메뉴 건너뛰기




Volumn 556, Issue 1, 2015, Pages 27-34

Regulation of rDNA transcription in response to growth factors, nutrients and energy

Author keywords

Amino acids; Energy; Growth factors; MTORC1; Nutrients; RDNA transcription

Indexed keywords

DNA DIRECTED RNA POLYMERASE; GROWTH FACTOR; RIBOSOME DNA; RIBOSOME RNA; ADENOSINE TRIPHOSPHATE; AMINO ACID; SIGNAL PEPTIDE;

EID: 84922662987     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2014.11.010     Document Type: Review
Times cited : (74)

References (118)
  • 1
    • 84863838332 scopus 로고    scopus 로고
    • Normal and cancer cell metabolism: lymphocytes and lymphoma
    • Altman B.J., Dang C.V. Normal and cancer cell metabolism: lymphocytes and lymphoma. FEBS J. 2012, 279:2598-2609.
    • (2012) FEBS J. , vol.279 , pp. 2598-2609
    • Altman, B.J.1    Dang, C.V.2
  • 3
    • 84866431363 scopus 로고    scopus 로고
    • Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1
    • Bar-Peled L., Schweitzer L.D., Zoncu R., Sabatini D.M. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell 2012, 150:1196-1208.
    • (2012) Cell , vol.150 , pp. 1196-1208
    • Bar-Peled, L.1    Schweitzer, L.D.2    Zoncu, R.3    Sabatini, D.M.4
  • 4
    • 78649639782 scopus 로고    scopus 로고
    • Arginine-induced stimulation of protein synthesis and survival in IPEC-J2 cells is mediated by mTOR but not nitric oxide
    • Bauchart-Thevret C., Cui L., Wu G., Burrin D.G. Arginine-induced stimulation of protein synthesis and survival in IPEC-J2 cells is mediated by mTOR but not nitric oxide. Am. J. Physiol. Endocrinol. Metab. 2010, 299:E899-E909.
    • (2010) Am. J. Physiol. Endocrinol. Metab. , vol.299 , pp. E899-E909
    • Bauchart-Thevret, C.1    Cui, L.2    Wu, G.3    Burrin, D.G.4
  • 5
    • 84877752572 scopus 로고    scopus 로고
    • Stalling the engine of resistance: targeting cancer metabolism to overcome therapeutic resistance
    • Butler E.B., Zhao Y., Muñoz-Pinedo C., Lu J., Tan M. Stalling the engine of resistance: targeting cancer metabolism to overcome therapeutic resistance. Cancer Res. 2013, 73:2709-2717.
    • (2013) Cancer Res. , vol.73 , pp. 2709-2717
    • Butler, E.B.1    Zhao, Y.2    Muñoz-Pinedo, C.3    Lu, J.4    Tan, M.5
  • 7
    • 84876884110 scopus 로고    scopus 로고
    • Dysregulation of the basal RNA polymerase transcription apparatus in cancer
    • Bywater M.J., Pearson R.B., McArthur G.A., Hannan R.D. Dysregulation of the basal RNA polymerase transcription apparatus in cancer. Nat. Rev. Cancer 2013, 13:299-314.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 299-314
    • Bywater, M.J.1    Pearson, R.B.2    McArthur, G.A.3    Hannan, R.D.4
  • 9
    • 0033429204 scopus 로고    scopus 로고
    • Nutrients differentially regulate multiple translation factors and their control by insulin
    • Campbell L.E., Wang X., Proud C.G. Nutrients differentially regulate multiple translation factors and their control by insulin. Biochem. J. 1999, 344(Pt 2):433-441.
    • (1999) Biochem. J. , vol.344 , pp. 433-441
    • Campbell, L.E.1    Wang, X.2    Proud, C.G.3
  • 12
    • 84864040884 scopus 로고    scopus 로고
    • Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells
    • Chen J.-Q., Russo J. Dysregulation of glucose transport, glycolysis, TCA cycle and glutaminolysis by oncogenes and tumor suppressors in cancer cells. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 2012, 1826:370-384.
