics , vol.17 , pp. 21-30
    • Csiszar, A.1    Ungvari, Z.2    Koller, A.3    Edwards, J.G.4    Kaley, G.5
  • 47
    • 0022515518 scopus 로고
    • Association of levels of lipoprotein Lp(a), plasma lipids, and other lipoproteins with coronary artery disease documented by angiography
    • Dahlen GH, Guyton JR, Attar M, Farmer JA, Kautz JA, Gotto AM Jr. Association of levels of lipoprotein Lp(a), plasma lipids, and other lipoproteins with coronary artery disease documented by angiography. Circulation 74: 758-765, 1986.
    • (1986) Circulation , vol.74 , pp. 758-765
    • Dahlen, G.H.1    Guyton, J.R.2    Attar, M.3    Farmer, J.A.4    Kautz, J.A.5    Gotto Jr., A.M.6
  • 50
    • 0029670546 scopus 로고    scopus 로고
    • Beta-adrenoceptor function changes with age of subject in myocytes from non-failing human ventricle
    • Davies CH, Ferrara N, Harding SE. Beta-adrenoceptor function changes with age of subject in myocytes from non-failing human ventricle. Cardiovasc Res 31: 152-156, 1996.
    • (1996) Cardiovasc Res , vol.31 , pp. 152-156
    • Davies, C.H.1    Ferrara, N.2    Harding, S.E.3
  • 51
    • 75749125702 scopus 로고    scopus 로고
    • Impact of 6-month caloric restriction on autonomic nervous system activity in healthy, overweight, individuals
    • de Jonge L, Moreira EA, Martin CK, Ravussin E. Impact of 6-month caloric restriction on autonomic nervous system activity in healthy, overweight, individuals. Obesity (Silver Spring) 18: 414-416, 2010.
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 414-416
    • de Jonge, L.1    Moreira, E.A.2    Martin, C.K.3    Ravussin, E.4
  • 52
    • 33645987888 scopus 로고    scopus 로고
    • Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restriction
    • Dhahbi JM, Tsuchiya T, Kim HJ, Mote PL, Spindler SR. Gene expression and physiologic responses of the heart to the initiation and withdrawal of caloric restriction. J Gerontol A Biol Sci Med Sci 61: 218-231, 2006.
    • (2006) J Gerontol a Biol Sci Med Sci , vol.61 , pp. 218-231
    • Dhahbi, J.M.1    Tsuchiya, T.2    Kim, H.J.3    Mote, P.L.4    Spindler, S.R.5
  • 54
    • 34250216014 scopus 로고    scopus 로고
    • Direct evidence of endothelial oxidative stress with aging in humans: Relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB
    • Donato AJ, Eskurza I, Silver AE, Levy AS, Pierce GL, Gates PE, Seals DR. Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB. Circ Res 100: 1659-1666, 2007.
    • (2007) Circ Res , vol.100 , pp. 1659-1666
    • Donato, A.J.1    Eskurza, I.2    Silver, A.E.3    Levy, A.S.4    Pierce, G.L.5    Gates, P.E.6    Seals, D.R.7
  • 56
    • 0028331388 scopus 로고
    • Calcification of the human thoracic aorta during aging
    • Elliott RJ, McGrath LT. Calcification of the human thoracic aorta during aging. Calcif Tissue Int 54: 268-273, 1994.
    • (1994) Calcif Tissue Int , vol.54 , pp. 268-273
    • Elliott, R.J.1    McGrath, L.T.2
  • 57
    • 34447303786 scopus 로고    scopus 로고
    • Effects of life-long caloric restriction and voluntary exercise on age-related changes in levels of catecholamine biosynthetic enzymes and angiotensin II receptors in the rat adrenal medulla and hypothalamus
    • Erdos B, Broxson CS, Landa T, Scarpace PJ, Leeuwenburgh C, Zhang Y, Tumer N. Effects of life-long caloric restriction and voluntary exercise on age-related changes in levels of catecholamine biosynthetic enzymes and angiotensin II receptors in the rat adrenal medulla and hypothalamus. Exp Gerontol 42: 745-752, 2007.
    • (2007) Exp Gerontol , vol.42 , pp. 745-752
    • Erdos, B.1    Broxson, C.S.2    Landa, T.3    Scarpace, P.J.4    Leeuwenburgh, C.5    Zhang, Y.6    Tumer, N.7
  • 61
    • 33847764645 scopus 로고    scopus 로고
    • Adiposity and calorie restriction
    • Fontana L, Klein S. Aging, adiposity and calorie restriction. JAMA 297: 986-994, 2007.
    • (2007) JAMA , vol.297 , pp. 986-994
    • Fontana, L.1    Aging Klein, S.2
  • 62
    • 77949424755 scopus 로고    scopus 로고
    • Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production
    • Fontana L, Klein S, Holloszy JO. Effects of long-term calorie restriction and endurance exercise on glucose tolerance, insulin action, and adipokine production. Age (Dordr) 32: 97-108, 2010.
    • (2010) Age (Dordr) , vol.32 , pp. 97-108
    • Fontana, L.1    Klein, S.2    Holloszy, J.O.3
  • 63
    • 33747645526 scopus 로고    scopus 로고
    • Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones
    • Fontana L, Klein S, Holloszy JO, Premachandra BN. Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones. J Clin Endocrinol Metab 91: 3232-3235, 2006.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3232-3235
    • Fontana, L.1    Klein, S.2    Holloszy, J.O.3    Premachandra, B.N.4
  • 64
    • 2342647592 scopus 로고    scopus 로고
    • Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
    • Fontana L, Meyer TE, Klein S, Holloszy JO. Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc Natl Acad Sci USA 101: 6659-6663, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6659-6663
    • Fontana, L.1    Meyer, T.E.2    Klein, S.3    Holloszy, J.O.4
  • 65
    • 77951176737 scopus 로고    scopus 로고
    • Extending healthy life span-from yeast to humans
    • Fontana L, Partridge L, Longo VD. Extending healthy life span-from yeast to humans. Science 328: 321-326, 2010.
    • (2010) Science , vol.328 , pp. 321-326
    • Fontana, L.1    Partridge, L.2    Longo, V.D.3
  • 67
    • 52449087974 scopus 로고    scopus 로고
    • Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans
    • Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO. Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell 7: 681-687, 2008.
    • (2008) Aging Cell , vol.7 , pp. 681-687
    • Fontana, L.1    Weiss, E.P.2    Villareal, D.T.3    Klein, S.4    Holloszy, J.O.5
  • 69
    • 49649083150 scopus 로고    scopus 로고
    • Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the Framingham heart study
    • Fox CS, Pencina MJ, Wilson PW, Paynter NP, Vasan RS, D'Agostino RB Sr. Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the Framingham heart study. Diabetes Care 31: 1582-1584, 2008.
