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Volumn 36, Issue , 2014, Pages 113-120

MTORC1 signaling controls multiple steps in ribosome biogenesis

Author keywords

5' TOP; Mammalian target of rapamycin; MTOR; MTOR complex 1; Rapamycin; Ribosomal protein; RNA polymerase; RRNA

Indexed keywords

DNA DIRECTED RNA POLYMERASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; RIBOSOME DNA; RNA 5S; RNA POLYMERASE II; DNA DIRECTED RNA POLYMERASE III; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; RIBOSOME PROTEIN; RIBOSOME RNA; TARGET OF RAPAMYCIN KINASE;

EID: 84912533536     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2014.08.004     Document Type: Review
Times cited : (194)

References (94)
  • 1
    • 0003288676 scopus 로고
    • Beitraege zur Histologie und Aetiologie der Carconoms
    • Pianese G. Beitraege zur Histologie und Aetiologie der Carconoms. Beitr Pathol Anat Allgem Pathol 1896, 142:1-193.
    • (1896) Beitr Pathol Anat Allgem Pathol , vol.142 , pp. 1-193
    • Pianese, G.1
  • 2
    • 0347716759 scopus 로고    scopus 로고
    • Rheb fills a GAP between TSC and TOR
    • Manning B.D., Cantley L.C. Rheb fills a GAP between TSC and TOR. Trends Biochem Sci 2003, 28:573-576.
    • (2003) Trends Biochem Sci , vol.28 , pp. 573-576
    • Manning, B.D.1    Cantley, L.C.2
  • 3
    • 78650943298 scopus 로고    scopus 로고
    • ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1)
    • Carriere A., Romeo Y., costa-Jaquez H.A., Moreau J., Bonneil E., Thibault P., et al. ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1). J Biol Chem 2011, 286:567-577.
    • (2011) J Biol Chem , vol.286 , pp. 567-577
    • Carriere, A.1    Romeo, Y.2    costa-Jaquez, H.A.3    Moreau, J.4    Bonneil, E.5    Thibault, P.6
  • 4
    • 4544384577 scopus 로고    scopus 로고
    • Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
    • Roux P.P., Ballif B.A., Anjum R., Gygi S.P., Blenis J. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci USA 2004, 101:13489-13494.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13489-13494
    • Roux, P.P.1    Ballif, B.A.2    Anjum, R.3    Gygi, S.P.4    Blenis, J.5
  • 5
    • 79961011264 scopus 로고    scopus 로고
    • Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90RSK in the control of mTORC1 protein signaling by phorbol esters
    • Fonseca B.D., Alain T., Finestone L.K., Huang B.P., Rolfe M., Jiang T., et al. Pharmacological and genetic evaluation of proposed roles of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), extracellular signal-regulated kinase (ERK), and p90RSK in the control of mTORC1 protein signaling by phorbol esters. J Biol Chem 2011, 286:27111-27122.
    • (2011) J Biol Chem , vol.286 , pp. 27111-27122
    • Fonseca, B.D.1    Alain, T.2    Finestone, L.K.3    Huang, B.P.4    Rolfe, M.5    Jiang, T.6
  • 6
    • 84884676252 scopus 로고    scopus 로고
    • Nutrient signaling to mTOR and cell growth
    • Jewell J.L., Guan K.L. Nutrient signaling to mTOR and cell growth. Trends Biochem Sci 2013, 38:233-242.
    • (2013) Trends Biochem Sci , vol.38 , pp. 233-242
    • Jewell, J.L.1    Guan, K.L.2
  • 7
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Sancak Y., Bar-Peled L., Zoncu R., Markhard A.L., Nada S., Sabatini D.M. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010, 141:290-303.
    • (2010) Cell , vol.141 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3    Markhard, A.L.4    Nada, S.5    Sabatini, D.M.6
  • 8
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K., Zhu T., Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115:577-590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 9
    • 33748153690 scopus 로고    scopus 로고
    • TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
    • Inoki K., Ouyang H., Zhu T., Lindvall C., Wang Y., Zhang X., et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 2006, 126:955-968.
    • (2006) Cell , vol.126 , pp. 955-968
    • Inoki, K.1    Ouyang, H.2    Zhu, T.3    Lindvall, C.4    Wang, Y.5    Zhang, X.6
  • 10
    • 78650239404 scopus 로고    scopus 로고
    • Functions and regulation of the 70kDa ribosomal S6 kinases
    • Fenton T.R., Gout I.T. Functions and regulation of the 70kDa ribosomal S6 kinases. Int J Biochem Cell Biol 2011, 43:47-59.
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 47-59
    • Fenton, T.R.1    Gout, I.T.2
  • 12
    • 0032834055 scopus 로고    scopus 로고
    • EIF4 translation factors: effectors of mRNA recruitment to ribosomes and regulators of translation
    • Gingras A-C., Raught B., Sonenberg N. eIF4 translation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 1999, 68:913-963.
