-
1
-
-
84872967522
-
Cancer statistics, 2013. CA Cancer J Clin
-
[PMID: 23335087]
-
Siegel R, Naishadham D and Jemal A. Cancer statistics, 2013. CA Cancer J Clin. Jan 2013; 63 (1): 11-30. [PMID: 23335087]
-
(2013)
Jan
, vol.63
, Issue.1
, pp. 11-30
-
-
Siegel, R.1
Naishadham, D.2
Jemal, A.3
-
3
-
-
39749183343
-
Analysis of mortality rates for pancreatic cancer across the world
-
[PMID: 18695761]
-
Hariharan D, Saied A and Kocher HM. Analysis of mortality rates for pancreatic cancer across the world. HPB (Oxford). 2008; 10 (1): 58-62. [PMID: 18695761]
-
(2008)
HPB (Oxford)
, vol.10
, Issue.1
, pp. 58-62
-
-
Hariharan, D.1
Saied, A.2
Kocher, H.M.3
-
4
-
-
77955635233
-
Cancer statistics, 2010. CA Cancer J Clin
-
[PMID: 20610543]
-
Jemal A, Siegel R, Xu J and Ward E. Cancer statistics, 2010. CA Cancer J Clin. Sep-Oct 2010; 60 (5): 277-300. [PMID: 20610543]
-
(2010)
Sep-Oct
, vol.60
, Issue.5
, pp. 277-300
-
-
Jemal, A.1
Siegel, R.2
Xu, J.3
Ward, E.4
-
5
-
-
18844431062
-
Pancreatic cancer: Basic and clinical aspects. Gastroenterology
-
[PMID: 15887154]
-
Schneider G, Siveke JT, Eckel F and Schmid RM. Pancreatic cancer: basic and clinical aspects. Gastroenterology. May 2005; 128 (6): 1606-1625. [PMID: 15887154]
-
(2005)
May
, vol.128
, Issue.6
, pp. 1606-1625
-
-
Schneider, G.1
Siveke, J.T.2
Eckel, F.3
Schmid, R.M.4
-
6
-
-
0035020633
-
Pancreatic intraepithelial neoplasia: A new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol
-
[PMID: 11342768]
-
Hruban RH, Adsay NV, Albores-Saavedra J, Compton C, Garrett ES, Goodman SN, et al. Pancreatic intraepithelial neoplasia: a new nomenclature and classification system for pancreatic duct lesions. Am J Surg Pathol. May 2001; 25 (5): 579-586. [PMID: 11342768]
-
(2001)
May
, vol.25
, Issue.5
, pp. 579-586
-
-
Hruban, R.H.1
Adsay, N.V.2
Albores-Saavedra, J.3
Compton, C.4
Garrett, E.S.5
Goodman, S.N.6
-
7
-
-
34248335374
-
Pancreatic adenocarcinoma: Update on the surgical pathology of carcinomas of ductal origin and PanINs
-
Feb, [PMID: 17486053]
-
Hruban RH and Fukushima N. Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs. Mod Pathol. Feb 2007; 20 Suppl 1: S61-70. [PMID: 17486053]
-
(2007)
Mod Pathol
, vol.20
, pp. S61-S70
-
-
Hruban, R.H.1
Fukushima, N.2
-
8
-
-
0033523268
-
Cancer risks in BRCA2 mutation carriers. J Natl Cancer Inst
-
[PMID: 10433620]
-
Breast Cancer Linkage C. Cancer risks in BRCA2 mutation carriers. J Natl Cancer Inst. Aug 4 1999; 91 (15): 1310-1316. [PMID: 10433620]
-
(1999)
Aug 4
, vol.91
, Issue.15
, pp. 1310-1316
-
-
Breast Cancer Linkage, C.1
-
9
-
-
0029129816
-
Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations. N Engl J Med
-
[PMID: 7666916]
-
Goldstein AM, Fraser MC, Struewing JP, Hussussian CJ, Ranade K, Zametkin DP, et al. Increased risk of pancreatic cancer in melanoma-prone kindreds with p16INK4 mutations. N Engl J Med. Oct 12 1995; 333 (15): 970-974. [PMID: 7666916]
-
(1995)
Oct 12
, vol.333
, Issue.15
, pp. 970-974
-
-
Goldstein, A.M.1
Fraser, M.C.2
Struewing, J.P.3
Hussussian, C.J.4
Ranade, K.5
Zametkin, D.P.6
-
10
-
-
77957150824
-
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer
-
[PMID: 20814421]
-
Morris JPt, Wang SC and Hebrok M. KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer. Oct 2010; 10 (10): 683-695. [PMID: 20814421]
-
(2010)
Oct
, vol.10
, Issue.10
, pp. 683-695
-
-
Morris, J.P.1
Wang, S.C.2
Hebrok, M.3
-
11
-
-
0028268635
-
K-ras and p53 gene mutations in pancreatic cancer: Ductal and nonductal tumors progress through different genetic lesions. Cancer Res
-
[PMID: 8137263]
-
Pellegata NS, Sessa F, Renault B, Bonato M, Leone BE, Solcia E, et al. K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions. Cancer Res. Mar 15 1994; 54 (6): 1556-1560. [PMID: 8137263]
-
(1994)
Mar 15
, vol.54
, Issue.6
, pp. 1556-1560
-
-
Pellegata, N.S.1
Sessa, F.2
Renault, B.3
Bonato, M.4
Leone, B.E.5
Solcia, E.6
-
12
-
-
0018240421
-
A gene complex controlling segmentation in Drosophila. Nature
-
[PMID: 103000]
-
Lewis EB. A gene complex controlling segmentation in Drosophila. Nature. Dec 7 1978; 276 (5688): 565-570. [PMID: 103000]
-
(1978)
Dec 7
, vol.276
, Issue.5688
, pp. 565-570
-
-
Lewis, E.B.1
-
13
-
-
0019133661
-
Mutations affecting segment number and polarity in Drosophila. Nature
-
[PMID: 6776413]
-
Nusslein-Volhard C and Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature. Oct 30 1980; 287 (5785): 795-801. [PMID: 6776413]
-
(1980)
Oct 30
, vol.287
, Issue.5785
, pp. 795-801
-
-
Nusslein-Volhard, C.1
Wieschaus, E.2
-
14
-
-
0028909706
-
Hedgehog and beyond. Cell
-
[PMID: 7867057]
-
Perrimon N. Hedgehog and beyond. Cell. Feb 24 1995; 80 (4): 517-520. [PMID: 7867057]
-
(1995)
Feb 24
, vol.80
, Issue.4
, pp. 517-520
-
-
Perrimon, N.1