    • (2008) Diabetes Care , vol.31 , pp. 1582-1584
    • Fox, C.S.1    Pencina, M.J.2    Wilson, P.W.3    Paynter, N.P.4    Vasan, R.S.5    D'Agostino Sr., R.B.6
  • 72
    • 73349112920 scopus 로고    scopus 로고
    • Etanercept improves inflammation-associated arterial stiffness in rheumatoid arthritis
    • Galarraga B, Khan F, Kumar P, Pullar T, Belch JJ. Etanercept improves inflammation-associated arterial stiffness in rheumatoid arthritis. Rheumatology (Oxford) 48: 1418-1423, 2009.
    • (2009) Rheumatology (Oxford) , vol.48 , pp. 1418-1423
    • Galarraga, B.1    Khan, F.2    Kumar, P.3    Pullar, T.4    Belch, J.J.5
  • 73
    • 0024553336 scopus 로고
    • Nitric oxide-generating vasodilators and 8-bromocyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells
    • Garg UC, Hassid A. Nitric oxide-generating vasodilators and 8-bromocyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 83: 1774-1777, 1989.
    • (1989) J Clin Invest , vol.83 , pp. 1774-1777
    • Garg, U.C.1    Hassid, A.2
  • 74
    • 0030006173 scopus 로고    scopus 로고
    • Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans
    • Gerhard M, Roddy MA, Creager SJ, Creager MA. Aging progressively impairs endothelium-dependent vasodilation in forearm resistance vessels of humans. Hypertension 27: 849-853, 1996.
    • (1996) Hypertension , vol.27 , pp. 849-853
    • Gerhard, M.1    Roddy, M.A.2    Creager, S.J.3    Creager, M.A.4
  • 78
    • 0035403165 scopus 로고    scopus 로고
    • Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart
    • Gredilla R, Sanz A, Lopez-Torres M, Barja G. Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart. FASEB J 15: 1589-1591, 2001.
    • (2001) FASEB J , vol.15 , pp. 1589-1591
    • Gredilla, R.1    Sanz, A.2    Lopez-Torres, M.3    Barja, G.4
  • 81
    • 0027394701 scopus 로고
    • Food restriction-induced transformations in cardiac functional and biochemical properties in rats
    • Haddad F, Bodell PW, McCue SA, Herrick RE, Baldwin KM. Food restriction-induced transformations in cardiac functional and biochemical properties in rats. J Appl Physiol 74: 606-612, 1993.
    • (1993) J Appl Physiol , vol.74 , pp. 606-612
    • Haddad, F.1    Bodell, P.W.2    McCue, S.A.3    Herrick, R.E.4    Baldwin, K.M.5
  • 82
    • 0038690424 scopus 로고    scopus 로고
    • Trends in prevalence, awareness, treatment, and control of hypertension in the United States, 1988-2000
    • Hajjar I, Kotchen TA. Trends in prevalence, awareness, treatment, and control of hypertension in the United States, 1988-2000. JAMA 290: 199-206, 2003.
    • (2003) JAMA , vol.290 , pp. 199-206
    • Hajjar, I.1    Kotchen, T.A.2
  • 83
    • 0034255365 scopus 로고    scopus 로고
    • The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation
    • Hajra L, Evans AI, Chen M, Hyduk SJ, Collins T, Cybulsky MI. The NF-kappa B signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation. Proc Natl Acad Sci USA 97: 9052-9057, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9052-9057
    • Hajra, L.1    Evans, A.I.2    Chen, M.3    Hyduk, S.J.4    Collins, T.5    Cybulsky, M.I.6
  • 84
    • 17644412023 scopus 로고    scopus 로고
    • Inflammation atherosclerosis, and coronary artery disease
    • Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 352: 1685-1695, 2005.
    • (2005) N Engl J Med , vol.352 , pp. 1685-1695
    • Hansson, G.K.1
  • 87
    • 0026452373 scopus 로고
    • Long-term calorie restriction enhances baroreflex responsiveness in Fischer 344 rats
    • Herlihy JT, Stacy C, Bertrand HA. Long-term calorie restriction enhances baroreflex responsiveness in Fischer 344 rats. Am J Physiol Heart Circ Physiol 263: H1021-H1025, 1992.
    • (1992) Am J Physiol Heart Circ Physiol , vol.263
    • Herlihy, J.T.1    Stacy, C.2    Bertrand, H.A.3
  • 88
    • 0021928691 scopus 로고
    • Effects of aging on catecholamine metabolism
    • Hoeldtke RD, Cilmi KM. Effects of aging on catecholamine metabolism. J Clin Endocrinol Metab 60: 479-484, 1985.
    • (1985) J Clin Endocrinol Metab , vol.60 , pp. 479-484
    • Hoeldtke, R.D.1    Cilmi, K.M.2
  • 89
    • 50449096909 scopus 로고    scopus 로고
    • Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans
    • Hofer T, Fontana L, Anton SD, Weiss EP, Villareal D, Malayappan B, Leeuwenburgh C. Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans. Rejuvenation Res 11: 793-799, 2008.
    • (2008) Rejuvenation Res , vol.11 , pp. 793-799
    • Hofer, T.1    Fontana, L.2    Anton, S.D.3    Weiss, E.P.4    Villareal, D.5    Malayappan, B.6    Leeuwenburgh, C.7
  • 91
    • 0036371485 scopus 로고    scopus 로고
    • Roles of Nrf2 in activation of antioxidant enzyme genes via antioxidant responsive elements
    • Ishii T, Itoh K, Yamamoto M. Roles of Nrf2 in activation of antioxidant enzyme genes via antioxidant responsive elements. Methods Enzymol 348: 182-190, 2002.
    • (2002) Methods Enzymol , vol.348 , pp. 182-190
    • Ishii, T.1    Itoh, K.2    Yamamoto, M.3
  • 94
    • 67349221470 scopus 로고    scopus 로고
    • Aortic inflammation, as assessed by hybrid FDG-PET/CT imaging, is associated with enhanced aortic stiffness in addition to concurrent calcification
    • Joly L, Djaballah W, Koehl G, Mandry D, Dolivet G, Marie PY, Benetos A. Aortic inflammation, as assessed by hybrid FDG-PET/CT imaging, is associated with enhanced aortic stiffness in addition to concurrent calcification. Eur J Nucl Med Mol Imaging 36: 979-985, 2009.
    • (2009) Eur J Nucl Med Mol Imaging , vol.36 , pp. 979-985
    • Joly, L.1    Djaballah, W.2    Koehl, G.3    Mandry, D.4    Dolivet, G.5    Marie, P.Y.6    Benetos, A.7
  • 95
    • 33646012604 scopus 로고    scopus 로고
    • Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6
    • Kalani R, Judge S, Carter C, Pahor M, Leeuwenburgh C. Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6. J Gerontol A Biol Sci Med Sci 61: 211-217, 2006.
