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Volumn 63, Issue 2, 2011, Pages 79-85

Signaling to the ribosome in cancer - It is more than just mTORC1

Author keywords

cancer; PI3K AKT mTORC1; protein synthesis; ribosome

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAS PROTEIN;

EID: 79952126044     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.428     Document Type: Review
Times cited : (37)

References (65)
  • 1
    • 67649814136 scopus 로고    scopus 로고
    • PI3K/PTEN signaling in angiogenesis and tumorigenesis
    • Jiang, B. H., and, Liu, L. Z., (2009) PI3K/PTEN signaling in angiogenesis and tumorigenesis. Adv. Cancer Res 102, 19-65.
    • (2009) Adv. Cancer Res , vol.102 , pp. 19-65
    • Jiang, B.H.1    Liu, L.Z.2
  • 2
    • 70350418625 scopus 로고    scopus 로고
    • MTOR signaling at a glance
    • Laplante, M., and, Sabatini, D. M., (2009) mTOR signaling at a glance. J. Cell. Sci. 122 (Pt 20), 3589-3594.
    • (2009) J. Cell. Sci. , vol.122 , Issue.PART 20 , pp. 3589-3594
    • Laplante, M.1    Sabatini, D.M.2
  • 3
    • 67349241955 scopus 로고    scopus 로고
    • DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
    • Peterson, T. R., Laplante, M., Thoreen, C. C., Sancak, Y., Kang, S. A, Kuehl, W. M., Gray, N. S., and, Sabatini, D. M., (2009) DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 137, 873-886.
    • (2009) Cell , vol.137 , pp. 873-886
    • Peterson, T.R.1    Laplante, M.2    Thoreen, C.C.3    Sancak, Y.4    Kang, S.A.5    Kuehl, W.M.6    Gray, N.S.7    Sabatini, D.M.8
  • 5
    • 70350560575 scopus 로고    scopus 로고
    • Current perspectives on Akt Akt-ivation and Akt-ions
    • Matheny, R. W. Jr., and, Adamo, M. L., (2009) Current perspectives on Akt Akt-ivation and Akt-ions. Exp. Biol. Med. (Maywood) 234, 1264-1270.
    • (2009) Exp. Biol. Med. (Maywood) , vol.234 , pp. 1264-1270
    • Matheny, Jr.R.W.1    Adamo, M.L.2
  • 6
    • 27844445642 scopus 로고    scopus 로고
    • Perturbations of the AKT signaling pathway in human cancer
    • DOI 10.1038/sj.onc.1209085, PII 1209085
    • Altomare, D. A., and, Testa, J. R., (2005) Perturbations of the AKT signaling pathway in human cancer. Oncogene 24, 7455-7464. (Pubitemid 41637985)
    • (2005) Oncogene , vol.24 , Issue.50 , pp. 7455-7464
    • Altomare, D.A.1    Testa, J.R.2
  • 7
    • 60549096247 scopus 로고    scopus 로고
    • Akt-dependent and -independent mechanisms of mTOR regulation in cancer
    • Memmott, R. M., and, Dennis, P. A., (2009) Akt-dependent and -independent mechanisms of mTOR regulation in cancer. Cell Signal. 21, 656-664.
    • (2009) Cell Signal. , vol.21 , pp. 656-664
    • Memmott, R.M.1    Dennis, P.A.2
  • 8
    • 33847397874 scopus 로고    scopus 로고
    • Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
    • DOI 10.1038/ncb1547, PII NCB1547
    • Vander Haar, E., Lee, S. I., Bandhakavi, S., Griffin, T. J., and. Kim, D. H., (2007) Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat. Cell. Biol. 9, 316-323. (Pubitemid 46344611)
    • (2007) Nature Cell Biology , vol.9 , Issue.3 , pp. 316-323
    • Haar, E.V.1    Lee, S.2    Bandhakavi, S.3    Griffin, T.J.4    Kim, D.-H.5
  • 10
    • 0035462613 scopus 로고    scopus 로고
    • Increased expression of UBF is a critical determinant for rRNA synthesis and hypertrophic growth of cardiac myocytes
    • Brandenburger, Y., Jenkins, A., Autelitano, D. J., and, Hannan, R. D., (2001) Increased expression of UBF is a critical determinant for rRNA synthesis and hypertrophic growth of cardiac myocytes. FASEB J. 15, 2051-2053.
