Patched1 functions as a gatekeeper by promoting cell cycle progression

Cancer Research

Volumn 66, Issue 4, 2006, Pages 2081-2088

  Adolphe, Christelle ^a   Hetherington, Rehan ^a   Ellis, Tammy ^a   Wainwright, Brandon ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CYCLIN B1; CYCLIN D1; NOTCH RECEPTOR; PROTEIN PATCHED 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASAL CELL CARCINOMA; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE G1 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CONTROLLED STUDY; FAMILIAL CANCER; GENE FUNCTION; GENE MUTATION; IN VIVO STUDY; KNOCKOUT GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN TRANSPORT; SKIN BIOPSY; SKIN CANCER; SKIN CARCINOGENESIS;

ANIMALS; BETA CATENIN; CARCINOMA, BASAL CELL; CELL CYCLE; CELL NUCLEUS; CELL TRANSFORMATION, NEOPLASTIC; CYCLIN B; CYCLIN D1; HAIR FOLLICLE; MICE; MICE, TRANSGENIC; RECEPTORS, CELL SURFACE; RECEPTORS, NOTCH; SKIN; SKIN NEOPLASMS;

EID: 33644509505     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-2146     Document Type: Article

References (54)

1. Pasca di Magliano M, Hebrok M. Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer 2003;3:903-11.
2. Gailani MR, Stahle-Backdahl M, Leffell DJ, et al. The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas. Nat Genet 1996;14:78-81.
3. Johnson RL, Rothman AL, Xie J, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 1996;272:1668-71.
4. Shen T, Park WS, Boni R, et al. Detection of loss of heterozygosity on chromosome 9q22.3 in microdissected sporadic basal cell carcinoma. Hum Pathol 1999;30:284-7.
5. Wicking C, Shanley S, Smyth I, et al. Most Germ-line Mutations in the nevoid basal cell carcinoma syndrome lead to premature truncation of the PATCHED protein, and no genotype-phenotype correlations are evident. Am J Hum Genet 1997;60:21-6.
6. Hahn H, Wicking C, Zaphiropoulos PG, et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 1996;85:841-51.
7. Goodrich LV, Milenkovic L, Higgins KM, Scott MP. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 1997;277:1109-13.
8. Mancuso M, Pazzaglia S, Tanori M, et al. Basal cell carcinoma and its development: insights from radiation-induced tumors in Ptch1-deficient mice. Cancer Res 2004;64:934-41.
9. +/- mice exposed to ultraviolet or ionizing radiation. Cancer Res 2004;64:4385-9.
10. Aszterbaum M, Beech J, Epstein EH, Jr. Ultraviolet radiation mutagenesis of hedgehog pathway genes in basal cell carcinomas. J Investig Dermatol Symp Proc 1999;4:41-5.
11. Ellis T, Smyth I, Riley E, et al. Patched 1 conditional null allele in mice. Genesis 2003;36:158-61.
12. Smyth I, Ellis T, Hetherington R, et al. Krt6a-Crc transgenic mice direct LoxP-mediated recombination to the companion cell layer of the hair follicle and following induction by retinoic acid to the interfollicular epidermis. J Invest Dermatol 2004;122:232-4.
13. Rothnagel JA, Seki T, Ogo M, et al. The mouse keratin 6 isoforms are differentially expressed in the hair follicle, footpad, tongue and activated epidermis. Differentiation 1999;65:119-30.
14. Mahony D, Karunaratne S, Cam G, Rothnagel JA. Analysis of mouse keratin 6a regulatory sequences in transgenic mice reveals constitutive, tissue-specific expression by a keratin 6a minigene. J Invest Dermatol 2000;115:795-804.
15. Adolphe C, Narang M, Ellis T, et al. An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis. Development 2004;131:5009-19.
16. Lobe CG, Koop KE, Kreppner W, et al. Z/AP, a double reporter for cre-mediated recombination. Dev Biol 1999;208:281-92.
17. Evans TM, Ferguson C, Wainwright BJ, Parton RG, Wicking C. Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway. Traffic 2003;4:869-84.
18. Oro AE, Higgins K. Hair cycle regulation of hedgehog signal reception. Dev Biol 2003;255:238-48.
19. Winter H, Langbein L, Praetzel S, et al. A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle. J Invest Dermatol 1998;111:955-62.
20. Rosenthal DS, Griffiths CE, Yuspa SH, Roop DR, Voorhees JJ. Acute or chronic topical retinoic acid treatment of human skin in vivo alters the expression of epidermal transglutaminase, loricrin, involucrin, filaggrin, and keratins 6 and 13 but not keratins 1, 10, and 14. J Invest Dermatol 1992;98:343-50.
21. Wodarz A, Nusse R. Mechanisms of Wnt signaling in development. Annu Rev Cell Dev Biol 1998;14:59-88.
22. El-Bahrawy M, El-Masry N, Alison M, Poulsom R, Fallowfield M. Expression of beta-catenin in basal cell carcinoma. Br J Dermatol 2003;148:964-70.