    • (2006) J Gerontol a Biol Sci Med Sci , vol.61 , pp. 211-217
    • Kalani, R.1    Judge, S.2    Carter, C.3    Pahor, M.4    Leeuwenburgh, C.5
  • 96
    • 0024242627 scopus 로고
    • Effect of diet restriction on glucose metabolism and insulin responsiveness in aging rats
    • Kalant N, Stewart J, Kaplan R. Effect of diet restriction on glucose metabolism and insulin responsiveness in aging rats. Mech Ageing Dev 46: 89-104, 1988.
    • (1988) Mech Ageing Dev , vol.46 , pp. 89-104
    • Kalant, N.1    Stewart, J.2    Kaplan, R.3
  • 97
    • 69249106918 scopus 로고    scopus 로고
    • Aging impairs flow-induced dilation in coronary arterioles: Role of NO and H2O2
    • Kang LS, Reyes RA, Muller-Delp JM. Aging impairs flow-induced dilation in coronary arterioles: role of NO and H2O2. Am J Physiol Heart Circ Physiol 297: H1087-H1095, 2009.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297
    • Kang, L.S.1    Reyes, R.A.2    Muller-Delp, J.M.3
  • 98
    • 0028079625 scopus 로고
    • Reduced adipose tissue lipoprotein lipase responses, postprandial lipemia, and low high-density lipoprotein-2 subspecies levels in older athletes with silent myocardial ischemia
    • Katzel LI, Busby-Whitehead MJ, Rogus EM, Krauss RM, Goldberg AP. Reduced adipose tissue lipoprotein lipase responses, postprandial lipemia, and low high-density lipoprotein-2 subspecies levels in older athletes with silent myocardial ischemia. Metabolism 43: 190-198, 1994.
    • (1994) Metabolism , vol.43 , pp. 190-198
    • Katzel, L.I.1    Busby-Whitehead, M.J.2    Rogus, E.M.3    Krauss, R.M.4    Goldberg, A.P.5
  • 99
    • 0025169744 scopus 로고
    • Quantitative study of tyrosine hydroxylase mRNA in catecholaminergic neurons and adrenals during development and aging
    • Kedzierski W, Porter JC. Quantitative study of tyrosine hydroxylase mRNA in catecholaminergic neurons and adrenals during development and aging. Brain Res Mol Brain Res 7: 45-51, 1990.
    • (1990) Brain Res Mol Brain Res , vol.7 , pp. 45-51
    • Kedzierski, W.1    Porter, J.C.2
  • 100
    • 0034102231 scopus 로고    scopus 로고
    • The relative protective effects of moderate dietary restriction versus dietary modification on spontaneous cardiomyopathy in male Sprague-Dawley rats
    • Kemi M, Keenan KP, McCoy C, Hoe CM, Soper KA, Ballam GC, van Zwieten MJ. The relative protective effects of moderate dietary restriction versus dietary modification on spontaneous cardiomyopathy in male Sprague-Dawley rats. Toxicol Pathol 28: 285-296, 2000.
    • (2000) Toxicol Pathol , vol.28 , pp. 285-296
    • Kemi, M.1    Keenan, K.P.2    McCoy, C.3    Hoe, C.M.4    Soper, K.A.5    Ballam, G.C.6    van Zwieten, M.J.7
  • 102
    • 33745443018 scopus 로고    scopus 로고
    • Estimation of an age-specific reference interval for pulse wave velocity: A meta-analysis
    • Khoshdel AR, Thakkinstian A, Carney SL, Attia J. Estimation of an age-specific reference interval for pulse wave velocity: a meta-analysis. J Hypertens 24: 1231-1237, 2006.
    • (2006) J Hypertens , vol.24 , pp. 1231-1237
    • Khoshdel, A.R.1    Thakkinstian, A.2    Carney, S.L.3    Attia, J.4
  • 103
    • 0025943095 scopus 로고
    • Age-related alterations of Doppler left ventricular filling indexes in normal subjects are independent of left ventricular mass, heart rate, contractility and loading conditions
    • Kitzman DW, Sheikh KH, Beere PA, Philips JL, Higginbotham MB. Age-related alterations of Doppler left ventricular filling indexes in normal subjects are independent of left ventricular mass, heart rate, contractility and loading conditions. J Am Coll Cardiol 18: 1243-1250, 1991.
    • (1991) J Am Coll Cardiol , vol.18 , pp. 1243-1250
    • Kitzman, D.W.1    Sheikh, K.H.2    Beere, P.A.3    Philips, J.L.4    Higginbotham, M.B.5
  • 104
    • 0030802102 scopus 로고    scopus 로고
    • Effect of life-long food restriction on cardiac myosin composition
    • Klebanov S, Herlihy JT. Effect of life-long food restriction on cardiac myosin composition. J Gerontol A Biol Sci Med Sci 52: B184-B189, 1997.
    • (1997) J Gerontol a Biol Sci Med Sci , vol.52
    • Klebanov, S.1    Herlihy, J.T.2
  • 106
    • 33748052967 scopus 로고    scopus 로고
    • Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
    • Kobayashi M, Yamamoto M. Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species. Adv Enzyme Regul 46: 113-140, 2006.
    • (2006) Adv Enzyme Regul , vol.46 , pp. 113-140
    • Kobayashi, M.1    Yamamoto, M.2
  • 107
    • 0023197635 scopus 로고
    • Evaluation of diastolic function with Doppler echocardiography: The PDF formalism
    • Kovacs SJ Jr, Barzilai B, Perez JE. Evaluation of diastolic function with Doppler echocardiography: the PDF formalism. Am J Physiol Heart Circ Physiol 252: H178-H187, 1987.
    • (1987) Am J Physiol Heart Circ Physiol , vol.252
    • Kovacs Jr., S.J.1    Barzilai, B.2    Perez, J.E.3
  • 108
    • 0025731835 scopus 로고
    • Nitric oxide: An endogenous modulator of leukocyte adhesion
    • Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 88: 4651-4655, 1991.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4651-4655
    • Kubes, P.1    Suzuki, M.2    Granger, D.N.3
  • 110
    • 0023161153 scopus 로고
    • Cardiac muscle changes in senescence
    • Lakatta EG. Cardiac muscle changes in senescence. Annu Rev Physiol 49: 519-531, 1987.
    • (1987) Annu Rev Physiol , vol.49 , pp. 519-531
    • Lakatta, E.G.1
  • 111
    • 0027417262 scopus 로고
    • Cardiovascular regulatory mechanisms in advanced age
    • Lakatta EG. Cardiovascular regulatory mechanisms in advanced age. Physiol Rev 73: 413-467, 1993.
