Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth

Cancer Research

Volumn 71, Issue 4, 2011, Pages 1418-1430

  Drygin, Denis ^a   Lin, Amy ^a   Bliesath, Josh ^a   Ho, Caroline B ^a   O'Brien, Sean E ^a   Proffitt, Chris ^a   Omori, Mayuko ^a   Haddach, Mustapha ^a   Schwaebe, Michael K ^a   Siddiqui Jain, Adam ^a   Streiner, Nicole ^a   Quin, Jaclyn E ^b   Sanij, Elaine ^b   Bywater, Megan J ^b   Hannan, Ross D ^b,c   Ryckman, David ^a   Anderes, Kenna ^a   Rice, William G ^a  

^a Cylene Pharmaceuticals   (United States)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CX 5461; DNA DIRECTED RNA POLYMERASE; DNA DIRECTED RNA POLYMERASE I; PROTEIN P53; RIBOSOME RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHAGY; CANCER CELL; CLINICAL TRIAL; CONTROLLED STUDY; DNA REPLICATION; DNA TRANSCRIPTION; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG TARGETING; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA SYNTHESIS; SENESCENCE; SOLID TUMOR; TUMOR GROWTH; TUMOR XENOGRAFT;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; BENZOTHIAZOLES; CELL PROLIFERATION; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HELA CELLS; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MOLECULAR TARGETED THERAPY; NAPHTHYRIDINES; NEOPLASMS; RNA POLYMERASE I; RNA, RIBOSOMAL; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79951847459     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-1728     Document Type: Article

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