    • (2012) Biochimica et Biophysica Acta (BBA)-Reviews on Cancer , vol.1826 , pp. 370-384
    • Chen, J.-Q.1    Russo, J.2
  • 14
    • 84908192544 scopus 로고    scopus 로고
    • The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation
    • Csibi A., Lee G., Yoon S.O., Tong H., Ilter D., Elia I., Fendt S.M., Roberts T.M., Blenis J. The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation. Curr. Biol. 2014, 24:2274-2280.
    • (2014) Curr. Biol. , vol.24 , pp. 2274-2280
    • Csibi, A.1    Lee, G.2    Yoon, S.O.3    Tong, H.4    Ilter, D.5    Elia, I.6    Fendt, S.M.7    Roberts, T.M.8    Blenis, J.9
  • 15
    • 84861975431 scopus 로고    scopus 로고
    • Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis
    • Daye D., Wellen K.E. Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis. Semin. Cell Dev. Biol. 2012, 23:362-369.
    • (2012) Semin. Cell Dev. Biol. , vol.23 , pp. 362-369
    • Daye, D.1    Wellen, K.E.2
  • 16
    • 0028253641 scopus 로고
    • CHO cells transformed by the translation factor eIF-4E display increased c-myc expression, but require overexpression of Max for tumorigenicity
    • De Benedetti A., Joshi B., Graff J., Zimmer S. CHO cells transformed by the translation factor eIF-4E display increased c-myc expression, but require overexpression of Max for tumorigenicity. Mol. Cell. Differ. 1994, 2:347-371.
    • (1994) Mol. Cell. Differ. , vol.2 , pp. 347-371
    • De Benedetti, A.1    Joshi, B.2    Graff, J.3    Zimmer, S.4
  • 17
    • 65349143672 scopus 로고    scopus 로고
    • What the nucleolus says to a tumour pathologist
    • Derenzini M., Montanaro L., Treré D. What the nucleolus says to a tumour pathologist. Histopathology 2009, 54:753-762.
    • (2009) Histopathology , vol.54 , pp. 753-762
    • Derenzini, M.1    Montanaro, L.2    Treré, D.3
  • 20
    • 84908692035 scopus 로고    scopus 로고
    • Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease
    • Diesch J., Hannan R., Sanij E. Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease. Cell Biosci. 2014, 4:43.
    • (2014) Cell Biosci. , vol.4 , pp. 43
    • Diesch, J.1    Hannan, R.2    Sanij, E.3
  • 24
    • 23044474905 scopus 로고    scopus 로고
    • Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?
    • Fuchs B.C., Bode B.P. Amino acid transporters ASCT2 and LAT1 in cancer: partners in crime?. Semin. Cancer Biol. 2005, 15:254-266.
    • (2005) Semin. Cancer Biol. , vol.15 , pp. 254-266
    • Fuchs, B.C.1    Bode, B.P.2
  • 25
    • 84868610892 scopus 로고    scopus 로고
    • Glyceraldehyde-3-phosphate dehydrogenase: a promising target for molecular therapy in hepatocellular carcinoma
    • Ganapathy-Kanniappan S., Kunjithapatham R., Geschwind J.-F. Glyceraldehyde-3-phosphate dehydrogenase: a promising target for molecular therapy in hepatocellular carcinoma. Oncotarget 2012, 3:940.
    • (2012) Oncotarget , vol.3 , pp. 940
    • Ganapathy-Kanniappan, S.1    Kunjithapatham, R.2    Geschwind, J.-F.3
  • 28
    • 14744297005 scopus 로고    scopus 로고
    • Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development
    • Grewal S.S., Li L., Orian A., Eisenman R.N., Edgar B.A. Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development. Nat. Cell Biol. 2005, 7:295-302.
    • (2005) Nat. Cell Biol. , vol.7 , pp. 295-302
    • Grewal, S.S.1    Li, L.2    Orian, A.3    Eisenman, R.N.4    Edgar, B.A.5
  • 29
    • 0038506040 scopus 로고    scopus 로고
    • Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus
    • Grummt I. Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus. Genes Dev. 2003, 17:1691-1702.