    • (1993) Physiol Rev , vol.73 , pp. 413-467
    • Lakatta, E.G.1
  • 112
    • 0032909057 scopus 로고    scopus 로고
    • Cardiovascular aging research: The next horizons
    • Lakatta EG. Cardiovascular aging research: the next horizons. J Am Geriatr Soc 47: 613-625, 1999.
    • (1999) J Am Geriatr Soc , vol.47 , pp. 613-625
    • Lakatta, E.G.1
  • 114
    • 0037422592 scopus 로고    scopus 로고
    • Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises: Part I: Aging arteries: A "set up" for vascular disease
    • Lakatta EG, Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease. Circulation 107: 139-146, 2003.
    • (2003) Circulation , vol.107 , pp. 139-146
    • Lakatta, E.G.1    Levy, D.2
  • 116
    • 3042970541 scopus 로고    scopus 로고
    • Calorie restriction in nonhuman primates: Implications for age-related disease risk
    • Lane MA, Black A, Ingram DK, Roth GS. Calorie restriction in nonhuman primates: implications for age-related disease risk. J Anti- Aging Med 1: 315-326, 1998.
    • (1998) J Anti- Aging Med , vol.1 , pp. 315-326
    • Lane, M.A.1    Black, A.2    Ingram, D.K.3    Roth, G.S.4
  • 117
  • 119
    • 0032934327 scopus 로고    scopus 로고
    • Modulation of cardiac mitochondrial membrane fluidity by age and calorie intake
    • Lee J, Yu BP, Herlihy JT. Modulation of cardiac mitochondrial membrane fluidity by age and calorie intake. Free Radic Biol Med 26: 260-265, 1999.
    • (1999) Free Radic Biol Med , vol.26 , pp. 260-265
    • Lee, J.1    Yu, B.P.2    Herlihy, J.T.3
  • 120
    • 0031260095 scopus 로고    scopus 로고
    • Caloric restriction attenuates dityrosine cross-linking of cardiac and skeletal muscle proteins in aging mice
    • Leeuwenburgh C, Wagner P, Holloszy JO, Sohal RS, Heinecke JW. Caloric restriction attenuates dityrosine cross-linking of cardiac and skeletal muscle proteins in aging mice. Arch Biochem Biophys 346: 74-80, 1997.
    • (1997) Arch Biochem Biophys , vol.346 , pp. 74-80
    • Leeuwenburgh, C.1    Wagner, P.2    Holloszy, J.O.3    Sohal, R.S.4    Heinecke, J.W.5
  • 122
    • 0030756676 scopus 로고    scopus 로고
    • The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor beta1 expression in the macrophage lineage: A link between oxidative injury and fibrosclerosis
    • Leonarduzzi G, Scavazza A, Biasi F, Chiarpotto E, Camandola S, Vogel S, Dargel R, Poli G. The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor beta1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis. FASEB J 11: 851-857, 1997.
    • (1997) FASEB J , vol.11 , pp. 851-857
    • Leonarduzzi, G.1    Scavazza, A.2    Biasi, F.3    Chiarpotto, E.4    Camandola, S.5    Vogel, S.6    Dargel, R.7    Poli, G.8
  • 123
    • 77953819197 scopus 로고    scopus 로고
    • Calorie restriction at increasing levels leads to augmented concentrations of corticosterone and decreasing concentrations of testosterone in rats
    • Levay EA, Tammer AH, Penman J, Kent S, Paolini AG. Calorie restriction at increasing levels leads to augmented concentrations of corticosterone and decreasing concentrations of testosterone in rats. Nutr Res 30: 366-373, 2010.
    • (2010) Nutr Res , vol.30 , pp. 366-373
    • Levay, E.A.1    Tammer, A.H.2    Penman, J.3    Kent, S.4    Paolini, A.G.5
  • 124
    • 0023879355 scopus 로고
    • Echocardiographically detected left ventricular hypertrophy: Prevalence and risk factors. The Framingham Heart Study
    • Levy D, Anderson KM, Savage DD, Kannel WB, Christiansen JC, Castelli WP. Echocardiographically detected left ventricular hypertrophy: prevalence and risk factors. The Framingham Heart Study. Ann Intern Med 108: 7-13, 1988.
    • (1988) Ann Intern Med , vol.108 , pp. 7-13
    • Levy, D.1    Anderson, K.M.2    Savage, D.D.3    Kannel, W.B.4    Christiansen, J.C.5    Castelli, W.P.6
  • 125
    • 33644872836 scopus 로고    scopus 로고
    • Inflammation and cardiovascular disease mechanisms
    • Libby P. Inflammation and cardiovascular disease mechanisms. Am J Clin Nutr 83: 456S-460S, 2006.
    • (2006) Am J Clin Nutr , vol.83
    • Libby, P.1
  • 128
    • 53449086884 scopus 로고    scopus 로고
    • Involvement of MAPKs, NF-kappaB and p300 co-activator in IL-1beta-induced cytosolic phospholipase A2 expression in canine tracheal smooth muscle cells
    • Luo SF, Lin CC, Chen HC, Lin WN, Lee IT, Lee CW, Hsiao LD, Yang CM. Involvement of MAPKs, NF-kappaB and p300 co-activator in IL-1beta-induced cytosolic phospholipase A2 expression in canine tracheal smooth muscle cells. Toxicol Appl Pharmacol 232: 396-407, 2008.
    • (2008) Toxicol Appl Pharmacol , vol.232 , pp. 396-407
    • Luo, S.F.1    Lin, C.C.2    Chen, H.C.3    Lin, W.N.4    Lee, I.T.5    Lee, C.W.6    Hsiao, L.D.7    Yang, C.M.8
  • 130
    • 33646227422 scopus 로고    scopus 로고
    • Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats
    • Mager DE, Wan R, Brown M, Cheng A, Wareski P, Abernethy DR, Mattson MP. Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats. FASEB J 20: 631-637, 2006.
    • (2006) FASEB J , vol.20 , pp. 631-637
    • Mager, D.E.1    Wan, R.2    Brown, M.3    Cheng, A.4    Wareski, P.5    Abernethy, D.R.6    Mattson, M.P.7
  • 131
    • 22744445281 scopus 로고    scopus 로고
    • Overview of caloric restriction and ageing
    • Masoro EJ. Overview of caloric restriction and ageing. Mech Ageing Dev 126: 913-922, 2005.
    • (2005) Mech Ageing Dev , vol.126 , pp. 913-922
    • Masoro, E.J.1
  • 134
    • 0031927190 scopus 로고    scopus 로고
    • Age-related deterioration in arterial structure and function in postmenopausal women: Impact of hormone replacement therapy
    • McGrath BP, Liang YL, Teede H, Shiel LM, Cameron JD, Dart A. Age-related deterioration in arterial structure and function in postmenopausal women: impact of hormone replacement therapy. Arterioscler Thromb Vasc Biol 18: 1149-1156, 1998.
