Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts

International Journal of Molecular Medicine

Volumn 19, Issue 3, 2007, Pages 445-451

  Lee, Sae Won ^a   Moskowitz, Michael A ^a   Sims, John R ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Angiogenesis; Angiopoietin; Hedgehog protein; Neurovascular unit

Indexed keywords

ANGIOPOIETIN 1; ANGIOPOIETIN 2; CYCLOPAMINE; GLI PROTEIN, MOUSE; KRUPPEL LIKE FACTOR; MESSENGER RNA; RECOMBINANT PROTEIN; SHH PROTEIN, MOUSE; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN A; VERATRUM ALKALOID;

ANIMAL; ARTICLE; CELL STRAIN 3T3; DOSE RESPONSE; DRUG EFFECT; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; NERVE CELL; STEM CELL;

ANGIOPOIETIN-1; ANGIOPOIETIN-2; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLASTS; GENE EXPRESSION REGULATION; HEDGEHOG PROTEINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; NEURONS; NIH 3T3 CELLS; RECOMBINANT PROTEINS; RNA, MESSENGER; STEM CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VERATRUM ALKALOIDS;

EID: 33947517650     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.19.3.445     Document Type: Article

References (42)

1. Cohen MM Jr: The hedgehog signaling network. Am J Med Genet A 123: 5-28, 2003.
2. Machold R, Hayashi S, Rutlin M, et al: Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron 39: 937-950, 2003.
3. Palma V, Lim DA, Dahmane N, et al: Sonic hedgehog controls stem cell behavior in the postnatal and adult brain. Development 132: 335-344, 2005.
4. Zhu G, Mehler MF, Zhao J, Yung SY and Kessler JA: Sonic hedgehog and BMP2 exert opposing actions on proliferation and differentiation of embryonic neural progenitor cells. Dev Biol 215: 118-129, 1999.
5. Charron F, Stein E, Jeong J, McMahon AP and Tessier-Lavigne M: The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell 113: 11-23, 2003.
6. Rowitch DH, St.-Jacques B, Lee SM, Flax JD, Snyder EY and McMahon AP: Sonic hedgehog regulates proliferation and inhibits differentiation of CNS precursor cells. J Neurosci 19: 8954-8965, 1999.
7. Chiang C, Litingtung Y, Lee E, et al: Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 383: 407-413, 1996.
8. Pola R, Ling LE, Aprahamian TR, et al: Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia. Circulation 108: 479-485, 2003.
9. Pola R, Ling LE, Silver M, et al: The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nat Med 7: 706-711, 2001.
10. Surace EM, Balaggan KS, Tessitore A, et al: Inhibition of ocular neovascularization by hedgehog blockade. Mol Ther 13: 573-579, 2006.
11. Kusano KF, Allendoerfer KL, Munger W, et al: Sonic hedgehog induces arteriogenesis in diabetic vasa nervorum and restores function in diabetic neuropathy. Arterioscler Thromb Vasc Biol 24: 2102-2107, 2004.
12. Carmeliet P: Angiogenesis in health and disease. Nat Med 9: 653-660, 2003.
13. Jain RK: Molecular regulation of vessel maturation. Nat Med 9: 685-693, 2003.
14. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ and Holash J: Vascular-specific growth factors and blood vessel formation. Nature 407: 242-248, 2000.
15. Holash J, Wiegand SJ and Yancopoulos GD: New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene 18: 5356-5362, 1999.
16. Lee SW, Kim WJ, Choi YK, et al: SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier. Nat Med 9: 900-906, 2003.
17. Joussen AM, Poulaki V, Tsujikawa A, et al: Suppression of diabetic retinopathy with angiopoietin-1. Am J Pathol 160: 1683-1693, 2002.
18. Thurston G, Rudge JS, Ioffe E, et al: Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med 6: 460-463, 2000.