-
15
-
-
0029750190
-
Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science
-
[PMID: 8662546]
-
Vortkamp A, Lee K, Lanske B, Segre GV, Kronenberg HM and Tabin CJ. Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science. Aug 2 1996; 273 (5275): 613-622. [PMID: 8662546]
-
(1996)
Aug 2
, vol.273
, Issue.5275
, pp. 613-622
-
-
Vortkamp, A.1
Lee, K.2
Lanske, B.3
Segre, G.V.4
Kronenberg, H.M.5
Tabin, C.J.6
-
16
-
-
0028837742
-
Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol
-
[PMID: 7589793]
-
Bitgood MJ and McMahon AP. Hedgehog and Bmp genes are coexpressed at many diverse sites of cell-cell interaction in the mouse embryo. Dev Biol. Nov 1995; 172 (1): 126-138. [PMID: 7589793]
-
(1995)
Nov
, vol.172
, Issue.1
, pp. 126-138
-
-
Bitgood, M.J.1
McMahon, A.P.2
-
17
-
-
0033179931
-
Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. Neuron
-
[PMID: 10482238]
-
Parmantier E, Lynn B, Lawson D, Turmaine M, Namini SS, Chakrabarti L, et al. Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. Neuron. Aug 1999; 23 (4): 713-724. [PMID: 10482238]
-
(1999)
Aug
, vol.23
, Issue.4
, pp. 713-724
-
-
Parmantier, E.1
Lynn, B.2
Lawson, D.3
Turmaine, M.4
Namini, S.S.5
Chakrabarti, L.6
-
18
-
-
0028127842
-
Hedgehog, the floor plate, and the zone of polarizing activity. Cell
-
[PMID: 8293455]
-
Smith JC. Hedgehog, the floor plate, and the zone of polarizing activity. Cell. Jan 28 1994; 76 (2): 193-196. [PMID: 8293455]
-
(1994)
Jan 28
, vol.76
, Issue.2
, pp. 193-196
-
-
Smith, J.C.1
-
19
-
-
0034928252
-
Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon. Development
-
[PMID: 11493571]
-
Tekki-Kessaris N, Woodruff R, Hall AC, Gaffield W, Kimura S, Stiles CD, et al. Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon. Development. Jul 2001; 128 (13): 2545-2554. [PMID: 11493571]
-
(2001)
Jul
, vol.128
, Issue.13
, pp. 2545-2554
-
-
Tekki-Kessaris, N.1
Woodruff, R.2
Hall, A.C.3
Gaffield, W.4
Kimura, S.5
Stiles, C.D.6
-
20
-
-
0031922720
-
FGF-, BMP-and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. Development
-
[PMID: 9477322]
-
Kim HJ, Rice DP, Kettunen PJ and Thesleff I. FGF-, BMP-and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development. Development. Apr 1998; 125 (7): 1241-1251. [PMID: 9477322]
-
(1998)
Apr
, vol.125
, Issue.7
, pp. 1241-1251
-
-
Kim, H.J.1
Rice, D.P.2
Kettunen, P.J.3
Thesleff, I.4
-
21
-
-
0029347087
-
Patterning activities of vertebrate hedgehog proteins in the developing eye and brain. Curr Biol
-
[PMID: 7583153]
-
Ekker SC, Ungar AR, Greenstein P, von Kessler DP, Porter JA, Moon RT, et al. Patterning activities of vertebrate hedgehog proteins in the developing eye and brain. Curr Biol. Aug 1 1995; 5 (8): 944-955. [PMID: 7583153]
-
(1995)
Aug 1
, vol.5
, Issue.8
, pp. 944-955
-
-
Ekker, S.C.1
Ungar, A.R.2
Greenstein, P.3
von Kessler, D.P.4
Porter, J.A.5
Moon, R.T.6
-
22
-
-
0033916281
-
Hedgehog signals regulate multiple aspects of gastrointestinal development. Development
-
[PMID: 10821773]
-
Ramalho-Santos M, Melton DA and McMahon AP. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development. Jun 2000; 127 (12): 2763-2772. [PMID: 10821773]
-
(2000)
Jun
, vol.127
, Issue.12
, pp. 2763-2772
-
-
Ramalho-Santos, M.1
Melton, D.A.2
McMahon, A.P.3
-
23
-
-
0031683165
-
Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet
-
[PMID: 9731531]
-
Motoyama J, Liu J, Mo R, Ding Q, Post M and Hui CC. Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet. Sep 1998; 20 (1): 54-57. [PMID: 9731531]
-
(1998)
Sep
, vol.20
, Issue.1
, pp. 54-57
-
-
Motoyama, J.1
Liu, J.2
Mo, R.3
Ding, Q.4
Post, M.5
Hui, C.C.6
-
24
-
-
14844331446
-
Hedgehog signaling regulates expansion of pancreatic epithelial cells. Dev Biol
-
[PMID: 15766752]
-
Kawahira H, Scheel DW, Smith SB, German MS and Hebrok M. Hedgehog signaling regulates expansion of pancreatic epithelial cells. Dev Biol. Apr 1 2005; 280 (1): 111-121. [PMID: 15766752]
-
(2005)
Apr 1
, vol.280
, Issue.1
, pp. 111-121
-
-
Kawahira, H.1
Scheel, D.W.2
Smith, S.B.3
German, M.S.4
Hebrok, M.5
-
25
-
-
0031661708
-
Epithelial-mesenchymal signaling during the regionalization of the chick gut. Development
-
[PMID: 9655802]
-
Roberts DJ, Smith DM, Goff DJ and Tabin CJ. Epithelial-mesenchymal signaling during the regionalization of the chick gut. Development. Aug 1998; 125 (15): 2791-2801. [PMID: 9655802]
-
(1998)
Aug
, vol.125
, Issue.15
, pp. 2791-2801
-
-
Roberts, D.J.1
Smith, D.M.2
Goff, D.J.3
Tabin, C.J.4
-
26
-
-
0029843937
-
Regulation of patched by sonic hedgehog in the developing neural tube. Proc Natl Acad Sci U S A
-
[PMID: 8790332]
-
Marigo V and Tabin CJ. Regulation of patched by sonic hedgehog in the developing neural tube. Proc Natl Acad Sci U S A. Sep 3 1996; 93 (18): 9346-9351. [PMID: 8790332]