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 1149-1156
    • McGrath, B.P.1    Liang, Y.L.2    Teede, H.3    Shiel, L.M.4    Cameron, J.D.5    Dart, A.6
  • 135
    • 3042608187 scopus 로고    scopus 로고
    • Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload
    • McMullen JR, Sherwood MC, Tarnavski O, Zhang L, Dorfman AL, Shioi T, Izumo S. Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. Circulation 109: 3050-3055, 2004.
    • (2004) Circulation , vol.109 , pp. 3050-3055
    • McMullen, J.R.1    Sherwood, M.C.2    Tarnavski, O.3    Zhang, L.4    Dorfman, A.L.5    Shioi, T.6    Izumo, S.7
  • 137
    • 79960142104 scopus 로고    scopus 로고
    • The effect of caloric restriction and glycemic load on measures of oxidative stress and antioxidants in humans: Results from the CALERIE Trial of Human Caloric Restriction
    • Meydani M, Das S, Band M, Epstein S, Roberts S. The effect of caloric restriction and glycemic load on measures of oxidative stress and antioxidants in humans: results from the CALERIE Trial of Human Caloric Restriction. J Nutr Health Aging 15: 456-460, 2011.
    • (2011) J Nutr Health Aging , vol.15 , pp. 456-460
    • Meydani, M.1    Das, S.2    Band, M.3    Epstein, S.4    Roberts, S.5
  • 141
    • 0037372412 scopus 로고    scopus 로고
    • Effect of weight loss on VLDL-triglyceride and apoB-100 kinetics in women with abdominal obesity
    • Mittendorfer B, Patterson BW, Klein S. Effect of weight loss on VLDL-triglyceride and apoB-100 kinetics in women with abdominal obesity. Am J Physiol Endocrinol Metab 284: E549-E556, 2003.
    • (2003) Am J Physiol Endocrinol Metab , vol.284
    • Mittendorfer, B.1    Patterson, B.W.2    Klein, S.3
  • 142
    • 43549105337 scopus 로고    scopus 로고
    • Impact of statin therapy on left ventricular function and carotid arterial stiffness in patients with hypercholesterolemia
    • Mizuguchi Y, Oishi Y, Miyoshi H, Iuchi A, Nagase N, Oki T. Impact of statin therapy on left ventricular function and carotid arterial stiffness in patients with hypercholesterolemia. Circ J 72: 538-544, 2008.
    • (2008) Circ J , vol.72 , pp. 538-544
    • Mizuguchi, Y.1    Oishi, Y.2    Miyoshi, H.3    Iuchi, A.4    Nagase, N.5    Oki, T.6
  • 144
    • 67649402187 scopus 로고    scopus 로고
    • The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress
    • Nguyen T, Nioi P, Pickett CB. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J Biol Chem 284: 13291-13295, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 13291-13295
    • Nguyen, T.1    Nioi, P.2    Pickett, C.B.3
  • 145
    • 2542461241 scopus 로고    scopus 로고
    • Optimal low-density lipoprotein is 50 to 70 mg/dl: Lower is better and physiologically normal
    • O'Keefe JH Jr, Cordain L, Harris WH, Moe RM, Vogel R. Optimal low-density lipoprotein is 50 to 70 mg/dl: lower is better and physiologically normal. J Am Coll Cardiol 43: 2142-2146, 2004.
    • (2004) J Am Coll Cardiol , vol.43 , pp. 2142-2146
    • O'Keefe Jr., J.H.1    Cordain, L.2    Harris, W.H.3    Moe, R.M.4    Vogel, R.5
  • 146
    • 0037052454 scopus 로고    scopus 로고
    • Broken limits to life expectancy
    • Oeppen J, Vaupel Demography JW. Broken limits to life expectancy. Science 296: 1029-1031, 2002.
    • (2002) Science , vol.296 , pp. 1029-1031
    • Oeppen, J.1    Vaupel Demography, J.W.2
  • 147
    • 0025801813 scopus 로고
    • Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy
    • Olivetti G, Melissari M, Capasso JM, Anversa P. Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy. Circ Res 68: 1560-1568, 1991.
    • (1991) Circ Res , vol.68 , pp. 1560-1568
    • Olivetti, G.1    Melissari, M.2    Capasso, J.M.3    Anversa, P.4
  • 150
    • 0019215946 scopus 로고
    • Effect of age on the response of the left ventricular ejection fraction to exercise
    • Port S, Cobb FR, Coleman RE, Jones RH. Effect of age on the response of the left ventricular ejection fraction to exercise. N Engl J Med 303: 1133-1137, 1980.
    • (1980) N Engl J Med , vol.303 , pp. 1133-1137
    • Port, S.1    Cobb, F.R.2    Coleman, R.E.3    Jones, R.H.4
  • 151
    • 33645837065 scopus 로고    scopus 로고
    • Vasodilation and vascular control in contracting muscle of the aging human
    • Proctor DN, Parker BA. Vasodilation and vascular control in contracting muscle of the aging human. Microcirculation 13: 315-327, 2006.
    • (2006) Microcirculation , vol.13 , pp. 315-327
    • Proctor, D.N.1    Parker, B.A.2
  • 152
    • 27644445989 scopus 로고    scopus 로고
    • The relationship between shear stress and flow-mediated dilatation: Implications for the assessment of endothelial function
    • Pyke KE, Tschakovsky ME. The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function. J Physiol 568: 357-369, 2005.
    • (2005) J Physiol , vol.568 , pp. 357-369
    • Pyke, K.E.1    Tschakovsky, M.E.2
  • 154
    • 0029037649 scopus 로고
    • Pathophysiology of insulin resistance in human disease
    • Reaven GM. Pathophysiology of insulin resistance in human disease. Physiol Rev 75: 473-486, 1995.
    • (1995) Physiol Rev , vol.75 , pp. 473-486
    • Reaven, G.M.1
  • 157
    • 77956701448 scopus 로고    scopus 로고
    • Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress
    • Rippe C, Lesniewski L, Connell M, LaRocca T, Donato A, Seals D. Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress. Aging Cell 9: 304-312, 2010.
    • (2010) Aging Cell , vol.9 , pp. 304-312
    • Rippe, C.1    Lesniewski, L.2    Connell, M.3    Larocca, T.4    Donato, A.5    Seals, D.6
  • 158
    • 0026080765 scopus 로고
    • Proteoglycans as modulators of growth factor activities
    • Ruoslahti E, Yamaguchi Y. Proteoglycans as modulators of growth factor activities. Cell 64: 867-869, 1991.
