Effects of Purifying and Adaptive Selection on Regional Variation in Human mtDNA

Science

Volumn 303, Issue 5655, 2004, Pages 223-226

  Ruiz Pesini, Eduardo ^a   Mishmar, Dan ^a   Brandon, Martin ^a   Procaccio, Vincent ^a   Wallace, Douglas C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CORRELATION METHODS; DNA SEQUENCES; HEALTH CARE; MUTAGENESIS;

ENERGY DEFICIENCY DISEASES;

BIOMEDICAL ENGINEERING;

MITOCHONDRIAL DNA;

ADAPTATION; DNA; PHYLOGENETICS;

ADAPTATION; AFRICA; AMINO ACID SUBSTITUTION; ARTICLE; CLIMATE; DNA PURIFICATION; DNA SEQUENCE; ENERGY; EUROPE; GENE FREQUENCY; GENE MUTATION; GENETIC CONSERVATION; GENETIC VARIABILITY; HUMAN; LATITUDE; LONGEVITY; NUCLEIC ACID BASE SUBSTITUTION; PHYLOGENY; PRIORITY JOURNAL; RUSSIAN FEDERATION;

ADAPTATION, PHYSIOLOGICAL; AFRICA; ARCTIC REGIONS; ASIA; CLIMATE; COLD CLIMATE; CONSERVED SEQUENCE; CONTINENTAL POPULATION GROUPS; DNA, MITOCHONDRIAL; EMIGRATION AND IMMIGRATION; ENERGY METABOLISM; EUROPE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; LONGEVITY; METABOLIC DISEASES; MITOCHONDRIA; MUTATION; NEURODEGENERATIVE DISEASES; PHENOTYPE; PHYLOGENY; SELECTION (GENETICS); SIBERIA; VARIATION (GENETICS);

EID: 0347356538     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1088434     Document Type: Article

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28. Supported by NIH grants NS21328, AG13154, NS37167, and HL64017, as well as an Ellison Medical Foundation Senior Investigator Award awarded to D.C.W.