    • (1999) Annu Rev Biochem , vol.68 , pp. 913-963
    • Gingras, A.-C.1    Raught, B.2    Sonenberg, N.3
  • 13
    • 0037718389 scopus 로고    scopus 로고
    • TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
    • Schalm S.S., Fingar D.C., Sabatini D.M., Blenis J. TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr Biol 2003, 13:797-806.
    • (2003) Curr Biol , vol.13 , pp. 797-806
    • Schalm, S.S.1    Fingar, D.C.2    Sabatini, D.M.3    Blenis, J.4
  • 14
    • 0037117409 scopus 로고    scopus 로고
    • Identification of a conserved motif required for mTOR signaling
    • Schalm S.S., Blenis J. Identification of a conserved motif required for mTOR signaling. Curr Biol 2002, 12:632-639.
    • (2002) Curr Biol , vol.12 , pp. 632-639
    • Schalm, S.S.1    Blenis, J.2
  • 15
    • 84876816592 scopus 로고    scopus 로고
    • Quality control mechanisms during ribosome maturation
    • Karbstein K. Quality control mechanisms during ribosome maturation. Trends Cell Biol 2013, 23:242-250.
    • (2013) Trends Cell Biol , vol.23 , pp. 242-250
    • Karbstein, K.1
  • 16
    • 79952293503 scopus 로고    scopus 로고
    • Activation of mTORC2 by association with the ribosome
    • Zinzalla V., Stracka D., Oppliger W., Hall M.N. Activation of mTORC2 by association with the ribosome. Cell 2011, 144:757-768.
    • (2011) Cell , vol.144 , pp. 757-768
    • Zinzalla, V.1    Stracka, D.2    Oppliger, W.3    Hall, M.N.4
  • 17
    • 78649712949 scopus 로고    scopus 로고
    • MTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
    • Oh W.J., Wu C.C., Kim S.J., Facchinetti V., Julien L.A., Finlan M., et al. mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J 2010, 29:3939-3951.
    • (2010) EMBO J , vol.29 , pp. 3939-3951
    • Oh, W.J.1    Wu, C.C.2    Kim, S.J.3    Facchinetti, V.4    Julien, L.A.5    Finlan, M.6
  • 18
    • 84900468373 scopus 로고    scopus 로고
    • The many faces of small nucleolar RNAs
    • Bratkovic T., Rogelj B. The many faces of small nucleolar RNAs. Biochim Biophys Acta 2014, 1839:438-443.
    • (2014) Biochim Biophys Acta , vol.1839 , pp. 438-443
    • Bratkovic, T.1    Rogelj, B.2
  • 19
    • 50649096622 scopus 로고    scopus 로고
    • The role of human ribosomal proteins in the maturation of rRNA and ribosome production
    • Robledo S., Idol R.A., Crimmins D.L., Ladenson J.H., Mason P.J., Bessler M. The role of human ribosomal proteins in the maturation of rRNA and ribosome production. RNA 2008, 14:1918-1929.
    • (2008) RNA , vol.14 , pp. 1918-1929
    • Robledo, S.1    Idol, R.A.2    Crimmins, D.L.3    Ladenson, J.H.4    Mason, P.J.5    Bessler, M.6
  • 20
    • 30544439063 scopus 로고    scopus 로고
    • Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cells
    • Rouquette J., Choesmel V., Gleizes P.E. Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cells. EMBO J 2005, 24:2862-2872.
    • (2005) EMBO J , vol.24 , pp. 2862-2872
    • Rouquette, J.1    Choesmel, V.2    Gleizes, P.E.3
  • 21
    • 0032915417 scopus 로고    scopus 로고
    • Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae
    • Powers T., Walter P. Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae. Mol Biol Cell 1999, 10:987-1000.
    • (1999) Mol Biol Cell , vol.10 , pp. 987-1000
    • Powers, T.1    Walter, P.2
  • 22
    • 84859366546 scopus 로고    scopus 로고
    • MTOR signaling regulates the processing of pre-rRNA in human cells
    • Iadevaia V., Zhang Z., Jan E., Proud C.G. mTOR signaling regulates the processing of pre-rRNA in human cells. Nucleic Acids Res 2012, 40:2527-2539.
    • (2012) Nucleic Acids Res , vol.40 , pp. 2527-2539
    • Iadevaia, V.1    Zhang, Z.2    Jan, E.3    Proud, C.G.4
  • 23
    • 84896629473 scopus 로고    scopus 로고
    • Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program
    • Chauvin C., Koka V., Nouschi A., Mieulet V., Hoareau-Aveilla C., Dreazen A., et al. Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program. Oncogene 2013, 33:474-483.
    • (2013) Oncogene , vol.33 , pp. 474-483
    • Chauvin, C.1    Koka, V.2    Nouschi, A.3    Mieulet, V.4    Hoareau-Aveilla, C.5    Dreazen, A.6
  • 24
    • 24944464482 scopus 로고    scopus 로고
    • Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis
    • Ruvinsky I., Sharon N., Lerer T., Cohen H., Stolovich-Rain M., Nir T., et al. Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev 2005, 19:2199-2211.