    • (2001) FASEB J. , vol.15 , pp. 2051-2053
    • Brandenburger, Y.1    Jenkins, A.2    Autelitano, D.J.3    Hannan, R.D.4
  • 12
    • 0037363075 scopus 로고    scopus 로고
    • Does the ribosome translate cancer?
    • DOI 10.1038/nrc1015
    • Ruggero, D., and, Pandolfi, P. P., (2003) Does the ribosome translate cancer? Nat. Rev. Cancer 3, 179-192. (Pubitemid 37328870)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.3 , pp. 179-192
    • Ruggero, D.1    Pandolfi, P.P.2
  • 13
    • 61449235398 scopus 로고    scopus 로고
    • Not all substrates are treated equally: Implications for mTOR, rapamycin-resistance and cancer therapy
    • Choo, A. Y., and, Blenis, J., (2009) Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy. Cell Cycle 8, 567-572.
    • (2009) Cell Cycle , vol.8 , pp. 567-572
    • Choo, A.Y.1    Blenis, J.2
  • 14
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • Ma, X. M., and, Blenis, J., (2009) Molecular mechanisms of mTOR-mediated translational control. Nat. Rev. Mol. Cell. Biol. 10, 307-318.
    • (2009) Nat. Rev. Mol. Cell. Biol. , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 15
    • 33750044901 scopus 로고    scopus 로고
    • Ribosome biogenesis and cell growth: MTOR coordinates transcription by all three classes of nuclear RNA polymerases
    • DOI 10.1038/sj.onc.1209883, PII 1209883
    • Mayer, C., and, Grummt, I., (2006) Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases. Oncogene 25, 6384-6391. (Pubitemid 44582283)
    • (2006) Oncogene , vol.25 , Issue.48 , pp. 6384-6391
    • Mayer, C.1    Grummt, I.2
  • 16
    • 37549028779 scopus 로고    scopus 로고
    • Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function
    • Jastrzebski, K., Hannan, K. M., Tchoubrieva, E. B., Hannan, R. D., and. Pearson, R. B., (2007) Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function. Growth Factors 25, 209-226.
    • (2007) Growth Factors , vol.25 , pp. 209-226
    • Jastrzebski, K.1    Hannan, K.M.2    Tchoubrieva, E.B.3    Hannan, R.D.4    Pearson, R.B.5
  • 17
    • 0030915898 scopus 로고    scopus 로고
    • Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70(s6k)
    • DOI 10.1093/emboj/16.12.3693
    • Jefferies, H. B., Fumagalli, S., Dennis, P. B., Reinhard, C., Pearson, R. B., and, Thomas, G., (1997) Rapamycin suppresses 5′TOP mRNA translation through inhibition of p70s6k. EMBO J. 16, 3693-3704. (Pubitemid 27250062)
    • (1997) EMBO Journal , vol.16 , Issue.12 , pp. 3693-3704
    • Jefferies, H.B.J.1    Fumagalli, S.2    Dennis, P.B.3    Reinhard, C.4    Pearson, R.B.5    Thomas, G.6
  • 18
    • 0033761629 scopus 로고    scopus 로고
    • Synthesis of the translational apparatus is regulated at the translational level
    • Meyuhas, O., (2000) Synthesis of the translational apparatus is regulated at the translational level. Eur. J. Biochem. 267, 6321-6330.