19. Oshima Y, Oshima S, Nambu H, et al: Different effects of angiopoietin-2 in different vascular beds: new vessels are most sensitive. FASEB J 19: 963-965, 2005.
20. Muller PY, Janovjak H, Miserez AR and Dobbie Z: Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques 32: 1372-1379, 2002.
21. Ruiter D, Bogenrieder T, Elder D and Herlyn M: Melanomastroma interactions: structural and functional aspects. Lancet Oncol 3: 35-43, 2002.
22. Gnarra JR, Zhou S, Merrill MJ, et al: Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene. Proc Natl Acad Sci USA 93: 10589-10594, 1996.
23. Phelps ED, Updike DL, Bullen EC, Grammas P and Howard EW: Transcriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cells. Am J Physiol Cell Physiol 290: C352-C361, 2006.
24. Yu Y, Varughese J, Brown LF, Mulliken JB and Bischoff J: Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells. Am J Pathol 159: 2271-2280, 2001.
25. Pugh CW and Ratcliffe PJ: Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 9: 677-684, 2003.
26. Taipale J, Chen JK, Cooper MK, et al: Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406: 1005-1009, 2000.
27. Hirchenhain J, Huse I, Hess A, Bielfeld P, De Bruyne F and Krussel JS: Differential expression of angiopoietins 1 and 2 and their receptor Tie-2 in human endometrium. Mol Hum Reprod 9: 663-669, 2003.
28. Sandhu R, Teichert-Kuliszewska K, Nag S, et al: Reciprocal regulation of angiopoietin-1 and angiopoietin-2 following myocardial infarction in the rat. Cardiovasc Res 64: 115-124, 2004.
29. Carmeliet P and Tessier-Lavigne M: Common mechanisms of nerve and blood vessel wiring. Nature 436: 193-200, 2005.
30. Mukouyama YS, Shin D, Britsch S, Taniguchi M and Anderson DJ: Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin. Cell 109: 693-705, 2002.
31. Hangai M, He S, Hoffmann S, Lim JI, Ryan SJ and Hinton DR: Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells. J Neuroimmunol 171: 45-56, 2006.
32. Kim I, Kim JH, Ryu YS, Liu M and Koh GY: Tumor necrosis factor-alpha upregulates angiopoietin-2 in human umbilical vein endothelial cells. Biochem Biophys Res Commun 269: 361-365, 2000.
33. Krikun G, Schatz F, Finlay T, et al: Expression of angiopoietin-2 by human endometrial endothelial cells: regulation by hypoxia and inflammation. Biochem Biophys Res Commun 275: 159-163, 2000. (Pubitemid 30663645)
34. Zhang L, Yang N, Park JW, et al: Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer. Cancer Res 63: 3403-3412, 2003.
35. Hangai M, Murata T, Miyawaki N, et al: Angiopoietin-1 upregulation by vascular endothelial growth factor in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 42: 1617-1625, 2001.
36. Brindle NP, Saharinen P and Alitalo K: Signaling and functions of angiopoietin-1 in vascular protection. Circ Res 98: 1014-1023, 2006.
37. Hanahan D: Signaling vascular morphogenesis and maintenance. Science 277: 48-50, 1997.
38. Lawson ND, Vogel AM and Weinstein BM: Sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell 3: 127-136, 2002.
39. Thurston G, Suri C, Smith K, et al: Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science 286: 2511-2514, 1999.
40. Gale NW, Thurston G, Hackett SF, et al: Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by angiopoietin-1. Dev Cell 3: 411-423, 2002.
41. Kunz-Schughart LA, Schroeder JA, Wondrak M, et al: Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro. Am J Physiol Cell Physiol 290: C1385-C1398, 2006.
42. Velazquez OC, Snyder R, Liu ZJ, Fairman RM and Herlyn M: Fibroblast-dependent differentiation of human microvascular endothelial cells into capillary-like 3-dimensional networks. FASEB J 16: 1316-1318, 2002.