TGF-β promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling

Cancer Research

Volumn 71, Issue 3, 2011, Pages 822-831

  Johnson, Rachelle W ^a,b,c   Nguyen, Mai P ^d   Padalecki, Susan S ^e,f   Grubbs, Barry G ^e   Merkel, Alyssa R ^a,c   Oyajobi, Babatunde O ^e,f   Matrisian, Lynn M ^b   Mundy, Gregory R ^a,b,c,d   Sterling, Julie A ^b,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d VANDERBILT UNIVERSITY   (United States)

^e Mays Cancer Center at UT Health San Antonio   (United States)

^f University of Texas Health Science Center at San Antonio   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPAMINE; MESSENGER RNA; PARATHYROID HORMONE RELATED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI2; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE DESTRUCTION; BONE METASTASIS; BREAST CANCER; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; HYPOTHESIS; IN VITRO STUDY; MOUSE; NONHUMAN; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR VOLUME;

ANIMALS; BONE NEOPLASMS; BREAST NEOPLASMS; FEMALE; HEDGEHOG PROTEINS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, NUDE; NUCLEAR PROTEINS; PARATHYROID HORMONE-RELATED PROTEIN; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; VERATRUM ALKALOIDS;

EID: 79551514021     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-2993     Document Type: Article

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