    • (2000) Eur. J. Biochem. , vol.267 , pp. 6321-6330
    • Meyuhas, O.1
  • 19
    • 33745150462 scopus 로고    scopus 로고
    • Ribosomal protein S6 phosphorylation: from protein synthesis to cell size
    • DOI 10.1016/j.tibs.2006.04.003, PII S0968000406001137
    • Ruvinsky, I., and, Meyuhas, O., (2006) Ribosomal protein S6 phosphorylation: from protein synthesis to cell size. Trends Biochem. Sci. 31, 342-348. (Pubitemid 43903237)
    • (2006) Trends in Biochemical Sciences , vol.31 , Issue.6 , pp. 342-348
    • Ruvinsky, I.1    Meyuhas, O.2
  • 20
    • 0032538890 scopus 로고    scopus 로고
    • Disruption of the p705(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase
    • Shima, H., Pende, M., Chen, Y., Fumagalli, S., Thomas, G., and, Kozma, S. C., (1998) Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J. 17, 6649-6659. (Pubitemid 28521798)
    • (1998) EMBO Journal , vol.17 , Issue.22 , pp. 6649-6659
    • Shima, H.1    Pende, M.2    Chen, Y.3    Fumagalli, S.4    Thomas, G.5    Kozma, S.C.6
  • 22
  • 23
    • 0034624043 scopus 로고    scopus 로고
    • s6k and down-regulation of c-Myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen
    • DOI 10.1074/jbc.M005545200
    • Law, B. K., Waltner-Law, M. E., Entingh, A. J., Chytil, A., Aakre, M. E., Norgaard, P., and, Moses, H. L., (2000) Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen. J. Biol. Chem. 275, 38261-38267. (Pubitemid 32009146)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.49 , pp. 38261-38267
    • Law, B.K.1    Waltner-Law, M.E.2    Entingh, A.J.3    Chytil, A.4    Aakre, M.E.5    Norgaard, P.6    Moses, H.L.7
  • 25
    • 43749110929 scopus 로고    scopus 로고
    • Suppression of programmed cell death 4 (PDCD4) protein expression by BCR-ABL-regulated engagement of the mTOR/p70 S6 kinase pathway
    • Carayol, N., Katsoulidis, E., Sassano, A., Altman, J. K., Druker, B. J., and, Platanias, L. C., (2008) Suppression of programmed cell death 4 (PDCD4) protein expression by BCR-ABL-regulated engagement of the mTOR/p70 S6 kinase pathway. J. Biol. Chem. 283, 8601-8610.
    • (2008) J. Biol. Chem. , vol.283 , pp. 8601-8610
    • Carayol, N.1    Katsoulidis, E.2    Sassano, A.3    Altman, J.K.4    Druker, B.J.5    Platanias, L.C.6
  • 26
    • 0034107580 scopus 로고    scopus 로고
    • Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple rapamycin-sensitive steps
    • Wang, L., Wang, X., and, Proud, C. G., (2000) Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple rapamycin-sensitive steps. Am. J. Physiol. Heart Circ. Physiol. 278, H1056-H1068. (Pubitemid 30235480)
    • (2000) American Journal of Physiology - Heart and Circulatory Physiology , vol.278 , Issue.4
    • Wang, L.1    Wang, X.2    Proud, C.G.3
  • 27
    • 41949101770 scopus 로고    scopus 로고
    • SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs
    • DOI 10.1016/j.cell.2008.02.031, PII S0092867408002821
    • Ma, X. M., Yoon, S. O., Richardson, C. J., Julich, K., and, Blenis, J., (2008) SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell 133, 303-313. (Pubitemid 351508301)
    • (2008) Cell , vol.133 , Issue.2 , pp. 303-313
    • Ma, X.M.1    Yoon, S.-O.2    Richardson, C.J.3    Julich, K.4    Blenis, J.5
  • 28
    • 0242637318 scopus 로고    scopus 로고
    • MTOR-Dependent Regulation of Ribosomal Gene Transcription Requires S6K1 and Is Mediated by Phosphorylation of the Carboxy-Terminal Activation Domain of the Nucleolar Transcription Factor UBF
    • DOI 10.1128/MCB.23.23.8862-8877.2003
    • Hannan, K. M., Brandenburger, Y., Jenkins, A., Sharkey, K., Cavanaugh, A., Rothblum, L., Moss, T., Poortinga, G., Mcarthur, G. A., Pearson, R. B., and, Hannan, R. D., (2003) mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. Mol. Cell. Biol. 23, 8862-8877. (Pubitemid 37433385)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.23 , pp. 8862-8877
    • Hannan, K.M.1    Brandenburger, Y.2    Jenkins, A.3    Sharkey, K.4    Cavanaugh, A.5    Rothblum, L.6    Moss, T.7    Poortinga, G.8    McArthur, G.A.9    Pearson, R.B.10    Hannan, R.D.11
  • 29
    • 33749431713 scopus 로고    scopus 로고
    • The mTOR pathway in the control of protein synthesis
    • DOI 10.1152/physiol.00024.2006
    • Wang, X., and, Proud, C. G., (2006) The mTOR pathway in the control of protein synthesis. Physiology (Bethesda) 21, 362-369. (Pubitemid 44511764)
    • (2006) Physiology , vol.21 , Issue.5 , pp. 362-369
    • Wang, X.1    Proud, C.G.2
  • 30
    • 77951911260 scopus 로고    scopus 로고
    • Coordinated control of the gene expression machinery
    • White, R. J., and, Sharrocks, A. D., (2010) Coordinated control of the gene expression machinery. Trends Genet. 26, 214-220.
