Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer

Cancer Letters

Volumn 283, Issue 2, 2009, Pages 119-124

  Xu, Fu Guo ^a   Ma, Qing Yong ^a   Wang, Zheng ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Anticancer treatment; Cyclopamine; Hedgehog signaling; Mechanism; Pancreatic cancer

Indexed keywords

5,6 DIHYDROXYARCYRIAFLAVIN A; 6 HYDROXYSTAUROSPORINONE; ADENOVIRUS VECTOR; ANTINEOPLASTIC AGENT; ARCYRIAFLAVIN C; CYCLOPAMINE; GEFITINIB; IPI 269609; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; N (3 METHOXYBENZYL) 3,3 DIMETHYL N [1 (3,4 METHYLENEDIOXYBENZYL) 2 (1 PIPERAZINYLCARBONYL) 4 PYRROLIDINYL]BUTYRAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHYSALIN B; PHYSALIN F; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN PATCHED; PROTEIN PATCHED 1 ANTIBODY; RAF PROTEIN; SANT 1; SANT 2; SANT 3; SANT 4; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; STAUROSPORINONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZERUMBONE; ZERUMBONE EPOXIDE; VERATRUM ALKALOID;

CANCER GENE THERAPY; CANCER INHIBITION; CANCER STEM CELL; CARCINOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; COMBINATION CHEMOTHERAPY; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG TARGETING; HUMAN; LOSS OF FUNCTION MUTATION; MONOTHERAPY; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHORT SURVEY; SIGNAL TRANSDUCTION; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; PANCREAS TUMOR; PHYSIOLOGY; REVIEW;

ERINACEIDAE;

ANIMALS; ANTINEOPLASTIC AGENTS; HEDGEHOG PROTEINS; HUMANS; PANCREATIC NEOPLASMS; SIGNAL TRANSDUCTION; VERATRUM ALKALOIDS;

EID: 68149124175     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.01.014     Document Type: Review

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