    • (2003) Genes Dev. , vol.17 , pp. 1691-1702
    • Grummt, I.1
  • 30
    • 78049261451 scopus 로고    scopus 로고
    • Wisely chosen paths-regulation of rRNA synthesis
    • Grummt I. Wisely chosen paths-regulation of rRNA synthesis. FEBS J. 2010, 277:4626-4639.
    • (2010) FEBS J. , vol.277 , pp. 4626-4639
    • Grummt, I.1
  • 31
    • 0017231359 scopus 로고
    • Amino acid starvation affects the initiation frequency of nucleolar RNA polymerase
    • Grummt I., Smith V.A., Grummt F. Amino acid starvation affects the initiation frequency of nucleolar RNA polymerase. Cell 1976, 7:439-445.
    • (1976) Cell , vol.7 , pp. 439-445
    • Grummt, I.1    Smith, V.A.2    Grummt, F.3
  • 33
    • 84862777407 scopus 로고    scopus 로고
    • Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
    • Han J.M., Jeong S.J., Park M.C., Kim G., Kwon N.H., Kim H.K., Ha S.H., Ryu S.H., Kim S. Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway. Cell 2012, 149:410-424.
    • (2012) Cell , vol.149 , pp. 410-424
    • Han, J.M.1    Jeong, S.J.2    Park, M.C.3    Kim, G.4    Kwon, N.H.5    Kim, H.K.6    Ha, S.H.7    Ryu, S.H.8    Kim, S.9
  • 34
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 35
    • 0242637318 scopus 로고    scopus 로고
    • MTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF
    • Hannan K.M., Brandenburger Y., Jenkins A., Sharkey K., Cavanaugh A., Rothblum L., Moss T., Poortinga G., McArthur G.A., Pearson R.B. mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. Mol. Cell. Biol. 2003, 23:8862-8877.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8862-8877
    • Hannan, K.M.1    Brandenburger, Y.2    Jenkins, A.3    Sharkey, K.4    Cavanaugh, A.5    Rothblum, L.6    Moss, T.7    Poortinga, G.8    McArthur, G.A.9    Pearson, R.B.10
  • 36
    • 79952126044 scopus 로고    scopus 로고
    • Signaling to the ribosome in cancer-it is more than just mTORC1
    • Hannan K.M., Sanij E., Hein N., Hannan R.D., Pearson R.B. Signaling to the ribosome in cancer-it is more than just mTORC1. IUBMB Life 2011, 63:79-85.
    • (2011) IUBMB Life , vol.63 , pp. 79-85
    • Hannan, K.M.1    Sanij, E.2    Hein, N.3    Hannan, R.D.4    Pearson, R.B.5
  • 37
    • 84880365124 scopus 로고    scopus 로고
    • Targeting RNA polymerase I transcription and the nucleolus for cancer therapy
    • Hannan R.D., Drygin D., Pearson R.B. Targeting RNA polymerase I transcription and the nucleolus for cancer therapy. Expert Opin. Ther. Targets 2013, 17:873-878.
    • (2013) Expert Opin. Ther. Targets , vol.17 , pp. 873-878
    • Hannan, R.D.1    Drygin, D.2    Pearson, R.B.3
  • 38
    • 0032486268 scopus 로고    scopus 로고
    • Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
    • Hara K., Yonezawa K., Weng Q.-P., Kozlowski M.T., Belham C., Avruch J. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J. Biol. Chem. 1998, 273:14484-14494.
    • (1998) J. Biol. Chem. , vol.273 , pp. 14484-14494
    • Hara, K.1    Yonezawa, K.2    Weng, Q.-P.3    Kozlowski, M.T.4    Belham, C.5    Avruch, J.6
  • 44
    • 79952104568 scopus 로고    scopus 로고
    • MTOR couples cellular nutrient sensing to organismal metabolic homeostasis
    • Howell J.J., Manning B.D. mTOR couples cellular nutrient sensing to organismal metabolic homeostasis. Trends Endocrinol. Metab. 2011, 22:94-102.