    • (2010) Trends Genet. , vol.26 , pp. 214-220
    • White, R.J.1    Sharrocks, A.D.2
  • 31
    • 77955287244 scopus 로고    scopus 로고
    • MTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1
    • Kantidakis, T., Ramsbottom, B. A., Birch, J. L., Dowding, S. N., and, White, R. J., (2010) mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1. Proc. Natl. Acad. Sci. USA 107, 11823-11828.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 11823-11828
    • Kantidakis, T.1    Ramsbottom, B.A.2    Birch, J.L.3    Dowding, S.N.4    White, R.J.5
  • 32
    • 33846549173 scopus 로고    scopus 로고
    • A housekeeper with power of attorney: The rRNA genes in ribosome biogenesis
    • DOI 10.1007/s00018-006-6278-1
    • Moss, T., Langlois, F., Gagnon-Kugler, T., and, Stefanovsky, V., (2007) A housekeeper with power of attorney: the rRNA genes in ribosome biogenesis. Cell. Mol. Life Sci. 64, 29-49. (Pubitemid 46159444)
    • (2007) Cellular and Molecular Life Sciences , vol.64 , Issue.1 , pp. 29-49
    • Moss, T.1    Langlois, F.2    Gagnon-Kugler, T.3    Stefanovsky, V.4
  • 33
    • 50849087976 scopus 로고    scopus 로고
    • The splice variants of UBF differentially regulate RNA polymerase i transcription elongation in response to ERK phosphorylation
    • Stefanovsky, V. Y., and, Moss, T., (2008) The splice variants of UBF differentially regulate RNA polymerase I transcription elongation in response to ERK phosphorylation. Nucleic Acids Res. 36, 5093-6101.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 5093-6101
    • Stefanovsky, V.Y.1    Moss, T.2
  • 34
    • 54849406775 scopus 로고    scopus 로고
    • Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer
    • Dai, M. S., and, Lu, H., (2008) Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer. J. Cell. Biochem. 105, 670-677.
    • (2008) J. Cell. Biochem. , vol.105 , pp. 670-677
    • Dai, M.S.1    Lu, H.2
  • 35
    • 2342564500 scopus 로고    scopus 로고
    • An essential role for protein synthesis in oncogenic cellular transformation
    • DOI 10.1038/sj.onc.1207550
    • Bader, A. G., and, Vogt, P. K., (2004) An essential role for protein synthesis in oncogenic cellular transformation. Oncogene 23, 3145-3150. (Pubitemid 38638826)
    • (2004) Oncogene , vol.23 , Issue.18 , pp. 3145-3150
    • Bader, A.G.1    Vogt, P.K.2
  • 36
    • 79551632876 scopus 로고    scopus 로고
    • Protein kinase signaling networks in cancer
    • Brognard, J., and, Hunter, T., (2011) Protein kinase signaling networks in cancer. Curr. Opin. Genet. Dev., 21, 4-11.
