c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription

Nature Cell Biology

Volumn 7, Issue 3, 2005, Pages 303-310

  Arabi, Azadeh ^a,b   Wu, Siqin ^c   Ridderstråle, Karin ^c   Bierhoff, Holger ^d   Shiue, Chiounan ^a,b   Fatyol, Karoly ^d   Fahlén, Sara ^c   Hydbring, Per ^c   Söderberg, Ola ^e   Grummt, Ingrid ^d   Larsson, Lars Gunnar ^c   Wright, Anthony P H ^a,b  

^a SÖDERTÖRN UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^e UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED RNA POLYMERASE; ESTROGEN RECEPTOR; HISTONE; MAX PROTEIN; MYC PROTEIN; RIBOSOME DNA; SMALL INTERFERING RNA;

ACETYLATION; ANIMAL CELL; ARTICLE; BIOGENESIS; CELL GROWTH; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINE; CELL LINE, TUMOR; CELL NUCLEOLUS; CELL NUCLEUS; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; DNA, RIBOSOMAL; DOWN-REGULATION; HELA CELLS; HISTONES; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LIGANDS; MICROSCOPY, FLUORESCENCE; MODELS, GENETIC; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTO-ONCOGENE PROTEINS C-MYC; RNA POLYMERASE I; RNA, SMALL INTERFERING; TEMPERATURE; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 20044375377     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1225     Document Type: Article

References (30)

1. Oster, S. K., Ho, C. S., Soucie, E. L. & Penn, L. Z. The myc oncogene: MarvelouslY Complex. Adv. Cancer Res. 84, 81-154 (2002).
2. Arabi, A., Rustum, C., Hallberg, E. & Wright, A. P. Accumulation of c-Myc and proteasomes at the nucleoli of cells containing elevated c-Myc protein levels. J. Cell Sci. 116, 1707-1717 (2003).
3. McMahon, S. B., Wood, M. A. & Cole, M. D. The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. Mol. Cell. Biol. 20, 556-562 (2000).
4. Frank, S. R. et al. MYC recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Rep. 4, 575-580 (2003).
5. Johnston, L. A., Prober, D. A., Edgar, B. A., Eisenman, R. N. & Gallant, P. Drosophila myc regulates cellular growth during development. Cell 98, 779-790 (1999).
6. Schuhmacher, M. et al. Control of cell growth by c-Myc in the absence of cell division. Curr. Biol. 9, 1255-1258 (1999).
7. Ruggero, D. & Pandolfi, P. P. Does the ribosome translate cancer? Nature Rev. Cancer 3, 179-192 (2003).
8. Gomez-Roman, N., Grandori, C., Eisenman, R. N. & White, R. J. Direct activation of RNA polymerase III transcription by c-Myc. Nature 421, 290-294 (2003).
9. Poortinga, G. et al. MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation. EMBO J. 23, 3325-3335 (2004).
10. Schlosser, I. et al. A role for c-Myc in the regulation of ribosomal RNA processing. Nucleic Acids Res. 31, 6148-6156 (2003).
11. Salghetti, S. E., Kim, S. Y. & Tansey, W. P. Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc. EMBO J. 18, 717-726 (1999).
12. Flinn, E. M., Busch, C. M. & Wright, A. P. myc boxes, which are conserved in myc family proteins, are signals for protein degradation via the proteasome. Mol. Cell. Biol. 18, 5961-5969 (1998).
13. Kim, S. Y., Herbst, A., Tworkowski, K. A., Salghetti, S. E. & Tansey, W. P. Skp2 regulates Myc protein stability and activity. Mol. Cell 11, 1177-1188 (2003).
14. von der Lehr, N. et al. The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol. Cell 11, 1189-1200 (2003).
15. Welcker, M. et al. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc. Natl Acad. Sci. USA 101, 9085-9090 (2004).
16. Yada, M. et al. Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J. 23, 2116-2125 (2004).
17. Visintin, R. & Amon, A. The nucleolus: the magician's hat for cell cycle tricks. Curr. Opin. Cell Biol. 12, 752 (2000).
18. Grinberg, A. V, Hu, C. D. & Kerppola, T. K. Visualization of Myc/Max/Mad family dimers and the competition for dimerization in living cells. Mol. Cell. Biol. 24, 4294-4308 (2004).
19. O'Sullivan, A. C., Sullivan, G. J. & McStay, B. UBF binding in vivo is not restricted to regulatory sequences within the vertebrate ribosomal DNA repeat. Mol. Cell. Biol. 22, 657-668 (2002).
20. Santoro, R., Li, J. & Grummt, I. The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription. Nature Genet. 32, 393-396 (2002).
21. Mutskov, V. J., Russanova, V. R., Dimitrov, S. I. & Pashev, I. G. Histones associated with non-nucleosomal rat ribosomal genes are acetylated while those bound to nucleosome-organized gene copies are not. J. Biol. Chem. 271, 11852-11857 (1996).
22. Yin, X., Giap, C., Lazo, J. S. & Prochownik, E. V. Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 22, 6151-6159 (2003).
23. Grummt, I. Life on a planet of its own: regulation of RNA polymerase I transcription in the nucleolus. Genes Dev. 17, 1691-1702 (2003).
24. Frank, S. R., Schroeder, M., Fernandez, P., Taubert, S. & Amati, B. Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Genes Dev. 15, 2069-2082 (2001).
25. Halkidou, K., Logan, I. R., Cook, S., Neal, D. E. & Robson, C. N. Putative involvement of the histone acetyltransferase Tip60 in ribosomal gene transcription. Nucleic Acids Res. 32, 1654-1665 (2004).
26. Koberna, K. et al. Ribosomal genes in focus: new transcripts label the dense fibrillar components and form clusters indicative of "Christmas trees" in situ. J. Cell Biol. 157, 743-748 (2002).
27. Elbashir, S. M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494-498 (2001).
28. Seither, P. & Grummt, I. Molecular cloning of RPA2, the gene encoding the second largest subunit of mouse RNA polymerase I. Genomics 37, 135-139 (1996).
29. Boyd, K. E., Wells, J., Gutman, J., Bartley, S. M. & Farnham, P. J. c-Myc target gene specificity is determined by a post-DNAbinding mechanism. Proc. Natl Acad. Sci. USA 95, 13887-13892 (1998).
30. Cheutin, T. et al. Three-dimensional organization of active rRNA genes within the nucleolus. J. Cell Sci. 115, 3297-3307 (2002).