    • (2011) Trends Endocrinol. Metab. , vol.22 , pp. 94-102
    • Howell, J.J.1    Manning, B.D.2
  • 45
    • 84912533536 scopus 로고    scopus 로고
    • MTORC1 signaling controls multiple steps in ribosome biogenesis
    • Iadevaia V., Liu R., Proud C.G. mTORC1 signaling controls multiple steps in ribosome biogenesis. Semin. Cell Dev. Biol. 2014, 10.1016/j.semcdb.2014.08.004.
    • (2014) Semin. Cell Dev. Biol.
    • Iadevaia, V.1    Liu, R.2    Proud, C.G.3
  • 46
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki K., Li Y., Xu T., Guan K.-L. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 2003, 17:1829-1834.
    • (2003) Genes Dev. , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.-L.4
  • 47
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K., Zhu T., Guan K.-L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115:577-590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.-L.3
  • 49
    • 1542305503 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients
    • James M.J., Zomerdijk J.C. Phosphatidylinositol 3-kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients. J. Biol. Chem. 2004, 279:8911-8918.
    • (2004) J. Biol. Chem. , vol.279 , pp. 8911-8918
    • James, M.J.1    Zomerdijk, J.C.2
  • 50
    • 84899573241 scopus 로고    scopus 로고
    • Glutaminase regulation in cancer cells: a druggable chain of events
    • Katt W.P., Cerione R.A. Glutaminase regulation in cancer cells: a druggable chain of events. Drug Discov. Today 2014, 19:450-457.
    • (2014) Drug Discov. Today , vol.19 , pp. 450-457
    • Katt, W.P.1    Cerione, R.A.2
  • 51
    • 0034633761 scopus 로고    scopus 로고
    • Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo
    • Kim S., Li Q., Dang C.V., Lee L.A. Induction of ribosomal genes and hepatocyte hypertrophy by adenovirus-mediated expression of c-Myc in vivo. Proc. Natl. Acad. Sci. 2000, 97:11198-11202.
    • (2000) Proc. Natl. Acad. Sci. , vol.97 , pp. 11198-11202
    • Kim, S.1    Li, Q.2    Dang, C.V.3    Lee, L.A.4
  • 53
    • 84894486696 scopus 로고    scopus 로고
    • Nutrient regulation of the mTOR complex 1 signaling pathway
    • Kim S.G., Buel G.R., Blenis J. Nutrient regulation of the mTOR complex 1 signaling pathway. Mol. Cells 2013, 35:463-473.
    • (2013) Mol. Cells , vol.35 , pp. 463-473
    • Kim, S.G.1    Buel, G.R.2    Blenis, J.3
  • 55
    • 0034655785 scopus 로고    scopus 로고
    • Glucose and amino acids modulate translation factor activation by growth factors in PC12 cells
    • Kleijn M., Proud C.G. Glucose and amino acids modulate translation factor activation by growth factors in PC12 cells. Biochem. J. 2000, 347:399-406.
    • (2000) Biochem. J. , vol.347 , pp. 399-406
    • Kleijn, M.1    Proud, C.G.2
  • 59
    • 21244456553 scopus 로고    scopus 로고
    • Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency
    • Long X., Ortiz-Vega S., Lin Y., Avruch J. Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J. Biol. Chem. 2005, 280:23433-23436.
    • (2005) J. Biol. Chem. , vol.280 , pp. 23433-23436
    • Long, X.1    Ortiz-Vega, S.2    Lin, Y.3    Avruch, J.4
  • 60
    • 0027931137 scopus 로고
    • Modulation of transcription of rRNA genes by rapamycin
    • Mahajan P.B. Modulation of transcription of rRNA genes by rapamycin. Int. J. Immunopharmacol. 1994, 16:711-721.
    • (1994) Int. J. Immunopharmacol. , vol.16 , pp. 711-721
    • Mahajan, P.B.1
  • 61
    • 1542343973 scopus 로고    scopus 로고
    • MTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability
    • Mayer C., Zhao J., Yuan X., Grummt I. mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes Dev. 2004, 18:423-434.