    • (2011) Curr. Opin. Genet. Dev. , vol.21 , pp. 4-11
    • Brognard, J.1    Hunter, T.2
  • 37
    • 79955603839 scopus 로고    scopus 로고
    • C-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol i availability during granulocyte differentiation
    • Accessed 28 Dec 2010, [Epub ahead of print]
    • Poortinga, G., Wall, M., Sanij, E., Siwicki, K., Ellul, J., Brown, D., Holloway, T., Hannan, R., Mcarthur, G., c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation. Nucleic Acids Res., Accessed 28 Dec 2010, [Epub ahead of print].
    • Nucleic Acids Res.
    • Poortinga, G.1    Wall, M.2    Sanij, E.3    Siwicki, K.4    Ellul, J.5    Brown, D.6    Holloway, T.7    Hannan, R.8    McArthur, G.9
  • 39
    • 0034252226 scopus 로고    scopus 로고
    • TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p
    • Bodem, J., Dobreva, G., Hoffmann-Rohrer, U., Iben, S., Zentgraf, H., Delius, H., Vingron, M., and, Grummt, I., (2000) TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p. EMBO Rep. 1, 171-175.
    • (2000) EMBO Rep. , vol.1 , pp. 171-175
    • Bodem, J.1    Dobreva, G.2    Hoffmann-Rohrer, U.3    Iben, S.4    Zentgraf, H.5    Delius, H.6    Vingron, M.7    Grummt, I.8
  • 40
    • 73449096759 scopus 로고    scopus 로고
    • The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin
    • Sanij, E., and, Hannan, R. D., (2009) The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin. Epigenetics 4, 374-382.
    • (2009) Epigenetics , vol.4 , pp. 374-382
    • Sanij, E.1    Hannan, R.D.2
  • 42
    • 0037291736 scopus 로고    scopus 로고
    • ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth
    • DOI 10.1016/S1097-2765(03)00036-4
    • Zhao, J., Yuan, X., Frodin, M., and, Grummt, I., (2003) ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. Mol. Cell. 11, 405-413. (Pubitemid 36293834)
    • (2003) Molecular Cell , vol.11 , Issue.2 , pp. 405-413
    • Zhao, J.1    Yuan, X.2    Frodin, M.3    Grummt, I.4
  • 43
    • 55249084500 scopus 로고    scopus 로고
    • Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation
    • Wall, M., Poortinga, G., Hannan, K. M., Pearson, R. B., Hannan, R. D., and, Mcarthur, G. A., (2008) Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation. Blood 112, 2305-2317.
    • (2008) Blood , vol.112 , pp. 2305-2317
    • Wall, M.1    Poortinga, G.2    Hannan, K.M.3    Pearson, R.B.4    Hannan, R.D.5    McArthur, G.A.6
  • 44
    • 56649105133 scopus 로고    scopus 로고
    • RNA polymerases i and III, non-coding RNAs and cancer
    • White, R. J., (2008) RNA polymerases I and III, non-coding RNAs and cancer. Trends Genet. 24, 622-629.
    • (2008) Trends Genet. , vol.24 , pp. 622-629
    • White, R.J.1
  • 45
    • 77949920493 scopus 로고    scopus 로고
    • MYC as a regulator of ribosome biogenesis and protein synthesis
    • Van Riggelen, J., Yetil, A., and, Felsher, D. W., (2010) MYC as a regulator of ribosome biogenesis and protein synthesis. Nat. Rev. Cancer 10, 301-309.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 301-309
    • Van Riggelen, J.1    Yetil, A.2    Felsher, D.W.3
  • 48
    • 71549120380 scopus 로고    scopus 로고
    • The role of Myc-induced protein synthesis in cancer
    • Ruggero, D., (2009) The role of Myc-induced protein synthesis in cancer. Cancer Res. 69, 8839-8843.
