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Volumn 299, Issue 6, 2010, Pages

Arginine-induced stimulation of protein synthesis and survival in IPEC-J2 cells is mediated by mTOR but not nitric oxide

Author keywords

Cell growth; Eukaryotic initiation factor 4E binding protein 1; p70 ribosomal protein S6 kinase; Rapamycin; S nitroso N acetylpenicillamine

Indexed keywords

AMINOGUANIDINE; ARGININE; CITRULLINE; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; N ACETYL S NITROSOPENICILLAMINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROLINE; RAPAMYCIN; S6 KINASE;

EID: 78649639782     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00068.2010     Document Type: Article
Times cited : (71)

References (46)
  • 1
    • 33750155593 scopus 로고    scopus 로고
    • Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase
    • DOI 10.1038/sj.onc.1209882, PII 1209882
    • Avruch J, Hara K, Lin Y, Liu M, Long X, Ortiz-Vega S, Yonezawa K. Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Oncogene 25: 6361-6372, 2006. (Pubitemid 44596154)
    • (2006) Oncogene , vol.25 , Issue.48 , pp. 6361-6372
    • Avruch, J.1    Hara, K.2    Lin, Y.3    Liu, M.4    Long, X.5    Ortiz-Vega, S.6    Yonezawa, K.7
  • 3
    • 0027291842 scopus 로고
    • Intestinal arginine metabolism during development. Evidence for de novo synthesis of L-arginine in newborn pig enterocytes
    • Blachier F, M'Rabet-Touil H, Posho L, Darcy-Vrillon B, Duee PH. Intestinal arginine metabolism during development. Evidence for de novo synthesis of L-arginine in newborn pig enterocytes. Eur J Biochem 216: 109-117, 1993.
    • (1993) Eur J Biochem , vol.216 , pp. 109-117
    • Blachier, F.1    M'Rabet-Touil, H.2    Posho, L.3    Darcy-Vrillon, B.4    Duee, P.H.5
  • 5
    • 0029055145 scopus 로고
    • Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue
    • Chen J, Zheng XF, Brown EJ, Schreiber SL. Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc Natl Acad Sci USA 92: 4947-4951, 1995.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4947-4951
    • Chen, J.1    Zheng, X.F.2    Brown, E.J.3    Schreiber, S.L.4
  • 7
    • 33750058023 scopus 로고    scopus 로고
    • Upstream of the mammalian target of rapamycin: Do all roads pass through mTOR?
    • Corradetti MN, Guan KL. Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? Oncogene 25: 6347-6360, 2006.
    • (2006) Oncogene , vol.25 , pp. 6347-6360
    • Corradetti, M.N.1    Guan, K.L.2
  • 9
    • 0035256928 scopus 로고    scopus 로고
    • Enterocyte digestive enzyme activity along the crypt-villus and longitudinal axes in the neonatal pig small intestine
    • Fan MZ, Stoll B, Jiang R, Burrin DG. Enterocyte digestive enzyme activity along the crypt-villus and longitudinal axes in the neonatal pig small intestine. J Anim Sci 79: 371-381, 2001.
    • (2001) J Anim Sci , vol.79 , pp. 371-381
    • Fan, M.Z.1    Stoll, B.2    Jiang, R.3    Burrin, D.G.4
  • 11
    • 0037097863 scopus 로고    scopus 로고
    • Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
    • Fingar DC, Salama S, Tsou C, Harlow E, Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev 16: 1472-1487, 2002.
    • (2002) Genes Dev , vol.16 , pp. 1472-1487
    • Fingar, D.C.1    Salama, S.2    Tsou, C.3    Harlow, E.4    Blenis, J.5
  • 12
    • 44449165370 scopus 로고    scopus 로고
    • Intracellular mechanisms of metabolism regulation: The role of signaling via the mammalian target of rapamycin pathway and other routes