    • (2004) Genes Dev. , vol.18 , pp. 423-434
    • Mayer, C.1    Zhao, J.2    Yuan, X.3    Grummt, I.4
  • 62
    • 84875238269 scopus 로고    scopus 로고
    • Regulation of Pol III transcription by nutrient and stress signaling pathways
    • Moir R.D., Willis I.M. Regulation of Pol III transcription by nutrient and stress signaling pathways. Biochim. Biophys. Acta 2013, 1829:361-375.
    • (2013) Biochim. Biophys. Acta , vol.1829 , pp. 361-375
    • Moir, R.D.1    Willis, I.M.2
  • 63
    • 33748747706 scopus 로고    scopus 로고
    • Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro
    • Momcilovic M., Hong S.-P., Carlson M. Mammalian TAK1 activates Snf1 protein kinase in yeast and phosphorylates AMP-activated protein kinase in vitro. J. Biol. Chem. 2006, 281:25336-25343.
    • (2006) J. Biol. Chem. , vol.281 , pp. 25336-25343
    • Momcilovic, M.1    Hong, S.-P.2    Carlson, M.3
  • 64
  • 67
    • 77952583684 scopus 로고    scopus 로고
    • Maturation of eukaryotic ribosomes: acquisition of functionality
    • Panse V.G., Johnson A.W. Maturation of eukaryotic ribosomes: acquisition of functionality. Trends Biochem. Sci. 2010, 35:260-266.
    • (2010) Trends Biochem. Sci. , vol.35 , pp. 260-266
    • Panse, V.G.1    Johnson, A.W.2
  • 73
    • 84895417268 scopus 로고    scopus 로고
    • Targeting RNA polymerase I to treat MYC-driven cancer
    • Poortinga G., Quinn L., Hannan R. Targeting RNA polymerase I to treat MYC-driven cancer. Oncogene 2014, 10.1038/onc.2014.13.
    • (2014) Oncogene
    • Poortinga, G.1    Quinn, L.2    Hannan, R.3
  • 74
    • 84880352272 scopus 로고    scopus 로고
    • Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers
    • Pourdehnad M., Truitt M.L., Siddiqi I.N., Ducker G.S., Shokat K.M., Ruggero D. Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:11988-11993.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 11988-11993
    • Pourdehnad, M.1    Truitt, M.L.2    Siddiqi, I.N.3    Ducker, G.S.4    Shokat, K.M.5    Ruggero, D.6
  • 76
    • 0037363075 scopus 로고    scopus 로고
    • Does the ribosome translate cancer?
    • Ruggero D., Pandolfi P.P. Does the ribosome translate cancer?. Nat. Rev. Cancer 2003, 3:179-192.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 179-192
    • Ruggero, D.1    Pandolfi, P.P.2
  • 77
    • 13244264948 scopus 로고    scopus 로고
    • RNA-polymerase-I-directed rDNA transcription, life and works
    • Russell J., Zomerdijk J.C. RNA-polymerase-I-directed rDNA transcription, life and works. Trends Biochem. Sci. 2005, 30:87-96.
    • (2005) Trends Biochem. Sci. , vol.30 , pp. 87-96
    • Russell, J.1    Zomerdijk, J.C.2
  • 79
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Sancak Y., Bar-Peled L., Zoncu R., Markhard A.L., Nada S., Sabatini D.M. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010, 141:290-303.
    • (2010) Cell , vol.141 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6
  • 81
    • 0033551378 scopus 로고    scopus 로고
    • The role of c-myc in cellular growth control
    • Schmidt E.V. The role of c-myc in cellular growth control. Oncogene 1999, 18:2988-2996.
    • (1999) Oncogene , vol.18 , pp. 2988-2996
    • Schmidt, E.V.1
  • 82
    • 84855839708 scopus 로고    scopus 로고
    • RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation
    • Schneider D.A. RNA polymerase I activity is regulated at multiple steps in the transcription cycle: recent insights into factors that influence transcription elongation. Gene 2012, 493:176-184.