-
(1996)
Sep 3
, vol.93
, Issue.18
, pp. 9346-9351
-
-
Marigo, V.1
Tabin, C.J.2
-
27
-
-
33646058889
-
Hedgehog signaling in the normal and diseased pancreas. Pancreas
-
[PMID: 16552330]
-
Kayed H, Kleeff J, Osman T, Keleg S, Buchler MW and Friess H. Hedgehog signaling in the normal and diseased pancreas. Pancreas. Mar 2006; 32 (2): 119-129. [PMID: 16552330]
-
(2006)
Mar
, vol.32
, Issue.2
, pp. 119-129
-
-
Kayed, H.1
Kleeff, J.2
Osman, T.3
Keleg, S.4
Buchler, M.W.5
Friess, H.6
-
28
-
-
0031571621
-
Evidence for the involvement of the Gli gene family in embryonic mouse lung development. Dev Biol
-
[PMID: 9268579]
-
Grindley JC, Bellusci S, Perkins D and Hogan BL. Evidence for the involvement of the Gli gene family in embryonic mouse lung development. Dev Biol. Aug 15 1997; 188 (2): 337-348. [PMID: 9268579]
-
(1997)
Aug 15
, vol.188
, Issue.2
, pp. 337-348
-
-
Grindley, J.C.1
Bellusci, S.2
Perkins, D.3
Hogan, B.L.4
-
29
-
-
80054795610
-
Ectopic overexpression of Sonic Hedgehog (Shh) induces stromal expansion and metaplasia in the adult murine pancreas. Neoplasia
-
[PMID: 22028618]
-
Fendrich V, Oh E, Bang S, Karikari C, Ottenhof N, Bisht S, et al. Ectopic overexpression of Sonic Hedgehog (Shh) induces stromal expansion and metaplasia in the adult murine pancreas. Neoplasia. Oct 2011; 13 (10): 923-930. [PMID: 22028618]
-
(2011)
Oct
, vol.13
, Issue.10
, pp. 923-930
-
-
Fendrich, V.1
Oh, E.2
Bang, S.3
Karikari, C.4
Ottenhof, N.5
Bisht, S.6
-
30
-
-
70349974840
-
Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer. Oncogene
-
[PMID: 19633682]
-
Bailey JM, Mohr AM and Hollingsworth MA. Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer. Oncogene. Oct 8 2009; 28 (40): 3513-3525. [PMID: 19633682]
-
(2009)
Oct 8
, vol.28
, Issue.40
, pp. 3513-3525
-
-
Bailey, J.M.1
Mohr, A.M.2
Hollingsworth, M.A.3
-
31
-
-
63149124772
-
Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci U S A
-
[PMID: 19246386]
-
Tian H, Callahan CA, DuPree KJ, Darbonne WC, Ahn CP, Scales SJ, et al. Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis. Proc Natl Acad Sci U S A. Mar 17 2009; 106 (11): 4254-4259. [PMID: 19246386]
-
(2009)
Mar 17
, vol.106
, Issue.11
, pp. 4254-4259
-
-
Tian, H.1
Callahan, C.A.2
DuPree, K.J.3
Darbonne, W.C.4
Ahn, C.P.5
Scales, S.J.6
-
32
-
-
52149119128
-
A paracrine requirement for hedgehog signalling in cancer. Nature
-
[PMID: 18754008]
-
Yauch RL, Gould SE, Scales SJ, Tang T, Tian H, Ahn CP, et al. A paracrine requirement for hedgehog signalling in cancer. Nature. Sep 18 2008; 455 (7211): 406-410. [PMID: 18754008]
-
(2008)
Sep 18
, vol.455
, Issue.7211
, pp. 406-410
-
-
Yauch, R.L.1
Gould, S.E.2
Scales, S.J.3
Tang, T.4
Tian, H.5
Ahn, C.P.6
-
33
-
-
84904994417
-
Stromal response to Hedgehog signaling restrains pancreatic cancer progression. Proc Natl Acad Sci U S A
-
[PMID: 25024225]
-
Lee JJ, Perera RM, Wang H, Wu DC, Liu XS, Han S, et al. Stromal response to Hedgehog signaling restrains pancreatic cancer progression. Proc Natl Acad Sci U S A. Jul 29 2014; 111 (30): E3091-3100. [PMID: 25024225]
-
(2014)
Jul 29
, vol.111
, Issue.30
, pp. E3091-E3100
-
-
Lee, J.J.1
Perera, R.M.2
Wang, H.3
Wu, D.C.4
Liu, X.S.5
Han, S.6
-
34
-
-
80155146828
-
Mechanisms of Hedgehog signalling in cancer. Growth Factors
-
[PMID: 21875383]
-
Marini KD, Payne BJ, Watkins DN and Martelotto LG. Mechanisms of Hedgehog signalling in cancer. Growth Factors. Dec 2011; 29 (6): 221-234. [PMID: 21875383]
-
(2011)
Dec
, vol.29
, Issue.6
, pp. 221-234
-
-
Marini, K.D.1
Payne, B.J.2
Watkins, D.N.3
Martelotto, L.G.4
-
35
-
-
84866490065
-
Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer. Mol Cancer Res
-
[PMID: 22859707]
-
Hwang RF, Moore TT, Hattersley MM, Scarpitti M, Yang B, Devereaux E, et al. Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer. Mol Cancer Res. Sep 2012; 10 (9): 1147-1157. [PMID: 22859707]
-
(2012)
Sep
, vol.10
, Issue.9
, pp. 1147-1157
-
-
Hwang, R.F.1
Moore, T.T.2
Hattersley, M.M.3
Scarpitti, M.4
Yang, B.5
Devereaux, E.6
-
36
-
-
84883023860
-
Signaling pathway and molecular subgroups of medulloblastoma
-
[PMID: 23826403]
-
Li KK, Lau KM and Ng HK. Signaling pathway and molecular subgroups of medulloblastoma. Int J Clin Exp Pathol. 2013; 6 (7): 1211-1222. [PMID: 23826403]
-
(2013)
Int J Clin Exp Pathol
, vol.6
, Issue.7
, pp. 1211-1222
-
-
Li, K.K.1
Lau, K.M.2
Ng, H.K.3
-
37
-
-
33746888182
-
Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer. Cancer Res
-
[PMID: 16849549]
-
Nakashima H, Nakamura M, Yamaguchi H, Yamanaka N, Akiyoshi T, Koga K, et al. Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer. Cancer Res. Jul 15 2006; 66 (14): 7041-7049. [PMID: 16849549]
-
(2006)
Jul 15
, vol.66
, Issue.14
, pp. 7041-7049