    • Flati V, Pasini E, D'Antona G, Speca S, Toniato E, Martinotti S. Intracellular mechanisms of metabolism regulation: the role of signaling via the mammalian target of rapamycin pathway and other routes. Am J Cardiol 101: 16E-21E, 2008.
    • (2008) Am J Cardiol , vol.101
    • Flati, V.1    Pasini, E.2    D'Antona, G.3    Speca, S.4    Toniato, E.5    Martinotti, S.6
  • 13
    • 0029902824 scopus 로고    scopus 로고
    • An important role for endogenous synthesis of arginine in maintaining arginine homeostasis in neonatal pigs
    • Flynn NE, Wu G. An important role for endogenous synthesis of arginine in maintaining arginine homeostasis in neonatal pigs. Am J Physiol Regul Integr Comp Physiol 271: R1149-R1155, 1996.
    • (1996) Am J Physiol Regul Integr Comp Physiol , vol.271
    • Flynn, N.E.1    Wu, G.2
  • 14
  • 15
    • 59749101669 scopus 로고    scopus 로고
    • mTOR: Dissecting regulation and mechanism of action to understand human disease
    • Goberdhan DC, Boyd CA. mTOR: dissecting regulation and mechanism of action to understand human disease. Biochem Soc Trans 37: 213-216, 2009.
    • (2009) Biochem Soc Trans , vol.37 , pp. 213-216
    • Goberdhan, D.C.1    Boyd, C.A.2
  • 16
    • 0032486268 scopus 로고    scopus 로고
    • Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
    • Hara K, Yonezawa K, Weng QP, Kozlowski MT, Belham C, Avruch J. Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem 273: 14484-14494, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 14484-14494
    • Hara, K.1    Yonezawa, K.2    Weng, Q.P.3    Kozlowski, M.T.4    Belham, C.5    Avruch, J.6
  • 17
    • 23944431858 scopus 로고    scopus 로고
    • Nutritional control of gene expression: How mammalian cells respond to amino acid limitation
    • Kilberg MS, Pan YX, Chen H, Leung-Pineda V. Nutritional control of gene expression: how mammalian cells respond to amino acid limitation. Annu Rev Nutr 25: 59-85, 2005.
    • (2005) Annu Rev Nutr , vol.25 , pp. 59-85
    • Kilberg, M.S.1    Pan, Y.X.2    Chen, H.3    Leung-Pineda, V.4
  • 19
    • 1542286855 scopus 로고    scopus 로고
    • Dietary arginine supplementation enhances the growth of milk-fed young pigs
    • Kim SW, Wu G. Dietary arginine supplementation enhances the growth of milk-fed young pigs. J Nutr 134: 625-630, 2004.
    • (2004) J Nutr , vol.134 , pp. 625-630
    • Kim, S.W.1    Wu, G.2
  • 20
    • 58249100087 scopus 로고    scopus 로고
    • The human neonatal small intestine has the potential for arginine synthesis: Developmental changes in the expression of arginine-synthesizing and -catabolizing enzymes
    • Kohler ES, Sankaranarayanan S, Van Ginneken CJ, van Dijk P, Vermeulen JL, Ruijter JM, Lamers WH, Bruder E. The human neonatal small intestine has the potential for arginine synthesis: developmental changes in the expression of arginine-synthesizing and -catabolizing enzymes. BMC Dev Biol 8: 107, 2008.
    • (2008) BMC Dev Biol , vol.8 , pp. 107
    • Kohler, E.S.1    Sankaranarayanan, S.2    Van Ginneken, C.J.3    Van Dijk, P.4    Vermeulen, J.L.5    Ruijter, J.M.6    Lamers, W.H.7    Bruder, E.8
  • 21
    • 54249097805 scopus 로고    scopus 로고
    • Role of nitric oxide in the gastrointestinal tract
    • Lanas A. Role of nitric oxide in the gastrointestinal tract. Arthritis Res Ther 10 Suppl 2: S4, 2008.
    • (2008) Arthritis Res Ther , vol.10 , Issue.SUPPL. 2
    • Lanas, A.1
  • 22
    • 33847663804 scopus 로고    scopus 로고
    • Arginine deficiency in preconfluent intestinal Caco-2 cells modulates expression of proteins involved in proliferation, apoptosis, and heat shock response