    • (1991) Cell , vol.64 , pp. 867-869
    • Ruoslahti, E.1    Yamaguchi, Y.2
  • 159
    • 67349154476 scopus 로고    scopus 로고
    • Functional imaging of atherosclerosis to advance vascular biology
    • Sakalihasan N, Michel JB. Functional imaging of atherosclerosis to advance vascular biology. Eur J Vasc Endovasc Surg 37: 728-734, 2009.
    • (2009) Eur J Vasc Endovasc Surg , vol.37 , pp. 728-734
    • Sakalihasan, N.1    Michel, J.B.2
  • 160
    • 0025185964 scopus 로고
    • Effects of age on myosin and creatine kinase isoforms in left ventricles of Fischer 344 rats
    • Schuyler GT, Yarbrough LR. Effects of age on myosin and creatine kinase isoforms in left ventricles of Fischer 344 rats. Mech Ageing Dev 56: 23-38, 1990.
    • (1990) Mech Ageing Dev , vol.56 , pp. 23-38
    • Schuyler, G.T.1    Yarbrough, L.R.2
  • 162
    • 73449123684 scopus 로고    scopus 로고
    • A comprehensive histopathological evaluation of vascular medial fibrosis: Insights into the pathophysiology of arterial stiffening
    • Selvin E, Najjar SS, Cornish TC, Halushka MK. A comprehensive histopathological evaluation of vascular medial fibrosis: insights into the pathophysiology of arterial stiffening. Atherosclerosis 208: 69-74, 2010.
    • (2010) Atherosclerosis , vol.208 , pp. 69-74
    • Selvin, E.1    Najjar, S.S.2    Cornish, T.C.3    Halushka, M.K.4
  • 163
    • 57749180397 scopus 로고    scopus 로고
    • Serum carboxymethyl-lysine, an advanced glycation end product, is associated with increased aortic pulse wave velocity in adults
    • Semba RD, Najjar SS, Sun K, Lakatta EG, Ferrucci L. Serum carboxymethyl-lysine, an advanced glycation end product, is associated with increased aortic pulse wave velocity in adults. Am J Hypertens 22: 74-79, 2009.
    • (2009) Am J Hypertens , vol.22 , pp. 74-79
    • Semba, R.D.1    Najjar, S.S.2    Sun, K.3    Lakatta, E.G.4    Ferrucci, L.5
  • 164
    • 33748615141 scopus 로고    scopus 로고
    • Moderate calorie restriction improves cardiac remodeling and diastolic dysfunction in the Dahl-SS rat
    • Seymour EM, Parikh RV, Singer AA, Bolling SF. Moderate calorie restriction improves cardiac remodeling and diastolic dysfunction in the Dahl-SS rat. J Mol Cell Cardiol 41: 661-668, 2006.
    • (2006) J Mol Cell Cardiol , vol.41 , pp. 661-668
    • Seymour, E.M.1    Parikh, R.V.2    Singer, A.A.3    Bolling, S.F.4
  • 165
    • 64149106514 scopus 로고    scopus 로고
    • Long-term association of brachial artery flow-mediated vasodilation and cardiovascular events in middleaged subjects with no apparent heart disease
    • Shechter M, Issachar A, Marai I, Koren-Morag N, Freinark D, Shahar Y, Shechter A, Feinberg MS. Long-term association of brachial artery flow-mediated vasodilation and cardiovascular events in middleaged subjects with no apparent heart disease. Int J Cardiol 134: 52-58, 2009.
    • (2009) Int J Cardiol , vol.134 , pp. 52-58
    • Shechter, M.1    Issachar, A.2    Marai, I.3    Koren-Morag, N.4    Freinark, D.5    Shahar, Y.6    Shechter, A.7    Feinberg, M.S.8
  • 167
    • 78650835776 scopus 로고    scopus 로고
    • Impact of long-term caloric restriction on cardiac senescence: Caloric restriction ameliorates cardiac diastolic dysfunction associated with aging
    • Shinmura K, Tamaki K, Sano M, Murata M, Yamakawa H, Ishida H, Fukuda K. Impact of long-term caloric restriction on cardiac senescence: caloric restriction ameliorates cardiac diastolic dysfunction associated with aging. J Mol Cell Cardiol 50: 117-127, 2011.
    • (2011) J Mol Cell Cardiol , vol.50 , pp. 117-127
    • Shinmura, K.1    Tamaki, K.2    Sano, M.3    Murata, M.4    Yamakawa, H.5    Ishida, H.6    Fukuda, K.7
  • 168
    • 68149183625 scopus 로고    scopus 로고
    • Effects of ageing and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles
    • Sindler AL, Delp MD, Reyes R, Wu G, Muller-Delp JM. Effects of ageing and exercise training on eNOS uncoupling in skeletal muscle resistance arterioles. J Physiol 587: 3885-3897, 2009.
    • (2009) J Physiol , vol.587 , pp. 3885-3897
    • Sindler, A.L.1    Delp, M.D.2    Reyes, R.3    Wu, G.4    Muller-Delp, J.M.5
  • 169
    • 80052089449 scopus 로고    scopus 로고
    • Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans
    • Soare A, Cangemi R, Omodei D, Holloszy JO, Fontana L. Long-term calorie restriction, but not endurance exercise, lowers core body temperature in humans. Aging (Albany NY) 3: 374-379, 2011.
    • (2011) Aging (Albany NY) , vol.3 , pp. 374-379
    • Soare, A.1    Cangemi, R.2    Omodei, D.3    Holloszy, J.O.4    Fontana, L.5
  • 170
    • 0030038103 scopus 로고    scopus 로고
    • Oxidative stress, caloric restriction, and aging
    • Sohal RS, Weindruch R. Oxidative stress, caloric restriction, and aging. Science 273: 59-63, 1996.
    • (1996) Science , vol.273 , pp. 59-63
    • Sohal, R.S.1    Weindruch, R.2
  • 171
    • 0033450849 scopus 로고    scopus 로고
    • Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: Inferences from moderate caloric-restricted animals
    • Sonntag WE, Lynch CD, Cefalu WT, Ingram RL, Bennett SA, Thornton PL, Khan AS. Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals. J Gerontol A Biol Sci Med Sci 54: B521-B538, 1999.
    • (1999) J Gerontol a Biol Sci Med Sci , vol.54
    • Sonntag, W.E.1    Lynch, C.D.2    Cefalu, W.T.3    Ingram, R.L.4    Bennett, S.A.5    Thornton, P.L.6    Khan, A.S.7
  • 172
    • 0030929766 scopus 로고    scopus 로고
    • Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-alpha and IL-6 in C3B10RF1 mice
    • Spaulding CC, Walford RL, Effros RB. Calorie restriction inhibits the age-related dysregulation of the cytokines TNF-alpha and IL-6 in C3B10RF1 mice. Mech Ageing Dev 93: 87-94, 1997.