-
-
Nakashima, H.1
Nakamura, M.2
Yamaguchi, H.3
Yamanaka, N.4
Akiyoshi, T.5
Koga, K.6
-
38
-
-
84860169406
-
The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis. Proc Natl Acad Sci U S A
-
[PMID: 22493246]
-
Rajurkar M, De Jesus-Monge WE, Driscoll DR, Appleman VA, Huang H, Cotton JL, et al. The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis. Proc Natl Acad Sci U S A. Apr 24 2012; 109 (17): E1038-1047. [PMID: 22493246]
-
(2012)
Apr 24
, vol.109
, Issue.17
, pp. E1038-E1047
-
-
Rajurkar, M.1
De Jesus-Monge, W.E.2
Driscoll, D.R.3
Appleman, V.A.4
Huang, H.5
Cotton, J.L.6
-
39
-
-
5644264887
-
Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. Cancer Res
-
[PMID: 15492281]
-
Athar M, Li C, Tang X, Chi S, Zhang X, Kim AL, et al. Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. Cancer Res. Oct 15 2004; 64 (20): 7545-7552. [PMID: 15492281]
-
(2004)
Oct 15
, vol.64
, Issue.20
, pp. 7545-7552
-
-
Athar, M.1
Li, C.2
Tang, X.3
Chi, S.4
Zhang, X.5
Kim, A.L.6
-
40
-
-
33947517650
-
Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts. Int J Mol Med
-
[PMID: 17273793]
-
Lee SW, Moskowitz MA and Sims JR. Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts. Int J Mol Med. Mar 2007; 19 (3): 445-451. [PMID: 17273793]
-
(2007)
Mar
, vol.19
, Issue.3
, pp. 445-451
-
-
Lee, S.W.1
Moskowitz, M.A.2
Sims, J.R.3
-
41
-
-
33644509505
-
Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res
-
[PMID: 16489008]
-
Adolphe C, Hetherington R, Ellis T and Wainwright B. Patched1 functions as a gatekeeper by promoting cell cycle progression. Cancer Res. Feb 15 2006; 66 (4): 2081-2088. [PMID: 16489008]
-
(2006)
Feb 15
, vol.66
, Issue.4
, pp. 2081-2088
-
-
Adolphe, C.1
Hetherington, R.2
Ellis, T.3
Wainwright, B.4
-
42
-
-
34248138532
-
Sonic hedgehog-Gli1 pathway in colorectal adenocarcinomas. World J Gastroenterol
-
[PMID: 17461467]
-
Bian YH, Huang SH, Yang L, Ma XL, Xie JW and Zhang HW. Sonic hedgehog-Gli1 pathway in colorectal adenocarcinomas. World J Gastroenterol. Mar 21 2007; 13 (11): 1659-1665. [PMID: 17461467]
-
(2007)
Mar 21
, vol.13
, Issue.11
, pp. 1659-1665
-
-
Bian, Y.H.1
Huang, S.H.2
Yang, L.3
Ma, X.L.4
Xie, J.W.5
Zhang, H.W.6
-
43
-
-
84878847975
-
Sonic hedgehog signaling pathway supports cancer cell growth during cancer radiotherapy
-
[PMID: 23762282]
-
Ma J, Tian L, Cheng J, Chen Z, Xu B, Wang L, et al. Sonic hedgehog signaling pathway supports cancer cell growth during cancer radiotherapy. PLoS One. 2013; 8 (6): e65032. [PMID: 23762282]
-
(2013)
PLoS One
, vol.8
, Issue.6
-
-
Ma, J.1
Tian, L.2
Cheng, J.3
Chen, Z.4
Xu, B.5
Wang, L.6
-
44
-
-
84869382484
-
The sonic hedgehog-GLI1 signaling pathway in brain tumor development. Expert Opin Ther Targets
-
[PMID: 22992192]
-
Shahi MH, Rey JA and Castresana JS. The sonic hedgehog-GLI1 signaling pathway in brain tumor development. Expert Opin Ther Targets. Dec 2012; 16 (12): 1227-1238. [PMID: 22992192]
-
(2012)
Dec
, vol.16
, Issue.12
, pp. 1227-1238
-
-
Shahi, M.H.1
Rey, J.A.2
Castresana, J.S.3
-
45
-
-
34547110771
-
Patched1 regulates hedgehog signaling at the primary cilium. Science
-
[PMID: 17641202]
-
Rohatgi R, Milenkovic L and Scott MP. Patched1 regulates hedgehog signaling at the primary cilium. Science. Jul 20 2007; 317 (5836): 372-376. [PMID: 17641202]
-
(2007)
Jul 20
, vol.317
, Issue.5836
, pp. 372-376
-
-
Rohatgi, R.1
Milenkovic, L.2
Scott, M.P.3
-
46
-
-
33747332214
-
Repression of smoothened by patched-dependent (pro-) vitamin D3 secretion. PLoS Biol
-
[PMID: 16895439]
-
Bijlsma MF, Spek CA, Zivkovic D, van de Water S, Rezaee F and Peppelenbosch MP. Repression of smoothened by patched-dependent (pro-) vitamin D3 secretion. PLoS Biol. Jul 2006; 4 (8): e232. [PMID: 16895439]
-
(2006)
Jul
, vol.4
, Issue.8
-
-
Bijlsma, M.F.1
Spek, C.A.2
Zivkovic, D.3
van de Water, S.4
Rezaee, F.5
Peppelenbosch, M.P.6
-
47
-
-
56849116719
-
Role and regulation of human tumor suppressor SUFU in Hedgehog signaling
-
[PMID: 19055941]
-
Cheng SY and Yue S. Role and regulation of human tumor suppressor SUFU in Hedgehog signaling. Adv Cancer Res. 2008; 101: 29-43. [PMID: 19055941]
-
(2008)
Adv Cancer Res
, vol.101
, pp. 29-43
-
-
Cheng, S.Y.1
Yue, S.2
-
48
-
-
0033491071
-
Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli. J Cell Sci
-
[PMID: 10564661]
-
Stone DM, Murone M, Luoh S, Ye W, Armanini MP, Gurney A, et al. Characterization of the human suppressor of fused, a negative regulator of the zinc-finger transcription factor Gli. J Cell Sci. Dec 1999; 112 (Pt 23): 4437-4448. [PMID: 10564661]
-
(1999)
Dec
, vol.112
, pp. 4437-4448
-
-
Stone, D.M.1
Murone, M.2
Luoh, S.3
Ye, W.4
Armanini, M.P.5
Gurney, A.6
-
49
-
-
0035955642
-
Suppressor of fused negatively regulates beta-catenin signaling. J Biol Chem