    • (2012) Gene , vol.493 , pp. 176-184
    • Schneider, D.A.1
  • 83
    • 84869009687 scopus 로고    scopus 로고
    • How cancer metabolism is tuned for proliferation and vulnerable to disruption
    • Schulze A., Harris A.L. How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature 2012, 491:364-373.
    • (2012) Nature , vol.491 , pp. 364-373
    • Schulze, A.1    Harris, A.L.2
  • 85
    • 0035831451 scopus 로고    scopus 로고
    • Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B
    • Sekiguchi T., Hirose E., Nakashima N., Ii M., Nishimoto T. Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B. J. Biol. Chem. 2001, 276:7246-7257.
    • (2001) J. Biol. Chem. , vol.276 , pp. 7246-7257
    • Sekiguchi, T.1    Hirose, E.2    Nakashima, N.3    Ii, M.4    Nishimoto, T.5
  • 86
    • 84894523716 scopus 로고    scopus 로고
    • Making new contacts: the mTOR network in metabolism and signalling crosstalk
    • Shimobayashi M., Hall M.N. Making new contacts: the mTOR network in metabolism and signalling crosstalk. Nat. Rev. Mol. Cell Biol. 2014, 15:155-162.
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 155-162
    • Shimobayashi, M.1    Hall, M.N.2
  • 87
    • 67349121053 scopus 로고    scopus 로고
    • C-Myc induces changes in higher order rDNA structure on stimulation of quiescent cells
    • Shiue C.N., Berkson R.G., Wright A.P. c-Myc induces changes in higher order rDNA structure on stimulation of quiescent cells. Oncogene 2009, 28:1833-1842.
    • (2009) Oncogene , vol.28 , pp. 1833-1842
    • Shiue, C.N.1    Berkson, R.G.2    Wright, A.P.3
  • 88
    • 21244480367 scopus 로고    scopus 로고
    • The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
    • Smith E.M., Finn S.G., Tee A.R., Browne G.J., Proud C.G. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J. Biol. Chem. 2005, 280:18717-18727.
    • (2005) J. Biol. Chem. , vol.280 , pp. 18717-18727
    • Smith, E.M.1    Finn, S.G.2    Tee, A.R.3    Browne, G.J.4    Proud, C.G.5
  • 89
    • 50849087976 scopus 로고    scopus 로고
    • The splice variants of UBF differentially regulate RNA polymerase I transcription elongation in response to ERK phosphorylation
    • Stefanovsky V.Y., Moss T. The splice variants of UBF differentially regulate RNA polymerase I transcription elongation in response to ERK phosphorylation. Nucleic Acids Res. 2008, 36:5093-5101.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 5093-5101
    • Stefanovsky, V.Y.1    Moss, T.2
  • 90
    • 0035930330 scopus 로고    scopus 로고
    • An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF
    • Stefanovsky V.Y., Pelletier G., Hannan R., Gagnon-Kugler T., Rothblum L.I., Moss T. An immediate response of ribosomal transcription to growth factor stimulation in mammals is mediated by ERK phosphorylation of UBF. Mol. Cell 2001, 8:1063-1073.
    • (2001) Mol. Cell , vol.8 , pp. 1063-1073
    • Stefanovsky, V.Y.1    Pelletier, G.2    Hannan, R.3    Gagnon-Kugler, T.4    Rothblum, L.I.5    Moss, T.6
  • 91
    • 33344474082 scopus 로고    scopus 로고
    • Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling
    • Stefanovsky V., Langlois F., Gagnon-Kugler T., Rothblum L.I., Moss T. Growth factor signaling regulates elongation of RNA polymerase I transcription in mammals via UBF phosphorylation and r-chromatin remodeling. Mol. Cell 2006, 21:629-639.