    • (2005) Genes Dev , vol.19 , pp. 2199-2211
    • Ruvinsky, I.1    Sharon, N.2    Lerer, T.3    Cohen, H.4    Stolovich-Rain, M.5    Nir, T.6
  • 25
    • 34248174923 scopus 로고    scopus 로고
    • Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit
    • Rohrmoser M., Holzel M., Grimm T., Malamoussi A., Harasim T., Orban M., et al. Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. Mol Cell Biol 2007, 27:3682-3694.
    • (2007) Mol Cell Biol , vol.27 , pp. 3682-3694
    • Rohrmoser, M.1    Holzel, M.2    Grimm, T.3    Malamoussi, A.4    Harasim, T.5    Orban, M.6
  • 26
    • 23744467924 scopus 로고    scopus 로고
    • Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation
    • Holzel M., Rohrmoser M., Schlee M., Grimm T., Harasim T., Malamoussi A., et al. Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. J Cell Biol 2005, 170:367-378.
    • (2005) J Cell Biol , vol.170 , pp. 367-378
    • Holzel, M.1    Rohrmoser, M.2    Schlee, M.3    Grimm, T.4    Harasim, T.5    Malamoussi, A.6
  • 27
    • 3042724637 scopus 로고    scopus 로고
    • Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis
    • Lapik Y.R., Fernandes C.J., Lau L.F., Pestov D.G. Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis. Mol Cell 2004, 15:17-29.
    • (2004) Mol Cell , vol.15 , pp. 17-29
    • Lapik, Y.R.1    Fernandes, C.J.2    Lau, L.F.3    Pestov, D.G.4
  • 28
    • 0037119468 scopus 로고    scopus 로고
    • Functional inactivation of the mouse nucleolar protein Bop1 inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression
    • Strezoska Z., Pestov D.G., Lau L.F. Functional inactivation of the mouse nucleolar protein Bop1 inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression. J Biol Chem 2002, 277:29617-29625.
    • (2002) J Biol Chem , vol.277 , pp. 29617-29625
    • Strezoska, Z.1    Pestov, D.G.2    Lau, L.F.3
  • 29
    • 0033912841 scopus 로고    scopus 로고
    • Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and 5. 8S RRNA processing and 60S ribosome biogenesis
    • Strezoska Z., Pestov D.G., Lau L.F. Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and 5. 8S RRNA processing and 60S ribosome biogenesis. Mol Cell Biol 2000, 20:5516-5528.
    • (2000) Mol Cell Biol , vol.20 , pp. 5516-5528
    • Strezoska, Z.1    Pestov, D.G.2    Lau, L.F.3
  • 30
    • 33750044901 scopus 로고    scopus 로고
    • Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases
    • Mayer C., Grummt I. Ribosome biogenesis and cell growth: mTOR coordinates transcription by all three classes of nuclear RNA polymerases. Oncogene 2006, 25:6384-6391.
    • (2006) Oncogene , vol.25 , pp. 6384-6391
    • Mayer, C.1    Grummt, I.2
  • 31
    • 10344222155 scopus 로고    scopus 로고
    • How cells coordinate growth and division
    • Jorgensen P., Tyers M. How cells coordinate growth and division. Curr Biol 2004, 14:R1014-R1027.
    • (2004) Curr Biol , vol.14 , pp. R1014-R1027
    • Jorgensen, P.1    Tyers, M.2
  • 33
    • 0017231359 scopus 로고
    • Amino acid starvation affects the initiation frequency of nucleolar RNA polymerase
    • Grummt I., Smith V.A., Grummt F. Amino acid starvation affects the initiation frequency of nucleolar RNA polymerase. Cell 1976, 7:439-445.
    • (1976) Cell , vol.7 , pp. 439-445
    • Grummt, I.1    Smith, V.A.2    Grummt, F.3
  • 34
    • 0027931137 scopus 로고
    • Modulation of transcription of rRNA genes by rapamycin
    • Mahajan P.B. Modulation of transcription of rRNA genes by rapamycin. Int J Immunopharmacol 1994, 16:711-721.
    • (1994) Int J Immunopharmacol , vol.16 , pp. 711-721
    • Mahajan, P.B.1
  • 35
    • 33748298941 scopus 로고    scopus 로고
    • Nutrient regulates Tor1 nuclear localization and association with rDNA promoter
    • Li H., Tsang C.K., Watkins M., Bertram P.G., Zheng X.F. Nutrient regulates Tor1 nuclear localization and association with rDNA promoter. Nature 2006, 442:1058-1061.
    • (2006) Nature , vol.442 , pp. 1058-1061
    • Li, H.1    Tsang, C.K.2    Watkins, M.3    Bertram, P.G.4    Zheng, X.F.5
  • 36
    • 77953512889 scopus 로고    scopus 로고
    • MTOR binds to the promoters of RNA polymerase I- and III-transcribed genes
    • Tsang C.K., Liu H., Zheng X.F. mTOR binds to the promoters of RNA polymerase I- and III-transcribed genes. Cell Cycle 2010, 9:953-957.