-
[PMID: 11477086]
-
Meng X, Poon R, Zhang X, Cheah A, Ding Q, Hui CC, et al. Suppressor of fused negatively regulates beta-catenin signaling. J Biol Chem. Oct 26 2001; 276 (43): 40113-40119. [PMID: 11477086]
-
(2001)
Oct 26
, vol.276
, Issue.43
, pp. 40113-40119
-
-
Meng, X.1
Poon, R.2
Zhang, X.3
Cheah, A.4
Ding, Q.5
Hui, C.C.6
-
50
-
-
0033194243
-
Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1. Nat Cell Biol
-
[PMID: 10559945]
-
Kogerman P, Grimm T, Kogerman L, Krause D, Unden AB, Sandstedt B, et al. Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1. Nat Cell Biol. Sep 1999; 1 (5): 312-319. [PMID: 10559945]
-
(1999)
Sep
, vol.1
, Issue.5
, pp. 312-319
-
-
Kogerman, P.1
Grimm, T.2
Kogerman, L.3
Krause, D.4
Unden, A.B.5
Sandstedt, B.6
-
51
-
-
0033533714
-
Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1. Curr Biol
-
[PMID: 10531011]
-
Ding Q, Fukami S, Meng X, Nishizaki Y, Zhang X, Sasaki H, et al. Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1. Curr Biol. Oct 7 1999; 9 (19): 1119-1122. [PMID: 10531011]
-
(1999)
Oct 7
, vol.9
, Issue.19
, pp. 1119-1122
-
-
Ding, Q.1
Fukami, S.2
Meng, X.3
Nishizaki, Y.4
Zhang, X.5
Sasaki, H.6
-
52
-
-
59149087474
-
Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin-proteasome pathway. Oncogene
-
[PMID: 18997815]
-
Yue S, Chen Y and Cheng SY. Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin-proteasome pathway. Oncogene. Jan 29 2009; 28 (4): 492-499. [PMID: 18997815]
-
(2009)
Jan 29
, vol.28
, Issue.4
, pp. 492-499
-
-
Yue, S.1
Chen, Y.2
Cheng, S.Y.3
-
53
-
-
79958807613
-
A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model
-
[PMID: 21698280]
-
Strand MF, Wilson SR, Dembinski JL, Holsworth DD, Khvat A, Okun I, et al. A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model. PLoS One. 2011; 6 (6): e19904. [PMID: 21698280]
-
(2011)
PLoS One
, vol.6
, Issue.6
-
-
Strand, M.F.1
Wilson, S.R.2
Dembinski, J.L.3
Holsworth, D.D.4
Khvat, A.5
Okun, I.6
-
54
-
-
84857716118
-
Aberrations and therapeutics involving the developmental pathway Hedgehog in pancreatic cancer
-
[PMID: 22391312]
-
Kelleher FC and McDermott R. Aberrations and therapeutics involving the developmental pathway Hedgehog in pancreatic cancer. Vitam Horm. 2012; 88: 355-378. [PMID: 22391312]
-
(2012)
Vitam Horm
, vol.88
, pp. 355-378
-
-
Kelleher, F.C.1
McDermott, R.2
-
55
-
-
2942738996
-
The Hedgehog response network: Sensors, switches, and routers. Science
-
[PMID: 15205520]
-
Lum L and Beachy PA. The Hedgehog response network: sensors, switches, and routers. Science. Jun 18 2004; 304 (5678): 1755-1759. [PMID: 15205520]
-
(2004)
Jun 18
, vol.304
, Issue.5678
, pp. 1755-1759
-
-
Lum, L.1
Beachy, P.A.2
-
56
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles. Genes Dev
-
[PMID: 11731473]
-
Ingham PW and McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. Dec 1 2001; 15 (23): 3059-3087. [PMID: 11731473]
-
(2001)
Dec 1
, vol.15
, Issue.23
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
57
-
-
0023091971
-
Identification of an amplified, highly expressed gene in a human glioma. Science
-
[PMID: 3563490]
-
Kinzler KW, Bigner SH, Bigner DD, Trent JM, Law ML, O’Brien SJ, et al. Identification of an amplified, highly expressed gene in a human glioma. Science. Apr 3 1987; 236 (4797): 70-73. [PMID: 3563490]
-
(1987)
Apr 3
, vol.236
, Issue.4797
, pp. 70-73
-
-
Kinzler, K.W.1
Bigner, S.H.2
Bigner, D.D.3
Trent, J.M.4
Law, M.L.5
O’Brien, S.J.6
-
58
-
-
0025331133
-
Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila. Genes Dev
-
[PMID: 2166702]
-
Orenic TV, Slusarski DC, Kroll KL and Holmgren RA. Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila. Genes Dev. Jun 1990; 4 (6): 1053-1067. [PMID: 2166702]
-
(1990)
Jun
, vol.4
, Issue.6
, pp. 1053-1067
-
-
Orenic, T.V.1
Slusarski, D.C.2
Kroll, K.L.3
Holmgren, R.A.4
-
59
-
-
0033590144
-
Gli genes in development and cancer. Oncogene
-
[PMID: 10630638]
-
Matise MP and Joyner AL. Gli genes in development and cancer. Oncogene. Dec 20 1999; 18 (55): 7852-7859. [PMID: 10630638]
-
(1999)
Dec 20
, vol.18
, Issue.55
, pp. 7852-7859
-
-
Matise, M.P.1
Joyner, A.L.2
-
60
-
-
0033580269
-
Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature
-
[PMID: 10050855]
-
Chuang PT and McMahon AP. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature. Feb 18 1999; 397 (6720): 617-621. [PMID: 10050855]
-
(1999)
Feb 18
, vol.397
, Issue.6720
, pp. 617-621
-
-
Chuang, P.T.1
McMahon, A.P.2
-
61
-
-
0037212983
-
Hedgehog signaling in pancreas development. Mech Dev
-
[PMID: 12490295]
-
Hebrok M. Hedgehog signaling in pancreas development. Mech Dev. Jan 2003; 120 (1): 45-57. [PMID: 12490295]
-
(2003)
Jan
, vol.120
, Issue.1
, pp. 45-57
-
-
Hebrok, M.1
-
62
-
-