    • (2006) Mol. Cell , vol.21 , pp. 629-639
    • Stefanovsky, V.1    Langlois, F.2    Gagnon-Kugler, T.3    Rothblum, L.I.4    Moss, T.5
  • 92
    • 33344467962 scopus 로고    scopus 로고
    • ERK modulates DNA bending and enhancesome structure by phosphorylating HMG1-boxes 1 and 2 of the RNA polymerase I transcription factor UBF
    • Stefanovsky V.Y., Langlois F., Bazett-Jones D., Pelletier G., Moss T. ERK modulates DNA bending and enhancesome structure by phosphorylating HMG1-boxes 1 and 2 of the RNA polymerase I transcription factor UBF. Biochemistry 2006, 45:3626-3634.
    • (2006) Biochemistry , vol.45 , pp. 3626-3634
    • Stefanovsky, V.Y.1    Langlois, F.2    Bazett-Jones, D.3    Pelletier, G.4    Moss, T.5
  • 93
    • 38049082048 scopus 로고    scopus 로고
    • Genomic architecture and inheritance of human ribosomal RNA gene clusters
    • Stults D.M., Killen M.W., Pierce H.H., Pierce A.J. Genomic architecture and inheritance of human ribosomal RNA gene clusters. Genome Res. 2008, 18:13-18.
    • (2008) Genome Res. , vol.18 , pp. 13-18
    • Stults, D.M.1    Killen, M.W.2    Pierce, H.H.3    Pierce, A.J.4
  • 95
    • 37349014081 scopus 로고    scopus 로고
    • Tel2 regulates the stability of PI3K-related protein kinases
    • Takai H., Wang R.C., Takai K.K., Yang H., de Lange T. Tel2 regulates the stability of PI3K-related protein kinases. Cell 2007, 131:1248-1259.
    • (2007) Cell , vol.131 , pp. 1248-1259
    • Takai, H.1    Wang, R.C.2    Takai, K.K.3    Yang, H.4    de Lange, T.5
  • 96
    • 84891377474 scopus 로고    scopus 로고
    • Role of amino acid transporters in amino acid sensing
    • Taylor P.M. Role of amino acid transporters in amino acid sensing. Am. J. Clin. Nutr. 2014, 99:223S-230S.
    • (2014) Am. J. Clin. Nutr. , vol.99 , pp. 223S-230S
    • Taylor, P.M.1
  • 97
    • 0042701991 scopus 로고    scopus 로고
    • Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
    • Tee A.R., Manning B.D., Roux P.P., Cantley L.C., Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr. Biol. 2003, 13:1259-1268.
    • (2003) Curr. Biol. , vol.13 , pp. 1259-1268
    • Tee, A.R.1    Manning, B.D.2    Roux, P.P.3    Cantley, L.C.4    Blenis, J.5
  • 100
    • 84858007694 scopus 로고    scopus 로고
    • Overexpression of ribosomal RNA in prostate cancer is common but not linked to rDNA promoter hypomethylation
    • Uemura M., Zheng Q., Koh C., Nelson W., Yegnasubramanian S., De Marzo A. Overexpression of ribosomal RNA in prostate cancer is common but not linked to rDNA promoter hypomethylation. Oncogene 2011, 31:1254-1263.
    • (2011) Oncogene , vol.31 , pp. 1254-1263
    • Uemura, M.1    Zheng, Q.2    Koh, C.3    Nelson, W.4    Yegnasubramanian, S.5    De Marzo, A.6
  • 101
    • 55249084500 scopus 로고    scopus 로고
    • Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation
    • Wall M., Poortinga G., Hannan K.M., Pearson R.B., Hannan R.D., McArthur G.A. Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation. Blood 2008, 112:2305-2317.
    • (2008) Blood , vol.112 , pp. 2305-2317
    • Wall, M.1    Poortinga, G.2    Hannan, K.M.3    Pearson, R.B.4    Hannan, R.D.5    McArthur, G.A.6
  • 103
    • 0032528917 scopus 로고    scopus 로고
    • Amino acid availability regulates p70 S6 kinase and multiple translation factors
    • Wang X., Campbell L., Miller C., Proud C. Amino acid availability regulates p70 S6 kinase and multiple translation factors. Biochem. J. 1998, 334:261-267.