    • (1997) Mech Ageing Dev , vol.93 , pp. 87-94
    • Spaulding, C.C.1    Walford, R.L.2    Effros, R.B.3
  • 173
    • 0020570903 scopus 로고
    • Age-related changes in composition and mechanical properties of the tunica media of the upper thoracic human aorta
    • Spina M, Garbisa S, Hinnie J, Hunter JC, Serafini-Fracassini A. Age-related changes in composition and mechanical properties of the tunica media of the upper thoracic human aorta. Arteriosclerosis 3: 64-76, 1983.
    • (1983) Arteriosclerosis , vol.3 , pp. 64-76
    • Spina, M.1    Garbisa, S.2    Hinnie, J.3    Hunter, J.C.4    Serafini-Fracassini, A.5
  • 175
  • 176
  • 177
    • 33744987670 scopus 로고    scopus 로고
    • Amelioration of age-related inflammation and oxidative stress by PPARgamma activator: Suppression of NF-kappaB by 2,4-thiazolidinedione
    • Sung B, Park S, Yu BP, Chung HY. Amelioration of age-related inflammation and oxidative stress by PPARgamma activator: suppression of NF-kappaB by 2,4-thiazolidinedione. Exp Gerontol 41: 590-599, 2006.
    • (2006) Exp Gerontol , vol.41 , pp. 590-599
    • Sung, B.1    Park, S.2    Yu, B.P.3    Chung, H.Y.4
  • 179
    • 0031438474 scopus 로고    scopus 로고
    • The age-associated alterations in late diastolic function in mice are improved by caloric restriction
    • Taffet GE, Pham TT, Hartley CJ. The age-associated alterations in late diastolic function in mice are improved by caloric restriction. J Gerontol A Biol Sci Med Sci 52: B285-B290, 1997.
    • (1997) J Gerontol a Biol Sci Med Sci , vol.52
    • Taffet, G.E.1    Pham, T.T.2    Hartley, C.J.3
  • 183
    • 0027300282 scopus 로고
    • Long-term caloric restriction improves baroreflex sensitivity in aging Fischer 344 rats
    • Thomas J, Bertrand H, Stacy C, Herlihy JT. Long-term caloric restriction improves baroreflex sensitivity in aging Fischer 344 rats. J Gerontol 48: B151-B155, 1993.
    • (1993) J Gerontol , vol.48
    • Thomas, J.1    Bertrand, H.2    Stacy, C.3    Herlihy, J.T.4
  • 185
    • 79956117923 scopus 로고    scopus 로고
    • NAD(P)H oxidase-derived reactive oxygen species contribute to age-related impairments of endothelium-dependent dilation in rat soleus feed arteries
    • Trott DW, Seawright JW, Luttrell MJ, Woodman CR. NAD(P)H oxidase-derived reactive oxygen species contribute to age-related impairments of endothelium-dependent dilation in rat soleus feed arteries. J Appl Physiol 110: 1171-1180, 2011.
    • (2011) J Appl Physiol , vol.110 , pp. 1171-1180
    • Trott, D.W.1    Seawright, J.W.2    Luttrell, M.J.3    Woodman, C.R.4
  • 189
    • 40949142846 scopus 로고    scopus 로고
    • Mechanisms underlying caloric restriction and lifespan regulation: Implications for vascular aging
    • Ungvari Z, Parrado-Fernandez C, Csiszar A, de Cabo R. Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging. Circ Res 102: 519-528, 2008.
    • (2008) Circ Res , vol.102 , pp. 519-528
    • Ungvari, Z.1    Parrado-Fernandez, C.2    Csiszar, A.3    de Cabo, R.4
  • 194
    • 77949557153 scopus 로고    scopus 로고
    • Prediction of cardiovascular events and all-cause mortality with arterial stiffness: A systematic review and meta-analysis
    • Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol 55: 1318-1327, 2010.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 1318-1327
    • Vlachopoulos, C.1    Aznaouridis, K.2    Stefanadis, C.3
  • 197
    • 0036265323 scopus 로고    scopus 로고
    • Calorie restriction in biosphere 2: Alterations in physiologic, hematologic, hormonal, and biochemical parameters in humans restricted for a 2-year period
    • Walford RL, Mock D, Verdery R, MacCallum T. Calorie restriction in biosphere 2: alterations in physiologic, hematologic, hormonal, and biochemical parameters in humans restricted for a 2-year period. J Gerontol A Biol Sci Med Sci 57: B211-B224, 2002.
    • (2002) J Gerontol a Biol Sci Med Sci , vol.57
    • Walford, R.L.1    Mock, D.2    Verdery, R.3    Maccallum, T.4
  • 198
    • 0030252872 scopus 로고    scopus 로고
    • Age-related alteration of cross-linking amino acids of elastin in human aorta
    • Watanabe M, Sawai T, Nagura H, Suyama K. Age-related alteration of cross-linking amino acids of elastin in human aorta. Tohoku J Exp Med 180: 115-130, 1996.
    • (1996) Tohoku J Exp Med , vol.180 , pp. 115-130
    • Watanabe, M.1    Sawai, T.2    Nagura, H.3    Suyama, K.4
  • 199
    • 0031549576 scopus 로고    scopus 로고
    • Seminars in medicine of the Beth Israel Deaconess Medical Center
    • Caloric intake and aging
    • Weindruch R, Sohal RS. Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. N Engl J Med 337: 986-994, 1997.
    • (1997) N Engl J Med , vol.337 , pp. 986-994
    • Weindruch, R.1    Sohal, R.S.2
  • 201
    • 0024618726 scopus 로고
    • Atherosclerosis research in cynomolgus monkeys (Macaca fascicularis)
    • Weingand KW. Atherosclerosis research in cynomolgus monkeys (Macaca fascicularis). Exp Mol Pathol 50: 1-15, 1989.
    • (1989) Exp Mol Pathol , vol.50 , pp. 1-15
    • Weingand, K.W.1
  • 202
    • 33750908045 scopus 로고    scopus 로고
    • Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: A randomized controlled trial
    • Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Holloszy JO. Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am J Clin Nutr 84: 1033-1042, 2006.
    • (2006) Am J Clin Nutr , vol.84 , pp. 1033-1042
    • Weiss, E.P.1    Racette, S.B.2    Villareal, D.T.3    Fontana, L.4    Steger-May, K.5    Schechtman, K.B.6    Klein, S.7    Holloszy, J.O.8
  • 203
    • 33748449114 scopus 로고    scopus 로고
    • Gender differences in the decline in aerobic capacity and its physiological determinants during the later decades of life
    • Weiss EP, Spina RJ, Holloszy JO, Ehsani AA. Gender differences in the decline in aerobic capacity and its physiological determinants during the later decades of life. J Appl Physiol 101: 938-944, 2006.