    • (2010) Cell Cycle , vol.9 , pp. 953-957
    • Tsang, C.K.1    Liu, H.2    Zheng, X.F.3
  • 37
    • 84875843747 scopus 로고    scopus 로고
    • Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes
    • Goodfellow S.J., Zomerdijk J.C. Basic mechanisms in RNA polymerase I transcription of the ribosomal RNA genes. Subcell Biochem 2013, 61:211-236.
    • (2013) Subcell Biochem , vol.61 , pp. 211-236
    • Goodfellow, S.J.1    Zomerdijk, J.C.2
  • 38
    • 0027130985 scopus 로고
    • Transcription from the rat 45S ribosomal DNA promoter does not require the factor UBF
    • Smith S.D., O'Mahony D.J., Kinsella B.T., Rothblum L.I. Transcription from the rat 45S ribosomal DNA promoter does not require the factor UBF. Gene Expr 1993, 3:229-236.
    • (1993) Gene Expr , vol.3 , pp. 229-236
    • Smith, S.D.1    O'Mahony, D.J.2    Kinsella, B.T.3    Rothblum, L.I.4
  • 39
    • 33746517313 scopus 로고    scopus 로고
    • UBF activates RNA polymerase I transcription by stimulating promoter escape
    • Panov K.I., Friedrich J.K., Russell J., Zomerdijk J.C. UBF activates RNA polymerase I transcription by stimulating promoter escape. EMBO J 2006, 25:3310-3322.
    • (2006) EMBO J , vol.25 , pp. 3310-3322
    • Panov, K.I.1    Friedrich, J.K.2    Russell, J.3    Zomerdijk, J.C.4
  • 40
    • 0028839872 scopus 로고
    • Coactivator and promoter-selective properties of RNA polymerase I TAFs
    • Beckmann H., Chen J.L., O'Brien T., Tjian R. Coactivator and promoter-selective properties of RNA polymerase I TAFs. Science 1995, 270:1506-1509.
    • (1995) Science , vol.270 , pp. 1506-1509
    • Beckmann, H.1    Chen, J.L.2    O'Brien, T.3    Tjian, R.4
  • 41
    • 0030061161 scopus 로고    scopus 로고
    • The species-specific RNA polymerase I transcription factor SL-1 binds to upstream binding factor
    • Hempel W.M., Cavanaugh A.H., Hannan R.D., Taylor L., Rothblum L.I. The species-specific RNA polymerase I transcription factor SL-1 binds to upstream binding factor. Mol Cell Biol 1996, 16:557-563.
    • (1996) Mol Cell Biol , vol.16 , pp. 557-563
    • Hempel, W.M.1    Cavanaugh, A.H.2    Hannan, R.D.3    Taylor, L.4    Rothblum, L.I.5
  • 42
    • 73449096759 scopus 로고    scopus 로고
    • The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin
    • Sanij E., Hannan R.D. The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin. Epigenetics 2009, 4:374-382.
    • (2009) Epigenetics , vol.4 , pp. 374-382
    • Sanij, E.1    Hannan, R.D.2
  • 43
    • 0242637318 scopus 로고    scopus 로고
    • MTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF
    • Hannan K.M., Brandenburger Y., Jenkins A., Sharkey K., Cavanaugh A., Rothblum L., et al. mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. Mol Cell Biol 2003, 23:8862-8877.
    • (2003) Mol Cell Biol , vol.23 , pp. 8862-8877
    • Hannan, K.M.1    Brandenburger, Y.2    Jenkins, A.3    Sharkey, K.4    Cavanaugh, A.5    Rothblum, L.6
  • 44
    • 0032936298 scopus 로고    scopus 로고
    • Recruitment of TATA-binding protein-TAFI complex SL1 to the human ribosomal DNA promoter is mediated by the carboxy-terminal activation domain of upstream binding factor (UBF) and is regulated by UBF phosphorylation
    • Tuan J.C., Zhai W., Comai L. Recruitment of TATA-binding protein-TAFI complex SL1 to the human ribosomal DNA promoter is mediated by the carboxy-terminal activation domain of upstream binding factor (UBF) and is regulated by UBF phosphorylation. Mol Cell Biol 1999, 19:2872-2879.
    • (1999) Mol Cell Biol , vol.19 , pp. 2872-2879
    • Tuan, J.C.1    Zhai, W.2    Comai, L.3
  • 45
    • 0026591023 scopus 로고
    • The nucleolar transcription factor mUBF is phosphorylated by casein kinase II in the C-terminal hyperacidic tail which is essential for transactivation
    • Voit R., Schnapp A., Kuhn A., Rosenbauer H., Hirschmann P., Stunnenberg H.G., et al. The nucleolar transcription factor mUBF is phosphorylated by casein kinase II in the C-terminal hyperacidic tail which is essential for transactivation. EMBO J 1992, 11:2211-2218.
    • (1992) EMBO J , vol.11 , pp. 2211-2218
    • Voit, R.1    Schnapp, A.2    Kuhn, A.3    Rosenbauer, H.4    Hirschmann, P.5    Stunnenberg, H.G.6
  • 46
    • 36048959205 scopus 로고    scopus 로고
    • Hmo1 is required for TOR-dependent regulation of ribosomal protein gene transcription
    • Berger A.B., Decourty L., Badis G., Nehrbass U., Jacquier A., Gadal O. Hmo1 is required for TOR-dependent regulation of ribosomal protein gene transcription. Mol Cell Biol 2007, 27:8015-8026.