    • Lenaerts K, Renes J, Bouwman FG, Noben JP, Robben J, Smit E, Mariman EC. Arginine deficiency in preconfluent intestinal Caco-2 cells modulates expression of proteins involved in proliferation, apoptosis, and heat shock response. Proteomics 7: 565-577, 2007.
    • (2007) Proteomics , vol.7 , pp. 565-577
    • Lenaerts, K.1    Renes, J.2    Bouwman, F.G.3    Noben, J.P.4    Robben, J.5    Smit, E.6    Mariman, E.C.7
  • 26
    • 51049087053 scopus 로고    scopus 로고
    • Arginine stimulates cdx2-transformed intestinal epithelial cell migration via a mechanism requiring both nitric oxide and phosphorylation of p70 S6 kinase
    • Rhoads JM, Liu Y, Niu X, Surendran S, Wu G. Arginine stimulates cdx2-transformed intestinal epithelial cell migration via a mechanism requiring both nitric oxide and phosphorylation of p70 S6 kinase. J Nutr 138: 1652-1657, 2008.
    • (2008) J Nutr , vol.138 , pp. 1652-1657
    • Rhoads, J.M.1    Liu, Y.2    Niu, X.3    Surendran, S.4    Wu, G.5
  • 29
    • 0032538098 scopus 로고    scopus 로고
    • De novo synthesis of arginine and ornithine from citrulline in human colon carcinoma cells: Metabolic fate of L-ornithine
    • Selamnia M, Robert V, Mayeur C, Delpal S, Blachier F. De novo synthesis of arginine and ornithine from citrulline in human colon carcinoma cells: metabolic fate of L-ornithine. Biochim Biophys Acta 1425: 93-102, 1998.
    • (1998) Biochim Biophys Acta , vol.1425 , pp. 93-102
    • Selamnia, M.1    Robert, V.2    Mayeur, C.3    Delpal, S.4    Blachier, F.5
  • 30
    • 77952617778 scopus 로고    scopus 로고
    • Growing rats respond to a sulfur amino acid-deficient diet by phosphorylation of the α-subunit of eukaryotic initiation factor 2 heterotrimeric complex and induction of adaptive components of the integrated stress response
    • Sikalidis AK, Stipanuk MH. Growing rats respond to a sulfur amino acid-deficient diet by phosphorylation of the α-subunit of eukaryotic initiation factor 2 heterotrimeric complex and induction of adaptive components of the integrated stress response. J Nutr 140: 1080-1085, 2010.
    • (2010) J Nutr , vol.140 , pp. 1080-1085
    • Sikalidis, A.K.1    Stipanuk, M.H.2
  • 31
    • 33746841282 scopus 로고    scopus 로고
    • Enteral nutrient intake level determines intestinal protein synthesis and accretion rates in neonatal pigs
    • Stoll B, Chang X, Fan MZ, Reeds PJ, Burrin DG. Enteral nutrient intake level determines intestinal protein synthesis and accretion rates in neonatal pigs. Am J Physiol Gastrointest Liver Physiol 279: G288-G294, 2000.
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.279
    • Stoll, B.1    Chang, X.2    Fan, M.Z.3    Reeds, P.J.4    Burrin, D.G.5
  • 32
    • 77951666440 scopus 로고    scopus 로고
    • L-Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells
    • Tan B, Yin Y, Kong X, Li P, Li X, Gao H, Li X, Huang R, Wu G. L-Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells. Amino Acids 38: 1227-1235, 2010.
    • (2010) Amino Acids , vol.38 , pp. 1227-1235
    • Tan, B.1    Yin, Y.2    Kong, X.3    Li, P.4    Li, X.5    Gao, H.6    Li, X.7    Huang, R.8    Wu, G.9
  • 34
    • 33745670399 scopus 로고    scopus 로고
    • Citrulline is an effective arginine precursor in enterally fed neonatal piglets
    • Urschel KL, Shoveller AK, Uwiera RR, Pencharz PB, Ball RO. Citrulline is an effective arginine precursor in enterally fed neonatal piglets. J Nutr 136: 1806-1813, 2006.