23. Yamazaki F, Aragane Y, Kawada A, Tezuka T. Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma. Br J Dermatol 2001:145:771-7.
24. Lo Muzio L, Pannone G, Staibano S, et al. WNT-1 expression in basal cell carcinoma of head and neck. An immunohistochemical and confocal study with regard to the intracellular distribution of beta-catenin. Anticancer Res 2002;22:565-76.
25. Saldanha G, Ghura V, Potter L, Fletcher A. Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation. Br J Dermatol 2004;151:157-64.
26. Methot N, Basler K. Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of cubitus interruptus. Development 2000;127:4001-10.
27. Ding Q, Fukami S, Meng X, et al. Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1. Curr Biol 1999;9:1119-22.
28. Murone M, Luoh SM, Stone D, et al. Gli regulation by the opposing activities of fused and suppressor of fused. Nat Cell Biol 2000;2:310-2.
29. Meng X, Poon R, Zhang X, et al. Suppressor of fused negatively regulates beta-catenin signaling. J Biol Chem 2001;276:40113-9.
30. Nicolas M, Wolfer A, Raj K, et al. Notch 1 functions as a tumor suppressor in mouse skin. Nat Genet 2003;33:416-21.
31. Lefort K, Dotto GP. Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression. Semin Cancer Biol 2004;14:374-86.
32. Kageyama R, Ohtsuka T, Hatakeyama J, Ohsawa R. Roles of bHLH genes in neural stem cell differentiation. Exp Cell Res 2005;306:343-8.
33. Duman-Scheel M, Weng L, Xin S, Du W. Hedgehog regulates cell growth and proliferation by inducing cyclin D and cyclin E. Nature 2002;417:299-304.
34. Barnes EA, Kong M, Ollendorff V, Donoghue DJ. Patched1 interacts with cyclin B1 to regulate cell cycle progression. EMBO J 2001;20:2214-23.
35. Fan H, Oro AE, Scott MP, Khavari PA. Induction of basal cell carcinoma features in transgenic human skin expressing sonic hedgehog. Nat Med 1997;3:788-92.
36. Oro AE, Higgins KM, Hu Z, et al. Basal cell carcinomas in mice overexpressing sonic hedgehog. Science 1997;276:817-21.
37. Nilsson M, Unden AB, Krause D, et al. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. Proc Natl Acad Sci U S A 2000;97:3438-43.
38. Grachtchouk M, Mo R, Yu S, et al. Basal cell carcinomas in mice overexpressing Gli2 in skin. Nat Genet 2000;24:216-7.
39. Xie J, Murone M, Luoh SM, et al. Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature 1998;391:90-2.
40. Aszterbaum M, Epstein J, Oro A, et al. Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nat Med 1999;5:1285-91.
41. Athar M, Li C, Tang X, et al. Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. Cancer Res 2004;64:7545-52.
42. Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature 2004;432:324-31.
43. Kinzler KW, Vogelstein B. Gatekeepers and caretakers. Nature 1997;386:762-3.
44. Vorechovsky I, Unden AB, Sandstedt B, Toftgard R, Stahle-Backdahl M. Trichoepitheliomas contain somatic mutations in the overexpressed PTCH gene: support for a gatekeeper mechanism in skin tumorigenesis. Cancer Res 1997;57:4677-81.
45. Dahmane N, Lee J, Robins P, Heller P, Ruiz i Altaba A. Activation of the transcription factor Gli1 and the sonic hedgehog signalling pathway in skin tumours. Nature 1997;389:876-81.
46. Teh MT, Wong ST, Neill GW, et al. FOXM1 is a downstream target of Gli1 in basal cell carcinomas. Cancer Res 2002;62:4773-80.
47. Ye H, Holterman AX, Yoo KW, Franks RR, Costa RH. Premature expression of the winged helix transcription factor HFH-11B in regenerating mouse liver accelerates hepatocyte entry into S phase. Mol Cell Biol 1999;19:8570-80.
48. Laoukili J, Kooistra MR, Bras A, et al. FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat Cell Biol 2005;7:126-36.
49. Fan H, Khavari PA. Sonic hedgehog opposes epithelial cell cycle arrest. J Cell Biol 1999;147:71-6.
50. Barnes EA, Heidtman KJ, Donoghue DJ. Constitutive activation of the shh-ptc1 pathway by a patched1 mutation identified in BCC. Oncogene 2005;24:902-15.
51. Mill P, Mo R, Hu MC, et al. Shh controls epithelial proliferation via independent pathways that converge on N-Myc. Dev Cell 2005;9:293-303.
52. Gat U, DasGupta R, Degenstein L, Fuchs E. De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell 1998;95:605-14.
53. Huelsken J, Vogel R, Erdmann B, Cotsarelis G, Birchmeier W. Beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 2001;105:533-45.
54. Romer JT, Kimura H, Magdaleno S, et al. Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell 2004;6:229-40.