    • (2007) Mol Cell Biol , vol.27 , pp. 8015-8026
    • Berger, A.B.1    Decourty, L.2    Badis, G.3    Nehrbass, U.4    Jacquier, A.5    Gadal, O.6
  • 47
    • 80053998078 scopus 로고    scopus 로고
    • Expression of yeast high mobility group protein HMO1 is regulated by TOR signaling
    • Xiao L., Kamau E., Donze D., Grove A. Expression of yeast high mobility group protein HMO1 is regulated by TOR signaling. Gene 2011, 489:55-62.
    • (2011) Gene , vol.489 , pp. 55-62
    • Xiao, L.1    Kamau, E.2    Donze, D.3    Grove, A.4
  • 48
    • 1542305503 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients
    • James M.J., Zomerdijk J.C. Phosphatidylinositol 3-kinase and mTOR signaling pathways regulate RNA polymerase I transcription in response to IGF-1 and nutrients. J Biol Chem 2004, 279:8911-8918.
    • (2004) J Biol Chem , vol.279 , pp. 8911-8918
    • James, M.J.1    Zomerdijk, J.C.2
  • 49
    • 0023651269 scopus 로고
    • Transcription of mouse rDNA is regulated by an activated subform of RNA polymerase I
    • Tower J., Sollner-Webb B. Transcription of mouse rDNA is regulated by an activated subform of RNA polymerase I. Cell 1987, 50:873-883.
    • (1987) Cell , vol.50 , pp. 873-883
    • Tower, J.1    Sollner-Webb, B.2
  • 50
    • 0037291736 scopus 로고    scopus 로고
    • ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth
    • Zhao J., Yuan X., Frodin M., Grummt I. ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth. Mol Cell 2003, 11:405-413.
    • (2003) Mol Cell , vol.11 , pp. 405-413
    • Zhao, J.1    Yuan, X.2    Frodin, M.3    Grummt, I.4
  • 51
    • 1542343973 scopus 로고    scopus 로고
    • MTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability
    • Mayer C., Zhao J., Yuan X., Grummt I. mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes Dev 2004, 18:423-434.
    • (2004) Genes Dev , vol.18 , pp. 423-434
    • Mayer, C.1    Zhao, J.2    Yuan, X.3    Grummt, I.4
  • 52
    • 0742270606 scopus 로고    scopus 로고
    • Tor pathway regulates Rrn3p-dependent recruitment of yeast RNA polymerase I to the promoter but does not participate in alteration of the number of active genes
    • Claypool J.A., French S.L., Johzuka K., Eliason K., Vu L., Dodd J.A., et al. Tor pathway regulates Rrn3p-dependent recruitment of yeast RNA polymerase I to the promoter but does not participate in alteration of the number of active genes. Mol Biol Cell 2004, 15:946-956.
    • (2004) Mol Biol Cell , vol.15 , pp. 946-956
    • Claypool, J.A.1    French, S.L.2    Johzuka, K.3    Eliason, K.4    Vu, L.5    Dodd, J.A.6
  • 53
    • 37249034796 scopus 로고    scopus 로고
    • Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway
    • Grewal S.S., Evans J.R., Edgar B.A. Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway. J Cell Biol 2007, 179:1105-1113.
    • (2007) J Cell Biol , vol.179 , pp. 1105-1113
    • Grewal, S.S.1    Evans, J.R.2    Edgar, B.A.3
  • 54
    • 77952036652 scopus 로고    scopus 로고
    • Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells
    • Shor B., Wu J., Shakey Q., Toral-Barza L., Shi C., Follettie M., et al. Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells. J Biol Chem 2010, 285:15380-15392.
    • (2010) J Biol Chem , vol.285 , pp. 15380-15392
    • Shor, B.1    Wu, J.2    Shakey, Q.3    Toral-Barza, L.4    Shi, C.5    Follettie, M.6
  • 55
    • 77955287244 scopus 로고    scopus 로고
    • MTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1
    • Kantidakis T., Ramsbottom B.A., Birch J.L., Dowding S.N., White R.J. mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1. Proc Natl Acad Sci USA 2010, 107:11823-11828.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 11823-11828
    • Kantidakis, T.1    Ramsbottom, B.A.2    Birch, J.L.3    Dowding, S.N.4    White, R.J.5
  • 56
    • 84875238269 scopus 로고    scopus 로고
    • Regulation of pol III transcription by nutrient and stress signaling pathways
    • Moir R.D., Willis I.M. Regulation of pol III transcription by nutrient and stress signaling pathways. Biochim Biophys Acta 2013, 1829:361-375.