    • (2006) J Appl Physiol , vol.101 , pp. 938-944
    • Weiss, E.P.1    Spina, R.J.2    Holloszy, J.O.3    Ehsani, A.A.4
  • 204
    • 46449095385 scopus 로고    scopus 로고
    • Caloric restriction but not exercise-induced reductions in fat mass decrease plasma triiodothyronine concentrations: A randomized controlled trial
    • Weiss EP, Villareal DT, Racette SB, Steger-May K, Premachandra BN, Klein S, Fontana L. Caloric restriction but not exercise-induced reductions in fat mass decrease plasma triiodothyronine concentrations: a randomized controlled trial. Rejuvenation Res 11: 605-609, 2008.
    • (2008) Rejuvenation Res , vol.11 , pp. 605-609
    • Weiss, E.P.1    Villareal, D.T.2    Racette, S.B.3    Steger-May, K.4    Premachandra, B.N.5    Klein, S.6    Fontana, L.7
  • 205
    • 79955749859 scopus 로고    scopus 로고
    • Lifelong caloric restriction prevents age-induced oxidative stress in the sympathoadrenal system of Fischer 344 Brown Norway rats
    • Whidden MA, Kirichenko N, Halici Z, Erdos B, Foster TC, Tumer N. Lifelong caloric restriction prevents age-induced oxidative stress in the sympathoadrenal system of Fischer 344 Brown Norway rats. Biochem Biophys Res Commun 408: 454-458, 2011.
    • (2011) Biochem Biophys Res Commun , vol.408 , pp. 454-458
    • Whidden, M.A.1    Kirichenko, N.2    Halici, Z.3    Erdos, B.4    Foster, T.C.5    Tumer, N.6
  • 208
    • 35948936851 scopus 로고    scopus 로고
    • Caloric restriction, the traditional Okinawan diet, and healthy aging: The diet of the world's longest-lived people and its potential impact on morbidity and life span
    • Willcox BJ, Willcox DC, Todoriki H, Fujiyoshi A, Yano K, He Q, Curb JD, Suzuki M. Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span. Ann NY Acad Sci 1114: 434-455, 2007.
    • (2007) Ann NY Acad Sci , vol.1114 , pp. 434-455
    • Willcox, B.J.1    Willcox, D.C.2    Todoriki, H.3    Fujiyoshi, A.4    Yano, K.5    He, Q.6    Curb, J.D.7    Suzuki, M.8
  • 209
    • 77951598531 scopus 로고    scopus 로고
    • The Okinawan diet: Health implications of a low-calorie, nutrient-dense, antioxidant-rich dietary pattern low in glycemic load
    • Willcox DC, Willcox BJ, Todoriki H, Suzuki M. The Okinawan diet: health implications of a low-calorie, nutrient-dense, antioxidant-rich dietary pattern low in glycemic load. J Am Coll Nutr 28, Suppl: 500S-516S, 2009.
    • (2009) J Am Coll Nutr , vol.28 , Issue.SUPPL.
    • Willcox, D.C.1    Willcox, B.J.2    Todoriki, H.3    Suzuki, M.4
  • 211
    • 0037838859 scopus 로고    scopus 로고
    • Ceramide- induced and age-associated increase in macrophage COX-2 expres-sion is mediated through up-regulation of NF-kappa B activity
    • Wu D, Marko M, Claycombe K, Paulson KE, Meydani SN. Ceramide- induced and age-associated increase in macrophage COX-2 expres-sion is mediated through up-regulation of NF-kappa B activity. J Biol Chem 278: 10983-10992, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 10983-10992
    • Wu, D.1    Marko, M.2    Claycombe, K.3    Paulson, K.E.4    Meydani, S.N.5
  • 213
    • 34248196019 scopus 로고    scopus 로고
    • Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: The Cardiovascular Health Study
    • Yeboah J, Crouse JR, Hsu FC, Burke GL, Herrington DM. Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation 115: 2390-2397, 2007.
    • (2007) Circulation , vol.115 , pp. 2390-2397
    • Yeboah, J.1    Crouse, J.R.2    Hsu, F.C.3    Burke, G.L.4    Herrington, D.M.5
  • 214
    • 77957820976 scopus 로고    scopus 로고
    • Caloric restriction improves endothelial dysfunction during vascular aging: Effects on nitric oxide synthase isoforms and oxidative stress in rat aorta
    • Zanetti M, Gortan CG, Burekovic I, Barazzoni R, Stebel M, Guarnieri G. Caloric restriction improves endothelial dysfunction during vascular aging: Effects on nitric oxide synthase isoforms and oxidative stress in rat aorta. Exp Gerontol 45: 848-855, 2010.
    • (2010) Exp Gerontol , vol.45 , pp. 848-855
    • Zanetti, M.1    Gortan, C.G.2    Burekovic, I.3    Barazzoni, R.4    Stebel, M.5    Guarnieri, G.6
  • 215
    • 40349108268 scopus 로고    scopus 로고
    • Coronary artery disease among asymptomatic diabetic and nondiabetic patients undergoing coronary computed tomography angiography
    • Zeina AR, Odeh M, Rosenschein U, Zaid G, Barmeir E. Coronary artery disease among asymptomatic diabetic and nondiabetic patients undergoing coronary computed tomography angiography. Coron Artery Dis 19: 37-41, 2008.
    • (2008) Coron Artery Dis , vol.19 , pp. 37-41
    • Zeina, A.R.1    Odeh, M.2    Rosenschein, U.3    Zaid, G.4    Barmeir, E.5
  • 217
    • 3242720519 scopus 로고    scopus 로고
    • Circulating adiponectin levels increase in rats on caloric restriction: The potential for insulin sensitization
    • Zhu M, Miura J, Lu LX, Bernier M, DeCabo R, Lane MA, Roth GS, Ingram DK. Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization. Exp Gerontol 39: 1049-1059, 2004.
    • (2004) Exp Gerontol , vol.39 , pp. 1049-1059
    • Zhu, M.1    Miura, J.2    Lu, L.X.3    Bernier, M.4    Decabo, R.5    Lane, M.A.6    Roth, G.S.7    Ingram, D.K.8
  • 218
    • 1442265690 scopus 로고    scopus 로고
    • Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction
    • Zou Y, Jung KJ, Kim JW, Yu BP, Chung HY. Alteration of soluble adhesion molecules during aging and their modulation by calorie restriction. FASEB J 18: 320-322, 2004.
    • (2004) FASEB J , vol.18 , pp. 320-322
    • Zou, Y.1    Jung, K.J.2    Kim, J.W.3    Yu, B.P.4    Chung, H.Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.