13144298531
-
Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors. BMC Cancer
-
[PMID: 15294024]
-
Olsen CL, Hsu PP, Glienke J, Rubanyi GM and Brooks AR. Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors. BMC Cancer. Aug 4 2004; 4: 43. [PMID: 15294024]
-
(2004)
Aug 4
, vol.4
, pp. 43
-
-
Olsen, C.L.1
Hsu, P.P.2
Glienke, J.3
Rubanyi, G.M.4
Brooks, A.R.5
-
63
-
-
25144461600
-
Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms. Cancer Biol Ther
-
[PMID: 15970691]
-
Martin ST, Sato N, Dhara S, Chang R, Hustinx SR, Abe T, et al. Aberrant methylation of the Human Hedgehog interacting protein (HHIP) gene in pancreatic neoplasms. Cancer Biol Ther. Jul 2005; 4 (7): 728-733. [PMID: 15970691]
-
(2005)
Jul
, vol.4
, Issue.7
, pp. 728-733
-
-
Martin, S.T.1
Sato, N.2
Dhara, S.3
Chang, R.4
Hustinx, S.R.5
Abe, T.6
-
64
-
-
17044384984
-
Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas. Mol Carcinog
-
[PMID: 15754313]
-
Kayed H, Kleeff J, Esposito I, Giese T, Keleg S, Giese N, et al. Localization of the human hedgehog-interacting protein (Hip) in the normal and diseased pancreas. Mol Carcinog. Apr 2005; 42 (4): 183-192. [PMID: 15754313]
-
(2005)
Apr
, vol.42
, Issue.4
, pp. 183-192
-
-
Kayed, H.1
Kleeff, J.2
Esposito, I.3
Giese, T.4
Keleg, S.5
Giese, N.6
-
65
-
-
64849094028
-
Hedgehog signalling: Emerging evidence for non-canonical pathways. Cell Signal
-
[PMID: 19399989]
-
Jenkins D. Hedgehog signalling: emerging evidence for non-canonical pathways. Cell Signal. Jul 2009; 21 (7): 1023-1034. [PMID: 19399989]
-
(2009)
Jul
, vol.21
, Issue.7
, pp. 1023-1034
-
-
Jenkins, D.1
-
66
-
-
0033772996
-
Factors controlling cyclin B expression. Plant Mol Biol
-
[PMID: 11089869]
-
Ito M. Factors controlling cyclin B expression. Plant Mol Biol. Aug 2000; 43 (5-6): 677-690. [PMID: 11089869]
-
(2000)
Aug
, vol.43
, Issue.5-6
, pp. 677-690
-
-
Ito, M.1
-
67
-
-
0035341310
-
Patched1 interacts with cyclin B1 to regulate cell cycle progression. EMBO J
-
[PMID: 11331587]
-
Barnes EA, Kong M, Ollendorff V and Donoghue DJ. Patched1 interacts with cyclin B1 to regulate cell cycle progression. EMBO J. May 1 2001; 20 (9): 2214-2223. [PMID: 11331587]
-
(2001)
May 1
, vol.20
, Issue.9
, pp. 2214-2223
-
-
Barnes, E.A.1
Kong, M.2
Ollendorff, V.3
Donoghue, D.J.4
-
68
-
-
70350534843
-
Hedgehog target genes: Mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. Curr Mol Med
-
[PMID: 19860666]
-
Katoh Y and Katoh M. Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. Curr Mol Med. Sep 2009; 9 (7): 873-886. [PMID: 19860666]
-
(2009)
Sep
, vol.9
, Issue.7
, pp. 873-886
-
-
Katoh, Y.1
Katoh, M.2
-
69
-
-
33947114865
-
Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling. Curr Biol
-
[PMID: 17331723]
-
Ulloa F, Itasaki N and Briscoe J. Inhibitory Gli3 activity negatively regulates Wnt/beta-catenin signaling. Curr Biol. Mar 20 2007; 17 (6): 545-550. [PMID: 17331723]
-
(2007)
Mar 20
, vol.17
, Issue.6
, pp. 545-550
-
-
Ulloa, F.1
Itasaki, N.2
Briscoe, J.3
-
70
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature
-
[PMID: 14520413]
-
Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. Oct 23 2003; 425 (6960): 851-856. [PMID: 14520413]
-
(2003)
Oct 23
, vol.425
, Issue.6960
, pp. 851-856
-
-
Thayer, S.P.1
di Magliano, M.P.2
Heiser, P.W.3
Nielsen, C.M.4
Roberts, D.J.5
Lauwers, G.Y.6
-
71
-
-
0242268525
-
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature
-
[PMID: 14520411]
-
Berman DM, Karhadkar SS, Maitra A, Montes De Oca R, Gerstenblith MR, Briggs K, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature. Oct 23 2003; 425 (6960): 846-851. [PMID: 14520411]
-
(2003)
Oct 23
, vol.425
, Issue.6960
, pp. 846-851
-
-
Berman, D.M.1
Karhadkar, S.S.2
Maitra, A.3
Montes De Oca, R.4
Gerstenblith, M.R.5
Briggs, K.6
-
72
-
-
33751209187
-
Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes Dev
-
[PMID: 17114586]
-
Pasca di Magliano M, Sekine S, Ermilov A, Ferris J, Dlugosz AA and Hebrok M. Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes Dev. Nov 15 2006; 20 (22): 3161-3173. [PMID: 17114586]
-
(2006)
Nov 15
, vol.20
, Issue.22
, pp. 3161-3173
-
-
Pasca di Magliano, M.1
Sekine, S.2
Ermilov, A.3
Ferris, J.4
Dlugosz, A.A.5
Hebrok, M.6
-
73
-
-
77950624255
-
Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors. Blood
-
[PMID: 20107231]
-
Merchant A, Joseph G, Wang Q, Brennan S and Matsui W. Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors. Blood. Mar 25 2010; 115 (12): 2391-2396. [PMID: 20107231]
-
(2010)
Mar 25
, vol.115
, Issue.12
, pp. 2391-2396
-
-
Merchant, A.1
Joseph, G.2
Wang, Q.3
Brennan, S.4
Matsui, W.5
-
74
-
-
34250612602
-
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development
-
[PMID: 17442700]
-