    • (2009) Cancer Res. , vol.69 , pp. 8839-8843
    • Ruggero, D.1
  • 49
    • 76749088358 scopus 로고    scopus 로고
    • Pathological roles of MAPK signaling pathways in human diseases
    • Kim, E. K., and, Choi, E. J., (2010) Pathological roles of MAPK signaling pathways in human diseases. Biochim. Biophys. Acta 1802, 369-405.
    • (2010) Biochim. Biophys. Acta , vol.1802 , pp. 369-405
    • Kim, E.K.1    Choi, E.J.2
  • 51
    • 26444618638 scopus 로고    scopus 로고
    • PIK3CA mutations in ovarian cancer
    • author reply 7042- 7043
    • Campbell, I. G., Russell, S. E., and, Phillips, W. A., (2005) PIK3CA mutations in ovarian cancer. Clin. Cancer Res. 11 (19 Pt 1), 7042; author reply 7042- 7043.
    • (2005) Clin. Cancer Res. , vol.11 , Issue.19 PART 1 , pp. 7042
    • Campbell, I.G.1    Russell, S.E.2    Phillips, W.A.3
  • 52
    • 78650234994 scopus 로고    scopus 로고
    • Ras mutational status is a biomarker for resistance to EGFR inhibitors in colorectal carcinoma
    • Dempke, W. C., and, Heinemann, V., (2010) Ras mutational status is a biomarker for resistance to EGFR inhibitors in colorectal carcinoma. Anticancer Res. 30, 4673-4677.
    • (2010) Anticancer Res. , vol.30 , pp. 4673-4677
    • Dempke, W.C.1    Heinemann, V.2
  • 54
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman, J. A., (2009) Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat. Rev. Cancer 9, 550-562.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 57
    • 70349939382 scopus 로고    scopus 로고
    • Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer
    • Siena, S., Sartore-Bianchi, A., Di Nicolantonio, F., Balfour, J., and, Bardelli, A., (2009) Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer. J. Natl. Cancer Inst. 101, 1308-1324.
    • (2009) J. Natl. Cancer Inst. , vol.101 , pp. 1308-1324
    • Siena, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3    Balfour, J.4    Bardelli, A.5
  • 59
    • 77949495196 scopus 로고    scopus 로고
    • The RNA polymerase i transcription machinery: An emerging target for the treatment of cancer
    • Drygin, D., Rice, W. G., and, Grummt, I., (2010) The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer. Annu. Rev. Pharmacol. Toxicol. 50, 131-156.
    • (2010) Annu. Rev. Pharmacol. Toxicol. , vol.50 , pp. 131-156
    • Drygin, D.1    Rice, W.G.2    Grummt, I.3
  • 62
    • 77951431225 scopus 로고    scopus 로고
    • Ribosomopathies: Human disorders of ribosome dysfunction
    • Narla, A., and, Ebert, B. L., (2010) Ribosomopathies: human disorders of ribosome dysfunction. Blood 115, 3196-3205.
    • (2010) Blood , vol.115 , pp. 3196-3205
    • Narla, A.1    Ebert, B.L.2
  • 63
    • 77649098172 scopus 로고    scopus 로고
    • A novel initiation codon mutation in the ribosomal protein S17 gene (RPS17) in a patient with Diamond-Blackfan anemia
    • Song, M. J., Yoo, E. H., Lee, K. O., Kim, G. N., Kim, H. J., Kim, S. Y., and, Kim, S. H., (2010) A novel initiation codon mutation in the ribosomal protein S17 gene (RPS17) in a patient with Diamond-Blackfan anemia. Pediatr. Blood Cancer 54, 629-631.
    • (2010) Pediatr. Blood Cancer , vol.54 , pp. 629-631
    • Song, M.J.1    Yoo, E.H.2    Lee, K.O.3    Kim, G.N.4    Kim, H.J.5    Kim, S.Y.6    Kim, S.H.7
  • 65
    • 75749129362 scopus 로고    scopus 로고
    • The rise of a ribosomopathy and increased cancer risk
    • Luft, F., (2010) The rise of a ribosomopathy and increased cancer risk. J. Mol. Med. 88, 1-3.
    • (2010) J. Mol. Med. , vol.88 , pp. 1-3
    • Luft, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.