    • (2013) Biochim Biophys Acta , vol.1829 , pp. 361-375
    • Moir, R.D.1    Willis, I.M.2
  • 58
    • 67649827419 scopus 로고    scopus 로고
    • Regulation of RNA polymerase III transcription involves SCH9-dependent and SCH9-independent branches of the target of rapamycin (TOR) pathway
    • Lee J., Moir R.D., Willis I.M. Regulation of RNA polymerase III transcription involves SCH9-dependent and SCH9-independent branches of the target of rapamycin (TOR) pathway. J Biol Chem 2009, 284:12604-12608.
    • (2009) J Biol Chem , vol.284 , pp. 12604-12608
    • Lee, J.1    Moir, R.D.2    Willis, I.M.3
  • 59
    • 69249240179 scopus 로고    scopus 로고
    • Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis
    • Huber A., Bodenmiller B., Uotila A., Stahl M., Wanka S., Gerrits B., et al. Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis. Genes Dev 2009, 23:1929-1943.
    • (2009) Genes Dev , vol.23 , pp. 1929-1943
    • Huber, A.1    Bodenmiller, B.2    Uotila, A.3    Stahl, M.4    Wanka, S.5    Gerrits, B.6
  • 60
    • 68249159982 scopus 로고    scopus 로고
    • Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1
    • Wei Y., Tsang C.K., Zheng X.F. Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1. EMBO J 2009, 28:2220-2230.
    • (2009) EMBO J , vol.28 , pp. 2220-2230
    • Wei, Y.1    Tsang, C.K.2    Zheng, X.F.3
  • 61
    • 1842640418 scopus 로고    scopus 로고
    • Translational regulation of terminal oligopyrimidine mRNAs induced by serum and amino acids involves distinct signaling events
    • Caldarola S., Amaldi F., Proud C.G., Loreni F. Translational regulation of terminal oligopyrimidine mRNAs induced by serum and amino acids involves distinct signaling events. J Biol Chem 2004, 279:13522-13531.
    • (2004) J Biol Chem , vol.279 , pp. 13522-13531
    • Caldarola, S.1    Amaldi, F.2    Proud, C.G.3    Loreni, F.4
  • 62
    • 80053625750 scopus 로고    scopus 로고
    • Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR
    • Damgaard C.K., Lykke-Andersen J. Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR. Genes Dev 2011, 25:2057-2068.
    • (2011) Genes Dev , vol.25 , pp. 2057-2068
    • Damgaard, C.K.1    Lykke-Andersen, J.2
  • 64
    • 0020320668 scopus 로고
    • Regulation of ribosomal protein mRNA content and translation in growth-stimulated mouse fibroblasts
    • Geyer P.K., Meyuhas O., Perry R.P., Johnson L.F. Regulation of ribosomal protein mRNA content and translation in growth-stimulated mouse fibroblasts. Mol Cell Biol 1982, 2:685-693.
    • (1982) Mol Cell Biol , vol.2 , pp. 685-693
    • Geyer, P.K.1    Meyuhas, O.2    Perry, R.P.3    Johnson, L.F.4
  • 65
    • 0028207001 scopus 로고
    • Rapamycin selectively represses translation of the 'polypyrimidine tract' mRNA family
    • Jefferies H.B.J., Reinhard G., Kozma S.C., Thomas G. Rapamycin selectively represses translation of the 'polypyrimidine tract' mRNA family. Proc Natl Acad Sci USA 1994, 91:4441-4445.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4441-4445
    • Jefferies, H.B.J.1    Reinhard, G.2    Kozma, S.C.3    Thomas, G.4
  • 66
    • 84862777192 scopus 로고    scopus 로고
    • The translational landscape of mTOR signalling steers cancer initiation and metastasis
    • Hsieh A.C., Liu Y., Edlind M.P., Ingolia N.T., Janes M.R., Sher A., et al. The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature 2012, 485:55-61.
    • (2012) Nature , vol.485 , pp. 55-61
    • Hsieh, A.C.1    Liu, Y.2    Edlind, M.P.3    Ingolia, N.T.4    Janes, M.R.5    Sher, A.6
  • 68
    • 0041315722 scopus 로고    scopus 로고
    • La protein is associated with terminal oligopyrimidine mRNAs in actively translating polysomes
    • Cardinali B., Carissimi C., Gravina P., Pierandrei-Amaldi P. La protein is associated with terminal oligopyrimidine mRNAs in actively translating polysomes. J Biol Chem 2003, 278:35145-35151.
    • (2003) J Biol Chem , vol.278 , pp. 35145-35151
    • Cardinali, B.1    Carissimi, C.2    Gravina, P.3    Pierandrei-Amaldi, P.4
  • 69
    • 0031588899 scopus 로고    scopus 로고
    • Cellular nucleic acid binding protein binds a conserved region of the 5' UTR of Xenopus laevis ribosomal protein mRNAs
    • Pellizzoni L., Lotti F., Maras B., Pierandrei-Amaldi P. Cellular nucleic acid binding protein binds a conserved region of the 5' UTR of Xenopus laevis ribosomal protein mRNAs. J Mol Biol 1997, 267:264-275.