Vokes SA, Ji H, McCuine S, Tenzen T, Giles S, Zhong S, et al. Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development. May 2007; 134 (10): 1977-1989. [PMID: 17442700]
-
(2007)
May
, vol.134
, Issue.10
, pp. 1977-1989
-
-
Vokes, S.A.1
Ji, H.2
McCuine, S.3
Tenzen, T.4
Giles, S.5
Zhong, S.6
-
75
-
-
33750686955
-
The hedgehog signaling pathway in cancer. Clin Cancer Res
-
[PMID: 17062662]
-
Evangelista M, Tian H and de Sauvage FJ. The hedgehog signaling pathway in cancer. Clin Cancer Res. Oct 15 2006; 12 (20 Pt 1): 5924-5928. [PMID: 17062662]
-
(2006)
Oct 15
, vol.12
, Issue.20
, pp. 5924-5928
-
-
Evangelista, M.1
Tian, H.2
de Sauvage, F.J.3
-
76
-
-
34347253037
-
Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. J Biol Chem
-
[PMID: 17353198]
-
Ji Z, Mei FC, Xie J and Cheng X. Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. J Biol Chem. May 11 2007; 282 (19): 14048-14055. [PMID: 17353198]
-
(2007)
May 11
, vol.282
, Issue.19
, pp. 14048-14055
-
-
Ji, Z.1
Mei, F.C.2
Xie, J.3
Cheng, X.4
-
77
-
-
84876890682
-
Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation. J Biol Chem
-
[PMID: 23482563]
-
Mills LD, Zhang Y, Marler RJ, Herreros-Villanueva M, Zhang L, Almada LL, et al. Loss of the transcription factor GLI1 identifies a signaling network in the tumor microenvironment mediating KRAS oncogene-induced transformation. J Biol Chem. Apr 26 2013; 288 (17): 11786-11794. [PMID: 23482563]
-
(2013)
Apr 26
, vol.288
, Issue.17
, pp. 11786-11794
-
-
Mills, L.D.1
Zhang, Y.2
Marler, R.J.3
Herreros-Villanueva, M.4
Zhang, L.5
Almada, L.L.6
-
78
-
-
79551514021
-
TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling. Cancer Res
-
[PMID: 21189326]
-
Johnson RW, Nguyen MP, Padalecki SS, Grubbs BG, Merkel AR, Oyajobi BO, et al. TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling. Cancer Res. Feb 1 2011; 71 (3): 822-831. [PMID: 21189326]
-
(2011)
Feb 1
, vol.71
, Issue.3
, pp. 822-831
-
-
Johnson, R.W.1
Nguyen, M.P.2
Padalecki, S.S.3
Grubbs, B.G.4
Merkel, A.R.5
Oyajobi, B.O.6
-
79
-
-
67649446810
-
Integrative genomic analyses on GLI1: Positive regulation of GLI1 by Hedgehog-GLI, TGFbeta-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals. Int J Oncol
-
[PMID: 19513567]
-
Katoh Y and Katoh M. Integrative genomic analyses on GLI1: positive regulation of GLI1 by Hedgehog-GLI, TGFbeta-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signals. Int J Oncol. Jul 2009; 35 (1): 187-192. [PMID: 19513567]
-
(2009)
Jul
, vol.35
, Issue.1
, pp. 187-192
-
-
Katoh, Y.1
Katoh, M.2
-
80
-
-
84902123178
-
Inactivation of the transcription factor GLI1 accelerates pancreatic cancer progression. J Biol Chem
-
[PMID: 24737325]
-
Mills LD, Zhang L, Marler R, Svingen P, Fernandez-Barrena MG, Dave M, et al. Inactivation of the transcription factor GLI1 accelerates pancreatic cancer progression. J Biol Chem. Jun 6 2014; 289 (23): 16516-16525. [PMID: 24737325]
-
(2014)
Jun 6
, vol.289
, Issue.23
, pp. 16516-16525
-
-
Mills, L.D.1
Zhang, L.2
Marler, R.3
Svingen, P.4
Fernandez-Barrena, M.G.5
Dave, M.6
-
81
-
-
4344586961
-
Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res
-
[PMID: 15342389]
-
Kubo M, Nakamura M, Tasaki A, Yamanaka N, Nakashima H, Nomura M, et al. Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res. Sep 1 2004; 64 (17): 6071-6074. [PMID: 15342389]
-
(2004)
Sep 1
, vol.64
, Issue.17
, pp. 6071-6074
-
-
Kubo, M.1
Nakamura, M.2
Tasaki, A.3
Yamanaka, N.4
Nakashima, H.5
Nomura, M.6
-
82
-
-
79957613017
-
Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration. J Biol Chem
-
[PMID: 21474452]
-
Polizio AH, Chinchilla P, Chen X, Kim S, Manning DR and Riobo NA. Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration. J Biol Chem. Jun 3 2011; 286 (22): 19589-19596. [PMID: 21474452]
-
(2011)
Jun 3
, vol.286
, Issue.22
, pp. 19589-19596
-
-
Polizio, A.H.1
Chinchilla, P.2
Chen, X.3
Kim, S.4
Manning, D.R.5
Riobo, N.A.6
-
83
-
-
58149175893
-
Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model. Pancreas
-
[PMID: 18953259]
-
Guimaraes AR, Rakhlin E, Weissleder R and Thayer SP. Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model. Pancreas. Nov 2008; 37 (4): 440-444. [PMID: 18953259]
-
(2008)
Nov
, vol.37
, Issue.4
, pp. 440-444
-
-
Guimaraes, A.R.1
Rakhlin, E.2
Weissleder, R.3
Thayer, S.P.4
-
84
-
-
68149124175
-
Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer. Cancer Lett
-
[PMID: 19232458]
-
Xu FG, Ma QY and Wang Z. Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer. Cancer Lett. Oct 8 2009; 283 (2): 119-124. [PMID: 19232458]
-
(2009)
Oct 8
, vol.283
, Issue.2
, pp. 119-124
-
-
Xu, F.G.1
Ma, Q.Y.2
Wang, Z.3
-
85
-
-
34249867843
-
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A
-
[PMID: 17494766]
-