    • (1998) Biochem. J. , vol.334 , pp. 261-267
    • Wang, X.1    Campbell, L.2    Miller, C.3    Proud, C.4
  • 104
    • 0032514376 scopus 로고    scopus 로고
    • Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway
    • West M.J., Stoneley M., Willis A.E. Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway. Oncogene 1998, 17:769-780.
    • (1998) Oncogene , vol.17 , pp. 769-780
    • West, M.J.1    Stoneley, M.2    Willis, A.E.3
  • 105
    • 33746792491 scopus 로고    scopus 로고
    • Nascent pre-rRNA overexpression correlates with an adverse prognosis in alveolar rhabdomyosarcoma
    • Williamson D., Lu Y.J., Fang C., Pritchard-Jones K., Shipley J. Nascent pre-rRNA overexpression correlates with an adverse prognosis in alveolar rhabdomyosarcoma. Genes Chromosom. Cancer 2006, 45:839-845.
    • (2006) Genes Chromosom. Cancer , vol.45 , pp. 839-845
    • Williamson, D.1    Lu, Y.J.2    Fang, C.3    Pritchard-Jones, K.4    Shipley, J.5
  • 106
    • 77955281020 scopus 로고    scopus 로고
    • Glutamine addiction: a new therapeutic target in cancer
    • Wise D.R., Thompson C.B. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem. Sci. 2010, 35:427-433.
    • (2010) Trends Biochem. Sci. , vol.35 , pp. 427-433
    • Wise, D.R.1    Thompson, C.B.2
  • 111
    • 84886775476 scopus 로고    scopus 로고
    • Regulation of SirT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability
    • Yang L., Song T., Chen L., Kabra N., Zheng H., Koomen J., Seto E., Chen J. Regulation of SirT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability. Mol. Cell. Biol. 2013, 33:3835-3848.
    • (2013) Mol. Cell. Biol. , vol.33 , pp. 3835-3848
    • Yang, L.1    Song, T.2    Chen, L.3    Kabra, N.4    Zheng, H.5    Koomen, J.6    Seto, E.7    Chen, J.8
  • 112
    • 0036866588 scopus 로고    scopus 로고
    • Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter
    • Yuan X., Zhao J., Zentgraf H., Hoffmann-Rohrer U., Grummt I. Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. EMBO Rep. 2002, 3:1082-1087.
    • (2002) EMBO Rep. , vol.3 , pp. 1082-1087
    • Yuan, X.1    Zhao, J.2    Zentgraf, H.3    Hoffmann-Rohrer, U.4    Grummt, I.5
  • 113
    • 34347402459 scopus 로고    scopus 로고
    • Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
    • Yuneva M., Zamboni N., Oefner P., Sachidanandam R., Lazebnik Y. Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J. Cell Biol. 2007, 178:93-105.
    • (2007) J. Cell Biol. , vol.178 , pp. 93-105
    • Yuneva, M.1    Zamboni, N.2    Oefner, P.3    Sachidanandam, R.4    Lazebnik, Y.5
  • 115
    • 0037291736 scopus 로고    scopus 로고
    • ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth
    • Zhao J., Yuan X., Frödin M., Grummt I. ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. Mol. Cell 2003, 11:405-413.
    • (2003) Mol. Cell , vol.11 , pp. 405-413
    • Zhao, J.1    Yuan, X.2    Frödin, M.3    Grummt, I.4
  • 116
    • 84875890762 scopus 로고    scopus 로고
    • Targeting cellular metabolism to improve cancer therapeutics
    • Zhao Y., Butler E., Tan M. Targeting cellular metabolism to improve cancer therapeutics. Cell Death Dis. 2013, 4:e532.
    • (2013) Cell Death Dis. , vol.4
    • Zhao, Y.1    Butler, E.2    Tan, M.3
  • 117
    • 47549087332 scopus 로고    scopus 로고
    • Signal transduction: linking nutrients to growth
    • Zinzalla V., Hall M.N. Signal transduction: linking nutrients to growth. Nature 2008, 454:287-288.
    • (2008) Nature , vol.454 , pp. 287-288
    • Zinzalla, V.1    Hall, M.N.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.