    • (1997) J Mol Biol , vol.267 , pp. 264-275
    • Pellizzoni, L.1    Lotti, F.2    Maras, B.3    Pierandrei-Amaldi, P.4
  • 70
    • 84893912480 scopus 로고    scopus 로고
    • Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation
    • Tcherkezian J., Cargnello M., Romeo Y., Huttlin E.L., Lavoie G., Gygi S.P., et al. Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation. Genes Dev 2014, 28:357-371.
    • (2014) Genes Dev , vol.28 , pp. 357-371
    • Tcherkezian, J.1    Cargnello, M.2    Romeo, Y.3    Huttlin, E.L.4    Lavoie, G.5    Gygi, S.P.6
  • 72
    • 11144356304 scopus 로고    scopus 로고
    • S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway
    • Pende M., Um S.H., Mieulet V., Sticker M., Goss V.L., Mestan J., et al. S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol Cell Biol 2004, 24:3112-3124.
    • (2004) Mol Cell Biol , vol.24 , pp. 3112-3124
    • Pende, M.1    Um, S.H.2    Mieulet, V.3    Sticker, M.4    Goss, V.L.5    Mestan, J.6
  • 73
    • 43449090367 scopus 로고    scopus 로고
    • MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation
    • Orom U.A., Nielsen F.C., Lund A.H. MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. Mol Cell 2008, 30:460-471.
    • (2008) Mol Cell , vol.30 , pp. 460-471
    • Orom, U.A.1    Nielsen, F.C.2    Lund, A.H.3
  • 74
    • 0029168362 scopus 로고
    • Overexpression of initiation factor eIF-4E does not relieve the translational repression of ribosomal protein mRNAs in quiescent cells
    • Shama S., Avni D., Frederickson R.M., Sonenberg N., Meyuhas O. Overexpression of initiation factor eIF-4E does not relieve the translational repression of ribosomal protein mRNAs in quiescent cells. Gene Expr 1995, 4:241-252.
    • (1995) Gene Expr , vol.4 , pp. 241-252
    • Shama, S.1    Avni, D.2    Frederickson, R.M.3    Sonenberg, N.4    Meyuhas, O.5
  • 75
    • 84860805752 scopus 로고    scopus 로고
    • Stable isotope-labelling analysis of the impact of inhibition of the mammalian target of rapamycin on protein synthesis
    • Huo Y., Iadevaia V., Yao Z., Kelly I., Cosulich S., Guichard S., et al. Stable isotope-labelling analysis of the impact of inhibition of the mammalian target of rapamycin on protein synthesis. Biochem J 2012, 444:141-151.
    • (2012) Biochem J , vol.444 , pp. 141-151
    • Huo, Y.1    Iadevaia, V.2    Yao, Z.3    Kelly, I.4    Cosulich, S.5    Guichard, S.6
  • 76
    • 84901700198 scopus 로고    scopus 로고
    • Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner
    • Miloslavski R., Cohen E., Avraham A., Iluz Y., Hayouka Z., Kasir J., et al. Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner. J Mol Cell Biol 2014, 6:255-266.
    • (2014) J Mol Cell Biol , vol.6 , pp. 255-266
    • Miloslavski, R.1    Cohen, E.2    Avraham, A.3    Iluz, Y.4    Hayouka, Z.5    Kasir, J.6
  • 77
    • 34250755685 scopus 로고    scopus 로고
    • Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation
    • Mamane Y., Petroulakis E., Martineau Y., Sato T.A., Larsson O., Rajasekhar V.K., et al. Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation. PLoS ONE 2007, 2:e242.
    • (2007) PLoS ONE , vol.2 , pp. e242
    • Mamane, Y.1    Petroulakis, E.2    Martineau, Y.3    Sato, T.A.4    Larsson, O.5    Rajasekhar, V.K.6
  • 78
    • 0033773874 scopus 로고    scopus 로고
    • Transcription inhibitors stimulate translation of 5' TOP mRNAs through activation of S6 kinase and the mTOR/FRAP signalling pathway
    • Loreni F., Thomas G., Amaldi F. Transcription inhibitors stimulate translation of 5' TOP mRNAs through activation of S6 kinase and the mTOR/FRAP signalling pathway. Eur J Biochem 2000, 267:6594-6601.
    • (2000) Eur J Biochem , vol.267 , pp. 6594-6601
    • Loreni, F.1    Thomas, G.2    Amaldi, F.3
  • 79
    • 84899853565 scopus 로고    scopus 로고
    • Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors
    • Liu R., Iadevaia V., Averous J., Taylor P.M., Zhang Z., Proud C.G. Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex 1 signalling and downstream translation factors. Nucleic Acids Res 2014, 42:5083-5096.
    • (2014) Nucleic Acids Res , vol.42 , pp. 5083-5096
    • Liu, R.1    Iadevaia, V.2    Averous, J.3    Taylor, P.M.4    Zhang, Z.5    Proud, C.G.6
  • 81
    • 0242721592 scopus 로고    scopus 로고
    • Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway
    • Zhang Y., Wolf G.W., Bhat K., Jin A., Allio T., Burkhart W.A., et al. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol 2003, 23:8902-8912.