Lauth M, Bergstrom A, Shimokawa T and Toftgard R. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A. May 15 2007; 104 (20): 8455-8460. [PMID: 17494766]
-
(2007)
May 15
, vol.104
, Issue.20
, pp. 8455-8460
-
-
Lauth, M.1
Bergstrom, A.2
Shimokawa, T.3
Toftgard, R.4
-
86
-
-
85027912549
-
Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma
-
Jan 27, [PMID: 24469057]
-
Petrova E, Matevossian A and Resh MD. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene. Jan 27 2014. [PMID: 24469057]
-
(2014)
Oncogene
-
-
Petrova, E.1
Matevossian, A.2
Resh, M.D.3
-
87
-
-
84875424307
-
Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat Chem Biol
-
[PMID: 23416332]
-
Petrova E, Rios-Esteves J, Ouerfelli O, Glickman JF and Resh MD. Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat Chem Biol. Apr 2013; 9 (4): 247-249. [PMID: 23416332]
-
(2013)
Apr
, vol.9
, Issue.4
, pp. 247-249
-
-
Petrova, E.1
Rios-Esteves, J.2
Ouerfelli, O.3
Glickman, J.F.4
Resh, M.D.5
-
88
-
-
84905107941
-
Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding. Oncotarget
-
[PMID: 24962990]
-
Agyeman A, Jha BK, Mazumdar T and Houghton JA. Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding. Oncotarget. Jun 30 2014; 5 (12): 4492-4503. [PMID: 24962990]
-
(2014)
Jun 30
, vol.5
, Issue.12
, pp. 4492-4503
-
-
Agyeman, A.1
Jha, B.K.2
Mazumdar, T.3
Houghton, J.A.4
-
89
-
-
84872861115
-
GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett
-
[PMID: 23200667]
-
Fu J, Rodova M, Roy SK, Sharma J, Singh KP, Srivastava RK, et al. GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft. Cancer Lett. Mar 1 2013; 330 (1): 22-32. [PMID: 23200667]
-
(2013)
Mar 1
, vol.330
, Issue.1
, pp. 22-32
-
-
Fu, J.1
Rodova, M.2
Roy, S.K.3
Sharma, J.4
Singh, K.P.5
Srivastava, R.K.6
-
90
-
-
84883824170
-
Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo. Cancer Lett
-
[PMID: 23791879]
-
Guo J, Gao J, Li Z, Gong Y, Man X, Jin J, et al. Adenovirus vector-mediated Gli1 siRNA induces growth inhibition and apoptosis in human pancreatic cancer with Smo-dependent or Smo-independent Hh pathway activation in vitro and in vivo. Cancer Lett. Oct 10 2013; 339 (2): 185-194. [PMID: 23791879]
-
(2013)
Oct 10
, vol.339
, Issue.2
, pp. 185-194
-
-
Guo, J.1
Gao, J.2
Li, Z.3
Gong, Y.4
Man, X.5
Jin, J.6
-
91
-
-
32044436273
-
Dual degradation signals control Gli protein stability and tumor formation. Genes Dev
-
[PMID: 16421275]
-
Huntzicker EG, Estay IS, Zhen H, Lokteva LA, Jackson PK and Oro AE. Dual degradation signals control Gli protein stability and tumor formation. Genes Dev. Feb 1 2006; 20 (3): 276-281. [PMID: 16421275]
-
(2006)
Feb 1
, vol.20
, Issue.3
, pp. 276-281
-
-
Huntzicker, E.G.1
Estay, I.S.2
Zhen, H.3
Lokteva, L.A.4
Jackson, P.K.5
Oro, A.E.6
-
92
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science
-
[PMID: 19460966]
-
Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science. Jun 12 2009; 324 (5933): 1457-1461. [PMID: 19460966]
-
(2009)
Jun 12
, vol.324
, Issue.5933
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
Gopinathan, A.4
McIntyre, D.5
Honess, D.6
-
93
-
-
84903714441
-
Smarter drugs emerging in pancreatic cancer therapy
-
Mar 14, [PMID: 24631947]
-
Kleger A, Perkhofer L and Seufferlein T. Smarter drugs emerging in pancreatic cancer therapy. Ann Oncol. Mar 14 2014. [PMID: 24631947]
-
(2014)
Ann Oncol
-
-
Kleger, A.1
Perkhofer, L.2
Seufferlein, T.3
-
94
-
-
79954611501
-
Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. Clin Cancer Res
-
[PMID: 21300762]
-
LoRusso PM, Rudin CM, Reddy JC, Tibes R, Weiss GJ, Borad MJ, et al. Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. Clin Cancer Res. Apr 15 2011; 17 (8): 2502-2511. [PMID: 21300762]
-
(2011)
Apr 15
, vol.17
, Issue.8
, pp. 2502-2511
-
-
LoRusso, P.M.1
Rudin, C.M.2
Reddy, J.C.3
Tibes, R.4
Weiss, G.J.5
Borad, M.J.6
-
95
-
-
84886741654
-
Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med
-
[PMID: 24131140]
-
Von Hoff DD, Ervin T, Arena FP, Chiorean EG, Infante J, Moore M, et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. Oct 31 2013; 369 (18): 1691-1703. [PMID: 24131140]
-
(2013)
Oct 31
, vol.369
, Issue.18
, pp. 1691-1703
-
-
Von Hoff, D.D.1
Ervin, T.2
Arena, F.P.3
Chiorean, E.G.4
Infante, J.5
Moore, M.6
-
96
-
-
84903143748
-
A Phase II study of vismodegib, a hedgehog (Hh) pathway inhibitor, combined with gemcitabine and nab-paclitaxel (nab-P) in patients with untreated metastatic pancreatic ductal adenocarcinoma (PDA)
-
Jesus-Acosta D. A Phase II study of vismodegib, a hedgehog (Hh) pathway inhibitor, combined with gemcitabine and nab-paclitaxel (nab-P) in patients with untreated metastatic pancreatic ductal adenocarcinoma (PDA). J Clin Oncol. 2014; 32: 257.
-
(2014)
J Clin Oncol
, vol.32
, pp. 257
-
-
Jesus-Acosta, D.1
|