Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer

Molecular Cancer Research

Volumn 10, Issue 9, 2012, Pages 1147-1157

  Hwang, Rosa F ^a   Moore, Todd T ^a   Hattersley, Maureen Mertens ^b   Scarpitti, Meghan ^a   Yang, Bin ^b   Devereaux, Erik ^b   Ramachandran, Vijaya ^a   Arumugam, Thiruvengadam ^a   Ji, Baoan ^a   Logsdon, Craig D ^a   Brown, Jeffrey L ^b   Godin, Robert ^b  

^a UNIVERSITY OF TEXAS   (United States)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AZD 8542; PROTEIN INHIBITOR; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLON CANCER; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PANCREAS CANCER; PANCREATIC STELLATE CELL; PARACRINE SIGNALING; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; STROMA;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; BENZAMIDES; CELL LINE, TUMOR; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEDGEHOG PROTEINS; HUMANS; IMIDAZOLES; LIVER NEOPLASMS; MALE; MICE; MICE, NUDE; NEOPLASM METASTASIS; PANCREATIC NEOPLASMS; PANCREATIC STELLATE CELLS; PARACRINE COMMUNICATION; PROSTATIC NEOPLASMS; RECEPTORS, G-PROTEIN-COUPLED; UP-REGULATION;

ERINACEIDAE;

EID: 84866490065     PISSN: 15417786     EISSN: 15573125     Source Type: Journal    
DOI: 10.1158/1541-7786.MCR-12-0022     Document Type: Article

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