    • (2003) Mol Cell Biol , vol.23 , pp. 8902-8912
    • Zhang, Y.1    Wolf, G.W.2    Bhat, K.3    Jin, A.4    Allio, T.5    Burkhart, W.A.6
  • 82
    • 7244238177 scopus 로고    scopus 로고
    • Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5
    • Dai M.S., Lu H. Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5. J Biol Chem 2004, 279:44475-44482.
    • (2004) J Biol Chem , vol.279 , pp. 44475-44482
    • Dai, M.S.1    Lu, H.2
  • 83
    • 84892443134 scopus 로고    scopus 로고
    • 5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint
    • Donati G., Peddigari S., Mercer C.A., Thomas G. 5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint. Cell Rep 2013, 4:87-98.
    • (2013) Cell Rep , vol.4 , pp. 87-98
    • Donati, G.1    Peddigari, S.2    Mercer, C.A.3    Thomas, G.4
  • 85
    • 48449101433 scopus 로고    scopus 로고
    • P53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling
    • Budanov A.V., Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell 2008, 134:451-460.
    • (2008) Cell , vol.134 , pp. 451-460
    • Budanov, A.V.1    Karin, M.2
  • 86
    • 34248194200 scopus 로고    scopus 로고
    • The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
    • Feng Z., Hu W., de S.E., Teresky A.K., Jin S., Lowe S., et al. The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res 2007, 67:3043-3053.
    • (2007) Cancer Res , vol.67 , pp. 3043-3053
    • Feng, Z.1    Hu, W.2    de, S.E.3    Teresky, A.K.4    Jin, S.5    Lowe, S.6
  • 87
    • 74849113290 scopus 로고    scopus 로고
    • The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions
    • Matthew E.M., Hart L.S., Astrinidis A., Navaraj A., Dolloff N.G., Dicker D.T., et al. The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions. Cell Cycle 2009, 8:4168-4175.
    • (2009) Cell Cycle , vol.8 , pp. 4168-4175
    • Matthew, E.M.1    Hart, L.S.2    Astrinidis, A.3    Navaraj, A.4    Dolloff, N.G.5    Dicker, D.T.6
  • 88
    • 84897356294 scopus 로고    scopus 로고
    • Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway
    • Havel J.J., Li Z., Cheng D., Peng J., Fu H. Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway. Oncogene 2014, 10.1038/onc. 2014.91.
    • (2014) Oncogene
    • Havel, J.J.1    Li, Z.2    Cheng, D.3    Peng, J.4    Fu, H.5
  • 89
    • 34247391127 scopus 로고    scopus 로고
    • Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins
    • Lam Y.W., Lamond A.I., Mann M., Andersen J.S. Analysis of nucleolar protein dynamics reveals the nuclear degradation of ribosomal proteins. Curr Biol 2007, 17:749-760.
    • (2007) Curr Biol , vol.17 , pp. 749-760
    • Lam, Y.W.1    Lamond, A.I.2    Mann, M.3    Andersen, J.S.4
  • 90
    • 84874995247 scopus 로고    scopus 로고
    • Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1
    • Ben-Sahra I., Howell J.J., Asara J.M., Manning B.D. Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science 2013, 339:1323-1328.
    • (2013) Science , vol.339 , pp. 1323-1328
    • Ben-Sahra, I.1    Howell, J.J.2    Asara, J.M.3    Manning, B.D.4
  • 91
    • 84874961313 scopus 로고    scopus 로고
    • Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis
    • Robitaille A.M., Christen S., Shimobayashi M., Cornu M., Fava L.L., Moes S., et al. Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis. Science 2013, 339:1320-1323.
    • (2013) Science , vol.339 , pp. 1320-1323
    • Robitaille, A.M.1    Christen, S.2    Shimobayashi, M.3    Cornu, M.4    Fava, L.L.5    Moes, S.6
  • 92
    • 70450204007 scopus 로고    scopus 로고
    • An emerging role of mTOR in lipid biosynthesis
    • Laplante M., Sabatini D.M. An emerging role of mTOR in lipid biosynthesis. Curr Biol 2009, 19:R1046-R1052.
    • (2009) Curr Biol , vol.19 , pp. R1046-R1052
    • Laplante, M.1    Sabatini, D.M.2
  • 93
    • 84863736613 scopus 로고    scopus 로고
    • Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53
    • Bywater M.J., Poortinga G., Sanij E., Hein N., Peck A., Cullinane C., et al. Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53. Cancer Cell 2012, 22:51-65.
    • (2012) Cancer Cell , vol.22 , pp. 51-65
    • Bywater, M.J.1    Poortinga, G.2    Sanij, E.3    Hein, N.4    Peck, A.5    Cullinane, C.6
  • 94
    • 77949495196 scopus 로고    scopus 로고
    • The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer
    • Drygin D., Rice W.G., Grummt I. The RNA polymerase I transcription machinery: an emerging target for the treatment of cancer. Annu Rev Pharmacol Toxicol 2010, 50:131-156.
    • (2010) Annu Rev Pharmacol Toxicol , vol.50 , pp. 131-156
    • Drygin, D.1    Rice, W.G.2    Grummt, I.3


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