    • (2006) J Nutr , vol.136 , pp. 1806-1813
    • Urschel, K.L.1    Shoveller, A.K.2    Uwiera, R.R.3    Pencharz, P.B.4    Ball, R.O.5
  • 35
    • 0037305059 scopus 로고    scopus 로고
    • Arginine deprivation and tumour cell death: Arginase and its inhibition
    • DOI 10.1023/A:1022451705701
    • Wheatley DN, Philip R, Campbell E. Arginine deprivation and tumour cell death: arginase and its inhibition. Mol Cell Biochem 244: 177-185, 2003. (Pubitemid 36411071)
    • (2003) Molecular and Cellular Biochemistry , vol.244 , Issue.1-2 , pp. 177-185
    • Wheatley, D.N.1    Philip, R.2    Campbell, E.3
  • 37
    • 0030812153 scopus 로고    scopus 로고
    • Synthesis of citrulline and arginine from proline in enterocytes of postnatal pigs
    • Wu G. Synthesis of citrulline and arginine from proline in enterocytes of postnatal pigs. Am J Physiol Gastrointest Liver Physiol 272: G1382-G1390, 1997.
    • (1997) Am J Physiol Gastrointest Liver Physiol , vol.272
    • Wu, G.1
  • 38
    • 14444272504 scopus 로고    scopus 로고
    • Intestinal mucosal amino acid catabolism
    • Wu G. Intestinal mucosal amino acid catabolism. J Nutr 128: 1249-1252, 1998.
    • (1998) J Nutr , vol.128 , pp. 1249-1252
    • Wu, G.1
  • 40
    • 0031447041 scopus 로고    scopus 로고
    • Endogenous synthesis of arginine plays an important role in maintaining arginine homeostasis in postweaning growing pigs
    • Wu G, Davis PK, Flynn NE, Knabe DA, Davidson JT. Endogenous synthesis of arginine plays an important role in maintaining arginine homeostasis in postweaning growing pigs. J Nutr 127: 2342-2349, 1997. (Pubitemid 28018910)
    • (1997) Journal of Nutrition , vol.127 , Issue.12 , pp. 2342-2349
    • Wu, G.1    Davis, P.K.2    Flynn, N.E.3    Knabe, D.A.4    Davidson, J.T.5
  • 43
    • 0032533159 scopus 로고    scopus 로고
    • Arginine metabolism: Nitric oxide and beyond
    • Wu G, Morris SM Jr. Arginine metabolism: nitric oxide and beyond. Biochem J 336: 1-17, 1998.
    • (1998) Biochem J , vol.336 , pp. 1-17
    • Wu, G.1    Morris Jr., S.M.2
  • 44
    • 42449130835 scopus 로고    scopus 로고
    • Dietary arginine supplementation increases mTOR signaling activity in skeletal muscle of neonatal pigs
    • Yao K, Yin YL, Chu W, Liu Z, Deng D, Li T, Huang R, Zhang J, Tan B, Wang W, Wu G. Dietary arginine supplementation increases mTOR signaling activity in skeletal muscle of neonatal pigs. J Nutr 138: 867-872, 2008.
    • (2008) J Nutr , vol.138 , pp. 867-872
    • Yao, K.1    Yin, Y.L.2    Chu, W.3    Liu, Z.4    Deng, D.5    Li, T.6    Huang, R.7    Zhang, J.8    Tan, B.9    Wang, W.10    Wu, G.11
  • 45
    • 0026088451 scopus 로고
    • Depletion of dietary arginine inhibits growth of metastatic tumor
    • Yeatman TJ, Risley GL, Brunson ME. Depletion of dietary arginine inhibits growth of metastatic tumor. Arch Surg 126: 1376-1381, 1991.
    • (1991) Arch Surg , vol.126 , pp. 1376-1381
    • Yeatman, T.J.1    Risley, G.L.2    Brunson, M.E.3
  • 46
    • 46249126792 scopus 로고    scopus 로고
    • Dietary arginine supplementation affects microvascular development in the small intestine of early-weaned pigs
    • Zhan Z, Ou D, Piao X, Kim SW, Liu Y, Wang J. Dietary arginine supplementation affects microvascular development in the small intestine of early-weaned pigs. J Nutr 138: 1304-1309, 2008.
    • (2008) J Nutr , vol.138 , pp. 1304-1309
    • Zhan, Z.1    Ou, D.2    Piao, X.3    Kim, S.W.4    Liu, Y.5    Wang, J.6


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